TFR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.98537782
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54143030
3L-phenylalanine catabolic process (GO:0006559)7.54143030
4epoxygenase P450 pathway (GO:0019373)7.22058408
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21561104
6L-phenylalanine metabolic process (GO:0006558)7.21561104
7omega-hydroxylase P450 pathway (GO:0097267)7.11819905
8aromatic amino acid family catabolic process (GO:0009074)6.82311726
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.31494448
10tryptophan catabolic process (GO:0006569)6.22656680
11indole-containing compound catabolic process (GO:0042436)6.22656680
12indolalkylamine catabolic process (GO:0046218)6.22656680
13kynurenine metabolic process (GO:0070189)6.04586272
14bile acid biosynthetic process (GO:0006699)5.98016982
15tryptophan metabolic process (GO:0006568)5.86539372
16glyoxylate metabolic process (GO:0046487)5.78627441
17urea cycle (GO:0000050)5.67710456
18urea metabolic process (GO:0019627)5.67710456
19negative regulation of fibrinolysis (GO:0051918)5.64556143
20high-density lipoprotein particle remodeling (GO:0034375)5.56531119
21alpha-linolenic acid metabolic process (GO:0036109)5.52828146
22regulation of fibrinolysis (GO:0051917)5.48256617
23regulation of protein activation cascade (GO:2000257)5.47066248
24complement activation, alternative pathway (GO:0006957)5.41645766
25peptidyl-glutamic acid carboxylation (GO:0017187)5.40325151
26protein carboxylation (GO:0018214)5.40325151
27cysteine metabolic process (GO:0006534)5.37993972
28sulfur amino acid catabolic process (GO:0000098)5.30576827
29oxidative demethylation (GO:0070989)5.26279360
30regulation of plasminogen activation (GO:0010755)5.25582646
31drug metabolic process (GO:0017144)5.25242320
32nitrogen cycle metabolic process (GO:0071941)5.22440882
33serine family amino acid catabolic process (GO:0009071)5.12025046
34regulation of complement activation (GO:0030449)5.09867134
35bile acid metabolic process (GO:0008206)5.08307606
36aromatic amino acid family metabolic process (GO:0009072)4.95785586
37ethanol metabolic process (GO:0006067)4.95113753
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91010049
39regulation of cholesterol esterification (GO:0010872)4.86905034
40reverse cholesterol transport (GO:0043691)4.84807254
41regulation of triglyceride catabolic process (GO:0010896)4.84407075
42macromolecular complex remodeling (GO:0034367)4.78024765
43plasma lipoprotein particle remodeling (GO:0034369)4.78024765
44protein-lipid complex remodeling (GO:0034368)4.78024765
45tyrosine metabolic process (GO:0006570)4.75441028
46homocysteine metabolic process (GO:0050667)4.72167460
47amino-acid betaine metabolic process (GO:0006577)4.66483352
48alpha-amino acid catabolic process (GO:1901606)4.65522255
49lysine metabolic process (GO:0006553)4.62826844
50lysine catabolic process (GO:0006554)4.62826844
51S-adenosylmethionine metabolic process (GO:0046500)4.60376023
52triglyceride homeostasis (GO:0070328)4.59369794
53acylglycerol homeostasis (GO:0055090)4.59369794
54phospholipid efflux (GO:0033700)4.56138842
55regulation of humoral immune response (GO:0002920)4.54115791
56imidazole-containing compound metabolic process (GO:0052803)4.52985439
57negative regulation of cholesterol transport (GO:0032375)4.51722066
58negative regulation of sterol transport (GO:0032372)4.51722066
59glycine metabolic process (GO:0006544)4.49699929
60indolalkylamine metabolic process (GO:0006586)4.41598746
61bile acid and bile salt transport (GO:0015721)4.40977878
62phenylpropanoid metabolic process (GO:0009698)4.39937394
63coenzyme catabolic process (GO:0009109)4.38492331
64cellular ketone body metabolic process (GO:0046950)4.38153864
65negative regulation of hemostasis (GO:1900047)4.35971277
66negative regulation of blood coagulation (GO:0030195)4.35971277
67amine catabolic process (GO:0009310)4.34682718
68cellular biogenic amine catabolic process (GO:0042402)4.34682718
69plasma lipoprotein particle clearance (GO:0034381)4.31724786
70cellular amino acid catabolic process (GO:0009063)4.26056993
71negative regulation of protein activation cascade (GO:2000258)4.24614673
72cholesterol efflux (GO:0033344)4.23104901
73serine family amino acid metabolic process (GO:0009069)4.21957973
74glutamate metabolic process (GO:0006536)4.19640309
75cellular glucuronidation (GO:0052695)4.14348231
76blood coagulation, intrinsic pathway (GO:0007597)4.14305194
77ethanol oxidation (GO:0006069)4.12744135
78intestinal cholesterol absorption (GO:0030299)4.10215927
79benzene-containing compound metabolic process (GO:0042537)4.09788561
80arginine metabolic process (GO:0006525)4.06472930
