TGFB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.30305014
2chondrocyte proliferation (GO:0035988)5.88550148
3protein heterotrimerization (GO:0070208)5.63316564
4sequestering of extracellular ligand from receptor (GO:0035581)5.52074761
5cell adhesion mediated by integrin (GO:0033627)5.22122269
6negative regulation of fatty acid transport (GO:2000192)5.18445850
7endodermal cell differentiation (GO:0035987)5.12177942
8skin morphogenesis (GO:0043589)5.03539599
9bone trabecula formation (GO:0060346)4.79630244
10regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.71385391
11positive regulation of endothelial cell apoptotic process (GO:2000353)4.44054773
12endocardial cushion development (GO:0003197)4.43274502
13plasma membrane repair (GO:0001778)4.35984245
14peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.27474766
15wound healing, spreading of epidermal cells (GO:0035313)4.23650001
16keratan sulfate catabolic process (GO:0042340)4.22714046
17epithelial cell-cell adhesion (GO:0090136)4.00794433
18collagen metabolic process (GO:0032963)3.95216643
19collagen catabolic process (GO:0030574)3.89681509
20negative regulation of chondrocyte differentiation (GO:0032331)3.81146307
21extracellular fibril organization (GO:0043206)3.79460637
22cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.76063540
23multicellular organismal macromolecule metabolic process (GO:0044259)3.71946532
24positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.69580387
25wound healing, spreading of cells (GO:0044319)3.68617544
26axon extension involved in axon guidance (GO:0048846)3.64837346
27neuron projection extension involved in neuron projection guidance (GO:1902284)3.64837346
28peptidyl-proline hydroxylation (GO:0019511)3.63725290
29extracellular matrix assembly (GO:0085029)3.62424359
30multicellular organismal catabolic process (GO:0044243)3.58839540
31metanephric mesenchyme development (GO:0072075)3.54259688
32multicellular organismal metabolic process (GO:0044236)3.54007221
33extracellular matrix disassembly (GO:0022617)3.49813658
34dermatan sulfate biosynthetic process (GO:0030208)3.49432152
35negative regulation of smooth muscle cell migration (GO:0014912)3.48839935
36basement membrane organization (GO:0071711)3.47366738
37atrioventricular valve morphogenesis (GO:0003181)3.46746074
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.44582732
39lung lobe morphogenesis (GO:0060463)3.43927483
40fibril organization (GO:0097435)3.40367950
41mesenchymal-epithelial cell signaling (GO:0060638)3.39155426
42regulation of tight junction assembly (GO:2000810)3.34818055
43kidney mesenchyme development (GO:0072074)3.34265846
44glomerular filtration (GO:0003094)3.33924995
45stress fiber assembly (GO:0043149)3.33588814
46positive regulation of osteoblast proliferation (GO:0033690)3.30326107
47cellular response to vitamin (GO:0071295)3.29495476
48retina vasculature morphogenesis in camera-type eye (GO:0061299)3.25140860
49hippo signaling (GO:0035329)3.23326700
50cellular response to vitamin D (GO:0071305)3.23239323
51dermatan sulfate metabolic process (GO:0030205)3.21908754
52protein localization to cell surface (GO:0034394)3.18826731
53tonic smooth muscle contraction (GO:0014820)3.18623466
54protein hydroxylation (GO:0018126)3.16112250
55positive regulation of blood vessel endothelial cell migration (GO:0043536)3.15015012
56negative regulation of cartilage development (GO:0061037)3.11046770
57apoptotic cell clearance (GO:0043277)3.10431024
58cell migration involved in heart development (GO:0060973)3.09823535
59endocrine hormone secretion (GO:0060986)3.08190292
60type B pancreatic cell proliferation (GO:0044342)3.04778691
61regulation of plasminogen activation (GO:0010755)3.04594165
62endothelial cell chemotaxis (GO:0035767)3.04072487
63negative regulation of adherens junction organization (GO:1903392)3.03686092
64negative regulation of focal adhesion assembly (GO:0051895)3.03686092
65negative regulation of cell junction assembly (GO:1901889)3.03686092
66substrate-dependent cell migration (GO:0006929)3.02644529
67glomerular basement membrane development (GO:0032836)3.01359905
68* extracellular matrix organization (GO:0030198)3.01192624
69substrate adhesion-dependent cell spreading (GO:0034446)3.00065499
70* extracellular structure organization (GO:0043062)2.99858173
71renal filtration (GO:0097205)2.97915084
72insulin-like growth factor receptor signaling pathway (GO:0048009)2.96250281
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96180574
74vascular endothelial growth factor signaling pathway (GO:0038084)2.96151009
75extracellular regulation of signal transduction (GO:1900115)2.93705473
76extracellular negative regulation of signal transduction (GO:1900116)2.93705473
77cardiac myofibril assembly (GO:0055003)2.93618876
78cell-substrate junction assembly (GO:0007044)2.92568178
79pattern specification involved in kidney development (GO:0061004)2.89730704
80positive regulation of fibroblast migration (GO:0010763)2.88598769
81G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.88101547
82regulation of cartilage development (GO:0061035)2.86861831
83regulation of integrin-mediated signaling pathway (GO:2001044)2.86529588
84prostate gland growth (GO:0060736)2.86484329
