TGDS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.59236570
2L-phenylalanine catabolic process (GO:0006559)4.76610575
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.76610575
4L-phenylalanine metabolic process (GO:0006558)4.40419649
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.40419649
6DNA ligation (GO:0006266)4.40023679
7DNA double-strand break processing (GO:0000729)4.33298607
8aromatic amino acid family catabolic process (GO:0009074)4.11326202
9mitotic metaphase plate congression (GO:0007080)4.10321365
10folic acid-containing compound biosynthetic process (GO:0009396)4.08315306
11ribosome assembly (GO:0042255)3.99028236
12tryptophan metabolic process (GO:0006568)3.81014390
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76757545
14respiratory chain complex IV assembly (GO:0008535)3.73725552
15protein neddylation (GO:0045116)3.73623466
16indole-containing compound catabolic process (GO:0042436)3.69253684
17indolalkylamine catabolic process (GO:0046218)3.69253684
18tryptophan catabolic process (GO:0006569)3.69253684
19telomere maintenance via semi-conservative replication (GO:0032201)3.68653911
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64287871
21cullin deneddylation (GO:0010388)3.61617491
22rRNA modification (GO:0000154)3.61503820
23glyoxylate metabolic process (GO:0046487)3.60245397
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56161567
25urea cycle (GO:0000050)3.55038281
26urea metabolic process (GO:0019627)3.55038281
27bile acid biosynthetic process (GO:0006699)3.55036131
28maturation of 5.8S rRNA (GO:0000460)3.49769803
29somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.47001329
30somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.47001329
31isotype switching (GO:0045190)3.47001329
32DNA catabolic process, exonucleolytic (GO:0000738)3.46094613
33replication fork processing (GO:0031297)3.44186434
34histone exchange (GO:0043486)3.42652407
35kynurenine metabolic process (GO:0070189)3.40765649
36cysteine metabolic process (GO:0006534)3.40208498
37metaphase plate congression (GO:0051310)3.39284407
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37328723
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37006600
40negative regulation of ligase activity (GO:0051352)3.37006600
41protein complex biogenesis (GO:0070271)3.36341110
42cytochrome complex assembly (GO:0017004)3.36249902
43rRNA methylation (GO:0031167)3.34438361
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.33768325
45establishment of integrated proviral latency (GO:0075713)3.33577950
46one-carbon metabolic process (GO:0006730)3.33358304
47protein deneddylation (GO:0000338)3.32127650
48telomere maintenance via recombination (GO:0000722)3.29792836
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.29398115
50regulation of mitotic spindle checkpoint (GO:1903504)3.29398115
51regulation of RIG-I signaling pathway (GO:0039535)3.29027589
52nitrogen cycle metabolic process (GO:0071941)3.27731488
53establishment of chromosome localization (GO:0051303)3.27267027
54tetrahydrofolate metabolic process (GO:0046653)3.26358848
55regulation of cellular amino acid metabolic process (GO:0006521)3.25917866
56sulfur amino acid catabolic process (GO:0000098)3.25758987
57histone mRNA metabolic process (GO:0008334)3.25734581
58DNA strand elongation involved in DNA replication (GO:0006271)3.25055395
59serine family amino acid biosynthetic process (GO:0009070)3.25026405
60mitochondrial respiratory chain complex assembly (GO:0033108)3.23892820
61tyrosine metabolic process (GO:0006570)3.23133314
62lactate metabolic process (GO:0006089)3.22464954
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22405583
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22405583
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22405583
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22189173
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21280500
68negative regulation of DNA-dependent DNA replication (GO:2000104)3.20272467
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20133214
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20133214
71negative regulation of fibrinolysis (GO:0051918)3.19288115
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.18671138
73NADH dehydrogenase complex assembly (GO:0010257)3.18671138
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18671138
75purine nucleobase biosynthetic process (GO:0009113)3.18388976
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18263489
77L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17473010
78water-soluble vitamin biosynthetic process (GO:0042364)3.17219368
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17198936
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17198936
81glycine metabolic process (GO:0006544)3.16619226
82mitotic recombination (GO:0006312)3.15634638
83peptidyl-histidine modification (GO:0018202)3.14653418
84peptidyl-glutamic acid carboxylation (GO:0017187)3.12273748
85protein carboxylation (GO:0018214)3.12273748
86platelet dense granule organization (GO:0060155)3.11715641
87regulation of centriole replication (GO:0046599)3.11542012
88ethanol oxidation (GO:0006069)3.10631696
89triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.10580201
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09158515
91signal transduction involved in DNA damage checkpoint (GO:0072422)3.08047869
92signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08047869
93DNA strand elongation (GO:0022616)3.07651680
94non-recombinational repair (GO:0000726)3.07489230
95double-strand break repair via nonhomologous end joining (GO:0006303)3.07489230
96spliceosomal snRNP assembly (GO:0000387)3.07211375
97signal transduction involved in cell cycle checkpoint (GO:0072395)3.06912147
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04693220
99RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04142344
100nucleoside salvage (GO:0043174)3.03778951