81serine family amino acid biosynthetic process (GO:0009070)4.06051762
82low-density lipoprotein particle remodeling (GO:0034374)4.06010546
83plasma lipoprotein particle assembly (GO:0034377)4.03976761
84killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.02880910
85disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.02880910
86positive regulation of blood coagulation (GO:0030194)4.01484972
87positive regulation of hemostasis (GO:1900048)4.01484972
88fibrinolysis (GO:0042730)4.00426709
89aldehyde catabolic process (GO:0046185)3.98432729
90regulation of apoptotic cell clearance (GO:2000425)3.98092154
91cellular modified amino acid catabolic process (GO:0042219)3.98039338
92cofactor catabolic process (GO:0051187)3.90308064
93negative regulation of coagulation (GO:0050819)3.89338887
94dicarboxylic acid biosynthetic process (GO:0043650)3.86437017
95complement activation, classical pathway (GO:0006958)3.85886536
96positive regulation of lipoprotein lipase activity (GO:0051006)3.85803767
97positive regulation of triglyceride lipase activity (GO:0061365)3.85803767
98protein activation cascade (GO:0072376)3.85043049
99negative regulation of wound healing (GO:0061045)3.82128432
100alkaloid metabolic process (GO:0009820)3.81792888
101complement activation (GO:0006956)3.80327122
102ketone body metabolic process (GO:1902224)3.78692015
103very-low-density lipoprotein particle assembly (GO:0034379)3.77143707
104NAD biosynthetic process (GO:0009435)3.77047202
105negative regulation of lipase activity (GO:0060192)3.75677163
106drug catabolic process (GO:0042737)3.75093265
107organic acid catabolic process (GO:0016054)3.73969441
108carboxylic acid catabolic process (GO:0046395)3.73969441
109positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.72976301
110proline metabolic process (GO:0006560)3.72723607
111positive regulation of fatty acid biosynthetic process (GO:0045723)3.70309502
112cholesterol homeostasis (GO:0042632)3.69809613
113cytolysis (GO:0019835)3.69083394
114nicotinamide nucleotide biosynthetic process (GO:0019359)3.68300491
115pyridine nucleotide biosynthetic process (GO:0019363)3.68300491
116opsonization (GO:0008228)3.67146066
117plasma lipoprotein particle organization (GO:0071827)3.65627043
118glucuronate metabolic process (GO:0019585)3.64260706
119uronic acid metabolic process (GO:0006063)3.64260706
120positive regulation of lipid catabolic process (GO:0050996)3.64147352
121regulation of bile acid biosynthetic process (GO:0070857)3.63268529
122acute-phase response (GO:0006953)3.63237670
123phospholipid homeostasis (GO:0055091)3.62815860
124sterol homeostasis (GO:0055092)3.62726730
125positive regulation of coagulation (GO:0050820)3.62693564
126short-chain fatty acid metabolic process (GO:0046459)3.59154990
127oxaloacetate metabolic process (GO:0006107)3.53596555
128protoporphyrinogen IX metabolic process (GO:0046501)3.53232688
129protein-lipid complex subunit organization (GO:0071825)3.48597229
130arginine catabolic process (GO:0006527)3.43856152
131regulation of lipoprotein particle clearance (GO:0010984)3.40962764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.38822897
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19063321
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.16464462
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.39280764
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.39085084
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.30452665
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.87289131
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.29926236
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87430063
10GATA1_22025678_ChIP-Seq_K562_Human2.15013327
11E2F7_22180533_ChIP-Seq_HELA_Human2.10846946
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04664252
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04267985
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0715990
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94716788
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74982943
17HTT_18923047_ChIP-ChIP_STHdh_Human1.61700952
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.45202943
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36036518
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34832410
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.31428900
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.31300664
23CLOCK_20551151_ChIP-Seq_293T_Human1.28905522
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26515836
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24097804
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21320935
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19497514
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18071683