85positive regulation of macrophage activation (GO:0043032)2.86133491
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.86028122
87regulation of skeletal muscle contraction (GO:0014819)2.84735354
88chondrocyte development (GO:0002063)2.84390163
89adherens junction assembly (GO:0034333)2.83201953
90cell proliferation involved in metanephros development (GO:0072203)2.82205660
91endocardial cushion morphogenesis (GO:0003203)2.81715795
92relaxation of smooth muscle (GO:0044557)2.81060456
93embryonic cranial skeleton morphogenesis (GO:0048701)2.80867496
94myofibril assembly (GO:0030239)2.79456635
95cell migration involved in sprouting angiogenesis (GO:0002042)2.78847387
96regulation of chondrocyte differentiation (GO:0032330)2.78822999
97negative regulation of catenin import into nucleus (GO:0035414)2.77842864
98cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.77390310
99negative regulation of protein localization to cell surface (GO:2000009)2.75029990
100positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.75015370
101positive regulation of cartilage development (GO:0061036)2.71916154
102* positive regulation of epithelial to mesenchymal transition (GO:0010718)2.71072973
103actin-myosin filament sliding (GO:0033275)2.70794861
104mesodermal cell differentiation (GO:0048333)2.70393507
105regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69227975
106mesenchyme morphogenesis (GO:0072132)2.68745663
107protein targeting to plasma membrane (GO:0072661)2.68272690
108virion attachment to host cell (GO:0019062)2.67652321
109adhesion of symbiont to host cell (GO:0044650)2.67652321
110positive regulation of extracellular matrix organization (GO:1903055)2.67608050
111prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.67389021
112peripheral nervous system axon ensheathment (GO:0032292)2.66783890
113myelination in peripheral nervous system (GO:0022011)2.66783890
114regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.65348384
115camera-type eye morphogenesis (GO:0048593)2.64827116
116cell-matrix adhesion (GO:0007160)2.64529393
117cGMP biosynthetic process (GO:0006182)2.64144615
118negative regulation of embryonic development (GO:0045992)2.63739552
119artery smooth muscle contraction (GO:0014824)2.63690393
120positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.62907744
121heart valve morphogenesis (GO:0003179)2.62458388
122smooth muscle tissue development (GO:0048745)2.61631413
123trabecula formation (GO:0060343)2.61513417
124endothelial cell morphogenesis (GO:0001886)2.60662922
125positive regulation of odontogenesis (GO:0042482)2.60451770
126wound healing (GO:0042060)2.60165450
127polarized epithelial cell differentiation (GO:0030859)2.59424481
128cell-substrate adhesion (GO:0031589)2.59369710
129muscle filament sliding (GO:0030049)2.57213464
130negative regulation of cell size (GO:0045792)2.49804693
131cell proliferation involved in kidney development (GO:0072111)2.48589168
132lung vasculature development (GO:0060426)2.45246438
133sarcomere organization (GO:0045214)2.41940675
134regulation of extracellular matrix disassembly (GO:0010715)2.41815134
135chondroitin sulfate catabolic process (GO:0030207)2.36269913
136response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.35425093
137face development (GO:0060324)2.33342389
138actin-mediated cell contraction (GO:0070252)2.31109489
139regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.30253110
140outflow tract septum morphogenesis (GO:0003148)2.28923073
141positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.27224789
142cardiac muscle hypertrophy (GO:0003300)2.26655761
143organ induction (GO:0001759)2.25986014
144urinary tract smooth muscle contraction (GO:0014848)2.25129691
145regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.24650145
146regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.23711156
147negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.23599298
148epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.21983159
149striated muscle hypertrophy (GO:0014897)2.20772633
150regulation of axon extension involved in axon guidance (GO:0048841)2.17530868
151muscle hypertrophy (GO:0014896)2.17215453
152neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.15568955
153ovulation from ovarian follicle (GO:0001542)2.14482863
154myelin maintenance (GO:0043217)2.12311852
155vascular smooth muscle contraction (GO:0014829)2.12006535
156regulation of protein localization to cell surface (GO:2000008)2.11116834
157lung secretory cell differentiation (GO:0061140)2.10941889
158cyclic purine nucleotide metabolic process (GO:0052652)2.10789175
159regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.10660544
160relaxation of muscle (GO:0090075)2.10504716
161actomyosin structure organization (GO:0031032)2.09771779
162myotube cell development (GO:0014904)2.08278981
163nephron epithelium development (GO:0072009)2.07022027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.57226971
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.89374469
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.31244270
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.27091732
5CLOCK_20551151_ChIP-Seq_293T_Human2.75575116
6RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.65109269
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.58548122
8CJUN_26792858_Chip-Seq_BT549_Human2.54746169
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.38482066
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38080083
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.31934012
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.25067599
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18696977
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.14670131
15* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12622995
16* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.11913261
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.05248225
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02204879
19CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.99966678
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.99426711
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97835852
22BRD4_25478319_ChIP-Seq_HGPS_Human1.97122148
23DROSHA_22980978_ChIP-Seq_HELA_Human1.92048234
24NRF2_20460467_ChIP-Seq_MEFs_Mouse1.84032464
25NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.84032464
26GBX2_23144817_ChIP-Seq_PC3_Human1.80414025
27* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78675008
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76777602
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75640861
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.74870506
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.69841166
32EZH2_22144423_ChIP-Seq_EOC_Human1.64420689
33TP53_18474530_ChIP-ChIP_U2OS_Human1.61520364
34TP53_16413492_ChIP-PET_HCT116_Human1.60384607
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.60340856
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59561009
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59561009
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59349323
39GATA1_22025678_ChIP-Seq_K562_Human1.59179564
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56714732
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56699718
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55959397
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55499749
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55499749
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55224259
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54472526
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52764876
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.52550512
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.50638020
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50423439
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.50299346
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48831231
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46928875
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.46209448
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46106547
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44365901
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44061156
58* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43711299
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43664262
60* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.42971977
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42892658
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40585286
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.40122863
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.38368024
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.38368024
66SOX2_20726797_ChIP-Seq_SW620_Human1.37682804
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.35768218
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34812369
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34437675
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32954313
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31171427
72UBF1/2_26484160_Chip-Seq_HMECs_Human1.31033882
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28601973
74TP53_23651856_ChIP-Seq_MEFs_Mouse1.28384899
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27112945
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26549359
77MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24900296
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24849741
79AR_21572438_ChIP-Seq_LNCaP_Human1.23894093
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21899263
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21606315
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21440094
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21418216
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21013948
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20753902
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.19022816
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18826681
88TP53_22127205_ChIP-Seq_IMR90_Human1.17921123
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16676121
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16431777
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.16282149
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15558720
