TG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to lead ion (GO:0010288)9.20227095
2sulfate transmembrane transport (GO:1902358)8.92643907
3regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)8.81843800
4regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033398.40447888
5* thyroid gland development (GO:0030878)7.68881733
6nephron tubule formation (GO:0072079)7.66783767
7negative regulation of metanephros development (GO:0072217)7.47159113
8positive regulation of glycogen biosynthetic process (GO:0045725)7.40175616
9sulfate transport (GO:0008272)7.35580504
10phosphorelay signal transduction system (GO:0000160)7.18867892
11regulation of apoptotic process involved in morphogenesis (GO:1902337)7.10740995
12pattern specification involved in kidney development (GO:0061004)6.88024232
13hydrogen peroxide catabolic process (GO:0042744)6.83866877
14positive regulation of glycogen metabolic process (GO:0070875)6.39006587
15bicarbonate transport (GO:0015701)6.04890111
16urogenital system development (GO:0001655)5.87603475
17negative regulation of microtubule polymerization (GO:0031115)5.74000018
18metanephric nephron tubule development (GO:0072234)5.72482629
19metanephric tubule development (GO:0072170)5.72482629
20regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.66058716
21bone resorption (GO:0045453)5.55563873
22mesonephros development (GO:0001823)5.52567185
23positive regulation of cellular amine metabolic process (GO:0033240)5.45020936
24metanephric nephron epithelium development (GO:0072243)5.24712146
25regulation of epithelial cell differentiation involved in kidney development (GO:2000696)5.07906038
26* phenol-containing compound metabolic process (GO:0018958)5.02456782
27regulation of mesenchymal cell apoptotic process (GO:2001053)4.83132939
28metanephric epithelium development (GO:0072207)4.80488968
29positive regulation of extracellular matrix organization (GO:1903055)4.73569284
30embryonic hemopoiesis (GO:0035162)4.71060654
31mesenchymal to epithelial transition (GO:0060231)4.68860666
32response to vitamin D (GO:0033280)4.67819114
33regulation of stem cell maintenance (GO:2000036)4.65254639
34positive regulation of metanephros development (GO:0072216)4.52297318
35specification of organ identity (GO:0010092)4.40851168
36negative regulation of kidney development (GO:0090185)4.38995894
37mitochondrion distribution (GO:0048311)4.06439137
38hydrogen peroxide metabolic process (GO:0042743)4.02548871
39negative regulation of hormone metabolic process (GO:0032351)4.01103660
40negative regulation of hormone biosynthetic process (GO:0032353)4.01103660
41* thyroid hormone generation (GO:0006590)32.9341238
42positive regulation of glucose import (GO:0046326)3.94311738
43regulation of extracellular matrix disassembly (GO:0010715)3.93548376
44sodium ion export (GO:0071436)3.90232433
45regulation of glucan biosynthetic process (GO:0010962)3.89756561
46regulation of glycogen biosynthetic process (GO:0005979)3.89756561
47positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.78601274
48hemidesmosome assembly (GO:0031581)3.75803708
49regulation of p38MAPK cascade (GO:1900744)3.72545714
50regulation of glucocorticoid metabolic process (GO:0031943)3.70568650
51positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.69496419
52cellular potassium ion homeostasis (GO:0030007)3.68911608
53cerebral cortex neuron differentiation (GO:0021895)3.60719357
54female gonad development (GO:0008585)3.59553148
55atrioventricular valve morphogenesis (GO:0003181)3.58549874
56negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.49199997
57hair follicle morphogenesis (GO:0031069)3.46740499
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.42415896
59sulfur compound transport (GO:0072348)3.38914558
60response to cadmium ion (GO:0046686)3.38816028
61positive regulation of osteoblast proliferation (GO:0033690)3.37979110
62phosphatidylinositol dephosphorylation (GO:0046856)3.34879211
63regulation of polysaccharide biosynthetic process (GO:0032885)3.31670927
64regulation of plasminogen activation (GO:0010755)3.30728245
65surfactant homeostasis (GO:0043129)3.29672866
66skin morphogenesis (GO:0043589)3.29201812
67nephron tubule development (GO:0072080)3.28236426
68positive regulation of glucose transport (GO:0010828)3.26802345
69regulation of Rap GTPase activity (GO:0032317)3.25866119
70phospholipid dephosphorylation (GO:0046839)3.22654237
71keratan sulfate catabolic process (GO:0042340)3.22511907
72pericardium development (GO:0060039)3.21057048
73* hormone biosynthetic process (GO:0042446)3.18802139
74forebrain neuron differentiation (GO:0021879)3.17461284
75regulation of glycogen metabolic process (GO:0070873)3.15309138
76protein retention in ER lumen (GO:0006621)3.12990370
77positive regulation of glucose metabolic process (GO:0010907)3.11022740
78endothelial cell chemotaxis (GO:0035767)3.09635949
79positive regulation of mesonephros development (GO:0061213)3.06639555
80Leydig cell differentiation (GO:0033327)3.03238980
81renal tubule development (GO:0061326)3.02756115
82cellular response to gonadotropin stimulus (GO:0071371)3.02599150
83regulation of extracellular matrix organization (GO:1903053)3.01840236
84* thyroid hormone metabolic process (GO:0042403)26.2301501
85regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.98123984
86membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90502254
87mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.89780249
88Rho protein signal transduction (GO:0007266)2.88319278
89G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.87338986
90peptide catabolic process (GO:0043171)2.86945092
91regulation of metanephros development (GO:0072215)2.85946691
92iron ion import (GO:0097286)2.85906233
93positive regulation of multicellular organism growth (GO:0040018)2.84072903
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.81317060
