TGFBR3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.43033976
2glutamate secretion (GO:0014047)5.71898696
3dicarboxylic acid biosynthetic process (GO:0043650)5.65747318
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.27532217
5L-phenylalanine catabolic process (GO:0006559)5.27532217
6synaptic vesicle exocytosis (GO:0016079)5.18922272
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.85778240
8L-phenylalanine metabolic process (GO:0006558)4.85778240
9synaptic vesicle maturation (GO:0016188)4.82634379
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.81715901
11aromatic amino acid family catabolic process (GO:0009074)4.73805216
12GDP-mannose metabolic process (GO:0019673)4.70231231
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.59910721
14protein retention in ER lumen (GO:0006621)4.50405543
15alpha-linolenic acid metabolic process (GO:0036109)4.48890355
16indole-containing compound catabolic process (GO:0042436)4.36262260
17indolalkylamine catabolic process (GO:0046218)4.36262260
18tryptophan catabolic process (GO:0006569)4.36262260
19regulation of cholesterol homeostasis (GO:2000188)4.33284430
20kynurenine metabolic process (GO:0070189)4.22937589
21high-density lipoprotein particle remodeling (GO:0034375)4.21649999
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.21116481
23tryptophan metabolic process (GO:0006568)4.16971803
24glutamate metabolic process (GO:0006536)3.98265091
25glyoxylate metabolic process (GO:0046487)3.96887302
26reverse cholesterol transport (GO:0043691)3.96034210
27negative regulation of cholesterol transport (GO:0032375)3.95344066
28negative regulation of sterol transport (GO:0032372)3.95344066
29positive regulation of synapse maturation (GO:0090129)3.93057680
30proline biosynthetic process (GO:0006561)3.91251028
31protein maturation by protein folding (GO:0022417)3.86550898
32regulation of cholesterol esterification (GO:0010872)3.84900982
33heparin metabolic process (GO:0030202)3.81260717
34heparin biosynthetic process (GO:0030210)3.81260717
35bile acid biosynthetic process (GO:0006699)3.79470375
36regulation of fibrinolysis (GO:0051917)3.78206845
37mitotic nuclear envelope reassembly (GO:0007084)3.73342789
38nuclear envelope reassembly (GO:0031468)3.73342789
39negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.68808648
40urea cycle (GO:0000050)3.67971475
41urea metabolic process (GO:0019627)3.67971475
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.66830325
43regulation of bile acid biosynthetic process (GO:0070857)3.66800507
44embryonic skeletal joint morphogenesis (GO:0060272)3.65804450
45plasma lipoprotein particle remodeling (GO:0034369)3.65612001
46protein-lipid complex remodeling (GO:0034368)3.65612001
47macromolecular complex remodeling (GO:0034367)3.65612001
48negative regulation of fibrinolysis (GO:0051918)3.59805863
49phospholipid efflux (GO:0033700)3.59115656
50response to gravity (GO:0009629)3.58418438
51regulation of mammary gland epithelial cell proliferation (GO:0033599)3.57354154
52positive regulation of triglyceride biosynthetic process (GO:0010867)3.54961312
53sulfur amino acid catabolic process (GO:0000098)3.53337623
54cellular modified amino acid catabolic process (GO:0042219)3.52487907
55nucleobase-containing small molecule interconversion (GO:0015949)3.50163822
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.46890703
57protein carboxylation (GO:0018214)3.44693071
58peptidyl-glutamic acid carboxylation (GO:0017187)3.44693071
59alpha-amino acid catabolic process (GO:1901606)3.43307031
60acylglycerol homeostasis (GO:0055090)3.41835707
61triglyceride homeostasis (GO:0070328)3.41835707
62plasma lipoprotein particle assembly (GO:0034377)3.41640354
63regulation of synaptic vesicle exocytosis (GO:2000300)3.40318855
64COPI coating of Golgi vesicle (GO:0048205)3.39721574
65Golgi transport vesicle coating (GO:0048200)3.39721574
66low-density lipoprotein particle remodeling (GO:0034374)3.38309906
67cellular biogenic amine catabolic process (GO:0042402)3.36252435
68amine catabolic process (GO:0009310)3.36252435
69cerebellar Purkinje cell layer development (GO:0021680)3.35926566
70bile acid metabolic process (GO:0008206)3.33492767
71tyrosine metabolic process (GO:0006570)3.33433777
72nucleoside diphosphate biosynthetic process (GO:0009133)3.28605762
73regulation of oxidative phosphorylation (GO:0002082)3.27930057
74cholesterol efflux (GO:0033344)3.26842496
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26712837
762-oxoglutarate metabolic process (GO:0006103)3.25586027
77regulation of triglyceride catabolic process (GO:0010896)3.25375166
78nitrogen cycle metabolic process (GO:0071941)3.23961835
79synaptic vesicle endocytosis (GO:0048488)3.23655839
80valine metabolic process (GO:0006573)3.22422562
81protein-lipid complex assembly (GO:0065005)3.21644243
82aromatic amino acid family metabolic process (GO:0009072)3.20415439
83sodium ion export (GO:0071436)3.20153068
84serine family amino acid catabolic process (GO:0009071)3.19827796
85regulation of fatty acid beta-oxidation (GO:0031998)3.16790886
86coenzyme catabolic process (GO:0009109)3.16746293
87regulation of triglyceride biosynthetic process (GO:0010866)3.15866866
88peptidyl-arginine omega-N-methylation (GO:0035247)3.15534616
89bile acid and bile salt transport (GO:0015721)3.14612852
90neurotransmitter secretion (GO:0007269)3.14165772
91cellular potassium ion homeostasis (GO:0030007)3.14129518
92positive regulation of fatty acid beta-oxidation (GO:0032000)3.11903417
93cellular amino acid catabolic process (GO:0009063)3.10984885
94type B pancreatic cell proliferation (GO:0044342)3.10626041
95phospholipid homeostasis (GO:0055091)3.09226627
96positive regulation of triglyceride metabolic process (GO:0090208)3.09053278
97regulation of protein activation cascade (GO:2000257)3.08945457
98plasma lipoprotein particle organization (GO:0071827)3.08741026
99positive regulation of histone deacetylation (GO:0031065)3.08492233
100regulation of synapse structural plasticity (GO:0051823)3.08021491
101retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.07963226
102indolalkylamine metabolic process (GO:0006586)3.06013662
103amino-acid betaine metabolic process (GO:0006577)3.04615875
104protein insertion into membrane (GO:0051205)3.04289815
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02189538
106positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.01549209
107cysteine metabolic process (GO:0006534)3.00596077