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.14173540
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13940051
95ATF3_27146783_Chip-Seq_COLON_Human1.13714948
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.13520127
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.13451297
98FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12845195
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10571354
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10115672
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10068978
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09664238
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09493789
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08455338
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07244793
106FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06072597
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05764302
108* RACK7_27058665_Chip-Seq_MCF-7_Human1.05572287
109RUNX1_27514584_Chip-Seq_MCF-7_Human1.04211995
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03582377
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.03507195
112SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03043627
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02646923
114* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01101808
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00345295
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99455773
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98947391
118RNF2_27304074_Chip-Seq_ESCs_Mouse0.98631606
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98564247
120KDM2B_26808549_Chip-Seq_K562_Human0.97671468
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97434251
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97391590
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96956496
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96844575
125KLF5_25053715_ChIP-Seq_YYC3_Human0.96399400
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95933719
127ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95818714
128AHR_22903824_ChIP-Seq_MCF-7_Human0.95639981
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94927043
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94048194
131EZH2_27304074_Chip-Seq_ESCs_Mouse0.93532214
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93007426
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.92078833
134TP63_23658742_ChIP-Seq_EP156T_Human0.91298611
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88929117
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.88470765
137SMAD4_21799915_ChIP-Seq_A2780_Human0.87153788
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86785664
139SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85850926
140EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82560040
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82398528
142FOXA2_19822575_ChIP-Seq_HepG2_Human0.82231803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.67728131
2MP0005503_abnormal_tendon_morphology5.14383577
3MP0005275_abnormal_skin_tensile5.14286755
4MP0003279_aneurysm3.75650434
5MP0003705_abnormal_hypodermis_morpholog3.74725912
6MP0002254_reproductive_system_inflammat3.38921542
7MP0001958_emphysema3.09573776
8MP0005623_abnormal_meninges_morphology3.06464087
9MP0009384_cardiac_valve_regurgitation2.81446446
10MP0004272_abnormal_basement_membrane2.78239184
11MP0003566_abnormal_cell_adhesion2.70151285
12MP0006054_spinal_hemorrhage2.28832759
13MP0005508_abnormal_skeleton_morphology2.15818175
14MP0010352_gastrointestinal_tract_polyps2.14252338
15MP0005257_abnormal_intraocular_pressure2.13481743
16MP0005023_abnormal_wound_healing2.01097383
17MP0003191_abnormal_cellular_cholesterol1.94223610
18MP0003091_abnormal_cell_migration1.87911487
19MP0002060_abnormal_skin_morphology1.85675571
20MP0009250_abnormal_appendicular_skeleto1.85035763
21MP0010030_abnormal_orbit_morphology1.81619737
22MP0002108_abnormal_muscle_morphology1.80741252
23MP0000013_abnormal_adipose_tissue1.74344909
24MP0003385_abnormal_body_wall1.72142768
25* MP0002295_abnormal_pulmonary_circulatio1.71210918
26MP0000733_abnormal_muscle_development1.69456326
27MP0005248_abnormal_Harderian_gland1.66333911
28MP0001542_abnormal_bone_strength1.63903564
29MP0001348_abnormal_lacrimal_gland1.62626699
30MP0008775_abnormal_heart_ventricle1.62538062
31MP0000767_abnormal_smooth_muscle1.57588441
32MP0001299_abnormal_eye_distance/1.53344202
33MP0002282_abnormal_trachea_morphology1.51423801
34MP0000751_myopathy1.48181639
35MP0001243_abnormal_dermal_layer1.45381522
36MP0002896_abnormal_bone_mineralization1.44372210
37MP0003045_fibrosis1.44287514
38MP0000462_abnormal_digestive_system1.43231816
39MP0004134_abnormal_chest_morphology1.41068913
40MP0001346_abnormal_lacrimal_gland1.35564531
41MP0000750_abnormal_muscle_regeneration1.35035058
42MP0003941_abnormal_skin_development1.31905355
43MP0000566_synostosis1.27016888
44MP0004264_abnormal_extraembryonic_tissu1.25439625
45MP0003283_abnormal_digestive_organ1.23682608
46MP0003942_abnormal_urinary_system1.22015261
47MP0005390_skeleton_phenotype1.19320031
48MP0009053_abnormal_anal_canal1.18901569
49MP0002168_other_aberrant_phenotype1.18693953
