TGFB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)4.43730845
2hemidesmosome assembly (GO:0031581)4.16054736
3notochord development (GO:0030903)4.04015944
4* collagen fibril organization (GO:0030199)3.81401888
5regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.76053145
6endocardial cushion morphogenesis (GO:0003203)3.75433855
7chondrocyte proliferation (GO:0035988)3.75091052
8mesenchyme morphogenesis (GO:0072132)3.69336087
9sequestering of extracellular ligand from receptor (GO:0035581)3.67443498
10retina vasculature morphogenesis in camera-type eye (GO:0061299)3.58647815
11substrate-dependent cell migration (GO:0006929)3.49996427
12wound healing, spreading of epidermal cells (GO:0035313)3.48390540
13cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.40949882
14renal filtration (GO:0097205)3.40554386
15* regulation of transforming growth factor beta2 production (GO:0032909)3.38751643
16desmosome organization (GO:0002934)3.23446326
17skin morphogenesis (GO:0043589)3.23195487
18cell-substrate junction assembly (GO:0007044)3.21447118
19negative regulation of cartilage development (GO:0061037)3.17741278
20regulation of cardioblast proliferation (GO:0003264)3.15706584
21regulation of secondary heart field cardioblast proliferation (GO:0003266)3.15706584
22tongue development (GO:0043586)3.13389281
23cochlea morphogenesis (GO:0090103)3.04534587
24wound healing, spreading of cells (GO:0044319)3.04454398
25embryonic skeletal joint morphogenesis (GO:0060272)3.03516991
26venous blood vessel morphogenesis (GO:0048845)3.03493525
27positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.02771617
28G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.00095461
29vascular smooth muscle contraction (GO:0014829)2.99452240
30* cartilage condensation (GO:0001502)2.97577862
31* cell aggregation (GO:0098743)2.97577862
32positive regulation of guanylate cyclase activity (GO:0031284)2.95915892
33* regulation of cardioblast differentiation (GO:0051890)2.93829081
34negative regulation of hormone metabolic process (GO:0032351)2.93363344
35negative regulation of hormone biosynthetic process (GO:0032353)2.93363344
36chondrocyte development (GO:0002063)2.91049606
37regulation of chemokine-mediated signaling pathway (GO:0070099)2.90408994
38keratan sulfate catabolic process (GO:0042340)2.88651597
39regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.88412538
40* generation of neurons (GO:0048699)2.87800044
41atrial septum morphogenesis (GO:0060413)2.86891519
42heart valve formation (GO:0003188)2.85049702
43pericardium development (GO:0060039)2.83408607
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.82273225
45negative regulation of smooth muscle cell differentiation (GO:0051151)2.82055372
46axon extension (GO:0048675)2.81274551
47branching involved in salivary gland morphogenesis (GO:0060445)2.80739871
48tonic smooth muscle contraction (GO:0014820)2.80115139
49Golgi transport vesicle coating (GO:0048200)2.79318658
50COPI coating of Golgi vesicle (GO:0048205)2.79318658
51neural crest cell development (GO:0014032)2.79284733
52bone trabecula formation (GO:0060346)2.79224760
53regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.77660252
54positive regulation of osteoblast proliferation (GO:0033690)2.76677214
55glomerular filtration (GO:0003094)2.76632463
56limb bud formation (GO:0060174)2.76254783
57positive regulation of odontogenesis (GO:0042482)2.76215067
58regulation of establishment of planar polarity (GO:0090175)2.74919694
59atrioventricular valve morphogenesis (GO:0003181)2.74682607
60positive regulation of cartilage development (GO:0061036)2.74564910
61myoblast migration (GO:0051451)2.74517826
62regulation of cardiac muscle cell differentiation (GO:2000725)2.73727932
63collagen metabolic process (GO:0032963)2.73462994
64substrate adhesion-dependent cell spreading (GO:0034446)2.73271114
65positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.73239853
66vascular endothelial growth factor signaling pathway (GO:0038084)2.73069047
67* cardiac epithelial to mesenchymal transition (GO:0060317)2.72299152
68collagen catabolic process (GO:0030574)2.71513417
69protein retention in ER lumen (GO:0006621)2.71281589
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70803363
71negative regulation of keratinocyte proliferation (GO:0010839)2.70199113
72regulation of heart morphogenesis (GO:2000826)2.69215800
73type B pancreatic cell development (GO:0003323)2.68551535
74lateral sprouting from an epithelium (GO:0060601)2.67978474
75negative chemotaxis (GO:0050919)2.67867269
76positive regulation of chondrocyte differentiation (GO:0032332)2.66745688
77artery smooth muscle contraction (GO:0014824)2.65336188
78relaxation of smooth muscle (GO:0044557)2.65208794
79negative regulation of protein localization to cell surface (GO:2000009)2.64855012
80extracellular fibril organization (GO:0043206)2.64014711
81fibroblast migration (GO:0010761)2.63997620
82myoblast fusion (GO:0007520)2.61930306
83mesenchymal cell development (GO:0014031)2.61730176
84cardiac right ventricle morphogenesis (GO:0003215)2.59975628