101kinetochore organization (GO:0051383)3.03437130
102high-density lipoprotein particle remodeling (GO:0034375)3.03321721
103aromatic amino acid family metabolic process (GO:0009072)3.01922883
104attachment of spindle microtubules to kinetochore (GO:0008608)3.01767089
105mitotic chromosome condensation (GO:0007076)3.01072796
106DNA replication-independent nucleosome organization (GO:0034724)3.00265984
107DNA replication-independent nucleosome assembly (GO:0006336)3.00265984
108regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.99374697
109serine family amino acid catabolic process (GO:0009071)2.99177404
1107-methylguanosine mRNA capping (GO:0006370)2.97333239
111regulation of protein activation cascade (GO:2000257)2.96633355
112pteridine-containing compound biosynthetic process (GO:0042559)2.95243763
113mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94882655
114chaperone-mediated protein transport (GO:0072321)2.93334866
115branched-chain amino acid catabolic process (GO:0009083)2.93297555
116L-serine metabolic process (GO:0006563)2.93256821
117establishment of viral latency (GO:0019043)2.92981239
118positive regulation of ligase activity (GO:0051351)2.91536993
119regulation of fibrinolysis (GO:0051917)2.90691131
120transcription elongation from RNA polymerase I promoter (GO:0006362)2.89924473
121serine family amino acid metabolic process (GO:0009069)2.89519385
1227-methylguanosine RNA capping (GO:0009452)2.89511739
123RNA capping (GO:0036260)2.89511739
124kinetochore assembly (GO:0051382)2.89298163
125nucleobase biosynthetic process (GO:0046112)2.88349572
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88120007
127transcription from mitochondrial promoter (GO:0006390)2.85058435
128mitochondrial RNA metabolic process (GO:0000959)2.84868730
129regulation of spindle organization (GO:0090224)2.84866670
130COPI coating of Golgi vesicle (GO:0048205)2.84612083
131Golgi transport vesicle coating (GO:0048200)2.84612083
132single strand break repair (GO:0000012)2.83876316
133nucleotide-excision repair, DNA gap filling (GO:0006297)2.83642414
134folic acid-containing compound metabolic process (GO:0006760)2.83496406
135signal peptide processing (GO:0006465)2.82915265
136pyrimidine-containing compound salvage (GO:0008655)2.82192683
137pyrimidine nucleoside salvage (GO:0043097)2.82192683
138double-strand break repair via homologous recombination (GO:0000724)2.80529182
139telomere maintenance via telomere lengthening (GO:0010833)2.80361073
140recombinational repair (GO:0000725)2.79625129
141regulation of female gonad development (GO:2000194)2.78778636
142pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.78518630
143DNA replication-dependent nucleosome assembly (GO:0006335)2.78501949
144DNA replication-dependent nucleosome organization (GO:0034723)2.78501949
145dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.78126345
146folic acid metabolic process (GO:0046655)2.77073284
147bile acid metabolic process (GO:0008206)2.76739494
148regulation of complement activation (GO:0030449)2.75809720
149protein localization to kinetochore (GO:0034501)2.74908322
150amino-acid betaine metabolic process (GO:0006577)2.74579408
151complement activation, alternative pathway (GO:0006957)2.73960027
152indolalkylamine metabolic process (GO:0006586)2.73793067
153CENP-A containing nucleosome assembly (GO:0034080)2.72861463
154regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70633103
155lysine catabolic process (GO:0006554)2.68092177
156lysine metabolic process (GO:0006553)2.68092177
157aldehyde catabolic process (GO:0046185)2.64860957
158urate metabolic process (GO:0046415)2.64813767
159meiotic chromosome segregation (GO:0045132)2.64231778
160regulation of mitotic spindle organization (GO:0060236)2.62039664
161response to nitrosative stress (GO:0051409)2.61124932
162arginine metabolic process (GO:0006525)2.60770039
163DNA replication checkpoint (GO:0000076)2.60429566
164pyrimidine nucleoside catabolic process (GO:0046135)2.59707830
165pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.59462994
166UMP biosynthetic process (GO:0006222)2.59462994
167pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.59462994
168UMP metabolic process (GO:0046049)2.59462994
169chromatin remodeling at centromere (GO:0031055)2.58075512
170killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.55383629
171disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.55383629
172alpha-amino acid catabolic process (GO:1901606)2.55178368
173pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.54892167
174cellular glucuronidation (GO:0052695)2.51601568
175valine metabolic process (GO:0006573)2.50331519
176regulation of cholesterol esterification (GO:0010872)2.49569985
177triglyceride homeostasis (GO:0070328)2.48402369
178acylglycerol homeostasis (GO:0055090)2.48402369
179pteridine-containing compound metabolic process (GO:0042558)2.48048346
180misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.47672017
181cellular biogenic amine catabolic process (GO:0042402)2.46911002
182amine catabolic process (GO:0009310)2.46911002
183fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.46187702
184alpha-linolenic acid metabolic process (GO:0036109)2.45489570
185phospholipid efflux (GO:0033700)2.43550780
186protein-lipid complex remodeling (GO:0034368)2.42775738
187macromolecular complex remodeling (GO:0034367)2.42775738
188plasma lipoprotein particle remodeling (GO:0034369)2.42775738
189benzene-containing compound metabolic process (GO:0042537)2.42759916
190imidazole-containing compound metabolic process (GO:0052803)2.41710608
191homocysteine metabolic process (GO:0050667)2.40279808
192mitotic nuclear envelope disassembly (GO:0007077)2.40073018
193regulation of exit from mitosis (GO:0007096)2.39814272
194S-adenosylmethionine metabolic process (GO:0046500)2.39236540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.15130670
