TGFBR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.97600139
2vascular endothelial growth factor signaling pathway (GO:0038084)5.04648348
3regulation of complement activation (GO:0030449)4.85932756
4collagen fibril organization (GO:0030199)4.84846970
5very-low-density lipoprotein particle assembly (GO:0034379)4.81483102
6regulation of protein activation cascade (GO:2000257)4.78041064
7regulation of cholesterol homeostasis (GO:2000188)4.61262620
8retina vasculature morphogenesis in camera-type eye (GO:0061299)4.54070076
9plasma lipoprotein particle assembly (GO:0034377)4.51409930
10negative regulation of protein activation cascade (GO:2000258)4.49735264
11glucocorticoid biosynthetic process (GO:0006704)4.47070810
12basement membrane organization (GO:0071711)4.41932532
13intestinal cholesterol absorption (GO:0030299)4.38574628
14protein-lipid complex assembly (GO:0065005)4.32734498
15negative regulation of fibrinolysis (GO:0051918)4.32050594
16regulation of apoptotic cell clearance (GO:2000425)4.30959531
17blood vessel maturation (GO:0001955)4.28447871
18lymph vessel development (GO:0001945)4.25198268
19cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.17939900
20glomerular basement membrane development (GO:0032836)4.13965957
21plasma lipoprotein particle clearance (GO:0034381)4.02100104
22peptidyl-glutamic acid carboxylation (GO:0017187)4.02095756
23protein carboxylation (GO:0018214)4.02095756
24sequestering of extracellular ligand from receptor (GO:0035581)3.93672249
25low-density lipoprotein particle remodeling (GO:0034374)3.93392193
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.89500240
27lymphangiogenesis (GO:0001946)3.88371736
28progesterone metabolic process (GO:0042448)3.88042649
29cholesterol efflux (GO:0033344)3.85746924
30axon extension involved in axon guidance (GO:0048846)3.82425478
31neuron projection extension involved in neuron projection guidance (GO:1902284)3.82425478
32glucocorticoid metabolic process (GO:0008211)3.80993019
33C21-steroid hormone metabolic process (GO:0008207)3.75984822
34collagen metabolic process (GO:0032963)3.72112087
35protein-lipid complex remodeling (GO:0034368)3.64611201
36macromolecular complex remodeling (GO:0034367)3.64611201
37plasma lipoprotein particle remodeling (GO:0034369)3.64611201
38cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.62273952
39chondrocyte proliferation (GO:0035988)3.60374443
40plasma lipoprotein particle organization (GO:0071827)3.59799084
41multicellular organismal macromolecule metabolic process (GO:0044259)3.58632029
42collagen catabolic process (GO:0030574)3.58154954
43protein-lipid complex subunit organization (GO:0071825)3.55164657
44regulation of fibrinolysis (GO:0051917)3.52570391
45regulation of cholesterol esterification (GO:0010872)3.49492030
46positive regulation of extracellular matrix organization (GO:1903055)3.49191750
47androgen biosynthetic process (GO:0006702)3.45745829
48positive regulation of hormone biosynthetic process (GO:0046886)3.45034002
49multicellular organismal metabolic process (GO:0044236)3.42628818
50extracellular fibril organization (GO:0043206)3.38568043
51* definitive hemopoiesis (GO:0060216)3.37395962
52complement activation, alternative pathway (GO:0006957)3.34933309
53skin morphogenesis (GO:0043589)3.34772233
54endodermal cell differentiation (GO:0035987)3.33875542
55multicellular organismal catabolic process (GO:0044243)3.33486325
56fibroblast migration (GO:0010761)3.33176173
57ovulation from ovarian follicle (GO:0001542)3.32112256
58glomerular filtration (GO:0003094)3.31366694
59blood coagulation, intrinsic pathway (GO:0007597)3.30781868
60cardiac myofibril assembly (GO:0055003)3.29994828
61high-density lipoprotein particle remodeling (GO:0034375)3.23329360
62estrogen biosynthetic process (GO:0006703)3.22464702
63bone trabecula formation (GO:0060346)3.22084401
64negative regulation of humoral immune response (GO:0002921)3.21572777
65fibril organization (GO:0097435)3.20319427
66* response to follicle-stimulating hormone (GO:0032354)3.20109429
67hemidesmosome assembly (GO:0031581)3.18492874
68intestinal absorption (GO:0050892)3.17496925
69apoptotic cell clearance (GO:0043277)3.15832065
70endocrine hormone secretion (GO:0060986)3.15563438
71low-density lipoprotein particle clearance (GO:0034383)3.13744618
72endothelial cell proliferation (GO:0001935)3.13565002
73regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.12965608
74renal filtration (GO:0097205)3.12776961
75valine metabolic process (GO:0006573)3.11006974
76cell migration involved in heart development (GO:0060973)3.10542219
77lung epithelium development (GO:0060428)3.09391150
78phagocytosis, recognition (GO:0006910)3.09036774
79positive regulation of steroid metabolic process (GO:0045940)3.08662236
80extracellular matrix disassembly (GO:0022617)3.08605170
81reverse cholesterol transport (GO:0043691)3.07497020
82regulation of plasminogen activation (GO:0010755)3.07110758
83positive regulation of hormone metabolic process (GO:0032352)3.06035165
84insulin-like growth factor receptor signaling pathway (GO:0048009)3.05760840
85cell migration involved in sprouting angiogenesis (GO:0002042)3.05512421
86diacylglycerol metabolic process (GO:0046339)3.05287899
87substrate adhesion-dependent cell spreading (GO:0034446)3.00220913
88C21-steroid hormone biosynthetic process (GO:0006700)3.00099177
89endothelial cell morphogenesis (GO:0001886)2.99766853
90venous blood vessel morphogenesis (GO:0048845)2.99133408
91epithelial cell-cell adhesion (GO:0090136)2.99097302
92positive regulation of fatty acid oxidation (GO:0046321)2.98864304
