TFF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fibril organization (GO:0097435)9.67254816
2* digestion (GO:0007586)9.40602495
3glutathione derivative metabolic process (GO:1901685)9.06994036
4glutathione derivative biosynthetic process (GO:1901687)9.06994036
5O-glycan processing (GO:0016266)8.86761908
6sulfation (GO:0051923)8.38321612
7protein autoprocessing (GO:0016540)8.16808197
8* maintenance of gastrointestinal epithelium (GO:0030277)7.89075560
9hepatocyte apoptotic process (GO:0097284)7.53373276
10positive regulation of keratinocyte differentiation (GO:0045618)7.49476659
11regulation of proton transport (GO:0010155)7.47935780
12bundle of His cell to Purkinje myocyte communication (GO:0086069)7.11450556
13negative regulation of digestive system process (GO:0060457)6.86640839
14regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.82435442
15glandular epithelial cell differentiation (GO:0002067)6.72351337
16purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.70644357
173-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.70644357
18protein O-linked glycosylation (GO:0006493)6.33741777
19kidney morphogenesis (GO:0060993)6.21300842
20* epithelial structure maintenance (GO:0010669)5.96734321
21* digestive system process (GO:0022600)5.77262447
22ear development (GO:0043583)5.58884164
23production of molecular mediator of immune response (GO:0002440)5.56397200
24fucose catabolic process (GO:0019317)5.50994767
25L-fucose metabolic process (GO:0042354)5.50994767
26L-fucose catabolic process (GO:0042355)5.50994767
27regulation of phospholipase A2 activity (GO:0032429)5.50447039
28positive regulation of epidermal cell differentiation (GO:0045606)5.44692503
29positive regulation of Cdc42 GTPase activity (GO:0043089)5.34760784
30thyroid hormone metabolic process (GO:0042403)5.29863435
31regulation of cell proliferation involved in kidney development (GO:1901722)5.20900390
32intestinal absorption (GO:0050892)5.13777584
33sulfur amino acid catabolic process (GO:0000098)4.95362959
34thyroid hormone generation (GO:0006590)4.94903472
35COPI coating of Golgi vesicle (GO:0048205)4.91499011
36Golgi transport vesicle coating (GO:0048200)4.91499011
37glutathione metabolic process (GO:0006749)4.77655863
38vagina development (GO:0060068)4.71395878
39phosphatidylserine acyl-chain remodeling (GO:0036150)4.61854936
40phospholipid scrambling (GO:0017121)4.57543311
41regulation of keratinocyte differentiation (GO:0045616)4.57158821
42glucose 6-phosphate metabolic process (GO:0051156)4.45709750
43regulation of pH (GO:0006885)4.41135508
44xenobiotic metabolic process (GO:0006805)4.30311773
45maternal placenta development (GO:0001893)4.29060074
46embryonic camera-type eye morphogenesis (GO:0048596)4.28206400
47striated muscle atrophy (GO:0014891)4.27759033
48cell differentiation involved in embryonic placenta development (GO:0060706)4.27552682
49embryonic eye morphogenesis (GO:0048048)4.22950056
50ventricular cardiac muscle cell action potential (GO:0086005)4.22879900
51branching involved in mammary gland duct morphogenesis (GO:0060444)4.15750807
52regulation of fatty acid beta-oxidation (GO:0031998)4.14667726
53face development (GO:0060324)4.13209010
54negative regulation of cell size (GO:0045792)4.11871214
55peptidyl-arginine omega-N-methylation (GO:0035247)4.10028043
56norepinephrine metabolic process (GO:0042415)4.08249413
57receptor recycling (GO:0001881)4.03818450
58phosphatidylserine metabolic process (GO:0006658)4.02527860
59pH reduction (GO:0045851)4.01639852
60regulation of centriole replication (GO:0046599)4.00988252
61amyloid precursor protein catabolic process (GO:0042987)4.00785649
62leukotriene metabolic process (GO:0006691)4.00363461
63dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.96459826
64nitric oxide biosynthetic process (GO:0006809)3.94759470
65response to food (GO:0032094)3.94504982
66cardiac right ventricle morphogenesis (GO:0003215)3.91573133
67GDP-mannose metabolic process (GO:0019673)3.87978569
68proline biosynthetic process (GO:0006561)3.87859585
69diacylglycerol metabolic process (GO:0046339)3.83688438
70mesonephros development (GO:0001823)3.81055560
71lung secretory cell differentiation (GO:0061140)3.79393097
72phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.78588803
73skeletal muscle adaptation (GO:0043501)3.78563034
74regulation of water loss via skin (GO:0033561)3.75259496
75cyclooxygenase pathway (GO:0019371)3.74187840
76regulation of establishment or maintenance of cell polarity (GO:0032878)3.73904882
77cellular response to gonadotropin stimulus (GO:0071371)3.73762783
78negative regulation of organelle assembly (GO:1902116)3.73232550
79leukotriene biosynthetic process (GO:0019370)3.71364526
80cellular response to arsenic-containing substance (GO:0071243)3.64587887
81positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.61673175
82epithelial cell maturation (GO:0002070)3.61558559
83phosphatidylinositol acyl-chain remodeling (GO:0036149)3.61467514
84ethanol oxidation (GO:0006069)3.61362848
85post-embryonic morphogenesis (GO:0009886)3.61257893
86positive regulation of epidermis development (GO:0045684)3.61236128
87removal of superoxide radicals (GO:0019430)3.61179445
88cellular response to superoxide (GO:0071451)3.61179445
89cellular response to oxygen radical (GO:0071450)3.61179445
90muscle atrophy (GO:0014889)3.59231625
91regulation of mammary gland epithelial cell proliferation (GO:0033599)3.54158399
92acrosome reaction (GO:0007340)3.53795686
93adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.53206636
94phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.52939239
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.50698755
96regulation of interleukin-13 production (GO:0032656)3.43785917
97regulation of heart rate by cardiac conduction (GO:0086091)3.41870309
98cellular zinc ion homeostasis (GO:0006882)3.41534113
99intestinal epithelial cell development (GO:0060576)3.41371007
100neutrophil mediated immunity (GO:0002446)3.39151633
101viral mRNA export from host cell nucleus (GO:0046784)3.38592517
102peptidyl-arginine methylation (GO:0018216)3.38536253
103peptidyl-arginine N-methylation (GO:0035246)3.38536253
104positive regulation of translational initiation (GO:0045948)3.36766024
105negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.35987271
