TFPT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.08321283
2maturation of SSU-rRNA (GO:0030490)4.91587887
3ribosome assembly (GO:0042255)4.82727215
4mitotic metaphase plate congression (GO:0007080)4.80930604
5purine nucleobase biosynthetic process (GO:0009113)4.76873609
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.59362154
7L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.43905937
8nucleobase biosynthetic process (GO:0046112)4.43304448
9NIK/NF-kappaB signaling (GO:0038061)4.38347987
10DNA strand elongation involved in DNA replication (GO:0006271)4.38190163
11ribosome biogenesis (GO:0042254)4.34080165
12formation of translation preinitiation complex (GO:0001731)4.22963523
13DNA strand elongation (GO:0022616)4.19386019
14DNA replication checkpoint (GO:0000076)4.07546186
15proteasome assembly (GO:0043248)4.02526814
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.02430176
17amino acid salvage (GO:0043102)4.02397999
18L-methionine salvage (GO:0071267)4.02397999
19L-methionine biosynthetic process (GO:0071265)4.02397999
20DNA replication initiation (GO:0006270)3.99427957
21Arp2/3 complex-mediated actin nucleation (GO:0034314)3.99385198
22GDP-mannose metabolic process (GO:0019673)3.96357428
23metaphase plate congression (GO:0051310)3.95578351
24protein maturation by protein folding (GO:0022417)3.93808574
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.90748579
26immunoglobulin mediated immune response (GO:0016064)3.89830147
27spliceosomal snRNP assembly (GO:0000387)3.87244021
28DNA replication-dependent nucleosome assembly (GO:0006335)3.85320183
29DNA replication-dependent nucleosome organization (GO:0034723)3.85320183
30telomere maintenance via semi-conservative replication (GO:0032201)3.85074252
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83991433
32regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76428140
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.75967027
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.75130192
35rRNA modification (GO:0000154)3.71162952
36spliceosomal complex assembly (GO:0000245)3.69700286
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.68780586
38termination of RNA polymerase III transcription (GO:0006386)3.68780586
39ribonucleoprotein complex biogenesis (GO:0022613)3.67362217
40purine deoxyribonucleotide catabolic process (GO:0009155)3.66797367
41amino sugar catabolic process (GO:0046348)3.62125272
42rRNA processing (GO:0006364)3.60872376
43ribosomal large subunit biogenesis (GO:0042273)3.50223517
44folic acid-containing compound biosynthetic process (GO:0009396)3.49549384
45ribosomal small subunit assembly (GO:0000028)3.49343151
46rRNA metabolic process (GO:0016072)3.47493670
47pseudouridine synthesis (GO:0001522)3.46611678
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.45458883
49negative regulation of ligase activity (GO:0051352)3.45458883
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41184017
51translational initiation (GO:0006413)3.39003110
52regulation of spindle organization (GO:0090224)3.38393089
53response to peptidoglycan (GO:0032494)3.36159350
54telomere maintenance via recombination (GO:0000722)3.35937210
55maturation of 5.8S rRNA (GO:0000460)3.34901853
56protein localization to kinetochore (GO:0034501)3.34258205
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.33809882
58methionine biosynthetic process (GO:0009086)3.32043785
59mitotic nuclear envelope disassembly (GO:0007077)3.30530616
60DNA replication-independent nucleosome organization (GO:0034724)3.30089981
61DNA replication-independent nucleosome assembly (GO:0006336)3.30089981
62mature B cell differentiation involved in immune response (GO:0002313)3.28952230
63protein K6-linked ubiquitination (GO:0085020)3.28808463
64positive thymic T cell selection (GO:0045059)3.27535604
65cytidine deamination (GO:0009972)3.26344369
66cytidine metabolic process (GO:0046087)3.26344369
67cytidine catabolic process (GO:0006216)3.26344369
68IMP biosynthetic process (GO:0006188)3.23689703
69positive regulation of ligase activity (GO:0051351)3.23666878
70folic acid metabolic process (GO:0046655)3.21105232
71establishment of chromosome localization (GO:0051303)3.20505296
72UV protection (GO:0009650)3.19291132
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18962102
74CENP-A containing nucleosome assembly (GO:0034080)3.18829464
75viral transcription (GO:0019083)3.15335117
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.15033915
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14882684
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14882684
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14882684
80negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.14202065
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13627261
82signal transduction involved in DNA damage checkpoint (GO:0072422)3.13627261
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13459552
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13459552
85pyrimidine-containing compound salvage (GO:0008655)3.13369456
86pyrimidine nucleoside salvage (GO:0043097)3.13369456
87methionine metabolic process (GO:0006555)3.11967869
88translational termination (GO:0006415)3.11026514
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.09024953
90mitotic recombination (GO:0006312)3.09023812
91adenosine receptor signaling pathway (GO:0001973)3.08955026
92actin nucleation (GO:0045010)3.08613816
93telomere maintenance via telomere lengthening (GO:0010833)3.08039285
947-methylguanosine mRNA capping (GO:0006370)3.07283664
95G1/S transition of mitotic cell cycle (GO:0000082)3.05921579
96cell cycle G1/S phase transition (GO:0044843)3.05921579
97chromatin remodeling at centromere (GO:0031055)3.05771382
98translational elongation (GO:0006414)3.04604032
99microtubule depolymerization (GO:0007019)3.04407502
100nuclear envelope disassembly (GO:0051081)3.04123364
101membrane disassembly (GO:0030397)3.04123364
102regulation of ubiquitin-protein transferase activity (GO:0051438)3.03887543
103RNA splicing, via transesterification reactions (GO:0000375)3.03406693
104negative regulation of chromosome segregation (GO:0051985)3.03349936
105transcription-coupled nucleotide-excision repair (GO:0006283)3.03039918
106deoxyribonucleotide catabolic process (GO:0009264)3.02420789