85paraxial mesoderm development (GO:0048339)2.59964101
86heart valve morphogenesis (GO:0003179)2.59606381
87regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.59486181
88extracellular regulation of signal transduction (GO:1900115)2.59101966
89extracellular negative regulation of signal transduction (GO:1900116)2.59101966
90regulation of axon extension involved in axon guidance (GO:0048841)2.58436011
91glycoprotein catabolic process (GO:0006516)2.58066114
92nephron tubule formation (GO:0072079)2.57879694
93neuron projection extension (GO:1990138)2.56900505
94fat-soluble vitamin biosynthetic process (GO:0042362)2.56315339
95organ induction (GO:0001759)2.56182718
96adherens junction assembly (GO:0034333)2.56175628
97smooth muscle cell differentiation (GO:0051145)2.56132801
98regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.54448091
99negative regulation of striated muscle cell apoptotic process (GO:0010664)2.54416065
100regulation of cartilage development (GO:0061035)2.54349963
101multicellular organismal macromolecule metabolic process (GO:0044259)2.54322875
102negative regulation of embryonic development (GO:0045992)2.53883705
103endodermal cell differentiation (GO:0035987)2.53541256
104negative regulation of catenin import into nucleus (GO:0035414)2.53019036
105sarcomere organization (GO:0045214)2.51630106
106peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.50101823
107multicellular organismal metabolic process (GO:0044236)2.49792002
108regulation of guanylate cyclase activity (GO:0031282)2.49223562
109hippo signaling (GO:0035329)2.49185272
110epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.48714218
111cardiac myofibril assembly (GO:0055003)2.47580985
112regulation of female gonad development (GO:2000194)2.47187096
113metanephric mesenchyme development (GO:0072075)2.46989258
114positive regulation of mesenchymal cell proliferation (GO:0002053)2.46616661
115muscle cell migration (GO:0014812)2.44046528
116multicellular organismal catabolic process (GO:0044243)2.43324188
117regulation of steroid hormone biosynthetic process (GO:0090030)2.40705106
118uterus development (GO:0060065)2.39744004
119negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.38998385
120cartilage development (GO:0051216)2.38695085
121planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37703159
122positive regulation of respiratory burst (GO:0060267)2.37326019
123vitamin catabolic process (GO:0009111)2.36685426
124fat-soluble vitamin catabolic process (GO:0042363)2.36685426
125outer ear morphogenesis (GO:0042473)2.35637627
126* positive regulation of epithelial to mesenchymal transition (GO:0010718)2.35464888
127outflow tract septum morphogenesis (GO:0003148)2.34463656
128craniofacial suture morphogenesis (GO:0097094)2.33953580
129* epithelial to mesenchymal transition (GO:0001837)2.33948240
130axon extension involved in axon guidance (GO:0048846)2.33841650
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.33841650
132regulation of chondrocyte differentiation (GO:0032330)2.31859249
133basement membrane organization (GO:0071711)2.31715223
134regulation of apoptotic cell clearance (GO:2000425)2.31169876
135smooth muscle tissue development (GO:0048745)2.30830346
136negative regulation of complement activation (GO:0045916)2.30794944
137regulation of mesenchymal cell proliferation (GO:0010464)2.30313278
138mesodermal cell differentiation (GO:0048333)2.28139785
139kidney mesenchyme development (GO:0072074)2.28052696
140extracellular matrix disassembly (GO:0022617)2.27826810
141aorta morphogenesis (GO:0035909)2.27796353
142negative regulation of chondrocyte differentiation (GO:0032331)2.26912030
143photoreceptor cell differentiation (GO:0046530)2.26759686
144eye photoreceptor cell differentiation (GO:0001754)2.26759686
145protein heterotrimerization (GO:0070208)2.26659726
146* positive regulation of stem cell differentiation (GO:2000738)2.25794449
147ventricular cardiac muscle cell development (GO:0055015)2.25031437
148lymphangiogenesis (GO:0001946)2.24990206
149stem cell development (GO:0048864)2.24392447
150cGMP biosynthetic process (GO:0006182)2.24289242
151embryonic forelimb morphogenesis (GO:0035115)2.23340342
152negative regulation of homotypic cell-cell adhesion (GO:0034111)2.23186058
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23076992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.46281091
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84962291
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.43441063
4* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.31721278
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.31117761
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28710581
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22690679
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22690679
9* EED_16625203_ChIP-ChIP_MESCs_Mouse2.09985034
10* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.07566852
11* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03228454
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03000670
