TGFBRAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)6.87915859
2definitive hemopoiesis (GO:0060216)5.54411510
3positive regulation of B cell differentiation (GO:0045579)5.47021957
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.67207292
5L-phenylalanine catabolic process (GO:0006559)4.67207292
6positive regulation of gamma-delta T cell activation (GO:0046645)4.65709339
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.36939539
8L-phenylalanine metabolic process (GO:0006558)4.36939539
9pinocytosis (GO:0006907)4.35416750
10alpha-linolenic acid metabolic process (GO:0036109)4.22246674
11aromatic amino acid family catabolic process (GO:0009074)3.76808361
12regulation of B cell differentiation (GO:0045577)3.74546868
13response to muramyl dipeptide (GO:0032495)3.72988159
14megakaryocyte development (GO:0035855)3.72066712
15B cell receptor signaling pathway (GO:0050853)3.70652194
16positive thymic T cell selection (GO:0045059)3.69552404
17mucosal-associated lymphoid tissue development (GO:0048537)3.67541054
18Peyers patch development (GO:0048541)3.67541054
19positive regulation of granulocyte differentiation (GO:0030854)3.61954915
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.54445410
21response to peptidoglycan (GO:0032494)3.51722837
22cysteine metabolic process (GO:0006534)3.46375093
23lysine metabolic process (GO:0006553)3.43974229
24lysine catabolic process (GO:0006554)3.43974229
25regulation of gamma-delta T cell differentiation (GO:0045586)3.43780242
26bile acid biosynthetic process (GO:0006699)3.39078520
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.36675861
283-UTR-mediated mRNA stabilization (GO:0070935)3.35701504
29regulation of erythrocyte differentiation (GO:0045646)3.34866367
30dicarboxylic acid biosynthetic process (GO:0043650)3.30822935
31protein carboxylation (GO:0018214)3.29662701
32peptidyl-glutamic acid carboxylation (GO:0017187)3.29662701
33regulation of cholesterol homeostasis (GO:2000188)3.29568750
34glyoxylate metabolic process (GO:0046487)3.27850760
35urea cycle (GO:0000050)3.19988251
36urea metabolic process (GO:0019627)3.19988251
37complement activation, alternative pathway (GO:0006957)3.19471588
38kynurenine metabolic process (GO:0070189)3.16289508
39glutamate metabolic process (GO:0006536)3.15321021
40dosage compensation (GO:0007549)3.14595643
41sulfur amino acid catabolic process (GO:0000098)3.13532663
42poly(A)+ mRNA export from nucleus (GO:0016973)3.12077526
43positive regulation of fatty acid beta-oxidation (GO:0032000)3.06005010
44formation of translation preinitiation complex (GO:0001731)3.05022841
45bile acid metabolic process (GO:0008206)3.04268534
46regulation of gamma-delta T cell activation (GO:0046643)3.01371817
47negative regulation of fibrinolysis (GO:0051918)2.99148802
48tryptophan catabolic process (GO:0006569)2.97264736
49indole-containing compound catabolic process (GO:0042436)2.97264736
50indolalkylamine catabolic process (GO:0046218)2.97264736
51nuclear pore complex assembly (GO:0051292)2.96253761
52regulation of protein activation cascade (GO:2000257)2.94755587
53mature B cell differentiation involved in immune response (GO:0002313)2.94662841
54cellular ketone body metabolic process (GO:0046950)2.93222354
55cellular modified amino acid catabolic process (GO:0042219)2.92055643
56regulation of B cell receptor signaling pathway (GO:0050855)2.90178066
57high-density lipoprotein particle remodeling (GO:0034375)2.90057863
58negative regulation of granulocyte differentiation (GO:0030853)2.87695385
59regulation of triglyceride catabolic process (GO:0010896)2.87161987
60phospholipid homeostasis (GO:0055091)2.84966430
61short-chain fatty acid metabolic process (GO:0046459)2.84344173
62drug catabolic process (GO:0042737)2.83512202
63nitrogen cycle metabolic process (GO:0071941)2.82900125
64DNA unwinding involved in DNA replication (GO:0006268)2.82261212
65cellular hyperosmotic response (GO:0071474)2.82126978
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81264907
67response to host (GO:0075136)2.81264907
68response to host defenses (GO:0052200)2.81264907
69tryptophan metabolic process (GO:0006568)2.81205453
70regulation of complement activation (GO:0030449)2.79786320
71response to host immune response (GO:0052572)2.79762666
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79762666
73plasma lipoprotein particle clearance (GO:0034381)2.79395695
74regulation of fatty acid beta-oxidation (GO:0031998)2.79319034
75homocysteine metabolic process (GO:0050667)2.79092260
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78493455