50MP0010368_abnormal_lymphatic_system1.18245193
51MP0000163_abnormal_cartilage_morphology1.17781352
52MP0004084_abnormal_cardiac_muscle1.17750408
53MP0005167_abnormal_blood-brain_barrier1.16086466
54MP0000534_abnormal_ureter_morphology1.13092483
55MP0000749_muscle_degeneration1.12964696
56MP0000003_abnormal_adipose_tissue1.12395405
57MP0004510_myositis1.12213731
58MP0002106_abnormal_muscle_physiology1.10315380
59MP0003300_gastrointestinal_ulcer1.09973831
60MP0000428_abnormal_craniofacial_morphol1.09916804
61MP0002932_abnormal_joint_morphology1.08702168
62MP0002115_abnormal_skeleton_extremities1.07870792
63MP0004087_abnormal_muscle_fiber1.06271327
64MP0004484_altered_response_of1.01296055
65MP0003646_muscle_fatigue0.99824626
66* MP0003755_abnormal_palate_morphology0.97845663
67MP0004270_analgesia0.97745421
68MP0000759_abnormal_skeletal_muscle0.96753735
69MP0002113_abnormal_skeleton_development0.96285510
70MP0009840_abnormal_foam_cell0.95564250
71MP0006138_congestive_heart_failure0.94325349
72MP0003950_abnormal_plasma_membrane0.93742255
73MP0002089_abnormal_postnatal_growth/wei0.93533378
74* MP0003115_abnormal_respiratory_system0.93050855
75MP0002249_abnormal_larynx_morphology0.90496444
76MP0002933_joint_inflammation0.88794406
77* MP0002128_abnormal_blood_circulation0.87724295
78MP0002877_abnormal_melanocyte_morpholog0.87343910
79MP0000762_abnormal_tongue_morphology0.85645322
80MP0008004_abnormal_stomach_pH0.85529834
81MP0005165_increased_susceptibility_to0.85061655
82MP0000747_muscle_weakness0.84581573
83MP0005369_muscle_phenotype0.83512059
84MP0005620_abnormal_muscle_contractility0.83278153
85MP0002127_abnormal_cardiovascular_syste0.83004080
86MP0004233_abnormal_muscle_weight0.82856523
87MP0001614_abnormal_blood_vessel0.82686662
88MP0005330_cardiomyopathy0.81955975
89MP0005595_abnormal_vascular_smooth0.81609230
90MP0000432_abnormal_head_morphology0.81018756
91MP0002998_abnormal_bone_remodeling0.79319348
92MP0002837_dystrophic_cardiac_calcinosis0.79142118
93MP0000627_abnormal_mammary_gland0.79027204
94MP0002116_abnormal_craniofacial_bone0.77653409
95MP0010386_abnormal_urinary_bladder0.76709165
96MP0002925_abnormal_cardiovascular_devel0.75108297
97MP0009780_abnormal_chondrocyte_physiolo0.75057993
98MP0010630_abnormal_cardiac_muscle0.74995507
99MP0002109_abnormal_limb_morphology0.74491291
100MP0005164_abnormal_response_to0.74417400
101MP0004145_abnormal_muscle_electrophysio0.74313365
102MP0002269_muscular_atrophy0.74183493
103* MP0003935_abnormal_craniofacial_develop0.73884241
104MP0003937_abnormal_limbs/digits/tail_de0.73686906
105MP0005076_abnormal_cell_differentiation0.73100844
106MP0001544_abnormal_cardiovascular_syste0.73052201
107MP0005385_cardiovascular_system_phenoty0.73052201
108MP0000049_abnormal_middle_ear0.72940424
109MP0000516_abnormal_urinary_system0.72921149
110MP0005367_renal/urinary_system_phenotyp0.72921149
111MP0004782_abnormal_surfactant_physiolog0.71653921
112MP0003448_altered_tumor_morphology0.71138925
113MP0003795_abnormal_bone_structure0.71073453
114MP0005187_abnormal_penis_morphology0.70164573
115MP0000538_abnormal_urinary_bladder0.70139906
116MP0000467_abnormal_esophagus_morphology0.69954560
117MP0005670_abnormal_white_adipose0.69671865
118MP0005171_absent_coat_pigmentation0.69560244
119MP0010234_abnormal_vibrissa_follicle0.68947805
120MP0002972_abnormal_cardiac_muscle0.68797402
121MP0001533_abnormal_skeleton_physiology0.68107726
122* MP0002233_abnormal_nose_morphology0.67329104
123MP0002114_abnormal_axial_skeleton0.66898616
124* MP0001177_atelectasis0.66856517
125MP0004036_abnormal_muscle_relaxation0.66834737
126MP0000537_abnormal_urethra_morphology0.66761869
127MP0001270_distended_abdomen0.65080263
128MP0005197_abnormal_uvea_morphology0.64657997
129MP0005375_adipose_tissue_phenotype0.64519294
130MP0001879_abnormal_lymphatic_vessel0.64454579
131MP0004215_abnormal_myocardial_fiber0.63229531

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.01534091
2Premature rupture of membranes (HP:0001788)7.73282034
3Aortic dissection (HP:0002647)5.38991913
4Shallow orbits (HP:0000586)4.97139134
5Atrophic scars (HP:0001075)4.90682986
6Aortic aneurysm (HP:0004942)4.56105607
7Peritonitis (HP:0002586)4.50470224
8Broad metatarsal (HP:0001783)4.26877028
9Cerebral aneurysm (HP:0004944)4.25126017
10Ankle contracture (HP:0006466)4.10931594
11Fragile skin (HP:0001030)4.04865692
12Soft skin (HP:0000977)4.03997050
13Abnormality of dentin (HP:0010299)3.98691486
14Dilatation of the ascending aorta (HP:0005111)3.96044063
15Bladder diverticulum (HP:0000015)3.91634373
16Type 1 muscle fiber predominance (HP:0003803)3.75339068
17Exercise-induced myalgia (HP:0003738)3.49496403
18Genu recurvatum (HP:0002816)3.40778187
19Neonatal short-limb short stature (HP:0008921)3.38303332
20Round ear (HP:0100830)3.31441251
21Cervical subluxation (HP:0003308)3.31125562
22Wormian bones (HP:0002645)3.24999641
23Mitral valve prolapse (HP:0001634)3.24825891
24Pulmonary artery stenosis (HP:0004415)3.21188241
25Spinal rigidity (HP:0003306)3.13756618
26Vascular tortuosity (HP:0004948)3.10304321
27* Blue sclerae (HP:0000592)3.09695333
28Increased connective tissue (HP:0009025)3.05770666
29Vertebral compression fractures (HP:0002953)3.02528689
