ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	otic vesicle formation (GO:0030916)	4.94591169
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.84163083
3	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.64906860
4	sulfation (GO:0051923)	4.60622653
5	regulation of autophagic vacuole assembly (GO:2000785)	4.56907298
6	presynaptic membrane organization (GO:0097090)	4.49162892
7	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.39666046
8	activation of protein kinase B activity (GO:0032148)	4.35086302
9	neuron cell-cell adhesion (GO:0007158)	4.30689654
10	DNA double-strand break processing (GO:0000729)	4.29778895
11	regulation of oxidative phosphorylation (GO:0002082)	4.22678072
12	coenzyme catabolic process (GO:0009109)	4.14048961
13	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.93545772
14	chaperone-mediated protein transport (GO:0072321)	3.84350751
15	protein complex biogenesis (GO:0070271)	3.77821012
16	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	3.70293370
17	positive regulation of protein homodimerization activity (GO:0090073)	3.69535677
18	positive regulation of catecholamine secretion (GO:0033605)	3.69335376
19	nucleobase catabolic process (GO:0046113)	3.68219587
20	glycosphingolipid biosynthetic process (GO:0006688)	3.63462890
21	DNA integration (GO:0015074)	3.61167662
22	regulation of vacuole organization (GO:0044088)	3.49908330
23	locomotory exploration behavior (GO:0035641)	3.48656382
24	cGMP-mediated signaling (GO:0019934)	3.44785584
25	peroxisome fission (GO:0016559)	3.41358786
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.36818929
27	relaxation of smooth muscle (GO:0044557)	3.36577040
28	dermatan sulfate biosynthetic process (GO:0030208)	3.34367256
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.29932242
30	NADH dehydrogenase complex assembly (GO:0010257)	3.29932242
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.29932242
32	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.29516049
33	L-methionine salvage (GO:0071267)	3.23287085
34	L-methionine biosynthetic process (GO:0071265)	3.23287085
35	amino acid salvage (GO:0043102)	3.23287085
36	enteric nervous system development (GO:0048484)	3.14606441
37	platelet dense granule organization (GO:0060155)	3.14279191
38	gamma-aminobutyric acid transport (GO:0015812)	3.14189224
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.12864178
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.12836619
41	mRNA cleavage (GO:0006379)	3.12505774
42	retinal cone cell development (GO:0046549)	3.11557265
43	tongue development (GO:0043586)	3.11281674
44	regulation of oxidative stress-induced neuron death (GO:1903203)	3.10869074
45	replication fork processing (GO:0031297)	3.06570403
46	adaptation of signaling pathway (GO:0023058)	2.92868791
47	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.91364173
48	negative regulation of T-helper cell differentiation (GO:0045623)	2.91364173
49	negative regulation of striated muscle cell apoptotic process (GO:0010664)	2.84855709
50	dermatan sulfate metabolic process (GO:0030205)	2.81207806
51	regulation of phospholipase A2 activity (GO:0032429)	2.80836845
52	dopamine transport (GO:0015872)	2.80326386
53	dicarboxylic acid catabolic process (GO:0043649)	2.79529009
54	epithelial cell differentiation involved in kidney development (GO:0035850)	2.76964323
55	regulation of feeding behavior (GO:0060259)	2.72397983
56	sperm motility (GO:0030317)	2.69897112
57	protein localization to cell surface (GO:0034394)	2.68341202
58	ADP metabolic process (GO:0046031)	2.68245856
59	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.60174935
60	limb bud formation (GO:0060174)	2.59831778
61	presynaptic membrane assembly (GO:0097105)	2.58830350
62	mesenchymal-epithelial cell signaling (GO:0060638)	2.58685634
63	positive regulation of amine transport (GO:0051954)	2.56686944
64	negative regulation of DNA binding (GO:0043392)	2.55708295
65	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.55638092
66	regulation of female receptivity (GO:0045924)	2.54914231
67	water-soluble vitamin biosynthetic process (GO:0042364)	2.54747118
68	response to misfolded protein (GO:0051788)	2.53775077
69	protein neddylation (GO:0045116)	2.51966577
70	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.51041365
71	synaptic transmission, glutamatergic (GO:0035249)	2.50496093
