TFF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle remodeling (GO:0034374)9.75221606
2intestinal epithelial cell development (GO:0060576)9.21266665
3lung secretory cell differentiation (GO:0061140)8.12015839
4bile acid and bile salt transport (GO:0015721)7.99463182
5axonemal dynein complex assembly (GO:0070286)7.82814268
6intestinal absorption (GO:0050892)6.87239456
7hepatocyte apoptotic process (GO:0097284)6.60229953
8positive regulation of macrophage derived foam cell differentiation (GO:0010744)6.58679180
9maintenance of gastrointestinal epithelium (GO:0030277)6.34047340
10calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.09178276
11sulfation (GO:0051923)6.08895327
12regulation of guanylate cyclase activity (GO:0031282)5.89731978
13glandular epithelial cell differentiation (GO:0002067)5.83943176
14vitamin transmembrane transport (GO:0035461)5.81887283
15phosphatidylinositol acyl-chain remodeling (GO:0036149)5.73234379
16positive regulation of respiratory burst (GO:0060267)5.71006550
17cilium or flagellum-dependent cell motility (GO:0001539)5.66812356
18regulation of glucose import in response to insulin stimulus (GO:2001273)5.62237351
19phosphatidylserine acyl-chain remodeling (GO:0036150)5.47569562
20plasma lipoprotein particle remodeling (GO:0034369)5.47223899
21protein-lipid complex remodeling (GO:0034368)5.47223899
22macromolecular complex remodeling (GO:0034367)5.47223899
23regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.32383195
24primary alcohol catabolic process (GO:0034310)5.28257549
25ethanol oxidation (GO:0006069)5.27467990
26antibacterial humoral response (GO:0019731)5.15709103
27ethanol metabolic process (GO:0006067)5.05595510
28cilium movement (GO:0003341)5.04269527
29motile cilium assembly (GO:0044458)5.02670468
30antimicrobial humoral response (GO:0019730)4.98488661
31digestive system process (GO:0022600)4.90599757
32intestinal cholesterol absorption (GO:0030299)4.84764854
33phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.79729289
34positive regulation of cellular response to insulin stimulus (GO:1900078)4.73667819
35regulation of norepinephrine secretion (GO:0014061)4.64383107
36epoxygenase P450 pathway (GO:0019373)4.63788882
37epithelial structure maintenance (GO:0010669)4.62814425
38UDP-N-acetylglucosamine metabolic process (GO:0006047)4.55357423
39positive regulation of pseudopodium assembly (GO:0031274)4.55357045
40galactose catabolic process (GO:0019388)4.52890319
41pyrimidine-containing compound transmembrane transport (GO:0072531)4.46534069
42positive regulation of guanylate cyclase activity (GO:0031284)4.42886988
43plasma lipoprotein particle organization (GO:0071827)4.42497782
44oligosaccharide biosynthetic process (GO:0009312)4.41160293
45phosphatidylserine metabolic process (GO:0006658)4.38680470
46galactose metabolic process (GO:0006012)4.37497414
47protein-lipid complex subunit organization (GO:0071825)4.34635697
48proline biosynthetic process (GO:0006561)4.34549233
49bile acid metabolic process (GO:0008206)4.33183294
50epithelial cilium movement (GO:0003351)4.32475946
51glomerular filtration (GO:0003094)4.30777887
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.28507921
53phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.20152910
54O-glycan processing (GO:0016266)4.10182867
55phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.10098968
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09061813
57regulation of pseudopodium assembly (GO:0031272)4.07204726
58regulation of respiratory burst (GO:0060263)4.05100477
59negative regulation of keratinocyte proliferation (GO:0010839)4.02163165
60bundle of His cell to Purkinje myocyte communication (GO:0086069)3.97819999
61renal filtration (GO:0097205)3.90411734
62regulation of macrophage derived foam cell differentiation (GO:0010743)3.85126541
63regulation of bile acid biosynthetic process (GO:0070857)3.84559019
64regulation of systemic arterial blood pressure by hormone (GO:0001990)3.83932013
65regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.83932013
66endocrine process (GO:0050886)3.83932013
67fructose metabolic process (GO:0006000)3.81968346
68tumor necrosis factor-mediated signaling pathway (GO:0033209)3.78701232
69regulation of hydrogen peroxide metabolic process (GO:0010310)3.75337640
70lipoprotein transport (GO:0042953)3.72021091
71negative regulation of cell fate commitment (GO:0010454)3.65832744
72alditol phosphate metabolic process (GO:0052646)3.63040918
73regulation of cellular extravasation (GO:0002691)3.61209858
74ATP synthesis coupled proton transport (GO:0015986)3.58720668
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58720668
76lung epithelial cell differentiation (GO:0060487)3.58699278
77fat-soluble vitamin biosynthetic process (GO:0042362)3.57359275
78lung cell differentiation (GO:0060479)3.57196817
79regulation of cGMP biosynthetic process (GO:0030826)3.57121483
80regulation of viral entry into host cell (GO:0046596)3.56571769
81eosinophil chemotaxis (GO:0048245)3.54684668
82receptor guanylyl cyclase signaling pathway (GO:0007168)3.52433614
83drug metabolic process (GO:0017144)3.52285758
84exogenous drug catabolic process (GO:0042738)3.52011557
85mucosal immune response (GO:0002385)3.51091245
86sulfur amino acid catabolic process (GO:0000098)3.46471152
87regulation of systemic arterial blood pressure (GO:0003073)3.45032901
88renal system process involved in regulation of blood volume (GO:0001977)3.44772288