93regulation of extracellular matrix disassembly (GO:0010715)2.98783943
94regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.98776304
95regulation of steroid hormone biosynthetic process (GO:0090030)2.98737229
96lipoprotein metabolic process (GO:0042157)2.97890146
97regulation of sequestering of triglyceride (GO:0010889)2.97517461
98acylglycerol catabolic process (GO:0046464)2.94935533
99neutral lipid catabolic process (GO:0046461)2.94935533
100branching involved in salivary gland morphogenesis (GO:0060445)2.94627210
101regulation of cholesterol storage (GO:0010885)2.93703824
102triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.93591012
103cholesterol transport (GO:0030301)2.93027495
104sterol transport (GO:0015918)2.93027495
105hippo signaling (GO:0035329)2.91199299
106cell adhesion mediated by integrin (GO:0033627)2.90563757
107positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.90266457
108regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.87468160
109embryonic retina morphogenesis in camera-type eye (GO:0060059)2.87150639
110blood vessel endothelial cell migration (GO:0043534)2.86389654
111negative regulation of norepinephrine secretion (GO:0010700)2.85604088
112growth hormone receptor signaling pathway (GO:0060396)2.85431298
113smooth muscle tissue development (GO:0048745)2.83158753
114cell-substrate junction assembly (GO:0007044)2.82937519
115cell proliferation involved in metanephros development (GO:0072203)2.82592222
116extracellular matrix assembly (GO:0085029)2.82413147
117triglyceride catabolic process (GO:0019433)2.82381111
118positive regulation of epithelial to mesenchymal transition (GO:0010718)2.80859287
119mesenchymal-epithelial cell signaling (GO:0060638)2.79931433
120positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.79923815
121sprouting angiogenesis (GO:0002040)2.79767586
122positive regulation of fatty acid beta-oxidation (GO:0032000)2.78729267
123vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.78484243
124brown fat cell differentiation (GO:0050873)2.77365498
125regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.76794493
126vitamin transmembrane transport (GO:0035461)2.76648942
127regulation of humoral immune response (GO:0002920)2.76151928
128glomerular visceral epithelial cell development (GO:0072015)2.73562128
129cellular response to growth hormone stimulus (GO:0071378)2.72962563
130positive regulation of p38MAPK cascade (GO:1900745)2.71738361
131regulation of cholesterol biosynthetic process (GO:0045540)2.71013461
132positive regulation of lipid storage (GO:0010884)2.70653435
133fatty acid homeostasis (GO:0055089)2.70116707
134cellular response to antibiotic (GO:0071236)2.70027837
135* trabecula formation (GO:0060343)2.69949544
136cellular response to epinephrine stimulus (GO:0071872)2.69477307
137keratan sulfate catabolic process (GO:0042340)2.69446036
138negative regulation of complement activation (GO:0045916)2.67835748
139negative regulation of fatty acid transport (GO:2000192)2.66827655
140myofibril assembly (GO:0030239)2.65445894
141peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.65432959
142patterning of blood vessels (GO:0001569)2.63827751
143plasma membrane repair (GO:0001778)2.63479204
144regulation of tight junction assembly (GO:2000810)2.62131989
145cell proliferation involved in kidney development (GO:0072111)2.61992910
146regulation of bile acid biosynthetic process (GO:0070857)2.61762852
147endocardial cushion development (GO:0003197)2.61728530
148positive regulation of steroid biosynthetic process (GO:0010893)2.61543186
149negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.61195834
150regulation of endothelial cell differentiation (GO:0045601)2.58576001
151regulation of extracellular matrix organization (GO:1903053)2.58069703
152positive regulation of natural killer cell differentiation (GO:0032825)2.57465795
153COPII vesicle coating (GO:0048208)2.57460542
154polyol transport (GO:0015791)2.55428423
155mRNA transcription (GO:0009299)2.53615243
156positive regulation of glycogen biosynthetic process (GO:0045725)2.53014143
157positive regulation of blood vessel endothelial cell migration (GO:0043536)2.51950977
158muscle filament sliding (GO:0030049)2.51250396
159actin-myosin filament sliding (GO:0033275)2.51250396
160extracellular matrix organization (GO:0030198)2.50610828
161negative regulation of protein autophosphorylation (GO:0031953)2.50538451
162protein localization to cell surface (GO:0034394)2.50296129
163metanephric mesenchyme development (GO:0072075)2.50154782
164extracellular structure organization (GO:0043062)2.49436608
165embryonic process involved in female pregnancy (GO:0060136)2.48724799
166negative regulation of Rho protein signal transduction (GO:0035024)2.47934425
167mesodermal cell differentiation (GO:0048333)2.47884029
168endothelial cell chemotaxis (GO:0035767)2.47816394
169negative regulation of stress fiber assembly (GO:0051497)2.47675207
170pinocytosis (GO:0006907)2.47327790
171kidney mesenchyme development (GO:0072074)2.46884101
172atrioventricular valve morphogenesis (GO:0003181)2.46882102
173acute-phase response (GO:0006953)2.46623132
174protein activation cascade (GO:0072376)2.46139073
175substrate-dependent cell migration (GO:0006929)2.45712832
176negative regulation of lipase activity (GO:0060192)2.45190925
177regulation of non-canonical Wnt signaling pathway (GO:2000050)2.44842894
178actin-mediated cell contraction (GO:0070252)2.44352636
179negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.44255684
180positive regulation of glycolytic process (GO:0045821)2.44007909
181response to epinephrine (GO:0071871)2.43635322