95epithelial cell morphogenesis (GO:0003382)2.78517393
96regulation of polysaccharide metabolic process (GO:0032881)2.77103462
97positive regulation of Rap GTPase activity (GO:0032854)2.75464397
98* hormone metabolic process (GO:0042445)2.73794634
99positive regulation of bone mineralization (GO:0030501)2.70663237
100negative regulation of stem cell differentiation (GO:2000737)2.68830632
101lung secretory cell differentiation (GO:0061140)2.67923646
102nephron epithelium development (GO:0072009)2.67124163
103sodium ion homeostasis (GO:0055078)2.64825290
104cAMP metabolic process (GO:0046058)2.61689728
105regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.60889086
106regulation of water loss via skin (GO:0033561)2.60749783
107icosanoid secretion (GO:0032309)2.59092164
108arachidonic acid secretion (GO:0050482)2.59092164
109potassium ion export (GO:0071435)2.58900577
110hypotonic response (GO:0006971)2.57787647
111atrial cardiac muscle cell action potential (GO:0086014)2.56366605
112branching involved in ureteric bud morphogenesis (GO:0001658)2.55608795
113positive regulation of p38MAPK cascade (GO:1900745)2.54914730
114icosanoid transport (GO:0071715)2.54386755
115fatty acid derivative transport (GO:1901571)2.54386755
116regulation of mesonephros development (GO:0061217)2.53888910
117membrane repolarization during action potential (GO:0086011)2.53680451
118angiogenesis involved in wound healing (GO:0060055)2.53247056
119positive regulation of digestive system process (GO:0060456)2.52341007
120cellular sodium ion homeostasis (GO:0006883)2.52176056
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51220188
122positive regulation of biomineral tissue development (GO:0070169)2.50995884
123chemical homeostasis within a tissue (GO:0048875)2.48917610
124cellular response to epinephrine stimulus (GO:0071872)2.46840858
125regulation of microtubule polymerization (GO:0031113)2.46256615
126acid secretion (GO:0046717)2.45397418
127* cellular modified amino acid metabolic process (GO:0006575)2.42184745
128adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.40243024
129negative regulation of fatty acid transport (GO:2000192)2.39800236
130negative regulation of epithelial to mesenchymal transition (GO:0010719)2.37304056
131regulation of steroid hormone biosynthetic process (GO:0090030)2.36694842
132response to gonadotropin (GO:0034698)2.35768187
133positive regulation of astrocyte differentiation (GO:0048711)2.35739399
134thymus development (GO:0048538)2.33027575
135regulation of endothelial cell chemotaxis (GO:2001026)2.32662849
136regulation of lipoprotein metabolic process (GO:0050746)2.31969594
137regulation of hormone biosynthetic process (GO:0046885)2.31571544
138embryonic epithelial tube formation (GO:0001838)2.31139038
139membrane repolarization (GO:0086009)2.29653865
140relaxation of cardiac muscle (GO:0055119)2.29455343
141epithelial tube branching involved in lung morphogenesis (GO:0060441)2.29299022
142positive regulation of vascular permeability (GO:0043117)2.28948669
143carnitine metabolic process (GO:0009437)2.28863946
144response to epinephrine (GO:0071871)2.28128772
145negative regulation of bone resorption (GO:0045779)2.27373595
146primitive streak formation (GO:0090009)2.26731595
147response to hydroperoxide (GO:0033194)2.26580531
148ventricular cardiac muscle cell action potential (GO:0086005)2.26255098
149coronary vasculature morphogenesis (GO:0060977)2.25210450
150cellular response to cAMP (GO:0071320)2.23924150
151regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.20858886
152epithelial tube formation (GO:0072175)2.20407179
153positive regulation of histone deacetylation (GO:0031065)2.20379691
154positive regulation of protein kinase C signaling (GO:0090037)2.20059000
155potassium ion import (GO:0010107)2.19272459
156positive regulation of hormone metabolic process (GO:0032352)2.17833728
157regulation of apoptotic cell clearance (GO:2000425)2.17682007
158cardiovascular system development (GO:0072358)2.17447666
159lactate metabolic process (GO:0006089)2.17425737
160lung vasculature development (GO:0060426)2.16533178
161positive regulation of endothelial cell apoptotic process (GO:2000353)2.14790778
162dopaminergic neuron differentiation (GO:0071542)2.12915841
163cortical cytoskeleton organization (GO:0030865)2.11840328
164regulation of hormone metabolic process (GO:0032350)2.10454711
165cell communication by electrical coupling (GO:0010644)2.09268189
166cellular response to hydrogen peroxide (GO:0070301)2.08678428
167regulation of glucose import (GO:0046324)2.01077782
168negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.00370763
169response to parathyroid hormone (GO:0071107)12.8944521
170venous blood vessel morphogenesis (GO:0048845)1.99760910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.21909837
2EZH2_22144423_ChIP-Seq_EOC_Human4.01390033
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.67195992
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.11278170
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.82381712
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58582993
7CLOCK_20551151_ChIP-Seq_293T_Human2.57541030
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.42458088
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.33200515
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.21764714
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20601537
12AR_21572438_ChIP-Seq_LNCaP_Human2.14887940
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.01591147
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.01088752
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.00770634
16KLF5_25053715_ChIP-Seq_YYC3_Human1.98571155
17RACK7_27058665_Chip-Seq_MCF-7_Human1.96379924
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90291978
19SMAD3_21741376_ChIP-Seq_HESCs_Human1.89851967
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86320957