106protein retention in ER lumen (GO:0006621)3.35961952
107regulation of establishment of cell polarity (GO:2000114)3.35343439
108intracellular estrogen receptor signaling pathway (GO:0030520)3.34425823
109alditol phosphate metabolic process (GO:0052646)3.34416981
110acid secretion (GO:0046717)3.32849252
111female genitalia development (GO:0030540)3.32700508
112epithelial cell differentiation involved in prostate gland development (GO:0060742)3.31827072
113L-serine transport (GO:0015825)3.31358719
114response to water (GO:0009415)3.29656813
115atrioventricular valve morphogenesis (GO:0003181)3.28671495
116columnar/cuboidal epithelial cell differentiation (GO:0002065)3.27682320
117phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.26945038
118regulation of histone H3-K27 methylation (GO:0061085)3.26911723
119ribonucleoside bisphosphate metabolic process (GO:0033875)3.24814170
120nucleoside bisphosphate metabolic process (GO:0033865)3.24814170
121purine nucleoside bisphosphate metabolic process (GO:0034032)3.24814170
122negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.23937885
123uterus development (GO:0060065)3.23539516
124negative regulation of kidney development (GO:0090185)3.21228416
125positive regulation of fatty acid beta-oxidation (GO:0032000)3.19116008
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.18313730
127calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.18120333
128cytoskeletal anchoring at plasma membrane (GO:0007016)3.18028479
129cell proliferation involved in metanephros development (GO:0072203)3.17919878
130cellular response to estrogen stimulus (GO:0071391)3.17793559
131regulation of macrophage activation (GO:0043030)3.17560890
132response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.17182891
133response to superoxide (GO:0000303)3.16497394
134fucose metabolic process (GO:0006004)3.13870507
135fatty acid derivative transport (GO:1901571)3.13355201
136icosanoid transport (GO:0071715)3.13355201
137sodium ion export (GO:0071436)3.12333996
138regulation of glucose import in response to insulin stimulus (GO:2001273)3.11262391
139cobalamin metabolic process (GO:0009235)3.11163855
140negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.06613044
141outflow tract septum morphogenesis (GO:0003148)3.06456585
142growth hormone secretion (GO:0030252)3.05236887
143phosphate ion homeostasis (GO:0055062)3.05206903
144trivalent inorganic anion homeostasis (GO:0072506)3.05206903
145L-alpha-amino acid transmembrane transport (GO:1902475)3.03705653
146exocrine pancreas development (GO:0031017)3.03133088
147flavonoid metabolic process (GO:0009812)3.02448313
148cardiac conduction (GO:0061337)3.02413688
149histone arginine methylation (GO:0034969)3.02195076
150tight junction assembly (GO:0070830)3.01657570
151arachidonic acid secretion (GO:0050482)3.00890933
152icosanoid secretion (GO:0032309)3.00890933
153pentose-phosphate shunt (GO:0006098)3.00278509
154regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.00265501
155cell communication involved in cardiac conduction (GO:0086065)3.00110632
156biotin metabolic process (GO:0006768)2.97087679
157focal adhesion assembly (GO:0048041)2.96187906
158cell-substrate adherens junction assembly (GO:0007045)2.96187906
159trophectodermal cell differentiation (GO:0001829)2.95691188
160response to oxygen radical (GO:0000305)2.95045060
161monovalent inorganic cation homeostasis (GO:0055067)2.93605977
162regulation of cardioblast differentiation (GO:0051890)2.93530494
163regulation of epidermal cell differentiation (GO:0045604)2.92177452
164vitamin transport (GO:0051180)2.92074213
165embryonic skeletal joint morphogenesis (GO:0060272)2.90834444
166* response to iron ion (GO:0010039)2.90742674
167nucleotide-sugar biosynthetic process (GO:0009226)2.88584854
168activation of Rac GTPase activity (GO:0032863)2.87004992
169serine transport (GO:0032329)2.85766197
170mammary gland epithelial cell proliferation (GO:0033598)2.85179225
171embryonic foregut morphogenesis (GO:0048617)2.84412732
172regulation of apoptotic process involved in morphogenesis (GO:1902337)2.83607952
173regulation of transforming growth factor beta1 production (GO:0032908)2.83583954
174regulation of skeletal muscle contraction (GO:0014819)2.83508545
175mammary gland alveolus development (GO:0060749)2.81647411
176cellular glucuronidation (GO:0052695)2.80735293
177xenobiotic catabolic process (GO:0042178)2.80583520
178hormone catabolic process (GO:0042447)2.79851481
179adherens junction assembly (GO:0034333)2.78568225
180insulin-like growth factor receptor signaling pathway (GO:0048009)2.77982601
181response to gonadotropin (GO:0034698)2.77024208
182energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.76682376
183ATP hydrolysis coupled proton transport (GO:0015991)2.76682376
184amyloid precursor protein metabolic process (GO:0042982)2.76396650
185desmosome organization (GO:0002934)2.74044344
186TOR signaling (GO:0031929)2.72980073
187negative regulation of transcription by competitive promoter binding (GO:0010944)2.72595168
188ER overload response (GO:0006983)2.72017205
189negative regulation of cholesterol transport (GO:0032375)2.71440834
190negative regulation of adherens junction organization (GO:1903392)2.70527147
191negative regulation of focal adhesion assembly (GO:0051895)2.70527147
192negative regulation of cell junction assembly (GO:1901889)2.70527147
193glucose catabolic process (GO:0006007)2.67137608
194extracellular fibril organization (GO:0043206)11.2836356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX2_27498859_Chip-Seq_STOMACH_Mouse6.25817182
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.16630456
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45448810
4GATA4_25053715_ChIP-Seq_YYC3_Human3.16680757
5* ESR2_21235772_ChIP-Seq_MCF-7_Human2.86192626
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.82276957
7TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.71781381
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68130923
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62211389
10PPAR_26484153_Chip-Seq_NCI-H1993_Human2.55745332
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.51772555
12ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.49798970
13* SOX2_20726797_ChIP-Seq_SW620_Human2.47946219
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46282193