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96676481
14ESR1_20079471_ChIP-ChIP_T-47D_Human1.95746143
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92238243
16AR_21572438_ChIP-Seq_LNCaP_Human1.89291186
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88969656
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88021390
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87412580
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86359093
21GBX2_23144817_ChIP-Seq_PC3_Human1.85133382
22EZH2_22144423_ChIP-Seq_EOC_Human1.80364215
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.77664785
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74671749
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72794452
26CJUN_26792858_Chip-Seq_BT549_Human1.71305090
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.68480683
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68475992
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67660912
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.66433746
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62892311
32* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59916825
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59890204
34* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59719603
35* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59719603
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58657003
37* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57314124
38* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51374580
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50065392
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49545227
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48403713
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47496530
43* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.47126575
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.43855605
45TP53_18474530_ChIP-ChIP_U2OS_Human1.43145150
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.40958998
47* ISL1_27105846_Chip-Seq_CPCs_Mouse1.40744579
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40421890
49* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38462073
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38156839
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37168899
52SMAD4_21799915_ChIP-Seq_A2780_Human1.36198797
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36010649
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.35249872
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33132431
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32881451
57* EZH2_27294783_Chip-Seq_ESCs_Mouse1.31743273
58* ESR2_21235772_ChIP-Seq_MCF-7_Human1.29157320
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28864934
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28551172
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27126127
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25337023
63* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24854469
64* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24673556
65* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24673556
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24650515
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24595503
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23665789
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23603676
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23599644
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23225142
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23184149
73AHR_22903824_ChIP-Seq_MCF-7_Human1.20995697
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.20405381
75* GATA2_21666600_ChIP-Seq_HMVEC_Human1.20377341
76* TBX20_22328084_ChIP-Seq_HEART_Mouse1.19671934
77* TBX20_22080862_ChIP-Seq_HEART_Mouse1.19671934
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19458161
79* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19064163
80* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18676918
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.18565411
82FUS_26573619_Chip-Seq_HEK293_Human1.18483004
83BCAT_22108803_ChIP-Seq_LS180_Human1.18393502
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18281073
85* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17574794
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17245182
87* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15829156
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.15447548
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14929887
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14331029
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13155264
92* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13095476
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.12023374
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11964565
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11430957
96* AR_25329375_ChIP-Seq_VCAP_Human1.09885335
97* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08643039
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08409411
99TP53_16413492_ChIP-PET_HCT116_Human1.08063877
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07692101
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07633937
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06881210
103* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06822605
104* P300_19829295_ChIP-Seq_ESCs_Human1.06376159
105STAT3_23295773_ChIP-Seq_U87_Human1.05817921
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05807274
107* RING1B_27294783_Chip-Seq_ESCs_Mouse1.05627118
108CLOCK_20551151_ChIP-Seq_293T_Human1.05603667
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05587259
110* TP53_20018659_ChIP-ChIP_R1E_Mouse1.04454068
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04213007
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.02984469
113ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02814872
114POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01816988
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01188600
116AR_21909140_ChIP-Seq_LNCAP_Human1.01137017
117DROSHA_22980978_ChIP-Seq_HELA_Human1.00953506
118BRD4_25478319_ChIP-Seq_HGPS_Human1.00831388
119* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00669104
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00472691
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00358797
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99460932
123* SOX2_20726797_ChIP-Seq_SW620_Human0.99058847
124SOX2_21211035_ChIP-Seq_LN229_Gbm0.98682100
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98196868
126* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97301554
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97140050
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97012317
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96479503
130TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94720138
131TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94182306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.17445358
2MP0009384_cardiac_valve_regurgitation2.76920619
3MP0005503_abnormal_tendon_morphology2.71197330
4MP0004272_abnormal_basement_membrane2.65085207
5MP0002249_abnormal_larynx_morphology2.60529302
6MP0006054_spinal_hemorrhage2.45686697
7MP0002282_abnormal_trachea_morphology2.44694306
8MP0010368_abnormal_lymphatic_system2.41149588
9MP0010030_abnormal_orbit_morphology2.37365306
10MP0005257_abnormal_intraocular_pressure2.33920270
11* MP0009250_abnormal_appendicular_skeleto2.08907730
12MP0005275_abnormal_skin_tensile2.07313989
13MP0005508_abnormal_skeleton_morphology1.99023701
14MP0003941_abnormal_skin_development1.87531523
15MP0005623_abnormal_meninges_morphology1.86919024
16MP0003385_abnormal_body_wall1.86884699
17MP0002254_reproductive_system_inflammat1.85152074
18MP0003705_abnormal_hypodermis_morpholog1.84478867
19MP0008004_abnormal_stomach_pH1.82428092
20MP0000049_abnormal_middle_ear1.80905549
21MP0001958_emphysema1.77666166
22MP0000534_abnormal_ureter_morphology1.77641507
23MP0003879_abnormal_hair_cell1.74751991
24MP0005377_hearing/vestibular/ear_phenot1.72555656
25MP0003878_abnormal_ear_physiology1.72555656
26MP0000566_synostosis1.69236563
27MP0005248_abnormal_Harderian_gland1.67304533
28MP0003942_abnormal_urinary_system1.62497615
29MP0003279_aneurysm1.61375612
30MP0000163_abnormal_cartilage_morphology1.60839469
31MP0003937_abnormal_limbs/digits/tail_de1.57326996
32MP0001299_abnormal_eye_distance/1.53081227
33MP0001346_abnormal_lacrimal_gland1.49089976
34MP0005023_abnormal_wound_healing1.48726471
35MP0003123_paternal_imprinting1.48585500
36MP0004134_abnormal_chest_morphology1.47783180
37MP0003566_abnormal_cell_adhesion1.47379151
38* MP0003755_abnormal_palate_morphology1.44726817
39MP0000767_abnormal_smooth_muscle1.39406684
40MP0001485_abnormal_pinna_reflex1.38347157
41MP0002102_abnormal_ear_morphology1.37404086
42MP0009053_abnormal_anal_canal1.36912545
43MP0002653_abnormal_ependyma_morphology1.36152870
44* MP0002115_abnormal_skeleton_extremities1.36045864
45* MP0000026_abnormal_inner_ear1.34315819
46MP0000762_abnormal_tongue_morphology1.33464022
47* MP0002116_abnormal_craniofacial_bone1.31024969
48MP0002233_abnormal_nose_morphology1.30968070
49MP0002060_abnormal_skin_morphology1.30341248
50MP0004084_abnormal_cardiac_muscle1.30273056
51MP0000749_muscle_degeneration1.29267528
52MP0001270_distended_abdomen1.28515466
53MP0003115_abnormal_respiratory_system1.27820723
54MP0000428_abnormal_craniofacial_morphol1.24310060
55MP0002877_abnormal_melanocyte_morpholog1.23763265
56MP0002932_abnormal_joint_morphology1.23145851
57MP0000613_abnormal_salivary_gland1.22898194
58MP0000751_myopathy1.21801297
59MP0004510_myositis1.21771254
60* MP0003935_abnormal_craniofacial_develop1.21593173
61MP0009780_abnormal_chondrocyte_physiolo1.19739084
62* MP0002109_abnormal_limb_morphology1.17307407
63MP0002697_abnormal_eye_size1.15252511
64MP0003121_genomic_imprinting1.14152474
65MP0001963_abnormal_hearing_physiology1.13482499
66MP0001879_abnormal_lymphatic_vessel1.12923959