30Biconcave vertebral bodies (HP:0004586)3.01678721
31Wrist flexion contracture (HP:0001239)3.01506538
32Infantile muscular hypotonia (HP:0008947)2.92951002
33Bowel diverticulosis (HP:0005222)2.88571225
34Overgrowth (HP:0001548)2.75697786
35Hyperextensible skin (HP:0000974)2.73731395
36Abnormality of the calf musculature (HP:0001430)2.63782835
37Abnormal delivery (HP:0001787)2.62191775
38Increased variability in muscle fiber diameter (HP:0003557)2.60441598
39Aneurysm (HP:0002617)2.57482254
40Arterial tortuosity (HP:0005116)2.54072983
41Asymmetric septal hypertrophy (HP:0001670)2.54015126
42Ulnar deviation of the wrist (HP:0003049)2.51127088
43Follicular hyperkeratosis (HP:0007502)2.47610474
44Mildly elevated creatine phosphokinase (HP:0008180)2.45032935
45Limited hip movement (HP:0008800)2.43608838
46Camptodactyly of toe (HP:0001836)2.42110142
47Abnormality of skeletal muscle fiber size (HP:0012084)2.39606679
48Muscle fiber splitting (HP:0003555)2.39579440
49Scapular winging (HP:0003691)2.34835265
50Ectopia lentis (HP:0001083)2.34310777
51Mitral regurgitation (HP:0001653)2.32691491
52Elbow flexion contracture (HP:0002987)2.31999606
53Breech presentation (HP:0001623)2.31964512
54Hypoalphalipoproteinemia (HP:0003233)2.31126634
55Lymphangioma (HP:0100764)2.29914964
56Wide anterior fontanel (HP:0000260)2.29589102
57Difficulty climbing stairs (HP:0003551)2.27779793
58Thin bony cortex (HP:0002753)2.27448856
59Deviation of the hallux (HP:0010051)2.25746522
60Abnormality of the acetabulum (HP:0003170)2.25119295
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.25033376
62Buphthalmos (HP:0000557)2.23392889
63EMG: myopathic abnormalities (HP:0003458)2.23279703
64Spondylolisthesis (HP:0003302)2.22496133
65Mesomelia (HP:0003027)2.21273668
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.20920201
67Mitral stenosis (HP:0001718)2.20594293
68Slender build (HP:0001533)2.20541377
69Calcaneovalgus deformity (HP:0001848)2.20263251
70Sudden death (HP:0001699)2.19136408
71Alopecia of scalp (HP:0002293)2.18735505
72Hallux valgus (HP:0001822)2.18501530
73Abnormality of the calcaneus (HP:0008364)2.17527003
74Tibial bowing (HP:0002982)2.16106667
75Short nail (HP:0001799)2.15673300
76Joint laxity (HP:0001388)2.13903191
77Knee flexion contracture (HP:0006380)2.12737642
78Bell-shaped thorax (HP:0001591)2.11793596
79Distal arthrogryposis (HP:0005684)2.10189536
80Broad ribs (HP:0000885)2.08663185
81Hip contracture (HP:0003273)2.08136377
82Neoplasm of the heart (HP:0100544)2.07854729
83Deformed tarsal bones (HP:0008119)2.07634609
84Increased density of long bones (HP:0006392)2.07572691
85Action tremor (HP:0002345)2.06628959
86Muscle fiber inclusion bodies (HP:0100299)2.05801810
87Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.05183164
88Popliteal pterygium (HP:0009756)2.04554753
89Tarsal synostosis (HP:0008368)2.03423602
90Facial diplegia (HP:0001349)2.02874733
91Hyporeflexia of lower limbs (HP:0002600)2.02250975
92Congenital glaucoma (HP:0001087)2.01649673
93Osteolytic defects of the hand bones (HP:0009699)1.99942177
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.99942177
95Abnormality of the peritoneum (HP:0002585)1.96509564
96Keratoconus (HP:0000563)1.96004587
97Increased corneal curvature (HP:0100692)1.96004587
98Asymmetry of the thorax (HP:0001555)1.95537259
99Abnormality of the anterior chamber (HP:0000593)1.95284701
100Osteoarthritis (HP:0002758)1.95236077
101Neck muscle weakness (HP:0000467)1.95030126
102Joint contractures involving the joints of the feet (HP:0100492)1.93403555
103Flexion contracture of toe (HP:0005830)1.93403555
104Aortic regurgitation (HP:0001659)1.90585869
105Venous abnormality (HP:0002624)1.88172216
106Abnormality of the ischium (HP:0003174)1.87727208
107Joint stiffness (HP:0001387)1.87186813
108Distal lower limb amyotrophy (HP:0008944)1.86984580
109Rib fusion (HP:0000902)1.86391240
110Mild short stature (HP:0003502)1.86335766
111* Right ventricular cardiomyopathy (HP:0011663)1.86061779
112Obstructive sleep apnea (HP:0002870)1.85603613
113Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.85119016
114Absent phalangeal crease (HP:0006109)1.83235996
115Bundle branch block (HP:0011710)1.83140029
116Hypoplastic ischia (HP:0003175)1.82655625
117Renovascular hypertension (HP:0100817)1.82298662
118Ulnar bowing (HP:0003031)1.82267926
119Akinesia (HP:0002304)1.82226705
120Upper limb amyotrophy (HP:0009129)1.81805933
121Distal upper limb amyotrophy (HP:0007149)1.81805933
122Femoral bowing (HP:0002980)1.79922675
123Broad long bones (HP:0005622)1.79823873
124Nemaline bodies (HP:0003798)1.79666730
125Morphological abnormality of the middle ear (HP:0008609)1.79295921
126Coronal craniosynostosis (HP:0004440)1.78895157
127Synostosis involving bones of the feet (HP:0009140)1.78703390
128Synostosis involving bones of the lower limbs (HP:0009138)1.78703390
129Aortic valve stenosis (HP:0001650)1.77924994
130Venous insufficiency (HP:0005293)1.77539334
131Narrow palate (HP:0000189)1.76481405
132Bronchomalacia (HP:0002780)1.72984312
133Distal lower limb muscle weakness (HP:0009053)1.72619812
134Hypoplasia of the iris (HP:0007676)1.72430911
135Osteopenia (HP:0000938)1.72148844
136Thin ribs (HP:0000883)1.71878800