108complement activation, alternative pathway (GO:0006957)2.99918957
109protein-lipid complex subunit organization (GO:0071825)2.99252918
110cellular ketone body metabolic process (GO:0046950)2.98573106
111ethanol oxidation (GO:0006069)2.98256483
112glutamine family amino acid biosynthetic process (GO:0009084)2.97963334
113benzene-containing compound metabolic process (GO:0042537)2.97681559
114drug catabolic process (GO:0042737)2.96464197
115short-chain fatty acid metabolic process (GO:0046459)2.96448494
116regulation of synaptic vesicle transport (GO:1902803)2.94297255
117lysine metabolic process (GO:0006553)2.92147761
118lysine catabolic process (GO:0006554)2.92147761
119regulation of triglyceride metabolic process (GO:0090207)2.90259085
120acetyl-CoA metabolic process (GO:0006084)2.88350832
121histone H3-K4 trimethylation (GO:0080182)2.86701154
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86514999
123negative regulation of lipase activity (GO:0060192)2.86213888
124homocysteine metabolic process (GO:0050667)2.84479391
125plasma lipoprotein particle clearance (GO:0034381)2.83777865
126very-low-density lipoprotein particle assembly (GO:0034379)2.83320170
127regulation of voltage-gated calcium channel activity (GO:1901385)2.80714051
128protein import into peroxisome matrix (GO:0016558)2.79920785
129cellular glucuronidation (GO:0052695)2.77732909
130regulation of complement activation (GO:0030449)2.77647862
131locomotory exploration behavior (GO:0035641)2.77632870
132negative regulation of microtubule polymerization (GO:0031115)2.76883002
133regulation of cholesterol metabolic process (GO:0090181)2.76168294
134proline metabolic process (GO:0006560)2.75177465
135protein localization to endosome (GO:0036010)2.74692035
136layer formation in cerebral cortex (GO:0021819)2.74020446
137membrane tubulation (GO:0097320)2.71728907
138guanosine-containing compound biosynthetic process (GO:1901070)2.71690878
139gluconeogenesis (GO:0006094)2.71041601
140regulation of cellular respiration (GO:0043457)2.70823171
141cholesterol homeostasis (GO:0042632)2.70492740
142positive regulation of glycogen biosynthetic process (GO:0045725)2.70437580
143positive regulation of dendritic spine morphogenesis (GO:0061003)2.69760964
144adenosine receptor signaling pathway (GO:0001973)2.68982890
145lipoprotein metabolic process (GO:0042157)2.68769674
146regulation of neuronal synaptic plasticity (GO:0048168)2.68510307
147histone arginine methylation (GO:0034969)2.68169695
148fructose metabolic process (GO:0006000)2.67519409
149cytoskeletal anchoring at plasma membrane (GO:0007016)2.66272282
150positive regulation of neurotransmitter transport (GO:0051590)2.65707733
151positive regulation of neurotransmitter secretion (GO:0001956)2.65303562
152dicarboxylic acid transport (GO:0006835)2.65051918
153positive regulation of glycogen metabolic process (GO:0070875)2.64628527
154positive regulation of dendritic spine development (GO:0060999)2.64247939
155drug transmembrane transport (GO:0006855)2.63910458
156sterol homeostasis (GO:0055092)2.61958193
157intestinal cholesterol absorption (GO:0030299)2.61786807
158hexose biosynthetic process (GO:0019319)2.61328864
159regulation of synapse maturation (GO:0090128)2.58890593
160cofactor catabolic process (GO:0051187)2.55730556
161ADP metabolic process (GO:0046031)2.53827919
162regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.52431487
163negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.52366242
164purine nucleoside diphosphate metabolic process (GO:0009135)2.51379342
165purine ribonucleoside diphosphate metabolic process (GO:0009179)2.51379342
1662-deoxyribonucleotide biosynthetic process (GO:0009265)2.50563973
167deoxyribose phosphate biosynthetic process (GO:0046385)2.50563973
168protein targeting to plasma membrane (GO:0072661)2.49851739
169regulation of mitochondrial translation (GO:0070129)2.48170487
170amino acid import (GO:0043090)2.48024134
171regulation of synaptic plasticity (GO:0048167)2.47696096
172cellular zinc ion homeostasis (GO:0006882)2.47497356
173peptidyl-histidine modification (GO:0018202)2.46610174
174positive regulation of actin filament depolymerization (GO:0030836)2.46107324
175protein localization to synapse (GO:0035418)2.45874084
176positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41897700
177NADH metabolic process (GO:0006734)2.41056439
178AMP metabolic process (GO:0046033)2.39881267
179UTP biosynthetic process (GO:0006228)2.39493232
180regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.38862650
181positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.38862650
182regulation of protein sumoylation (GO:0033233)2.36565484
183monosaccharide biosynthetic process (GO:0046364)2.36163946
184pyrimidine nucleoside salvage (GO:0043097)2.35722846
185pyrimidine-containing compound salvage (GO:0008655)2.35722846
186peptidyl-arginine methylation (GO:0018216)2.35461485
187peptidyl-arginine N-methylation (GO:0035246)2.35461485
188barbed-end actin filament capping (GO:0051016)2.33572301
189GTP biosynthetic process (GO:0006183)2.33289535
190positive regulation of mitochondrion organization (GO:0010822)2.29687210
191exploration behavior (GO:0035640)2.27085200
192negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.26971252
193UV protection (GO:0009650)2.26696933
194regulation of release of cytochrome c from mitochondria (GO:0090199)2.26330079
195positive regulation of TOR signaling (GO:0032008)2.25849253
196regulation of long-term neuronal synaptic plasticity (GO:0048169)2.25830145
197cellular copper ion homeostasis (GO:0006878)2.24712647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.17647220
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.41797179
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.68976001
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.23468993
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.07762164
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.36923487
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.17456370
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.12805288
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.06133074
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.69937769
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60205369
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51938014
13ZNF263_19887448_ChIP-Seq_K562_Human2.39990968
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.35003246
15TET1_21451524_ChIP-Seq_MESCs_Mouse2.24613919