67MP0000432_abnormal_head_morphology1.12897648
68MP0002295_abnormal_pulmonary_circulatio1.11846906
69MP0002837_dystrophic_cardiac_calcinosis1.11215882
70MP0003938_abnormal_ear_development1.11033014
71MP0003329_amyloid_beta_deposits1.09814940
72* MP0005197_abnormal_uvea_morphology1.06933322
73MP0004036_abnormal_muscle_relaxation1.05841129
74MP0004484_altered_response_of1.05549320
75* MP0002113_abnormal_skeleton_development1.05447769
76MP0003091_abnormal_cell_migration1.05106571
77MP0010352_gastrointestinal_tract_polyps1.03574629
78MP0005409_darkened_coat_color1.02736686
79MP0002108_abnormal_muscle_morphology1.02081887
80MP0004087_abnormal_muscle_fiber1.01979078
81MP0000681_abnormal_thyroid_gland1.01658519
82MP0000759_abnormal_skeletal_muscle1.01084364
83MP0001915_intracranial_hemorrhage1.00270248
84MP0000467_abnormal_esophagus_morphology0.98502656
85MP0004145_abnormal_muscle_electrophysio0.98053825
86MP0005551_abnormal_eye_electrophysiolog0.97741461
87MP0000733_abnormal_muscle_development0.97357563
88MP0000537_abnormal_urethra_morphology0.96668138
89MP0005620_abnormal_muscle_contractility0.96332645
90MP0003122_maternal_imprinting0.95204577
91MP0005330_cardiomyopathy0.93929102
92MP0000678_abnormal_parathyroid_gland0.93867772
93MP0006072_abnormal_retinal_apoptosis0.93517823
94MP0003950_abnormal_plasma_membrane0.92763088
95MP0004233_abnormal_muscle_weight0.92252083
96MP0005390_skeleton_phenotype0.91507608
97MP0002089_abnormal_postnatal_growth/wei0.91359046
98MP0002933_joint_inflammation0.90591750
99MP0002896_abnormal_bone_mineralization0.89957342
100MP0003646_muscle_fatigue0.89952177
101* MP0005193_abnormal_anterior_eye0.87945093
102MP0003567_abnormal_fetal_cardiomyocyte0.87913817
103MP0004883_abnormal_blood_vessel0.87377369
104MP0005595_abnormal_vascular_smooth0.87304282
105MP0006138_congestive_heart_failure0.86498420
106* MP0001286_abnormal_eye_development0.86060636
107MP0010386_abnormal_urinary_bladder0.85789995
108MP0002177_abnormal_outer_ear0.85514143
109MP0002128_abnormal_blood_circulation0.85016705
110MP0002972_abnormal_cardiac_muscle0.84212514
111MP0000013_abnormal_adipose_tissue0.82747116
112MP0000516_abnormal_urinary_system0.81061645
113MP0005367_renal/urinary_system_phenotyp0.81061645
114MP0005187_abnormal_penis_morphology0.80993910
115MP0008789_abnormal_olfactory_epithelium0.80640041
116MP0006292_abnormal_olfactory_placode0.80075637
117MP0008775_abnormal_heart_ventricle0.80054581
118MP0000462_abnormal_digestive_system0.79939223
119MP0002127_abnormal_cardiovascular_syste0.79327681
120* MP0002925_abnormal_cardiovascular_devel0.78887341
121MP0001849_ear_inflammation0.78741770
122MP0001340_abnormal_eyelid_morphology0.78090185
123MP0000750_abnormal_muscle_regeneration0.77500204
124MP0002234_abnormal_pharynx_morphology0.77487729
125* MP0010630_abnormal_cardiac_muscle0.76720707
126MP0005171_absent_coat_pigmentation0.76309787
127MP0003453_abnormal_keratinocyte_physiol0.75889448
128* MP0001614_abnormal_blood_vessel0.75635571
129* MP0002114_abnormal_axial_skeleton0.74408369
130MP0000579_abnormal_nail_morphology0.73728171
131MP0000778_abnormal_nervous_system0.71900426
132* MP0001177_atelectasis0.71410259

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)4.88473987
2Vitreoretinal degeneration (HP:0000655)4.08309079
3Aortic aneurysm (HP:0004942)4.04411536
4Hypoplastic ischia (HP:0003175)3.83362700
5Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.77393618
6Premature rupture of membranes (HP:0001788)3.74739899
7Abnormality of the ischium (HP:0003174)3.67127307
8Bladder diverticulum (HP:0000015)3.63805393
9* Aortic dissection (HP:0002647)3.59430658
10Protrusio acetabuli (HP:0003179)3.48610401
11Shallow orbits (HP:0000586)3.46079792
12Irregular epiphyses (HP:0010582)3.20326838
13Ankle contracture (HP:0006466)3.13473926
14Neonatal short-limb short stature (HP:0008921)3.08512198
15Cervical subluxation (HP:0003308)3.03627743
16Peritonitis (HP:0002586)2.92390625
17* Vascular tortuosity (HP:0004948)2.87989377
18* Arterial tortuosity (HP:0005116)2.83227208
19Infantile muscular hypotonia (HP:0008947)2.82478659
20Genu recurvatum (HP:0002816)2.75297890
21Hip contracture (HP:0003273)2.73988863
22Mixed hearing impairment (HP:0000410)2.69466686
23Abnormality of the pubic bones (HP:0003172)2.64678158
24Cerebral aneurysm (HP:0004944)2.62507870
25Flat capital femoral epiphysis (HP:0003370)2.62400099
26Broad metatarsal (HP:0001783)2.60438732
27Aplasia involving bones of the extremities (HP:0009825)2.60195396
28Aplasia involving bones of the upper limbs (HP:0009823)2.60195396
29Aplasia of the phalanges of the hand (HP:0009802)2.60195396
30Ectopia lentis (HP:0001083)2.58887757
31Abnormality of dentin (HP:0010299)2.51176056
32Type 1 muscle fiber predominance (HP:0003803)2.46611105
33Tarsal synostosis (HP:0008368)2.43132912
34Limited hip movement (HP:0008800)2.41936602
35Wrist flexion contracture (HP:0001239)2.39541590
36Overgrowth (HP:0001548)2.38052706
37Synostosis involving bones of the lower limbs (HP:0009138)2.32900475
38Synostosis involving bones of the feet (HP:0009140)2.32900475