72	growth hormone secretion (GO:0030252)	2.49512067
73	regulation of coenzyme metabolic process (GO:0051196)	2.48103086
74	regulation of cofactor metabolic process (GO:0051193)	2.48103086
75	inositol phosphate catabolic process (GO:0071545)	2.47617227
76	indole-containing compound catabolic process (GO:0042436)	2.46127734
77	indolalkylamine catabolic process (GO:0046218)	2.46127734
78	tryptophan catabolic process (GO:0006569)	2.46127734
79	androgen biosynthetic process (GO:0006702)	2.44972709
80	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.44934350
81	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.44452956
82	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.44249665
83	nucleoside diphosphate phosphorylation (GO:0006165)	2.44190773
84	embryonic digestive tract morphogenesis (GO:0048557)	2.44054270
85	diacylglycerol metabolic process (GO:0046339)	2.43752378
86	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.43013935
87	ATP synthesis coupled proton transport (GO:0015986)	2.43013935
88	acrosome reaction (GO:0007340)	2.42675866
89	axon ensheathment in central nervous system (GO:0032291)	2.41306371
90	central nervous system myelination (GO:0022010)	2.41306371
91	potassium ion export (GO:0071435)	2.39908902
92	urinary tract smooth muscle contraction (GO:0014848)	2.38440021
93	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.38374979
94	regulation of cilium movement (GO:0003352)	2.38276924
95	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.37199510
96	ventricular system development (GO:0021591)	2.35894120
97	muscle fiber development (GO:0048747)	2.33497612
98	positive regulation of mitochondrial fission (GO:0090141)	2.32973461
99	multicellular organism reproduction (GO:0032504)	2.31982764
100	behavioral response to cocaine (GO:0048148)	2.31735695

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.79811219
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.59713665
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.02565587
4	GBX2_23144817_ChIP-Seq_PC3_Human	4.58252892
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.85793740
6	VDR_22108803_ChIP-Seq_LS180_Human	3.49222882
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.90946571
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.78045099
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41080757
10	P300_19829295_ChIP-Seq_ESCs_Human	2.17400348
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14890744
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04475289
13	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.03964215
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03862782
15	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.02062347
16	FUS_26573619_Chip-Seq_HEK293_Human	1.99908875
17	EZH2_22144423_ChIP-Seq_EOC_Human	1.96584880
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91475215
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.86988381
20	EWS_26573619_Chip-Seq_HEK293_Human	1.83832274
21	AR_21572438_ChIP-Seq_LNCaP_Human	1.83527687
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.83116695
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.80123322
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70796368
25	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.68006889
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64097399
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.64097399
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60075587
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52670317
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.52610370
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.50113437
32	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.50098253
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.49089390
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47939027
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46197087
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45759656
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.40283687
38	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38210164
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37463016
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37463016
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32424776
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28366006
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.28088558
