TFG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.13322340
2Golgi transport vesicle coating (GO:0048200)6.13322340
3signal peptide processing (GO:0006465)5.26487627
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.69110783
5cullin deneddylation (GO:0010388)4.47054090
6purine nucleobase biosynthetic process (GO:0009113)4.45621361
7protein retention in ER lumen (GO:0006621)4.43790936
8protein deneddylation (GO:0000338)4.32818275
9nucleobase biosynthetic process (GO:0046112)4.11459210
10L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.96465971
11COPII vesicle coating (GO:0048208)3.93048282
12formation of translation preinitiation complex (GO:0001731)3.87235466
13DNA deamination (GO:0045006)3.77962236
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75093383
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.65015083
16proteasome assembly (GO:0043248)3.59708622
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53212775
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45136201
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.40456612
20regulation of cellular amino acid metabolic process (GO:0006521)3.36207439
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32459285
22negative regulation of ligase activity (GO:0051352)3.32459285
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.32306464
24positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29158571
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27578009
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27578009
27antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.27474947
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25118285
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25118285
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25118285
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20251120
32polyketide metabolic process (GO:0030638)3.19691498
33doxorubicin metabolic process (GO:0044598)3.19691498
34daunorubicin metabolic process (GO:0044597)3.19691498
35DNA replication checkpoint (GO:0000076)3.15580601
36positive regulation of ligase activity (GO:0051351)3.15240050
37amino acid salvage (GO:0043102)3.15172715
38L-methionine salvage (GO:0071267)3.15172715
39L-methionine biosynthetic process (GO:0071265)3.15172715
40establishment of integrated proviral latency (GO:0075713)3.14346657
41nucleotide-sugar biosynthetic process (GO:0009226)3.14115456
42antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.13264431
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11505556
44signal transduction involved in DNA damage checkpoint (GO:0072422)3.11505556
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.08558317
46cholesterol biosynthetic process (GO:0006695)3.01133777
47L-serine metabolic process (GO:0006563)3.00754252
48GDP-mannose metabolic process (GO:0019673)2.98908637
49UDP-N-acetylglucosamine metabolic process (GO:0006047)2.96934127
50nucleobase-containing small molecule interconversion (GO:0015949)2.94956612
51establishment of viral latency (GO:0019043)2.93907334
522-deoxyribonucleotide biosynthetic process (GO:0009265)2.93215604
53deoxyribose phosphate biosynthetic process (GO:0046385)2.93215604
54aminoglycoside antibiotic metabolic process (GO:0030647)2.92250975
55telomere maintenance via semi-conservative replication (GO:0032201)2.89843109
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.85416363
57histone-serine phosphorylation (GO:0035404)2.84551615
58oxidative phosphorylation (GO:0006119)2.83494245
59DNA strand elongation involved in DNA replication (GO:0006271)2.82613821
60IMP biosynthetic process (GO:0006188)2.80939231
61telomere maintenance via recombination (GO:0000722)2.80645013
62positive regulation of cell cycle arrest (GO:0071158)2.80521681
63desmosome organization (GO:0002934)2.79849056
644-hydroxyproline metabolic process (GO:0019471)2.79437883
65cell cycle G1/S phase transition (GO:0044843)2.79144640
66G1/S transition of mitotic cell cycle (GO:0000082)2.79144640
67deoxyribonucleotide biosynthetic process (GO:0009263)2.78607021
68sterol biosynthetic process (GO:0016126)2.77389082
69cell adhesion mediated by integrin (GO:0033627)2.76468546
70regulation of ubiquitin-protein transferase activity (GO:0051438)2.75942676
71ribosome biogenesis (GO:0042254)2.75325347
72mitotic metaphase plate congression (GO:0007080)2.74192902
73purine-containing compound salvage (GO:0043101)2.71904841
74protein maturation by protein folding (GO:0022417)2.71705761
75tRNA aminoacylation for protein translation (GO:0006418)2.71663434
76viral mRNA export from host cell nucleus (GO:0046784)2.68038246
77DNA strand elongation (GO:0022616)2.67486275
78regulation of ligase activity (GO:0051340)2.66635248
79folic acid-containing compound biosynthetic process (GO:0009396)2.63039346
80de novo protein folding (GO:0006458)2.59643580
81tricarboxylic acid cycle (GO:0006099)2.59421734
82positive regulation of mitochondrial fission (GO:0090141)2.58832237
83amino acid activation (GO:0043038)2.58737090
84tRNA aminoacylation (GO:0043039)2.58737090
85proline biosynthetic process (GO:0006561)2.56277674
86DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.53946890
87metallo-sulfur cluster assembly (GO:0031163)2.53869825
88iron-sulfur cluster assembly (GO:0016226)2.53869825
89type B pancreatic cell proliferation (GO:0044342)2.52800288
90tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52731447