39Bowel diverticulosis (HP:0005222)2.28996129
40Pterygium (HP:0001059)2.27956097
41Mitral regurgitation (HP:0001653)2.27693027
42Abnormality of the calcaneus (HP:0008364)2.26520603
43Calcaneovalgus deformity (HP:0001848)2.23914473
44Mild short stature (HP:0003502)2.23676818
45Follicular hyperkeratosis (HP:0007502)2.21075111
46Abnormality of the middle phalanges of the toes (HP:0010183)2.18628139
47Osteoarthritis (HP:0002758)2.17553575
48Soft skin (HP:0000977)2.17298102
49Broad face (HP:0000283)2.17291576
50Cupped ribs (HP:0000887)2.12624175
51Short hallux (HP:0010109)2.12237789
52Pulmonary artery stenosis (HP:0004415)2.11783969
53Deformed tarsal bones (HP:0008119)2.10695886
54Ventricular tachycardia (HP:0004756)2.08956626
55* Spondylolisthesis (HP:0003302)2.08516517
56Coronal craniosynostosis (HP:0004440)2.07473902
57Flat acetabular roof (HP:0003180)2.06567759
58Synostosis of carpal bones (HP:0005048)2.06387806
59Delayed epiphyseal ossification (HP:0002663)2.06186722
60Knee flexion contracture (HP:0006380)2.02399540
61Syringomyelia (HP:0003396)2.02346526
62Spinal cord lesions (HP:0100561)2.02346526
63Abnormality of incisor morphology (HP:0011063)2.01192091
64Abnormality of the proximal phalanges of the hand (HP:0009834)2.00144772
65Bell-shaped thorax (HP:0001591)1.99497765
66Atrophic scars (HP:0001075)1.99078334
67Hallux valgus (HP:0001822)1.97278016
68Lip pit (HP:0100267)1.95258719
69Morphological abnormality of the middle ear (HP:0008609)1.93547989
70Absent frontal sinuses (HP:0002688)1.93400308
71Broad long bones (HP:0005622)1.92728919
72Disproportionate tall stature (HP:0001519)1.91629775
73Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91088380
74Abnormality of abdominal situs (HP:0011620)1.90942858
75Abdominal situs inversus (HP:0003363)1.90942858
76Deviation of the hallux (HP:0010051)1.90569994
77Broad thumb (HP:0011304)1.90501056
78Synostosis involving the elbow (HP:0003938)1.90291098
79Humeroradial synostosis (HP:0003041)1.90291098
80Radial bowing (HP:0002986)1.89455617
81Carpal synostosis (HP:0009702)1.88050216
82Osteolytic defects of the hand bones (HP:0009699)1.88040343
83Osteolytic defects of the phalanges of the hand (HP:0009771)1.88040343
84Aortic regurgitation (HP:0001659)1.87913375
85Spinal rigidity (HP:0003306)1.87875249
86Elbow flexion contracture (HP:0002987)1.87697714
87Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87614776
88Vertebral arch anomaly (HP:0008438)1.86275861
89Abnormality of the 2nd finger (HP:0004100)1.85521026
90Scapular winging (HP:0003691)1.85372195
91Severe Myopia (HP:0011003)1.85346588
92Vertebral compression fractures (HP:0002953)1.84708282
93Camptodactyly of toe (HP:0001836)1.83763553
94Broad phalanx (HP:0006009)1.83334486
95Enlarged epiphyses (HP:0010580)1.82861020
96Abnormal delivery (HP:0001787)1.82488472
97Short nail (HP:0001799)1.82350272
98Hypoplasia of the iris (HP:0007676)1.82331222
99Aplasia/Hypoplasia of the hallux (HP:0008362)1.81983961
100Mitral stenosis (HP:0001718)1.81170037
101Abnormality of the calf musculature (HP:0001430)1.80928612
102Ulnar bowing (HP:0003031)1.80674332
103Wide anterior fontanel (HP:0000260)1.80490938
104Aneurysm (HP:0002617)1.79940734
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.79440941
106Genu varum (HP:0002970)1.79387419
107Wormian bones (HP:0002645)1.78744862
108Mesomelia (HP:0003027)1.78433795
109Broad ribs (HP:0000885)1.78374261
110Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78023146
111Absent epiphyses (HP:0010577)1.78023146
112Aplasia/Hypoplasia of the fibula (HP:0006492)1.77585108
113Hyperextensible skin (HP:0000974)1.76729061
114Abnormal vertebral ossification (HP:0100569)1.76397250
115* Mitral valve prolapse (HP:0001634)1.76102018
116Dilatation of the ascending aorta (HP:0005111)1.75897357
117Blue sclerae (HP:0000592)1.75801960
118Vertebral clefting (HP:0008428)1.75479262
119Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.74358610
120Abnormality of femoral epiphyses (HP:0006499)1.74358610
121Pulmonic stenosis (HP:0001642)1.73881541
122Joint laxity (HP:0001388)1.72880289
123Thin ribs (HP:0000883)1.72587502
124Platyspondyly (HP:0000926)1.72546467
125Right ventricular cardiomyopathy (HP:0011663)1.71787241
126Round ear (HP:0100830)1.71186456
127Abnormality of the acetabulum (HP:0003170)1.69098041
128Oligodactyly (HP:0012165)1.68220144
129Mildly elevated creatine phosphokinase (HP:0008180)1.67664442
130Abnormality of the lower motor neuron (HP:0002366)1.67411961
131Fibular hypoplasia (HP:0003038)1.67173370
132Bronchomalacia (HP:0002780)1.66467095
133Exostoses (HP:0100777)1.66457518
134Fragile skin (HP:0001030)1.66230485
135Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65919734
136Short 4th metacarpal (HP:0010044)1.65919734
137Tibial bowing (HP:0002982)1.65845314
138Venous insufficiency (HP:0005293)1.64809777
139Retinal detachment (HP:0000541)1.63669533
140Patent foramen ovale (HP:0001655)1.62734189
141Vertebral hypoplasia (HP:0008417)1.58807778
142Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.58807778
143Venous abnormality (HP:0002624)1.58466098