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.44586668
16GATA6_25053715_ChIP-Seq_YYC3_Human2.36320177
17IGF1R_20145208_ChIP-Seq_DFB_Human2.34085770
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30727981
19* ESR1_21235772_ChIP-Seq_MCF-7_Human2.23286827
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.13598610
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.06141710
22* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.05224837
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.01236125
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.95647062
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.95540385
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95034497
27STAT1_20625510_ChIP-Seq_HELA_Human1.94880220
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91075740
29KLF5_25053715_ChIP-Seq_YYC3_Human1.88165396
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86540282
31VDR_22108803_ChIP-Seq_LS180_Human1.82778913
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.82442020
33* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.82088286
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.74794839
35EGR1_19032775_ChIP-ChIP_M12_Human1.74185396
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.73415545
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73130948
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.72976549
39AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.69030369
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68995777
41GATA3_24758297_ChIP-Seq_MCF-7_Human1.68227447
42LXR_22292898_ChIP-Seq_THP-1_Human1.68095606
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.65096579
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.64705265
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.62751784
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60464969
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57889820
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57195126
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55030711
50KDM5A_27292631_Chip-Seq_BREAST_Human1.53729770
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.53256394
52MYC_22102868_ChIP-Seq_BL_Human1.50605378
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.49766699
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46375001
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.46167134
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45720158
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45720158
58VDR_21846776_ChIP-Seq_THP-1_Human1.45501297
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45341588
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45016399
61JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44327086
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44092951
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43833529
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42852703
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38216327
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37244090
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36844898
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36755454
69TCF7_22412390_ChIP-Seq_EML_Mouse1.36357603
70* AHR_22903824_ChIP-Seq_MCF-7_Human1.35520421
71FOXA2_19822575_ChIP-Seq_HepG2_Human1.34652825
72ZNF263_19887448_ChIP-Seq_K562_Human1.34265372
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34156778
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34040266
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31793336
76ELF5_23300383_ChIP-Seq_T47D_Human1.31747996
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31586853
78E2F7_22180533_ChIP-Seq_HELA_Human1.30964875
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.28789223
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.28247537
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27698373
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27553923
83ZNF274_21170338_ChIP-Seq_K562_Hela1.27387415
84XRN2_22483619_ChIP-Seq_HELA_Human1.26339041
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.26309755
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25552046
87RXR_22108803_ChIP-Seq_LS180_Human1.23724860
88BCAT_22108803_ChIP-Seq_LS180_Human1.23231142
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23073805
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21949514
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21684643
92* RACK7_27058665_Chip-Seq_MCF-7_Human1.21477304
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21125688
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21018476
95* RUNX1_27514584_Chip-Seq_MCF-7_Human1.20683238
96ER_23166858_ChIP-Seq_MCF-7_Human1.20491326
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19379302
98KDM2B_26808549_Chip-Seq_K562_Human1.18129174
99MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18004367
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17909933
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17443988
102DCP1A_22483619_ChIP-Seq_HELA_Human1.14080794
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13687410
104JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12910484
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11024193
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09520388
107P68_20966046_ChIP-Seq_HELA_Human1.09346637
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08939654
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08788055
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08311600
111SMC4_20622854_ChIP-Seq_HELA_Human1.08256766
112DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07572579
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06692433
114E2F1_21310950_ChIP-Seq_MCF-7_Human1.05748991
115CLOCK_20551151_ChIP-Seq_293T_Human1.03778168
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02697317
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02455049
118* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01922268
119KDM2B_26808549_Chip-Seq_DND41_Human1.01148391
120RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00319583
121SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00051786
122CJUN_26792858_Chip-Seq_BT549_Human0.99164978
123CTCF_26484167_Chip-Seq_Bcells_Mouse0.99112813
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98657246