107B cell mediated immunity (GO:0019724)3.01694605
108regulation of cellular amino acid metabolic process (GO:0006521)3.00398370
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00268474
110negative regulation of sister chromatid segregation (GO:0033046)3.00268474
111negative regulation of mitotic sister chromatid separation (GO:2000816)3.00268474
112negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00268474
113RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.00109184
114mRNA splicing, via spliceosome (GO:0000398)3.00109184
115protein deneddylation (GO:0000338)2.99936332
116glycosphingolipid catabolic process (GO:0046479)2.98518424
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96417826
118mitotic spindle assembly checkpoint (GO:0007094)2.94217743
119negative regulation of myeloid cell apoptotic process (GO:0033033)2.93379305
120postreplication repair (GO:0006301)2.93244159
121histone exchange (GO:0043486)2.93101277
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.93054990
123protein localization to chromosome, centromeric region (GO:0071459)2.93014769
124protein complex localization (GO:0031503)2.91944273
125negative regulation of interleukin-12 production (GO:0032695)2.91804020
1267-methylguanosine RNA capping (GO:0009452)2.91256484
127RNA capping (GO:0036260)2.91256484
128positive regulation of monocyte chemotaxis (GO:0090026)2.90817130
129positive regulation of T cell apoptotic process (GO:0070234)2.90478580
130deoxyribose phosphate catabolic process (GO:0046386)2.89343903
131purine deoxyribonucleotide metabolic process (GO:0009151)2.85942884
132regulation of superoxide anion generation (GO:0032928)2.85647492
133pinocytosis (GO:0006907)2.85345973
134regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83895084
135deoxyribose phosphate biosynthetic process (GO:0046385)2.82530627
1362-deoxyribonucleotide biosynthetic process (GO:0009265)2.82530627
137antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82008678
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81733312
139metallo-sulfur cluster assembly (GO:0031163)2.80865676
140iron-sulfur cluster assembly (GO:0016226)2.80865676
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79200954
142G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.78374072
143positive regulation of lymphocyte apoptotic process (GO:0070230)2.78355614
144neutrophil activation involved in immune response (GO:0002283)2.75150483
145ribosomal small subunit biogenesis (GO:0042274)2.74417718
146response to interferon-beta (GO:0035456)2.70739807
147nucleotide salvage (GO:0043173)2.70651613
148cellular response to arsenic-containing substance (GO:0071243)2.70071820
149myeloid dendritic cell activation (GO:0001773)2.69644570
150lipopolysaccharide biosynthetic process (GO:0009103)2.69398795
151pyrimidine ribonucleoside catabolic process (GO:0046133)2.69119470
152T cell migration (GO:0072678)2.66248453
153myeloid dendritic cell differentiation (GO:0043011)2.66053706
154endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.65543844
155glycolipid catabolic process (GO:0019377)2.63205492
156barbed-end actin filament capping (GO:0051016)2.61612805
157activation of MAPKKK activity (GO:0000185)2.60013140
158lipopolysaccharide metabolic process (GO:0008653)2.59731077
159purine nucleotide salvage (GO:0032261)2.57453934
160modulation by symbiont of host cellular process (GO:0044068)2.55610757
161regulation of defense response to virus by virus (GO:0050690)2.55590308
1622-deoxyribonucleotide metabolic process (GO:0009394)2.54519590
163modulation by virus of host process (GO:0019054)2.54189502
164regulation of mitochondrial membrane potential (GO:0051881)2.54102636
165chaperone mediated protein folding requiring cofactor (GO:0051085)2.53757256
166regulation of lymphocyte migration (GO:2000401)2.53377758
167positive regulation of B cell differentiation (GO:0045579)2.52599016
168negative regulation of viral genome replication (GO:0045071)2.51556120
169nuclear envelope reassembly (GO:0031468)2.51281874
170mitotic nuclear envelope reassembly (GO:0007084)2.51281874
171regulation of release of cytochrome c from mitochondria (GO:0090199)2.50713511
172pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.49776238
173deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.48945705
174pentose metabolic process (GO:0019321)2.48850436
175monocyte chemotaxis (GO:0002548)2.46818504
176regulation of mononuclear cell migration (GO:0071675)2.46457663
177positive regulation of lymphocyte migration (GO:2000403)2.45892992
178type I interferon signaling pathway (GO:0060337)2.44982412
179cellular response to type I interferon (GO:0071357)2.44982412
180purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.44842267
181deoxyribose phosphate metabolic process (GO:0019692)2.44490840
182negative regulation of B cell apoptotic process (GO:0002903)2.42454390
183myeloid cell activation involved in immune response (GO:0002275)2.40721650
184granulocyte activation (GO:0036230)2.39140321
185response to type I interferon (GO:0034340)2.39087119
186deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.38140998
187tumor necrosis factor-mediated signaling pathway (GO:0033209)2.37780228
188lipoxygenase pathway (GO:0019372)2.37426993
189regulation of mast cell degranulation (GO:0043304)2.35055341
190modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34789785
191positive regulation by organism of defense response of other organism involved in symbiotic interact2.34789785
192modulation by symbiont of host immune response (GO:0052553)2.34789785
193positive regulation by symbiont of host defense response (GO:0052509)2.34789785
194modulation by symbiont of host defense response (GO:0052031)2.34789785
195modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34789785
196phagosome maturation (GO:0090382)2.32613405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72507502
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.06204687
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.99766040
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.35243211
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23712816
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.19963550
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.13398611
8* EST1_17652178_ChIP-ChIP_JURKAT_Human2.98831699