182white fat cell differentiation (GO:0050872)2.43202378
183cell-matrix adhesion (GO:0007160)2.43018881
184negative regulation of smooth muscle cell migration (GO:0014912)2.41478581
185cholesterol homeostasis (GO:0042632)2.40058932
186triglyceride homeostasis (GO:0070328)2.38228426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81738728
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.74137407
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.17713848
4CLOCK_20551151_ChIP-Seq_293T_Human3.90465572
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.63171703
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.96006647
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.95794101
8* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.89112508
9* RXR_22158963_ChIP-Seq_LIVER_Mouse2.84070975
10FOXA2_19822575_ChIP-Seq_HepG2_Human2.80314186
11* EP300_21415370_ChIP-Seq_HL-1_Mouse2.72375494
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69329965
13* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.63922009
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.61317779
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61163265
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.51993210
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.51038342
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.50111584
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.40158263
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.36938256
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33003976
22* CJUN_26792858_Chip-Seq_BT549_Human2.31940537
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.29516645
24HIF1A_21447827_ChIP-Seq_MCF-7_Human2.29500996
25ESR1_20079471_ChIP-ChIP_T-47D_Human2.28035358
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16101207
27ESR1_21235772_ChIP-Seq_MCF-7_Human2.14984900
28WT1_19549856_ChIP-ChIP_CCG9911_Human2.11681856
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.04083354
30PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00150665
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93599042
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.93419373
33* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91078252
34BRD4_25478319_ChIP-Seq_HGPS_Human1.85159716
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.85025471
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83313443
37TBX20_22080862_ChIP-Seq_HEART_Mouse1.82575740
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.82575740
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71888717
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71376606
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.69127707
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67400965
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58600889
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56705507
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56705507
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56351408
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56175307
48* HNF4A_19822575_ChIP-Seq_HepG2_Human1.55427277
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54781147
50GATA1_22025678_ChIP-Seq_K562_Human1.54499765
51* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51368111
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.43874454
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40666389
54AR_21572438_ChIP-Seq_LNCaP_Human1.39812313
55* FOXO3_23340844_ChIP-Seq_DLD1_Human1.39344038
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.38641938
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38173481
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38173481
59* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.37431449
60* SOX2_20726797_ChIP-Seq_SW620_Human1.32619904
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.30227208
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29833488
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27321846
64GATA4_25053715_ChIP-Seq_YYC3_Human1.27267256
65* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27089996
66MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.26771213
67* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25940580
68ZNF263_19887448_ChIP-Seq_K562_Human1.25572346
69* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.21663764
70* ISL1_27105846_Chip-Seq_CPCs_Mouse1.21638464
71* TCF4_18268006_ChIP-ChIP_LS174T_Human1.20388799
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19748931
73TP53_16413492_ChIP-PET_HCT116_Human1.18302268
74* UBF1/2_26484160_Chip-Seq_HMECs_Human1.18206255
75JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13372080
76* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11497668
77* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10906931
78* LXR_22158963_ChIP-Seq_LIVER_Mouse1.10468636
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10324961
80RXR_22108803_ChIP-Seq_LS180_Human1.09854475
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08627702
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08485946
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08016586
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06101631
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05808121
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04208615
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03412110
88FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03022147
89* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02934281
90* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02919529
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.01663102