21* EP300_21415370_ChIP-Seq_HL-1_Mouse1.85118869
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82082963
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.81521343
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75996514
25NFIB_24661679_ChIP-Seq_LUNG_Mouse1.74099866
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71436953
27TP53_16413492_ChIP-PET_HCT116_Human1.69847878
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66925602
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64447702
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.63071764
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62324493
32GBX2_23144817_ChIP-Seq_PC3_Human1.61758250
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.58144405
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.55918276
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54484316
36SOX2_20726797_ChIP-Seq_SW620_Human1.54200756
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54067416
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53895506
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.52700610
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52276338
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51230452
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50611607
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.50413512
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49968036
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.48021150
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47675081
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47531647
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.46653569
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44248075
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41403841
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39760519
52LXR_22292898_ChIP-Seq_THP-1_Human1.38667870
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38611962
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36355649
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34720293
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34718381
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34682701
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34298022
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33758435
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32706026
61KDM2B_26808549_Chip-Seq_K562_Human1.32164198
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30320488
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29283872
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29059552
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28145903
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27719257
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27689486
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25811089
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24846056
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23838491
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23439634
72* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23248793
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.22978057
74ISL1_27105846_Chip-Seq_CPCs_Mouse1.22486341
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21702185
76CTCF_27219007_Chip-Seq_Bcells_Human1.21148960
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.19120267
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.19120267
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17439923
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16927627
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.15520158
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15152195
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14749241
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.14572023
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14476211
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.14234982
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14104781
88SMAD4_21741376_ChIP-Seq_HESCs_Human1.13904092
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13179372
90CJUN_26792858_Chip-Seq_BT549_Human1.12925545
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12440681
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12321141
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.12176032
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.12136686
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11737291
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11234574
97BCAT_22108803_ChIP-Seq_LS180_Human1.09439842
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08230587
99* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07912225
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07701947
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07701947
102CTCF_21964334_Chip-Seq_Bcells_Human1.07398027
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07290842
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07002274
105RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06741675
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06741675
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05689026
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05491487
109P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.05380625
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04889080
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.04731520
112SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02952930
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02658539
114RXR_22108803_ChIP-Seq_LS180_Human1.01693551
115GATA1_19941826_ChIP-Seq_K562_Human1.00959443
116TP53_20018659_ChIP-ChIP_R1E_Mouse1.00487161
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00297647
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00104551
119WT1_19549856_ChIP-ChIP_CCG9911_Human0.99805644