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98662289
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96310509
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90293578
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82316099
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80432158
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77325768
15* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77058330
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.76034716
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52871615
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46873580
19* XRN2_22483619_ChIP-Seq_HELA_Human2.46264440
20LXR_22292898_ChIP-Seq_THP-1_Human2.32656529
21* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31606318
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25848834
23* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21466133
24* VDR_23849224_ChIP-Seq_CD4+_Human2.20818581
25GABP_19822575_ChIP-Seq_HepG2_Human2.15946115
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12164483
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11794998
28* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04486706
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.98744615
30DCP1A_22483619_ChIP-Seq_HELA_Human1.95414823
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93194783
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91589802
33MYC_22102868_ChIP-Seq_BL_Human1.90899141
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.89355304
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.86304966
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85739509
37FOXP3_21729870_ChIP-Seq_TREG_Human1.84645340
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82418735
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.81164852
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80798451
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78911913
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78772093
43TTF2_22483619_ChIP-Seq_HELA_Human1.73987027
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73199588
45CIITA_25753668_ChIP-Seq_RAJI_Human1.72625794
46AR_21909140_ChIP-Seq_LNCAP_Human1.71280590
47VDR_24763502_ChIP-Seq_THP-1_Human1.70310416
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69672083
49MAF_26560356_Chip-Seq_TH2_Human1.69072312
50* SRF_21415370_ChIP-Seq_HL-1_Mouse1.68916767
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67782451
52* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66592099
53BCL6_27268052_Chip-Seq_Bcells_Human1.66489450
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.66118235
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65662886
56P68_20966046_ChIP-Seq_HELA_Human1.62677372
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62407691
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62196289
59MAF_26560356_Chip-Seq_TH1_Human1.61117251
60UTX_26944678_Chip-Seq_JUKART_Human1.59900734
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59204961
62KDM5A_27292631_Chip-Seq_BREAST_Human1.58743003
63* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57628377
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55935717
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55898667
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.55199345
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54816332
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53016054
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52182344
70BCOR_27268052_Chip-Seq_Bcells_Human1.50593244
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50375305
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49615176
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48921300
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48446879
75RACK7_27058665_Chip-Seq_MCF-7_Human1.48390291
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47232696
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46087938
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45642524
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42308198
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41961186
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40764855
82SPI1_23547873_ChIP-Seq_NB4_Human1.40505727
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36132918
84* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35369696
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34835810
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33643422
87* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33582554
88KDM2B_26808549_Chip-Seq_DND41_Human1.33336479
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32155136
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31934395
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31763794
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31625259
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.31336729
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.30653790
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29459490
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.28023393
97TFEB_21752829_ChIP-Seq_HELA_Human1.26077548
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23510712
99CTCF_26484167_Chip-Seq_Bcells_Mouse1.21902359
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21493023
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18171781
102IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17659620
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17638979
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17366702
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17103555
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16801726
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16775876
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16747836
109VDR_21846776_ChIP-Seq_THP-1_Human1.15839859
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15478084
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15264683
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14545405
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14126856
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13421100
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12228617
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12005240