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00803899
93TP53_18474530_ChIP-ChIP_U2OS_Human0.99303078
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97943037
95AHR_22903824_ChIP-Seq_MCF-7_Human0.97271627
96EED_16625203_ChIP-ChIP_MESCs_Mouse0.97046338
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95458420
98* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.95392924
99BCAT_22108803_ChIP-Seq_LS180_Human0.94829278
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94318771
101SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94214423
102CDX2_20551321_ChIP-Seq_CACO-2_Human0.94172018
103ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93555750
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92549578
105* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92464509
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92311054
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.91596975
108GATA1_19941826_ChIP-Seq_K562_Human0.89429029
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89251142
110* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87669377
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87029218
112* TP63_23658742_ChIP-Seq_EP156T_Human0.85600742
113* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84959813
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84767093
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84682533
116* RUNX_20019798_ChIP-Seq_JUKART_Human0.84533104
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84286066
118* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84157970
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83882276
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83299424
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82825787
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82777367
123* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82721209
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82451897
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.82315423
126* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82250684
127* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82250684
128RACK7_27058665_Chip-Seq_MCF-7_Human0.81749740
129GBX2_23144817_ChIP-Seq_PC3_Human0.79299743
130* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75630664
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75570676
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75508956
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75115154
134* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.74956588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.07635381
2MP0005275_abnormal_skin_tensile4.67833946
3MP0005503_abnormal_tendon_morphology4.05802748
4MP0004272_abnormal_basement_membrane3.98395501
5MP0003705_abnormal_hypodermis_morpholog3.59913938
6MP0006054_spinal_hemorrhage3.36782715
7MP0003279_aneurysm3.31338087
8MP0010368_abnormal_lymphatic_system3.09711887
9MP0001879_abnormal_lymphatic_vessel2.68696525
10MP0001958_emphysema2.53435147
11MP0010329_abnormal_lipoprotein_level2.47001967
12MP0003878_abnormal_ear_physiology2.30453155
13MP0005377_hearing/vestibular/ear_phenot2.30453155
14MP0005670_abnormal_white_adipose2.26960192
15MP0003195_calcinosis2.01046704
16MP0005365_abnormal_bile_salt1.94146187
17MP0004084_abnormal_cardiac_muscle1.93163424
18MP0003828_pulmonary_edema1.86693669
19MP0000639_abnormal_adrenal_gland1.83731682
20MP0005623_abnormal_meninges_morphology1.83040122
21MP0002060_abnormal_skin_morphology1.81171981
22MP0000751_myopathy1.76538017
23MP0000013_abnormal_adipose_tissue1.76529381
24MP0003566_abnormal_cell_adhesion1.75692539
25MP0000767_abnormal_smooth_muscle1.70521928
26MP0003045_fibrosis1.69751310
27MP0003950_abnormal_plasma_membrane1.66256696
28MP0006138_congestive_heart_failure1.65126986
29MP0002108_abnormal_muscle_morphology1.62994376
30MP0005508_abnormal_skeleton_morphology1.62344790
31MP0003724_increased_susceptibility_to1.59539761
32MP0009384_cardiac_valve_regurgitation1.59408872
33MP0005023_abnormal_wound_healing1.54230831
34MP0005360_urolithiasis1.48663262
35MP0002971_abnormal_brown_adipose1.47061525
36MP0002909_abnormal_adrenal_gland1.43860653
37MP0004130_abnormal_muscle_cell1.41534415
38MP0005666_abnormal_adipose_tissue1.38133187
39MP0000749_muscle_degeneration1.34391172
40MP0002837_dystrophic_cardiac_calcinosis1.30979883
41MP0000003_abnormal_adipose_tissue1.30156206
42MP0001666_abnormal_nutrient_absorption1.29697163
43MP0000750_abnormal_muscle_regeneration1.28073840
44MP0003868_abnormal_feces_composition1.27053150
45MP0005375_adipose_tissue_phenotype1.26299941
46MP0008775_abnormal_heart_ventricle1.25772401
47MP0005330_cardiomyopathy1.24774150
48MP0004036_abnormal_muscle_relaxation1.24343176
49MP0002295_abnormal_pulmonary_circulatio1.23268603
50MP0005408_hypopigmentation1.23047209
51MP0000343_altered_response_to1.19475723
52* MP0005385_cardiovascular_system_phenoty1.18717684
53* MP0001544_abnormal_cardiovascular_syste1.18717684
54MP0009840_abnormal_foam_cell1.17610350
55* MP0010630_abnormal_cardiac_muscle1.17122253
56MP0004185_abnormal_adipocyte_glucose1.16246378
57MP0002132_abnormal_respiratory_system1.14913829
58MP0002877_abnormal_melanocyte_morpholog1.14581123
59MP0002128_abnormal_blood_circulation1.14173533
60MP0003385_abnormal_body_wall1.13775509
61* MP0004087_abnormal_muscle_fiber1.12273180
62MP0002118_abnormal_lipid_homeostasis1.11857438
63MP0003091_abnormal_cell_migration1.10989909
64MP0000733_abnormal_muscle_development1.10789490
65MP0003300_gastrointestinal_ulcer1.09178554
66MP0004147_increased_porphyrin_level1.08325149
67MP0004215_abnormal_myocardial_fiber1.06043694