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99502481
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98724123
122CREB1_26743006_Chip-Seq_LNCaP_Human0.98110255
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98073044
124SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97857077
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97736981
126KDM2B_26808549_Chip-Seq_DND41_Human0.97441637
127SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97032852
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.97002833
129EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96895683
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96661077
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96340321
132MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.95312702
133P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94967218
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94158776
135TP63_22573176_ChIP-Seq_HFKS_Human0.94040080
136RING1B_27294783_Chip-Seq_NPCs_Mouse0.93804008
137ATF3_27146783_Chip-Seq_COLON_Human0.93618281
138GATA1_22025678_ChIP-Seq_K562_Human0.93476585
139SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92526580
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92314566
141TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91742002
142FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91695239
143STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90631663
144EGR1_19032775_ChIP-ChIP_M12_Human0.90617294
145TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89737202
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88210804
147TCF7_22412390_ChIP-Seq_EML_Mouse0.88143303
148TAF15_26573619_Chip-Seq_HEK293_Human0.86467491
149EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84139768
150CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84063925
151TP53_23651856_ChIP-Seq_MEFs_Mouse0.83845728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000681_abnormal_thyroid_gland8.26577353
2MP0000678_abnormal_parathyroid_gland7.98942450
3MP0000383_abnormal_hair_follicle7.72873861
4MP0010678_abnormal_skin_adnexa6.43676560
5MP0004043_abnormal_pH_regulation5.69585842
6MP0001501_abnormal_sleep_pattern4.00335701
7MP0008004_abnormal_stomach_pH3.43918980
8MP0010368_abnormal_lymphatic_system3.42675197
9MP0002876_abnormal_thyroid_physiology3.20561152
10MP0001485_abnormal_pinna_reflex3.02609820
11MP0004742_abnormal_vestibular_system2.77297220
12MP0004084_abnormal_cardiac_muscle2.43395652
13MP0008569_lethality_at_weaning2.22294182
14MP0010234_abnormal_vibrissa_follicle2.21807281
15MP0003172_abnormal_lysosome_physiology2.06560213
16MP0008995_early_reproductive_senescence1.90358026
17MP0004036_abnormal_muscle_relaxation1.87488171
18MP0009250_abnormal_appendicular_skeleto1.77720756
19MP0003890_abnormal_embryonic-extraembry1.76558837
20MP0002234_abnormal_pharynx_morphology1.73988150
21MP0009780_abnormal_chondrocyte_physiolo1.62895356
22MP0001963_abnormal_hearing_physiology1.60993363
23MP0002896_abnormal_bone_mineralization1.58678697
24MP0000462_abnormal_digestive_system1.57717638
25MP0003868_abnormal_feces_composition1.54720050
26MP0000026_abnormal_inner_ear1.53114586
27MP0003938_abnormal_ear_development1.52015453
28MP0008438_abnormal_cutaneous_collagen1.45461303
29MP0005058_abnormal_lysosome_morphology1.40730681
30MP0005381_digestive/alimentary_phenotyp1.40101155
31MP0003566_abnormal_cell_adhesion1.38531883
32MP0005584_abnormal_enzyme/coenzyme_acti1.35243692
33MP0005508_abnormal_skeleton_morphology1.33786561
34MP0004272_abnormal_basement_membrane1.32460162
35MP0003191_abnormal_cellular_cholesterol1.30430933
36MP0003075_altered_response_to1.29188524
37MP0001663_abnormal_digestive_system1.28443782
38MP0010771_integument_phenotype1.26068770
39MP0009643_abnormal_urine_homeostasis1.25273799
40MP0000566_synostosis1.18605259
41MP0000537_abnormal_urethra_morphology1.17327551
42MP0001756_abnormal_urination1.09112003
43MP0000747_muscle_weakness1.08759952
44MP0003656_abnormal_erythrocyte_physiolo1.02430837
45MP0009053_abnormal_anal_canal0.99123264
46MP0008775_abnormal_heart_ventricle0.98749147
47MP0003879_abnormal_hair_cell0.94099633
48MP0000534_abnormal_ureter_morphology0.93540475
49MP0000631_abnormal_neuroendocrine_gland0.93097424
50MP0005409_darkened_coat_color0.91438920
51MP0003303_peritoneal_inflammation0.88092428
52MP0002796_impaired_skin_barrier0.86274000
53MP0002822_catalepsy0.81691254
54MP0000163_abnormal_cartilage_morphology0.79702188
55MP0005165_increased_susceptibility_to0.79390506
56MP0001879_abnormal_lymphatic_vessel0.79147646
57MP0001958_emphysema0.78000154
58MP0003638_abnormal_response/metabolism_0.74860055
59MP0000049_abnormal_middle_ear0.74436459
60MP0001348_abnormal_lacrimal_gland0.70614683
61MP0002877_abnormal_melanocyte_morpholog0.70282331
62MP0002735_abnormal_chemical_nociception0.69801478
63MP0002089_abnormal_postnatal_growth/wei0.68348927
64MP0005390_skeleton_phenotype0.66214609
65MP0000762_abnormal_tongue_morphology0.65669975
66MP0002098_abnormal_vibrissa_morphology0.65312035
67MP0003329_amyloid_beta_deposits0.64765264
68MP0004782_abnormal_surfactant_physiolog0.64473404
69MP0005166_decreased_susceptibility_to0.63879226
70MP0003795_abnormal_bone_structure0.63340004
71MP0002177_abnormal_outer_ear0.63274286
72MP0002295_abnormal_pulmonary_circulatio0.61890872
73MP0003183_abnormal_peptide_metabolism0.60633240
74MP0003953_abnormal_hormone_level0.60592253
75MP0002060_abnormal_skin_morphology0.59622083
76MP0001849_ear_inflammation0.59265414
77MP0001765_abnormal_ion_homeostasis0.58960252
78MP0008961_abnormal_basal_metabolism0.58870585
79MP0001346_abnormal_lacrimal_gland0.58633267
80MP0004885_abnormal_endolymph0.58372965
81MP0005365_abnormal_bile_salt0.57775140
82MP0005636_abnormal_mineral_homeostasis0.56640897
83MP0002972_abnormal_cardiac_muscle0.56037046
84MP0004185_abnormal_adipocyte_glucose0.55231707
85MP0003755_abnormal_palate_morphology0.54358500