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21514514
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21160219
46	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.12839143
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12734829
48	RXR_22108803_ChIP-Seq_LS180_Human	1.12002198
49	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11687657
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10170582
51	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.09283564
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09221123
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08964025
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07769675
55	AR_25329375_ChIP-Seq_VCAP_Human	1.06765251
56	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.05361838
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.05182687
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04931797
59	NCOR_22424771_ChIP-Seq_293T_Human	1.02018890
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99628210
61	TCF4_23295773_ChIP-Seq_U87_Human	0.99278395
62	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.99229994
63	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.99021243
64	SOX9_26525672_Chip-Seq_HEART_Mouse	0.98411196
65	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97275644
66	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.96627743
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95889871
68	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95467550
69	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93065094
70	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93065094
71	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.92888772
72	STAT3_23295773_ChIP-Seq_U87_Human	0.92186231
73	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.91125783
74	FOXP3_21729870_ChIP-Seq_TREG_Human	0.91066230
75	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.89540712
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.89459578
77	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.89351983
78	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.88833677
79	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.87972368
80	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.87668060
81	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.87269039
82	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.86800839
83	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86685050
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.86345109
85	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.85919667
86	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.85610510
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.85019438
88	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.84785039
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.84516628
90	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.84258175
91	REST_21632747_ChIP-Seq_MESCs_Mouse	0.84178019
92	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.83961029
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.83768862
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.82570711
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.82462400
96	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.82085362
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.81653704
98	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.80779316
99	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.80715711
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.80251804

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.19355590
2	MP0005084_abnormal_gallbladder_morpholo	3.64102973
3	MP0001529_abnormal_vocalization	2.94560884
4	MP0009697_abnormal_copulation	2.80817497
5	MP0001984_abnormal_olfaction	2.74836041
6	MP0001968_abnormal_touch/_nociception	2.67010472
7	MP0008004_abnormal_stomach_pH	2.66563692
8	MP0002736_abnormal_nociception_after	2.62843495
9	MP0010368_abnormal_lymphatic_system	2.52953144
10	MP0002102_abnormal_ear_morphology	2.49271133
11	MP0003806_abnormal_nucleotide_metabolis	2.44833866
12	MP0002735_abnormal_chemical_nociception	2.21378600
13	MP0009046_muscle_twitch	2.11319558
14	MP0002132_abnormal_respiratory_system	2.09889238
15	MP0004859_abnormal_synaptic_plasticity	2.07716361
16	MP0006292_abnormal_olfactory_placode	2.03409603
17	MP0005167_abnormal_blood-brain_barrier	2.02263789