117ELK1_19687146_ChIP-ChIP_HELA_Human1.11516315
118TCF7_22412390_ChIP-Seq_EML_Mouse1.11029759
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08900775
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08867220
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08413504
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08055040
123CTCF_21964334_Chip-Seq_Bcells_Human1.07839728
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07585246
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07457236
126ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07410645
127NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06674753
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.05752555
129SA1_27219007_Chip-Seq_Bcells_Human1.05635310
130PHF8_20622854_ChIP-Seq_HELA_Human1.05613984
131ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04964755
132GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04962792
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04830717
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04735874
135CTCF_20526341_ChIP-Seq_ESCs_Human1.04440015
136* E2F1_20622854_ChIP-Seq_HELA_Human1.04359315
137CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02665712
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02521958
139NOTCH1_21737748_ChIP-Seq_TLL_Human1.01836139
140KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00907324
141MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99368345
142ZNF263_19887448_ChIP-Seq_K562_Human0.99223050
143SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94667270
144* FOXP1_21924763_ChIP-Seq_HESCs_Human0.93007402
145* NANOG_21062744_ChIP-ChIP_HESCs_Human0.92969021
146PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90761860
147CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90004269
148TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88233146
149YY1_22570637_ChIP-Seq_MALME-3M_Human0.88082765
150MYC_18940864_ChIP-ChIP_HL60_Human0.87928569
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.87445562
152CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87347862
153TET1_21451524_ChIP-Seq_MESCs_Mouse0.86897010
154ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85792975
155* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85396138
156GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85187692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.53695416
2MP0005058_abnormal_lysosome_morphology4.86316597
3MP0003111_abnormal_nucleus_morphology4.76297983
4MP0004957_abnormal_blastocyst_morpholog4.57258212
5MP0003077_abnormal_cell_cycle4.03800274
6MP0010094_abnormal_chromosome_stability3.95257047
7MP0002653_abnormal_ependyma_morphology3.46066299
8MP0008058_abnormal_DNA_repair3.31162389
9MP0003436_decreased_susceptibility_to3.17496867
10MP0002148_abnormal_hypersensitivity_rea2.99582432
11MP0005671_abnormal_response_to2.88583902
12MP0008877_abnormal_DNA_methylation2.79350678
13MP0005000_abnormal_immune_tolerance2.70651418
14MP0009840_abnormal_foam_cell2.69828180
15MP0006082_CNS_inflammation2.67556616
16MP0003718_maternal_effect2.60238523
17MP0008932_abnormal_embryonic_tissue2.59281027
18MP0009785_altered_susceptibility_to2.55591110
19MP0001730_embryonic_growth_arrest2.52269249
20MP0005025_abnormal_response_to2.49645750
21MP0003075_altered_response_to2.49628319
22MP0008007_abnormal_cellular_replicative2.45783202
23MP0003123_paternal_imprinting2.35628172
24MP0002419_abnormal_innate_immunity2.32702900
25MP0001835_abnormal_antigen_presentation2.31783379
26MP0002877_abnormal_melanocyte_morpholog2.28020500
27MP0009333_abnormal_splenocyte_physiolog2.22454816
28MP0000350_abnormal_cell_proliferation2.18426440
29MP0004510_myositis2.14058924
30MP0008057_abnormal_DNA_replication2.13610972
31MP0003806_abnormal_nucleotide_metabolis2.11509915
32MP0002723_abnormal_immune_serum2.09134374
33MP0003172_abnormal_lysosome_physiology2.07424529
34MP0000604_amyloidosis2.02854294
35MP0002420_abnormal_adaptive_immunity1.99625176
36MP0002452_abnormal_antigen_presenting1.99508077
37MP0001819_abnormal_immune_cell1.95807728
38MP0000343_altered_response_to1.94755892
39MP0001853_heart_inflammation1.94469524
40MP0005451_abnormal_body_composition1.91488507
41MP0005387_immune_system_phenotype1.84473592
42MP0001790_abnormal_immune_system1.84473592
43MP0001545_abnormal_hematopoietic_system1.82464073
44MP0005397_hematopoietic_system_phenotyp1.82464073
45MP0001800_abnormal_humoral_immune1.79753715
46MP0000685_abnormal_immune_system1.79240918
47MP0002396_abnormal_hematopoietic_system1.77486790
48MP0001672_abnormal_embryogenesis/_devel1.75904928
49MP0005380_embryogenesis_phenotype1.75904928
50MP0003786_premature_aging1.72818226
51MP0001697_abnormal_embryo_size1.70832126
52MP0006292_abnormal_olfactory_placode1.69978463
53MP0008260_abnormal_autophagy1.69012436
54MP0002080_prenatal_lethality1.68126676
55MP0003656_abnormal_erythrocyte_physiolo1.66250383
56MP0003448_altered_tumor_morphology1.65578757
57MP0003329_amyloid_beta_deposits1.64460098
58MP0000313_abnormal_cell_death1.61501384
59MP0001533_abnormal_skeleton_physiology1.56730368
60MP0004947_skin_inflammation1.56667890
61MP0002019_abnormal_tumor_incidence1.54387535
62MP0010352_gastrointestinal_tract_polyps1.51686828
63MP0001845_abnormal_inflammatory_respons1.51410610
64MP0003984_embryonic_growth_retardation1.50137960
65MP0002405_respiratory_system_inflammati1.47626123
66MP0002088_abnormal_embryonic_growth/wei1.44869156
67MP0000490_abnormal_crypts_of1.42754369
68MP0002210_abnormal_sex_determination1.39674347
69MP0009764_decreased_sensitivity_to1.39040586
70MP0002132_abnormal_respiratory_system1.38574749
71MP0000015_abnormal_ear_pigmentation1.38137677
72MP0002085_abnormal_embryonic_tissue1.37606360
73MP0003453_abnormal_keratinocyte_physiol1.37554789
74MP0008469_abnormal_protein_level1.36505433
75MP0005166_decreased_susceptibility_to1.34312749
76MP0010307_abnormal_tumor_latency1.32574428
77MP0004808_abnormal_hematopoietic_stem1.32535767
78MP0009278_abnormal_bone_marrow1.31899990
79MP0003763_abnormal_thymus_physiology1.30315266
80MP0000750_abnormal_muscle_regeneration1.27534614
81MP0005423_abnormal_somatic_nervous1.25907500
82MP0002086_abnormal_extraembryonic_tissu1.25408247
83MP0002084_abnormal_developmental_patter1.25022669
84MP0010030_abnormal_orbit_morphology1.23892477