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.12877554
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.73579580
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.66100649
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.65530570
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.30583061
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.14687175
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90848422
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.85071865
10AR_21909140_ChIP-Seq_LNCAP_Human2.77654699
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.71236386
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.55279522
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.44706201
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.39673553
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36440248
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.30158333
17ZNF274_21170338_ChIP-Seq_K562_Hela2.15609880
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06782134
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05608566
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04055776
21EWS_26573619_Chip-Seq_HEK293_Human2.00363468
22VDR_22108803_ChIP-Seq_LS180_Human1.99993397
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99245220
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98069573
25FUS_26573619_Chip-Seq_HEK293_Human1.97611093
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95259040
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90154816
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.84841125
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84153031
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83896036
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75848209
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72650773
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70920555
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69624378
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.67839917
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65651450
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65165843
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64350334
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.62930109
40* ETS1_20019798_ChIP-Seq_JURKAT_Human1.60867146
41* DCP1A_22483619_ChIP-Seq_HELA_Human1.56148656
42* GABP_19822575_ChIP-Seq_HepG2_Human1.52641596
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52483772
44* SRF_21415370_ChIP-Seq_HL-1_Mouse1.51691394
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48881301
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45795419
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45793784
48VDR_23849224_ChIP-Seq_CD4+_Human1.45731461
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44336966
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42993448
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41460560
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41361633
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40078899
54FOXP3_21729870_ChIP-Seq_TREG_Human1.37154398
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36970525
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35165065
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33196828
58P300_19829295_ChIP-Seq_ESCs_Human1.27056505
59XRN2_22483619_ChIP-Seq_HELA_Human1.26947128
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26563667
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25260912
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24717766
63TAF15_26573619_Chip-Seq_HEK293_Human1.23256083
64IGF1R_20145208_ChIP-Seq_DFB_Human1.23180956
65ELK1_19687146_ChIP-ChIP_HELA_Human1.23158302
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22406572
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21093100
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19868138
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19829768
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19450505
71IRF1_19129219_ChIP-ChIP_H3396_Human1.18298430
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17937216
73* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17414095
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13055891
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11712287
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11582879
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.10973278
78* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10874699
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09223680
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08910685
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08303704
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.08303704
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07461257
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07339423
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05829421
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.05756543
87MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05636952
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05202185
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04922715
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.04764247
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04389164
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03856419
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03265270
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.03115003
95KDM5A_27292631_Chip-Seq_BREAST_Human1.02500143
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02431840
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00051846
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98972336
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98814051
100* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98367409
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97543811