18	MP0005253_abnormal_eye_physiology	2.01677961
19	MP0005410_abnormal_fertilization	1.96778410
20	MP0004084_abnormal_cardiac_muscle	1.95844111
21	MP0000749_muscle_degeneration	1.89323810
22	MP0005646_abnormal_pituitary_gland	1.85834216
23	MP0006072_abnormal_retinal_apoptosis	1.77709712
24	MP0005499_abnormal_olfactory_system	1.74724951
25	MP0005394_taste/olfaction_phenotype	1.74724951
26	MP0000465_gastrointestinal_hemorrhage	1.72865773
27	MP0002837_dystrophic_cardiac_calcinosis	1.68720099
28	MP0001905_abnormal_dopamine_level	1.66419614
29	MP0001486_abnormal_startle_reflex	1.61167737
30	MP0002653_abnormal_ependyma_morphology	1.60033038
31	MP0005171_absent_coat_pigmentation	1.57615392
32	MP0006276_abnormal_autonomic_nervous	1.52463594
33	MP0002272_abnormal_nervous_system	1.51436035
34	MP0000049_abnormal_middle_ear	1.50435360
35	MP0001986_abnormal_taste_sensitivity	1.48811054
36	MP0003315_abnormal_perineum_morphology	1.48737383
37	MP0009250_abnormal_appendicular_skeleto	1.46626409
38	MP0003385_abnormal_body_wall	1.38679964
39	MP0004272_abnormal_basement_membrane	1.37921153
40	MP0003635_abnormal_synaptic_transmissio	1.34229086
41	MP0009745_abnormal_behavioral_response	1.32391868
42	MP0008789_abnormal_olfactory_epithelium	1.27850233
43	MP0002160_abnormal_reproductive_system	1.26794372
44	MP0002249_abnormal_larynx_morphology	1.23701933
45	MP0005551_abnormal_eye_electrophysiolog	1.21441458
46	MP0002233_abnormal_nose_morphology	1.21146504
47	MP0010386_abnormal_urinary_bladder	1.20188588
48	MP0002127_abnormal_cardiovascular_syste	1.19129291
49	MP0003880_abnormal_central_pattern	1.16760641
50	MP0005391_vision/eye_phenotype	1.16526917
51	MP0002751_abnormal_autonomic_nervous	1.15947547
52	MP0000631_abnormal_neuroendocrine_gland	1.15757336
53	MP0001188_hyperpigmentation	1.13938227
54	MP0002108_abnormal_muscle_morphology	1.13600715
55	MP0004036_abnormal_muscle_relaxation	1.12570440
56	MP0001270_distended_abdomen	1.12230414
57	MP0002064_seizures	1.12085135
58	MP0002572_abnormal_emotion/affect_behav	1.11097610
59	MP0003567_abnormal_fetal_cardiomyocyte	1.10661212
60	MP0003186_abnormal_redox_activity	1.08965602
61	MP0001501_abnormal_sleep_pattern	1.08926725
62	MP0002295_abnormal_pulmonary_circulatio	1.06241684
63	MP0006036_abnormal_mitochondrial_physio	1.06002718
64	MP0003938_abnormal_ear_development	1.04569558
65	MP0002277_abnormal_respiratory_mucosa	1.02960718
66	MP0008775_abnormal_heart_ventricle	1.02599952
67	MP0001970_abnormal_pain_threshold	1.01713464
68	MP0002067_abnormal_sensory_capabilities	1.00963011
69	MP0004215_abnormal_myocardial_fiber	0.99455995
70	MP0001764_abnormal_homeostasis	0.99188047
71	MP0009780_abnormal_chondrocyte_physiolo	0.96791364
72	MP0002752_abnormal_somatic_nervous	0.95079920
73	MP0001299_abnormal_eye_distance/	0.94793266
74	MP0004885_abnormal_endolymph	0.94459748
75	MP0006035_abnormal_mitochondrial_morpho	0.93936501
76	MP0002063_abnormal_learning/memory/cond	0.90565985
77	MP0005423_abnormal_somatic_nervous	0.89247432
78	MP0000230_abnormal_systemic_arterial	0.87531142
79	MP0005187_abnormal_penis_morphology	0.86360743
80	MP0004085_abnormal_heartbeat	0.85864186
81	MP0002733_abnormal_thermal_nociception	0.85421771
82	MP0001963_abnormal_hearing_physiology	0.84554695
83	MP0003935_abnormal_craniofacial_develop	0.84354092
84	MP0005620_abnormal_muscle_contractility	0.83791247
85	MP0003755_abnormal_palate_morphology	0.82522965
86	MP0004484_altered_response_of	0.81674900
87	MP0004133_heterotaxia	0.81667459
88	MP0003698_abnormal_male_reproductive	0.81428362
89	MP0002115_abnormal_skeleton_extremities	0.79422238
90	MP0002090_abnormal_vision	0.79132749
91	MP0001544_abnormal_cardiovascular_syste	0.78849927
92	MP0005385_cardiovascular_system_phenoty	0.78849927
93	MP0005248_abnormal_Harderian_gland	0.76414278
94	MP0002282_abnormal_trachea_morphology	0.76056952
95	MP0002734_abnormal_mechanical_nocicepti	0.73153995
96	MP0001879_abnormal_lymphatic_vessel	0.72717923
97	MP0003119_abnormal_digestive_system	0.72499343
98	MP0008995_early_reproductive_senescence	0.72020240
99	MP0005083_abnormal_biliary_tract	0.72007421
100	MP0004270_analgesia	0.71300429

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Vitreoretinal degeneration (HP:0000655)	4.23007805
2	Abnormal hair whorl (HP:0010721)	3.87439311
3	Pendular nystagmus (HP:0012043)	3.44533816
4	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.26734935