137Nonimmune hydrops fetalis (HP:0001790)1.71716648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.27533774
2TIE14.04619653
3TRIB33.93925819
4DDR23.71810818
5LATS13.43851242
6PDGFRA3.16024342
7SIK12.95564354
8LATS22.92617162
9PKN22.51461350
10EPHA32.43483317
11EPHB22.26227520
12PIK3CA2.18666616
13PAK32.18337277
14DMPK2.18290573
15MARK12.10268673
16PAK22.08716671
17MYLK2.07782045
18FER1.99854764
19RIPK11.96854880
20ERN11.90826307
21TRPM71.90642773
22PIK3CG1.76649160
23PTK21.64499571
24LIMK11.57430873
25CASK1.48750000
26LMTK21.45739697
27TESK11.43502187
28BMX1.42932977
29STK38L1.34566031
30PIM21.31177381
31LRRK21.28549451
32NTRK31.28107549
33ROCK11.27128367
34PTK2B1.27124930
35PTK61.26153122
36STK31.25914740
37PDGFRB1.24789576
38AKT31.24412872
39ILK1.23637672
40CDK121.22371131
41EEF2K1.21721476
42FRK1.21293785
43MUSK1.20799008
44EPHA21.20603156
45MARK21.15315233
46EPHB11.14473901
47MOS1.13338911
48ERBB31.09073982
49PAK41.08331317
50MET1.05162464
51FGFR11.04755571
52MAP2K11.04318648
53MAPK150.99111702
54NTRK10.96468053
55CDC42BPA0.94437598
56SGK2230.92650927
57SGK4940.92650927
58MAP3K60.92292832
59HIPK20.91567395
60MTOR0.90631031
61NEK90.90468251
62ROCK20.86462274
63MAPK120.83239460
64DAPK30.83183198
65TGFBR20.82039472
66RET0.80958002
67SGK20.78568417
68MAPKAPK50.78363681
69KIT0.77467055
70NUAK10.76822578
71PRKD10.76076858
72GRK10.73627272
73FGFR20.72575340
74MAPK70.71747198
75CAMK10.71288120
76INSRR0.66719036
77PRKAA20.65823384
78FGFR30.65774781
79PRKD20.64105887
80PRKCH0.64039330
81MAPKAPK30.62137611
82MAP3K100.61514772
83MAP4K20.60546370
84INSR0.60418965
85CAMK2G0.59406935
86PAK60.57920941
87SGK30.56901351
88PRPF4B0.56097964
89RPS6KA40.55456944
90PLK20.55065368
91CDK60.55058541
92EPHA40.54782293
93WNK10.54497673
94KSR20.52992611
95ZAK0.51971885
96TGFBR10.50868023
97DYRK1B0.49590713
98STK380.48923959
99TAOK10.48104450
100NLK0.46839557
101STK390.46654020
102OBSCN0.46158464
103PRKG10.45720114
104PAK10.44637674
105CAMK1D0.43768687
106MAPK100.42383085
107PRKG20.41546560
108MAPK40.41436824
109PRKAA10.39829546
110SRC0.39679620
111PRKD30.39548756
112CAMK1G0.38964084
113RPS6KA20.38350535
114MAP3K20.38347250
115RPS6KB10.38280577
116PINK10.37850865
117CAMK2B0.37656753
118ZAP700.37369369
119MAPK130.36357262
120ABL20.36002639
121FGFR40.35439637
122CDK80.35122707
123ERBB20.33571854
124PDK40.33260107
125PDK30.33260107
126MAP3K30.31321649
127RAF10.31293324
128PRKCE0.30928076
129JAK10.30792982
130PDK20.30227671
131MAPKAPK20.30061623
132PHKG20.29840332
133PHKG10.29840332
134FLT30.29494093
135CDK140.29464298
136RPS6KB20.29443483
137ERBB40.29376010
138KSR10.28299741
139CDK150.26197066
140MAP3K70.25501284
141ADRBK10.25004398

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.24927257
2Focal adhesion_Homo sapiens_hsa045103.25796319
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.82434027
4* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.69991246
5* Dilated cardiomyopathy_Homo sapiens_hsa054142.64590963
6Proteoglycans in cancer_Homo sapiens_hsa052052.50778674
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.40728539
8Adherens junction_Homo sapiens_hsa045202.30872816
9Bladder cancer_Homo sapiens_hsa052192.26477316
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.20891278
11Protein digestion and absorption_Homo sapiens_hsa049742.14658980
12* Amoebiasis_Homo sapiens_hsa051462.14161906
13* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.91982251
14* Hippo signaling pathway_Homo sapiens_hsa043901.91188151
15Renin secretion_Homo sapiens_hsa049241.87475424
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.83420616
17* TGF-beta signaling pathway_Homo sapiens_hsa043501.78005685
18Small cell lung cancer_Homo sapiens_hsa052221.74072866
19MicroRNAs in cancer_Homo sapiens_hsa052061.74015251
20Regulation of actin cytoskeleton_Homo sapiens_hsa048101.73402681
21Basal cell carcinoma_Homo sapiens_hsa052171.63704447
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.53610864
23Tight junction_Homo sapiens_hsa045301.51884837
24Melanoma_Homo sapiens_hsa052181.47751596
25Circadian entrainment_Homo sapiens_hsa047131.46189160
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.46180373
27ABC transporters_Homo sapiens_hsa020101.45202745
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39349784
29Salivary secretion_Homo sapiens_hsa049701.37687518
30Calcium signaling pathway_Homo sapiens_hsa040201.34343438
31Pancreatic secretion_Homo sapiens_hsa049721.31424150
32Hedgehog signaling pathway_Homo sapiens_hsa043401.30981639
33Viral myocarditis_Homo sapiens_hsa054161.30961051
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30334324
35* Chronic myeloid leukemia_Homo sapiens_hsa052201.29343879
36* Malaria_Homo sapiens_hsa051441.26984915
37Shigellosis_Homo sapiens_hsa051311.22117588
38Platelet activation_Homo sapiens_hsa046111.20807864
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.20621434
40Insulin secretion_Homo sapiens_hsa049111.19848778
41Glioma_Homo sapiens_hsa052141.19368973
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15981478
43Prostate cancer_Homo sapiens_hsa052151.13395833
44Rap1 signaling pathway_Homo sapiens_hsa040151.10955809
45Complement and coagulation cascades_Homo sapiens_hsa046101.10462767
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09791426