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17693870
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.13129416
18DROSHA_22980978_ChIP-Seq_HELA_Human2.12031844
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04683212
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03317283
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.00977869
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.95799232
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91063608
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88460181
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87047504
26XRN2_22483619_ChIP-Seq_HELA_Human1.82497270
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77799646
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77797708
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76904486
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.73271770
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.72094794
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71862260
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71644995
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70860210
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70775298
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.70401891
37SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.69622207
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68667012
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65018414
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63266632
41KDM2B_26808549_Chip-Seq_DND41_Human1.61298009
42LXR_22292898_ChIP-Seq_THP-1_Human1.59651078
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59159863
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56811905
45SCL_19346495_ChIP-Seq_HPC-7_Human1.56174555
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55508355
47RUNX_20019798_ChIP-Seq_JUKART_Human1.55391151
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54486551
49TCF7_22412390_ChIP-Seq_EML_Mouse1.51886975
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51344197
51SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51175753
52TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48991290
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45634029
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43864192
55FOXP1_21924763_ChIP-Seq_HESCs_Human1.42121457
56BCOR_27268052_Chip-Seq_Bcells_Human1.40409546
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40369094
58CLOCK_20551151_ChIP-Seq_293T_Human1.39482663
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38753199
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.38595498
61MYC_22102868_ChIP-Seq_BL_Human1.37415994
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.36182401
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35842969
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35736831
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34307804
66BCL6_27268052_Chip-Seq_Bcells_Human1.33802200
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32367541
68ATF3_27146783_Chip-Seq_COLON_Human1.30351825
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29306355
70KDM2B_26808549_Chip-Seq_K562_Human1.28458552
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.28361696
72DCP1A_22483619_ChIP-Seq_HELA_Human1.28241804
73CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27441451
74CTCF_20526341_ChIP-Seq_ESCs_Human1.26007005
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25904230
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25403091
77PHF8_20622854_ChIP-Seq_HELA_Human1.24243612
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24116090
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.23426641
80SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.23379571
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.23217503
82E2F1_20622854_ChIP-Seq_HELA_Human1.23084912
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22796766
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22404883
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.21958203
86GABP_19822575_ChIP-Seq_HepG2_Human1.20935316
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20750446
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20354638
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19067936
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18236386
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18130080
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18125626
93VDR_21846776_ChIP-Seq_THP-1_Human1.17514320
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.17218271
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16176275
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15743114
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.15513814
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15103077
99RARB_24833708_ChIP-Seq_LIVER_Mouse1.14981732
100MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14741734
101TP53_22127205_ChIP-Seq_IMR90_Human1.13801250
102CTCF_21964334_Chip-Seq_Bcells_Human1.12257274
103CREB1_26743006_Chip-Seq_LNCaP_Human1.11721343
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10946363
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.09965798
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09378180
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09192505
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08419719
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08378030
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08366006
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07219126
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06954968
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.06884294
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06670498
115CTCF_27219007_Chip-Seq_Bcells_Human1.06322870
116MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05209329
117CTCF_26484167_Chip-Seq_Bcells_Mouse1.04682512
118GATA1_19941826_ChIP-Seq_K562_Human1.04653944
119E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04446803
120TP63_17297297_ChIP-ChIP_HaCaT_Human1.02876486
121HNF4A_19822575_ChIP-Seq_HepG2_Human1.02277484
122MAF_26560356_Chip-Seq_TH2_Human1.02255709
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01525530
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01405379
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01183663
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01178760
127TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00892332
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00838058
129ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00768529
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98373133
131SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98228003
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97924643
133SMC4_20622854_ChIP-Seq_HELA_Human0.96210912
134GBX2_23144817_ChIP-Seq_PC3_Human0.94958392
135UTX_26944678_Chip-Seq_JUKART_Human0.94772310
136MYC_27129775_Chip-Seq_CORNEA_Mouse0.94642832
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.93942479
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.93942479
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93685920
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.93598670
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93112946
142FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91285302
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90492450
144ISL1_27105846_Chip-Seq_CPCs_Mouse0.90390912
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88839135
146AR_19668381_ChIP-Seq_PC3_Human0.88402286
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88275973
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87319130
149SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83863576
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83541873
151GATA1_22025678_ChIP-Seq_K562_Human0.83502956
152ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83251486
153RACK7_27058665_Chip-Seq_MCF-7_Human0.81568232
154SA1_27219007_Chip-Seq_ERYTHROID_Human0.81501347
155RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80900203
156SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80541204
157P68_20966046_ChIP-Seq_HELA_Human0.80129258
158TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80078825
159MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79980357
160REST_18959480_ChIP-ChIP_MESCs_Mouse0.79828000
161MAF_26560356_Chip-Seq_TH1_Human0.79721351
162VDR_24763502_ChIP-Seq_THP-1_Human0.79564116
163VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78422109
164ELK3_25401928_ChIP-Seq_HUVEC_Human0.77478418
165TP63_22573176_ChIP-Seq_HFKS_Human0.76836514
166WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76724982
167CTCF_21964334_ChIP-Seq_BJAB-B_Human0.75502917
168STAT6_21828071_ChIP-Seq_BEAS2B_Human0.74247978
169RING1B_27294783_Chip-Seq_ESCs_Mouse0.74242879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.28552118
2MP0005360_urolithiasis5.36886566
3MP0005365_abnormal_bile_salt5.01815541
4MP0005085_abnormal_gallbladder_physiolo4.74592287
5MP0008875_abnormal_xenobiotic_pharmacok3.87946842
6MP0010329_abnormal_lipoprotein_level3.39511386
7MP0003252_abnormal_bile_duct3.31764429
8MP0003868_abnormal_feces_composition3.10127777
9MP0003880_abnormal_central_pattern3.05557051
10MP0004270_analgesia3.04570666
11MP0005551_abnormal_eye_electrophysiolog2.97459877
12MP0005058_abnormal_lysosome_morphology2.77455291
13MP0001666_abnormal_nutrient_absorption2.71387538
14MP0005670_abnormal_white_adipose2.71099085
15MP0009840_abnormal_foam_cell2.66529002
16MP0003123_paternal_imprinting2.63156612
17MP0003635_abnormal_synaptic_transmissio2.58618747
18MP0002064_seizures2.46518431
19MP0005083_abnormal_biliary_tract2.22603024
20MP0000749_muscle_degeneration2.21701654
21MP0010030_abnormal_orbit_morphology2.16048720
22MP0003879_abnormal_hair_cell2.12213521
23MP0008961_abnormal_basal_metabolism2.09052851
24MP0003011_delayed_dark_adaptation2.03132997
25MP0009780_abnormal_chondrocyte_physiolo2.00015224
26MP0001968_abnormal_touch/_nociception1.98172984
27MP0000609_abnormal_liver_physiology1.97847512
28MP0002118_abnormal_lipid_homeostasis1.97634267
29MP0009745_abnormal_behavioral_response1.91884165
30MP0002877_abnormal_melanocyte_morpholog1.84763755
31MP0002063_abnormal_learning/memory/cond1.84178889
32MP0008260_abnormal_autophagy1.82285610
33MP0005623_abnormal_meninges_morphology1.77596291
34MP0001502_abnormal_circadian_rhythm1.77403192
35MP0005220_abnormal_exocrine_pancreas1.72691945
36MP0005332_abnormal_amino_acid1.72169430
37MP0004233_abnormal_muscle_weight1.71232080
38MP0000537_abnormal_urethra_morphology1.69297662
39MP0002249_abnormal_larynx_morphology1.68292347
40MP0002638_abnormal_pupillary_reflex1.66710374
41MP0006072_abnormal_retinal_apoptosis1.65269142
42MP0000750_abnormal_muscle_regeneration1.64025719
43MP0003191_abnormal_cellular_cholesterol1.61320072
44MP0009046_muscle_twitch1.58510256
45MP0005253_abnormal_eye_physiology1.55819468
46MP0004885_abnormal_endolymph1.55377078
47MP0000678_abnormal_parathyroid_gland1.54533552
48MP0002734_abnormal_mechanical_nocicepti1.51287290
49MP0005334_abnormal_fat_pad1.50919968
50MP0002572_abnormal_emotion/affect_behav1.50654434
51MP0002736_abnormal_nociception_after1.50254709
52MP0002272_abnormal_nervous_system1.50130352
53MP0003075_altered_response_to1.48578919
54MP0004147_increased_porphyrin_level1.48235512
55MP0001905_abnormal_dopamine_level1.47151730
56MP0001346_abnormal_lacrimal_gland1.43985309
57MP0002971_abnormal_brown_adipose1.30638674
58MP0005257_abnormal_intraocular_pressure1.29624228
59MP0002138_abnormal_hepatobiliary_system1.28825815
60MP0001873_stomach_inflammation1.28317089
61MP0005319_abnormal_enzyme/_coenzyme1.27492429
62MP0004130_abnormal_muscle_cell1.26328820
63MP0000003_abnormal_adipose_tissue1.22462251
64MP0002078_abnormal_glucose_homeostasis1.21540208
65MP0005195_abnormal_posterior_eye1.14684373
66MP0002735_abnormal_chemical_nociception1.14142566
67MP0001970_abnormal_pain_threshold1.13219345
68MP0006036_abnormal_mitochondrial_physio1.12923409
69MP0004510_myositis1.11748069
70MP0002234_abnormal_pharynx_morphology1.08735882
71MP0009384_cardiac_valve_regurgitation1.08602186
72MP0000681_abnormal_thyroid_gland1.08288620
73MP0005501_abnormal_skin_physiology1.08027567
74MP0004811_abnormal_neuron_physiology1.07924588
75MP0004858_abnormal_nervous_system1.07305101
76MP0000685_abnormal_immune_system1.06900078
77MP0003806_abnormal_nucleotide_metabolis1.06075905
78MP0000920_abnormal_myelination1.06049110
79MP0002066_abnormal_motor_capabilities/c1.05739306
80MP0003300_gastrointestinal_ulcer1.05480515
81MP0004019_abnormal_vitamin_homeostasis1.03725821
82MP0002733_abnormal_thermal_nociception1.03572365
83MP0005584_abnormal_enzyme/coenzyme_acti1.03498873
84MP0001188_hyperpigmentation1.01227719
85MP0000759_abnormal_skeletal_muscle1.00360858
86MP0002970_abnormal_white_adipose1.00175682
87MP0001849_ear_inflammation1.00113978