144Renal duplication (HP:0000075)1.57958420
145Increased mean platelet volume (HP:0011877)1.57236493
146Biconcave vertebral bodies (HP:0004586)1.56216970
147Bowing of the arm (HP:0006488)1.55610653
148Bowed forearm bones (HP:0003956)1.55610653
149Coxa vara (HP:0002812)1.55560743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.89077343
2LATS14.37102039
3STK38L3.78106165
4PKN23.68658249
5FLT32.98783802
6LATS22.94465320
7EPHA22.53775108
8MYLK2.53031902
9DMPK2.50261402
10EPHB22.15122015
11MUSK2.06980118
12NUAK12.06347606
13MAP3K92.00798420
14TTN1.97580028
15KSR21.89313054
16ERBB41.85532192
17MAP3K61.81866460
18EPHA31.75670768
19STK31.73378736
20TESK11.69384835
21PAK31.68516753
22PRKD31.61484859
23MAP3K121.53574417
24TRPM71.51871335
25RAF11.48405078
26MAPKAPK31.47464613
27TGFBR21.42396022
28FER1.41066838
29PNCK1.40824020
30STK381.40757757
31PDGFRA1.39848496
32PLK21.35585080
33KSR11.29528789
34MAP3K131.27463136
35ROCK11.26903006
36PAK61.25287717
37PTK2B1.22179337
38PAK41.19462597
39STK241.12954473
40RIPK11.10598623
41ARAF1.08060696
42PTK21.07095681
43EPHA41.07090092
44TAOK11.06933856
45MOS1.03808788
46CASK1.03556511
47MET1.02776421
48PAK21.00298641
49PIK3CA0.97089461
50MELK0.94475475
51BRAF0.91552321
52TAOK30.90500087
53ERBB30.88820590
54NTRK10.86006408
55WNK10.85706224
56ILK0.83979493
57OBSCN0.83226783
58ROCK20.83196569
59CDK80.82552368
60EEF2K0.81109512
61NLK0.80996533
62CDK60.80934061
63LIMK10.77239132
64LMTK20.76837262
65NME10.76775980
66MTOR0.73992915
67MST1R0.73118702
68MAPK130.72289889
69BCR0.69431965
70CDC42BPA0.69114603
71MAPK70.68835860
72CDK90.65860997
73MAP3K30.65375523
74TRIB30.65204070
75MARK10.65136903
76ICK0.62298492
77CAMK2D0.62099134
78PRKD20.61687316
79CAMK2B0.60355347
80CAMK2A0.57336768
81SCYL20.56810276
82TIE10.55902887
83PRKCE0.55005420
84FGFR10.54848736
85MAP3K100.54771594
86CAMK2G0.54517880
87MAP2K10.53636771
88SGK20.51536264
89PRKAA20.51261959
90MAP3K40.50912242
91MARK20.50676923
92BMX0.48088164
93RPS6KA20.47909980
94DYRK1A0.47765385
95PLK40.45438796
96PIK3CG0.44479029
97MAP3K70.44053758
98NEK90.41492799
99AKT30.41303403
100SIK10.40831739
101DYRK20.40798314
102DAPK30.40796020
103PDGFRB0.40567513
104NTRK20.40194906
105RET0.39467306
106CDK120.39375463
107PRPF4B0.38961643
108CAMK1G0.38512713
109EPHB10.37694363
110TTK0.36342523
111FGFR20.36195058
112PHKG20.35777421
113PHKG10.35777421
114MKNK20.35718816
115SGK2230.35048473
116SGK4940.35048473
117CDK30.34377917
118RPS6KB20.33834632
119PLK30.33828486
120PRKCZ0.33476982
121PTK60.33273953
122PRKG10.32682452
123IGF1R0.32631577
124MAPK120.31309428
125MAP3K20.30443380
126GSK3A0.28986144
127SGK30.28608359
128MAPK100.27329515
129INSR0.26630558
130TAF10.25912685
131SRC0.25871623
132YES10.24873297
133CDK180.24852822
134PRKG20.23174138
135CDK150.22908272
136NTRK30.22394463

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.05767145
2* TGF-beta signaling pathway_Homo sapiens_hsa043502.49167503
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.31432173
4Focal adhesion_Homo sapiens_hsa045102.16160979
5* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.14206068
6* Dilated cardiomyopathy_Homo sapiens_hsa054142.11130529
7Adherens junction_Homo sapiens_hsa045202.08633926
8* Hippo signaling pathway_Homo sapiens_hsa043901.98856921
9Circadian rhythm_Homo sapiens_hsa047101.81182677
10Basal cell carcinoma_Homo sapiens_hsa052171.73310498
11Protein digestion and absorption_Homo sapiens_hsa049741.60356645
12* Proteoglycans in cancer_Homo sapiens_hsa052051.46650761
13Other glycan degradation_Homo sapiens_hsa005111.45703735
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43862812
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.42143680
16Wnt signaling pathway_Homo sapiens_hsa043101.39786826
17Melanogenesis_Homo sapiens_hsa049161.39619376
18Ovarian steroidogenesis_Homo sapiens_hsa049131.36136899
19GnRH signaling pathway_Homo sapiens_hsa049121.35411679
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34561808
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34469928
22Axon guidance_Homo sapiens_hsa043601.33338261
23Dorso-ventral axis formation_Homo sapiens_hsa043201.29248786
24Hedgehog signaling pathway_Homo sapiens_hsa043401.24937245
25Tight junction_Homo sapiens_hsa045301.24383457
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.23521256
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22616098
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22446735
29* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21139940
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18325249
31Ras signaling pathway_Homo sapiens_hsa040141.17817115
32Rap1 signaling pathway_Homo sapiens_hsa040151.16443541
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.16290316
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15585773
35Oxytocin signaling pathway_Homo sapiens_hsa049211.15321009
36* Amoebiasis_Homo sapiens_hsa051461.13720366
37Circadian entrainment_Homo sapiens_hsa047131.11121669
38* MicroRNAs in cancer_Homo sapiens_hsa052061.10908286
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10411742