89diterpenoid biosynthetic process (GO:0016102)3.44681268
90complement activation, classical pathway (GO:0006958)3.42855642
91glutathione biosynthetic process (GO:0006750)3.35826998
92phosphatidylcholine acyl-chain remodeling (GO:0036151)3.33144591
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32670419
94transcytosis (GO:0045056)3.32425005
95organ or tissue specific immune response (GO:0002251)3.31077580
96positive regulation of glycoprotein metabolic process (GO:1903020)3.29551348
97positive regulation of glycoprotein biosynthetic process (GO:0010560)3.28765391
98flavonoid metabolic process (GO:0009812)3.28198323
99nonribosomal peptide biosynthetic process (GO:0019184)3.28189063
100drug catabolic process (GO:0042737)3.27953065
101primary alcohol metabolic process (GO:0034308)3.26699313
102N-acetylglucosamine metabolic process (GO:0006044)3.26391238
103positive regulation of epidermal cell differentiation (GO:0045606)3.24591363
104GDP-mannose metabolic process (GO:0019673)3.24096441
105diacylglycerol metabolic process (GO:0046339)3.22095449
106hormone catabolic process (GO:0042447)3.21808957
107glucuronate metabolic process (GO:0019585)3.21446817
108uronic acid metabolic process (GO:0006063)3.21446817
109multicellular organismal water homeostasis (GO:0050891)3.18553662
110axoneme assembly (GO:0035082)3.18382128
111actin filament depolymerization (GO:0030042)3.17601504
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16976141
113peptide catabolic process (GO:0043171)3.16642109
114regulation of vitamin metabolic process (GO:0030656)3.16514165
115production of molecular mediator involved in inflammatory response (GO:0002532)3.15803148
116purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.15673800
1173-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.15673800
118regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.15406319
119eosinophil migration (GO:0072677)3.15295731
120cellular glucuronidation (GO:0052695)3.15254961
121regulation of cytokine secretion involved in immune response (GO:0002739)3.15114261
122proline metabolic process (GO:0006560)3.13493663
123angiotensin maturation (GO:0002003)3.12618896
124vitamin transport (GO:0051180)3.11923843
125sphingomyelin metabolic process (GO:0006684)3.11327847
126regulation of keratinocyte proliferation (GO:0010837)3.10734497
127regulation of actin nucleation (GO:0051125)3.10517681
128negative regulation of epidermal cell differentiation (GO:0045605)3.10470287
129cell differentiation involved in embryonic placenta development (GO:0060706)3.06603434
130sodium ion homeostasis (GO:0055078)3.06601559
131urea metabolic process (GO:0019627)3.06445054
132urea cycle (GO:0000050)3.06445054
133negative regulation of protein tyrosine kinase activity (GO:0061099)3.05244327
134leukocyte tethering or rolling (GO:0050901)3.04811365
135phosphatidic acid metabolic process (GO:0046473)3.04773777
136phosphatidic acid biosynthetic process (GO:0006654)3.04773777
137sperm capacitation (GO:0048240)3.03172216
138* digestion (GO:0007586)3.02872436
139excretion (GO:0007588)3.02202296
140nucleoside diphosphate biosynthetic process (GO:0009133)3.01744136
141glucose 6-phosphate metabolic process (GO:0051156)3.00557079
142positive regulation of chemokine secretion (GO:0090197)2.98888982
143antigen processing and presentation of endogenous antigen (GO:0019883)2.98374214
144adhesion of symbiont to host cell (GO:0044650)2.97073465
145virion attachment to host cell (GO:0019062)2.97073465
146regulation of cGMP metabolic process (GO:0030823)2.95778559
147retinol metabolic process (GO:0042572)2.95675366
148glycolipid catabolic process (GO:0019377)2.94893012
149positive regulation of Cdc42 GTPase activity (GO:0043089)2.94451389
150glutathione metabolic process (GO:0006749)2.94401578
151glycosphingolipid catabolic process (GO:0046479)2.93952895
152vitamin A metabolic process (GO:0006776)2.90531288
153positive regulation of glucose import (GO:0046326)2.89846705
154regulation of hormone biosynthetic process (GO:0046885)2.89564992
155desmosome organization (GO:0002934)2.86575036
156positive regulation of cytokine production involved in immune response (GO:0002720)2.85922878
157columnar/cuboidal epithelial cell development (GO:0002066)2.85606894
158glutathione derivative biosynthetic process (GO:1901687)2.85521334
159glutathione derivative metabolic process (GO:1901685)2.85521334
160cysteine metabolic process (GO:0006534)2.85476105
161protein O-linked glycosylation (GO:0006493)2.85185762
162defense response to Gram-positive bacterium (GO:0050830)2.84088020
163cellular response to fatty acid (GO:0071398)2.83656683
164nucleotide transmembrane transport (GO:1901679)2.83339544
165arginine metabolic process (GO:0006525)2.82929191
166negative regulation of T cell differentiation in thymus (GO:0033085)2.82704121
167ventricular cardiac muscle cell action potential (GO:0086005)2.82409527
168regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.81480141
169regulation of chemokine secretion (GO:0090196)2.81358284
170positive regulation of glucose transport (GO:0010828)2.80218999
171glycosylceramide metabolic process (GO:0006677)2.78989100
172glutamine family amino acid biosynthetic process (GO:0009084)2.76981753
173nitrogen cycle metabolic process (GO:0071941)2.76658177
174purine deoxyribonucleotide catabolic process (GO:0009155)2.74978902
175cardiac conduction (GO:0061337)2.72601908