85MP0003724_increased_susceptibility_to1.23831123
86MP0001873_stomach_inflammation1.22795974
87MP0005171_absent_coat_pigmentation1.22671869
88MP0010155_abnormal_intestine_physiology1.21321704
89MP0006036_abnormal_mitochondrial_physio1.21217847
90MP0009672_abnormal_birth_weight1.19435158
91MP0005165_increased_susceptibility_to1.19030281
92MP0002160_abnormal_reproductive_system1.18608721
93MP0001929_abnormal_gametogenesis1.17187509
94MP0003646_muscle_fatigue1.16659438
95MP0001542_abnormal_bone_strength1.14373753
96MP0000689_abnormal_spleen_morphology1.12600412
97MP0000358_abnormal_cell_content/1.12485014
98MP0004381_abnormal_hair_follicle1.12351158
99MP0003183_abnormal_peptide_metabolism1.12329510
100MP0003315_abnormal_perineum_morphology1.12207420
101MP0001145_abnormal_male_reproductive1.10405628
102MP0002398_abnormal_bone_marrow1.09932806
103MP0002722_abnormal_immune_system1.09687938
104MP0003119_abnormal_digestive_system1.09252648
105MP0003890_abnormal_embryonic-extraembry1.08197286
106MP0000703_abnormal_thymus_morphology1.05643611
107MP0000653_abnormal_sex_gland1.01547507
108MP0002998_abnormal_bone_remodeling0.98477751
109MP0005310_abnormal_salivary_gland0.98160631
110MP0008874_decreased_physiological_sensi0.97185364
111MP0003221_abnormal_cardiomyocyte_apopto0.95584856
112MP0000920_abnormal_myelination0.93941462
113MP0003191_abnormal_cellular_cholesterol0.93442183
114MP0005584_abnormal_enzyme/coenzyme_acti0.91684216
115MP0001986_abnormal_taste_sensitivity0.91680808
116MP0006035_abnormal_mitochondrial_morpho0.91212848
117MP0001119_abnormal_female_reproductive0.89928878
118MP0001849_ear_inflammation0.88708298
119MP0000465_gastrointestinal_hemorrhage0.88420104
120MP0003283_abnormal_digestive_organ0.88020374
121MP0004197_abnormal_fetal_growth/weight/0.87834417
122MP0001905_abnormal_dopamine_level0.87638103
123MP0002254_reproductive_system_inflammat0.86714866
124MP0002429_abnormal_blood_cell0.86264413
125MP0003186_abnormal_redox_activity0.84162077
126MP0005167_abnormal_blood-brain_barrier0.83704486
127MP0002933_joint_inflammation0.83394295
128MP0001727_abnormal_embryo_implantation0.82313936
129MP0000858_altered_metastatic_potential0.82024949
130MP0005389_reproductive_system_phenotype0.81761585
131MP0005621_abnormal_cell_physiology0.81696142
132MP0003303_peritoneal_inflammation0.81403462
133MP0006054_spinal_hemorrhage0.81068208
134MP0001293_anophthalmia0.80606593
135MP0005384_cellular_phenotype0.80323470
136MP0005670_abnormal_white_adipose0.79678059
137MP0005395_other_phenotype0.79284481
138MP0005330_cardiomyopathy0.79236697
139MP0003699_abnormal_female_reproductive0.78856646
140MP0003300_gastrointestinal_ulcer0.78029290
141MP0009763_increased_sensitivity_to0.77841908
142MP0005390_skeleton_phenotype0.77305916
143MP0003567_abnormal_fetal_cardiomyocyte0.75424319
144MP0003279_aneurysm0.73890128
145MP0003705_abnormal_hypodermis_morpholog0.72318669
146MP0000681_abnormal_thyroid_gland0.70383302
147MP0002269_muscular_atrophy0.70201483
148MP0004858_abnormal_nervous_system0.70087717
149MP0004133_heterotaxia0.69018652
150MP0000716_abnormal_immune_system0.68337079
151MP0001919_abnormal_reproductive_system0.68094404
152MP0000747_muscle_weakness0.67507602
153MP0002161_abnormal_fertility/fecundity0.65605078
154MP0001243_abnormal_dermal_layer0.65422656
155MP0000598_abnormal_liver_morphology0.65112987
156MP0003690_abnormal_glial_cell0.63836369
157MP0003879_abnormal_hair_cell0.63717101
158MP0003121_genomic_imprinting0.63245402
159MP0005174_abnormal_tail_pigmentation0.62947462
160MP0003136_yellow_coat_color0.58396206
161MP0005023_abnormal_wound_healing0.55626823
162MP0008770_decreased_survivor_rate0.55420111
163MP0004233_abnormal_muscle_weight0.55129356
164MP0005075_abnormal_melanosome_morpholog0.52873897
165MP0000477_abnormal_intestine_morphology0.51083165
166MP0003698_abnormal_male_reproductive0.49867562
167MP0002075_abnormal_coat/hair_pigmentati0.49638380
168MP0003866_abnormal_defecation0.49630808
169MP0005464_abnormal_platelet_physiology0.47753335

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.72163302
2Abnormality of glycolipid metabolism (HP:0010969)5.59405111
3Abnormality of liposaccharide metabolism (HP:0010968)5.59405111
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.59405111
5Cerebral hypomyelination (HP:0006808)4.98533781
6Abnormality of the anterior horn cell (HP:0006802)4.74551728
7Degeneration of anterior horn cells (HP:0002398)4.74551728
8Breast hypoplasia (HP:0003187)4.40911082
9Patellar aplasia (HP:0006443)3.97190640
10Aplasia/Hypoplasia of the patella (HP:0006498)3.91017707
11Increased cerebral lipofuscin (HP:0011813)3.87182951
12Carpal bone hypoplasia (HP:0001498)3.69510961
13Abnormality of macrophages (HP:0004311)3.64370703
14Dysostosis multiplex (HP:0000943)3.53596245
15Premature ovarian failure (HP:0008209)3.49738347
16Aplastic anemia (HP:0001915)3.48864083
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.44463784
18Vertebral compression fractures (HP:0002953)3.33241971
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.32650964
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.32650964
21Microretrognathia (HP:0000308)3.32274173
22Vacuolated lymphocytes (HP:0001922)3.27862933
23Recurrent abscess formation (HP:0002722)3.22724063
24Secondary amenorrhea (HP:0000869)3.20935063
25Abnormality of cells of the erythroid lineage (HP:0012130)3.18729190
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15818568
27Selective tooth agenesis (HP:0001592)3.10204073
28Abnormal number of erythroid precursors (HP:0012131)3.09585674
29Loss of speech (HP:0002371)3.08360028
30Rough bone trabeculation (HP:0100670)3.04968945
31Obstructive lung disease (HP:0006536)3.01773026
32Chronic obstructive pulmonary disease (HP:0006510)3.01773026
33Impulsivity (HP:0100710)2.97216408
34Mediastinal lymphadenopathy (HP:0100721)2.95685026
35Progressive muscle weakness (HP:0003323)2.94482919
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.93968622
37Medulloblastoma (HP:0002885)2.93327785
38Atrophy/Degeneration involving motor neurons (HP:0007373)2.92392029
39Increased intramyocellular lipid droplets (HP:0012240)2.91511371
40Multiple enchondromatosis (HP:0005701)2.90657304
41Axonal loss (HP:0003447)2.89312823
42CNS hypomyelination (HP:0003429)2.88098427
43Chromsome breakage (HP:0040012)2.87510193