86MP0005023_abnormal_wound_healing0.54098684
87MP0003119_abnormal_digestive_system0.53200755
88MP0004130_abnormal_muscle_cell0.52858277
89MP0008875_abnormal_xenobiotic_pharmacok0.52538850
90MP0001440_abnormal_grooming_behavior0.52531404
91MP0004484_altered_response_of0.52038006
92MP0002136_abnormal_kidney_physiology0.50623912
93MP0002229_neurodegeneration0.50553489
94MP0002168_other_aberrant_phenotype0.49596474
95MP0005377_hearing/vestibular/ear_phenot0.45761526
96MP0003878_abnormal_ear_physiology0.45761526
97MP0001502_abnormal_circadian_rhythm0.45430135
98MP0005319_abnormal_enzyme/_coenzyme0.45189945
99MP0005076_abnormal_cell_differentiation0.44620186
100MP0004134_abnormal_chest_morphology0.44287514
101MP0005647_abnormal_sex_gland0.44234801
102MP0010030_abnormal_orbit_morphology0.43640474
103MP0003935_abnormal_craniofacial_develop0.43634865
104MP0001270_distended_abdomen0.43106937
105MP0002332_abnormal_exercise_endurance0.43010240
106MP0001177_atelectasis0.41360057
107MP0003936_abnormal_reproductive_system0.41337520
108MP0000003_abnormal_adipose_tissue0.40882696
109MP0001851_eye_inflammation0.40864027
110MP0002113_abnormal_skeleton_development0.40166817
111MP0003195_calcinosis0.40023943
112MP0005623_abnormal_meninges_morphology0.39792937
113MP0002282_abnormal_trachea_morphology0.39719660
114MP0006138_congestive_heart_failure0.39653065
115MP0006036_abnormal_mitochondrial_physio0.39641193
116MP0009745_abnormal_behavioral_response0.39460130
117MP0004264_abnormal_extraembryonic_tissu0.39182221
118MP0003115_abnormal_respiratory_system0.38456636
119MP0002063_abnormal_learning/memory/cond0.37437320
120MP0003690_abnormal_glial_cell0.37105454
121MP0005620_abnormal_muscle_contractility0.36634171
122MP0003091_abnormal_cell_migration0.36464729
123MP0002116_abnormal_craniofacial_bone0.36003034
124MP0009642_abnormal_blood_homeostasis0.35924701
125MP0009703_decreased_birth_body0.35707239
126MP0002272_abnormal_nervous_system0.35655138
127MP0005310_abnormal_salivary_gland0.35298191
128MP0000749_muscle_degeneration0.34931076
129MP0001984_abnormal_olfaction0.34922524
130MP0002135_abnormal_kidney_morphology0.34771186
131MP0003705_abnormal_hypodermis_morpholog0.33994203
132MP0000465_gastrointestinal_hemorrhage0.33506726
133MP0003453_abnormal_keratinocyte_physiol0.33121136
134MP0000377_abnormal_hair_follicle0.32400147
135MP0003137_abnormal_impulse_conducting0.29351878
136MP0003942_abnormal_urinary_system0.29224142
137MP0003937_abnormal_limbs/digits/tail_de0.26835398
138MP0000367_abnormal_coat/_hair0.25658395
139MP0005503_abnormal_tendon_morphology0.21645677
140MP0002092_abnormal_eye_morphology0.21509252
141MP0003699_abnormal_female_reproductive0.20384548
142* MP0001731_abnormal_postnatal_growth0.20159534
143MP0002933_joint_inflammation0.20146588
144MP0009278_abnormal_bone_marrow0.20021774
145MP0002998_abnormal_bone_remodeling0.19053639
146MP0003698_abnormal_male_reproductive0.18945272
147MP0005275_abnormal_skin_tensile0.18535284
148MP0002133_abnormal_respiratory_system0.18249739
149MP0005388_respiratory_system_phenotype0.18249739
150MP0005375_adipose_tissue_phenotype0.18236431
151MP0002118_abnormal_lipid_homeostasis0.18194476

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair laboratory examination (HP:0003328)9.33584179
2Congenital sensorineural hearing impairment (HP:0008527)8.98016600
3Tetany (HP:0001281)8.77098805
4Hyperphosphatemia (HP:0002905)7.91143964
5* Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)7.34194231
6Small epiphyses (HP:0010585)7.24785777
7Abnormality of cochlea (HP:0000375)7.21270633
8Hypothermia (HP:0002045)6.50686850
9Morphological abnormality of the inner ear (HP:0011390)5.63780115
10Onycholysis (HP:0001806)5.39859292
11Hypoparathyroidism (HP:0000829)4.97191063
12Delayed epiphyseal ossification (HP:0002663)4.63747988
13Cervical subluxation (HP:0003308)4.32349677
14Irregular epiphyses (HP:0010582)4.19847789
15Mild short stature (HP:0003502)4.06602798
16* Hypothyroidism (HP:0000821)4.05159297
17Mucopolysacchariduria (HP:0008155)3.72963974
18Urinary glycosaminoglycan excretion (HP:0003541)3.72963974
19Ulnar deviation of the wrist (HP:0003049)3.66896991
20Delayed CNS myelination (HP:0002188)3.59250307
21Hyperparathyroidism (HP:0000843)3.56148645
22Epiphyseal dysplasia (HP:0002656)3.55641124
23* Thyroid carcinoma (HP:0002890)3.40425644
24Abnormality of polysaccharide metabolism (HP:0011012)3.38067020
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.38067020
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.38067020
27* Coarse facial features (HP:0000280)3.37683954
28Hyperactive renin-angiotensin system (HP:0000841)3.21512280
29Neonatal respiratory distress (HP:0002643)3.07652970
30Prenatal maternal abnormality (HP:0002686)2.96834123
31Bradycardia (HP:0001662)2.91716355
32Muscle fiber splitting (HP:0003555)2.85409742
33Disproportionate short-trunk short stature (HP:0003521)2.83866611
34Tracheal stenosis (HP:0002777)2.83026916
35Hyperpituitarism (HP:0010514)2.77009999
36Hypoplasia of the odontoid process (HP:0003311)2.71505169
37* Constipation (HP:0002019)2.71243711
38Hoarse voice (HP:0001609)2.66708340
39Hypocalcemia (HP:0002901)2.56620470
40Split foot (HP:0001839)2.53202429
41Ventricular fibrillation (HP:0001663)2.38737268
42Partial duplication of thumb phalanx (HP:0009944)2.36907506
43Abnormality of the odontoid process (HP:0003310)2.26840249
44Accelerated skeletal maturation (HP:0005616)2.24720949
45Chronic bronchitis (HP:0004469)2.19174768
46Broad metatarsal (HP:0001783)2.18929967
47Atrophic scars (HP:0001075)2.11880610
48Partial duplication of the phalanx of hand (HP:0009999)2.09264020
49Ovoid vertebral bodies (HP:0003300)2.05918600
50Fragile nails (HP:0001808)2.05633157
51Upper limb amyotrophy (HP:0009129)2.02290148
52Distal upper limb amyotrophy (HP:0007149)2.02290148
53Difficulty running (HP:0009046)2.01129180
54Pili torti (HP:0003777)14.9534683