29RAC3_21632823_ChIP-Seq_H3396_Human1.17848583
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11897033
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11186690
32* E2F1_20622854_ChIP-Seq_HELA_Human1.09339522
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07348839
34PHF8_20622854_ChIP-Seq_HELA_Human1.05591674
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01812007
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01357627
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00391177
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99962996
39NCOR1_26117541_ChIP-Seq_K562_Human0.99081989
40* P68_20966046_ChIP-Seq_HELA_Human0.94957785
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92303305
42P300_27268052_Chip-Seq_Bcells_Human0.91215059
43ERA_21632823_ChIP-Seq_H3396_Human0.90697479
44SPI1_20517297_ChIP-Seq_HL60_Human0.89606831
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89403681
46SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86373678
47SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86313263
48KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84967598
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82061645
50CTCF_20526341_ChIP-Seq_ESCs_Human0.81830244
51MYC_18555785_ChIP-Seq_MESCs_Mouse0.81482476
52SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80923550
53YY1_22570637_ChIP-Seq_MALME-3M_Human0.80876395
54SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80314237
55AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78362773
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78127765
57RARA_24833708_ChIP-Seq_LIVER_Mouse0.77948703
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77255313
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75257086
60GATA4_25053715_ChIP-Seq_YYC3_Human0.73677405
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73217356
62GATA1_19941827_ChIP-Seq_MEL_Mouse0.72191102
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71453713
64NANOG_20526341_ChIP-Seq_ESCs_Human0.71031756
65SCL_19346495_ChIP-Seq_HPC-7_Human0.70854858
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70854630
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69914342
68ZNF263_19887448_ChIP-Seq_K562_Human0.69056838
69RARB_24833708_ChIP-Seq_LIVER_Mouse0.68522921
70* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.68091748
71GABP_19822575_ChIP-Seq_HepG2_Human0.67751750
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67296864
73LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.66791596
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.66728903
75OCT4_20526341_ChIP-Seq_ESCs_Human0.66591369
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66217547
77ETS1_20019798_ChIP-Seq_JURKAT_Human0.65975808
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65726452
79SA1_27219007_Chip-Seq_Bcells_Human0.65713535
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64755471
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.64013224
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63925830
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63854449
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63668959
85MYC_19829295_ChIP-Seq_ESCs_Human0.63643527
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.63014835
87CTCF_21964334_Chip-Seq_Bcells_Human0.62765756
88RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62516094
89SMC4_20622854_ChIP-Seq_HELA_Human0.62420362
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.61867533
91CTCF_21964334_ChIP-Seq_BJAB-B_Human0.61520468
92FOXP1_21924763_ChIP-Seq_HESCs_Human0.60983138
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.60794581
94AR_20517297_ChIP-Seq_VCAP_Human0.60466608
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.59078190
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.57512145
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.56954295
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.56303154
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.55013913
100IRF1_19129219_ChIP-ChIP_H3396_Human0.54930124
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.53817461
102* CEBPB_22108803_ChIP-Seq_LS180_Human0.53692093
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.52178393
104MYC_19915707_ChIP-ChIP_AK7_Human0.50025388
105EGR1_19032775_ChIP-ChIP_M12_Human0.48669104
106P53_21459846_ChIP-Seq_SAOS-2_Human0.48640731
107LXR_22292898_ChIP-Seq_THP-1_Human0.48579471
108FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48284806
109* GATA1_19941826_ChIP-Seq_K562_Human0.48052694
110STAT1_17558387_ChIP-Seq_HELA_Human0.47880588
111ESET_19884257_ChIP-Seq_ESCs_Mouse0.47748889
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.45668995