68MP0010352_gastrointestinal_tract_polyps1.05390742
69MP0002876_abnormal_thyroid_physiology1.03516201
70MP0008875_abnormal_xenobiotic_pharmacok1.03463730
71MP0002139_abnormal_hepatobiliary_system1.03071392
72MP0005620_abnormal_muscle_contractility0.98166621
73MP0002168_other_aberrant_phenotype0.97504715
74MP0003191_abnormal_cellular_cholesterol0.96736312
75MP0005058_abnormal_lysosome_morphology0.96566122
76MP0002972_abnormal_cardiac_muscle0.96427886
77MP0009780_abnormal_chondrocyte_physiolo0.96395521
78MP0002166_altered_tumor_susceptibility0.96173883
79* MP0001614_abnormal_blood_vessel0.95825679
80MP0002896_abnormal_bone_mineralization0.95262693
81MP0009250_abnormal_appendicular_skeleto0.94435158
82MP0005076_abnormal_cell_differentiation0.94105269
83MP0002089_abnormal_postnatal_growth/wei0.93370549
84* MP0002925_abnormal_cardiovascular_devel0.93088152
85MP0005451_abnormal_body_composition0.92943413
86MP0000609_abnormal_liver_physiology0.92408262
87MP0001243_abnormal_dermal_layer0.91788144
88MP0003252_abnormal_bile_duct0.91758208
89MP0004484_altered_response_of0.91685641
90MP0003959_abnormal_lean_body0.89882951
91MP0005083_abnormal_biliary_tract0.89245746
92MP0008004_abnormal_stomach_pH0.89045327
93MP0000534_abnormal_ureter_morphology0.88710063
94MP0003115_abnormal_respiratory_system0.88626092
95MP0005164_abnormal_response_to0.88549976
96MP0005085_abnormal_gallbladder_physiolo0.88447405
97MP0001915_intracranial_hemorrhage0.88128629
98MP0003942_abnormal_urinary_system0.87458790
99MP0005595_abnormal_vascular_smooth0.87406838
100MP0000759_abnormal_skeletal_muscle0.85521965
101MP0001756_abnormal_urination0.85334844
102MP0005390_skeleton_phenotype0.84697244
103MP0009115_abnormal_fat_cell0.84211384
104MP0004883_abnormal_blood_vessel0.84082799
105MP0001661_extended_life_span0.84055349
106* MP0000266_abnormal_heart_morphology0.83221242
107* MP0005369_muscle_phenotype0.82542377
108MP0005379_endocrine/exocrine_gland_phen0.80890940
109MP0002933_joint_inflammation0.80476566
110MP0003122_maternal_imprinting0.80391923
111MP0009278_abnormal_bone_marrow0.80227765
112MP0005171_absent_coat_pigmentation0.79994506
113MP0005388_respiratory_system_phenotype0.77640203
114MP0002133_abnormal_respiratory_system0.77640203
115MP0003690_abnormal_glial_cell0.77366639
116MP0005409_darkened_coat_color0.76486403
117MP0004808_abnormal_hematopoietic_stem0.76301060
118MP0002009_preneoplasia0.75914896
119MP0001542_abnormal_bone_strength0.74307905
120MP0005334_abnormal_fat_pad0.73839471
121MP0000249_abnormal_blood_vessel0.73513681
122MP0000163_abnormal_cartilage_morphology0.72992901
123MP0001175_abnormal_lung_morphology0.72303252
124MP0005167_abnormal_blood-brain_barrier0.71960005
125MP0001851_eye_inflammation0.71368667
126* MP0002115_abnormal_skeleton_extremities0.69421796
127* MP0002106_abnormal_muscle_physiology0.68853167
128MP0005257_abnormal_intraocular_pressure0.68572152
129MP0003011_delayed_dark_adaptation0.68256581
130MP0002254_reproductive_system_inflammat0.67336018
131MP0003941_abnormal_skin_development0.66640796
132MP0000566_synostosis0.66530236
133MP0005332_abnormal_amino_acid0.65601753
134MP0003123_paternal_imprinting0.65519491
135* MP0003567_abnormal_fetal_cardiomyocyte0.65431919
136MP0002970_abnormal_white_adipose0.64071047
137MP0005448_abnormal_energy_balance0.63912351
138MP0002269_muscular_atrophy0.63761088
139MP0002998_abnormal_bone_remodeling0.63274023
140MP0002932_abnormal_joint_morphology0.62465669
141MP0005165_increased_susceptibility_to0.62284764
142MP0001348_abnormal_lacrimal_gland0.60849931
143MP0000230_abnormal_systemic_arterial0.59673459

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.78086213
2Premature rupture of membranes (HP:0001788)6.00789159
3Deep venous thrombosis (HP:0002625)5.69512055
4Ankle contracture (HP:0006466)5.34899829
5Broad metatarsal (HP:0001783)5.32350018
6Aortic dissection (HP:0002647)5.13633056
7Aortic aneurysm (HP:0004942)4.72052350
8Complement deficiency (HP:0004431)4.69690927
9Cerebral aneurysm (HP:0004944)4.49523737
10Increased connective tissue (HP:0009025)4.34745715
11Type 1 muscle fiber predominance (HP:0003803)4.23046099
12Glomerulonephritis (HP:0000099)4.15775379
13Follicular hyperkeratosis (HP:0007502)4.06098055
14Soft skin (HP:0000977)3.99265726
15Atrophic scars (HP:0001075)3.91915033
16Prolonged partial thromboplastin time (HP:0003645)3.81038116
17Shallow orbits (HP:0000586)3.78834976
18Abnormality of the common coagulation pathway (HP:0010990)3.76119616
19Spinal rigidity (HP:0003306)3.72869405
20Abnormality of complement system (HP:0005339)3.65002552
21Fragile skin (HP:0001030)3.57906979
22Abnormality of carpal bone ossification (HP:0006257)3.39808939
23Small epiphyses (HP:0010585)3.37330646
24Joint hemorrhage (HP:0005261)3.27881040
25Bladder diverticulum (HP:0000015)3.25862523
26Mitral stenosis (HP:0001718)3.25607513
27Cervical subluxation (HP:0003308)3.24771409
28Mitral valve prolapse (HP:0001634)3.22768452
29Dilatation of the ascending aorta (HP:0005111)3.21799182
30Xanthomatosis (HP:0000991)3.09049529
31Wrist flexion contracture (HP:0001239)3.04775907
32Slender build (HP:0001533)2.94420126
33Aneurysm (HP:0002617)2.86831306
34Increased variability in muscle fiber diameter (HP:0003557)2.84655103
35Blue sclerae (HP:0000592)2.77947277
36Mildly elevated creatine phosphokinase (HP:0008180)2.76558588
37Abnormal hand bone ossification (HP:0010660)2.75006777
38Nephritis (HP:0000123)2.73537456
39Peritonitis (HP:0002586)2.72481979
40Skin nodule (HP:0200036)2.71908873
41Abnormal ossification of hand bones (HP:0005921)2.71693167
42Abnormality of skeletal muscle fiber size (HP:0012084)2.71145026