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52731447
927-methylguanosine mRNA capping (GO:0006370)2.52051147
93regulation of translation in response to stress (GO:0043555)2.51899781
94peptide catabolic process (GO:0043171)2.51495336
95nuclear envelope reassembly (GO:0031468)2.51461238
96mitotic nuclear envelope reassembly (GO:0007084)2.51461238
97de novo posttranslational protein folding (GO:0051084)2.51072590
98membrane budding (GO:0006900)2.49658012
99mitotic nuclear envelope disassembly (GO:0007077)2.49269504
100ribosome assembly (GO:0042255)2.47975439
101methionine biosynthetic process (GO:0009086)2.47594202
102RNA capping (GO:0036260)2.45937422
1037-methylguanosine RNA capping (GO:0009452)2.45937422
104mitotic recombination (GO:0006312)2.44409408
105peptidyl-proline hydroxylation (GO:0019511)2.44074710
106regulation of spindle organization (GO:0090224)2.43904203
107regulation of mitotic spindle organization (GO:0060236)2.43681581
108lipopolysaccharide biosynthetic process (GO:0009103)2.43630163
109intestinal cholesterol absorption (GO:0030299)2.43403491
110metaphase plate congression (GO:0051310)2.43375600
111nucleoside diphosphate biosynthetic process (GO:0009133)2.42592798
112vesicle coating (GO:0006901)2.41474004
113regulation of cardioblast differentiation (GO:0051890)2.41285346
114purine nucleotide salvage (GO:0032261)2.41124474
115pteridine-containing compound biosynthetic process (GO:0042559)2.40452108
116negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.40246421
117protein hydroxylation (GO:0018126)2.38154847
118nucleoside salvage (GO:0043174)2.37277136
119erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37275488
120L-phenylalanine metabolic process (GO:0006558)2.37275488
121positive regulation of actin filament depolymerization (GO:0030836)2.36706561
122positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.36590825
123sequestering of metal ion (GO:0051238)2.35614667
124regulation of cell cycle arrest (GO:0071156)2.35345461
125endosome to pigment granule transport (GO:0043485)2.35256510
126endosome to melanosome transport (GO:0035646)2.35256510
127dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.32299240
128ER overload response (GO:0006983)2.31915851
129IMP metabolic process (GO:0046040)2.31433060
130nucleotide-sugar metabolic process (GO:0009225)2.31388479
131branched-chain amino acid catabolic process (GO:0009083)2.30595940
132gluconeogenesis (GO:0006094)2.27142543
133skin morphogenesis (GO:0043589)2.26354919
134ER to Golgi vesicle-mediated transport (GO:0006888)2.25797781
135regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.25249097
136bundle of His cell to Purkinje myocyte communication (GO:0086069)2.21716595
137NADPH regeneration (GO:0006740)2.19124867
138pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.18955382
139ventricular cardiac muscle cell development (GO:0055015)2.18186218
140glycolytic process (GO:0006096)2.15821703
141serine family amino acid biosynthetic process (GO:0009070)2.15024090
142glycoside metabolic process (GO:0016137)2.14250871
143isoprenoid biosynthetic process (GO:0008299)2.11727390
144protein N-linked glycosylation via asparagine (GO:0018279)2.11380584
145fatty acid elongation (GO:0030497)2.10990213
146response to redox state (GO:0051775)2.09675650
147peptidyl-asparagine modification (GO:0018196)2.09401949
148terpenoid biosynthetic process (GO:0016114)2.08802876
149hexose biosynthetic process (GO:0019319)2.08802063
150regulation of cellular amine metabolic process (GO:0033238)2.08617886
151cell redox homeostasis (GO:0045454)2.06092496
152retinal metabolic process (GO:0042574)2.05234372
153quinone metabolic process (GO:1901661)2.04667866
154ribonucleoprotein complex disassembly (GO:0032988)2.04153220
155protein N-linked glycosylation (GO:0006487)2.03210685
156protein heterotetramerization (GO:0051290)2.02540893
157regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.01865022
158hemidesmosome assembly (GO:0031581)2.01636984
159cellular aldehyde metabolic process (GO:0006081)2.01613969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.21988561
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00360201
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78019730
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.68370275
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.45561685
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.30043275
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13453507
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.12183632
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.88145669
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64771289
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54616744
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.53268512
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51471726
14ZNF263_19887448_ChIP-Seq_K562_Human2.49859589
15* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49293945
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48154577
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41691007
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.39226255
19* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.38931016
20AR_21909140_ChIP-Seq_LNCAP_Human2.30180432
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29427660
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28855557
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18257371