102NANOG_19829295_ChIP-Seq_ESCs_Human0.97317761
103SOX2_19829295_ChIP-Seq_ESCs_Human0.97317761
104MYC_18940864_ChIP-ChIP_HL60_Human0.97177841
105* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97050600
106HTT_18923047_ChIP-ChIP_STHdh_Human0.95549297
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93655827
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93398169
109CBP_20019798_ChIP-Seq_JUKART_Human0.93398169
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92495329
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.91828758
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91372238
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90926223
114SALL1_21062744_ChIP-ChIP_HESCs_Human0.90566965
115* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90492935
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89547412
117* SALL4_22934838_ChIP-ChIP_CD34+_Human0.89509294
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88722136
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88376248
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88193844
121ER_23166858_ChIP-Seq_MCF-7_Human0.88035633
122* TP53_22573176_ChIP-Seq_HFKS_Human0.87047256
123FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86994971
124PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86986431
125* TTF2_22483619_ChIP-Seq_HELA_Human0.86972601
126SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86427858
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85422181
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85060857
129CRX_20693478_ChIP-Seq_RETINA_Mouse0.84997666
130EGR1_19374776_ChIP-ChIP_THP-1_Human0.84944026
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84605800
132TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84495924
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83422892
134IRF8_21731497_ChIP-ChIP_J774_Mouse0.82971835
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82279726
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.81193398
137CLOCK_20551151_ChIP-Seq_293T_Human0.80910250
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80661392
139TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80326120
140TFEB_21752829_ChIP-Seq_HELA_Human0.80110987
141ELK1_22589737_ChIP-Seq_MCF10A_Human0.76572086
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74670832
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72688814
144CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70965926
145* SPI1_23547873_ChIP-Seq_NB4_Human0.70504616
146NOTCH1_21737748_ChIP-Seq_TLL_Human0.68612532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.14344312
2MP0003806_abnormal_nucleotide_metabolis4.36858964
3MP0005360_urolithiasis4.30054173
4MP0005085_abnormal_gallbladder_physiolo3.70149861
5MP0005365_abnormal_bile_salt3.54797886
6MP0005451_abnormal_body_composition3.23756407
7MP0008875_abnormal_xenobiotic_pharmacok3.19897120
8MP0000569_abnormal_digit_pigmentation3.18676434
9MP0005075_abnormal_melanosome_morpholog2.97080526
10MP0003693_abnormal_embryo_hatching2.90564858
11MP0002938_white_spotting2.68853649
12MP0005408_hypopigmentation2.64540448
13MP0000372_irregular_coat_pigmentation2.60100087
14MP0005367_renal/urinary_system_phenotyp2.51933702
15MP0000516_abnormal_urinary_system2.51933702
16MP0003718_maternal_effect2.21754072
17MP0005083_abnormal_biliary_tract2.20294292
18MP0010368_abnormal_lymphatic_system2.17018538
19MP0006072_abnormal_retinal_apoptosis2.09462117
20MP0003252_abnormal_bile_duct2.06604108
21MP0008877_abnormal_DNA_methylation2.03378218
22MP0009697_abnormal_copulation2.03310338
23MP0010094_abnormal_chromosome_stability1.99159238
24MP0003786_premature_aging1.97959331
25MP0009840_abnormal_foam_cell1.91658442
26MP0003077_abnormal_cell_cycle1.90218475
27MP0003186_abnormal_redox_activity1.88430788
28MP0005174_abnormal_tail_pigmentation1.86705390
29MP0004957_abnormal_blastocyst_morpholog1.84455023
30MP0003111_abnormal_nucleus_morphology1.81119146
31MP0010329_abnormal_lipoprotein_level1.69656046
32MP0002138_abnormal_hepatobiliary_system1.63806874
33MP0003941_abnormal_skin_development1.60686883
34MP0005253_abnormal_eye_physiology1.54466085
35MP0003567_abnormal_fetal_cardiomyocyte1.52077994
36MP0006035_abnormal_mitochondrial_morpho1.51310043
37MP0001324_abnormal_eye_pigmentation1.49835351
38MP0002090_abnormal_vision1.44916448
39MP0001764_abnormal_homeostasis1.44700268
40MP0001666_abnormal_nutrient_absorption1.43309668
41MP0005332_abnormal_amino_acid1.41989226
42MP0003123_paternal_imprinting1.39809169
43MP0005084_abnormal_gallbladder_morpholo1.37684743
44MP0000609_abnormal_liver_physiology1.37576172
45MP0010307_abnormal_tumor_latency1.32267823
46MP0003656_abnormal_erythrocyte_physiolo1.29640479
47MP0005395_other_phenotype1.28825870
48MP0001293_anophthalmia1.27917967
49MP0005220_abnormal_exocrine_pancreas1.26631950
50MP0003705_abnormal_hypodermis_morpholog1.26521378
51MP0005551_abnormal_eye_electrophysiolog1.25830664
52MP0002132_abnormal_respiratory_system1.25696165
53MP0002095_abnormal_skin_pigmentation1.25443311
54MP0001119_abnormal_female_reproductive1.24520728
55MP0001529_abnormal_vocalization1.24483867
56MP0008007_abnormal_cellular_replicative1.24248450
57MP0006292_abnormal_olfactory_placode1.23834029
58MP0004147_increased_porphyrin_level1.22624029
59MP0003195_calcinosis1.19114743
60MP0000371_diluted_coat_color1.17960156
61MP0002163_abnormal_gland_morphology1.17876078
62MP0006054_spinal_hemorrhage1.16813190
63MP0000015_abnormal_ear_pigmentation1.16758039
64MP0000598_abnormal_liver_morphology1.08371899
65MP0005023_abnormal_wound_healing1.03906218
66MP0003937_abnormal_limbs/digits/tail_de1.03897388
67MP0004782_abnormal_surfactant_physiolog1.02163098
68MP0001188_hyperpigmentation1.01862520
69MP0001984_abnormal_olfaction1.01697203
70MP0005319_abnormal_enzyme/_coenzyme1.00373546
71MP0003763_abnormal_thymus_physiology1.00165849
72MP0003119_abnormal_digestive_system0.99444319
73MP0004019_abnormal_vitamin_homeostasis0.98453850
74MP0002234_abnormal_pharynx_morphology0.97989472
75MP0001915_intracranial_hemorrhage0.96644001
76MP0000358_abnormal_cell_content/0.96425778
77MP0009643_abnormal_urine_homeostasis0.95719970
78MP0008058_abnormal_DNA_repair0.95022874
79MP0001730_embryonic_growth_arrest0.94280256
80MP0001929_abnormal_gametogenesis0.93318448
81MP0004215_abnormal_myocardial_fiber0.92469487
82MP0000647_abnormal_sebaceous_gland0.92356079
83MP0002254_reproductive_system_inflammat0.92196285
84MP0003868_abnormal_feces_composition0.89636197
85MP0002396_abnormal_hematopoietic_system0.89486364
86MP0008932_abnormal_embryonic_tissue0.89312120
87MP0002210_abnormal_sex_determination0.87704300
88MP0003699_abnormal_female_reproductive0.87531125
89MP0004264_abnormal_extraembryonic_tissu0.86001303
90MP0008872_abnormal_physiological_respon0.85779662
91MP0000653_abnormal_sex_gland0.85278587
92MP0009763_increased_sensitivity_to0.85026525
93MP0002102_abnormal_ear_morphology0.84844689
94MP0005645_abnormal_hypothalamus_physiol0.84139427
95MP0002075_abnormal_coat/hair_pigmentati0.83821164
96MP0002118_abnormal_lipid_homeostasis0.83401358
97MP0001145_abnormal_male_reproductive0.82651593
98MP0003136_yellow_coat_color0.82072078
99MP0009384_cardiac_valve_regurgitation0.81204773
100MP0005389_reproductive_system_phenotype0.80052194
101MP0005391_vision/eye_phenotype0.79884353
102MP0001697_abnormal_embryo_size0.79347650
103MP0003121_genomic_imprinting0.78951090
104MP0003191_abnormal_cellular_cholesterol0.78245554
105MP0010234_abnormal_vibrissa_follicle0.77481369
106MP0003950_abnormal_plasma_membrane0.76868954
107MP0003943_abnormal_hepatobiliary_system0.76791437
108MP0001186_pigmentation_phenotype0.76308970
109MP0008873_increased_physiological_sensi0.75907516
110MP0005379_endocrine/exocrine_gland_phen0.75422794
111MP0000313_abnormal_cell_death0.75372546
112MP0002638_abnormal_pupillary_reflex0.75225639
113MP0003221_abnormal_cardiomyocyte_apopto0.75057729
114MP0002019_abnormal_tumor_incidence0.74762189
115MP0005266_abnormal_metabolism0.74410063
116MP0004133_heterotaxia0.73581141
117MP0006036_abnormal_mitochondrial_physio0.73278303
118MP0003011_delayed_dark_adaptation0.72884066
119MP0002084_abnormal_developmental_patter0.72315404
120MP0001919_abnormal_reproductive_system0.71119479
121MP0010030_abnormal_orbit_morphology0.70864816
122MP0001672_abnormal_embryogenesis/_devel0.70755878
123MP0005380_embryogenesis_phenotype0.70755878
124MP0002877_abnormal_melanocyte_morpholog0.70350354
125MP0003646_muscle_fatigue0.70125257
126MP0000350_abnormal_cell_proliferation0.69217188
127MP0001485_abnormal_pinna_reflex0.69207724
128MP0003984_embryonic_growth_retardation0.69021464
129MP0002751_abnormal_autonomic_nervous0.68238697
130MP0005376_homeostasis/metabolism_phenot0.68085393
131MP0002088_abnormal_embryonic_growth/wei0.67394168
132MP0009053_abnormal_anal_canal0.66185939
133MP0009764_decreased_sensitivity_to0.65079603
134MP0003436_decreased_susceptibility_to0.64987490
135MP0003453_abnormal_keratinocyte_physiol0.64617528
136MP0008995_early_reproductive_senescence0.64196551
137MP0002160_abnormal_reproductive_system0.63907000
138MP0003890_abnormal_embryonic-extraembry0.63577266
139MP0009333_abnormal_splenocyte_physiolog0.63483254
140MP0005647_abnormal_sex_gland0.63446148
141MP0000639_abnormal_adrenal_gland0.63328670
142MP0008438_abnormal_cutaneous_collagen0.62456907
143MP0000689_abnormal_spleen_morphology0.61643563
144MP0005584_abnormal_enzyme/coenzyme_acti0.61473543
145MP0002653_abnormal_ependyma_morphology0.61392096
146MP0008469_abnormal_protein_level0.61269565
147MP0002282_abnormal_trachea_morphology0.61095037
148MP0002405_respiratory_system_inflammati0.60597155
149MP0000858_altered_metastatic_potential0.59955870
150MP0002086_abnormal_extraembryonic_tissu0.58573858
151MP0000685_abnormal_immune_system0.57830029
152MP0001756_abnormal_urination0.57306648
153MP0002933_joint_inflammation0.56384304
154MP0002837_dystrophic_cardiac_calcinosis0.56295008
155MP0005636_abnormal_mineral_homeostasis0.55918765
156MP0005397_hematopoietic_system_phenotyp0.55057619
157MP0001545_abnormal_hematopoietic_system0.55057619
158MP0008057_abnormal_DNA_replication0.55036627

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.98007662
2Deep venous thrombosis (HP:0002625)4.70427601
3Intrahepatic cholestasis (HP:0001406)4.62379472
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.37832806
5Hypobetalipoproteinemia (HP:0003563)3.97509624
6Birth length less than 3rd percentile (HP:0003561)3.60167096
7Prolonged partial thromboplastin time (HP:0003645)3.55796144
8Methylmalonic acidemia (HP:0002912)3.47653858
9Breast hypoplasia (HP:0003187)3.26480115
10Increased CSF lactate (HP:0002490)3.24870055
11Acute necrotizing encephalopathy (HP:0006965)3.22368622
12Abnormality of the intrinsic pathway (HP:0010989)3.22069954
13Acute encephalopathy (HP:0006846)3.20669153
14Xanthomatosis (HP:0000991)3.17001162
15Hepatocellular necrosis (HP:0001404)3.14770489
16Mitochondrial inheritance (HP:0001427)3.14197918
17Pancreatic cysts (HP:0001737)3.14085795
18Abnormality of pyrimidine metabolism (HP:0004353)3.09610547
19Lipid accumulation in hepatocytes (HP:0006561)3.04494071
20Abnormality of the common coagulation pathway (HP:0010990)3.01979412
21Abnormality of methionine metabolism (HP:0010901)3.01319365
22Male infertility (HP:0003251)3.00411208
23Abnormal mitochondria in muscle tissue (HP:0008316)2.98032264
24Hyperammonemia (HP:0001987)2.93563741
25Progressive macrocephaly (HP:0004481)2.86299232
26Methylmalonic aciduria (HP:0012120)2.85124406
27B lymphocytopenia (HP:0010976)2.82729423
28Pancreatic fibrosis (HP:0100732)2.82397351
29Increased hepatocellular lipid droplets (HP:0006565)2.79198786
30Hyperlipoproteinemia (HP:0010980)2.78247526
31Fat malabsorption (HP:0002630)2.77961877
32Abnormality of sulfur amino acid metabolism (HP:0004339)2.76115435
33Increased serum lactate (HP:0002151)2.75604652
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74402133
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74402133
36Papillary thyroid carcinoma (HP:0002895)2.72771785
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70607962
38Complement deficiency (HP:0004431)2.70248312
39True hermaphroditism (HP:0010459)2.68619600
40Conjugated hyperbilirubinemia (HP:0002908)2.63774629
41Hypolipoproteinemia (HP:0010981)2.62928622
42Hypoglycemic coma (HP:0001325)2.62452567
43Malnutrition (HP:0004395)2.61171085
44Hyperglycinemia (HP:0002154)2.59372861
45Abnormality of B cell number (HP:0010975)2.58821901
46Abnormality of alanine metabolism (HP:0010916)2.58092572
47Hyperalaninemia (HP:0003348)2.58092572
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58092572
49Medial flaring of the eyebrow (HP:0010747)2.55907045
50Type I transferrin isoform profile (HP:0003642)2.53450701
51Meckel diverticulum (HP:0002245)2.52313319
52Hepatocellular carcinoma (HP:0001402)2.50882218
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49761482
54Abnormal protein N-linked glycosylation (HP:0012347)2.49761482
55Abnormal protein glycosylation (HP:0012346)2.49761482
56Abnormal glycosylation (HP:0012345)2.49761482
57Joint hemorrhage (HP:0005261)2.47599611
58Cortical dysplasia (HP:0002539)2.43893547
59Diastasis recti (HP:0001540)2.42741464
60Adrenal hypoplasia (HP:0000835)2.42740286
61Abnormality of the ileum (HP:0001549)2.40889574
62Cerebral edema (HP:0002181)2.38427262
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.37354626
64Generalized aminoaciduria (HP:0002909)2.37211089
65Steatorrhea (HP:0002570)2.34329465
66Ketosis (HP:0001946)2.33154639
67Hyperglycemia (HP:0003074)2.30383552
68Intestinal atresia (HP:0011100)2.28262871
69Hyperglycinuria (HP:0003108)2.27293057
70Secondary amenorrhea (HP:0000869)2.26546609
71Aplastic anemia (HP:0001915)2.26543161
72Abnormality of nucleobase metabolism (HP:0010932)2.26153509
73IgM deficiency (HP:0002850)2.26133252
74Aplasia/hypoplasia of the uterus (HP:0008684)2.24891630
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.23524139
76Degeneration of anterior horn cells (HP:0002398)2.22539350
77Abnormality of the anterior horn cell (HP:0006802)2.22539350
78Molar tooth sign on MRI (HP:0002419)2.21449211
79Abnormality of midbrain morphology (HP:0002418)2.21449211
80Increased serum pyruvate (HP:0003542)2.20548062
81Abnormality of serum amino acid levels (HP:0003112)2.19727642
82Abnormality of vitamin B metabolism (HP:0004340)2.18871393
83Sloping forehead (HP:0000340)2.18584543
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17054311
85Dicarboxylic aciduria (HP:0003215)2.17054311
86Carpal bone hypoplasia (HP:0001498)2.16721933
87Abnormality of the pons (HP:0007361)2.16631449
88Abnormality of the vitamin B12 metabolism (HP:0004341)2.15943568
89Lactic acidosis (HP:0003128)2.15741950
90Abnormality of the renal cortex (HP:0011035)2.15316152
91Oral leukoplakia (HP:0002745)2.14692321
92Abnormality of fatty-acid metabolism (HP:0004359)2.14265788
93Flat capital femoral epiphysis (HP:0003370)2.13979767
94Limb hypertonia (HP:0002509)2.13795891
95Hyperbilirubinemia (HP:0002904)2.13528447
96Pancreatic islet-cell hyperplasia (HP:0004510)2.12817533
97Congenital primary aphakia (HP:0007707)2.11057366
98Ketoacidosis (HP:0001993)2.10622908
99Thyroiditis (HP:0100646)2.09386970
100Abnormality of the preputium (HP:0100587)2.09216493
101Median cleft lip (HP:0000161)2.08500991
102Patellar aplasia (HP:0006443)2.07373733
103Epidermoid cyst (HP:0200040)2.06550776
104Severe combined immunodeficiency (HP:0004430)2.05796202
105Hypoplasia of the pons (HP:0012110)2.05046448
106Abnormality of serine family amino acid metabolism (HP:0010894)2.03982963
107Abnormality of glycine metabolism (HP:0010895)2.03982963
108Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03699204
109Spontaneous abortion (HP:0005268)2.02880008
110Abnormality of urine glucose concentration (HP:0011016)2.02873356
111Glycosuria (HP:0003076)2.02873356
112Renal cortical cysts (HP:0000803)2.02699310
113Microretrognathia (HP:0000308)2.02042236
114Abnormality of glycolysis (HP:0004366)2.00565946
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99080635
116Renal Fanconi syndrome (HP:0001994)1.98098258
117Abnormal pancreas size (HP:0012094)1.98046101
118Hypoalphalipoproteinemia (HP:0003233)1.97825952
119Colon cancer (HP:0003003)1.97601977
120Abnormality of the labia minora (HP:0012880)1.97202907
121Abnormal lung lobation (HP:0002101)1.97076106
122Abnormal gallbladder physiology (HP:0012438)1.95305217
123Cholecystitis (HP:0001082)1.95305217
124Duodenal stenosis (HP:0100867)1.94192661
125Small intestinal stenosis (HP:0012848)1.94192661
126Respiratory failure (HP:0002878)1.92884898
127Abnormality of the duodenum (HP:0002246)1.92688696
128Abnormal biliary tract physiology (HP:0012439)1.92075967
129Bile duct proliferation (HP:0001408)1.92075967
130Hypothermia (HP:0002045)1.91183039
131Recurrent gram-negative bacterial infections (HP:0005420)1.90938763
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.90800920
133Neoplasm of the adrenal gland (HP:0100631)1.90433073
134Sclerocornea (HP:0000647)1.90078000
135Capillary hemangiomas (HP:0005306)1.89422009
136Rhabdomyosarcoma (HP:0002859)1.88397111
137Volvulus (HP:0002580)1.88351870
138Gait imbalance (HP:0002141)1.87696303
139Abnormality of complement system (HP:0005339)1.87094782
140Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86979459
141Aplasia/Hypoplasia of the patella (HP:0006498)1.86860849
142Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86066159
143Thrombophlebitis (HP:0004418)1.85492942
144Chromsome breakage (HP:0040012)1.84963637
145Reduced antithrombin III activity (HP:0001976)1.84603576
146Proximal tubulopathy (HP:0000114)1.84509513
147Abnormality of purine metabolism (HP:0004352)1.84424990
148Short tibia (HP:0005736)1.83547207
149Congenital, generalized hypertrichosis (HP:0004540)1.83444383
150Abnormality of homocysteine metabolism (HP:0010919)1.83408709
151Homocystinuria (HP:0002156)1.83408709
152Nephrogenic diabetes insipidus (HP:0009806)1.83155383
153Lethargy (HP:0001254)1.82752688
154Combined immunodeficiency (HP:0005387)1.82645875
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.82595003
156Esophageal varix (HP:0002040)1.81894721
157Exertional dyspnea (HP:0002875)1.81531446
158IgG deficiency (HP:0004315)1.80560895
159CNS demyelination (HP:0007305)1.80334058
160Hypoplastic pelvis (HP:0008839)1.78990309
161Abnormality of chromosome stability (HP:0003220)1.78802101
162Microvesicular hepatic steatosis (HP:0001414)1.78443290
163Abnormality of lateral ventricle (HP:0030047)1.78184184
164Postnatal microcephaly (HP:0005484)1.77885363
165Abnormal cartilage morphology (HP:0002763)1.77256761
166Optic disc pallor (HP:0000543)1.77196297
167Delayed CNS myelination (HP:0002188)1.76960300
168Hypergonadotropic hypogonadism (HP:0000815)1.76648337
169Gout (HP:0001997)1.72385378
170Abnormal tarsal ossification (HP:0008369)1.72235209
171Myocardial infarction (HP:0001658)1.71495590
172Rough bone trabeculation (HP:0100670)1.70675041
173Metabolic acidosis (HP:0001942)1.70548423
1743-Methylglutaconic aciduria (HP:0003535)1.69686614
175Gastrointestinal infarctions (HP:0005244)1.68917790
176Irregular epiphyses (HP:0010582)1.68798722
177Opisthotonus (HP:0002179)1.66523245
178Abnormality of endocrine pancreas physiology (HP:0012093)1.66130419
179Abnormality of the pancreatic islet cells (HP:0006476)1.66130419
180Thrombocytosis (HP:0001894)1.65144357
181Facial hemangioma (HP:0000329)1.64707025
182Abnormal foot bone ossification (HP:0010675)1.63935932
183Hepatic necrosis (HP:0002605)1.62929765
184Premature ovarian failure (HP:0008209)1.59582625
185Autoimmune thrombocytopenia (HP:0001973)1.59170458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.52989687
2TRIM283.33143315
3MST43.25628698
4PLK42.95691017
5ZAK2.65839004
6STK38L2.58899767
7PBK2.49606263
8MAP3K132.47889915
9WNK32.44428953
10NEK12.29901344
11BUB12.24809714
12CDC72.23931663
13TTK2.21717060
14BRAF2.19602669
15MKNK22.18541666
16TSSK62.17999033
17ARAF2.14467787
18ERBB42.13439964
19NUAK12.12573069
20TAF12.12133033
21VRK22.11748435
22TAOK32.06478350
23RPS6KA41.98937902
24BMPR1B1.97547125
25STK31.97141389
26MOS1.93942566
27LATS21.93781003
28CDK81.89718328
29MKNK11.85770778
30BRSK21.84308796
31MAP3K61.81824189
32ERBB31.78169013
33STK101.72126519
34TNIK1.71248108
35BCKDK1.69200353
36NEK91.60810947
37RAF11.60313230
38SRPK11.58093560
39EIF2AK11.57997625
40FLT31.54314153
41EEF2K1.54056189
42BCR1.52686486
43ACVR1B1.47299866
44MAP3K31.44542034
45MELK1.43582224
46NME11.42528843
47NEK21.41046909
48RPS6KB21.34453890
49WEE11.32909608
50MAP3K81.30759871
51TYK21.30550462
52ADRBK21.29606667
53STK161.28548348
54EIF2AK31.26507348
55MAPKAPK31.24886942
56PLK11.24061974
57PDK21.22106767
58KSR21.21146171
59FGFR41.19687229
60JAK31.19611747
61PLK21.17847555
62DYRK21.14535666
63MAP3K91.08472051
64GRK11.07907825
65KDR1.07885657
66PASK1.06327890
67AURKB1.05767185
68NLK1.04747188
69MAP4K21.03285543
70ERN11.02905533
71BMPR21.01162462
72EIF2AK21.00185019
73BRSK10.98428722
74MAP3K120.95069215
75ABL20.92284147
76MAP3K40.91583552
77SIK10.90721722
78PLK30.86145145
79TRPM70.86090440
80TAOK10.82107292
81STK390.80702868
82CDK90.80283576
83MAPK130.78884573
84AKT30.77023709
85VRK10.76844547
86PKN20.75708553
87CHEK20.74308114
88MAP2K70.72876076
89SIK30.72807736
90LMTK20.72777572
91CDK40.72093532
92MAPK110.70171922
93DYRK30.70054810
94TESK10.68354548
95TESK20.66920860
96MAP3K140.66172478
97CSNK1G30.64754880
98CDK70.63214673
99EPHA30.63206041
100MAP2K30.61184173
101CHUK0.60328912
102FGFR30.60107641
103WNK40.58861898
104FRK0.58565866
105CSNK1G20.58191600
106ZAP700.57688220
107STK240.57252262
108AURKA0.55240671
109FGFR10.55128837
110LRRK20.54035063
111TGFBR10.54031064
112FGFR20.53802238
113ATR0.53753938
114CLK10.53684550
115TLK10.53649434
116CDK30.53137649
117PRKG20.52682712
118OXSR10.52663793
119CSNK2A10.52504627
120STK40.51564645
121MAP3K50.51521381
122HIPK20.50785118
123TEC0.50101209
124MUSK0.48534287
125MAP4K10.48495769
126MARK30.47764587
127PRKCI0.46419930
128CSNK2A20.46322126
129DYRK1A0.45843872
130PIK3CG0.45269197
131CSNK1A1L0.45194625
132INSRR0.44247859
133CSNK1G10.43628730
134PRKAA20.43420132
135IRAK40.42643263
136ATM0.42538800
137CDK60.40407651
138SGK30.40125006
139CHEK10.40017217
140PIM10.39621042
141TXK0.39326073
142PRKCE0.39285092
143CCNB10.39242072
144TIE10.38848657
145KIT0.35908230
146LIMK10.35796275
147KSR10.35762445
148IKBKE0.35492105
149PIK3CA0.32550028
150CSNK1A10.29913738
151SCYL20.29692259
152BRD40.29660223
153CSNK1E0.27862392
154RPS6KA50.27272476
155CDK10.23015749

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.53015521
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.91930949
3One carbon pool by folate_Homo sapiens_hsa006702.23215162
4Oxidative phosphorylation_Homo sapiens_hsa001902.22631245
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.20930809
6Drug metabolism - other enzymes_Homo sapiens_hsa009832.09413748
7Folate biosynthesis_Homo sapiens_hsa007902.04684630
8DNA replication_Homo sapiens_hsa030302.01762019
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97658763
10Tryptophan metabolism_Homo sapiens_hsa003801.92441550
11Complement and coagulation cascades_Homo sapiens_hsa046101.91767024
12Protein export_Homo sapiens_hsa030601.89702099
13Arginine biosynthesis_Homo sapiens_hsa002201.86824656
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.85565115
15Parkinsons disease_Homo sapiens_hsa050121.83739681
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83454541
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82977323
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82681576
19Fatty acid degradation_Homo sapiens_hsa000711.79106954
20Cell cycle_Homo sapiens_hsa041101.76887659
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74113459