77positive regulation of lipid catabolic process (GO:0050996)2.78457368
78aspartate family amino acid catabolic process (GO:0009068)2.77345038
79regulation of leukocyte degranulation (GO:0043300)2.76182665
80regulation of monocyte differentiation (GO:0045655)2.75983884
81regulation of granulocyte differentiation (GO:0030852)2.75397146
82macroautophagy (GO:0016236)2.74748217
83mature B cell differentiation (GO:0002335)2.74731577
84mannose metabolic process (GO:0006013)2.73894027
85tyrosine metabolic process (GO:0006570)2.72943166
86regulation of histone H3-K9 methylation (GO:0051570)2.72684709
87regulation of fibrinolysis (GO:0051917)2.72509828
88immunoglobulin mediated immune response (GO:0016064)2.72075787
89regulation of RNA export from nucleus (GO:0046831)2.71221719
90reverse cholesterol transport (GO:0043691)2.70467625
91positive regulation of fatty acid oxidation (GO:0046321)2.70093483
92drug transmembrane transport (GO:0006855)2.69948554
93acetyl-CoA metabolic process (GO:0006084)2.68384174
94regulation of B cell apoptotic process (GO:0002902)2.67359737
95negative regulation of phagocytosis (GO:0050765)2.66868734
96negative regulation of sterol transport (GO:0032372)2.66394492
97negative regulation of cholesterol transport (GO:0032375)2.66394492
98mitotic sister chromatid cohesion (GO:0007064)2.65535665
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63964300
100alpha-amino acid catabolic process (GO:1901606)2.62491243
101cholesterol efflux (GO:0033344)2.62116524
102positive T cell selection (GO:0043368)2.62080487
103amino-acid betaine metabolic process (GO:0006577)2.61273103
104thymic T cell selection (GO:0045061)2.61037080
105coenzyme catabolic process (GO:0009109)2.60970836
106serine family amino acid catabolic process (GO:0009071)2.60655770
107aromatic amino acid family metabolic process (GO:0009072)2.59556575
1082-oxoglutarate metabolic process (GO:0006103)2.58083694
109acylglycerol homeostasis (GO:0055090)2.58009953
110triglyceride homeostasis (GO:0070328)2.58009953
111regulation of ARF protein signal transduction (GO:0032012)2.57736362
112spliceosomal tri-snRNP complex assembly (GO:0000244)2.57386597
113regulation of mast cell degranulation (GO:0043304)2.57195994
114natural killer cell differentiation (GO:0001779)2.55877277
115regulation of integrin activation (GO:0033623)2.54124209
116folic acid-containing compound biosynthetic process (GO:0009396)2.54005124
117interkinetic nuclear migration (GO:0022027)2.53885301
118ketone body metabolic process (GO:1902224)2.53495473
119cellular amino acid catabolic process (GO:0009063)2.52124164
120cellular response to exogenous dsRNA (GO:0071360)2.52070254
121DNA duplex unwinding (GO:0032508)2.51515690
122ethanol oxidation (GO:0006069)2.50570886
123ribosomal small subunit biogenesis (GO:0042274)2.50454466
124phospholipid efflux (GO:0033700)2.50089894
125dicarboxylic acid catabolic process (GO:0043649)2.49426780
126negative regulation of DNA repair (GO:0045738)2.49366304
127fatty-acyl-CoA biosynthetic process (GO:0046949)2.47783940
128B cell mediated immunity (GO:0019724)2.47040657
129protein localization to endosome (GO:0036010)2.46820647
130cellular response to interleukin-4 (GO:0071353)2.46451512
131positive regulation of interferon-alpha production (GO:0032727)2.45941159
132ribosomal small subunit assembly (GO:0000028)2.45490759
133regulation of myeloid leukocyte mediated immunity (GO:0002886)2.44659272
134regulation of histone H3-K4 methylation (GO:0051569)2.44478006
135modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42494949
136positive regulation by organism of defense response of other organism involved in symbiotic interact2.42494949
137modulation by symbiont of host immune response (GO:0052553)2.42494949
138positive regulation by symbiont of host defense response (GO:0052509)2.42494949
139modulation by symbiont of host defense response (GO:0052031)2.42494949
140modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42494949
141negative thymic T cell selection (GO:0045060)2.42401789
142negative regulation of lipase activity (GO:0060192)2.42400441
143protein-lipid complex remodeling (GO:0034368)2.41872757
144macromolecular complex remodeling (GO:0034367)2.41872757
145plasma lipoprotein particle remodeling (GO:0034369)2.41872757
146fatty acid beta-oxidation (GO:0006635)2.41242936
147positive regulation of histone H3-K4 methylation (GO:0051571)2.40565736
148protein-lipid complex assembly (GO:0065005)2.40417087
149exogenous drug catabolic process (GO:0042738)2.39931162
150fatty acid transmembrane transport (GO:1902001)2.38803144
151bile acid and bile salt transport (GO:0015721)2.38634685