24VDR_23849224_ChIP-Seq_CD4+_Human2.17517948
25DCP1A_22483619_ChIP-Seq_HELA_Human2.16307564
26* GABP_19822575_ChIP-Seq_HepG2_Human2.16031586
27XRN2_22483619_ChIP-Seq_HELA_Human2.11483698
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07805455
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.06541738
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.06405833
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.02055482
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99944515
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98549929
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96881837
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94932289
36* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94251862
37* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.93546156
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88519671
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.84995980
40* ELK1_19687146_ChIP-ChIP_HELA_Human1.83437937
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80393950
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80118896
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77223490
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73864180
45FOXP3_21729870_ChIP-Seq_TREG_Human1.69717415
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66955770
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63063643
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59095693
49TFEB_21752829_ChIP-Seq_HELA_Human1.58609695
50* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58461014
51TTF2_22483619_ChIP-Seq_HELA_Human1.52484151
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.51673926
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50873060
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46980297
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45307117
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.44412204
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.39890714
58KDM5A_27292631_Chip-Seq_BREAST_Human1.39869205
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39606104
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39103676
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.38189883
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37706602
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36027208
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35705541
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.35552869
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.33242727
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31907584
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30864430
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29917511
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29862837
71TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.29756203
72EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29009736
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28961989
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28952129
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26946674
76* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22693835
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22347640
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21208778
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21208778
80EOMES_21245162_ChIP-Seq_HESCs_Human1.18341890
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18139835
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17704320
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17651656
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17569627
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17089437
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13492193
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12734024
88TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10459363
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09736722
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09365731
91TRIM28_21343339_ChIP-Seq_HEK293_Human1.08768333
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08460397
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08193042
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06130228
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05428642
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05397847
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04839190
98CLOCK_20551151_ChIP-Seq_293T_Human1.04734196
99CIITA_25753668_ChIP-Seq_RAJI_Human1.04634376
100SOX17_20123909_ChIP-Seq_XEN_Mouse1.03883954
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02803188
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02762604
103ATF3_27146783_Chip-Seq_COLON_Human1.01151309
104ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00302112
105* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99395657
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99189782
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99172121
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98183079
109* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97539972
110* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96658257
111SOX2_20726797_ChIP-Seq_SW620_Human0.96477011
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95877010
113* SPI1_23547873_ChIP-Seq_NB4_Human0.95683354