43Abnormal tarsal ossification (HP:0008369)2.70521891
44Vascular tortuosity (HP:0004948)2.69424847
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.69096993
46Osteolytic defects of the hand bones (HP:0009699)2.69096993
47Nonimmune hydrops fetalis (HP:0001790)2.68406518
48Lipoatrophy (HP:0100578)2.67461273
49Hypobetalipoproteinemia (HP:0003563)2.64617998
50Cardiovascular calcification (HP:0011915)2.64547917
51Epidermoid cyst (HP:0200040)2.63414181
52Wormian bones (HP:0002645)2.61414188
53Hemorrhage of the eye (HP:0011885)2.57200807
54Right ventricular cardiomyopathy (HP:0011663)2.55554921
55Arterial tortuosity (HP:0005116)2.55193568
56Hypercholesterolemia (HP:0003124)2.54585028
57Overgrowth (HP:0001548)2.54124879
58Broad palm (HP:0001169)2.53901552
59Flared iliac wings (HP:0002869)2.49914070
60Muscle fiber splitting (HP:0003555)2.46319569
61Cupped ribs (HP:0000887)2.44830732
62Syringomyelia (HP:0003396)2.40099750
63Spinal cord lesions (HP:0100561)2.40099750
64Lymphangioma (HP:0100764)2.39678275
65Systemic lupus erythematosus (HP:0002725)2.38572338
66Alacrima (HP:0000522)2.34069539
67Ovoid vertebral bodies (HP:0003300)2.33045248
68Flat acetabular roof (HP:0003180)2.31961319
69Vascular calcification (HP:0004934)2.30817233
70Joint laxity (HP:0001388)2.30735053
71Hypolipoproteinemia (HP:0010981)2.28938687
72Asymmetry of the thorax (HP:0001555)2.28871176
73Abnormality of dentin (HP:0010299)2.26682994
74Spondylolisthesis (HP:0003302)2.26664657
75Hyporeflexia of lower limbs (HP:0002600)2.26021263
76Acanthosis nigricans (HP:0000956)2.23485848
77Epiphyseal dysplasia (HP:0002656)2.23375401
78Hematochezia (HP:0002573)2.22775295
79Striae distensae (HP:0001065)2.22414178
80Alopecia of scalp (HP:0002293)2.21708862
81Menorrhagia (HP:0000132)2.21556560
82Vertebral compression fractures (HP:0002953)2.20915642
83Hyperextensible skin (HP:0000974)2.20843435
84Venous abnormality (HP:0002624)2.20714977
85Camptodactyly of toe (HP:0001836)2.20588071
86Limited elbow extension (HP:0001377)2.20472705
87Myocardial infarction (HP:0001658)2.20338273
88Abnormality of the wing of the ilium (HP:0011867)2.19679032
89Abnormality of the nasal septum (HP:0000419)2.19504255
90Abnormal foot bone ossification (HP:0010675)2.16672218
91Aplasia involving bones of the extremities (HP:0009825)2.15698360
92Aplasia involving bones of the upper limbs (HP:0009823)2.15698360
93Aplasia of the phalanges of the hand (HP:0009802)2.15698360
94Short hallux (HP:0010109)2.15349048
95Wide anterior fontanel (HP:0000260)2.15332432
96Abnormal delivery (HP:0001787)2.13987593
97Pigmentary retinal degeneration (HP:0001146)2.13514901
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12881430
99Short 4th metacarpal (HP:0010044)2.12881430
100Abnormality of the radial head (HP:0003995)2.12344012
101Coxa vara (HP:0002812)2.11639102
102Generalized amyotrophy (HP:0003700)2.11624627
103Neonatal short-limb short stature (HP:0008921)2.11318245
104Biconcave vertebral bodies (HP:0004586)2.09949610
105Venous insufficiency (HP:0005293)2.09306199
106Mesangial abnormality (HP:0001966)2.06708896
107Genu recurvatum (HP:0002816)2.06568276
108Ventricular tachycardia (HP:0004756)2.05830071
109Hypoalphalipoproteinemia (HP:0003233)2.04655360
110Pancreatic islet-cell hyperplasia (HP:0004510)2.03925174
111Osteoarthritis (HP:0002758)2.03755686
112Dislocated radial head (HP:0003083)2.03496039
113Hypoplasia of the iris (HP:0007676)1.99359811
114Pulmonary artery stenosis (HP:0004415)1.99197882
115Decreased lacrimation (HP:0000633)1.99092069
116Thin bony cortex (HP:0002753)1.98363039
117Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98282773
118Bowel diverticulosis (HP:0005222)1.97739642
119Mesomelia (HP:0003027)1.96252088
120Rectal prolapse (HP:0002035)1.95819882
121Round ear (HP:0100830)1.95507917
122Elbow flexion contracture (HP:0002987)1.95177281
123Spontaneous abortion (HP:0005268)1.93930470
124Facial shape deformation (HP:0011334)1.93568230
125Potter facies (HP:0002009)1.93568230
126Delayed closure of the anterior fontanelle (HP:0001476)1.93463844
127Aplasia/Hypoplasia of the hallux (HP:0008362)1.92554256
128Acanthocytosis (HP:0001927)1.92066213
129Reduced subcutaneous adipose tissue (HP:0003758)1.91294175
130Hypoglycemic coma (HP:0001325)1.91056044
131Abnormality of the 4th metacarpal (HP:0010012)1.90084877
132Ectopia lentis (HP:0001083)1.89577268
133Enlarged penis (HP:0000040)1.89472694
134Arthropathy (HP:0003040)1.88296098
135Aortic regurgitation (HP:0001659)1.85907314
136Gingival bleeding (HP:0000225)1.85327654
137Esophageal varix (HP:0002040)1.84592545
138Atrial fibrillation (HP:0005110)1.84179221
139Subacute progressive viral hepatitis (HP:0006572)1.84133552
140Exercise-induced muscle cramps (HP:0003710)1.83035469
141Abnormality of the lacrimal duct (HP:0011481)1.81477661
142Abnormality of the acetabulum (HP:0003170)1.78300538
143Abnormality of the calf musculature (HP:0001430)1.77339675
144Persistence of primary teeth (HP:0006335)1.77097615
145Recurrent corneal erosions (HP:0000495)1.76638233
146Recurrent gram-negative bacterial infections (HP:0005420)1.76602276
147Abnormality of the nasolacrimal system (HP:0000614)1.76433417
148Limb-girdle muscle weakness (HP:0003325)1.76191832
149Broad alveolar ridges (HP:0000187)1.75261792
150Abnormality of the intrinsic pathway (HP:0010989)1.74514412
151Hypoglycemic seizures (HP:0002173)1.74352852
152Testicular neoplasm (HP:0010788)1.73789335
153Scapular winging (HP:0003691)1.73677762
154Flexion contracture of toe (HP:0005830)1.73623887
155Joint contractures involving the joints of the feet (HP:0100492)1.73623887
156Gingival overgrowth (HP:0000212)1.73477934