44Ragged-red muscle fibers (HP:0003200)2.84832803
45Recurrent bacterial skin infections (HP:0005406)2.82761404
46Increased IgM level (HP:0003496)2.81751703
47Meckel diverticulum (HP:0002245)2.81305818
48Systemic lupus erythematosus (HP:0002725)2.81206776
49Oral leukoplakia (HP:0002745)2.81130585
50Unsteady gait (HP:0002317)2.80821864
51Mutism (HP:0002300)2.79713080
52Purpura (HP:0000979)2.75366753
53Increased muscle lipid content (HP:0009058)2.74257315
54Overlapping toe (HP:0001845)2.73724341
55Elevated erythrocyte sedimentation rate (HP:0003565)2.73315487
56Petechiae (HP:0000967)2.72130500
57Colon cancer (HP:0003003)2.68992255
58Disinhibition (HP:0000734)2.68899507
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.67521256
60Abnormality of the ileum (HP:0001549)2.67409048
61Slender long bone (HP:0003100)2.66856242
62Autoimmune thrombocytopenia (HP:0001973)2.65590611
63Eczematoid dermatitis (HP:0000976)2.65546272
64Abnormality of the preputium (HP:0100587)2.64125473
65Trismus (HP:0000211)2.61781822
66Reticulocytopenia (HP:0001896)2.61386600
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57535573
68Hepatosplenomegaly (HP:0001433)2.53625142
69Apathy (HP:0000741)2.52745330
70Progressive neurologic deterioration (HP:0002344)2.48552613
71Neuronal loss in central nervous system (HP:0002529)2.48506929
72Diminished motivation (HP:0000745)2.48247328
73Increased serum ferritin (HP:0003281)2.45991298
74Prolonged neonatal jaundice (HP:0006579)2.45380105
75Muscle fiber atrophy (HP:0100295)2.44144727
76Stomatitis (HP:0010280)2.42359543
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41533063
78Abnormality of the labia minora (HP:0012880)2.40571102
79Personality changes (HP:0000751)2.40254919
80Abnormality of polysaccharide metabolism (HP:0011012)2.38139548
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38139548
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38139548
83Neurofibrillary tangles (HP:0002185)2.36756344
84Prominent nose (HP:0000448)2.34120537
85Testicular atrophy (HP:0000029)2.34003886
86Mesangial abnormality (HP:0001966)2.32765819
87Abnormality of the motor neurons (HP:0002450)2.32063280
88Abnormal neuron morphology (HP:0012757)2.32063280
89Delusions (HP:0000746)2.31310563
90Aplasia/Hypoplasia of the uvula (HP:0010293)2.27350681
91Bone marrow hypocellularity (HP:0005528)2.27238493
92Macrocytic anemia (HP:0001972)2.24666062
93Small intestinal stenosis (HP:0012848)2.23618273
94Duodenal stenosis (HP:0100867)2.23618273
95Pallor (HP:0000980)2.22643430
96Myelodysplasia (HP:0002863)2.21310320
97Hepatocellular necrosis (HP:0001404)2.18052282
98Ependymoma (HP:0002888)2.17546234
99Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16787378
100Death in infancy (HP:0001522)2.16667042
101Abnormal mitochondria in muscle tissue (HP:0008316)2.16391230
102Mitochondrial inheritance (HP:0001427)2.15679561
103Neoplasm of the pancreas (HP:0002894)2.15650974
104Horseshoe kidney (HP:0000085)2.15423904
105Breast aplasia (HP:0100783)2.15140713
106Mucopolysacchariduria (HP:0008155)2.14844629
107Urinary glycosaminoglycan excretion (HP:0003541)2.14844629
108Absent radius (HP:0003974)2.14186821
109Absent thumb (HP:0009777)2.13303639
110Achilles tendon contracture (HP:0001771)2.12721103
111Upper motor neuron abnormality (HP:0002127)2.12448896
112Type 2 muscle fiber atrophy (HP:0003554)2.11542202
113Renal Fanconi syndrome (HP:0001994)2.10367629
114J-shaped sella turcica (HP:0002680)2.10351911
115Sloping forehead (HP:0000340)2.08892063
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08890983
117Abnormality of alanine metabolism (HP:0010916)2.08890983
118Hyperalaninemia (HP:0003348)2.08890983
119Postnatal microcephaly (HP:0005484)2.07739718
120Visual hallucinations (HP:0002367)2.07662088
121Thrombocytosis (HP:0001894)2.06438651
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06122539
123Abnormality of chromosome stability (HP:0003220)2.06067502
124Amyloidosis (HP:0011034)2.05692388
125Cerebral inclusion bodies (HP:0100314)2.05236466
126Nuclear cataract (HP:0100018)2.05050673
127Cutaneous melanoma (HP:0012056)2.04848208
128Distal lower limb muscle weakness (HP:0009053)2.03625271
129Hypertensive crisis (HP:0100735)2.03123578
130Supranuclear gaze palsy (HP:0000605)2.01652849
131Aplasia/Hypoplasia of the breasts (HP:0010311)2.01348449
132Abnormal gallbladder physiology (HP:0012438)1.99999883
133Cholecystitis (HP:0001082)1.99999883
134Recurrent fungal infections (HP:0002841)1.99888502
135Meningitis (HP:0001287)1.99582418
136Premature graying of hair (HP:0002216)1.99347166
137Recurrent skin infections (HP:0001581)1.99262288
138Abnormal trabecular bone morphology (HP:0100671)1.98936416
139Abnormal spermatogenesis (HP:0008669)1.98923622
140Emotional lability (HP:0000712)1.97729540
141Tetraplegia (HP:0002445)1.97568342
142Atresia of the external auditory canal (HP:0000413)1.97301553
143Cellulitis (HP:0100658)1.97287673
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97170812
145Sparse eyelashes (HP:0000653)1.96219543
146Pancreatic fibrosis (HP:0100732)1.94925945
147Agammaglobulinemia (HP:0004432)1.94669843
148Absent forearm bone (HP:0003953)1.94351120
149Aplasia involving forearm bones (HP:0009822)1.94351120
150Hypergammaglobulinemia (HP:0010702)1.93882248
151Dementia (HP:0000726)1.93767395
152Abnormality of the heme biosynthetic pathway (HP:0010472)1.93590177
153Recurrent cutaneous fungal infections (HP:0011370)1.92119912
154Chronic mucocutaneous candidiasis (HP:0002728)1.92119912
155Tracheoesophageal fistula (HP:0002575)1.92055842
156Annular pancreas (HP:0001734)1.90686760
157Tongue fasciculations (HP:0001308)1.89935706
158Pancreatic cysts (HP:0001737)1.89887178
159Increased serum lactate (HP:0002151)1.89387596
160CNS demyelination (HP:0007305)1.89372959
161Deformed tarsal bones (HP:0008119)1.88639922
162Combined immunodeficiency (HP:0005387)1.88475177
163Entropion (HP:0000621)1.86684273
164Hyperglycinemia (HP:0002154)1.84470254
165Megaloblastic anemia (HP:0001889)1.82308451
166Cleft eyelid (HP:0000625)1.82229367
167Hepatic necrosis (HP:0002605)1.82184288
168Recurrent viral infections (HP:0004429)1.81015814
169Abnormality of the duodenum (HP:0002246)1.80650922
170Abnormality of the Achilles tendon (HP:0005109)1.80396987
171Acute necrotizing encephalopathy (HP:0006965)1.79288280
172Urticaria (HP:0001025)1.79111296