125ATF3_27146783_Chip-Seq_COLON_Human0.97770328
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97180794
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96151526
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95399944
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95068687
130CHD1_26751641_Chip-Seq_LNCaP_Human0.94510499
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94457992
132SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93625201
133CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93577921
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93572618
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.93495692
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.93066615
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92753167
138* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92363282
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91283176
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91283176
141GABP_19822575_ChIP-Seq_HepG2_Human0.91173582
142SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90851284
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90759970
144SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90485990
145KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90351450
146KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90351450
147KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90351450
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.90061848
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.90061848
150FOXP1_21924763_ChIP-Seq_HESCs_Human0.89026007
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89013480
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88569388
153TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88262426
154* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88159079
155P53_21459846_ChIP-Seq_SAOS-2_Human0.88079626
156FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86927815
157EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86443918
158* ARNT_22903824_ChIP-Seq_MCF-7_Human0.82315627
159GATA1_19941826_ChIP-Seq_K562_Human0.81750664
160NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81449218
161NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80276405
162EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79959799
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.79596049
164CREB1_26743006_Chip-Seq_LNCaP_Human0.78787655
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77878096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation6.12655090
2* MP0001664_abnormal_digestion4.20739010
3MP0003806_abnormal_nucleotide_metabolis3.56319178
4* MP0000470_abnormal_stomach_morphology3.25622191
5MP0003123_paternal_imprinting3.03108253
6MP0005076_abnormal_cell_differentiation2.90417993
7MP0000383_abnormal_hair_follicle2.59660466
8MP0004381_abnormal_hair_follicle2.57836757
9MP0001663_abnormal_digestive_system2.17861075
10MP0004782_abnormal_surfactant_physiolog2.11196454
11MP0000538_abnormal_urinary_bladder2.02450412
12MP0008004_abnormal_stomach_pH17.8578664
13MP0002249_abnormal_larynx_morphology1.98343468
14MP0000427_abnormal_hair_cycle1.97773355
15MP0005381_digestive/alimentary_phenotyp1.88759244
16MP0010234_abnormal_vibrissa_follicle1.86851197
17MP0004233_abnormal_muscle_weight1.86730801
18MP0000377_abnormal_hair_follicle1.85680067
19MP0000627_abnormal_mammary_gland1.81603368
20MP0003941_abnormal_skin_development1.78709099
21MP0001666_abnormal_nutrient_absorption1.76249525
22MP0005451_abnormal_body_composition1.73189187
23MP0005165_increased_susceptibility_to1.72715023
24MP0000579_abnormal_nail_morphology1.66865830
25MP0002751_abnormal_autonomic_nervous1.60100245
26MP0002089_abnormal_postnatal_growth/wei1.58285982
27MP0001727_abnormal_embryo_implantation1.57145512
28MP0003942_abnormal_urinary_system1.55520215
29MP0009672_abnormal_birth_weight1.55350196
30MP0005083_abnormal_biliary_tract1.46274155
31MP0000534_abnormal_ureter_morphology1.45343338
32MP0009840_abnormal_foam_cell1.44424373
33MP0005248_abnormal_Harderian_gland1.43067932
34MP0005075_abnormal_melanosome_morpholog1.36338761
35MP0003693_abnormal_embryo_hatching1.31965905
36MP0005058_abnormal_lysosome_morphology1.31021571
37MP0003936_abnormal_reproductive_system1.29645735
38MP0001881_abnormal_mammary_gland1.24826973
39MP0000750_abnormal_muscle_regeneration1.24512107
40MP0000678_abnormal_parathyroid_gland1.23641715
41MP0004264_abnormal_extraembryonic_tissu1.23237128
42MP0005423_abnormal_somatic_nervous1.22928189
43MP0008260_abnormal_autophagy1.22139821
44MP0005085_abnormal_gallbladder_physiolo1.17002581
45MP0005409_darkened_coat_color1.12519527
46MP0003186_abnormal_redox_activity1.11136762
47MP0003283_abnormal_digestive_organ1.09809684
48MP0006054_spinal_hemorrhage1.07250936
49MP0001919_abnormal_reproductive_system1.06371286
50MP0002909_abnormal_adrenal_gland0.96429523
51MP0003705_abnormal_hypodermis_morpholog0.96078413
52* MP0000477_abnormal_intestine_morphology0.95797002
53MP0005365_abnormal_bile_salt0.93148926
54MP0003183_abnormal_peptide_metabolism0.91169176
55MP0010030_abnormal_orbit_morphology0.90285141
56MP0002160_abnormal_reproductive_system0.89130360
57MP0005646_abnormal_pituitary_gland0.88892903
58MP0008995_early_reproductive_senescence0.87876717
59MP0003787_abnormal_imprinting0.87809081
60MP0003115_abnormal_respiratory_system0.86937591
61MP0000371_diluted_coat_color0.86148476
62MP0008875_abnormal_xenobiotic_pharmacok0.85109166
63MP0004957_abnormal_blastocyst_morpholog0.83941643
64MP0000462_abnormal_digestive_system0.83169301
65MP0000490_abnormal_crypts_of0.76102558
66MP0009384_cardiac_valve_regurgitation0.74866479
67MP0002127_abnormal_cardiovascular_syste0.74439187
68MP0001186_pigmentation_phenotype0.73917485
69MP0003868_abnormal_feces_composition0.73189874
70MP0002184_abnormal_innervation0.72905301
71MP0010329_abnormal_lipoprotein_level0.71676481
72MP0009703_decreased_birth_body0.71278351
73MP0010094_abnormal_chromosome_stability0.70549695
74MP0005266_abnormal_metabolism0.70298349
75MP0000537_abnormal_urethra_morphology0.69432564
76MP0005636_abnormal_mineral_homeostasis0.68660827
77MP0000613_abnormal_salivary_gland0.68467705
78MP0002108_abnormal_muscle_morphology0.67665599
79MP0008872_abnormal_physiological_respon0.67336388
80MP0002139_abnormal_hepatobiliary_system0.65839494