55* Goiter (HP:0000853)12.9660746
56Thyroid-stimulating hormone excess (HP:0002925)10.4506199
57Urethral obstruction (HP:0000796)1.99357566
58Bronchomalacia (HP:0002780)1.99284304
59Milia (HP:0001056)1.97688378
60Obstructive sleep apnea (HP:0002870)1.97616536
61Abnormality of the dental pulp (HP:0006479)1.88950605
62Abnormality of the dental root (HP:0006486)1.86399364
63Taurodontia (HP:0000679)1.86399364
64Abnormality of permanent molar morphology (HP:0011071)1.86399364
65Flat acetabular roof (HP:0003180)1.85623609
66Generalized amyotrophy (HP:0003700)1.84554331
67Difficulty climbing stairs (HP:0003551)1.84431854
68Limb-girdle muscle atrophy (HP:0003797)1.83278168
69Lower limb asymmetry (HP:0100559)1.80201483
70Asymmetry of the thorax (HP:0001555)1.77608979
71Abnormal hemoglobin (HP:0011902)1.77408102
72Abnormality of the antihelix (HP:0009738)1.73673518
73Lower limb hyperreflexia (HP:0002395)1.72646141
74Abnormality of molar (HP:0011077)1.72120697
75Abnormality of molar morphology (HP:0011070)1.72120697
76Hand muscle atrophy (HP:0009130)1.71253443
77Stridor (HP:0010307)1.70544936
78Type I diabetes mellitus (HP:0100651)1.69598039
79Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67835466
80Genu varum (HP:0002970)1.65917193
81Abnormality of the distal phalanges of the toes (HP:0010182)1.62385638
82Respiratory distress (HP:0002098)1.60312438
83Nonprogressive disorder (HP:0003680)1.60129199
84Abdominal distention (HP:0003270)1.58556023
85Increased connective tissue (HP:0009025)1.57841788
86Abnormality of chloride homeostasis (HP:0011422)1.57399169
87Aplasia of the musculature (HP:0100854)1.56715637
88Vaginal fistula (HP:0004320)1.55179767
89Right ventricular cardiomyopathy (HP:0011663)1.54409326
90Increased density of long bones (HP:0006392)1.52286778
91Decreased circulating renin level (HP:0003351)1.52223849
92Hyperkalemia (HP:0002153)1.51828969
93Neurofibrillary tangles (HP:0002185)1.49484843
94Distal lower limb muscle weakness (HP:0009053)1.48256248
95Sleep apnea (HP:0010535)1.48245342
96Achilles tendon contracture (HP:0001771)1.48166907
97Abnormality of the vocal cords (HP:0008777)1.48166055
98* Umbilical hernia (HP:0001537)1.46212522
99Back pain (HP:0003418)1.46161925
100Abnormality of the middle phalanges of the toes (HP:0010183)1.44914517
101Renal salt wasting (HP:0000127)1.44475816
102* Neoplasm of the thyroid gland (HP:0100031)1.44393973
103Hyperaldosteronism (HP:0000859)1.44379817
104Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.43699682
105Neonatal hypoglycemia (HP:0001998)1.43525227
106Abnormality of the Achilles tendon (HP:0005109)1.42994623
107Diaphragmatic weakness (HP:0009113)1.42802535
108Laryngomalacia (HP:0001601)1.42769794
109Macroglossia (HP:0000158)1.42031583
110Choanal atresia (HP:0000453)1.40952986
111Bifid scrotum (HP:0000048)1.40531567
112Cerebral inclusion bodies (HP:0100314)1.38840500
113Vertigo (HP:0002321)1.37151026
114Abnormality of the vitreous humor (HP:0004327)1.36022974
115Rectovaginal fistula (HP:0000143)1.35997583
116Rectal fistula (HP:0100590)1.35997583
117Ulnar claw (HP:0001178)1.35337801
118Anxiety (HP:0000739)1.34384251
119Sporadic (HP:0003745)1.33553581
120Thoracolumbar scoliosis (HP:0002944)1.33269363
121Abnormality of renin-angiotensin system (HP:0000847)1.32703769
122Prolonged QT interval (HP:0001657)1.31860782
123Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.30825802
124Abnormality of dental color (HP:0011073)1.30431130
125Spinal muscular atrophy (HP:0007269)1.30292690
126Asymmetric septal hypertrophy (HP:0001670)1.29773805
127Exercise-induced muscle cramps (HP:0003710)1.27844073
128Abnormality of the calf musculature (HP:0001430)1.27767860
129Dysostosis multiplex (HP:0000943)1.27604356
130Striae distensae (HP:0001065)1.27580939
131Hypertensive crisis (HP:0100735)1.27466631
132Hypercortisolism (HP:0001578)1.27370689
133EMG: myopathic abnormalities (HP:0003458)1.27039281
134Hypokalemic alkalosis (HP:0001949)1.26259807
135Thickened helices (HP:0000391)1.26028957
136Hypoplastic nipples (HP:0002557)1.25791831
137Hyperthyroidism (HP:0000836)1.25232106
138Syncope (HP:0001279)1.24999560
139Calf muscle hypertrophy (HP:0008981)1.24980487
140Small for gestational age (HP:0001518)1.24583414
141Adrenal overactivity (HP:0002717)1.24082439
142Proximal amyotrophy (HP:0007126)1.23765461
143Shallow orbits (HP:0000586)1.23518500
144Ulnar bowing (HP:0003031)1.20659999
145Hyperbilirubinemia (HP:0002904)1.19664699
146Humeroradial synostosis (HP:0003041)1.19213380
147Synostosis involving the elbow (HP:0003938)1.19213380
148Germ cell neoplasia (HP:0100728)1.18578294
149Subacute progressive viral hepatitis (HP:0006572)1.15559255
150Hypokinesia (HP:0002375)1.14607253
151Seborrheic dermatitis (HP:0001051)1.13536199
152Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.13269525
153Osteoarthritis (HP:0002758)1.13003848
154Premature birth (HP:0001622)1.10523633
155Atelectasis (HP:0100750)1.10287003
156Abnormal epiphyseal ossification (HP:0010656)1.09428357
157Vascular calcification (HP:0004934)1.06080423
158Amelogenesis imperfecta (HP:0000705)1.05620527
159Dysdiadochokinesis (HP:0002075)1.04369976
160Truncal obesity (HP:0001956)1.03837887
161Glomerulonephritis (HP:0000099)1.03638831
162Cardiovascular calcification (HP:0011915)1.03127506
163Segmental peripheral demyelination/remyelination (HP:0003481)1.02459161
164Abnormality of the axillary hair (HP:0100134)1.01056158
165Abnormality of secondary sexual hair (HP:0009888)1.01056158
166Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)0.97688154
167Short hallux (HP:0010109)0.95672973
168Interstitial pulmonary disease (HP:0006530)0.95084929
169Nephropathy (HP:0000112)0.94789578
170Abnormality of the 2nd finger (HP:0004100)0.94034111
171Upper limb muscle weakness (HP:0003484)0.93103542
172Ventricular arrhythmia (HP:0004308)0.93054611
173Peripheral hypomyelination (HP:0007182)0.92958912
174Labial hypoplasia (HP:0000066)0.92500778