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.45127568
114* GATA2_19941826_ChIP-Seq_K562_Human0.44950084
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.44180251
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44116184
117TAF2_19829295_ChIP-Seq_ESCs_Human0.44064219
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43532855
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42879432
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.42664686
121CBP_21632823_ChIP-Seq_H3396_Human0.42615450
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.42449622
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.40897399
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.40897399
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.40711384
126SRF_21415370_ChIP-Seq_HL-1_Mouse0.40598093
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40440888
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.40392504
129ERG_20517297_ChIP-Seq_VCAP_Human0.39665316
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39143592
131BRD4_27068464_Chip-Seq_AML-cells_Mouse0.38804547
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.38511457
133SPI1_26923725_Chip-Seq_HPCs_Mouse0.38211267
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.38151623
135CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.38030636
136SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.37741329
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.37140378
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36417217
139BCOR_27268052_Chip-Seq_Bcells_Human0.36223714
140BCL6_27268052_Chip-Seq_Bcells_Human0.35548481
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.35370689
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35034975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.22087942
2MP0005360_urolithiasis7.38374707
3MP0005085_abnormal_gallbladder_physiolo6.43846106
4MP0005365_abnormal_bile_salt6.17098223
5MP0008875_abnormal_xenobiotic_pharmacok5.09366932
6MP0003806_abnormal_nucleotide_metabolis4.34689735
7MP0003252_abnormal_bile_duct3.83533763
8MP0010329_abnormal_lipoprotein_level3.58838447
9MP0009840_abnormal_foam_cell3.22825515
10MP0005083_abnormal_biliary_tract3.05342225
11MP0003195_calcinosis2.79771181
12MP0005332_abnormal_amino_acid2.67568063
13MP0001666_abnormal_nutrient_absorption2.54762648
14MP0003191_abnormal_cellular_cholesterol2.38423146
15MP0000609_abnormal_liver_physiology2.18759381
16MP0002118_abnormal_lipid_homeostasis2.07832381
17MP0004019_abnormal_vitamin_homeostasis2.05458018
18MP0003868_abnormal_feces_composition2.00646014
19MP0002138_abnormal_hepatobiliary_system1.96098711
20MP0005319_abnormal_enzyme/_coenzyme1.87309986
21MP0001764_abnormal_homeostasis1.79597467
22MP0005397_hematopoietic_system_phenotyp1.76322391
23MP0001545_abnormal_hematopoietic_system1.76322391
24MP0003656_abnormal_erythrocyte_physiolo1.73261092
25MP0009697_abnormal_copulation1.71250655
26MP0005584_abnormal_enzyme/coenzyme_acti1.60084252
27MP0003186_abnormal_redox_activity1.43060303
28MP0003011_delayed_dark_adaptation1.40654278
29MP0005451_abnormal_body_composition1.29366042
30MP0000598_abnormal_liver_morphology1.24110470
31MP0009643_abnormal_urine_homeostasis1.20826525
32MP0005647_abnormal_sex_gland1.19779192
33MP0009764_decreased_sensitivity_to1.18334426
34MP0002254_reproductive_system_inflammat1.12115602
35MP0009763_increased_sensitivity_to1.08237877
36MP0010368_abnormal_lymphatic_system1.02747669
37MP0005636_abnormal_mineral_homeostasis1.02652192
38MP0008469_abnormal_protein_level1.00080149
39MP0000604_amyloidosis0.97814530
40MP0006036_abnormal_mitochondrial_physio0.95062427
41MP0009642_abnormal_blood_homeostasis0.90328815
42MP0009765_abnormal_xenobiotic_induced0.85776236
43MP0005376_homeostasis/metabolism_phenot0.83259387
44MP0003705_abnormal_hypodermis_morpholog0.83096818
45MP0005084_abnormal_gallbladder_morpholo0.82460077
46MP0000566_synostosis0.82238314
47MP0002876_abnormal_thyroid_physiology0.80406842
48MP0005670_abnormal_white_adipose0.79610647
49MP0005464_abnormal_platelet_physiology0.77297741
50MP0006292_abnormal_olfactory_placode0.76378891
51MP0005220_abnormal_exocrine_pancreas0.75550019
52MP0002078_abnormal_glucose_homeostasis0.75341204
53MP0005408_hypopigmentation0.75119605
54MP0003724_increased_susceptibility_to0.74753835
55MP0005334_abnormal_fat_pad0.69394914
56MP0002971_abnormal_brown_adipose0.68069068
57MP0006035_abnormal_mitochondrial_morpho0.67389427
58MP0005535_abnormal_body_temperature0.67056760
59MP0004130_abnormal_muscle_cell0.66659953
60MP0005266_abnormal_metabolism0.66147566
61MP0001915_intracranial_hemorrhage0.64963115
62MP0002282_abnormal_trachea_morphology0.64265430