176NADH metabolic process (GO:0006734)2.64364640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.09336760
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.73204435
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.31641865
4* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.25388830
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.62077857
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.60569374
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60055172
8ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse3.18353565
9SOX2_27498859_Chip-Seq_STOMACH_Mouse3.06540401
10ESR1_21235772_ChIP-Seq_MCF-7_Human3.02975989
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.99998820
12GATA4_25053715_ChIP-Seq_YYC3_Human2.87622056
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84300911
14GATA6_25053715_ChIP-Seq_YYC3_Human2.71584458
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.66897293
16* SOX2_20726797_ChIP-Seq_SW620_Human2.64598853
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.50894853
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.39693585
19* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28660496
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.20978844
21* STAT1_20625510_ChIP-Seq_HELA_Human2.06559755
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.06469419
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97733603
24ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.92835883
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.80306601
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71381821
27* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64962256
28FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.64177028
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63880387
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62667199
31LXR_22292898_ChIP-Seq_THP-1_Human1.61193816
32ZNF263_19887448_ChIP-Seq_K562_Human1.60171337
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.57595903
34AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.56522956
35RACK7_27058665_Chip-Seq_MCF-7_Human1.54623124
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47206517
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46290748
38* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44937387
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.44032547
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42506777
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40025047
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39158771
43* FOXA1_25552417_ChIP-Seq_VCAP_Human1.38639734
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37373678
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37357296
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35980210
47KLF5_25053715_ChIP-Seq_YYC3_Human1.33312751
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33023773
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30944479
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30889779
51CTCF_27219007_Chip-Seq_Bcells_Human1.29829386
52AR_21909140_ChIP-Seq_LNCAP_Human1.29561662
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29337938
54* RUNX1_27514584_Chip-Seq_MCF-7_Human1.28195850
55CTCF_20526341_ChIP-Seq_ESCs_Human1.28060451
56GATA2_19941826_ChIP-Seq_K562_Human1.27504990
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25819937
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24551558
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22894922
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21680244
61TP63_22573176_ChIP-Seq_HFKS_Human1.16895525
62CLOCK_20551151_ChIP-Seq_293T_Human1.15794724
63PHF8_20622854_ChIP-Seq_HELA_Human1.15432438
64ATF3_27146783_Chip-Seq_COLON_Human1.14709495
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13227433
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13069816
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12981454
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12595104
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12230342
70GATA1_19941826_ChIP-Seq_K562_Human1.11918755
71* SA1_27219007_Chip-Seq_Bcells_Human1.10694198
72AHR_22903824_ChIP-Seq_MCF-7_Human1.09849058
73BCL6_27268052_Chip-Seq_Bcells_Human1.09380425
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08750550
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08441598
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08284685
77BCOR_27268052_Chip-Seq_Bcells_Human1.07466091
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06904240
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.05826289
80* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05682667
81BCAT_22108803_ChIP-Seq_LS180_Human1.05168455
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04868225
83BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04069171
84* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03725086
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03481674
86OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03235710
87* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03155498
88SMC4_20622854_ChIP-Seq_HELA_Human1.02585931
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02217974
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00779773
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00558549
92GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00281496