88MP0003705_abnormal_hypodermis_morpholog0.97193191
89MP0004185_abnormal_adipocyte_glucose0.96578521
90MP0003866_abnormal_defecation0.96361332
91MP0002090_abnormal_vision0.95404773
92MP0001324_abnormal_eye_pigmentation0.94868961
93MP0003634_abnormal_glial_cell0.93374933
94MP0003329_amyloid_beta_deposits0.92286593
95MP0005451_abnormal_body_composition0.91433188
96MP0004215_abnormal_myocardial_fiber0.91333373
97MP0000733_abnormal_muscle_development0.90385987
98MP0008775_abnormal_heart_ventricle0.89500975
99MP0005165_increased_susceptibility_to0.88818126
100MP0008438_abnormal_cutaneous_collagen0.88683873
101MP0000598_abnormal_liver_morphology0.87911036
102MP0004036_abnormal_muscle_relaxation0.87722046
103MP0005647_abnormal_sex_gland0.87708442
104MP0002229_neurodegeneration0.87588604
105MP0001486_abnormal_startle_reflex0.87548659
106MP0001764_abnormal_homeostasis0.87475101
107MP0000013_abnormal_adipose_tissue0.87199014
108MP0003315_abnormal_perineum_morphology0.86642372
109MP0005448_abnormal_energy_balance0.85774223
110MP0001661_extended_life_span0.85585523
111MP0002269_muscular_atrophy0.85380258
112MP0003953_abnormal_hormone_level0.85088302
113MP0009672_abnormal_birth_weight0.85058329
114MP0003279_aneurysm0.84554087
115MP0001984_abnormal_olfaction0.83890428
116MP0000604_amyloidosis0.82487890
117MP0005166_decreased_susceptibility_to0.81083775
118MP0001944_abnormal_pancreas_morphology0.79600257
119MP0002332_abnormal_exercise_endurance0.79567246
120MP0002089_abnormal_postnatal_growth/wei0.79472553
121MP0009642_abnormal_blood_homeostasis0.79364224
122MP0002882_abnormal_neuron_morphology0.77581733
123MP0008874_decreased_physiological_sensi0.77018467
124MP0003693_abnormal_embryo_hatching0.76672008
125MP0004859_abnormal_synaptic_plasticity0.76045066
126MP0004087_abnormal_muscle_fiber0.75964582
127MP0001986_abnormal_taste_sensitivity0.75897321
128MP0005330_cardiomyopathy0.74835798
129MP0005391_vision/eye_phenotype0.74780747
130MP0003631_nervous_system_phenotype0.74113734
131MP0005666_abnormal_adipose_tissue0.73826989
132MP0004084_abnormal_cardiac_muscle0.72537983
133MP0000762_abnormal_tongue_morphology0.72053511
134MP0005248_abnormal_Harderian_gland0.70845849
135MP0000747_muscle_weakness0.70362351
136MP0003633_abnormal_nervous_system0.69851682
137MP0005423_abnormal_somatic_nervous0.69491516
138MP0000534_abnormal_ureter_morphology0.68775024
139MP0001348_abnormal_lacrimal_gland0.68228903
140MP0002067_abnormal_sensory_capabilities0.68188467
141MP0010771_integument_phenotype0.67851204
142MP0009643_abnormal_urine_homeostasis0.66907072
143MP0000751_myopathy0.66791046
144MP0003453_abnormal_keratinocyte_physiol0.66502657
145MP0002909_abnormal_adrenal_gland0.65979102
146MP0002060_abnormal_skin_morphology0.65408215
147MP0008932_abnormal_embryonic_tissue0.64552795
148MP0000955_abnormal_spinal_cord0.64504540
149MP0005535_abnormal_body_temperature0.63637492
150MP0002557_abnormal_social/conspecific_i0.63583335
151MP0009115_abnormal_fat_cell0.63155760
152MP0005464_abnormal_platelet_physiology0.62970664
153MP0009697_abnormal_copulation0.62500320
154MP0002796_impaired_skin_barrier0.62412522
155MP0002127_abnormal_cardiovascular_syste0.62006150
156MP0005645_abnormal_hypothalamus_physiol0.61372140
157MP0005171_absent_coat_pigmentation0.61250580
158MP0010630_abnormal_cardiac_muscle0.60347209
159MP0002837_dystrophic_cardiac_calcinosis0.60036847
160MP0008569_lethality_at_weaning0.59765527
161MP0002069_abnormal_eating/drinking_beha0.59327112
162MP0003172_abnormal_lysosome_physiology0.59203836
163MP0002295_abnormal_pulmonary_circulatio0.58838237
164MP0003183_abnormal_peptide_metabolism0.58667092
165MP0001501_abnormal_sleep_pattern0.55557930
166MP0009763_increased_sensitivity_to0.55530666
167MP0005452_abnormal_adipose_tissue0.55490477
168MP0002928_abnormal_bile_duct0.55053996
169MP0005646_abnormal_pituitary_gland0.54771242
170MP0001853_heart_inflammation0.52934964
171MP0003115_abnormal_respiratory_system0.52510997
172MP0008872_abnormal_physiological_respon0.51461691
173MP0000639_abnormal_adrenal_gland0.50524003
174MP0008877_abnormal_DNA_methylation0.50405795
175MP0002822_catalepsy0.49747470

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.20621384
2Deep venous thrombosis (HP:0002625)5.15672160
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.80509049
4Hyperlipoproteinemia (HP:0010980)4.71960902
5Abnormality of macular pigmentation (HP:0008002)4.57585320
6Myokymia (HP:0002411)4.34241029
7Xanthomatosis (HP:0000991)4.32293995
8Intrahepatic cholestasis (HP:0001406)4.26684084
9Prolonged partial thromboplastin time (HP:0003645)4.18122256
10Central scotoma (HP:0000603)3.88435506
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.67497312
12Abnormality of methionine metabolism (HP:0010901)3.53076243
13Macroorchidism (HP:0000053)3.40209237
14Abnormality of sulfur amino acid metabolism (HP:0004339)3.39635837
15Ketosis (HP:0001946)3.39114945
16Pigmentary retinal degeneration (HP:0001146)3.30683088
17Hypoglycemic coma (HP:0001325)3.26855402
18Hypobetalipoproteinemia (HP:0003563)3.23469479
19Insomnia (HP:0100785)3.14361765
20Hypoalphalipoproteinemia (HP:0003233)3.11997095
21Testicular atrophy (HP:0000029)3.08775980
22Delusions (HP:0000746)3.05493615
23Visual hallucinations (HP:0002367)3.04165918
24Vertebral compression fractures (HP:0002953)3.03404427
25Supranuclear gaze palsy (HP:0000605)2.98735393
26Chorioretinal atrophy (HP:0000533)2.96055796
27Cerebral hypomyelination (HP:0006808)2.95767264
28Distal upper limb amyotrophy (HP:0007149)2.94157549
29Upper limb amyotrophy (HP:0009129)2.94157549
30Annular pancreas (HP:0001734)2.92805325
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91231160
32Abnormality of the common coagulation pathway (HP:0010990)2.91215075
33Myoglobinuria (HP:0002913)2.90847252
34Hypercholesterolemia (HP:0003124)2.88599696
35Joint hemorrhage (HP:0005261)2.88522257
36Large for gestational age (HP:0001520)2.86069295
37Ketoacidosis (HP:0001993)2.85286467
38Gingival bleeding (HP:0000225)2.83259117
39Hypolipoproteinemia (HP:0010981)2.83198789
40Achilles tendon contracture (HP:0001771)2.82283865
41Hyperammonemia (HP:0001987)2.80471645
42Scotoma (HP:0000575)2.75377859
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.73992367
44Hypoglycemic seizures (HP:0002173)2.72563426
45Difficulty climbing stairs (HP:0003551)2.66747897
46Abnormality of the pancreatic islet cells (HP:0006476)2.66371987
47Abnormality of endocrine pancreas physiology (HP:0012093)2.66371987