63MP0003172_abnormal_lysosome_physiology0.63113688
64MP0003879_abnormal_hair_cell0.59437689
65MP0003436_decreased_susceptibility_to0.58228966
66MP0004147_increased_porphyrin_level0.58006963
67MP0005646_abnormal_pituitary_gland0.57444268
68MP0000639_abnormal_adrenal_gland0.56765569
69MP0001661_extended_life_span0.56324942
70MP0003690_abnormal_glial_cell0.54469683
71MP0005448_abnormal_energy_balance0.53781471
72MP0002132_abnormal_respiratory_system0.53553965
73MP0002249_abnormal_larynx_morphology0.52512036
74MP0005410_abnormal_fertilization0.52502223
75MP0008995_early_reproductive_senescence0.51222310
76MP0001853_heart_inflammation0.51108025
77MP0003638_abnormal_response/metabolism_0.50876417
78MP0001756_abnormal_urination0.50793481
79MP0009053_abnormal_anal_canal0.50735192
80MP0004145_abnormal_muscle_electrophysio0.49362604
81MP0001986_abnormal_taste_sensitivity0.48612405
82MP0003718_maternal_effect0.48195739
83MP0008873_increased_physiological_sensi0.48093606
84MP0003122_maternal_imprinting0.47813400
85MP0003329_amyloid_beta_deposits0.44848397
86MP0008874_decreased_physiological_sensi0.44739333
87MP0002928_abnormal_bile_duct0.43761369
88MP0002136_abnormal_kidney_physiology0.43711804
89MP0005395_other_phenotype0.43300324
90MP0004782_abnormal_surfactant_physiolog0.42661230
91MP0008872_abnormal_physiological_respon0.42475530
92MP0005058_abnormal_lysosome_morphology0.42333690
93MP0003075_altered_response_to0.41977098
94MP0002089_abnormal_postnatal_growth/wei0.41629897
95MP0005166_decreased_susceptibility_to0.40342910
96MP0003953_abnormal_hormone_level0.39843160
97MP0002168_other_aberrant_phenotype0.39584335
98MP0004381_abnormal_hair_follicle0.39405594
99MP0008775_abnormal_heart_ventricle0.39162069
100MP0002396_abnormal_hematopoietic_system0.39018160
101MP0002822_catalepsy0.38843466
102MP0001845_abnormal_inflammatory_respons0.38527683
103MP0005167_abnormal_blood-brain_barrier0.37908731
104MP0006082_CNS_inflammation0.37727959
105MP0005075_abnormal_melanosome_morpholog0.36874300
106MP0009333_abnormal_splenocyte_physiolog0.36659431
107MP0003699_abnormal_female_reproductive0.34502359
108MP0002970_abnormal_white_adipose0.34168337
109MP0005187_abnormal_penis_morphology0.33319549
110MP0009115_abnormal_fat_cell0.32133348
111MP0000249_abnormal_blood_vessel0.32017136
112MP0009785_altered_susceptibility_to0.31611491
113MP0001243_abnormal_dermal_layer0.31610924
114MP0009672_abnormal_birth_weight0.30341444
115MP0005666_abnormal_adipose_tissue0.30252199
116MP0000678_abnormal_parathyroid_gland0.29789097
117MP0000230_abnormal_systemic_arterial0.29725984
118MP0003111_abnormal_nucleus_morphology0.29553110
119MP0009379_abnormal_foot_pigmentation0.29313579
120MP0004883_abnormal_blood_vessel0.29074000
121MP0005248_abnormal_Harderian_gland0.29015458
122MP0001881_abnormal_mammary_gland0.28546528
123MP0000689_abnormal_spleen_morphology0.27980891
124MP0001529_abnormal_vocalization0.27707783
125MP0008058_abnormal_DNA_repair0.27103651
126MP0000579_abnormal_nail_morphology0.25994061
127MP0005164_abnormal_response_to0.25621868
128MP0005025_abnormal_response_to0.25400902
129MP0002135_abnormal_kidney_morphology0.23513058

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.43647104
2Intrahepatic cholestasis (HP:0001406)7.25735615
3Deep venous thrombosis (HP:0002625)7.25449440
4Prolonged partial thromboplastin time (HP:0003645)6.69804232
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.63059184
6Hypobetalipoproteinemia (HP:0003563)6.33460560
7Xanthomatosis (HP:0000991)6.14793846
8Hyperlipoproteinemia (HP:0010980)5.58204036
9Complement deficiency (HP:0004431)5.37946290
10Joint hemorrhage (HP:0005261)4.94682808
11Hypolipoproteinemia (HP:0010981)4.69827326
12Hyperammonemia (HP:0001987)4.56128654
13Abnormality of the common coagulation pathway (HP:0010990)4.53159411
14Epidermoid cyst (HP:0200040)4.43054287
15Abnormality of methionine metabolism (HP:0010901)4.33867039
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.33532285
17Hyperglycinemia (HP:0002154)4.27759958
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.20332822
19Ketosis (HP:0001946)4.15925806
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11229080
21Hypoalphalipoproteinemia (HP:0003233)4.08596901
22Fat malabsorption (HP:0002630)4.07483941
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.98346448
24Abnormality of pyrimidine metabolism (HP:0004353)3.95060518
25Abnormality of complement system (HP:0005339)3.91890421
26Abnormality of the intrinsic pathway (HP:0010989)3.87708152
27Hypoglycemic coma (HP:0001325)3.78305912
28Hyperglycinuria (HP:0003108)3.75086811
29Conjugated hyperbilirubinemia (HP:0002908)3.74848121
30Abnormality of serine family amino acid metabolism (HP:0010894)3.73687975