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.99375478
94BP1_19119308_ChIP-ChIP_Hs578T_Human0.97131498
95* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96895850
96DROSHA_22980978_ChIP-Seq_HELA_Human0.96769630
97* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96508425
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95505935
99E2F1_20622854_ChIP-Seq_HELA_Human0.94632079
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.94081871
101JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93581142
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92027319
103NANOG_20526341_ChIP-Seq_ESCs_Human0.91896765
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91392340
105HNF4A_19822575_ChIP-Seq_HepG2_Human0.90884637
106P68_20966046_ChIP-Seq_HELA_Human0.90769353
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90690883
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89352789
109* CEBPB_22108803_ChIP-Seq_LS180_Human0.89351469
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89044485
111SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88655180
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88445179
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88106279
114* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87660018
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87475413
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86653952
117P300_27268052_Chip-Seq_Bcells_Human0.86159100
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85780814
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85532845
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.85469578
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.85264705
122NANOG_18692474_ChIP-Seq_MEFs_Mouse0.83799013
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82820467
124CDX2_22108803_ChIP-Seq_LS180_Human0.82762398
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82482438
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82419700
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.82383533
128SOX2_21211035_ChIP-Seq_LN229_Human0.81434951
129CREB1_26743006_Chip-Seq_LNCaP_Human0.81320317
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81008838
131* MYC_27129775_Chip-Seq_CORNEA_Mouse0.79902395
132EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.79007942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.81384910
2MP0001666_abnormal_nutrient_absorption4.78945210
3MP0004264_abnormal_extraembryonic_tissu4.51668544
4MP0003868_abnormal_feces_composition4.36965655
5MP0001873_stomach_inflammation3.90676102
6MP0002139_abnormal_hepatobiliary_system3.81752168
7MP0003866_abnormal_defecation3.72131237
8MP0000490_abnormal_crypts_of3.71931779
9MP0005085_abnormal_gallbladder_physiolo3.39847647
10MP0010234_abnormal_vibrissa_follicle3.36891801
11* MP0010155_abnormal_intestine_physiology3.14881886
12MP0001663_abnormal_digestive_system3.05676250
13MP0000462_abnormal_digestive_system3.04079197
14MP0004043_abnormal_pH_regulation2.96413498
15MP0008875_abnormal_xenobiotic_pharmacok2.77571653
16MP0003252_abnormal_bile_duct2.61189861
17MP0005365_abnormal_bile_salt2.56692940
18MP0005381_digestive/alimentary_phenotyp2.55316535
19MP0005666_abnormal_adipose_tissue2.30674934
20MP0001664_abnormal_digestion2.27034734
21* MP0000477_abnormal_intestine_morphology2.25971822
22MP0002277_abnormal_respiratory_mucosa2.09542031
23MP0000537_abnormal_urethra_morphology2.07855124
24MP0003806_abnormal_nucleotide_metabolis2.07764373
25MP0002876_abnormal_thyroid_physiology2.02904649
26MP0005409_darkened_coat_color2.02741438
27MP0004147_increased_porphyrin_level2.00798184
28MP0004019_abnormal_vitamin_homeostasis1.98139797
29MP0003705_abnormal_hypodermis_morpholog1.91921593
30MP0000465_gastrointestinal_hemorrhage1.83775751
31MP0003183_abnormal_peptide_metabolism1.83628382
32MP0003191_abnormal_cellular_cholesterol1.79682533
33MP0008004_abnormal_stomach_pH1.72519968
34MP0010352_gastrointestinal_tract_polyps1.68364274
35MP0009840_abnormal_foam_cell1.66080360
36MP0010329_abnormal_lipoprotein_level1.65959895
37MP0003300_gastrointestinal_ulcer1.64542609
38MP0000566_synostosis1.59777456
39MP0002132_abnormal_respiratory_system1.57446975
40MP0009780_abnormal_chondrocyte_physiolo1.52706850
41MP0004858_abnormal_nervous_system1.45004229
42MP0005451_abnormal_body_composition1.43468977
43MP0002822_catalepsy1.40101879
44MP0002653_abnormal_ependyma_morphology1.31989915
45MP0005448_abnormal_energy_balance1.28792676
46MP0005375_adipose_tissue_phenotype1.27483023
47MP0003879_abnormal_hair_cell1.19880600
48MP0000681_abnormal_thyroid_gland1.18472126
49MP0003724_increased_susceptibility_to1.16014961
50MP0003878_abnormal_ear_physiology1.13041338
51MP0005377_hearing/vestibular/ear_phenot1.13041338
52MP0009643_abnormal_urine_homeostasis1.11195309
53MP0003303_peritoneal_inflammation1.10624496
54MP0005332_abnormal_amino_acid1.10133607
55MP0002118_abnormal_lipid_homeostasis1.09770403
56MP0001849_ear_inflammation1.08482277
57MP0001756_abnormal_urination1.07181478
58MP0001188_hyperpigmentation1.04419552
59MP0003123_paternal_imprinting1.02584927
60MP0002909_abnormal_adrenal_gland1.01598072
61MP0002796_impaired_skin_barrier0.96903135
62MP0005166_decreased_susceptibility_to0.96664461
63MP0002896_abnormal_bone_mineralization0.96096375
64MP0000470_abnormal_stomach_morphology0.95795642
65MP0001764_abnormal_homeostasis0.95591788
66MP0004185_abnormal_adipocyte_glucose0.93877848