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.26734935
6	Abnormality of the columella (HP:0009929)	3.24083094
7	Anterior segment dysgenesis (HP:0007700)	3.06421111
8	Reduced antithrombin III activity (HP:0001976)	2.98601635
9	Dyschromatopsia (HP:0007641)	2.91978222
10	Increased corneal curvature (HP:0100692)	2.90544773
11	Keratoconus (HP:0000563)	2.90544773
12	Rimmed vacuoles (HP:0003805)	2.87188687
13	Atonic seizures (HP:0010819)	2.84708029
14	Patchy hypopigmentation of hair (HP:0011365)	2.82382994
15	Decreased central vision (HP:0007663)	2.78766430
16	Abnormal mitochondria in muscle tissue (HP:0008316)	2.76350987
17	Resting tremor (HP:0002322)	2.74973352
18	Retinal dysplasia (HP:0007973)	2.71262754
19	True hermaphroditism (HP:0010459)	2.70143680
20	Clumsiness (HP:0002312)	2.67061013
21	Poor head control (HP:0002421)	2.62731459
22	Focal motor seizures (HP:0011153)	2.61503590
23	Abolished electroretinogram (ERG) (HP:0000550)	2.59436940
24	Occipital encephalocele (HP:0002085)	2.57581868
25	Unsteady gait (HP:0002317)	2.54575118
26	White forelock (HP:0002211)	2.51211145
27	Disproportionate short-trunk short stature (HP:0003521)	2.50298615
28	Aplasia involving bones of the upper limbs (HP:0009823)	2.46513258
29	Aplasia of the phalanges of the hand (HP:0009802)	2.46513258
30	Aplasia involving bones of the extremities (HP:0009825)	2.46513258
31	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.41806365
32	Abnormal protein N-linked glycosylation (HP:0012347)	2.41806365
33	Abnormal protein glycosylation (HP:0012346)	2.41806365
34	Abnormal glycosylation (HP:0012345)	2.41806365
35	Acute necrotizing encephalopathy (HP:0006965)	2.41109064
36	Mitochondrial inheritance (HP:0001427)	2.39092803
37	Neoplasm of the oral cavity (HP:0100649)	2.38742514
38	Methylmalonic acidemia (HP:0002912)	2.38601353
39	Hypoglycemic seizures (HP:0002173)	2.35697959
40	Abnormality of endocrine pancreas physiology (HP:0012093)	2.32543735
41	Abnormality of the pancreatic islet cells (HP:0006476)	2.32543735
42	Postural instability (HP:0002172)	2.29428538
43	Focal seizures (HP:0007359)	2.28660459
44	Intestinal atresia (HP:0011100)	2.26190476
45	Pancreatic cysts (HP:0001737)	2.25525189
46	Protruding tongue (HP:0010808)	2.23815215
47	Pancreatic fibrosis (HP:0100732)	2.20503188
48	Pancreatic islet-cell hyperplasia (HP:0004510)	2.19928782
49	Methylmalonic aciduria (HP:0012120)	2.16623183
50	Septo-optic dysplasia (HP:0100842)	2.15259328
51	Optic nerve hypoplasia (HP:0000609)	2.14973367
52	Hyperglycinemia (HP:0002154)	2.14358649
53	Progressive macrocephaly (HP:0004481)	2.14098686
54	Poor eye contact (HP:0000817)	2.10377381
55	Exercise-induced muscle cramps (HP:0003710)	2.06291300
56	Weak cry (HP:0001612)	2.04834397
57	Growth hormone deficiency (HP:0000824)	2.04173054
58	Medial flaring of the eyebrow (HP:0010747)	2.04093616
59	Male pseudohermaphroditism (HP:0000037)	2.03747769
60	Congenital primary aphakia (HP:0007707)	2.03303374
61	Hepatoblastoma (HP:0002884)	2.03150170
62	Gait imbalance (HP:0002141)	2.02747806
63	Pili torti (HP:0003777)	2.01964805
64	Abnormality of the lumbar spine (HP:0100712)	2.01077407
65	Chorioretinal atrophy (HP:0000533)	1.99232884
66	Esotropia (HP:0000565)	1.98305029
67	Abnormality of the shoulder girdle musculature (HP:0001435)	1.97793905
68	Inability to walk (HP:0002540)	1.97405793
69	Hypothermia (HP:0002045)	1.96462750
70	Type I transferrin isoform profile (HP:0003642)	1.95525944
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91931915
72	Cerebral hypomyelination (HP:0006808)	1.91261488
73	Retinal atrophy (HP:0001105)	1.89671644
74	Absent speech (HP:0001344)	1.88843926
75	Hepatocellular necrosis (HP:0001404)	1.87957846
76	Progressive cerebellar ataxia (HP:0002073)	1.87924203
77	Chronic hepatic failure (HP:0100626)	1.85156731
78	Facial diplegia (HP:0001349)	1.84501358
79	Recurrent corneal erosions (HP:0000495)	1.83255309
80	Cupped ear (HP:0000378)	1.82750121
81	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.82185680
82	Abnormality of serum amino acid levels (HP:0003112)	1.81410760
83	Abnormality of the calf musculature (HP:0001430)	1.80388730
84	Proximal amyotrophy (HP:0007126)	1.79345088
85	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.79112812
86	Thyroid-stimulating hormone excess (HP:0002925)	1.78979533
87	Sensorimotor neuropathy (HP:0007141)	1.78590295
88	Increased intramyocellular lipid droplets (HP:0012240)	1.78473762