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.65199970
49Back pain (HP:0003418)2.62393849
50Abnormal rod and cone electroretinograms (HP:0008323)2.60934844
51Distal lower limb muscle weakness (HP:0009053)2.60327569
52Amblyopia (HP:0000646)2.59548723
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58321701
54Epidermoid cyst (HP:0200040)2.57473948
55Decreased central vision (HP:0007663)2.55845190
56Premature rupture of membranes (HP:0001788)2.54657083
57Truncal ataxia (HP:0002078)2.52052620
58Abnormality of the intrinsic pathway (HP:0010989)2.51663267
59Bony spicule pigmentary retinopathy (HP:0007737)2.49700195
60Hand muscle atrophy (HP:0009130)2.47543314
61Ankle clonus (HP:0011448)2.45763912
62Pseudobulbar signs (HP:0002200)2.44790813
63Ulnar bowing (HP:0003031)2.44657288
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44523094
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44523094
66Abnormality of the Achilles tendon (HP:0005109)2.44345739
67Hypokinesia (HP:0002375)2.42895585
68Pendular nystagmus (HP:0012043)2.42483627
69Focal motor seizures (HP:0011153)2.41338704
70Ragged-red muscle fibers (HP:0003200)2.40342128
71Neonatal onset (HP:0003623)2.40333194
72Hyperbilirubinemia (HP:0002904)2.39712636
73Myopathic facies (HP:0002058)2.38005505
74Stridor (HP:0010307)2.36386948
75Complement deficiency (HP:0004431)2.35469320
76Symptomatic seizures (HP:0011145)2.35047244
77Depression (HP:0000716)2.33256592
78Hyperinsulinemic hypoglycemia (HP:0000825)2.29785498
79Enlarged kidneys (HP:0000105)2.28607998
80Axonal loss (HP:0003447)2.28512724
81Epileptic encephalopathy (HP:0200134)2.27402423
82Severe visual impairment (HP:0001141)2.22721183
83Increased muscle lipid content (HP:0009058)2.22010811
84Sensorimotor neuropathy (HP:0007141)2.21596973
85Hypochromic microcytic anemia (HP:0004840)2.20270400
86Increased intramyocellular lipid droplets (HP:0012240)2.20073775
87Reduced subcutaneous adipose tissue (HP:0003758)2.19062221
88Abnormality of glycine metabolism (HP:0010895)2.18611391
89Abnormality of serine family amino acid metabolism (HP:0010894)2.18611391
90Unilateral renal agenesis (HP:0000122)2.18457176
91Abnormality of the fingertips (HP:0001211)2.16569197
92Spinal rigidity (HP:0003306)2.15782285
93Truncus arteriosus (HP:0001660)2.15463256
94Abnormality of fatty-acid metabolism (HP:0004359)2.14886328
95Hyperglycinuria (HP:0003108)2.14341228
96Enlarged penis (HP:0000040)2.12042850
97Distal lower limb amyotrophy (HP:0008944)2.07148779
98Acanthocytosis (HP:0001927)2.06010367
99Late onset (HP:0003584)2.05663233
100Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05647044
101Macular degeneration (HP:0000608)2.04035869
102Hyperglycinemia (HP:0002154)2.02443052
103Neurofibrillary tangles (HP:0002185)2.00931976
104Hydroureter (HP:0000072)2.00855807
105Akinesia (HP:0002304)2.00722400
106Rough bone trabeculation (HP:0100670)1.99835801
107Microretrognathia (HP:0000308)1.99798588
108Confusion (HP:0001289)1.99646424
109Poikilocytosis (HP:0004447)1.99032067
110Retinal dysplasia (HP:0007973)1.98938331
111Cerebral inclusion bodies (HP:0100314)1.98846117
112Biconcave vertebral bodies (HP:0004586)1.98173846
113Renal Fanconi syndrome (HP:0001994)1.98077500
114Status epilepticus (HP:0002133)1.97950804
115Poor eye contact (HP:0000817)1.97707993
116Diaphragmatic weakness (HP:0009113)1.97037031
117Neuronal loss in central nervous system (HP:0002529)1.96878233
118Emotional lability (HP:0000712)1.96702774
119Hypochromic anemia (HP:0001931)1.95829737
120Abolished electroretinogram (ERG) (HP:0000550)1.95461029
121Bulbar palsy (HP:0001283)1.94955118
122Fat malabsorption (HP:0002630)1.94348755
123Abnormal platelet volume (HP:0011876)1.93863572
124Overlapping toe (HP:0001845)1.93802182
125Progressive muscle weakness (HP:0003323)1.93736210
126Thin bony cortex (HP:0002753)1.92724072
127Abnormal mitochondria in muscle tissue (HP:0008316)1.91826714
128Hemiplegia (HP:0002301)1.90038017
129Generalized amyotrophy (HP:0003700)1.89265821
130Cholecystitis (HP:0001082)1.89216998
131Abnormal gallbladder physiology (HP:0012438)1.89216998
132Severe muscular hypotonia (HP:0006829)1.88932229
133Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88755504
134Dicarboxylic aciduria (HP:0003215)1.88755504
135Heterotopia (HP:0002282)1.88630780
136Abnormality of iron homeostasis (HP:0011031)1.87977969
137Delayed CNS myelination (HP:0002188)1.87861315
138Athetosis (HP:0002305)1.87639224
139Congenital malformation of the right heart (HP:0011723)1.87454222
140Double outlet right ventricle (HP:0001719)1.87454222
141Panhypogammaglobulinemia (HP:0003139)1.87345623
142Gastrointestinal inflammation (HP:0004386)1.87160069
143Reticulocytosis (HP:0001923)1.86131289
144Focal dystonia (HP:0004373)1.86031711
145Mitral stenosis (HP:0001718)1.85845707
146Dyschromatopsia (HP:0007641)1.85196623
147Pancreatic islet-cell hyperplasia (HP:0004510)1.84938594
148Focal seizures (HP:0007359)1.84821929
149Hemorrhage of the eye (HP:0011885)1.84773022
150Hepatocellular necrosis (HP:0001404)1.84721806
151Obsessive-compulsive behavior (HP:0000722)1.84156210
152Hyperacusis (HP:0010780)1.83480346
153Broad distal phalanx of finger (HP:0009836)1.83194923
154Centrally nucleated skeletal muscle fibers (HP:0003687)1.83128855
155Abnormal atrioventricular conduction (HP:0005150)1.81147885
156Craniofacial dystonia (HP:0012179)1.80916760
157Prolonged neonatal jaundice (HP:0006579)1.80060878
158Foot dorsiflexor weakness (HP:0009027)1.79798509
159Diminished movement (HP:0002374)1.78770012
160Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78563001
161Lower limb amyotrophy (HP:0007210)1.77496522
162Obstructive sleep apnea (HP:0002870)1.77189605
163Abnormal trabecular bone morphology (HP:0100671)1.77165954
164Supernumerary nipples (HP:0002558)1.77052564
165Gout (HP:0001997)1.76862662
166Abnormality of glycolysis (HP:0004366)1.76032176
167Torticollis (HP:0000473)1.75826461
168Abnormality of liposaccharide metabolism (HP:0010968)1.75619533
169Abnormality of glycosphingolipid metabolism (HP:0004343)1.75619533
170Abnormality of glycolipid metabolism (HP:0010969)1.75619533
171Abnormal delayed hypersensitivity skin test (HP:0002963)1.75600886
172Cholelithiasis (HP:0001081)1.74973805
173Elbow flexion contracture (HP:0002987)1.74496275
174Menorrhagia (HP:0000132)1.74226146
175Abnormal gallbladder morphology (HP:0012437)1.73641589
176Spinal cord compression (HP:0002176)1.72983978
177Congenital glaucoma (HP:0001087)1.71678375
178Abnormality of transition element cation homeostasis (HP:0011030)1.70821973