67MP0002166_altered_tumor_susceptibility0.92663621
68MP0001790_abnormal_immune_system0.90809143
69MP0005387_immune_system_phenotype0.90809143
70MP0006054_spinal_hemorrhage0.89928804
71MP0008872_abnormal_physiological_respon0.88328766
72MP0002138_abnormal_hepatobiliary_system0.86109752
73MP0000538_abnormal_urinary_bladder0.85468127
74MP0005310_abnormal_salivary_gland0.84577159
75MP0005083_abnormal_biliary_tract0.83604055
76MP0000609_abnormal_liver_physiology0.83465026
77MP0005025_abnormal_response_to0.81488738
78MP0005334_abnormal_fat_pad0.77677364
79MP0000383_abnormal_hair_follicle0.77220056
80MP0006082_CNS_inflammation0.75084179
81MP0010030_abnormal_orbit_morphology0.74755727
82MP0001485_abnormal_pinna_reflex0.72974031
83MP0001881_abnormal_mammary_gland0.72910618
84MP0002249_abnormal_larynx_morphology0.72720346
85MP0003329_amyloid_beta_deposits0.72596061
86* MP0001845_abnormal_inflammatory_respons0.71080016
87MP0001765_abnormal_ion_homeostasis0.68259333
88MP0005058_abnormal_lysosome_morphology0.67207303
89MP0001835_abnormal_antigen_presentation0.66726150
90MP0005319_abnormal_enzyme/_coenzyme0.66570471
91MP0005408_hypopigmentation0.63606735
92MP0003718_maternal_effect0.63444671
93MP0005076_abnormal_cell_differentiation0.62566181
94MP0004947_skin_inflammation0.61210330
95MP0002148_abnormal_hypersensitivity_rea0.61148741
96MP0010678_abnormal_skin_adnexa0.60964801
97MP0000013_abnormal_adipose_tissue0.60491536
98MP0003828_pulmonary_edema0.60130374
99MP0009379_abnormal_foot_pigmentation0.59827232
100MP0000858_altered_metastatic_potential0.59824127
101MP0005084_abnormal_gallbladder_morpholo0.58849174
102MP0000249_abnormal_blood_vessel0.57820925
103MP0003638_abnormal_response/metabolism_0.57603661
104MP0001501_abnormal_sleep_pattern0.57334134
105MP0001533_abnormal_skeleton_physiology0.57207702
106MP0004484_altered_response_of0.56490171
107MP0005584_abnormal_enzyme/coenzyme_acti0.55763938
108MP0004270_analgesia0.54324526
109MP0003075_altered_response_to0.53147566
110MP0002089_abnormal_postnatal_growth/wei0.52865563
111MP0009053_abnormal_anal_canal0.51408909
112MP0009642_abnormal_blood_homeostasis0.50229792
113MP0010386_abnormal_urinary_bladder0.50125278
114MP0003453_abnormal_keratinocyte_physiol0.50001576
115MP0000467_abnormal_esophagus_morphology0.49185145
116MP0001440_abnormal_grooming_behavior0.49009255
117MP0005636_abnormal_mineral_homeostasis0.47597489
118MP0002136_abnormal_kidney_physiology0.47565294
119MP0004782_abnormal_surfactant_physiolog0.47329742
120MP0005501_abnormal_skin_physiology0.47224316
121MP0005167_abnormal_blood-brain_barrier0.46235168
122MP0002254_reproductive_system_inflammat0.46015428
123MP0002098_abnormal_vibrissa_morphology0.43847586
124MP0001958_emphysema0.42808434
125MP0001216_abnormal_epidermal_layer0.41398890
126MP0003656_abnormal_erythrocyte_physiolo0.41261463
127MP0003315_abnormal_perineum_morphology0.40350975
128MP0000678_abnormal_parathyroid_gland0.40309149
129MP0009785_altered_susceptibility_to0.40104834
130MP0003283_abnormal_digestive_organ0.39951766
131MP0005023_abnormal_wound_healing0.38765686
132MP0008873_increased_physiological_sensi0.38425930
133MP0000598_abnormal_liver_morphology0.37067889
134MP0008469_abnormal_protein_level0.36115347

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.98165439
2Abnormal respiratory motile cilium morphology (HP:0005938)6.90993982
3Abnormal respiratory epithelium morphology (HP:0012253)6.90993982
4Abnormal respiratory motile cilium physiology (HP:0012261)6.89762106
5Rhinitis (HP:0012384)6.71688866
6Abnormal ciliary motility (HP:0012262)6.56691806
7Dynein arm defect of respiratory motile cilia (HP:0012255)6.42314193
8Absent/shortened dynein arms (HP:0200106)6.42314193
9Chronic bronchitis (HP:0004469)6.10767144
10Hyperactive renin-angiotensin system (HP:0000841)5.97258667
11Micronodular cirrhosis (HP:0001413)5.74712082
12Nasal polyposis (HP:0100582)5.55630647
13Bronchiectasis (HP:0002110)5.37090469
14Ileus (HP:0002595)5.31330668
15Abnormality of the nasal mucosa (HP:0000433)5.18888638
16Abdominal distention (HP:0003270)4.99558689
17Decreased circulating renin level (HP:0003351)4.84410918
18Right ventricular cardiomyopathy (HP:0011663)4.63545821
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.58182629
20Late onset (HP:0003584)4.41342044
21Esophageal varix (HP:0002040)4.07466884
22Abnormality of the vitamin B12 metabolism (HP:0004341)3.99705498
23Abnormality of renin-angiotensin system (HP:0000847)3.95416600
24Ventricular fibrillation (HP:0001663)3.93473822
25Congenital sensorineural hearing impairment (HP:0008527)3.89375357
26Syncope (HP:0001279)3.81170893
27Ketoacidosis (HP:0001993)3.81153501
28Abnormality of vitamin B metabolism (HP:0004340)3.78623723
29Bronchitis (HP:0012387)3.69777587
30Systemic lupus erythematosus (HP:0002725)3.68343231
31Chronic sinusitis (HP:0011109)3.47396131
32Recurrent sinusitis (HP:0011108)3.41845649
33Abnormality of vitamin metabolism (HP:0100508)3.37958304
34Bundle branch block (HP:0011710)3.26458704
35Malnutrition (HP:0004395)3.26404590
36Hyperparathyroidism (HP:0000843)3.25349547
37Alkalosis (HP:0001948)3.21994978
38Prolonged QT interval (HP:0001657)3.19203246
39Intrahepatic cholestasis (HP:0001406)3.15112146
40Posterior subcapsular cataract (HP:0007787)3.14506630
41Abnormality of monocarboxylic acid metabolism (HP:0010996)3.13804225
42Glycosuria (HP:0003076)3.02967033
43Abnormality of urine glucose concentration (HP:0011016)3.02967033