89	Muscle hypertrophy of the lower extremities (HP:0008968)	1.76109009
90	Nephrogenic diabetes insipidus (HP:0009806)	1.76104443
91	Eosinophilia (HP:0001880)	1.75534572
92	Hyperinsulinemic hypoglycemia (HP:0000825)	1.73883088
93	Large for gestational age (HP:0001520)	1.73586417
94	Ketosis (HP:0001946)	1.72934410
95	Ventricular fibrillation (HP:0001663)	1.72871277
96	Abnormality of vitamin B metabolism (HP:0004340)	1.72363854
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.71440280
98	Abnormality of the intrinsic pathway (HP:0010989)	1.71393404
99	Postnatal microcephaly (HP:0005484)	1.71218127
100	Vaginal atresia (HP:0000148)	1.71137079

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.13125991
2	EPHA4	3.49787092
3	BMPR1B	3.22653018
4	INSRR	2.94429097
5	LATS1	2.90321524
6	MAP2K7	2.48904185
7	MYLK	2.46866028
8	CSNK1A1L	2.37648139
9	CSNK1G3	2.36951372
10	TNIK	2.36439844
11	DYRK2	2.28751851
12	CSNK1G1	2.28686704
13	FRK	2.20818003
14	CSNK1G2	2.06657920
15	STK38L	2.03006602
16	ADRBK2	1.97873963
17	OBSCN	1.90489596
18	MARK3	1.87854704
19	DYRK3	1.66157665
20	GRK1	1.65166584
21	CCNB1	1.61771255
22	PTK2B	1.56749609
23	GRK5	1.56114122
24	NLK	1.34556686
25	IRAK2	1.32771483
26	NME1	1.26650446
27	NEK2	1.23429581
28	MAP3K5	1.22860851
29	TIE1	1.21150238
30	VRK2	1.18785734
31	STK16	1.09428919
32	LATS2	1.01599581
33	CDK3	0.97616065
34	MAP4K2	0.96878310
35	VRK1	0.94622654
36	SGK494	0.93978715
37	SGK223	0.93978715
38	MAP3K4	0.93600201
39	FLT3	0.90907927
40	MAP3K12	0.88159282
41	CDK8	0.86747317
42	PIK3CG	0.81332427
43	EPHA3	0.81057952
44	MAPK7	0.79608521
45	MARK1	0.76976943
46	AKT2	0.76973660
47	CDK19	0.75608537
48	RET	0.75207782
49	TLK1	0.75020780
50	FES	0.74997596
51	DAPK1	0.74899583
52	MAPK13	0.73889223
53	WNK3	0.73874915
54	ROCK1	0.73828048
55	TAF1	0.72074778
56	ACVR1B	0.71997981
57	NTRK2	0.70897022
58	PRKCG	0.70702780
59	ADRBK1	0.70391248
60	RPS6KA5	0.67540434
61	TNK2	0.66542778
62	GRK6	0.66030718
63	RPS6KB1	0.66019619
64	NUAK1	0.65577258
65	PLK2	0.63671474
66	DAPK3	0.63560593
67	MELK	0.62920683
68	PRKCQ	0.60821578
69	SRPK1	0.60124490
70	FGFR2	0.59369824
71	PKN1	0.58608256
72	PRKG2	0.55783849
73	MAPK12	0.54959268
74	MAP3K1	0.54527827
75	PRKCE	0.53365849
76	CSNK1A1	0.53344598
77	MKNK2	0.52222642
78	TGFBR1	0.51933354
79	SGK2	0.50707178
80	BCR	0.42447766
81	MAPK15	0.41974884
82	PLK1	0.40045602
83	PDK2	0.39901308
84	MINK1	0.39233718
85	PAK1	0.38210022
86	CSNK1D	0.38160450
87	MAP2K4	0.37523080
88	CASK	0.37308416
89	MKNK1	0.36729612
90	PRKG1	0.36363357
91	CAMK1	0.35125629
92	NME2	0.35066097
93	IRAK1	0.34562763
94	CAMK2D	0.33736692
95	BTK	0.31366484
96	CLK1	0.31251453
97	KDR	0.29668445
98	CDK5	0.29625901
99	CAMK2A	0.29188891
100	PRKACA	0.28882173

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.14378316
2	Parkinsons disease_Homo sapiens_hsa05012	3.09753063
3	Olfactory transduction_Homo sapiens_hsa04740	2.64349064
4	Sulfur relay system_Homo sapiens_hsa04122	2.58543857
5	Butanoate metabolism_Homo sapiens_hsa00650	2.21797743
6	Phototransduction_Homo sapiens_hsa04744	2.17916043
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.17781117
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.98444566
9	Nicotine addiction_Homo sapiens_hsa05033	1.93960670
10	Collecting duct acid secretion_Homo sapiens_hsa04966	1.77773940
11	Alzheimers disease_Homo sapiens_hsa05010	1.76431344
12	Chemical carcinogenesis_Homo sapiens_hsa05204	1.75365063
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.70658251
14	Circadian entrainment_Homo sapiens_hsa04713	1.68754013
15	Huntingtons disease_Homo sapiens_hsa05016	1.68508310
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62321685
17	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.59213221
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.58051753
19	Homologous recombination_Homo sapiens_hsa03440	1.53831571
20	GABAergic synapse_Homo sapiens_hsa04727	1.50302666
21	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.49655082
22	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.45474549
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.41305708
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.40173771
25	Gap junction_Homo sapiens_hsa04540	1.39132749
26	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.33534825
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32380436
28	RNA polymerase_Homo sapiens_hsa03020	1.32289484