173Cellular immunodeficiency (HP:0005374)1.77830255
174Muscle fibrillation (HP:0010546)1.77283823
175Patent foramen ovale (HP:0001655)1.77127955
176Areflexia of lower limbs (HP:0002522)1.76772281
177Joint stiffness (HP:0001387)1.75483931
178Polygenic inheritance (HP:0010982)1.75187910
179Increased CSF lactate (HP:0002490)1.74244288
180Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73293060
181Pancytopenia (HP:0001876)1.73007493
182Type I transferrin isoform profile (HP:0003642)1.72239551
183Myositis (HP:0100614)1.72061014
184Triphalangeal thumb (HP:0001199)1.72012869
185Spastic paraparesis (HP:0002313)1.71825661
186Hyperglycinuria (HP:0003108)1.70175351
187True hermaphroditism (HP:0010459)1.69520867
188Short thumb (HP:0009778)1.68949035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.44502663
2PLK43.42999067
3VRK23.36281472
4WEE13.33760571
5NEK23.11332981
6TESK23.10933829
7EIF2AK12.91322035
8BRSK22.76255339
9NME22.65304529
10CDC72.36287764
11ERN12.23099445
12TTK2.21520896
13TSSK62.07879810
14NEK12.05147056
15SMG11.99006819
16BRSK11.97851590
17TAOK21.96603257
18PLK11.96260286
19RPS6KA41.95380368
20PRPF4B1.92308335
21SRPK11.89428610
22CCNB11.89181815
23DYRK31.88141339
24STK161.85227523
25TBK11.81169621
26ACVR1B1.78959580
27LATS21.70994946
28TRIB31.70192939
29RIPK41.54743470
30TLK11.46679267
31PLK31.42659223
32AURKB1.41063638
33SCYL21.39474449
34BLK1.36073608
35EIF2AK31.32549831
36EPHA21.28585794
37BRAF1.28557077
38CAMKK21.26850147
39MAP3K121.21449893
40TESK11.20736478
41ALK1.20579205
42IKBKB1.20237828
43FES1.19828676
44AURKA1.19550552
45TXK1.17831305
46VRK11.17409054
47RPS6KB21.17304880
48CDK71.15975716
49MAP3K81.15696770
50CHEK21.12694599
51PAK41.12123155
52ATR1.10144460
53STK101.08685910
54KDR1.07607279
55MAP2K31.07148805
56MKNK11.03265449
57MKNK20.97417375
58MAP3K110.97411533
59CDK40.96724731
60CSK0.94309253
61CHEK10.92028785
62EEF2K0.89774404
63IKBKE0.89365258
64MAP3K140.88215013
65PAK10.86760588
66BCKDK0.86750099
67STK38L0.84372424
68TAOK10.82061151
69CSF1R0.81772290
70ZAP700.81540603
71CDK11A0.79049252
72CDK150.75448256
73PKN20.75396395
74MAPKAPK30.74922596
75IRAK40.74036642
76MAP3K30.73926260
77LRRK20.73794554
78IRAK20.73060222
79MAP4K10.72891710
80ZAK0.72841321
81CDK20.72154160
82CDK140.71890548
83CDK180.71725407
84SYK0.71683124
85AKT30.70204840
86GRK60.70134108
87MAP2K20.70081244
88TNK20.69927863
89MAP3K10.69745700
90PIM20.69454777
91SIK30.69108828
92LIMK10.68606625
93MAP3K100.68369672
94CDK80.66728288
95MAPK110.65285239
96DYRK20.64515998
97SIK20.62923948
98CDK120.60397733
99CSNK1G30.60131308
100BMX0.58760160
101MOS0.58013878
102CSNK2A10.57211716
103PRKD30.57100263
104CDK190.56717488
105ARAF0.56032438
106PAK60.55979116
107PASK0.55903313
108YES10.55536902
109CSNK2A20.55211836
110ABL20.52926333
111IRAK30.51812710
112AKT20.51754178
113ILK0.50719814
114NME10.49601906
115LYN0.49359359
116PIM10.48416686
117MAP3K130.47372271
118BTK0.47162551
119RPS6KA50.46025185
120KIT0.45776905
121GRK70.45389267
122FGR0.45005647
123PDPK10.44348374
124* CDK10.44178999
125CSNK1A1L0.44151080
126CAMK2G0.41991987
127PDK30.41677500
128PDK40.41677500
129MARK30.41528519
130TYRO30.40015689
131JAK30.39240348
132PRKCI0.38878962
133LCK0.35925377
134TYK20.34755296
135TGFBR20.34397704
136ATM0.33143884
137MAPKAPK20.32943498
138SIK10.32876328
139BMPR20.32765563
140CDK90.32561777
141MAP3K50.31512090
142GRK50.31110031
143CAMKK10.30568433
144HCK0.30124287
145RIPK10.29804651
146DAPK30.29671491
147DAPK10.29502323
148MATK0.28886847
149CSNK1E0.28508000
150MAPK40.28282834
151PINK10.27755515
152LMTK20.26913880
153STK40.26101694
154TGFBR10.24669765
155PRKD20.23067999
156RAF10.22943035

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.36414890
2RNA polymerase_Homo sapiens_hsa030204.05426424
3Proteasome_Homo sapiens_hsa030504.01723096
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79049003
5Spliceosome_Homo sapiens_hsa030403.53004648
6Mismatch repair_Homo sapiens_hsa034303.48217175
7Ribosome_Homo sapiens_hsa030103.26753518
8Base excision repair_Homo sapiens_hsa034103.23537775
9Other glycan degradation_Homo sapiens_hsa005113.22172677
10RNA transport_Homo sapiens_hsa030133.12204012
11Pyrimidine metabolism_Homo sapiens_hsa002402.78465955
12Vitamin B6 metabolism_Homo sapiens_hsa007502.55540559
13Homologous recombination_Homo sapiens_hsa034402.54421796
14Lysosome_Homo sapiens_hsa041422.51978826
15Cell cycle_Homo sapiens_hsa041102.50572068
16Graft-versus-host disease_Homo sapiens_hsa053322.35820318
17Nucleotide excision repair_Homo sapiens_hsa034202.25010506
18Allograft rejection_Homo sapiens_hsa053302.20850949
19Rheumatoid arthritis_Homo sapiens_hsa053232.19938303
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18998485
21Glycosaminoglycan degradation_Homo sapiens_hsa005312.14764648
22One carbon pool by folate_Homo sapiens_hsa006702.09150182
23Autoimmune thyroid disease_Homo sapiens_hsa053201.99939206
24Salmonella infection_Homo sapiens_hsa051321.89389199
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87960122
26Oxidative phosphorylation_Homo sapiens_hsa001901.81827592
27Basal transcription factors_Homo sapiens_hsa030221.79459457
28Asthma_Homo sapiens_hsa053101.76357033
29Folate biosynthesis_Homo sapiens_hsa007901.71047214
30Leishmaniasis_Homo sapiens_hsa051401.70384720
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.67361241
32RNA degradation_Homo sapiens_hsa030181.67233323
33Fanconi anemia pathway_Homo sapiens_hsa034601.62557114
34Osteoclast differentiation_Homo sapiens_hsa043801.62556947
35Purine metabolism_Homo sapiens_hsa002301.58091008
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.57415087
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.54895946
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.50331358
39p53 signaling pathway_Homo sapiens_hsa041151.48590832
40Non-homologous end-joining_Homo sapiens_hsa034501.46827309
41Sulfur relay system_Homo sapiens_hsa041221.46123615
42Pentose phosphate pathway_Homo sapiens_hsa000301.43158532
43Biosynthesis of amino acids_Homo sapiens_hsa012301.41939441
44Tuberculosis_Homo sapiens_hsa051521.41912532
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40287358
46Vibrio cholerae infection_Homo sapiens_hsa051101.37234937
47Viral myocarditis_Homo sapiens_hsa054161.36944648
48Staphylococcus aureus infection_Homo sapiens_hsa051501.35514588