81MP0002166_altered_tumor_susceptibility0.64542546
82MP0002075_abnormal_coat/hair_pigmentati0.64132110
83MP0002080_prenatal_lethality0.62956813
84MP0001697_abnormal_embryo_size0.62344739
85MP0004484_altered_response_of0.62004242
86MP0005375_adipose_tissue_phenotype0.61580158
87MP0002088_abnormal_embryonic_growth/wei0.61261886
88MP0000681_abnormal_thyroid_gland0.60482575
89MP0004185_abnormal_adipocyte_glucose0.59463791
90MP0001340_abnormal_eyelid_morphology0.58821472
91MP0008932_abnormal_embryonic_tissue0.58409085
92MP0001672_abnormal_embryogenesis/_devel0.57975919
93MP0010155_abnormal_intestine_physiology0.57431781
94MP0004858_abnormal_nervous_system0.56696666
95MP0002234_abnormal_pharynx_morphology0.56537214
96MP0002796_impaired_skin_barrier0.54323870
97MP0000467_abnormal_esophagus_morphology0.54033764
98MP0003075_altered_response_to0.53552265
99MP0002877_abnormal_melanocyte_morpholog0.52149037
100MP0001243_abnormal_dermal_layer0.49724469
101MP0002118_abnormal_lipid_homeostasis0.45745546
102MP0004947_skin_inflammation0.44262274
103MP0003191_abnormal_cellular_cholesterol0.42239378
104MP0002009_preneoplasia0.41543441
105MP0003566_abnormal_cell_adhesion0.41175428
106MP0003953_abnormal_hormone_level0.41170059
107MP0002078_abnormal_glucose_homeostasis0.38229711
108MP0003866_abnormal_defecation0.37397529
109MP0005166_decreased_susceptibility_to0.36588599
110MP0008873_increased_physiological_sensi0.36364686
111MP0005584_abnormal_enzyme/coenzyme_acti0.35975098
112MP0002693_abnormal_pancreas_physiology0.35740835
113MP0003252_abnormal_bile_duct0.35663508
114MP0009780_abnormal_chondrocyte_physiolo0.34262110
115MP0001216_abnormal_epidermal_layer0.33596868
116MP0010678_abnormal_skin_adnexa0.32843754
117MP0005360_urolithiasis0.32742927
118MP0003724_increased_susceptibility_to0.32354090
119MP0002060_abnormal_skin_morphology0.32165557
120MP0010352_gastrointestinal_tract_polyps0.32032422
121MP0000609_abnormal_liver_physiology0.31654602
122MP0001845_abnormal_inflammatory_respons0.30764965
123MP0005319_abnormal_enzyme/_coenzyme0.29603612
124MP0002970_abnormal_white_adipose0.28677892
125MP0005408_hypopigmentation0.27836932
126MP0001849_ear_inflammation0.27394578
127MP0003638_abnormal_response/metabolism_0.26981289
128MP0009642_abnormal_blood_homeostasis0.26842807
129MP0003453_abnormal_keratinocyte_physiol0.26753435
130MP0003329_amyloid_beta_deposits0.26743334
131MP0000367_abnormal_coat/_hair0.26303102
132MP0000598_abnormal_liver_morphology0.26081820
133MP0005376_homeostasis/metabolism_phenot0.25346204
134MP0004130_abnormal_muscle_cell0.24761652
135MP0004043_abnormal_pH_regulation0.24575523
136MP0003119_abnormal_digestive_system0.23988569
137MP0005332_abnormal_amino_acid0.23367063
138MP0005501_abnormal_skin_physiology0.21895837
139MP0004019_abnormal_vitamin_homeostasis0.21136934
140MP0000013_abnormal_adipose_tissue0.20781640
141MP0003656_abnormal_erythrocyte_physiolo0.20651370
142MP0005275_abnormal_skin_tensile0.18332806
143MP0005464_abnormal_platelet_physiology0.17987674
144* MP0002019_abnormal_tumor_incidence0.17873182
145MP0009643_abnormal_urine_homeostasis0.17157942
146MP0008961_abnormal_basal_metabolism0.17069136
147MP0010771_integument_phenotype0.16820000
148MP0005310_abnormal_salivary_gland0.16618653
149MP0002837_dystrophic_cardiac_calcinosis0.16239091
150MP0005452_abnormal_adipose_tissue0.15829962
151MP0005367_renal/urinary_system_phenotyp0.15120018
152MP0000516_abnormal_urinary_system0.15120018
153MP0004859_abnormal_synaptic_plasticity0.15051359
154MP0000465_gastrointestinal_hemorrhage0.14866579
155MP0002098_abnormal_vibrissa_morphology0.14715527
156MP0009053_abnormal_anal_canal0.14607551
157MP0009931_abnormal_skin_appearance0.14598773
158MP0003690_abnormal_glial_cell0.14082824
159MP0000604_amyloidosis0.13810432
160MP0005666_abnormal_adipose_tissue0.13594508

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)9.65141881
2Abnormality of cells of the erythroid lineage (HP:0012130)9.06054583
3J-shaped sella turcica (HP:0002680)7.24480586
4Asymmetry of the thorax (HP:0001555)6.38936867
5Microglossia (HP:0000171)5.19230590
6Megaloblastic anemia (HP:0001889)5.15340522
7Septate vagina (HP:0001153)5.04767591
8Abnormality of the vitamin B12 metabolism (HP:0004341)4.94181743
9Concave nail (HP:0001598)4.76420119
10Abnormality of vitamin B metabolism (HP:0004340)4.66875364
11Palpitations (HP:0001962)4.54102872
12Goiter (HP:0000853)4.39885340
13Absent frontal sinuses (HP:0002688)4.38142280
14Gout (HP:0001997)4.37485158
15Distal lower limb muscle weakness (HP:0009053)4.21022566
16Abnormality of vitamin metabolism (HP:0100508)4.20971333
17Deformed sella turcica (HP:0002681)4.15935276
18Syncope (HP:0001279)4.15271388
19Woolly hair (HP:0002224)4.01982318
20Breast carcinoma (HP:0003002)3.88338588
21Intrahepatic cholestasis (HP:0001406)3.82685302
22Abnormality of purine metabolism (HP:0004352)3.62348907
23Abnormality of the umbilical cord (HP:0010881)3.54579151
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48092470
25Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.47679921
26Ventricular fibrillation (HP:0001663)3.37569782
27Abnormality of the frontal sinuses (HP:0002687)3.20744862
28Frequent falls (HP:0002359)3.18825362
29Germ cell neoplasia (HP:0100728)3.14883017
30Thin bony cortex (HP:0002753)3.08210436
31Hyperparathyroidism (HP:0000843)3.07948146
32Enlarged penis (HP:0000040)3.06606621
33Arterial tortuosity (HP:0005116)3.02033133
34Amelogenesis imperfecta (HP:0000705)3.01552307
35Back pain (HP:0003418)3.01458342
36Spinal cord compression (HP:0002176)2.98565169
37Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.98477129
38Sparse lateral eyebrow (HP:0005338)2.94634871
39Chromsome breakage (HP:0040012)2.94070436
40Ventricular arrhythmia (HP:0004308)2.92140846
41Long toe (HP:0010511)2.90429870
42Glomerulosclerosis (HP:0000096)2.83008708
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.82740000
44Abnormality of the sella turcica (HP:0002679)2.82692289
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.77527125
46Macroorchidism (HP:0000053)2.76015731
47Increased purine levels (HP:0004368)2.75196456
48Hyperuricemia (HP:0002149)2.75196456
49Testicular atrophy (HP:0000029)2.72932306
50Deep venous thrombosis (HP:0002625)2.66005724
51Vascular tortuosity (HP:0004948)2.65570473
52Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.65361535