31Abnormality of glycine metabolism (HP:0010895)3.73687975
32Hypercholesterolemia (HP:0003124)3.61262672
33Hyperbilirubinemia (HP:0002904)3.59547621
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45413781
35Abnormality of fatty-acid metabolism (HP:0004359)3.38899488
36Spontaneous abortion (HP:0005268)3.29030816
37Delayed CNS myelination (HP:0002188)3.11253839
38Steatorrhea (HP:0002570)3.10249832
39Hypochromic microcytic anemia (HP:0004840)3.09991627
40Abnormality of serum amino acid levels (HP:0003112)3.07735060
41Abnormality of nucleobase metabolism (HP:0010932)3.03784646
42Hepatocellular carcinoma (HP:0001402)3.01369351
43Abnormality of reticulocytes (HP:0004312)2.96188108
44Acanthocytosis (HP:0001927)2.93424926
45Cerebral palsy (HP:0100021)2.90658874
46Myocardial infarction (HP:0001658)2.85990155
47Polycythemia (HP:0001901)2.85493261
48Ketoacidosis (HP:0001993)2.85398756
49Purpura (HP:0000979)2.84496404
50Metabolic acidosis (HP:0001942)2.80136441
51Systemic lupus erythematosus (HP:0002725)2.72843452
52Dicarboxylic aciduria (HP:0003215)2.64414002
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64414002
54Skin nodule (HP:0200036)2.64301587
55Lethargy (HP:0001254)2.60094227
56Abnormality of purine metabolism (HP:0004352)2.58146710
57Gingival bleeding (HP:0000225)2.54137205
58Abnormal gallbladder morphology (HP:0012437)2.48481594
59Osteomalacia (HP:0002749)2.46978983
60Glomerulonephritis (HP:0000099)2.45657204
61Cholelithiasis (HP:0001081)2.44347552
62Vascular calcification (HP:0004934)2.43467163
63Recurrent gram-negative bacterial infections (HP:0005420)2.43311963
64Spastic diplegia (HP:0001264)2.43237262
65Cerebral edema (HP:0002181)2.42912310
66Poikilocytosis (HP:0004447)2.41507150
67Cholecystitis (HP:0001082)2.40892204
68Abnormal gallbladder physiology (HP:0012438)2.40892204
69Hypoglycemic seizures (HP:0002173)2.38333832
70Mitral stenosis (HP:0001718)2.33121095
71Thrombophlebitis (HP:0004418)2.32189280
72Amyloidosis (HP:0011034)2.31391942
73Abnormal platelet function (HP:0011869)2.30675220
74Impaired platelet aggregation (HP:0003540)2.30675220
75Gout (HP:0001997)2.30465594
76Menorrhagia (HP:0000132)2.30327035
77Irritability (HP:0000737)2.30172041
78Neonatal onset (HP:0003623)2.28689979
79Brushfield spots (HP:0001088)2.25158833
80Prolonged bleeding time (HP:0003010)2.24439342
81Pancreatitis (HP:0001733)2.17376505
82Opisthotonus (HP:0002179)2.17168297
83Generalized aminoaciduria (HP:0002909)2.16885845
84Increased serum pyruvate (HP:0003542)2.15724872
85Cardiovascular calcification (HP:0011915)2.12922539
86Late onset (HP:0003584)2.11412019
87Esophageal varix (HP:0002040)2.11194748
88Malnutrition (HP:0004395)2.08934947
89Vomiting (HP:0002013)2.07075694
90Enlarged kidneys (HP:0000105)2.05604133
91Sensorimotor neuropathy (HP:0007141)2.02506685
92Abnormality of the gallbladder (HP:0005264)2.01756766
93Fair hair (HP:0002286)1.98426626
94* Abnormality of transition element cation homeostasis (HP:0011030)1.97580302
95Renal cortical cysts (HP:0000803)1.97090614
96Hemorrhage of the eye (HP:0011885)1.96623450
97Hypochromic anemia (HP:0001931)1.95168529
98Reduced antithrombin III activity (HP:0001976)1.93598392
99Abnormality of glycolysis (HP:0004366)1.93278504
100* Abnormality of iron homeostasis (HP:0011031)1.91731566
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.87315020
102Reticulocytosis (HP:0001923)1.87310011
103Joint swelling (HP:0001386)1.87090338
104* Elevated hepatic transaminases (HP:0002910)1.84875083
105Hyperinsulinemic hypoglycemia (HP:0000825)1.84143071
106Rickets (HP:0002748)1.83037013
107Spastic paraparesis (HP:0002313)1.79973058
108Increased mean platelet volume (HP:0011877)1.78985703
109Epistaxis (HP:0000421)1.78251489
110Abnormal cartilage morphology (HP:0002763)1.77996282
111Arthropathy (HP:0003040)1.77317131
112Abnormality of urine glucose concentration (HP:0011016)1.76998526
113Glycosuria (HP:0003076)1.76998526
114Pulmonary embolism (HP:0002204)1.76020932
115Abnormal enzyme/coenzyme activity (HP:0012379)1.74760991
116Alkalosis (HP:0001948)1.74385133
117Abnormal number of erythroid precursors (HP:0012131)1.73382998
118Hypertriglyceridemia (HP:0002155)1.73132761
119Hyperphosphaturia (HP:0003109)1.71100921
120Hypophosphatemic rickets (HP:0004912)1.71087556
121Nephritis (HP:0000123)1.70571997
122Seborrheic dermatitis (HP:0001051)1.69314150
123Hydroxyprolinuria (HP:0003080)1.68367959
124Abnormality of proline metabolism (HP:0010907)1.68367959
125Neoplasm of the liver (HP:0002896)1.65340675
126Elevated alkaline phosphatase (HP:0003155)1.61348781
127Abnormal platelet volume (HP:0011876)1.60866371
128Neonatal hypoglycemia (HP:0001998)1.59125733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.22142946
2EIF2AK14.74967861