44Hypobetalipoproteinemia (HP:0003563)2.99471102
45Flat acetabular roof (HP:0003180)2.99146609
46Chronic otitis media (HP:0000389)2.98837498
47Hypercortisolism (HP:0001578)2.98790453
48Xanthomatosis (HP:0000991)2.95988892
49Metabolic alkalosis (HP:0200114)2.92648265
50Hyperaldosteronism (HP:0000859)2.91396388
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.87759026
52Abnormality of chloride homeostasis (HP:0011422)2.87298046
53Fat malabsorption (HP:0002630)2.84961811
54Palpitations (HP:0001962)2.82310492
55Woolly hair (HP:0002224)2.81328059
56Conjunctival hamartoma (HP:0100780)2.80954716
57Recurrent otitis media (HP:0000403)2.75753550
58Confusion (HP:0001289)2.72946046
59Increased muscle lipid content (HP:0009058)2.72894733
60Infertility (HP:0000789)2.71907008
61Hyperammonemia (HP:0001987)2.66437369
62Hypoglycemic coma (HP:0001325)2.63505358
63Ketosis (HP:0001946)2.62742332
64Generalized aminoaciduria (HP:0002909)2.62046878
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60380232
66Insulin resistance (HP:0000855)2.57359304
67Glomerulonephritis (HP:0000099)2.50446661
68Chronic diarrhea (HP:0002028)2.50123651
69Bone cyst (HP:0012062)2.49436944
70Increased intramyocellular lipid droplets (HP:0012240)2.48727259
71Hydroxyprolinuria (HP:0003080)2.46788925
72Abnormality of proline metabolism (HP:0010907)2.46788925
73Conjugated hyperbilirubinemia (HP:0002908)2.45960083
74Male infertility (HP:0003251)2.45691338
75Chorioretinal atrophy (HP:0000533)2.43144855
76Abnormality of glycolysis (HP:0004366)2.42751437
77Increased serum pyruvate (HP:0003542)2.42751437
78Hypotension (HP:0002615)2.42716995
79Lethargy (HP:0001254)2.39827729
80Multiple lipomas (HP:0001012)2.38573207
81Abnormality of endocrine pancreas physiology (HP:0012093)2.37640981
82Abnormality of the pancreatic islet cells (HP:0006476)2.37640981
83Abnormal foot bone ossification (HP:0010675)2.35868314
84Protuberant abdomen (HP:0001538)2.35761914
85Renal salt wasting (HP:0000127)2.35371633
86Acute encephalopathy (HP:0006846)2.35019046
87Thin bony cortex (HP:0002753)2.31452930
88Hepatic necrosis (HP:0002605)2.30156361
89Hemorrhage of the eye (HP:0011885)2.29308293
90Dicarboxylic aciduria (HP:0003215)2.29245134
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29245134
92Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26499530
93Pheochromocytoma (HP:0002666)2.23887752
94Hypolipoproteinemia (HP:0010981)2.23850839
95Pili torti (HP:0003777)2.21798421
96Hyponatremia (HP:0002902)2.20824517
97Hyperkalemia (HP:0002153)2.20561950
98Neoplasm of the rectum (HP:0100743)2.18573403
99Nausea (HP:0002018)2.18233513
100Neuroendocrine neoplasm (HP:0100634)2.17244037
101Abnormality of purine metabolism (HP:0004352)2.16893132
102Abnormality of fatty-acid metabolism (HP:0004359)2.16671576
103Pigmentary retinal degeneration (HP:0001146)2.15485571
104Lipid accumulation in hepatocytes (HP:0006561)2.14229444
105Exocrine pancreatic insufficiency (HP:0001738)2.13925056
106Proximal tubulopathy (HP:0000114)2.13679677
107Abnormality of the gastric mucosa (HP:0004295)2.11802603
108Abnormal mitochondria in muscle tissue (HP:0008316)2.10859644
109Complement deficiency (HP:0004431)2.10582917
110Abnormal EKG (HP:0003115)2.07609981
111Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06783957
112Nephritis (HP:0000123)2.06730131
113Mitochondrial inheritance (HP:0001427)2.06373176
114Rhabdomyolysis (HP:0003201)2.05710057
115Abnormality of small intestinal villus morphology (HP:0011472)2.04622617
116Villous atrophy (HP:0011473)2.04622617
117Abnormality of complement system (HP:0005339)2.04260770
118Recurrent bronchitis (HP:0002837)2.04097267
119Hyperphosphatemia (HP:0002905)2.02825507
120Acute necrotizing encephalopathy (HP:0006965)2.01122437
121Widely patent fontanelles and sutures (HP:0004492)1.99051037
122Hyperglycinuria (HP:0003108)1.98164036
123Pustule (HP:0200039)1.97530202
124Ventricular arrhythmia (HP:0004308)1.96601283
125Acanthocytosis (HP:0001927)1.95608122
126Atelectasis (HP:0100750)1.94525865
127Gastrointestinal dysmotility (HP:0002579)1.94522276
128Neoplasm of the small intestine (HP:0100833)1.93601058
129Hyperphosphaturia (HP:0003109)1.93502573
130Increased purine levels (HP:0004368)1.92785013
131Hyperuricemia (HP:0002149)1.92785013
132Eczematoid dermatitis (HP:0000976)1.92456897
133Biliary tract neoplasm (HP:0100574)1.92425602
134Steatorrhea (HP:0002570)1.92313770
135Deep venous thrombosis (HP:0002625)1.91554224
136Hypercholesterolemia (HP:0003124)1.88928215
137Cerebral edema (HP:0002181)1.87775317
138Growth hormone excess (HP:0000845)1.87382111
139Hypokalemia (HP:0002900)1.86783239
140Abnormal biliary tract morphology (HP:0012440)1.85075579
141Abnormal hair laboratory examination (HP:0003328)1.84100305
142Symptomatic seizures (HP:0011145)1.82989146
143Megaloblastic anemia (HP:0001889)1.81975630
144Hyperlipoproteinemia (HP:0010980)1.80736167
145Occipital encephalocele (HP:0002085)1.80029764
146Hepatocellular necrosis (HP:0001404)1.79836106
147Rectal prolapse (HP:0002035)1.78661677
148Increased hepatocellular lipid droplets (HP:0006565)1.78160254
149Wide cranial sutures (HP:0010537)1.78126229
150Esophageal neoplasm (HP:0100751)1.77735870
151Neoplasm of head and neck (HP:0012288)1.77735870
152Adrenal overactivity (HP:0002717)1.74580452
153Abnormal glucose tolerance (HP:0001952)1.73743781
154Abnormality of potassium homeostasis (HP:0011042)1.72480714