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.95598209
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95533126
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95157968
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.94443666
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94333161
119TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93054919
120IRF8_21731497_ChIP-ChIP_J774_Mouse0.92820338
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92743319
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.92559460
123* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92279803
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91214341
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90872758
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90739331
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90649060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.96121993
2MP0008438_abnormal_cutaneous_collagen3.14796672
3MP0004957_abnormal_blastocyst_morpholog3.05169870
4MP0006054_spinal_hemorrhage3.02242917
5MP0005503_abnormal_tendon_morphology2.58783629
6MP0010234_abnormal_vibrissa_follicle2.42102511
7MP0008007_abnormal_cellular_replicative2.39697163
8MP0003806_abnormal_nucleotide_metabolis2.33999889
9MP0003123_paternal_imprinting2.32254647
10MP0003186_abnormal_redox_activity2.24144630
11MP0009697_abnormal_copulation2.10807110
12MP0003077_abnormal_cell_cycle2.08469414
13MP0005084_abnormal_gallbladder_morpholo2.05376419
14MP0005623_abnormal_meninges_morphology1.96734018
15MP0008932_abnormal_embryonic_tissue1.95240335
16MP0010094_abnormal_chromosome_stability1.90170051
17MP0010352_gastrointestinal_tract_polyps1.83093163
18MP0002139_abnormal_hepatobiliary_system1.82648065
19MP0003705_abnormal_hypodermis_morpholog1.80702678
20MP0001666_abnormal_nutrient_absorption1.72327044
21MP0001529_abnormal_vocalization1.71283562
22MP0010030_abnormal_orbit_morphology1.71222411
23MP0000762_abnormal_tongue_morphology1.66245950
24MP0008789_abnormal_olfactory_epithelium1.65547258
25MP0005220_abnormal_exocrine_pancreas1.61206007
26MP0003111_abnormal_nucleus_morphology1.54203810
27MP0009053_abnormal_anal_canal1.52622147
28MP0004264_abnormal_extraembryonic_tissu1.50226057
29MP0005501_abnormal_skin_physiology1.49776086
30MP0010368_abnormal_lymphatic_system1.49628289
31MP0003656_abnormal_erythrocyte_physiolo1.47455001
32MP0003221_abnormal_cardiomyocyte_apopto1.46082179
33MP0002234_abnormal_pharynx_morphology1.43188658
34MP0003943_abnormal_hepatobiliary_system1.42226144
35MP0008058_abnormal_DNA_repair1.41066667
36MP0001730_embryonic_growth_arrest1.40011368
37MP0002233_abnormal_nose_morphology1.39147728
38MP0003122_maternal_imprinting1.37781099
39MP0005085_abnormal_gallbladder_physiolo1.37322212
40MP0005275_abnormal_skin_tensile1.36751292
41MP0005257_abnormal_intraocular_pressure1.34772727
42MP0005499_abnormal_olfactory_system1.34019762
43MP0005394_taste/olfaction_phenotype1.34019762
44MP0003950_abnormal_plasma_membrane1.33916050
45MP0000579_abnormal_nail_morphology1.31939251
46MP0009333_abnormal_splenocyte_physiolog1.31608987
47MP0000647_abnormal_sebaceous_gland1.28831988
48MP0005360_urolithiasis1.25558893
49MP0003755_abnormal_palate_morphology1.23332473
50MP0002796_impaired_skin_barrier1.22611617
51MP0003937_abnormal_limbs/digits/tail_de1.21351220
52MP0000537_abnormal_urethra_morphology1.19883098
53MP0000350_abnormal_cell_proliferation1.19855467
54MP0009840_abnormal_foam_cell1.16392212
55MP0003941_abnormal_skin_development1.13324237
56MP0001697_abnormal_embryo_size1.13248399
57MP0002938_white_spotting1.11250389
58MP0000467_abnormal_esophagus_morphology1.10571221
59MP0004233_abnormal_muscle_weight1.10154022
60MP0003315_abnormal_perineum_morphology1.10057244
61MP0005197_abnormal_uvea_morphology1.09988119
62MP0010678_abnormal_skin_adnexa1.09819620
63MP0003984_embryonic_growth_retardation1.09416221
64MP0004134_abnormal_chest_morphology1.08795313
65MP0000751_myopathy1.06046406
66MP0002697_abnormal_eye_size1.05364116
67MP0000013_abnormal_adipose_tissue1.04101464
68MP0004197_abnormal_fetal_growth/weight/1.04098250
69MP0002088_abnormal_embryonic_growth/wei1.03271146
70MP0009384_cardiac_valve_regurgitation1.03142685
71MP0001542_abnormal_bone_strength1.02568154
72MP0005023_abnormal_wound_healing1.02503923
73MP0002090_abnormal_vision1.02491730
74MP0002084_abnormal_developmental_patter1.01745180
75MP0000490_abnormal_crypts_of1.01395881
76MP0008875_abnormal_xenobiotic_pharmacok1.01158786
77MP0001727_abnormal_embryo_implantation1.00494860
78MP0001764_abnormal_homeostasis1.00330871
79MP0001293_anophthalmia0.99434387
80MP0002080_prenatal_lethality0.99268824
81MP0005380_embryogenesis_phenotype0.98687346
82MP0001672_abnormal_embryogenesis/_devel0.98687346
83MP0004782_abnormal_surfactant_physiolog0.98588541
84MP0003195_calcinosis0.98581452
85MP0003279_aneurysm0.97536869
86MP0002098_abnormal_vibrissa_morphology0.97497548
87MP0000358_abnormal_cell_content/0.97309814
88MP0005365_abnormal_bile_salt0.96951609
89MP0003385_abnormal_body_wall0.96947765
90MP0001299_abnormal_eye_distance/0.96790978
91MP0003942_abnormal_urinary_system0.96697838
92MP0005508_abnormal_skeleton_morphology0.96595086
93MP0005083_abnormal_biliary_tract0.96337134
94MP0000049_abnormal_middle_ear0.95997382
95MP0000003_abnormal_adipose_tissue0.95637781
96MP0002877_abnormal_melanocyte_morpholog0.95338710
97MP0003890_abnormal_embryonic-extraembry0.94764889
98MP0003786_premature_aging0.94304549