3FGFR44.38831465
4ERN14.25244431
5SIK14.13961764
6TAOK33.31363927
7MAP4K23.01150035
8PIM22.92834420
9INSRR2.91715043
10ERBB42.82798169
11FLT32.23809652
12MAP2K42.18416495
13MST1R2.08378951
14NUAK12.04058106
15VRK22.02944079
16MAPK112.02560194
17RAF11.97593188
18PKN21.94316723
19PIK3CG1.91644345
20TYK21.89241510
21NTRK31.80435081
22SCYL21.78266349
23PRPF4B1.75711989
24WNK41.70546828
25KDR1.64072679
26TIE11.56384216
27MAP2K31.55717524
28ABL21.47593576
29BUB11.46084955
30NEK91.42086617
31PINK11.40520655
32JAK21.37502450
33TBK11.37429306
34TRIB31.35492328
35DAPK21.30135603
36PIK3CA1.23082553
37SIK21.22829153
38MAPK41.20956531
39MAP3K71.18188813
40BRSK21.18076064
41KIT1.14971845
42STK161.13116285
43PTK61.12687838
44PRKAA21.07196033
45MAP3K141.05513583
46LATS11.01933830
47PLK41.01041878
48GRK61.00463695
49MAP3K110.99938295
50IRAK30.99229235
51JAK10.98952764
52NEK20.98539147
53ZAK0.98247328
54TESK20.97798314
55PIM10.96975628
56ERBB20.96191312
57MAP3K30.92813973
58MAP3K100.90880451
59MAPK150.90347946
60MAP3K10.89935288
61MAPKAPK50.88972152
62TGFBR20.87744481
63IKBKE0.87688507
64CSF1R0.87211979
65NEK10.85385895
66MAPK120.85125055
67MAP2K60.84438154
68CSNK2A10.81420429
69TNK20.81281763
70CCNB10.80795028
71TTK0.80323913
72FRK0.79935153
73JAK30.78546723
74SMG10.77614531
75CSNK2A20.77528627
76ATR0.76070894
77PRKCZ0.74853181
78NME20.74517929
79CDK60.74120073
80FGFR20.72506371
81BTK0.71606731
82MAP4K10.69941113
83TEC0.68267801
84PRKACG0.67871877
85CDK70.66562469
86RPS6KA50.65604911
87DYRK20.64982773
88ACVR1B0.64727117
89CDC70.64073522
90PRKACA0.63373425
91VRK10.63107399
92GRK10.63059121
93RIPK40.62644502
94WNK10.62142624
95RET0.61120614
96EPHA30.60911125
97CAMK2G0.59307297
98CLK10.59276266
99CSNK1E0.58792539
100CSNK1G10.57881946
101EEF2K0.57271743
102CDK40.57228449
103ATM0.57024103
104BRSK10.55872539
105MAPK70.55579743
106SGK30.53865953
107CSK0.53732580
108DAPK10.53673239
109TLK10.52465478
110PRKAA10.52364262
111NME10.52110058
112AURKA0.51767445
113DYRK1B0.51420751
114PLK10.50759186
115CDK20.50683503
116BMX0.49774402
117TGFBR10.49197438
118ADRBK20.48635610
119GSK3A0.48532433
120RPS6KA30.46768759
121TAOK20.46726556
122SGK20.46556293
123MAP3K60.45272151
124CAMK1D0.44797791
125CHEK20.44229319
126MET0.44193181
127CDK10.42732402
128CSNK1G30.42466758
129PRKCB0.42192999
130IKBKB0.40653685
131PDK20.40181186
132PRKG10.39562281
133MAP3K50.38617744
134ZAP700.38413314
135FGFR30.37976040
136PDPK10.37689725
137EPHB10.37569569
138LYN0.37493913
139STK38L0.37449258
140IGF1R0.36764683
141PRKCQ0.36325181
142CAMK40.34474192
143SYK0.33366850
144RIPK10.32876473
145MAPK30.30942987
146BLK0.29478730
147CSNK1G20.29443962
148MAP2K20.28752753
149MAP2K10.28035476
150EGFR0.27668757
151PRKCG0.27401303
152IRAK10.26867067
153CHUK0.26086392
154PDK10.25954874
155ICK0.25797391
156RPS6KB10.23288672
157ABL10.23036429
158MATK0.22782291

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.59148215
2Nitrogen metabolism_Homo sapiens_hsa009103.49056813
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30902704
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28946570
5Arginine biosynthesis_Homo sapiens_hsa002203.02318078
6Complement and coagulation cascades_Homo sapiens_hsa046102.85660047
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68186043
8Tryptophan metabolism_Homo sapiens_hsa003802.67041838
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61031839
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56277446
11Fatty acid degradation_Homo sapiens_hsa000712.49943601
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36304669
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27161027
14Peroxisome_Homo sapiens_hsa041462.11623324
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09492883
16Butanoate metabolism_Homo sapiens_hsa006502.08465272
17Chemical carcinogenesis_Homo sapiens_hsa052041.93150560
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.91835103
19Histidine metabolism_Homo sapiens_hsa003401.90131579
20Propanoate metabolism_Homo sapiens_hsa006401.89100945
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89053365
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.86430846
23PPAR signaling pathway_Homo sapiens_hsa033201.83575716
24Staphylococcus aureus infection_Homo sapiens_hsa051501.81709763
25Caffeine metabolism_Homo sapiens_hsa002321.78928860
26Fatty acid metabolism_Homo sapiens_hsa012121.76163924
27beta-Alanine metabolism_Homo sapiens_hsa004101.72705319
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72040904
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71550850
30Selenocompound metabolism_Homo sapiens_hsa004501.70446997
31Retinol metabolism_Homo sapiens_hsa008301.69731079
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64101946