155Abnormal tarsal ossification (HP:0008369)1.71685105
156Hypophosphatemia (HP:0002148)1.71521477
157Abnormality of sodium homeostasis (HP:0010931)1.71233242
158Gout (HP:0001997)1.70273054
159Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69733412
160Dehydration (HP:0001944)1.68817517
161Abnormality of the distal phalanges of the toes (HP:0010182)1.62848818
162Vascular calcification (HP:0004934)1.57750006
163Renal tubular acidosis (HP:0001947)1.56559927
164Nephrolithiasis (HP:0000787)1.55576434
165Flattened epiphyses (HP:0003071)1.54481416
166Stridor (HP:0010307)1.49051664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.94065492
2NME15.93630731
3ACVR1B4.48387024
4MAPK154.21360631
5MAP2K23.93583575
6RPS6KB23.83665879
7MST42.97327501
8LMTK22.70735811
9MST1R2.68306601
10PTK62.47183829
11ERN12.44408823
12BLK2.27682428
13MAP2K62.00371973
14TAOK11.99080301
15TEC1.97646298
16PIK3CA1.95867473
17TESK11.89919303
18MAP3K111.86867778
19STK241.83152259
20MAP3K21.77687191
21EPHA31.76942598
22FGFR41.76685796
23PRKG21.75602240
24MAP2K11.72594137
25CAMK2D1.70342027
26CAMK2B1.65774369
27MAP3K121.65525367
28EPHB21.61353301
29GRK61.58407348
30EPHB11.54027072
31SMG11.53648966
32EEF2K1.53484072
33TRIB31.52917843
34MYLK1.47548711
35KSR21.40005163
36CAMK2G1.36557818
37TYK21.34950164
38PKN21.31244099
39MAP3K101.19387860
40PIM21.13864177
41PAK41.11427882
42MAP3K31.05028929
43TAOK31.02794236
44PTK21.00509436
45FGFR30.88232826
46CDC42BPA0.86530893
47ILK0.86109565
48MAP3K80.85921300
49NME20.84650000
50MAP3K10.77877546
51MAP3K70.77028618
52LIMK10.74037113
53LRRK20.73222587
54MET0.72771529
55FER0.71667174
56NUAK10.71236519
57LATS10.70072608
58CSK0.69460123
59TESK20.68414084
60MAPK110.68389130
61RIPK10.65692462
62ERBB20.62487688
63ZAP700.60003243
64NEK60.59257914
65IKBKE0.57995997
66RIPK40.57277717
67MAPKAPK30.57110475
68PRKCQ0.56730077
69NLK0.56486658
70STK100.54422756
71PRKCI0.54108444
72RET0.53020090
73IRAK10.52727635
74DYRK1B0.52549459
75MUSK0.52056495
76ABL20.51069206
77MAP3K60.49656751
78PAK10.49431845
79TBK10.48178062
80MAP4K10.47183701
81PAK30.45751451
82STK390.45579841
83PBK0.44072734
84PDK40.43543106
85PDK30.43543106
86SIK10.43462563
87CAMK10.43349186
88DAPK30.42479886
89TAOK20.42270686
90YES10.41021732
91SCYL20.41016588
92PRKCA0.40967038
93SRC0.40286102
94MAPKAPK20.40112534
95GRK10.39849712
96BMPR20.39312730
97CSNK1A10.39282698
98RPS6KA20.37365018
99ITK0.36777945
100AKT30.36573138
101CAMK2A0.35300261
102DMPK0.35034103
103BMX0.34621000
104PRKACG0.31878136
105JAK10.31736341
106TLK10.31436078
107CASK0.31434345
108PDPK10.28752654
109HIPK20.28515081
110DAPK20.27611516
111CAMKK10.27017619
112ERBB40.25077532
113PRKCE0.24824334
114PRKAA20.24424820
115MAP2K30.24031634
116PRKCD0.23174679
117KDR0.23064751
118EPHA20.22838301
119BCKDK0.22788969
120CDK190.22512902
121OXSR10.21425160
122CHUK0.21311685
123FYN0.20215090
124MATK0.19587619
125CDK60.17391438
126EIF2AK10.17284456
127SGK10.16949039
128JAK20.16947953
129DDR20.16751348
130PDK10.16728605
131ICK0.16723373
132WNK40.16699257
133LYN0.16588086
134CSNK1G30.15725787
135PRKCZ0.15405080
136IGF1R0.14624864
137TTK0.14534835
138EPHA40.13242076

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.70502306
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45623710
3Sulfur metabolism_Homo sapiens_hsa009203.36932963
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.36022547
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.28893410
6Linoleic acid metabolism_Homo sapiens_hsa005913.15408575
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64616181
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.56411525
9Histidine metabolism_Homo sapiens_hsa003402.36555219
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24932980
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.07927602
12Phenylalanine metabolism_Homo sapiens_hsa003602.05727681
13Tryptophan metabolism_Homo sapiens_hsa003801.98972986
14Arachidonic acid metabolism_Homo sapiens_hsa005901.88149403
15Fatty acid degradation_Homo sapiens_hsa000711.85446488
16Nitrogen metabolism_Homo sapiens_hsa009101.83293662
17PPAR signaling pathway_Homo sapiens_hsa033201.80209568
18Bile secretion_Homo sapiens_hsa049761.77475363
19Fructose and mannose metabolism_Homo sapiens_hsa000511.77158925
20Pyruvate metabolism_Homo sapiens_hsa006201.73765279
21Mineral absorption_Homo sapiens_hsa049781.70529794
22Ether lipid metabolism_Homo sapiens_hsa005651.69171286
23Galactose metabolism_Homo sapiens_hsa000521.65424132
24Tyrosine metabolism_Homo sapiens_hsa003501.60954049
25Asthma_Homo sapiens_hsa053101.60581527
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54702853
27Oxidative phosphorylation_Homo sapiens_hsa001901.52550652
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.51924758
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50043488
30Arginine and proline metabolism_Homo sapiens_hsa003301.47453296
31Glutathione metabolism_Homo sapiens_hsa004801.45538377
32Arginine biosynthesis_Homo sapiens_hsa002201.44520487
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44195193
34Parkinsons disease_Homo sapiens_hsa050121.37346181
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32376148
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27138513
37Pancreatic secretion_Homo sapiens_hsa049721.26954431
38Renin-angiotensin system_Homo sapiens_hsa046141.26334210
39Pentose phosphate pathway_Homo sapiens_hsa000301.23060272
40Glycerolipid metabolism_Homo sapiens_hsa005611.22447667