99MP0009672_abnormal_birth_weight0.92357409
100MP0005390_skeleton_phenotype0.91595859
101MP0008260_abnormal_autophagy0.91241877
102MP0004272_abnormal_basement_membrane0.89711476
103MP0009250_abnormal_appendicular_skeleto0.89697652
104MP0001533_abnormal_skeleton_physiology0.88146644
105MP0004858_abnormal_nervous_system0.87796613
106MP0001216_abnormal_epidermal_layer0.87488478
107MP0005187_abnormal_penis_morphology0.87074444
108MP0009780_abnormal_chondrocyte_physiolo0.86719904
109MP0005248_abnormal_Harderian_gland0.84541797
110MP0004808_abnormal_hematopoietic_stem0.84535658
111MP0003183_abnormal_peptide_metabolism0.84161564
112MP0000313_abnormal_cell_death0.83864842
113MP0005332_abnormal_amino_acid0.83771596
114MP0002282_abnormal_trachea_morphology0.83454313
115MP0000462_abnormal_digestive_system0.83340672
116MP0002933_joint_inflammation0.81893745
117MP0002295_abnormal_pulmonary_circulatio0.81884305
118MP0010771_integument_phenotype0.81357312
119MP0003868_abnormal_feces_composition0.81242741
120MP0003566_abnormal_cell_adhesion0.80831057
121MP0005058_abnormal_lysosome_morphology0.80694348
122MP0002086_abnormal_extraembryonic_tissu0.80287417
123MP0000598_abnormal_liver_morphology0.80187425
124MP0003567_abnormal_fetal_cardiomyocyte0.79329022
125MP0003283_abnormal_digestive_organ0.79314209
126MP0004084_abnormal_cardiac_muscle0.78579630
127MP0002148_abnormal_hypersensitivity_rea0.78282416
128MP0005408_hypopigmentation0.77112763
129MP0002396_abnormal_hematopoietic_system0.76796037
130MP0001944_abnormal_pancreas_morphology0.76195927
131MP0008057_abnormal_DNA_replication0.75241338
132MP0002113_abnormal_skeleton_development0.74416608
133MP0002085_abnormal_embryonic_tissue0.74218267
134MP0001243_abnormal_dermal_layer0.74189046
135MP0006036_abnormal_mitochondrial_physio0.74096473
136MP0002060_abnormal_skin_morphology0.73561259
137MP0005319_abnormal_enzyme/_coenzyme0.73168516
138MP0000749_muscle_degeneration0.71199683
139MP0000372_irregular_coat_pigmentation0.70883459
140MP0003795_abnormal_bone_structure0.70757760
141MP0003436_decreased_susceptibility_to0.70582503
142MP0000163_abnormal_cartilage_morphology0.70309598
143MP0003718_maternal_effect0.69954109
144MP0010307_abnormal_tumor_latency0.69475855
145MP0001835_abnormal_antigen_presentation0.68260167
146MP0009785_altered_susceptibility_to0.67954005
147MP0002115_abnormal_skeleton_extremities0.66813547
148MP0003121_genomic_imprinting0.66335886
149MP0000678_abnormal_parathyroid_gland0.66322012
150MP0001915_intracranial_hemorrhage0.66019841

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)3.68406101
2Beaking of vertebral bodies (HP:0004568)3.63744464
3Protrusio acetabuli (HP:0003179)3.43871395
4Vertebral compression fractures (HP:0002953)3.39073455
5Cholecystitis (HP:0001082)3.16113648
6Abnormal gallbladder physiology (HP:0012438)3.16113648
7Cervical subluxation (HP:0003308)3.11196318
8Biconcave vertebral bodies (HP:0004586)3.04433968
9Premature rupture of membranes (HP:0001788)2.96215407
10Cupped ribs (HP:0000887)2.93955916
11Poor head control (HP:0002421)2.92451787
12Hand muscle atrophy (HP:0009130)2.71046596
13Nonimmune hydrops fetalis (HP:0001790)2.67794500
14Type I transferrin isoform profile (HP:0003642)2.65750471
15Reduced antithrombin III activity (HP:0001976)2.63871648
16Microretrognathia (HP:0000308)2.59946266
17Hyperglycinemia (HP:0002154)2.50895305
18Abnormal protein glycosylation (HP:0012346)2.48292130
19Abnormal glycosylation (HP:0012345)2.48292130
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.48292130
21Abnormal protein N-linked glycosylation (HP:0012347)2.48292130
22Abnormal pancreas size (HP:0012094)2.46915724
23Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45514737
24Shoulder girdle muscle weakness (HP:0003547)2.44454280
25Nausea (HP:0002018)2.40974823
26Intrahepatic cholestasis (HP:0001406)2.39925305
27Distal upper limb amyotrophy (HP:0007149)2.39153547
28Upper limb amyotrophy (HP:0009129)2.39153547
29Trismus (HP:0000211)2.38184701
30Neoplasm of the adrenal gland (HP:0100631)2.36369908
31Hypobetalipoproteinemia (HP:0003563)2.34946987
32Upper limb muscle weakness (HP:0003484)2.30853298
33Pterygium (HP:0001059)2.29246647
34Hepatic necrosis (HP:0002605)2.28512482
35Carpal bone hypoplasia (HP:0001498)2.27643425
36Soft skin (HP:0000977)2.25901777
37Microglossia (HP:0000171)2.25333395
38Hypokinesia (HP:0002375)2.25293350
39Abnormality of dentin (HP:0010299)2.23708605
40Atrophic scars (HP:0001075)2.22435128
41Cerebral hypomyelination (HP:0006808)2.21865161
42* Degeneration of anterior horn cells (HP:0002398)2.20948288
43* Abnormality of the anterior horn cell (HP:0006802)2.20948288
44Hypoglycemic coma (HP:0001325)2.20376674
45Abnormality of the distal phalanges of the toes (HP:0010182)2.18728084
46Aplastic anemia (HP:0001915)2.17821875
47Generalized aminoaciduria (HP:0002909)2.17471452
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16848282
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16848282
50Delayed epiphyseal ossification (HP:0002663)2.15871436
51Follicular hyperkeratosis (HP:0007502)2.15362162
52Right ventricular cardiomyopathy (HP:0011663)2.13925457
53Broad face (HP:0000283)2.13413023
54Diastasis recti (HP:0001540)2.12414666
55Autoamputation (HP:0001218)2.09025109
56Flat capital femoral epiphysis (HP:0003370)2.07869642
57Short nail (HP:0001799)2.07754916
58Thoracolumbar scoliosis (HP:0002944)2.07744156
59Abnormality of the acetabulum (HP:0003170)2.07160985
60Breech presentation (HP:0001623)2.06500309
61Abnormal tarsal ossification (HP:0008369)2.05393064
62Cerebral edema (HP:0002181)2.05025762
63Hypoplastic pelvis (HP:0008839)2.04226598
64Acute encephalopathy (HP:0006846)2.02848197
65Esophageal neoplasm (HP:0100751)2.02671232
66Neoplasm of head and neck (HP:0012288)2.02671232
67Cortical dysplasia (HP:0002539)2.01617505
68Glossoptosis (HP:0000162)1.99129175
69Insidious onset (HP:0003587)1.98423070
70Termporal pattern (HP:0011008)1.98423070
71Vitreoretinal degeneration (HP:0000655)1.97708224
72Neuroendocrine neoplasm (HP:0100634)1.96607447
73Birth length less than 3rd percentile (HP:0003561)1.96189438
74Patent foramen ovale (HP:0001655)1.96119750
75Rough bone trabeculation (HP:0100670)1.95795162
76Irregular vertebral endplates (HP:0003301)1.95532092
77Platyspondyly (HP:0000926)1.93141065
78Sparse eyelashes (HP:0000653)1.91480768
79Multiple enchondromatosis (HP:0005701)1.89913073
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88471166
81Abnormality of alanine metabolism (HP:0010916)1.88471166
82Hyperalaninemia (HP:0003348)1.88471166
83Abnormality of glycine metabolism (HP:0010895)1.87164289
84Abnormality of serine family amino acid metabolism (HP:0010894)1.87164289
85Conjugated hyperbilirubinemia (HP:0002908)1.86293146
86Flared iliac wings (HP:0002869)1.85840820
87Abnormality of the umbilical cord (HP:0010881)1.85489113
88Slender long bone (HP:0003100)1.84256734
89Neonatal short-limb short stature (HP:0008921)1.83750942
90Selective tooth agenesis (HP:0001592)1.83581783
91Acute necrotizing encephalopathy (HP:0006965)1.82893090
92Abnormality of the intrinsic pathway (HP:0010989)1.81234634
93Hepatocellular necrosis (HP:0001404)1.80848373
94Entropion (HP:0000621)1.80530497
95Hypoplasia of the pons (HP:0012110)1.80036856
96Pheochromocytoma (HP:0002666)1.79738830
97Epiphyseal dysplasia (HP:0002656)1.78568087
98Abnormality of the musculature of the pelvis (HP:0001469)1.77893650
99Abnormality of the hip-girdle musculature (HP:0001445)1.77893650
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77804415
101Absent epiphyses (HP:0010577)1.77804415
102Coxa vara (HP:0002812)1.77729915
103Ankle contracture (HP:0006466)1.77713071
104Increased serum pyruvate (HP:0003542)1.76479622
105Abnormality of glycolysis (HP:0004366)1.76479622
106Abnormal mitochondria in muscle tissue (HP:0008316)1.76320408
107Bifid tongue (HP:0010297)1.75771018
108Genu varum (HP:0002970)1.75556174
109Abnormality of the calcaneus (HP:0008364)1.75232532
110Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.73132409
111Abnormality of femoral epiphyses (HP:0006499)1.73132409
112Stenosis of the external auditory canal (HP:0000402)1.73085022
113Abnormalities of placenta or umbilical cord (HP:0001194)1.72503443
114Hyperglycemia (HP:0003074)1.71332570
115Proximal placement of thumb (HP:0009623)1.71248782
116Ileus (HP:0002595)1.70932535
11711 pairs of ribs (HP:0000878)1.70859362
118Abnormality of the pons (HP:0007361)1.70194433
119Microvesicular hepatic steatosis (HP:0001414)1.70092990
120Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69600018
121Palpitations (HP:0001962)1.69424862
122Vertebral hypoplasia (HP:0008417)1.68914503
123Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.68914503
124Proximal tubulopathy (HP:0000114)1.68458513
125Hypoglycemic seizures (HP:0002173)1.67962208
126Abnormality of the femoral head (HP:0003368)1.67393150
127Adrenal hypoplasia (HP:0000835)1.67327144
128Deviation of the thumb (HP:0009603)1.66944371
129Secondary amenorrhea (HP:0000869)1.66185861
130Increased serum lactate (HP:0002151)1.65639441
131Abnormality of the vertebral endplates (HP:0005106)1.65603189
132Abnormality of the epiphysis of the femoral head (HP:0010574)1.65165303
133Opisthotonus (HP:0002179)1.64125980
134Hydroureter (HP:0000072)1.63923176
135Abnormality of the aortic arch (HP:0012303)1.62344600
136Autoimmune thrombocytopenia (HP:0001973)1.62112239
137Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.61942306
138Abnormality of the proximal phalanges of the hand (HP:0009834)1.61354068
139Calcaneovalgus deformity (HP:0001848)1.61264326
140Gout (HP:0001997)1.60937532
141Popliteal pterygium (HP:0009756)1.60800318
142Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.60532365
143Abnormality of the heme biosynthetic pathway (HP:0010472)1.59367743
144Abnormality of the fetal cardiovascular system (HP:0010948)1.59306475
145Abnormal umbilical cord blood vessels (HP:0011403)1.59306475
146Single umbilical artery (HP:0001195)1.59306475
147Abnormal trabecular bone morphology (HP:0100671)1.58858453
148Abnormality of serum amino acid levels (HP:0003112)1.57893630
149Abnormal delivery (HP:0001787)1.57344768
150Onycholysis (HP:0001806)1.57036735
151Alopecia of scalp (HP:0002293)1.54041272
152Median cleft lip (HP:0000161)1.53938194
153Pelvic girdle muscle weakness (HP:0003749)1.53760155
154Fragile nails (HP:0001808)1.50805284
155Limb-girdle muscle weakness (HP:0003325)1.50498599
156Hypoplastic left heart (HP:0004383)1.50025173
157Abnormality of methionine metabolism (HP:0010901)1.49771115
158Prominent metopic ridge (HP:0005487)1.49610755
159Postnatal microcephaly (HP:0005484)1.49320150
160Unilateral renal agenesis (HP:0000122)1.48943596
161Hypoplasia of the uterus (HP:0000013)1.47374661
162Myoglobinuria (HP:0002913)1.47236162
163Fat malabsorption (HP:0002630)1.47023678
164Hyperglycinuria (HP:0003108)1.46885405
165Hyperammonemia (HP:0001987)1.46729556
166Abnormality of the labia (HP:0000058)1.46623353
167Abnormality of the Achilles tendon (HP:0005109)1.45477377
168Bifid uvula (HP:0000193)1.44922021
169Limb-girdle muscle atrophy (HP:0003797)1.43888128
170Hydroxyprolinuria (HP:0003080)1.42170407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.89868850
2BUB13.28015824
3BRSK23.19951635
4EIF2AK33.11165538
5TRIM282.60982236
6TESK12.60885617
7MST1R2.52746473
8WEE12.43741722
9ERBB32.16200765
10LIMK12.14535259
11PIM22.10275697
12MET2.03436942
13ACVR1B1.95613688
14ERN11.87119860
15FLT31.86098492
16PASK1.83060890
17RPS6KA41.82194886
18BCKDK1.77823283
19PLK41.74899331
20SCYL21.72772019
21TESK21.71391548
22PBK1.71148909
23STK38L1.67513791
24BRSK11.64126746
25STK161.61886680
26NME21.56109208
27NEK91.54443408
28CDC71.52676428
29PLK31.51050160
30VRK21.45116562
31LMTK21.44246850
32MST41.42516934
33ZAK1.40027573
34CSNK1G31.38276414
35ERBB41.38165936
36CSNK1A1L1.35017327
37NEK21.34021668
38AKT31.30891918
39MKNK11.27959736
40PDK21.22573055
41STK241.19868209
42EPHB21.19153066
43CSNK1G11.17602430
44IRAK31.13738056
45NEK11.12491377
46MAP4K21.09282990
47TSSK61.09175956
48MAP2K71.09134586
49PLK11.06366549
50EIF2AK21.06209198
51CDK81.05357860
52SIK31.02473682
53NTRK10.98584346
54MAP3K110.98309683
55KDR0.97830282
56STK30.97018554
57ZAP700.95600572
58EPHA20.95438192
59BRAF0.94303661
60MAPKAPK30.93970423
61SRPK10.93163467
62ARAF0.91689858
63YES10.91435931
64BCR0.91234758
65ATR0.88176485
66PDGFRA0.88169325
67CDK70.88138035
68AURKB0.88064806
69PKN20.88058226
70CSNK1G20.87625381
71MYLK0.87130658
72TTK0.85651546
73MAP3K30.83014892
74NME10.78219075
75FRK0.77085018
76EPHA30.76933645
77DYRK20.75926944
78PRKG20.72309493
79LATS10.68970884
80DYRK30.68099773
81VRK10.68009164
82NUAK10.67173540
83PLK20.64157152
84AURKA0.63755557
85TGFBR10.63090746
86DAPK10.62856458
87JAK30.62537728
88MOS0.62531536
89MAP3K90.62085957
90PIK3CA0.61359683
91TYK20.60550374
92TBK10.59924201
93MAP3K50.59299188
94CSNK2A10.59187785
95CDK90.57981953
96CDK140.57298269
97MAP3K80.57257753
98PAK40.54965934
99ILK0.53856205
100DYRK1B0.53381581
101DDR20.52949621
102PAK10.51978560
103MAPKAPK20.51670099
104CDK180.50832023
105CAMK2G0.50458859
106AKT20.50317564
107DMPK0.50297972
108PRKCI0.48680237
109RPS6KB20.48426705
110KSR10.48123717
111RAF10.47075978
112LATS20.46790277
113PAK20.45419432
114CHUK0.45204177
115EPHB10.45134214
116NLK0.44882376
117TRPM70.44254688
118PIM10.43164589
119FGFR10.43022972
120PTK20.42194327
121MKNK20.41523591
122MAP3K140.41428933
123STK40.41277371
124MAP3K20.40590489
125CDK150.40188055
126CDK11A0.40169241
127CAMK2D0.39720917
128OBSCN0.39443587
129MINK10.39438216
130FER0.39365443
131CHEK20.38926023
132ROCK20.38630584
133RPS6KB10.38590127
134CCNB10.38416480
135PRKCE0.38325953
136STK390.37540425
137ABL20.35135366
138MAP3K120.34851332
139BMPR20.34004712
140STK100.33951715
141CHEK10.33709236
142DAPK30.33572853

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.30626470
2Protein export_Homo sapiens_hsa030603.86752361
3DNA replication_Homo sapiens_hsa030303.13132240
4Fatty acid elongation_Homo sapiens_hsa000622.55832274
5RNA polymerase_Homo sapiens_hsa030202.37051251
6Folate biosynthesis_Homo sapiens_hsa007902.34157703
7Mismatch repair_Homo sapiens_hsa034302.30401315
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26069127
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22488783
10Pyrimidine metabolism_Homo sapiens_hsa002402.13441749
11RNA transport_Homo sapiens_hsa030132.10173251
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03853533
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02790214
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.96475419
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95261238
16Base excision repair_Homo sapiens_hsa034101.94354465
17Cell cycle_Homo sapiens_hsa041101.90828805
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.81334823
19Spliceosome_Homo sapiens_hsa030401.80835889
20Legionellosis_Homo sapiens_hsa051341.73309145
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70235629
22Homologous recombination_Homo sapiens_hsa034401.62813888
23Propanoate metabolism_Homo sapiens_hsa006401.57820598
24Nucleotide excision repair_Homo sapiens_hsa034201.55871064
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52754833
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51855560
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51524502
28One carbon pool by folate_Homo sapiens_hsa006701.45088881
29Galactose metabolism_Homo sapiens_hsa000521.42520007
30Sulfur metabolism_Homo sapiens_hsa009201.41705695
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36960647
32Basal transcription factors_Homo sapiens_hsa030221.27901483
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.26015760
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25976947
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19510344
36Selenocompound metabolism_Homo sapiens_hsa004501.19419493
37Fat digestion and absorption_Homo sapiens_hsa049751.16845463
38p53 signaling pathway_Homo sapiens_hsa041151.16055475
39Ribosome_Homo sapiens_hsa030101.15792353
40Glutathione metabolism_Homo sapiens_hsa004801.15616912
41RNA degradation_Homo sapiens_hsa030181.15291086
42Renin-angiotensin system_Homo sapiens_hsa046141.13825924
43Fatty acid metabolism_Homo sapiens_hsa012121.12667740
44Purine metabolism_Homo sapiens_hsa002301.11242683