175Truncus arteriosus (HP:0001660)0.90677178
176Acanthosis nigricans (HP:0000956)0.90646493
177Purpura (HP:0000979)0.88345278
178Abnormal EKG (HP:0003115)0.86330691
179Increased circulating renin level (HP:0000848)0.85991302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.82609072
2DMPK4.54445271
3MST1R4.35040003
4DAPK23.78674816
5MST43.53169456
6ERN12.81263541
7FGFR22.69899572
8ERBB32.61807521
9EPHB12.31279966
10LRRK22.22430141
11AKT32.20356824
12PAK42.12038492
13KSR22.08757004
14RIPK12.06017774
15RET2.04410785
16FER1.99365418
17NEK11.99146191
18TRPM71.90625199
19NTRK11.83959664
20SIK11.81420831
21DAPK11.78827459
22PTK61.74452245
23MAP3K21.73647097
24PKN21.73330235
25MYLK1.70798193
26PAK31.65738403
27LMTK21.57813819
28MAP3K31.40404561
29MAP2K21.37724407
30PHKG21.36534164
31PHKG11.36534164
32DAPK31.36340047
33TESK11.35413126
34CDK121.34002800
35MAP2K11.29749739
36BCR1.26514593
37STK241.24076210
38EPHB21.22621719
39TTN1.17247073
40MAP3K91.16181765
41PTK21.16069087
42CAMK1D1.12174617
43MAPK151.11554905
44CLK11.09285650
45EPHA31.05214462
46RPS6KC11.01605811
47RPS6KL11.01605811
48SMG10.99185295
49ILK0.97632234
50BCKDK0.95944040
51CAMK1G0.93748755
52STK100.93044069
53DDR20.91821691
54RPS6KA50.88869653
55FGFR10.87381646
56RPS6KA60.85446230
57PRKCI0.84701980
58EPHA40.84500853
59TBK10.84254411
60JAK10.82675931
61MELK0.80528142
62MATK0.80407005
63NLK0.79159849
64ROCK20.76453369
65MAPKAPK20.76338663
66MAPK120.76153897
67PDK40.75831040
68PDK30.75831040
69PTK2B0.75049054
70RPS6KA20.74882595
71JAK20.72783323
72RPS6KA10.72130042
73PRPF4B0.69384506
74SCYL20.68614700
75FRK0.67486156
76CAMKK20.67463059
77CAMKK10.64696168
78KDR0.64454312
79MARK20.63142150
80MAPK70.62263049
81FGFR40.61824711
82MAP3K70.61339046
83PRKCZ0.60854533
84ERBB20.60048380
85SRC0.57146187
86PRKD10.56608242
87PDGFRA0.56004822
88IRAK30.54501278
89PDPK10.54438761
90EPHA20.53919334
91MAPKAPK30.53895958
92LIMK10.53874302
93TYK20.50980562
94PIK3CA0.50629974
95STK390.50365680
96EEF2K0.48937242
97CSNK1A10.48690178
98MAP3K10.47601126
99STK380.47500551
100FES0.47116525
101BRD40.47022041
102PRKD20.46958354
103EGFR0.44809822
104ADRBK10.44461096
105TYRO30.43979791
106MAP2K60.42519438
107RPS6KB10.42269053
108TGFBR20.42011703
109HCK0.41367042
110MTOR0.41322636
111FYN0.40339360
112HIPK20.40161069
113MAP3K100.39843365
114NEK60.39488587
115TIE10.39145267
116UHMK10.37912887
117MAP3K120.37187919
118ROCK10.36515115
119ITK0.35819175
120PDK10.35722569
121MAP3K80.35426965
122RIPK40.35417417
123LATS20.35034171
124KSR10.34766316
125CDK50.34732882
126MINK10.33751582
127CSK0.33743242
128ARAF0.33546704
129PAK10.33329250
130CSF1R0.33124245
131PINK10.31909266
132FGFR30.31483006
133FGR0.31267528
134INSR0.31219661
135CHUK0.31095781
136CSNK1G20.30937759
137MAPK40.30699122
138LATS10.30206277
139STK30.29953866
140CSNK1A1L0.29864570
141MET0.28990341
142BMX0.28610824
143MAPK80.27716146
144CDK30.26710520
145MAP3K50.26532896
146PRKCG0.21779548
147SGK30.21274521
148PNCK0.20012479
149MAP3K60.19359663
150SGK20.16936389
151NTRK20.14051539
152RPS6KA30.13847128
153PAK20.13666522
154GRK10.13576176
155MAPK90.13425167
156CSNK1D0.12841401

Predicted pathways (KEGG)

RankGene SetZ-score
1* Autoimmune thyroid disease_Homo sapiens_hsa053206.76303020
2* Thyroid hormone synthesis_Homo sapiens_hsa049186.16579289
3Tyrosine metabolism_Homo sapiens_hsa003503.81177211
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.83009002
5Gastric acid secretion_Homo sapiens_hsa049712.55664573
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.52859159
7Sulfur metabolism_Homo sapiens_hsa009202.30122283
8Mineral absorption_Homo sapiens_hsa049782.11619755
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.02972095
10Bile secretion_Homo sapiens_hsa049761.81727169
11Lysosome_Homo sapiens_hsa041421.30367660
12Thyroid cancer_Homo sapiens_hsa052161.24386611
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19929229
14Arginine biosynthesis_Homo sapiens_hsa002201.17237092
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13117854
16ECM-receptor interaction_Homo sapiens_hsa045121.11431893
17Inositol phosphate metabolism_Homo sapiens_hsa005621.08274623
18Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06964857
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06885762
20VEGF signaling pathway_Homo sapiens_hsa043701.05366334
21Bladder cancer_Homo sapiens_hsa052191.04728343
22Amoebiasis_Homo sapiens_hsa051461.03523018
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03070281
24Vibrio cholerae infection_Homo sapiens_hsa051101.00506289
25Histidine metabolism_Homo sapiens_hsa003400.99575652
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93092441
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92128137
28Other glycan degradation_Homo sapiens_hsa005110.89251419
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88989356
30Circadian rhythm_Homo sapiens_hsa047100.86443122
31Small cell lung cancer_Homo sapiens_hsa052220.81221191
32Focal adhesion_Homo sapiens_hsa045100.80326666
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79960756
34TGF-beta signaling pathway_Homo sapiens_hsa043500.79716622
35Tryptophan metabolism_Homo sapiens_hsa003800.78720799
36Central carbon metabolism in cancer_Homo sapiens_hsa052300.78642135
37Renal cell carcinoma_Homo sapiens_hsa052110.77515746
38Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76808473
39Adherens junction_Homo sapiens_hsa045200.75686360
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75388384
41Cocaine addiction_Homo sapiens_hsa050300.74680997
42Salivary secretion_Homo sapiens_hsa049700.74518160
43Fatty acid degradation_Homo sapiens_hsa000710.73845792
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73168350
45Renin secretion_Homo sapiens_hsa049240.73077607
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72758667
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71412004