49mRNA surveillance pathway_Homo sapiens_hsa030151.33225812
50Epstein-Barr virus infection_Homo sapiens_hsa051691.26334467
51Selenocompound metabolism_Homo sapiens_hsa004501.24516814
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.24490469
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24439564
54Collecting duct acid secretion_Homo sapiens_hsa049661.23368240
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23186038
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22076895
57Synaptic vesicle cycle_Homo sapiens_hsa047211.19749431
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18201006
59Type I diabetes mellitus_Homo sapiens_hsa049401.16975389
60Phagosome_Homo sapiens_hsa041451.16941034
61Prion diseases_Homo sapiens_hsa050201.16274345
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16022699
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10018148
64Hematopoietic cell lineage_Homo sapiens_hsa046401.09232403
65SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08128712
66Pertussis_Homo sapiens_hsa051331.05768926
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03228921
68B cell receptor signaling pathway_Homo sapiens_hsa046621.01925298
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01077730
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00350064
71Alzheimers disease_Homo sapiens_hsa050100.99315201
72Oocyte meiosis_Homo sapiens_hsa041140.99311076
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96639106
74Malaria_Homo sapiens_hsa051440.96245082
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93969583
76Carbon metabolism_Homo sapiens_hsa012000.93963104
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93383818
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91440743
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88022524
80Influenza A_Homo sapiens_hsa051640.87977907
81Regulation of autophagy_Homo sapiens_hsa041400.87460847
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86735975
83Thyroid cancer_Homo sapiens_hsa052160.84948056
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84408675
85TNF signaling pathway_Homo sapiens_hsa046680.83494953
86T cell receptor signaling pathway_Homo sapiens_hsa046600.82263895
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79606399
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78887423
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78689275
90Endocytosis_Homo sapiens_hsa041440.77754117
91Toxoplasmosis_Homo sapiens_hsa051450.75067411
92Fructose and mannose metabolism_Homo sapiens_hsa000510.72583407
93Systemic lupus erythematosus_Homo sapiens_hsa053220.71946128
94Herpes simplex infection_Homo sapiens_hsa051680.67336871
95Sulfur metabolism_Homo sapiens_hsa009200.65374169
96VEGF signaling pathway_Homo sapiens_hsa043700.62171312
97HTLV-I infection_Homo sapiens_hsa051660.61712630
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58843255
99Viral carcinogenesis_Homo sapiens_hsa052030.57214361
100Circadian rhythm_Homo sapiens_hsa047100.53485113
101Galactose metabolism_Homo sapiens_hsa000520.52504581
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50783056
103Antigen processing and presentation_Homo sapiens_hsa046120.45761763
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45255003
105N-Glycan biosynthesis_Homo sapiens_hsa005100.44412031
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44153852
107Huntingtons disease_Homo sapiens_hsa050160.43130664
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43104412
109Chemokine signaling pathway_Homo sapiens_hsa040620.43084309
110Glutathione metabolism_Homo sapiens_hsa004800.42409221
111Hepatitis C_Homo sapiens_hsa051600.40111514
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38667106
113Arginine and proline metabolism_Homo sapiens_hsa003300.38472121
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36996576
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.36136124
116Primary immunodeficiency_Homo sapiens_hsa053400.35874659
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34186968
118Shigellosis_Homo sapiens_hsa051310.33450148
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32799758
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32430651
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.30845687
122Acute myeloid leukemia_Homo sapiens_hsa052210.30774130
123Sphingolipid metabolism_Homo sapiens_hsa006000.30704999
124Metabolic pathways_Homo sapiens_hsa011000.30617730
125Legionellosis_Homo sapiens_hsa051340.29304467
126Apoptosis_Homo sapiens_hsa042100.29027389
127Notch signaling pathway_Homo sapiens_hsa043300.28643413
128Hippo signaling pathway_Homo sapiens_hsa043900.27031449
129Parkinsons disease_Homo sapiens_hsa050120.26346949
130Alcoholism_Homo sapiens_hsa050340.26328543
131Colorectal cancer_Homo sapiens_hsa052100.25249459
132HIF-1 signaling pathway_Homo sapiens_hsa040660.24448074
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23912612
134Bladder cancer_Homo sapiens_hsa052190.22872518
135Basal cell carcinoma_Homo sapiens_hsa052170.20219405
136Chronic myeloid leukemia_Homo sapiens_hsa052200.20012456
137Small cell lung cancer_Homo sapiens_hsa052220.19642003
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15704300
139mTOR signaling pathway_Homo sapiens_hsa041500.14754306
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13454500
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12501596
142Pyruvate metabolism_Homo sapiens_hsa006200.12390218
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11586538
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11260972
145Protein export_Homo sapiens_hsa030600.11110472
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09972729
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.09770060
148Hepatitis B_Homo sapiens_hsa051610.09072987
149MicroRNAs in cancer_Homo sapiens_hsa052060.08915945
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07845566
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06596408
152Measles_Homo sapiens_hsa051620.06537956
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.06032681
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05590036
155beta-Alanine metabolism_Homo sapiens_hsa004100.04877963
156Insulin signaling pathway_Homo sapiens_hsa049100.04627872

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