53Syringomyelia (HP:0003396)2.59644672
54Spinal cord lesions (HP:0100561)2.59644672
55Ventricular tachycardia (HP:0004756)2.57820280
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57412081
57Reticulocytosis (HP:0001923)2.56500237
58Flat acetabular roof (HP:0003180)2.55830853
59Hemorrhage of the eye (HP:0011885)2.52097216
60Conjugated hyperbilirubinemia (HP:0002908)2.49400617
61Hyporeflexia of lower limbs (HP:0002600)2.48836500
62Aortic dissection (HP:0002647)2.48814886
63Hypercortisolism (HP:0001578)2.43102195
64Agitation (HP:0000713)2.41175700
65Axonal loss (HP:0003447)2.40927153
66Hemiplegia (HP:0002301)2.40443971
67Increased cerebral lipofuscin (HP:0011813)2.36282583
68Depressed nasal tip (HP:0000437)2.33671347
69Vascular calcification (HP:0004934)2.32110888
70Micronodular cirrhosis (HP:0001413)2.31381561
71Infantile muscular hypotonia (HP:0008947)2.30146122
72Abnormalities of placenta or umbilical cord (HP:0001194)2.27267489
73Abnormal cartilage morphology (HP:0002763)2.27224242
74Bulbar palsy (HP:0001283)2.27078041
75Ketoacidosis (HP:0001993)2.26171682
76Deep philtrum (HP:0002002)2.26168164
77Abnormality of the gastric mucosa (HP:0004295)2.23825021
78Abnormality of the fetal cardiovascular system (HP:0010948)2.23713000
79Abnormal umbilical cord blood vessels (HP:0011403)2.23713000
80Single umbilical artery (HP:0001195)2.23713000
81Sensorimotor neuropathy (HP:0007141)2.18112878
82Pterygium (HP:0001059)2.16801961
83Abnormality of nail color (HP:0100643)2.16124363
84Cardiovascular calcification (HP:0011915)2.15727791
85Lymphangioma (HP:0100764)2.15664995
86Ulnar claw (HP:0001178)2.15448376
87Abnormality of nucleobase metabolism (HP:0010932)2.14805545
88Ketosis (HP:0001946)2.12818594
89Curly hair (HP:0002212)2.11809040
90Increased variability in muscle fiber diameter (HP:0003557)2.10165568
91Short nail (HP:0001799)2.09444089
92Focal segmental glomerulosclerosis (HP:0000097)2.09042315
93Atrophic scars (HP:0001075)2.09036557
94Sudden cardiac death (HP:0001645)2.07291647
95Abnormality of reticulocytes (HP:0004312)2.05868402
96Exostoses (HP:0100777)2.05564261
97Congenital glaucoma (HP:0001087)2.05226650
98Esophageal varix (HP:0002040)2.05065273
99Hyperacusis (HP:0010780)2.04237156
100Hyperammonemia (HP:0001987)2.03342966
101Cupped ribs (HP:0000887)2.01065598
102Abnormal number of erythroid precursors (HP:0012131)10.1775120
103Xanthomatosis (HP:0000991)1.99605149
104Hypoalphalipoproteinemia (HP:0003233)1.99307423
105Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.99276454
106Generalized amyotrophy (HP:0003700)1.99150447
107Renal salt wasting (HP:0000127)1.98787743
108Easy fatigability (HP:0003388)1.98292904
109Hypoparathyroidism (HP:0000829)1.98202094
110Ankyloglossia (HP:0010296)1.97585253
111Buphthalmos (HP:0000557)1.95258464
112Congenital ichthyosiform erythroderma (HP:0007431)1.93050090
113Broad face (HP:0000283)1.92403727
114Bicornuate uterus (HP:0000813)1.92383243
115Hypoglycemic coma (HP:0001325)1.89784253
116Generalized hypopigmentation of hair (HP:0011358)1.88647425
117Conjunctival hamartoma (HP:0100780)1.88603576
118Abnormality of skeletal muscle fiber size (HP:0012084)1.88578970
119Pustule (HP:0200039)1.88077752
120Cervical subluxation (HP:0003308)1.87987163
121Abnormal gallbladder physiology (HP:0012438)1.87718467
122Cholecystitis (HP:0001082)1.87718467
123Lethargy (HP:0001254)1.84665712
124Tubulointerstitial nephritis (HP:0001970)1.83792559
125Abnormal urine phosphate concentration (HP:0012599)1.81856206
126Abnormality of calcium-phosphate metabolism (HP:0100530)1.81743031
127Abnormality of sulfur amino acid metabolism (HP:0004339)1.81561740
128Termporal pattern (HP:0011008)1.81248411
129Insidious onset (HP:0003587)1.81248411
130Malnutrition (HP:0004395)1.80553396
131Tubulointerstitial fibrosis (HP:0005576)1.79520161
132Flat capital femoral epiphysis (HP:0003370)1.79386989
133Abnormality of fatty-acid metabolism (HP:0004359)1.79201256
134Abdominal distention (HP:0003270)1.78548292
135Hypokinesia (HP:0002375)1.77095718
136Restlessness (HP:0000711)1.76978226
137Progressive muscle weakness (HP:0003323)1.76580538
138Hypopigmentation of the fundus (HP:0007894)1.76314564
139High pitched voice (HP:0001620)1.75856685
140Abnormality of the preputium (HP:0100587)1.75813060
141Abnormality of the Achilles tendon (HP:0005109)1.75740247
142Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75504385
143Pili torti (HP:0003777)1.75349869
144Paresthesia (HP:0003401)1.74249303
145Prolonged neonatal jaundice (HP:0006579)1.74104661
146Hyperglycemia (HP:0003074)1.73113089
147Meningioma (HP:0002858)1.72614083
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72266815
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71742220
150Fasciculations (HP:0002380)1.71496418
151Growth hormone excess (HP:0000845)1.71200188
152Thyroid carcinoma (HP:0002890)1.70793835
153Milia (HP:0001056)1.70472472
154Abnormality of the thoracic spine (HP:0100711)1.70150231
155Cone-rod dystrophy (HP:0000548)1.70061723
156Achilles tendon contracture (HP:0001771)1.69533172
157Short thumb (HP:0009778)1.67659708
158Spastic tetraparesis (HP:0001285)1.66252727
159Turricephaly (HP:0000262)1.65626578
160Abnormal tarsal ossification (HP:0008369)1.65264675
161Macrocytic anemia (HP:0001972)1.64354913
162Leiomyosarcoma (HP:0100243)1.64130898
163Uterine leiomyosarcoma (HP:0002891)1.64130898
164Fragile nails (HP:0001808)1.63590075
165Seborrheic dermatitis (HP:0001051)1.63145770
166Hyperphosphatemia (HP:0002905)1.60740240
167Cutaneous melanoma (HP:0012056)1.60615289
168Diaphragmatic weakness (HP:0009113)1.59848079
169Neoplasm of the thyroid gland (HP:0100031)1.59553400
170Periodontitis (HP:0000704)1.59368266
171Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.59239187
172Ectopia lentis (HP:0001083)1.58892558
173Abnormality of the distal phalanges of the toes (HP:0010182)1.58571741
174Patellar dislocation (HP:0002999)1.58337204
175Fragile skin (HP:0001030)1.55897616
176Polygenic inheritance (HP:0010982)1.54959218
177Aneurysm (HP:0002617)1.54924672
178Testicular neoplasm (HP:0010788)1.54836355
179Mildly elevated creatine phosphokinase (HP:0008180)1.54786444
180Macroglossia (HP:0000158)1.54632224
181Abnormality of oral frenula (HP:0000190)1.53979829
182Death in childhood (HP:0003819)1.52422395
183Onycholysis (HP:0001806)1.52202093
184Plantar hyperkeratosis (HP:0007556)1.52159404