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.32271248
30	RNA degradation_Homo sapiens_hsa03018	1.31255136
31	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.29707840
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.28382227
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.21831354
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.21022789
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.18677744
36	Calcium signaling pathway_Homo sapiens_hsa04020	1.18437408
37	Peroxisome_Homo sapiens_hsa04146	1.16798469
38	Salivary secretion_Homo sapiens_hsa04970	1.16541430
39	Basal transcription factors_Homo sapiens_hsa03022	1.16103590
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15574103
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15546508
42	Sphingolipid metabolism_Homo sapiens_hsa00600	1.13479281
43	Folate biosynthesis_Homo sapiens_hsa00790	1.12226896
44	Caffeine metabolism_Homo sapiens_hsa00232	1.11465319
45	Protein export_Homo sapiens_hsa03060	1.10831736
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06642342
47	Glutamatergic synapse_Homo sapiens_hsa04724	1.05005494
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.04971401
49	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.04898659
50	Renin secretion_Homo sapiens_hsa04924	1.04864784
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03732912
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99910828
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98805889
54	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.95681584
55	Spliceosome_Homo sapiens_hsa03040	0.92984932
56	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.91391986
57	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.88300786
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.87506824
59	Circadian rhythm_Homo sapiens_hsa04710	0.86153470
60	Taste transduction_Homo sapiens_hsa04742	0.82688974
61	Ribosome_Homo sapiens_hsa03010	0.80302895
62	Gastric acid secretion_Homo sapiens_hsa04971	0.78444284
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.78128921
64	Long-term depression_Homo sapiens_hsa04730	0.76039475
65	Retinol metabolism_Homo sapiens_hsa00830	0.75171675
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.75081492
67	Metabolic pathways_Homo sapiens_hsa01100	0.75057188
68	Purine metabolism_Homo sapiens_hsa00230	0.74799947
69	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.74347283
70	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.74124946
71	Propanoate metabolism_Homo sapiens_hsa00640	0.73216710
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.72372625
73	Platelet activation_Homo sapiens_hsa04611	0.71623150
74	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.71137539
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70887582
76	Glutathione metabolism_Homo sapiens_hsa00480	0.68260772
77	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.66755181
78	Serotonergic synapse_Homo sapiens_hsa04726	0.66430658
79	Alcoholism_Homo sapiens_hsa05034	0.66343178
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66083969
81	Morphine addiction_Homo sapiens_hsa05032	0.60744895
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.59798089
83	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59373344
84	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.55146426
85	PPAR signaling pathway_Homo sapiens_hsa03320	0.55100956
86	Regulation of autophagy_Homo sapiens_hsa04140	0.54319485
87	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.52524109
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51394252
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51364783
90	Amphetamine addiction_Homo sapiens_hsa05031	0.49689965
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.46954673
92	Arginine biosynthesis_Homo sapiens_hsa00220	0.46803831
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45741896
94	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43666088
95	Oocyte meiosis_Homo sapiens_hsa04114	0.43085422
96	Long-term potentiation_Homo sapiens_hsa04720	0.40713474
97	Cholinergic synapse_Homo sapiens_hsa04725	0.39383216
98	Vibrio cholerae infection_Homo sapiens_hsa05110	0.38983321
99	Proteasome_Homo sapiens_hsa03050	0.38249871
100	Phagosome_Homo sapiens_hsa04145	0.38134083

TFP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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