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70723811
49Pyruvate metabolism_Homo sapiens_hsa006200.70190419
50mTOR signaling pathway_Homo sapiens_hsa041500.70129830
51Endometrial cancer_Homo sapiens_hsa052130.69029236
52Glioma_Homo sapiens_hsa052140.67973640
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.66317386
54Melanogenesis_Homo sapiens_hsa049160.66116441
55Estrogen signaling pathway_Homo sapiens_hsa049150.65751422
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65712492
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65034310
58Proteoglycans in cancer_Homo sapiens_hsa052050.64263461
59Linoleic acid metabolism_Homo sapiens_hsa005910.64203573
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62685141
61Sphingolipid metabolism_Homo sapiens_hsa006000.62518998
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62086522
63Long-term potentiation_Homo sapiens_hsa047200.61543166
64Protein digestion and absorption_Homo sapiens_hsa049740.57827878
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56115264
66Fat digestion and absorption_Homo sapiens_hsa049750.55514460
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55066110
68Antigen processing and presentation_Homo sapiens_hsa046120.53937276
69Collecting duct acid secretion_Homo sapiens_hsa049660.53559905
70Selenocompound metabolism_Homo sapiens_hsa004500.52921427
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51758179
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.51308818
73Nitrogen metabolism_Homo sapiens_hsa009100.50196530
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49777043
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49387150
76Hepatitis C_Homo sapiens_hsa051600.49062180
77Glutathione metabolism_Homo sapiens_hsa004800.48160072
78Tight junction_Homo sapiens_hsa045300.48018581
79Lysine degradation_Homo sapiens_hsa003100.47906129
80Amphetamine addiction_Homo sapiens_hsa050310.46906989
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45903215
82Propanoate metabolism_Homo sapiens_hsa006400.45766358
83Prion diseases_Homo sapiens_hsa050200.45621290
84Glucagon signaling pathway_Homo sapiens_hsa049220.45504908
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.44759327
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44753425
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43404132
88Circadian entrainment_Homo sapiens_hsa047130.42703562
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42675351
90Cardiac muscle contraction_Homo sapiens_hsa042600.40882506
91Insulin resistance_Homo sapiens_hsa049310.40743516
92GnRH signaling pathway_Homo sapiens_hsa049120.40447467
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40263962
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40000468
95Pancreatic secretion_Homo sapiens_hsa049720.39574283
96Toxoplasmosis_Homo sapiens_hsa051450.39504489
97Fructose and mannose metabolism_Homo sapiens_hsa000510.39360765
98Olfactory transduction_Homo sapiens_hsa047400.39348430
99Basal cell carcinoma_Homo sapiens_hsa052170.38972800
100Insulin signaling pathway_Homo sapiens_hsa049100.37926212
101Dopaminergic synapse_Homo sapiens_hsa047280.37824233
102Oxytocin signaling pathway_Homo sapiens_hsa049210.37360632
103Tuberculosis_Homo sapiens_hsa051520.37218097
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36323571
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36043096
106HIF-1 signaling pathway_Homo sapiens_hsa040660.36023062
107cAMP signaling pathway_Homo sapiens_hsa040240.35146363
108Prostate cancer_Homo sapiens_hsa052150.34306451
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33950666
110N-Glycan biosynthesis_Homo sapiens_hsa005100.33464592
111Rap1 signaling pathway_Homo sapiens_hsa040150.33071265
112Hedgehog signaling pathway_Homo sapiens_hsa043400.32986690
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.32278680
114Notch signaling pathway_Homo sapiens_hsa043300.31863951
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31553105
116Hippo signaling pathway_Homo sapiens_hsa043900.31163294
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30963410
118Ras signaling pathway_Homo sapiens_hsa040140.30909868
119Phagosome_Homo sapiens_hsa041450.30787656
120Synaptic vesicle cycle_Homo sapiens_hsa047210.30644700
121Carbon metabolism_Homo sapiens_hsa012000.30077830
122Pathways in cancer_Homo sapiens_hsa052000.29966176
123Pertussis_Homo sapiens_hsa051330.29639795
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29454651
125Butanoate metabolism_Homo sapiens_hsa006500.29220909
126Insulin secretion_Homo sapiens_hsa049110.28986991
127Shigellosis_Homo sapiens_hsa051310.28940806
128Staphylococcus aureus infection_Homo sapiens_hsa051500.28723867
129Glycerolipid metabolism_Homo sapiens_hsa005610.28654652
130beta-Alanine metabolism_Homo sapiens_hsa004100.27815275
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26024985
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.25404666
133Colorectal cancer_Homo sapiens_hsa052100.24984198
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.24575588
135Arachidonic acid metabolism_Homo sapiens_hsa005900.24339142
136Cholinergic synapse_Homo sapiens_hsa047250.24201603
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23977656
138Non-small cell lung cancer_Homo sapiens_hsa052230.23797711
139Arginine and proline metabolism_Homo sapiens_hsa003300.23391499
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22040177
141Acute myeloid leukemia_Homo sapiens_hsa052210.20748086
142Dilated cardiomyopathy_Homo sapiens_hsa054140.20569551
143Osteoclast differentiation_Homo sapiens_hsa043800.20149799
144Apoptosis_Homo sapiens_hsa042100.18388957
145Melanoma_Homo sapiens_hsa052180.17424394
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.16449703
147Chronic myeloid leukemia_Homo sapiens_hsa052200.14490543
148AMPK signaling pathway_Homo sapiens_hsa041520.13108688

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »