TGFA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.24647504
2central nervous system myelination (GO:0022010)8.24647504
3desmosome organization (GO:0002934)6.77158043
4fatty acid elongation (GO:0030497)6.17946500
5keratinocyte proliferation (GO:0043616)5.44793762
6membrane raft organization (GO:0031579)4.91263080
7axon ensheathment (GO:0008366)4.74668475
8ensheathment of neurons (GO:0007272)4.74668475
9myelination (GO:0042552)4.73965899
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.72555644
11cell-substrate junction assembly (GO:0007044)4.67648667
12regulation of water loss via skin (GO:0033561)4.65595786
13establishment of skin barrier (GO:0061436)4.61358471
14cell adhesion mediated by integrin (GO:0033627)4.57283818
15surfactant homeostasis (GO:0043129)4.52118841
16hypotonic response (GO:0006971)4.46518389
17response to methylmercury (GO:0051597)4.26911674
18long-chain fatty acid biosynthetic process (GO:0042759)4.09242121
19diterpenoid biosynthetic process (GO:0016102)3.94910996
20myelin maintenance (GO:0043217)3.92294599
21negative regulation of neurotransmitter transport (GO:0051589)3.89025715
22Golgi transport vesicle coating (GO:0048200)3.88731117
23COPI coating of Golgi vesicle (GO:0048205)3.88731117
24skin morphogenesis (GO:0043589)3.87690114
25negative regulation of keratinocyte proliferation (GO:0010839)3.87136113
26L-amino acid import (GO:0043092)3.86055891
27regulation of apoptotic process involved in morphogenesis (GO:1902337)3.74554874
28chemical homeostasis within a tissue (GO:0048875)3.70064001
29negative regulation of neurotransmitter secretion (GO:0046929)3.67908473
30peptidyl-proline hydroxylation (GO:0019511)3.64939775
31cholesterol biosynthetic process (GO:0006695)3.64208705
32pyrimidine nucleoside salvage (GO:0043097)3.63247447
33pyrimidine-containing compound salvage (GO:0008655)3.63247447
34mesodermal cell differentiation (GO:0048333)3.59951985
35protein hydroxylation (GO:0018126)3.53004988
36long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.52164077
37negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.51903040
38negative regulation of protein localization to cell surface (GO:2000009)3.50606948
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.48190157
40activation of Rac GTPase activity (GO:0032863)3.33739193
41positive regulation of Cdc42 GTPase activity (GO:0043089)3.26587994
42long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.23455672
43mammary gland epithelial cell proliferation (GO:0033598)3.21168355
44sterol biosynthetic process (GO:0016126)3.19692397
45fatty-acyl-CoA biosynthetic process (GO:0046949)3.16108958
46peptidyl-tyrosine autophosphorylation (GO:0038083)3.15822425
47regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.14973325
48substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.13044771
49substrate-independent telencephalic tangential migration (GO:0021826)3.13044771
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.11571348
51presynaptic membrane organization (GO:0097090)3.10910410
52regulation of transforming growth factor beta2 production (GO:0032909)3.10869277
53regulation of lipoprotein metabolic process (GO:0050746)3.10728937
54glycerophospholipid catabolic process (GO:0046475)3.10277744
55regulation of metalloenzyme activity (GO:0048552)3.10174335
56positive regulation of epidermal cell differentiation (GO:0045606)3.09674894
57synaptic vesicle maturation (GO:0016188)3.08524017
58protein retention in ER lumen (GO:0006621)3.07449216
59keratinocyte differentiation (GO:0030216)3.06651956
60establishment of mitochondrion localization (GO:0051654)3.05742949
61amino acid import (GO:0043090)3.05412422
62very long-chain fatty acid metabolic process (GO:0000038)3.05379506
63photoreceptor cell differentiation (GO:0046530)3.04753415
64eye photoreceptor cell differentiation (GO:0001754)3.04753415
65multicellular organismal water homeostasis (GO:0050891)3.04423939
66import into cell (GO:0098657)3.02442765
67apical protein localization (GO:0045176)3.02406229
68positive regulation of epidermis development (GO:0045684)3.01867535
69oligodendrocyte differentiation (GO:0048709)3.01340412
70decidualization (GO:0046697)3.00978453
71response to peptidoglycan (GO:0032494)2.99668965
72keratinization (GO:0031424)2.98042210
73fatty-acyl-CoA metabolic process (GO:0035337)2.94535518
74locomotory exploration behavior (GO:0035641)2.92824205
75dendritic spine morphogenesis (GO:0060997)2.92157659
76regulation of collateral sprouting (GO:0048670)2.90811556
77asymmetric protein localization (GO:0008105)2.88740570
78neuron cell-cell adhesion (GO:0007158)2.87324016
79gap junction assembly (GO:0016264)2.86166902
80L-phenylalanine catabolic process (GO:0006559)2.84705854
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.84705854
82adult walking behavior (GO:0007628)2.84648334
83negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.83080828
84* regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.82798859
85amyloid precursor protein metabolic process (GO:0042982)2.82504952
86sphingosine metabolic process (GO:0006670)2.81905727
87adenosine receptor signaling pathway (GO:0001973)2.81587105
88auditory behavior (GO:0031223)2.81081629
89response to vitamin D (GO:0033280)2.80294824
90positive regulation of keratinocyte differentiation (GO:0045618)2.80119604
91positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79692186
92negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.79134493
93neuronal action potential propagation (GO:0019227)2.78964565
94substrate-dependent cell migration (GO:0006929)2.73305559
95iron coordination entity transport (GO:1901678)2.73043813
96presynaptic membrane assembly (GO:0097105)2.72944596
97negative regulation of glycoprotein biosynthetic process (GO:0010561)2.70541525
98creatine metabolic process (GO:0006600)2.69665123
99membrane tubulation (GO:0097320)2.69022870
100membrane budding (GO:0006900)2.67152492
101regulation of neuronal synaptic plasticity (GO:0048168)2.67024034
102transmission of nerve impulse (GO:0019226)2.66759823
103positive regulation of oligodendrocyte differentiation (GO:0048714)2.66440909
104mating behavior (GO:0007617)2.65859297
105molting cycle (GO:0042303)2.65793934
106hair cycle (GO:0042633)2.65793934
107positive regulation of tissue remodeling (GO:0034105)2.64807741
108isoprenoid biosynthetic process (GO:0008299)2.63509138
109prepulse inhibition (GO:0060134)2.62292165
110water homeostasis (GO:0030104)2.61541613
111peripheral nervous system axon ensheathment (GO:0032292)2.61304372
112myelination in peripheral nervous system (GO:0022011)2.61304372
1134-hydroxyproline metabolic process (GO:0019471)2.61012483
114nerve growth factor signaling pathway (GO:0038180)2.59892302
115glycine transport (GO:0015816)2.59571822
116neuronal ion channel clustering (GO:0045161)2.58730193
117signal complex assembly (GO:0007172)2.58684082
118astrocyte development (GO:0014002)2.58309232
119regulation of transforming growth factor beta1 production (GO:0032908)2.58076290
120regulation of synapse structural plasticity (GO:0051823)2.57661870
121synaptic transmission, dopaminergic (GO:0001963)2.57475462
122iron ion import (GO:0097286)2.56696393
123regulation of keratinocyte proliferation (GO:0010837)2.56067295
124negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54942928
125cellular copper ion homeostasis (GO:0006878)2.54379807
126regulation of hair follicle development (GO:0051797)2.54247826
127neuron remodeling (GO:0016322)2.53789490
128terpenoid biosynthetic process (GO:0016114)2.53325032
129negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.52782754
130thioester biosynthetic process (GO:0035384)2.52343573
131acyl-CoA biosynthetic process (GO:0071616)2.52343573
132negative regulation of anoikis (GO:2000811)2.50844458
133positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50021922
134cerebral cortex radially oriented cell migration (GO:0021799)2.49844055
135epithelial cell-cell adhesion (GO:0090136)2.49283181
136epidermis development (GO:0008544)2.48443002
137regulation of keratinocyte differentiation (GO:0045616)2.48226830
138negative regulation of response to reactive oxygen species (GO:1901032)2.47996597
139positive regulation of adherens junction organization (GO:1903393)2.47878574
140mechanosensory behavior (GO:0007638)2.47829201
141ER overload response (GO:0006983)2.47769602
142hepatocyte differentiation (GO:0070365)2.47380391
143glucose 6-phosphate metabolic process (GO:0051156)2.47337058
144ionotropic glutamate receptor signaling pathway (GO:0035235)2.46463721
145response to lipoprotein particle (GO:0055094)2.46394588
146regulation of vitamin D biosynthetic process (GO:0060556)2.45783200
147dendrite morphogenesis (GO:0048813)2.45644333
148positive regulation of cell junction assembly (GO:1901890)2.45390762
149positive regulation of focal adhesion assembly (GO:0051894)2.45390762
150positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.45040308
151regulation of podosome assembly (GO:0071801)2.44908514
152positive regulation of hair cycle (GO:0042635)2.44793058
153positive regulation of hair follicle development (GO:0051798)2.44793058
154neuromuscular process controlling balance (GO:0050885)2.43955061
155diol metabolic process (GO:0034311)2.43696239
156epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43251691
157neuron recognition (GO:0008038)2.43007753
158axon development (GO:0061564)2.42239298
159protein localization to endosome (GO:0036010)2.42211461
160intermediate filament organization (GO:0045109)2.41764746
161negative regulation of necroptotic process (GO:0060546)2.41540323
162sphingoid metabolic process (GO:0046519)2.40985718
163regulation of catecholamine metabolic process (GO:0042069)2.40464122
164regulation of dopamine metabolic process (GO:0042053)2.40464122
165regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40393907
166heme transport (GO:0015886)2.40205796
167cytoskeletal anchoring at plasma membrane (GO:0007016)2.39540538
168substantia nigra development (GO:0021762)2.38905456
169magnesium ion transport (GO:0015693)2.38448668
170L-phenylalanine metabolic process (GO:0006558)2.38292352
171erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.38292352
172regulation of neurotransmitter uptake (GO:0051580)2.38158382
173behavioral response to cocaine (GO:0048148)2.37791140
174branching involved in mammary gland duct morphogenesis (GO:0060444)2.37456292
175negative regulation of axonogenesis (GO:0050771)2.37228200
176regulation of early endosome to late endosome transport (GO:2000641)2.36779814
177regulation of dendritic spine morphogenesis (GO:0061001)2.36692465
178regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.36666361
179response to auditory stimulus (GO:0010996)2.36483657
180membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36316215
181gamma-aminobutyric acid transport (GO:0015812)2.33811353
182positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.33007494
183G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.32786701
184regulation of necroptotic process (GO:0060544)2.32556387
185regulation of transforming growth factor beta production (GO:0071634)2.32453223
186nucleoside salvage (GO:0043174)2.31933783
187detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.31882267
188detection of temperature stimulus involved in sensory perception (GO:0050961)2.31882267
189regulation of synaptic vesicle exocytosis (GO:2000300)2.31632763
190positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.31275615
191membrane protein ectodomain proteolysis (GO:0006509)2.30351346
192epidermal cell differentiation (GO:0009913)2.30350057
193negative regulation of chondrocyte differentiation (GO:0032331)2.29596050
194response to muramyl dipeptide (GO:0032495)2.28955071
195neutrophil activation involved in immune response (GO:0002283)2.28917880
196endocytic recycling (GO:0032456)2.28719099
197positive regulation of protein localization to plasma membrane (GO:1903078)2.27985217
198detection of other organism (GO:0098543)2.27247176
199hemidesmosome assembly (GO:0031581)10.6623352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.98161557
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.53698604
3* SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.07095277
4* SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.07095277
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94882790
6EZH2_22144423_ChIP-Seq_EOC_Human2.65373628
7KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.62765349
8* GBX2_23144817_ChIP-Seq_PC3_Human2.59003743
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53197047
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45454864
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.45268356
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42556462
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28813903
14AR_21572438_ChIP-Seq_LNCaP_Human2.27433522
15KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.24712314
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18405135
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18405135
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18023575
19* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.16991976
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13062188
21ZNF263_19887448_ChIP-Seq_K562_Human2.08938935
22ATF3_27146783_Chip-Seq_COLON_Human2.07669817
23* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07133247
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07011101
25ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human2.06656592
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05084382
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04430135
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03553161
29SMAD_19615063_ChIP-ChIP_OVARY_Human2.03175158
30ESR1_21235772_ChIP-Seq_MCF-7_Human2.01601186
31FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human2.01572914
32* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.01094129
33SOX2_20726797_ChIP-Seq_SW620_Human2.00005134
34TP63_17297297_ChIP-ChIP_HaCaT_Human10.5319027
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.94438814
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92374028
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.91996469
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.91710467
39* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91263248
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.87385855
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86401423
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.86044371
43DROSHA_22980978_ChIP-Seq_HELA_Human1.84054411
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.81295998
45* RARB_27405468_Chip-Seq_BRAIN_Mouse1.80989406
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79403203
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75526681
48CLOCK_20551151_ChIP-Seq_293T_Human1.73418052
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.72204387
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66866439
51TAF15_26573619_Chip-Seq_HEK293_Human1.65392080
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.64417001
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62684813
54RACK7_27058665_Chip-Seq_MCF-7_Human1.61152003
55ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.60859918
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60614912
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59560697
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58346034
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58268803
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55432115
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54758087
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54632019
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54256282
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.53858349
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53384598
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52473766
67CJUN_26792858_Chip-Seq_BT549_Human1.51004465
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45047936
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44795749
70AR_21909140_ChIP-Seq_LNCAP_Human1.43235098
71REST_21632747_ChIP-Seq_MESCs_Mouse1.41672876
72* TP63_23658742_ChIP-Seq_EP156T_Human1.41609580
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40880732
74GATA6_25053715_ChIP-Seq_YYC3_Human1.38987274
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.36172613
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34796085
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.33505875
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33389838
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32966873
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32380037
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.31836081
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30332012
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28397832
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.27619886
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26040509
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25350562
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.25300505
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24441621
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22711347
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.22678848
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22653284
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21706091
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20773812
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20228139
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19574792
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19479007
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19198142
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.18620757
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.17587496
100* KLF5_25053715_ChIP-Seq_YYC3_Human1.16714903
101* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16630203
102AHR_22903824_ChIP-Seq_MCF-7_Human1.16514044
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16105116
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.15869456
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.14806252
106GATA4_25053715_ChIP-Seq_YYC3_Human1.14129241
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13061574
108ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12877746
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.12773990
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12564954
111NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12457392
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12457392
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10556718
114P300_19829295_ChIP-Seq_ESCs_Human1.10255253
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10169292
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10048023
117* TP53_18474530_ChIP-ChIP_U2OS_Human1.09778442
118STAT3_23295773_ChIP-Seq_U87_Human1.09730540
119SMAD4_21799915_ChIP-Seq_A2780_Human1.08778858
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08569849
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08228516
122EP300_21415370_ChIP-Seq_HL-1_Mouse1.08158087
123ER_23166858_ChIP-Seq_MCF-7_Human1.07799402
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07430487
125VDR_22108803_ChIP-Seq_LS180_Human1.06072749
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05564715
127* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05258466
128RING1B_27294783_Chip-Seq_ESCs_Mouse1.02362680
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02051138
130SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01463436
131LXR_22158963_ChIP-Seq_LIVER_Mouse1.00991558
132TP53_22127205_ChIP-Seq_IMR90_Human1.00811377
133* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00563502
134RING1B_27294783_Chip-Seq_NPCs_Mouse1.00250497
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99640666
136* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99225074
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98976177
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98917883
139IRF8_22096565_ChIP-ChIP_GC-B_Human0.98308041
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.97920593
141GATA3_24758297_ChIP-Seq_MCF-7_Human0.96407217
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95396182
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94654788
144* FOXA2_19822575_ChIP-Seq_HepG2_Human0.94446464
145* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94014158
146BRD4_25478319_ChIP-Seq_HGPS_Human0.93130180
147* TP53_16413492_ChIP-PET_HCT116_Human0.93033159
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.92708215
149TRIM28_21343339_ChIP-Seq_HEK293_Human0.92440249
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91386507
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91262820
152POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91102519
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91047976
154* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90914062
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.90613020
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.90005904
157PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89787440
158FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88949193
159* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88826150
160* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88045757
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.87850601
162PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87232695
163* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87015694
164NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86688199
165* TCF4_23295773_ChIP-Seq_U87_Human0.86652344
166AR_25329375_ChIP-Seq_VCAP_Human0.86463273
167TBX20_22328084_ChIP-Seq_HEART_Mouse0.86247542
168TBX20_22080862_ChIP-Seq_HEART_Mouse0.86247542
169IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85837939
170RUNX2_22187159_ChIP-Seq_PCA_Human0.85136302
171BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84953890
172DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84861833
173WT1_19549856_ChIP-ChIP_CCG9911_Human0.84820252
174DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84582985
175IRF8_21731497_ChIP-ChIP_J774_Mouse0.84427406
176RXR_22158963_ChIP-Seq_LIVER_Mouse0.84290819
177TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84077206
178FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83933016
179RXR_22108803_ChIP-Seq_LS180_Human0.83620651
180TCF4_18268006_ChIP-ChIP_LS174T_Human0.81377735
181MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81352063
182PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80983340
183KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79351790
184KDM2B_26808549_Chip-Seq_K562_Human0.78295767
185KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75990542
186TCF7_22412390_ChIP-Seq_EML_Mouse0.75927980
187ELF5_23300383_ChIP-Seq_T47D_Human0.75456977
188TP63_22573176_ChIP-Seq_HFKS_Human0.74944713
189NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74224092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.35672726
2MP0000920_abnormal_myelination3.99952122
3MP0003880_abnormal_central_pattern3.68994423
4MP0004859_abnormal_synaptic_plasticity3.57348439
5MP0003453_abnormal_keratinocyte_physiol3.22387938
6MP0003566_abnormal_cell_adhesion3.09179125
7MP0004270_analgesia3.02791537
8MP0003690_abnormal_glial_cell2.88263616
9MP0003941_abnormal_skin_development2.81924936
10MP0005023_abnormal_wound_healing2.70242178
11MP0004272_abnormal_basement_membrane2.69617084
12MP0003329_amyloid_beta_deposits2.67324500
13MP0001216_abnormal_epidermal_layer2.58751334
14MP0001486_abnormal_startle_reflex2.56472913
15MP0003635_abnormal_synaptic_transmissio2.52950784
16MP0002060_abnormal_skin_morphology2.45265512
17MP0002064_seizures2.41946213
18MP0004885_abnormal_endolymph2.38733351
19MP0003705_abnormal_hypodermis_morpholog2.36861676
20MP0009745_abnormal_behavioral_response2.33872934
21MP0002272_abnormal_nervous_system2.31949749
22MP0001529_abnormal_vocalization2.30209474
23MP0008260_abnormal_autophagy2.29707455
24MP0005423_abnormal_somatic_nervous2.28853604
25MP0004264_abnormal_extraembryonic_tissu2.16717883
26MP0005501_abnormal_skin_physiology2.15588370
27MP0002063_abnormal_learning/memory/cond2.10332180
28MP0002877_abnormal_melanocyte_morpholog2.06539867
29MP0010352_gastrointestinal_tract_polyps2.03668199
30MP0003950_abnormal_plasma_membrane2.03396589
31MP0005409_darkened_coat_color2.00343705
32MP0004947_skin_inflammation1.99898683
33MP0005164_abnormal_response_to1.90441023
34MP0004742_abnormal_vestibular_system1.87219516
35MP0001849_ear_inflammation1.86017038
36MP0000858_altered_metastatic_potential1.84620442
37MP0002572_abnormal_emotion/affect_behav1.82174590
38MP0003091_abnormal_cell_migration1.81828610
39MP0003634_abnormal_glial_cell1.80299062
40MP0009046_muscle_twitch1.79209717
41MP0000778_abnormal_nervous_system1.74689544
42MP0001905_abnormal_dopamine_level1.72488734
43MP0004142_abnormal_muscle_tone1.72273294
44MP0000678_abnormal_parathyroid_gland1.71131774
45MP0002098_abnormal_vibrissa_morphology1.68864347
46MP0003300_gastrointestinal_ulcer1.68843041
47MP0003633_abnormal_nervous_system1.57481327
48MP0003632_abnormal_nervous_system1.57368048
49MP0002734_abnormal_mechanical_nocicepti1.55602721
50MP0005085_abnormal_gallbladder_physiolo1.54039897
51MP0000604_amyloidosis1.52572392
52MP0003631_nervous_system_phenotype1.51721603
53* MP0010771_integument_phenotype1.49717387
54MP0006082_CNS_inflammation1.48091975
55MP0001485_abnormal_pinna_reflex1.43955971
56MP0002229_neurodegeneration1.43812863
57MP0009785_altered_susceptibility_to1.43330174
58MP0001968_abnormal_touch/_nociception1.38788208
59MP0001440_abnormal_grooming_behavior1.38489486
60MP0001177_atelectasis1.38428949
61MP0000579_abnormal_nail_morphology1.38129271
62MP0003303_peritoneal_inflammation1.37451079
63MP0003195_calcinosis1.37326049
64MP0003436_decreased_susceptibility_to1.35339403
65MP0000955_abnormal_spinal_cord1.35169273
66MP0000383_abnormal_hair_follicle1.34577764
67MP0001970_abnormal_pain_threshold1.33591520
68MP0002139_abnormal_hepatobiliary_system1.33234900
69MP0003828_pulmonary_edema1.31903637
70MP0000377_abnormal_hair_follicle1.31423298
71MP0008569_lethality_at_weaning1.31342053
72MP0005451_abnormal_body_composition1.29878824
73MP0005646_abnormal_pituitary_gland1.29796596
74MP0004883_abnormal_blood_vessel1.28318407
75* MP0010678_abnormal_skin_adnexa1.28147198
76MP0009053_abnormal_anal_canal1.28077616
77MP0005360_urolithiasis1.27771520
78MP0002733_abnormal_thermal_nociception1.27156934
79MP0004043_abnormal_pH_regulation1.25989315
80MP0002796_impaired_skin_barrier1.25003856
81MP0008875_abnormal_xenobiotic_pharmacok1.23321311
82MP0004782_abnormal_surfactant_physiolog1.22301079
83MP0005171_absent_coat_pigmentation1.20799544
84MP0000462_abnormal_digestive_system1.20681659
85MP0002067_abnormal_sensory_capabilities1.20217153
86MP0005386_behavior/neurological_phenoty1.19964289
87MP0004924_abnormal_behavior1.19964289
88MP0003075_altered_response_to1.19946366
89MP0002882_abnormal_neuron_morphology1.19351267
90MP0002066_abnormal_motor_capabilities/c1.18958024
91MP0009780_abnormal_chondrocyte_physiolo1.18558448
92MP0005076_abnormal_cell_differentiation1.17396334
93MP0005257_abnormal_intraocular_pressure1.14959873
94MP0002090_abnormal_vision1.14919507
95MP0002148_abnormal_hypersensitivity_rea1.14558122
96MP0004381_abnormal_hair_follicle1.11872401
97MP0000627_abnormal_mammary_gland1.10891625
98MP0005551_abnormal_eye_electrophysiolog1.10264401
99MP0009931_abnormal_skin_appearance1.08018966
100MP0000537_abnormal_urethra_morphology1.07623057
101MP0005275_abnormal_skin_tensile1.06906344
102MP0005410_abnormal_fertilization1.06471704
103MP0003724_increased_susceptibility_to1.05017377
104MP0002557_abnormal_social/conspecific_i1.04609026
105MP0002332_abnormal_exercise_endurance1.04604709
106MP0005165_increased_susceptibility_to1.04458526
107MP0001501_abnormal_sleep_pattern1.04331860
108MP0005058_abnormal_lysosome_morphology1.03203022
109MP0003183_abnormal_peptide_metabolism1.03103149
110MP0003136_yellow_coat_color1.02210481
111MP0005166_decreased_susceptibility_to1.01794488
112MP0009840_abnormal_foam_cell0.99876437
113MP0003806_abnormal_nucleotide_metabolis0.98596052
114MP0002736_abnormal_nociception_after0.98585597
115MP0001963_abnormal_hearing_physiology0.96626436
116MP0002419_abnormal_innate_immunity0.95831772
117MP0001299_abnormal_eye_distance/0.92888779
118MP0002118_abnormal_lipid_homeostasis0.92289193
119MP0005248_abnormal_Harderian_gland0.91295026
120MP0010155_abnormal_intestine_physiology0.91233040
121MP0001346_abnormal_lacrimal_gland0.90358558
122MP0002896_abnormal_bone_mineralization0.89962812
123MP0005167_abnormal_blood-brain_barrier0.89895771
124MP0010234_abnormal_vibrissa_follicle0.89367333
125MP0001191_abnormal_skin_condition0.85056864
126MP0001915_intracranial_hemorrhage0.84259336
127MP0004811_abnormal_neuron_physiology0.83948299
128MP0002735_abnormal_chemical_nociception0.83890509
129MP0008874_decreased_physiological_sensi0.83874514
130MP0001502_abnormal_circadian_rhythm0.83756514
131MP0003448_altered_tumor_morphology0.83619133
132MP0001666_abnormal_nutrient_absorption0.83228173
133MP0005621_abnormal_cell_physiology0.82424465
134MP0001533_abnormal_skeleton_physiology0.81090462
135MP0003191_abnormal_cellular_cholesterol0.80046362
136MP0004134_abnormal_chest_morphology0.79448285
137MP0002152_abnormal_brain_morphology0.78858414
138MP0003656_abnormal_erythrocyte_physiolo0.78790956
139MP0005365_abnormal_bile_salt0.77833955
140MP0002184_abnormal_innervation0.77805626
141MP0000467_abnormal_esophagus_morphology0.77690318
142MP0001348_abnormal_lacrimal_gland0.77248767
143* MP0000647_abnormal_sebaceous_gland0.77228425
144MP0003252_abnormal_bile_duct0.76821770
145MP0004510_myositis0.76093440
146MP0005623_abnormal_meninges_morphology0.75985129
147MP0004858_abnormal_nervous_system0.75536621
148MP0002752_abnormal_somatic_nervous0.75261542
149MP0005584_abnormal_enzyme/coenzyme_acti0.74604227
150MP0005645_abnormal_hypothalamus_physiol0.74311159
151MP0002998_abnormal_bone_remodeling0.73351719
152MP0004233_abnormal_muscle_weight0.73199634
153MP0002138_abnormal_hepatobiliary_system0.72813920
154MP0004185_abnormal_adipocyte_glucose0.72216416
155MP0005025_abnormal_response_to0.70930877
156MP0000343_altered_response_to0.70629710
157MP0000747_muscle_weakness0.70342608
158MP0002295_abnormal_pulmonary_circulatio0.69668802
159MP0002909_abnormal_adrenal_gland0.69640768
160MP0001881_abnormal_mammary_gland0.69224560
161MP0000762_abnormal_tongue_morphology0.68776024
162* MP0000367_abnormal_coat/_hair0.68770255
163MP0005464_abnormal_platelet_physiology0.68587779
164MP0001853_heart_inflammation0.67237638
165MP0002234_abnormal_pharynx_morphology0.66043834
166MP0001790_abnormal_immune_system0.65997926
167MP0005387_immune_system_phenotype0.65997926
168MP0001845_abnormal_inflammatory_respons0.64896858
169MP0002069_abnormal_eating/drinking_beha0.64835886
170MP0002089_abnormal_postnatal_growth/wei0.64363050
171MP0008872_abnormal_physiological_respon0.63533452
172MP0000566_synostosis0.63151615
173MP0000685_abnormal_immune_system0.62684316
174MP0008469_abnormal_protein_level0.61188772
175MP0004019_abnormal_vitamin_homeostasis0.60276068
176MP0002452_abnormal_antigen_presenting0.59510210
177MP0000427_abnormal_hair_cycle0.59255606
178* MP0005193_abnormal_anterior_eye0.59175262

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)6.78102626
2Milia (HP:0001056)6.64616027
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.95020723
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.95020723
5Neurofibrillary tangles (HP:0002185)5.92227106
6Plantar hyperkeratosis (HP:0007556)5.85490660
7Fragile nails (HP:0001808)5.37782662
8Thick nail (HP:0001805)5.29648984
9Abnormality of nail color (HP:0100643)5.17790841
10Abnormality of the corticospinal tract (HP:0002492)4.81115995
11Atrophic scars (HP:0001075)4.79308544
12Myokymia (HP:0002411)4.79110857
13Alopecia of scalp (HP:0002293)4.65746718
14Cerebral inclusion bodies (HP:0100314)4.51095124
15Palmoplantar hyperkeratosis (HP:0000972)4.42288443
16Nail dystrophy (HP:0008404)4.34672525
17Right ventricular cardiomyopathy (HP:0011663)4.18310915
18Palmar hyperkeratosis (HP:0010765)4.14589477
19Termporal pattern (HP:0011008)4.03875684
20Insidious onset (HP:0003587)4.03875684
21Ridged nail (HP:0001807)3.85563287
22Onion bulb formation (HP:0003383)3.81177859
23Abnormal blistering of the skin (HP:0008066)3.81162289
24Parakeratosis (HP:0001036)3.66548430
25Ankle clonus (HP:0011448)3.64678016
26Intention tremor (HP:0002080)3.57464615
27Peripheral hypomyelination (HP:0007182)3.56781191
28Supranuclear gaze palsy (HP:0000605)3.55143059
29Spastic gait (HP:0002064)3.51720353
30Scanning speech (HP:0002168)3.31013302
31Ankyloglossia (HP:0010296)3.29281005
32Hypoplasia of dental enamel (HP:0006297)3.25438371
33Pterygium (HP:0001059)3.21246405
34Dysmetria (HP:0001310)3.16762222
35Pili torti (HP:0003777)3.12689041
36Action tremor (HP:0002345)3.06383963
37Focal motor seizures (HP:0011153)3.03206952
38Axonal loss (HP:0003447)2.94335291
39Abnormality of oral frenula (HP:0000190)2.88278264
40Sensory axonal neuropathy (HP:0003390)2.77927535
41Intrahepatic cholestasis (HP:0001406)2.76294395
42Urinary urgency (HP:0000012)2.74780366
43Sparse eyelashes (HP:0000653)2.74551148
44Abnormal hair laboratory examination (HP:0003328)2.72545342
45Retinal dysplasia (HP:0007973)2.69459443
46Abnormal auditory evoked potentials (HP:0006958)2.67739534
47Selective tooth agenesis (HP:0001592)2.67698466
48Aplasia involving bones of the upper limbs (HP:0009823)2.67047725
49Aplasia of the phalanges of the hand (HP:0009802)2.67047725
50Aplasia involving bones of the extremities (HP:0009825)2.67047725
51Abnormality of placental membranes (HP:0011409)2.65076719
52Amniotic constriction ring (HP:0009775)2.65076719
53Interstitial pulmonary disease (HP:0006530)2.64491400
54Abnormality of glycolipid metabolism (HP:0010969)2.60571890
55Abnormality of liposaccharide metabolism (HP:0010968)2.60571890
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.60571890
57Fragile skin (HP:0001030)2.59343245
58Torticollis (HP:0000473)2.56016814
59Segmental peripheral demyelination/remyelination (HP:0003481)2.55568086
60Oral leukoplakia (HP:0002745)2.54656454
61Subacute progressive viral hepatitis (HP:0006572)2.53113432
62Xerostomia (HP:0000217)2.51003770
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.49550416
64Flat acetabular roof (HP:0003180)2.47949971
65Hypotrichosis (HP:0001006)2.47852083
66Abnormality of the distal phalanges of the toes (HP:0010182)2.46980629
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.44084004
68Osteolytic defects of the hand bones (HP:0009699)2.44084004
69Slow saccadic eye movements (HP:0000514)2.43364772
70Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43354409
71Lower limb muscle weakness (HP:0007340)2.41954996
72Megalencephaly (HP:0001355)2.40873867
73Clumsiness (HP:0002312)2.39865231
74Vascular calcification (HP:0004934)2.38638761
75Short nail (HP:0001799)2.37570608
76Focal seizures (HP:0007359)2.37027125
77Alacrima (HP:0000522)2.36839631
78Clonus (HP:0002169)2.36650270
79Pustule (HP:0200039)2.36505098
80Erythema (HP:0010783)2.35032435
81Coronal craniosynostosis (HP:0004440)2.33887463
82Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.32863767
83Cheilitis (HP:0100825)2.32457943
84Hammertoe (HP:0001765)2.30749991
85Natal tooth (HP:0000695)2.29528741
86Spastic tetraparesis (HP:0001285)2.26182408
87Popliteal pterygium (HP:0009756)2.25774303
88Abnormality of the salivary glands (HP:0010286)2.24337199
89Morphological abnormality of the pyramidal tract (HP:0002062)2.22940368
90Lip pit (HP:0100267)2.22110261
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.21835366
92Dysdiadochokinesis (HP:0002075)2.21064341
93Congenital ichthyosiform erythroderma (HP:0007431)2.20615495
94Periodontitis (HP:0000704)2.20261198
95Cerebral hemorrhage (HP:0001342)2.19193255
96Arterial tortuosity (HP:0005116)2.17833854
97Urinary bladder sphincter dysfunction (HP:0002839)2.17063721
98Craniofacial dystonia (HP:0012179)2.16863000
99Hypophosphatemic rickets (HP:0004912)2.16288030
100Bowel incontinence (HP:0002607)2.14893241
101Oligodontia (HP:0000677)2.11928616
102Split foot (HP:0001839)2.11205048
103Thickened helices (HP:0000391)2.10798660
104Increased circulating renin level (HP:0000848)2.09987466
105Focal dystonia (HP:0004373)2.09800860
106Aplasia cutis congenita (HP:0001057)2.07879787
107Premature loss of primary teeth (HP:0006323)2.07461930
108Trismus (HP:0000211)2.06778687
109Nuclear cataract (HP:0100018)2.05515146
110Cerebral hypomyelination (HP:0006808)2.05513908
111Amyloidosis (HP:0011034)2.05419211
112Neuronal loss in central nervous system (HP:0002529)2.05259565
113Postural instability (HP:0002172)2.03589458
114Distal sensory impairment (HP:0002936)2.01277050
115Micronodular cirrhosis (HP:0001413)2.01096356
116Hyperlipoproteinemia (HP:0010980)2.00645285
117Vertebral compression fractures (HP:0002953)2.00393791
118Peripheral demyelination (HP:0011096)1.99910390
119Cardiovascular calcification (HP:0011915)1.99369055
120Corneal erosion (HP:0200020)1.98940011
121Anxiety (HP:0000739)1.98916774
122Deep venous thrombosis (HP:0002625)1.98463605
123Malnutrition (HP:0004395)1.97972818
124Urinary incontinence (HP:0000020)1.97960110
125Abnormal large intestine physiology (HP:0012700)1.97471800
126Impaired vibration sensation in the lower limbs (HP:0002166)1.96940782
127Distal lower limb muscle weakness (HP:0009053)1.96538130
128Pheochromocytoma (HP:0002666)1.96137858
129Glucose intolerance (HP:0000833)1.95840920
130Broad face (HP:0000283)1.94812888
131Xanthomatosis (HP:0000991)1.94218449
132Decreased motor nerve conduction velocity (HP:0003431)1.92500554
133Foot dorsiflexor weakness (HP:0009027)1.92396100
134Metabolic alkalosis (HP:0200114)1.90693701
135Absent eyelashes (HP:0000561)1.89249625
136Leukodystrophy (HP:0002415)1.88537498
137Focal segmental glomerulosclerosis (HP:0000097)1.87738122
138Autoamputation (HP:0001218)1.86608888
139Advanced eruption of teeth (HP:0006288)1.85984844
140Polygenic inheritance (HP:0010982)1.84335804
141Palmoplantar keratoderma (HP:0000982)1.84244282
142Choroideremia (HP:0001139)1.83994395
143Type II lissencephaly (HP:0007260)1.83759154
144Epileptic encephalopathy (HP:0200134)1.83437606
145Mutism (HP:0002300)1.82990764
146Decreased lacrimation (HP:0000633)1.82362846
147Anteriorly placed anus (HP:0001545)1.80711368
148Abnormality of the middle phalanges of the toes (HP:0010183)1.80129349
149Ectropion (HP:0000656)1.79678768
150Abnormality of macrophages (HP:0004311)1.78684539
151Abnormality of the gastric mucosa (HP:0004295)1.78375159
152Hyperhidrosis (HP:0000975)1.77832628
153Tetraparesis (HP:0002273)1.77676434
154Carious teeth (HP:0000670)1.77269647
155Loss of speech (HP:0002371)1.76838265
156Hemiparesis (HP:0001269)1.76420097
157Turricephaly (HP:0000262)1.75694714
158Multifactorial inheritance (HP:0001426)1.75586195
159Skin ulcer (HP:0200042)1.74851048
160Glomerulosclerosis (HP:0000096)1.74558414
161Synostosis involving the elbow (HP:0003938)1.74398831
162Humeroradial synostosis (HP:0003041)1.74398831
163Abnormality of saccadic eye movements (HP:0000570)1.74108569
164Stridor (HP:0010307)1.73640403
165Woolly hair (HP:0002224)1.72694117
166Hypoplastic pelvis (HP:0008839)1.72090930
167Hypokalemic alkalosis (HP:0001949)1.71422484
168Abnormality of the foot musculature (HP:0001436)1.71328156
169Sparse scalp hair (HP:0002209)1.70816985
170Dehydration (HP:0001944)1.70815119
171Polar cataract (HP:0010696)1.70512443
172Hoarse voice (HP:0001609)1.69835274
173Recurrent bacterial skin infections (HP:0005406)1.69562915
174Spastic paraparesis (HP:0002313)1.69074413
175Hypodontia (HP:0000668)1.68618574
176Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68076792
177Broad-based gait (HP:0002136)1.67371219
178Distal upper limb amyotrophy (HP:0007149)1.67315981
179Upper limb amyotrophy (HP:0009129)1.67315981
180Confusion (HP:0001289)1.66478934
181Spastic paraplegia (HP:0001258)1.66339011
182Bone pain (HP:0002653)1.65860411
183Poikiloderma (HP:0001029)1.65718691
184Esophageal atresia (HP:0002032)1.65659241
185Hypoplasia of the uterus (HP:0000013)1.65371653
186Akinesia (HP:0002304)1.65362714
187Depression (HP:0000716)1.64548794
188Hyperventilation (HP:0002883)1.63893915
189Vascular tortuosity (HP:0004948)1.62766730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.66938827
2EPHA26.01893808
3STK394.84678897
4EPHA43.92508467
5EPHB13.31802003
6OXSR13.30536331
7MAPKAPK52.81295660
8IRAK32.76777765
9LMTK22.41743248
10PAK42.35037566
11MAP3K122.32714260
12PKN12.16314916
13NTRK12.15245266
14WNK42.02589995
15SIK32.01790424
16ERN11.98165209
17MAP3K31.96177089
18FGFR21.95746776
19BCR1.94977163
20RIPK11.88134045
21NTRK31.78156107
22LATS21.76842686
23TYRO31.73666016
24MET1.69474220
25KSR21.68045352
26MAP3K91.67912260
27MOS1.65032420
28UHMK11.63112824
29SGK2231.62132321
30SGK4941.62132321
31NME21.61979406
32TNIK1.60600203
33MARK11.58597645
34STK241.55128210
35MAP3K21.54923538
36EPHB21.54714449
37CAMK2B1.50184823
38PBK1.49334157
39SIK11.49052044
40WNK11.48791966
41CASK1.40280878
42STK101.33379553
43PAK61.33303065
44CDK191.32971577
45PIM21.29644664
46CDK51.24543769
47PRKD31.23274479
48PNCK1.19610764
49TGFBR21.18596356
50PDGFRA1.18272545
51CSNK1A1L1.17960136
52FGR1.17431450
53LIMK11.15879236
54CSNK1G21.15733329
55NEK61.15472559
56MAPK151.14798498
57CSNK1G31.14514142
58DAPK21.14474721
59NTRK21.11347758
60LATS11.10705599
61KSR11.10038736
62MAP3K131.05633798
63MARK21.05197599
64ROCK21.03551849
65CAMK2D1.02662743
66FES1.01151957
67ERBB41.01110868
68TESK11.00843529
69CAMK2A0.98332568
70MAP3K140.96582537
71PAK30.94912829
72CAMK2G0.94623564
73IRAK40.94600877
74CSNK1G10.94215449
75TRPM70.91392655
76TESK20.89346733
77PTK60.85622912
78MST40.84988808
79PDPK10.83124827
80PHKG20.83014885
81PHKG10.83014885
82PRKD10.81774516
83STK380.81022794
84MINK10.79897027
85TAOK10.77896874
86TAOK20.77638208
87CDK140.76498374
88TTN0.74592020
89TBK10.74395505
90PRKCE0.74344957
91PRPF4B0.71525232
92MAP3K60.71343202
93SMG10.71104806
94ICK0.70225433
95PRKCH0.70008483
96CLK10.69875777
97MAP3K40.69780995
98PRKCQ0.69624245
99CDK150.69428731
100CAMK1G0.69184692
101CSK0.66397005
102CAMKK10.65240967
103CDK180.64568605
104STK110.64219793
105DDR20.63604350
106FYN0.63134537
107MAP2K30.62919596
108TRIM280.61414289
109MAP2K20.61120621
110MAPK130.60962086
111RAF10.59473651
112CDK11A0.59096030
113FLT30.58449516
114MAP3K10.57146029
115TRIB30.57014598
116BMPR20.55679749
117MAP3K80.54864507
118MUSK0.54622350
119SGK10.53979593
120MAP2K40.53842389
121DMPK0.53491272
122BRAF0.52769160
123DYRK20.52739038
124LRRK20.52608407
125ZAP700.52292493
126CDK120.52082829
127RET0.51788405
128CSF1R0.51741402
129FER0.51242454
130GSK3A0.51130650
131PDK10.50206716
132ERBB30.49982552
133RIPK40.49406884
134ABL20.49039131
135ARAF0.48792216
136SCYL20.48732312
137MAPKAPK20.48407725
138CSNK1A10.45985075
139GRK50.45705131
140PTK2B0.45689691
141PINK10.45050167
142CAMKK20.44392786
143YES10.44047748
144PDGFRB0.43279155
145CAMK10.42708738
146CSNK1D0.42567006
147NEK10.41686929
148PRKG20.41331624
149PRKCZ0.40807253
150STK38L0.40419445
151PTK20.40020652
152PRKG10.39907795
153BMX0.39774284
154MYLK0.38032706
155IRAK20.37935960
156PRKCI0.36258269
157PRKD20.35020070
158EIF2AK10.30825757
159CDK60.30553030
160SGK30.29687049
161JAK30.27886127
162CDK80.27077036
163IKBKB0.25630765
164MAP3K50.25296806
165MTOR0.24772118
166JAK10.24647982
167EIF2AK30.24476567
168MAP2K60.23976759
169IRAK10.23640437
170STK30.23497834
171FGFR10.22073904
172MELK0.21259788
173ILK0.20750389

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.61070163
2Nitrogen metabolism_Homo sapiens_hsa009103.48206950
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.30269222
4Steroid biosynthesis_Homo sapiens_hsa001003.29194038
5Fatty acid elongation_Homo sapiens_hsa000623.02853916
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61745220
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58338232
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.11330555
9Ether lipid metabolism_Homo sapiens_hsa005652.04619644
10Galactose metabolism_Homo sapiens_hsa000522.02139875
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97568993
12ECM-receptor interaction_Homo sapiens_hsa045121.95166796
13Sulfur metabolism_Homo sapiens_hsa009201.84063003
14Butanoate metabolism_Homo sapiens_hsa006501.78129274
15Histidine metabolism_Homo sapiens_hsa003401.73152677
16Adherens junction_Homo sapiens_hsa045201.71932657
17Small cell lung cancer_Homo sapiens_hsa052221.70978073
18GABAergic synapse_Homo sapiens_hsa047271.69717967
19Glutamatergic synapse_Homo sapiens_hsa047241.65823251
20Legionellosis_Homo sapiens_hsa051341.65413920
21Bladder cancer_Homo sapiens_hsa052191.62610949
22TNF signaling pathway_Homo sapiens_hsa046681.59897268
23Other glycan degradation_Homo sapiens_hsa005111.59800063
24Salmonella infection_Homo sapiens_hsa051321.59156940
25Cocaine addiction_Homo sapiens_hsa050301.58162789
26Fructose and mannose metabolism_Homo sapiens_hsa000511.58014357
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.57982797
28Thyroid cancer_Homo sapiens_hsa052161.57946272
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.56428741
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56382653
31Focal adhesion_Homo sapiens_hsa045101.52577872
32Amoebiasis_Homo sapiens_hsa051461.52016618
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47621720
34Shigellosis_Homo sapiens_hsa051311.46697678
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43688156
36Morphine addiction_Homo sapiens_hsa050321.43140233
37Toxoplasmosis_Homo sapiens_hsa051451.41925178
38African trypanosomiasis_Homo sapiens_hsa051431.38901279
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37372517
40Proteoglycans in cancer_Homo sapiens_hsa052051.37222580
41Circadian entrainment_Homo sapiens_hsa047131.36904150
42Malaria_Homo sapiens_hsa051441.34272704
43Chronic myeloid leukemia_Homo sapiens_hsa052201.33653369
44Axon guidance_Homo sapiens_hsa043601.33076870
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29290606
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27999045
47Serotonergic synapse_Homo sapiens_hsa047261.25144734
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.24131421
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20850486
50* Pancreatic cancer_Homo sapiens_hsa052121.19650295
51Lysosome_Homo sapiens_hsa041421.19550476
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19249311
53Olfactory transduction_Homo sapiens_hsa047401.19029061
54Salivary secretion_Homo sapiens_hsa049701.18401987
55Osteoclast differentiation_Homo sapiens_hsa043801.18175300
56Dopaminergic synapse_Homo sapiens_hsa047281.17790263
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.17732630
58Amphetamine addiction_Homo sapiens_hsa050311.17722516
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17074738
60Nicotine addiction_Homo sapiens_hsa050331.16352857
61Vitamin B6 metabolism_Homo sapiens_hsa007501.15960439
62Hepatitis C_Homo sapiens_hsa051601.15755783
63Cholinergic synapse_Homo sapiens_hsa047251.15730138
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14519787
65Long-term depression_Homo sapiens_hsa047301.14382545
66Gastric acid secretion_Homo sapiens_hsa049711.12466813
67Apoptosis_Homo sapiens_hsa042101.11117783
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10771911
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10690332
70p53 signaling pathway_Homo sapiens_hsa041151.08514012
71Sphingolipid metabolism_Homo sapiens_hsa006001.08082788
72Renin secretion_Homo sapiens_hsa049241.05075443
73Glycosaminoglycan degradation_Homo sapiens_hsa005311.04715203
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04702766
75Arginine biosynthesis_Homo sapiens_hsa002201.04398027
76Influenza A_Homo sapiens_hsa051641.03204363
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02788280
78NF-kappa B signaling pathway_Homo sapiens_hsa040641.02185149
79VEGF signaling pathway_Homo sapiens_hsa043701.00953565
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00857846
81Starch and sucrose metabolism_Homo sapiens_hsa005001.00341561
82Bile secretion_Homo sapiens_hsa049760.98868964
83Fatty acid metabolism_Homo sapiens_hsa012120.98679109
84Pertussis_Homo sapiens_hsa051330.98561364
85Long-term potentiation_Homo sapiens_hsa047200.98102133
86Synaptic vesicle cycle_Homo sapiens_hsa047210.97895010
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97269735
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.96957050
89Phenylalanine metabolism_Homo sapiens_hsa003600.96836955
90Tuberculosis_Homo sapiens_hsa051520.94570383
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94540146
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92603792
93Linoleic acid metabolism_Homo sapiens_hsa005910.91876349
94Gap junction_Homo sapiens_hsa045400.87209565
95Dorso-ventral axis formation_Homo sapiens_hsa043200.87118065
96Leishmaniasis_Homo sapiens_hsa051400.83637588
97Circadian rhythm_Homo sapiens_hsa047100.82155732
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82152078
99Acute myeloid leukemia_Homo sapiens_hsa052210.81558533
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.81531751
101Pentose phosphate pathway_Homo sapiens_hsa000300.81032975
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80849384
103Prion diseases_Homo sapiens_hsa050200.79689449
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77380638
105Propanoate metabolism_Homo sapiens_hsa006400.77116382
106Measles_Homo sapiens_hsa051620.76180301
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.76049507
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75088612
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74405521
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73587267
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72942154
112Insulin secretion_Homo sapiens_hsa049110.72372086
113Tight junction_Homo sapiens_hsa045300.72335793
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71374509
115Hepatitis B_Homo sapiens_hsa051610.71188308
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.70984396
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.70600286
118Arginine and proline metabolism_Homo sapiens_hsa003300.70557068
119Pancreatic secretion_Homo sapiens_hsa049720.69938379
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69583402
121Chemical carcinogenesis_Homo sapiens_hsa052040.68595294
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68436201
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68364326
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.66139538
125HIF-1 signaling pathway_Homo sapiens_hsa040660.65984438
126Endometrial cancer_Homo sapiens_hsa052130.65305654
127Ovarian steroidogenesis_Homo sapiens_hsa049130.64576359
128GnRH signaling pathway_Homo sapiens_hsa049120.64471357
129N-Glycan biosynthesis_Homo sapiens_hsa005100.63278099
130Oxytocin signaling pathway_Homo sapiens_hsa049210.62064211
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61656957
132Phagosome_Homo sapiens_hsa041450.61608992
133cAMP signaling pathway_Homo sapiens_hsa040240.61278168
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61021076
135MicroRNAs in cancer_Homo sapiens_hsa052060.60859964
136Insulin signaling pathway_Homo sapiens_hsa049100.60777221
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59897223
138* Renal cell carcinoma_Homo sapiens_hsa052110.59717323
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59617611
140Mineral absorption_Homo sapiens_hsa049780.58686754
141Fatty acid biosynthesis_Homo sapiens_hsa000610.57567222
142Peroxisome_Homo sapiens_hsa041460.57374290
143beta-Alanine metabolism_Homo sapiens_hsa004100.56571477
144ABC transporters_Homo sapiens_hsa020100.56531643
145Ras signaling pathway_Homo sapiens_hsa040140.56392656
146Complement and coagulation cascades_Homo sapiens_hsa046100.56093660
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55921016
148Calcium signaling pathway_Homo sapiens_hsa040200.55801600
149PPAR signaling pathway_Homo sapiens_hsa033200.55474090
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55105801
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54345215
152Insulin resistance_Homo sapiens_hsa049310.53927332
153Jak-STAT signaling pathway_Homo sapiens_hsa046300.53276065
154Endocytosis_Homo sapiens_hsa041440.52865855
155Tryptophan metabolism_Homo sapiens_hsa003800.52625112
156* Pathways in cancer_Homo sapiens_hsa052000.51810933
157Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50580063
158Notch signaling pathway_Homo sapiens_hsa043300.50546755
159Taste transduction_Homo sapiens_hsa047420.50296267
160PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50249457
161Fat digestion and absorption_Homo sapiens_hsa049750.50183472
162Hematopoietic cell lineage_Homo sapiens_hsa046400.49346738
163Tyrosine metabolism_Homo sapiens_hsa003500.49198688
164FoxO signaling pathway_Homo sapiens_hsa040680.47872315
165Vibrio cholerae infection_Homo sapiens_hsa051100.47528349
166Retinol metabolism_Homo sapiens_hsa008300.46895613
167Collecting duct acid secretion_Homo sapiens_hsa049660.46748296
168Vitamin digestion and absorption_Homo sapiens_hsa049770.46351385
169Choline metabolism in cancer_Homo sapiens_hsa052310.46220341
170Inositol phosphate metabolism_Homo sapiens_hsa005620.45933458
171Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44560694
172Chemokine signaling pathway_Homo sapiens_hsa040620.44327284
173Fatty acid degradation_Homo sapiens_hsa000710.44000437
174* ErbB signaling pathway_Homo sapiens_hsa040120.43845485
175Prolactin signaling pathway_Homo sapiens_hsa049170.43562804
176Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43488153
177Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43190158
178Neurotrophin signaling pathway_Homo sapiens_hsa047220.42804684
179Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41863708
180Melanogenesis_Homo sapiens_hsa049160.41801629
181Adipocytokine signaling pathway_Homo sapiens_hsa049200.40586733
182Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40129637

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