179Unsteady gait (HP:0002317)1.69665518
180Transposition of the great arteries (HP:0001669)1.69657536
181Abnormal connection of the cardiac segments (HP:0011545)1.69657536
182Abnormal ventriculo-arterial connection (HP:0011563)1.69657536
183Limb-girdle muscle atrophy (HP:0003797)1.68876207
184Hyperthyroidism (HP:0000836)1.68463234
185Myocardial infarction (HP:0001658)1.68389674
186Acute hepatic failure (HP:0006554)1.68210562
187Rapidly progressive (HP:0003678)1.68152964
188Exercise intolerance (HP:0003546)1.67477152
189Mitochondrial inheritance (HP:0001427)1.66192545
190Increased hepatocellular lipid droplets (HP:0006565)1.65139069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.05251399
2SIK14.01601056
3VRK23.33947703
4ARAF3.30839728
5TRIB33.26844770
6SIK23.22213125
7TESK12.99913766
8PRKD32.97187592
9SMG12.93030498
10PKN22.89020897
11ERN12.65554724
12FGFR42.64591188
13IRAK32.63180996
14MAP3K102.50740788
15EEF2K2.45657891
16EPHA22.35880096
17SIK32.33745887
18LIMK12.31117892
19CAMK1D2.30471886
20INSRR2.29588555
21MAP3K72.19933490
22TESK22.13169125
23CAMK1G2.07903619
24TNIK1.99149874
25MAP3K111.94746242
26MAP4K11.92995576
27GRK51.88028094
28FLT31.74433578
29BUB11.74389939
30DAPK11.74284260
31PTK61.70396980
32BCKDK1.69772294
33RIPK11.65718996
34NTRK21.64858234
35PIM21.59215517
36FGFR31.43541186
37MARK21.43416243
38STK381.38931349
39DAPK21.29474482
40BRD41.28501118
41BRAF1.27846133
42TYK21.27498885
43ABL21.26263055
44PRPF4B1.25652800
45CDK151.19552664
46BRSK11.18536164
47MST1R1.15837530
48FGFR21.15473309
49CDK181.15431553
50CDK11A1.15152384
51TNK21.13505984
52CDK141.09379693
53BTK1.08468410
54MAP3K91.07577021
55PRKAA21.07414289
56IRAK21.07277795
57ICK1.06588417
58EPHB11.02407282
59DAPK31.01640550
60MAP2K31.01591296
61MAPK111.00889044
62ITK1.00351675
63LATS20.99779251
64PRKG20.98547987
65CAMK2G0.98443621
66CSF1R0.98390229
67STK160.98308007
68TAOK30.96711438
69NTRK10.95425473
70CDK120.94540868
71JAK10.93874251
72CAMK10.92985688
73MAP2K20.90788277
74PDGFRA0.89214180
75AURKA0.88136688
76CSNK1G30.87771560
77PDK20.87556959
78PAK40.87113449
79EPHA40.86491944
80SGK30.85170461
81PRKD20.85044095
82MAP2K60.84163232
83MAPK150.84093763
84CSNK1A1L0.84050528
85LMTK20.82436012
86MAP3K120.82390138
87MINK10.81813688
88GRK60.80568388
89CAMK2B0.79511415
90ILK0.77855358
91PTK20.77662377
92CAMK40.77560761
93HIPK20.77239969
94HCK0.76515978
95PRKAA10.76418927
96LATS10.75236487
97CAMKK10.74891865
98DYRK1B0.74584824
99PAK60.72876090
100KIT0.72593311
101UHMK10.71988815
102MAP2K70.70483931
103STK240.69852591
104PHKG10.69478680
105PHKG20.69478680
106FGFR10.68771945
107GRK10.68575644
108JAK30.68300729
109DMPK0.68253221
110TAF10.67921606
111MTOR0.66087647
112EPHB20.65412800
113PAK10.65140199
114SYK0.64206055
115MAPK120.64020225
116MAP3K10.63894113
117CDK50.63460648
118TTN0.62659231
119RET0.62209254
120CDC42BPA0.61211222
121MAPKAPK30.60668076
122MOS0.60012537
123JAK20.59919989
124PINK10.58763039
125DYRK1A0.58287005
126PDGFRB0.58272135
127TYRO30.57729941
128PRKCH0.57344363
129MAP3K60.57166479
130CDK80.56010754
131ERBB20.55466415
132SCYL20.54835724
133PIK3CA0.54542075
134PTK2B0.53249725
135PDK10.50636351
136TBK10.49744962
137PRKCI0.49260429
138PDPK10.47787109
139CCNB10.47490963
140MAP3K30.46919332
141SGK20.46136396
142PRKCZ0.45719603
143EIF2AK10.45551377
144CSNK1G20.44942894
145NTRK30.44249082
146BMX0.44186926
147MAPK40.43108758
148MUSK0.43045378
149MYLK0.42068507
150RPS6KA40.41645706
151CSK0.41421815
152PRKACG0.40906200
153MAPKAPK50.40561650
154TAOK20.40477141
155IKBKE0.39986290
156SGK2230.39824453
157SGK4940.39824453
158CHUK0.39331365
159CDK70.39036866
160KSR20.38478213
161PRKCB0.37400495
162NME10.36853132
163SRC0.36685895
164AKT20.36668017
165RPS6KA20.35867861
166LCK0.35635075
167MAP3K80.35319127
168RPS6KA30.35298227
169CAMK2D0.35219501
170PAK30.34647248
171MARK10.33924884
172MET0.33772489

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.38552926
2Nitrogen metabolism_Homo sapiens_hsa009103.30667039
3Synaptic vesicle cycle_Homo sapiens_hsa047213.29642661
4Arginine biosynthesis_Homo sapiens_hsa002203.16738710
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77497415
6Fatty acid degradation_Homo sapiens_hsa000712.72721135
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.64893477
8Vitamin B6 metabolism_Homo sapiens_hsa007502.53405012
9Tryptophan metabolism_Homo sapiens_hsa003802.50452760
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44800225
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.20958294
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19131122
13Fatty acid metabolism_Homo sapiens_hsa012122.17932424
14Lysine degradation_Homo sapiens_hsa003102.13170881
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10093782
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.06837079
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05780532
18PPAR signaling pathway_Homo sapiens_hsa033201.95532256
19Butanoate metabolism_Homo sapiens_hsa006501.92208597
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89405349
21Phototransduction_Homo sapiens_hsa047441.86590794
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82421298
23Complement and coagulation cascades_Homo sapiens_hsa046101.82059395
24Bile secretion_Homo sapiens_hsa049761.73279166
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70770000
26Vibrio cholerae infection_Homo sapiens_hsa051101.67319464
27Peroxisome_Homo sapiens_hsa041461.66974630
28Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.61919634
29Oxidative phosphorylation_Homo sapiens_hsa001901.60899592
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60840277
31ABC transporters_Homo sapiens_hsa020101.60745303
32Propanoate metabolism_Homo sapiens_hsa006401.57619919
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.48839822
34Sulfur metabolism_Homo sapiens_hsa009201.39778908
35Alzheimers disease_Homo sapiens_hsa050101.37506029
36Selenocompound metabolism_Homo sapiens_hsa004501.37471493
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.37050923
38Histidine metabolism_Homo sapiens_hsa003401.36076749
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35543171
40Parkinsons disease_Homo sapiens_hsa050121.32135206
41Steroid biosynthesis_Homo sapiens_hsa001001.26327464
42beta-Alanine metabolism_Homo sapiens_hsa004101.25768030
43Proteasome_Homo sapiens_hsa030501.24834684
44DNA replication_Homo sapiens_hsa030301.24411330
45Phenylalanine metabolism_Homo sapiens_hsa003601.22229852
46Retinol metabolism_Homo sapiens_hsa008301.21227954