185Spastic diplegia (HP:0001264)1.49134496
186Bundle branch block (HP:0011710)1.48715261
187Spinal rigidity (HP:0003306)1.48655302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK5.70416757
2MST44.53770622
3SIK14.08636198
4MST1R4.02743588
5SCYL23.85398557
6MAPKAPK33.17143412
7EPHA23.06508642
8SMG12.67366093
9IRAK32.11459550
10TRIB32.04265326
11ERBB413.5069450
12NEK61.95923153
13PKN21.89932576
14VRK21.67900168
15LRRK21.63225037
16MET1.61435808
17MAP3K121.58408898
18MAP3K91.56635122
19KSR21.55552798
20RIPK41.51091363
21ILK1.35949900
22PIK3CG1.35244015
23MAP3K21.30257737
24TESK21.26767799
25STK101.19312425
26CDK71.19253929
27FER1.13485068
28CHUK1.12828778
29MAP2K21.11784489
30MAP2K11.11776849
31FGFR41.08064115
32NUAK11.07010952
33BCKDK1.05266113
34PTK61.03670371
35LMTK20.99996072
36PRKG20.97425537
37FRK0.94856546
38ERN10.93144935
39PBK0.92515959
40MYLK0.88756570
41SIK30.88619666
42PAK30.87350379
43RIPK10.86552656
44FYN0.83902647
45STK390.83605108
46RPS6KB10.81705678
47PRKCI0.79600296
48PDGFRB0.75734470
49IRAK20.75452673
50EIF2AK10.74603386
51SRPK10.73055123
52WNK40.71495323
53NEK10.70271397
54TESK10.70215038
55MTOR0.68078784
56TAF10.66701825
57PDK30.65483641
58PDK40.65483641
59TAOK10.65184030
60NME10.63950569
61DDR20.63845979
62ROCK20.63101881
63MAPKAPK20.61102683
64PIM20.60328873
65ICK0.58987186
66EEF2K0.57073859
67ZAP700.56831687
68TBK10.56149202
69CSF1R0.54287147
70MAP3K80.52455293
71BMX0.49526893
72PTK20.48237430
73SRC0.47923729
74PAK40.47035087
75CDK120.46057002
76EPHB10.45468437
77ERBB20.45358747
78PDPK10.44948608
79RPS6KA40.43877107
80PDK20.42064487
81RPS6KA20.41370153
82IKBKB0.38421338
83RET0.38299360
84EIF2AK20.37521888
85ROCK10.37389782
86IKBKE0.36287189
87MAP3K100.35983857
88HIPK20.35716711
89IRAK40.35078984
90DAPK10.34382766
91RPS6KL10.33603767
92RPS6KC10.33603767
93MAP3K30.33550822
94AKT20.33465313
95PDK10.33155860
96GRK60.32810008
97RPS6KB20.31722922
98TTN0.30799632
99MAP3K10.30751824
100DMPK0.30581944
101AURKA0.29714330
102LIMK10.29624444
103CSK0.29296194
104CAMKK10.28523706
105MELK0.28197540
106MAP3K130.28174206
107MINK10.26328169
108NTRK10.26049748
109MATK0.25791066
110PDGFRA0.25568210
111KSR10.25316979
112EGFR0.24983728
113AURKB0.24587263
114BRSK10.24310117
115TAOK20.24228044
116FGFR20.24144534
117CAMK2B0.23347649
118MAPK40.23091522
119PRPF4B0.22582599
120RPS6KA60.21957421
121ALK0.21808074
122BMPR20.20794650
123YES10.19886683
124MAPK80.18919724
125CDK190.18743944
126ARAF0.18146735
127TSSK60.17858095
128CAMK2D0.17777079
129PRKD20.17705170
130TYRO30.17633973
131PRKD10.17578482
132PRKCQ0.17155708
133PRKAA20.17099629
134PAK60.16422057
135MAPK110.16111034
136JAK20.15913042
137PRKCZ0.15844549
138MAPKAPK50.15536915
139PIK3CA0.15374774
140CDK60.14998304
141CAMK2G0.14910092
142FGR0.14785474
143CDK80.14452877
144MAP2K60.13927748
145LATS10.13491888
146PHKG10.13153726
147PHKG20.13153726
148PAK20.13075268
149RAF10.12830261
150CDK50.12608969
151MAP3K110.12089034
152RPS6KA10.12062774
153NME20.11882625
154OXSR10.11299596
155PAK10.11216826
156IGF1R0.10553239
157CDC42BPA0.09579329

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.32470165
2Gastric acid secretion_Homo sapiens_hsa049714.74362113
3Sulfur metabolism_Homo sapiens_hsa009204.68942233
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.24472261
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.13613472
6Collecting duct acid secretion_Homo sapiens_hsa049663.95983767
7Chemical carcinogenesis_Homo sapiens_hsa052043.76372790
8Glutathione metabolism_Homo sapiens_hsa004803.36659983
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.02695212
10Endometrial cancer_Homo sapiens_hsa052132.79206131
11Central carbon metabolism in cancer_Homo sapiens_hsa052302.56363793
12Acute myeloid leukemia_Homo sapiens_hsa052212.47356534
13Fat digestion and absorption_Homo sapiens_hsa049752.37158643
14Non-small cell lung cancer_Homo sapiens_hsa052232.20965132
15Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.13263042
16Longevity regulating pathway - mammal_Homo sapiens_hsa042111.97644225
17Proteasome_Homo sapiens_hsa030501.96532047
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93474034
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85842887
20Vitamin digestion and absorption_Homo sapiens_hsa049771.82029003
21mTOR signaling pathway_Homo sapiens_hsa041501.78423683
22Hepatitis C_Homo sapiens_hsa051601.72511640
23AMPK signaling pathway_Homo sapiens_hsa041521.72075521
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.70943584
25Linoleic acid metabolism_Homo sapiens_hsa005911.60512357
26ErbB signaling pathway_Homo sapiens_hsa040121.58603856
27Chronic myeloid leukemia_Homo sapiens_hsa052201.53090251
28Insulin signaling pathway_Homo sapiens_hsa049101.52368689
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50607057
30N-Glycan biosynthesis_Homo sapiens_hsa005101.48169590
31Nitrogen metabolism_Homo sapiens_hsa009101.48108391
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47310164
33Insulin resistance_Homo sapiens_hsa049311.40949186
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39358122
35Mineral absorption_Homo sapiens_hsa049781.38343535
36Glioma_Homo sapiens_hsa052141.37702538
37Fatty acid degradation_Homo sapiens_hsa000711.33570723
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31622210
39Pancreatic secretion_Homo sapiens_hsa049721.28779280
40Ether lipid metabolism_Homo sapiens_hsa005651.27523812
41Prostate cancer_Homo sapiens_hsa052151.26187563
42Inositol phosphate metabolism_Homo sapiens_hsa005621.24581237
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.23388034
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23196519
45Retinol metabolism_Homo sapiens_hsa008301.20441744
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19580353
47Renal cell carcinoma_Homo sapiens_hsa052111.17322753
48Steroid biosynthesis_Homo sapiens_hsa001001.11833030
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.10690608
50Other glycan degradation_Homo sapiens_hsa005111.09817445
51HIF-1 signaling pathway_Homo sapiens_hsa040661.08461388
52Propanoate metabolism_Homo sapiens_hsa006401.06512483
53Choline metabolism in cancer_Homo sapiens_hsa052311.05571308
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04109616
55Thyroid hormone synthesis_Homo sapiens_hsa049181.01188150
56Ribosome_Homo sapiens_hsa030101.00435370