157Tarsal synostosis (HP:0008368)1.72387521
158Wide nose (HP:0000445)1.71020158
159Mitral regurgitation (HP:0001653)1.70891619
160Chondrocalcinosis (HP:0000934)1.70807395
161Ulnar bowing (HP:0003031)1.69929526
162Impaired pain sensation (HP:0007328)1.69735143
163Abnormality of pain sensation (HP:0010832)1.69735143
164Inguinal hernia (HP:0000023)1.69233663
165Knee flexion contracture (HP:0006380)1.68426390
166Bilateral sensorineural hearing impairment (HP:0008619)1.67123792
167Supraventricular arrhythmia (HP:0005115)1.65787446
168Nasolacrimal duct obstruction (HP:0000579)1.65616511
169Dilated cardiomyopathy (HP:0001644)1.64642835
170Bone cyst (HP:0012062)1.64638069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.01889805
2TTN3.08190752
3TGFBR23.07952229
4TRIB33.01568048
5KDR2.95732301
6LATS12.86304280
7PDGFRA2.66708180
8ICK2.52907773
9MYLK2.39131971
10SIK12.32198332
11WNK42.31819538
12PKN22.02233092
13ERN12.01392898
14DDR21.99755484
15CAMK1D1.97652233
16TGFBR11.89474635
17RIPK11.89151491
18TYRO31.85594400
19OBSCN1.78326302
20EPHB21.73406287
21TRPM71.71641137
22DMPK1.67559004
23EPHA31.67225984
24STK31.65272913
25FGFR41.54000430
26CDK121.53829085
27PIK3CA1.45733802
28EPHB11.43007149
29FER1.41613070
30JAK31.40112587
31FRK1.39386757
32NEK91.39323372
33FGFR31.35268990
34LATS21.34714808
35CAMK1G1.33791686
36STK391.32423769
37PTK2B1.29382827
38NUAK11.28877740
39MAP3K21.24951840
40PTK61.24908256
41BCKDK1.24163859
42MAP3K61.20196160
43STK381.19620772
44PDK21.16548892
45PDGFRB1.05282743
46MELK1.04153749
47PAK21.04136050
48STK241.02307749
49MAP2K31.02214268
50FGFR20.95777585
51BMX0.94738325
52SGK20.93799986
53JAK10.93285507
54EEF2K0.91430103
55INSRR0.91207468
56MAP3K30.90820916
57PDK40.86604757
58PDK30.86604757
59FGFR10.86593759
60NLK0.86088534
61STK38L0.84260096
62PDPK10.83401611
63LMTK20.83243812
64PAK40.82092794
65SGK2230.80215239
66SGK4940.80215239
67PTK20.79762864
68LRRK20.79513534
69PDK10.78631205
70MAPK110.75592782
71MTOR0.75570970
72PRKCH0.75238463
73TEC0.75216649
74CSK0.74580833
75MAP3K130.73887112
76ILK0.70975175
77TXK0.70950230
78ZAP700.67687219
79PRKD30.67187330
80FLT30.66950253
81ROCK10.66444070
82MARK20.65792291
83AKT30.65163638
84BRD40.64499587
85MAP3K10.63615511
86ZAK0.63131402
87PRKAA20.62401125
88PRKAA10.61541043
89PRKD20.58197999
90MAPKAPK30.57740031
91KIT0.57591691
92RET0.57394452
93ITK0.56826638
94KSR20.55791245
95PRKD10.55694783
96TAOK30.54231774
97MST1R0.52477017
98SGK10.52434849
99MET0.52427384
100CDK60.51128888
101GRK50.50037777
102MAP3K70.49091739
103STK100.48960347
104MAP2K10.47484819
105MAPK120.45800461
106CDC42BPA0.44823952
107RPS6KA40.44390321
108CAMKK20.44185160
109IGF1R0.43764807
110ERBB20.40669101
111CAMK40.40571921
112PRKG20.40161021
113MAPK30.39599957
114GSK3A0.39368978
115MAP2K60.38979698
116INSR0.38787618
117SGK30.37857523
118CDK90.37059673
119RPS6KB10.35266781
120LCK0.33914298
121SRC0.32670279
122RPS6KC10.32656943
123RPS6KL10.32656943
124RPS6KA60.32436458
125JAK20.32267119
126PAK30.32217785
127NTRK10.31435043
128CDK80.31326380
129MAPK70.28230617
130ADRBK10.27187564
131PIK3CG0.26995477
132CHUK0.26939727
133YES10.26541516
134MAPK10.26405183
135MAPKAPK20.25052369
136WNK10.24976322
137TYK20.24442016

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.29321085
2Focal adhesion_Homo sapiens_hsa045103.05249212
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.50239677
4Dilated cardiomyopathy_Homo sapiens_hsa054142.41225037
5Protein digestion and absorption_Homo sapiens_hsa049742.27800996
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.23476011
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.15668184
8Small cell lung cancer_Homo sapiens_hsa052222.14325890
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08181037
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.06153034
11Adherens junction_Homo sapiens_hsa045202.04774502
12Fat digestion and absorption_Homo sapiens_hsa049752.02913078
13Amoebiasis_Homo sapiens_hsa051461.98700554
14PPAR signaling pathway_Homo sapiens_hsa033201.96784302
15Proteoglycans in cancer_Homo sapiens_hsa052051.90950010
16Propanoate metabolism_Homo sapiens_hsa006401.88622606
17Malaria_Homo sapiens_hsa051441.81844185
18Vitamin digestion and absorption_Homo sapiens_hsa049771.77955541
19ABC transporters_Homo sapiens_hsa020101.76922784
20Viral myocarditis_Homo sapiens_hsa054161.66030678
21TGF-beta signaling pathway_Homo sapiens_hsa043501.64813347
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.64510470
23Steroid biosynthesis_Homo sapiens_hsa001001.64217814
24Circadian rhythm_Homo sapiens_hsa047101.61198074
25Histidine metabolism_Homo sapiens_hsa003401.58992987
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.55355375
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51187897
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41763871
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.41591528
30Phenylalanine metabolism_Homo sapiens_hsa003601.39571589
31Platelet activation_Homo sapiens_hsa046111.35522684
32Toxoplasmosis_Homo sapiens_hsa051451.34311918
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.33613363
34Insulin resistance_Homo sapiens_hsa049311.33163151
35Fatty acid metabolism_Homo sapiens_hsa012121.30851452
36Fatty acid degradation_Homo sapiens_hsa000711.28827808
37Staphylococcus aureus infection_Homo sapiens_hsa051501.26868349
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23891108
39Nitrogen metabolism_Homo sapiens_hsa009101.22322834
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21771233
41Arginine biosynthesis_Homo sapiens_hsa002201.21343357
42Fatty acid biosynthesis_Homo sapiens_hsa000611.19841111
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.19057652