47Huntingtons disease_Homo sapiens_hsa050161.19570320
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18836982
49Chemical carcinogenesis_Homo sapiens_hsa052041.18222578
50Pyrimidine metabolism_Homo sapiens_hsa002401.18049476
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17320133
52Fatty acid elongation_Homo sapiens_hsa000621.16227175
53Galactose metabolism_Homo sapiens_hsa000521.16199776
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.12976304
55Amphetamine addiction_Homo sapiens_hsa050311.10918048
56Long-term potentiation_Homo sapiens_hsa047201.09138352
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.08473772
58Sulfur relay system_Homo sapiens_hsa041221.08050315
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07077741
60Tyrosine metabolism_Homo sapiens_hsa003501.06417122
61Cardiac muscle contraction_Homo sapiens_hsa042601.05971343
62Base excision repair_Homo sapiens_hsa034101.05575737
63Biosynthesis of amino acids_Homo sapiens_hsa012301.03765098
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.03555161
65Glutathione metabolism_Homo sapiens_hsa004801.01024312
66Fatty acid biosynthesis_Homo sapiens_hsa000610.99652574
67Prion diseases_Homo sapiens_hsa050200.99012249
68Dopaminergic synapse_Homo sapiens_hsa047280.98442173
69Glycerolipid metabolism_Homo sapiens_hsa005610.98369937
70Ribosome_Homo sapiens_hsa030100.96763549
71Pyruvate metabolism_Homo sapiens_hsa006200.96282731
72Starch and sucrose metabolism_Homo sapiens_hsa005000.95478350
73Morphine addiction_Homo sapiens_hsa050320.93832542
74Fat digestion and absorption_Homo sapiens_hsa049750.89318086
75Glioma_Homo sapiens_hsa052140.87057438
76Staphylococcus aureus infection_Homo sapiens_hsa051500.86402235
77Other glycan degradation_Homo sapiens_hsa005110.85676339
78Bladder cancer_Homo sapiens_hsa052190.85483773
79Caffeine metabolism_Homo sapiens_hsa002320.81327580
80Vitamin digestion and absorption_Homo sapiens_hsa049770.81107327
81Insulin resistance_Homo sapiens_hsa049310.81097357
82Endocytosis_Homo sapiens_hsa041440.79884123
83N-Glycan biosynthesis_Homo sapiens_hsa005100.79827746
84Cocaine addiction_Homo sapiens_hsa050300.79597544
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78313931
86Gastric acid secretion_Homo sapiens_hsa049710.78286221
87Glucagon signaling pathway_Homo sapiens_hsa049220.77440146
88Carbon metabolism_Homo sapiens_hsa012000.75663271
89VEGF signaling pathway_Homo sapiens_hsa043700.75167832
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75137394
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74009478
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73552911
93Circadian rhythm_Homo sapiens_hsa047100.71683696
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69870836
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67924935
96Nicotine addiction_Homo sapiens_hsa050330.67394016
97Lysosome_Homo sapiens_hsa041420.66053021
98Gap junction_Homo sapiens_hsa045400.64123053
99Purine metabolism_Homo sapiens_hsa002300.64023654
100Collecting duct acid secretion_Homo sapiens_hsa049660.63925364
101RNA polymerase_Homo sapiens_hsa030200.63913761
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63215734
103Sphingolipid metabolism_Homo sapiens_hsa006000.62856675
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62790046
105Cholinergic synapse_Homo sapiens_hsa047250.62309110
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61458762
107Fructose and mannose metabolism_Homo sapiens_hsa000510.60294555
108Primary immunodeficiency_Homo sapiens_hsa053400.59866023
109Oxytocin signaling pathway_Homo sapiens_hsa049210.59752507
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.59633590
111Glutamatergic synapse_Homo sapiens_hsa047240.59198866
112Insulin secretion_Homo sapiens_hsa049110.58482450
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58345341
114Calcium signaling pathway_Homo sapiens_hsa040200.57796896
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57794135
116GABAergic synapse_Homo sapiens_hsa047270.54955958
117Melanogenesis_Homo sapiens_hsa049160.54556754
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.53654240
119Oocyte meiosis_Homo sapiens_hsa041140.53636002
120Notch signaling pathway_Homo sapiens_hsa043300.53467936
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53239361
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51112006
123Estrogen signaling pathway_Homo sapiens_hsa049150.48719301
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.48287896
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.46781372
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45990106
127Type II diabetes mellitus_Homo sapiens_hsa049300.45115975
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.44727478
129ErbB signaling pathway_Homo sapiens_hsa040120.44639818
130Non-small cell lung cancer_Homo sapiens_hsa052230.43854209
131AMPK signaling pathway_Homo sapiens_hsa041520.43004366
132Arginine and proline metabolism_Homo sapiens_hsa003300.40424520
133GnRH signaling pathway_Homo sapiens_hsa049120.40190909
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37106683
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36846786
136Pentose phosphate pathway_Homo sapiens_hsa000300.35028123
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34791130
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33037129
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31445024
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30887446
141Circadian entrainment_Homo sapiens_hsa047130.29085355
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25399243
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21779735
144T cell receptor signaling pathway_Homo sapiens_hsa046600.21446883
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20805161
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19563179
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18331829
148Dilated cardiomyopathy_Homo sapiens_hsa054140.17233954
149Prolactin signaling pathway_Homo sapiens_hsa049170.17101878
150Metabolic pathways_Homo sapiens_hsa011000.16471102
151Insulin signaling pathway_Homo sapiens_hsa049100.16176205
152mTOR signaling pathway_Homo sapiens_hsa041500.16042520
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15098660
154Folate biosynthesis_Homo sapiens_hsa007900.15079512
155Salivary secretion_Homo sapiens_hsa049700.14545866
156Ovarian steroidogenesis_Homo sapiens_hsa049130.13839692

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