57Pyruvate metabolism_Homo sapiens_hsa006201.00073395
58Prolactin signaling pathway_Homo sapiens_hsa049170.98933090
59Base excision repair_Homo sapiens_hsa034100.98356922
60Sphingolipid metabolism_Homo sapiens_hsa006000.97463383
61Sulfur relay system_Homo sapiens_hsa041220.96885069
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96705507
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96367037
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.90912309
65Melanoma_Homo sapiens_hsa052180.89368480
66Bile secretion_Homo sapiens_hsa049760.89317942
67Glycerolipid metabolism_Homo sapiens_hsa005610.87270472
68Notch signaling pathway_Homo sapiens_hsa043300.86307959
69Butanoate metabolism_Homo sapiens_hsa006500.85372389
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.85151274
71DNA replication_Homo sapiens_hsa030300.84701567
72Pancreatic cancer_Homo sapiens_hsa052120.82945684
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80072681
74Histidine metabolism_Homo sapiens_hsa003400.76666588
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76383979
76Carbon metabolism_Homo sapiens_hsa012000.76056803
77Phenylalanine metabolism_Homo sapiens_hsa003600.72646050
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70448121
79beta-Alanine metabolism_Homo sapiens_hsa004100.69499373
80Vitamin B6 metabolism_Homo sapiens_hsa007500.68696651
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68393193
82Fatty acid metabolism_Homo sapiens_hsa012120.67911917
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67355006
84RNA transport_Homo sapiens_hsa030130.67198364
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65784473
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65501908
87Oxidative phosphorylation_Homo sapiens_hsa001900.64875587
88B cell receptor signaling pathway_Homo sapiens_hsa046620.61790883
89Arginine biosynthesis_Homo sapiens_hsa002200.60627555
90Hepatitis B_Homo sapiens_hsa051610.60525970
91PPAR signaling pathway_Homo sapiens_hsa033200.58726202
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.57211434
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57092055
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.54063044
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.53725957
96Spliceosome_Homo sapiens_hsa030400.52411674
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52136556
98Glucagon signaling pathway_Homo sapiens_hsa049220.52119328
99Tight junction_Homo sapiens_hsa045300.51188945
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51050570
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.51030686
102Fanconi anemia pathway_Homo sapiens_hsa034600.49744984
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.48683096
104Colorectal cancer_Homo sapiens_hsa052100.46282032
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45561999
106Endocytosis_Homo sapiens_hsa041440.45147535
107Thyroid cancer_Homo sapiens_hsa052160.45115332
108Arachidonic acid metabolism_Homo sapiens_hsa005900.44340727
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44158408
110Pyrimidine metabolism_Homo sapiens_hsa002400.43555458
111Small cell lung cancer_Homo sapiens_hsa052220.42569144
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42395899
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42285544
114Alcoholism_Homo sapiens_hsa050340.42130168
115Tryptophan metabolism_Homo sapiens_hsa003800.40681780
116mRNA surveillance pathway_Homo sapiens_hsa030150.39724057
117Apoptosis_Homo sapiens_hsa042100.39458183
118Epstein-Barr virus infection_Homo sapiens_hsa051690.37973662
119Lysine degradation_Homo sapiens_hsa003100.37946354
120Fructose and mannose metabolism_Homo sapiens_hsa000510.37658720
121Dorso-ventral axis formation_Homo sapiens_hsa043200.37359359
122Pentose phosphate pathway_Homo sapiens_hsa000300.35045199
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34971103
124Viral carcinogenesis_Homo sapiens_hsa052030.33823668
125Tyrosine metabolism_Homo sapiens_hsa003500.32727404
126Hippo signaling pathway_Homo sapiens_hsa043900.32353780
127TGF-beta signaling pathway_Homo sapiens_hsa043500.31950344
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31417475
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31395892
130Lysosome_Homo sapiens_hsa041420.31084322
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.30223325
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30036275
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29193506
134Salivary secretion_Homo sapiens_hsa049700.28258591
135Peroxisome_Homo sapiens_hsa041460.26722961
136Biosynthesis of amino acids_Homo sapiens_hsa012300.22961355
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.21992824
138ABC transporters_Homo sapiens_hsa020100.21950524
139Fatty acid elongation_Homo sapiens_hsa000620.21282490
140Folate biosynthesis_Homo sapiens_hsa007900.20041869
141Starch and sucrose metabolism_Homo sapiens_hsa005000.19011159
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18906708
143Adherens junction_Homo sapiens_hsa045200.17988815
144Cardiac muscle contraction_Homo sapiens_hsa042600.14129728
145Bladder cancer_Homo sapiens_hsa052190.13968359
146Proteoglycans in cancer_Homo sapiens_hsa052050.13770675
147Estrogen signaling pathway_Homo sapiens_hsa049150.12888839
148Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12573869
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.11833270
150Salmonella infection_Homo sapiens_hsa051320.11715799
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.11094999
152Insulin secretion_Homo sapiens_hsa049110.10708991
153GnRH signaling pathway_Homo sapiens_hsa049120.09429134
154Metabolic pathways_Homo sapiens_hsa011000.08393862
155Long-term potentiation_Homo sapiens_hsa047200.08138938
156Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.07917873
157VEGF signaling pathway_Homo sapiens_hsa043700.07547400
158Renin secretion_Homo sapiens_hsa049240.07499658
159Shigellosis_Homo sapiens_hsa051310.07337048
160Galactose metabolism_Homo sapiens_hsa000520.07068149
161Cholinergic synapse_Homo sapiens_hsa047250.06075200
162Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.05479416
163Vibrio cholerae infection_Homo sapiens_hsa051100.05412173
164Selenocompound metabolism_Homo sapiens_hsa004500.04541034
165Focal adhesion_Homo sapiens_hsa045100.03431114

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