22Chemical carcinogenesis_Homo sapiens_hsa052041.71231074
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68071267
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67804844
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67413735
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66606448
27Selenocompound metabolism_Homo sapiens_hsa004501.61052859
28Peroxisome_Homo sapiens_hsa041461.54407399
29Retinol metabolism_Homo sapiens_hsa008301.51670356
30Mismatch repair_Homo sapiens_hsa034301.48933602
31RNA degradation_Homo sapiens_hsa030181.48245303
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.48132405
33Tyrosine metabolism_Homo sapiens_hsa003501.44575446
34Base excision repair_Homo sapiens_hsa034101.40524449
35Pyrimidine metabolism_Homo sapiens_hsa002401.40163343
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.38189572
37Homologous recombination_Homo sapiens_hsa034401.37632510
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36297828
39Histidine metabolism_Homo sapiens_hsa003401.36081355
40RNA polymerase_Homo sapiens_hsa030201.32726021
41Nucleotide excision repair_Homo sapiens_hsa034201.32701857
42Biosynthesis of amino acids_Homo sapiens_hsa012301.31332397
43Ribosome_Homo sapiens_hsa030101.29929670
44Huntingtons disease_Homo sapiens_hsa050161.26768556
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25330255
46Non-homologous end-joining_Homo sapiens_hsa034501.21423124
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21261439
48Basal transcription factors_Homo sapiens_hsa030221.18120599
49Propanoate metabolism_Homo sapiens_hsa006401.16769384
50Pentose phosphate pathway_Homo sapiens_hsa000301.14763668
51Caffeine metabolism_Homo sapiens_hsa002321.13968434
52Phenylalanine metabolism_Homo sapiens_hsa003601.13518706
53Sulfur metabolism_Homo sapiens_hsa009201.10676287
54Vitamin B6 metabolism_Homo sapiens_hsa007501.10119444
55Staphylococcus aureus infection_Homo sapiens_hsa051501.09320404
56Proteasome_Homo sapiens_hsa030501.03157076
57Glutathione metabolism_Homo sapiens_hsa004801.02889605
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00218940
59RNA transport_Homo sapiens_hsa030130.99428845
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99172370
61beta-Alanine metabolism_Homo sapiens_hsa004100.99130125
62p53 signaling pathway_Homo sapiens_hsa041150.97600965
63Alzheimers disease_Homo sapiens_hsa050100.96279244
64Starch and sucrose metabolism_Homo sapiens_hsa005000.89870908
65Pyruvate metabolism_Homo sapiens_hsa006200.89109545
66Carbon metabolism_Homo sapiens_hsa012000.87409441
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87364178
68Arginine and proline metabolism_Homo sapiens_hsa003300.86941934
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86851605
70Linoleic acid metabolism_Homo sapiens_hsa005910.86679048
71Butanoate metabolism_Homo sapiens_hsa006500.86155537
72Nitrogen metabolism_Homo sapiens_hsa009100.85376738
73PPAR signaling pathway_Homo sapiens_hsa033200.84194170
74Ovarian steroidogenesis_Homo sapiens_hsa049130.79852067
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77307659
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73379669
77Fanconi anemia pathway_Homo sapiens_hsa034600.70903878
78Fatty acid metabolism_Homo sapiens_hsa012120.69698403
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68068942
80N-Glycan biosynthesis_Homo sapiens_hsa005100.66952269
81Oocyte meiosis_Homo sapiens_hsa041140.64306056
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63484866
83TGF-beta signaling pathway_Homo sapiens_hsa043500.63013103
84Spliceosome_Homo sapiens_hsa030400.62465128
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62292998
86Steroid biosynthesis_Homo sapiens_hsa001000.62271825
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62228576
88ABC transporters_Homo sapiens_hsa020100.61001834
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58880029
90Sulfur relay system_Homo sapiens_hsa041220.58819939
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56992952
92Primary immunodeficiency_Homo sapiens_hsa053400.56059022
93Collecting duct acid secretion_Homo sapiens_hsa049660.55483273
94Fat digestion and absorption_Homo sapiens_hsa049750.54412504
95mRNA surveillance pathway_Homo sapiens_hsa030150.54255317
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53434820
97Purine metabolism_Homo sapiens_hsa002300.52840412
98Bile secretion_Homo sapiens_hsa049760.50584845
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50518607
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50037935
101Vitamin digestion and absorption_Homo sapiens_hsa049770.48930442
102Lysine degradation_Homo sapiens_hsa003100.48925606
103* Metabolic pathways_Homo sapiens_hsa011000.48879500
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47998004
105Phototransduction_Homo sapiens_hsa047440.47794293
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.43792721
107Galactose metabolism_Homo sapiens_hsa000520.40779010
108Antigen processing and presentation_Homo sapiens_hsa046120.37419685
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36686779
110Herpes simplex infection_Homo sapiens_hsa051680.36573261
111Arachidonic acid metabolism_Homo sapiens_hsa005900.36474554
112Fatty acid elongation_Homo sapiens_hsa000620.33103966
113Ether lipid metabolism_Homo sapiens_hsa005650.31871319
114Other glycan degradation_Homo sapiens_hsa005110.31382173
115Regulation of autophagy_Homo sapiens_hsa041400.30604281
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29553150
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28829734
118Thyroid cancer_Homo sapiens_hsa052160.24248437
119Pancreatic cancer_Homo sapiens_hsa052120.24215903
120Legionellosis_Homo sapiens_hsa051340.23423252
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23055308
122Circadian rhythm_Homo sapiens_hsa047100.15812841
123Taste transduction_Homo sapiens_hsa047420.15636078

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