40Nicotine addiction_Homo sapiens_hsa050331.05480125
41Thyroid cancer_Homo sapiens_hsa052161.05024790
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04749060
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.04600374
44* Pancreatic cancer_Homo sapiens_hsa052121.03825792
45cAMP signaling pathway_Homo sapiens_hsa040241.02875226
46Melanoma_Homo sapiens_hsa052181.01626173
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00366888
48Small cell lung cancer_Homo sapiens_hsa052220.99483684
49Thyroid hormone synthesis_Homo sapiens_hsa049180.99094861
50Salivary secretion_Homo sapiens_hsa049700.98620893
51GABAergic synapse_Homo sapiens_hsa047270.98382391
52Long-term depression_Homo sapiens_hsa047300.98336494
53* Colorectal cancer_Homo sapiens_hsa052100.97721997
54Olfactory transduction_Homo sapiens_hsa047400.97183211
55Glioma_Homo sapiens_hsa052140.96607926
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96341646
57Gap junction_Homo sapiens_hsa045400.95814911
58Serotonergic synapse_Homo sapiens_hsa047260.95670833
59Renin secretion_Homo sapiens_hsa049240.95598209
60Glutamatergic synapse_Homo sapiens_hsa047240.94992584
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94441560
62Gastric acid secretion_Homo sapiens_hsa049710.94229280
63Estrogen signaling pathway_Homo sapiens_hsa049150.92377467
64Choline metabolism in cancer_Homo sapiens_hsa052310.92009629
65Endometrial cancer_Homo sapiens_hsa052130.91069900
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89369879
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88707375
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88663160
69* Pathways in cancer_Homo sapiens_hsa052000.88136242
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88018066
71Notch signaling pathway_Homo sapiens_hsa043300.87019686
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86491805
73Prion diseases_Homo sapiens_hsa050200.86097765
74Prostate cancer_Homo sapiens_hsa052150.84242467
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83592600
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83152684
77ErbB signaling pathway_Homo sapiens_hsa040120.80208264
78Cholinergic synapse_Homo sapiens_hsa047250.79980310
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.79078834
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.79034784
81Bladder cancer_Homo sapiens_hsa052190.78243991
82Sphingolipid metabolism_Homo sapiens_hsa006000.76863084
83Morphine addiction_Homo sapiens_hsa050320.76709171
84* Renal cell carcinoma_Homo sapiens_hsa052110.75862854
85Dopaminergic synapse_Homo sapiens_hsa047280.73134035
86* MAPK signaling pathway_Homo sapiens_hsa040100.72670417
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70779614
88Insulin secretion_Homo sapiens_hsa049110.70503271
89VEGF signaling pathway_Homo sapiens_hsa043700.68769286
90Amphetamine addiction_Homo sapiens_hsa050310.67373189
91Long-term potentiation_Homo sapiens_hsa047200.66894821
92* Chronic myeloid leukemia_Homo sapiens_hsa052200.66562300
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.66250834
94Calcium signaling pathway_Homo sapiens_hsa040200.64677350
95Arachidonic acid metabolism_Homo sapiens_hsa005900.63054493
96Non-small cell lung cancer_Homo sapiens_hsa052230.62616058
97Oocyte meiosis_Homo sapiens_hsa041140.62472417
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60062786
99Vibrio cholerae infection_Homo sapiens_hsa051100.59720813
100Sulfur metabolism_Homo sapiens_hsa009200.57872151
101p53 signaling pathway_Homo sapiens_hsa041150.57792321
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57678156
103Phototransduction_Homo sapiens_hsa047440.57654731
104Insulin signaling pathway_Homo sapiens_hsa049100.57033745
105N-Glycan biosynthesis_Homo sapiens_hsa005100.56747648
106Cocaine addiction_Homo sapiens_hsa050300.54407975
107* Endocytosis_Homo sapiens_hsa041440.52399398
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52030902
109* Cell cycle_Homo sapiens_hsa041100.50651369
110Viral myocarditis_Homo sapiens_hsa054160.50155903
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49552712
112Mineral absorption_Homo sapiens_hsa049780.49215062
113* FoxO signaling pathway_Homo sapiens_hsa040680.49108131
114Cardiac muscle contraction_Homo sapiens_hsa042600.47233279
115Glucagon signaling pathway_Homo sapiens_hsa049220.46750745
116HIF-1 signaling pathway_Homo sapiens_hsa040660.46053463
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42867213
118Platelet activation_Homo sapiens_hsa046110.41391765
119Inositol phosphate metabolism_Homo sapiens_hsa005620.40716113
120Salmonella infection_Homo sapiens_hsa051320.40608222
121AMPK signaling pathway_Homo sapiens_hsa041520.39366727
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39139880
123Shigellosis_Homo sapiens_hsa051310.39111829
124Lysine degradation_Homo sapiens_hsa003100.38181290
125Pancreatic secretion_Homo sapiens_hsa049720.35708935
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35264022
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34851685

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