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54277705
34Phenylalanine metabolism_Homo sapiens_hsa003601.51749701
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51626727
36Bile secretion_Homo sapiens_hsa049761.43125312
37Tyrosine metabolism_Homo sapiens_hsa003501.41866561
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.41329369
39Folate biosynthesis_Homo sapiens_hsa007901.34138554
40Pyruvate metabolism_Homo sapiens_hsa006201.33560693
41Fatty acid elongation_Homo sapiens_hsa000621.32915792
42Sulfur metabolism_Homo sapiens_hsa009201.29584090
43Starch and sucrose metabolism_Homo sapiens_hsa005001.26764349
44ABC transporters_Homo sapiens_hsa020101.26698590
45Biosynthesis of amino acids_Homo sapiens_hsa012301.22278032
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17630603
47Steroid biosynthesis_Homo sapiens_hsa001001.12722630
48Carbon metabolism_Homo sapiens_hsa012001.12318659
49Fat digestion and absorption_Homo sapiens_hsa049751.11223985
50Sulfur relay system_Homo sapiens_hsa041221.07529865
51Vitamin B6 metabolism_Homo sapiens_hsa007501.04183156
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02337599
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.01497172
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99674094
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.98317044
56Arginine and proline metabolism_Homo sapiens_hsa003300.92808065
57One carbon pool by folate_Homo sapiens_hsa006700.90131947
58Vitamin digestion and absorption_Homo sapiens_hsa049770.88138784
59Lysine degradation_Homo sapiens_hsa003100.77733467
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77195201
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67805902
62Glutathione metabolism_Homo sapiens_hsa004800.65151031
63Pentose phosphate pathway_Homo sapiens_hsa000300.64950771
64Glycerolipid metabolism_Homo sapiens_hsa005610.62431024
65Metabolic pathways_Homo sapiens_hsa011000.50218877
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48511548
67Fatty acid biosynthesis_Homo sapiens_hsa000610.44432975
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37242475
69Prion diseases_Homo sapiens_hsa050200.30847552
70Galactose metabolism_Homo sapiens_hsa000520.30004657
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25746963
72Fructose and mannose metabolism_Homo sapiens_hsa000510.24061413
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23571602
74Linoleic acid metabolism_Homo sapiens_hsa005910.22153727
75Insulin resistance_Homo sapiens_hsa049310.19738480
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.19292913
77Other glycan degradation_Homo sapiens_hsa005110.13098453
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.12849508
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10070800
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.04389035
81Glucagon signaling pathway_Homo sapiens_hsa049220.03933877
82Base excision repair_Homo sapiens_hsa034100.03836686
83DNA replication_Homo sapiens_hsa030300.02526859
84N-Glycan biosynthesis_Homo sapiens_hsa005100.00924648
85Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2627099
86Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2545891
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2277245
88Pertussis_Homo sapiens_hsa05133-0.2232925
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2200696
90Renin-angiotensin system_Homo sapiens_hsa04614-0.1922415
91Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1834375
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1807246
93Hepatitis C_Homo sapiens_hsa05160-0.1673529
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1634992
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1573838
96African trypanosomiasis_Homo sapiens_hsa05143-0.1425204
97Insulin signaling pathway_Homo sapiens_hsa04910-0.1363736
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1253997
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1164957
100Mismatch repair_Homo sapiens_hsa03430-0.1159506
101Pyrimidine metabolism_Homo sapiens_hsa00240-0.1130037
102Regulation of autophagy_Homo sapiens_hsa04140-0.1088312
103Mineral absorption_Homo sapiens_hsa04978-0.0982465
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0940858
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.0824392
106Homologous recombination_Homo sapiens_hsa03440-0.0765490
107Fanconi anemia pathway_Homo sapiens_hsa03460-0.0635861
108Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0370084
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0233047
110AMPK signaling pathway_Homo sapiens_hsa04152-0.0225354
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0148605

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