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10256818
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.08553507
47Phenylalanine metabolism_Homo sapiens_hsa003601.05356470
48N-Glycan biosynthesis_Homo sapiens_hsa005101.05091315
49Herpes simplex infection_Homo sapiens_hsa051681.03611315
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02651494
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02119556
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01070677
53Carbon metabolism_Homo sapiens_hsa012001.00580888
54Arginine biosynthesis_Homo sapiens_hsa002201.00422860
55Sulfur relay system_Homo sapiens_hsa041220.99059118
56Epstein-Barr virus infection_Homo sapiens_hsa051690.96465283
57Caffeine metabolism_Homo sapiens_hsa002320.95256587
58Parkinsons disease_Homo sapiens_hsa050120.94663450
59Starch and sucrose metabolism_Homo sapiens_hsa005000.91921748
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.90335815
61Non-homologous end-joining_Homo sapiens_hsa034500.89800349
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.89046034
63Pentose phosphate pathway_Homo sapiens_hsa000300.88216061
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87289553
65Vitamin digestion and absorption_Homo sapiens_hsa049770.87112877
66Butanoate metabolism_Homo sapiens_hsa006500.84235243
67Biosynthesis of amino acids_Homo sapiens_hsa012300.83304333
68Antigen processing and presentation_Homo sapiens_hsa046120.82995774
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82027058
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81466586
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.80448087
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79759899
73Protein digestion and absorption_Homo sapiens_hsa049740.79571719
74Chemical carcinogenesis_Homo sapiens_hsa052040.78692094
75Retinol metabolism_Homo sapiens_hsa008300.78084618
76Fatty acid degradation_Homo sapiens_hsa000710.77773443
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75818874
78Vibrio cholerae infection_Homo sapiens_hsa051100.75575401
79Tyrosine metabolism_Homo sapiens_hsa003500.72165451
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71911361
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70850994
82Fructose and mannose metabolism_Homo sapiens_hsa000510.69042766
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.67971951
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67559507
85Huntingtons disease_Homo sapiens_hsa050160.67279453
86mRNA surveillance pathway_Homo sapiens_hsa030150.67180280
87Oxidative phosphorylation_Homo sapiens_hsa001900.66614350
88Adherens junction_Homo sapiens_hsa045200.62833654
89Regulation of autophagy_Homo sapiens_hsa041400.62618152
90beta-Alanine metabolism_Homo sapiens_hsa004100.61746378
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60325201
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60231824
93Pyruvate metabolism_Homo sapiens_hsa006200.59771059
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59140531
95Influenza A_Homo sapiens_hsa051640.57937972
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55967904
97Vitamin B6 metabolism_Homo sapiens_hsa007500.54070350
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53839232
99Sphingolipid metabolism_Homo sapiens_hsa006000.52528480
100Arginine and proline metabolism_Homo sapiens_hsa003300.51265212
101Viral carcinogenesis_Homo sapiens_hsa052030.51232634
102Steroid biosynthesis_Homo sapiens_hsa001000.51226800
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.51215552
104Shigellosis_Homo sapiens_hsa051310.51020828
105ECM-receptor interaction_Homo sapiens_hsa045120.50443665
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49109917
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48302081
108Metabolic pathways_Homo sapiens_hsa011000.45888188
109Apoptosis_Homo sapiens_hsa042100.44264251
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44031280
111Lysosome_Homo sapiens_hsa041420.43502748
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43446038
113Measles_Homo sapiens_hsa051620.43381935
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43351463
115Tight junction_Homo sapiens_hsa045300.43317390
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42721533
117Circadian rhythm_Homo sapiens_hsa047100.40910180
118Phagosome_Homo sapiens_hsa041450.40825166
119Oocyte meiosis_Homo sapiens_hsa041140.40078302
120* Thyroid cancer_Homo sapiens_hsa052160.38347036
121Complement and coagulation cascades_Homo sapiens_hsa046100.37813328
122Arachidonic acid metabolism_Homo sapiens_hsa005900.37579927
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37471655
124Type I diabetes mellitus_Homo sapiens_hsa049400.36573232
125Bladder cancer_Homo sapiens_hsa052190.36400849
126Hippo signaling pathway_Homo sapiens_hsa043900.36259197
127Peroxisome_Homo sapiens_hsa041460.35976326
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33968813
129TGF-beta signaling pathway_Homo sapiens_hsa043500.33659870
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31880580
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29163367
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28546735
133Fanconi anemia pathway_Homo sapiens_hsa034600.27873943
134Asthma_Homo sapiens_hsa053100.26225281
135Pertussis_Homo sapiens_hsa051330.26087948
136Allograft rejection_Homo sapiens_hsa053300.25823092

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