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12227745
42beta-Alanine metabolism_Homo sapiens_hsa004101.10550098
43Autoimmune thyroid disease_Homo sapiens_hsa053201.09732051
44Alzheimers disease_Homo sapiens_hsa050101.09359770
45Starch and sucrose metabolism_Homo sapiens_hsa005001.05612466
46Allograft rejection_Homo sapiens_hsa053301.03014229
47Vibrio cholerae infection_Homo sapiens_hsa051101.02532076
48Carbon metabolism_Homo sapiens_hsa012001.02453070
49Sphingolipid metabolism_Homo sapiens_hsa006001.00918158
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98404077
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96278158
52Staphylococcus aureus infection_Homo sapiens_hsa051500.95835347
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94128251
54Vitamin digestion and absorption_Homo sapiens_hsa049770.92937691
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.90994325
56Graft-versus-host disease_Homo sapiens_hsa053320.90122262
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89701774
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87767279
59Type I diabetes mellitus_Homo sapiens_hsa049400.86390589
60Tight junction_Homo sapiens_hsa045300.84635426
61Protein digestion and absorption_Homo sapiens_hsa049740.83887622
62Hepatitis C_Homo sapiens_hsa051600.83701516
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.81734862
64Butanoate metabolism_Homo sapiens_hsa006500.78230129
65Selenocompound metabolism_Homo sapiens_hsa004500.77835694
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76537636
67Folate biosynthesis_Homo sapiens_hsa007900.74017220
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73630383
69Chemical carcinogenesis_Homo sapiens_hsa052040.73393340
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72485444
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69985734
72Other glycan degradation_Homo sapiens_hsa005110.67933134
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67830917
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67612610
75Huntingtons disease_Homo sapiens_hsa050160.67592256
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65349604
77Caffeine metabolism_Homo sapiens_hsa002320.65236339
78Biosynthesis of amino acids_Homo sapiens_hsa012300.64685092
79Cardiac muscle contraction_Homo sapiens_hsa042600.62969984
80Propanoate metabolism_Homo sapiens_hsa006400.62219817
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.59669009
82Antigen processing and presentation_Homo sapiens_hsa046120.56201251
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55801628
84Sulfur relay system_Homo sapiens_hsa041220.51943169
85Thyroid cancer_Homo sapiens_hsa052160.46521532
86Peroxisome_Homo sapiens_hsa041460.46507398
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.42633597
88Fatty acid metabolism_Homo sapiens_hsa012120.40633183
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.40224921
90Thyroid hormone synthesis_Homo sapiens_hsa049180.40198131
91ABC transporters_Homo sapiens_hsa020100.38584564
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38519524
93Metabolic pathways_Homo sapiens_hsa011000.38381036
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36364101
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35423079
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.34857766
97Bladder cancer_Homo sapiens_hsa052190.34393065
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34325413
99Retinol metabolism_Homo sapiens_hsa008300.34231791
100Leishmaniasis_Homo sapiens_hsa051400.34223748
101Salmonella infection_Homo sapiens_hsa051320.34170523
102Fatty acid elongation_Homo sapiens_hsa000620.32335227
103Insulin resistance_Homo sapiens_hsa049310.30930862
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29662478
105Gastric acid secretion_Homo sapiens_hsa049710.27451325
106Cocaine addiction_Homo sapiens_hsa050300.26733769
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.23351516
108Pertussis_Homo sapiens_hsa051330.22586170
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21701724
110Insulin secretion_Homo sapiens_hsa049110.21585964
111African trypanosomiasis_Homo sapiens_hsa051430.20618540
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20406801
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20363663
114Salivary secretion_Homo sapiens_hsa049700.20326805
115Viral myocarditis_Homo sapiens_hsa054160.16530559
116Complement and coagulation cascades_Homo sapiens_hsa046100.15914290
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.14948586
118N-Glycan biosynthesis_Homo sapiens_hsa005100.14409599
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14014646
120Toxoplasmosis_Homo sapiens_hsa051450.13338148
121Fatty acid biosynthesis_Homo sapiens_hsa000610.12797788
122Amoebiasis_Homo sapiens_hsa051460.11910370
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.11835804
124Renin secretion_Homo sapiens_hsa049240.11606102
125Hematopoietic cell lineage_Homo sapiens_hsa046400.10874441
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.10692070
127VEGF signaling pathway_Homo sapiens_hsa043700.10604659
128Lysosome_Homo sapiens_hsa041420.09906802
129Rheumatoid arthritis_Homo sapiens_hsa053230.09501255
130GnRH signaling pathway_Homo sapiens_hsa049120.08949580
131Influenza A_Homo sapiens_hsa051640.07689944
132Amphetamine addiction_Homo sapiens_hsa050310.06625161

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