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.09618755
48Circadian rhythm_Homo sapiens_hsa047101.08700355
49Axon guidance_Homo sapiens_hsa043601.08258690
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05718724
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05582052
52p53 signaling pathway_Homo sapiens_hsa041151.05465413
53* Pathways in cancer_Homo sapiens_hsa052001.05087287
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04998528
55Mineral absorption_Homo sapiens_hsa049781.04778366
56Wnt signaling pathway_Homo sapiens_hsa043101.04732874
57* Pancreatic cancer_Homo sapiens_hsa052121.04109934
58Melanogenesis_Homo sapiens_hsa049161.02977442
59Histidine metabolism_Homo sapiens_hsa003400.98331042
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.94904781
61Endometrial cancer_Homo sapiens_hsa052130.93027157
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91261040
63HIF-1 signaling pathway_Homo sapiens_hsa040660.90041774
64GABAergic synapse_Homo sapiens_hsa047270.88602795
65Gap junction_Homo sapiens_hsa045400.87042827
66Glutamatergic synapse_Homo sapiens_hsa047240.86782289
67Prion diseases_Homo sapiens_hsa050200.86717358
68Phagosome_Homo sapiens_hsa041450.86579235
69beta-Alanine metabolism_Homo sapiens_hsa004100.86070329
70Morphine addiction_Homo sapiens_hsa050320.85592357
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84923651
72Amphetamine addiction_Homo sapiens_hsa050310.84731194
73Salmonella infection_Homo sapiens_hsa051320.83758480
74GnRH signaling pathway_Homo sapiens_hsa049120.82329782
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.81851364
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81073072
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80292932
78VEGF signaling pathway_Homo sapiens_hsa043700.79312271
79* Toxoplasmosis_Homo sapiens_hsa051450.78864300
80Bile secretion_Homo sapiens_hsa049760.78485590
81Estrogen signaling pathway_Homo sapiens_hsa049150.77733933
82TNF signaling pathway_Homo sapiens_hsa046680.77290806
83Cholinergic synapse_Homo sapiens_hsa047250.77264759
84Cardiac muscle contraction_Homo sapiens_hsa042600.76839768
85Sphingolipid metabolism_Homo sapiens_hsa006000.76793203
86* Renal cell carcinoma_Homo sapiens_hsa052110.76777729
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76187672
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76171869
89Ovarian steroidogenesis_Homo sapiens_hsa049130.74278141
90Phenylalanine metabolism_Homo sapiens_hsa003600.73634513
91ErbB signaling pathway_Homo sapiens_hsa040120.73593091
92Oxytocin signaling pathway_Homo sapiens_hsa049210.73127236
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.72929870
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71543649
95* HTLV-I infection_Homo sapiens_hsa051660.70945988
96Insulin resistance_Homo sapiens_hsa049310.70358808
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70280923
98Lysine degradation_Homo sapiens_hsa003100.69593294
99mTOR signaling pathway_Homo sapiens_hsa041500.68810414
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68575539
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.68537649
102Ras signaling pathway_Homo sapiens_hsa040140.67307514
103Cocaine addiction_Homo sapiens_hsa050300.66804885
104Dopaminergic synapse_Homo sapiens_hsa047280.64473072
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63121562
106Vibrio cholerae infection_Homo sapiens_hsa051100.62841749
107Insulin signaling pathway_Homo sapiens_hsa049100.61198336
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60714650
109Notch signaling pathway_Homo sapiens_hsa043300.60243289
110Prolactin signaling pathway_Homo sapiens_hsa049170.60229697
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60058029
112* Endocytosis_Homo sapiens_hsa041440.59084332
113* Colorectal cancer_Homo sapiens_hsa052100.58745517
114Non-small cell lung cancer_Homo sapiens_hsa052230.58590675
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58118626
116* MAPK signaling pathway_Homo sapiens_hsa040100.55997582
117AMPK signaling pathway_Homo sapiens_hsa041520.55288603
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52133231
119Apoptosis_Homo sapiens_hsa042100.51942898
120Choline metabolism in cancer_Homo sapiens_hsa052310.51686770
121Long-term depression_Homo sapiens_hsa047300.50416882
122Nitrogen metabolism_Homo sapiens_hsa009100.50332140
123Acute myeloid leukemia_Homo sapiens_hsa052210.48866830
124* FoxO signaling pathway_Homo sapiens_hsa040680.47889374
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.44150923
126Viral carcinogenesis_Homo sapiens_hsa052030.43605863
127Thyroid cancer_Homo sapiens_hsa052160.43582836
128Thyroid hormone synthesis_Homo sapiens_hsa049180.42028903
129* Hepatitis B_Homo sapiens_hsa051610.41388442
130cAMP signaling pathway_Homo sapiens_hsa040240.39750328
131Gastric acid secretion_Homo sapiens_hsa049710.36186170
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34514764
133Dorso-ventral axis formation_Homo sapiens_hsa043200.31116768
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.31010879
135Glucagon signaling pathway_Homo sapiens_hsa049220.30839055
136Renin-angiotensin system_Homo sapiens_hsa046140.30424820

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