44Tyrosine metabolism_Homo sapiens_hsa003501.18614807
45Pathways in cancer_Homo sapiens_hsa052001.18119663
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16060203
47Hippo signaling pathway_Homo sapiens_hsa043901.15940798
48Bile secretion_Homo sapiens_hsa049761.15850053
49MicroRNAs in cancer_Homo sapiens_hsa052061.15644178
50HIF-1 signaling pathway_Homo sapiens_hsa040661.14844012
51Caffeine metabolism_Homo sapiens_hsa002321.11169439
52Other glycan degradation_Homo sapiens_hsa005111.10537491
53Rap1 signaling pathway_Homo sapiens_hsa040151.10229476
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08168150
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07265927
56Chronic myeloid leukemia_Homo sapiens_hsa052201.06588561
57Ovarian steroidogenesis_Homo sapiens_hsa049131.06419629
58Basal cell carcinoma_Homo sapiens_hsa052171.05244619
59Melanoma_Homo sapiens_hsa052181.02302625
60AMPK signaling pathway_Homo sapiens_hsa041521.00153322
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99038972
62Prostate cancer_Homo sapiens_hsa052150.95736171
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.94716266
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94174234
65Pancreatic cancer_Homo sapiens_hsa052120.93837410
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92748877
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.89104655
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85675702
69HTLV-I infection_Homo sapiens_hsa051660.85480708
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85432931
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83975197
72Lysine degradation_Homo sapiens_hsa003100.83109553
73Prion diseases_Homo sapiens_hsa050200.82984120
74Acute myeloid leukemia_Homo sapiens_hsa052210.81948974
75Complement and coagulation cascades_Homo sapiens_hsa046100.81452241
76TNF signaling pathway_Homo sapiens_hsa046680.81236339
77Tight junction_Homo sapiens_hsa045300.80484362
78Thyroid cancer_Homo sapiens_hsa052160.79772832
79Insulin signaling pathway_Homo sapiens_hsa049100.77141841
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75662906
81Bladder cancer_Homo sapiens_hsa052190.74615373
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74144491
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70747130
84Glucagon signaling pathway_Homo sapiens_hsa049220.70718707
85Notch signaling pathway_Homo sapiens_hsa043300.69480724
86Hedgehog signaling pathway_Homo sapiens_hsa043400.69143984
87Tryptophan metabolism_Homo sapiens_hsa003800.68438488
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66723751
89FoxO signaling pathway_Homo sapiens_hsa040680.66352740
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.66242762
91N-Glycan biosynthesis_Homo sapiens_hsa005100.65714154
92Pertussis_Homo sapiens_hsa051330.65385913
93Endometrial cancer_Homo sapiens_hsa052130.64201914
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63709412
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62292499
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.61243411
97Ras signaling pathway_Homo sapiens_hsa040140.60708965
98Choline metabolism in cancer_Homo sapiens_hsa052310.60627920
99Mineral absorption_Homo sapiens_hsa049780.60057435
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59383523
101Non-small cell lung cancer_Homo sapiens_hsa052230.57867820
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56235375
103Thyroid hormone synthesis_Homo sapiens_hsa049180.55138373
104Vitamin B6 metabolism_Homo sapiens_hsa007500.53538693
105Type II diabetes mellitus_Homo sapiens_hsa049300.53332697
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52942469
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.52059904
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51427929
109Renal cell carcinoma_Homo sapiens_hsa052110.51173408
110Glycerolipid metabolism_Homo sapiens_hsa005610.49997378
111Wnt signaling pathway_Homo sapiens_hsa043100.49412391
112Inositol phosphate metabolism_Homo sapiens_hsa005620.49243115
113Renin-angiotensin system_Homo sapiens_hsa046140.48633834
114Carbon metabolism_Homo sapiens_hsa012000.47694086
115Glioma_Homo sapiens_hsa052140.45669866
116Hepatitis B_Homo sapiens_hsa051610.45564311
117Melanogenesis_Homo sapiens_hsa049160.45419791
118Prolactin signaling pathway_Homo sapiens_hsa049170.44942810
119T cell receptor signaling pathway_Homo sapiens_hsa046600.44174797
120Dorso-ventral axis formation_Homo sapiens_hsa043200.43644558
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.42861242
122GnRH signaling pathway_Homo sapiens_hsa049120.42031058
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40785122
124Colorectal cancer_Homo sapiens_hsa052100.40691617
125Galactose metabolism_Homo sapiens_hsa000520.40130920
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40049342
127Chemical carcinogenesis_Homo sapiens_hsa052040.39790717
128Hematopoietic cell lineage_Homo sapiens_hsa046400.39101746
129Retinol metabolism_Homo sapiens_hsa008300.39049083
130mTOR signaling pathway_Homo sapiens_hsa041500.38188416
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38122733
132Osteoclast differentiation_Homo sapiens_hsa043800.38094078
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.37967915
134Pyruvate metabolism_Homo sapiens_hsa006200.37803598
135Renin secretion_Homo sapiens_hsa049240.37389545
136Starch and sucrose metabolism_Homo sapiens_hsa005000.37382591
137Estrogen signaling pathway_Homo sapiens_hsa049150.37222283
138Apoptosis_Homo sapiens_hsa042100.36251522
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36246553

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