152fatty acid oxidation (GO:0019395)2.38279063
153positive regulation of triglyceride metabolic process (GO:0090208)2.37522161
154nuclear pore organization (GO:0006999)2.37403523
155sodium ion export (GO:0071436)2.37326078
156DNA geometric change (GO:0032392)2.37009153
157ribosome assembly (GO:0042255)2.35571070
158thioester biosynthetic process (GO:0035384)2.35163535
159acyl-CoA biosynthetic process (GO:0071616)2.35163535
160B cell homeostasis (GO:0001782)2.35084881
161histone H3-K4 trimethylation (GO:0080182)2.34968999
162cholesterol homeostasis (GO:0042632)2.34164141
163regulation of translational termination (GO:0006449)2.33904033
164pore complex assembly (GO:0046931)2.33803261
165lipid oxidation (GO:0034440)2.33683162
166T cell homeostasis (GO:0043029)2.33653591
167very long-chain fatty acid metabolic process (GO:0000038)2.33458553
168sterol homeostasis (GO:0055092)2.33458246
169long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.31940902
170histamine secretion (GO:0001821)2.31839184
171folic acid metabolic process (GO:0046655)2.31360152
172positive regulation of glycogen biosynthetic process (GO:0045725)2.31294831
173plasma lipoprotein particle assembly (GO:0034377)2.30702686
174regulation of translation in response to stress (GO:0043555)2.30450050
175regulation of mast cell activation involved in immune response (GO:0033006)2.30213667
176regulation of bile acid biosynthetic process (GO:0070857)2.29996578
177fatty acid catabolic process (GO:0009062)2.29929605
178histone H3-K9 modification (GO:0061647)2.29704467
179monocarboxylic acid catabolic process (GO:0072329)2.29097419
180histone H3-K9 methylation (GO:0051567)2.28709321
181response to mercury ion (GO:0046689)2.28002631
182regulation of lipid catabolic process (GO:0050994)2.27383967
183negative regulation of B cell apoptotic process (GO:0002903)2.26763140
184positive regulation of protein import into nucleus, translocation (GO:0033160)2.26474324
185chaperone mediated protein folding requiring cofactor (GO:0051085)2.26420337
186regulation of histone H3-K27 methylation (GO:0061085)2.25117477
187positive regulation of interferon-beta production (GO:0032728)2.24967134
188regulation of fatty acid oxidation (GO:0046320)2.24940005
189negative regulation of mRNA processing (GO:0050686)2.24810369
190positive regulation of triglyceride biosynthetic process (GO:0010867)2.24053935
191mRNA transcription from RNA polymerase II promoter (GO:0042789)2.24046178
192UV protection (GO:0009650)2.23448884
193biotin metabolic process (GO:0006768)2.23287171
194negative regulation of mRNA metabolic process (GO:1903312)2.22720290
195regulation of nucleobase-containing compound transport (GO:0032239)2.22449426
196glucocorticoid receptor signaling pathway (GO:0042921)2.22135744
197snRNA metabolic process (GO:0016073)2.22007770
198positive regulation of B cell activation (GO:0050871)2.21341849
199endothelium development (GO:0003158)2.20704043
200stress fiber assembly (GO:0043149)2.20690972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87174816
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.95702959
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.27848172
4* MYC_22102868_ChIP-Seq_BL_Human4.01944570
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.84927285
6VDR_21846776_ChIP-Seq_THP-1_Human3.47796326
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.39314188
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.25608475
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.84506118
10SCL_19346495_ChIP-Seq_HPC-7_Human2.75035660
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.64940280
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.60691358
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40350236
14VDR_24763502_ChIP-Seq_THP-1_Human2.38616707
15* MYC_18555785_ChIP-Seq_MESCs_Mouse2.31213252
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30694002
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25397886
18* TCF7_22412390_ChIP-Seq_EML_Mouse2.23140818
19* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.16923497
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14943592
21CIITA_25753668_ChIP-Seq_RAJI_Human2.03710968
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95605893
23MAF_26560356_Chip-Seq_TH1_Human1.92242927
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91139103
25SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.81127267
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80355335
27SPI1_23547873_ChIP-Seq_NB4_Human1.76262245
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.74577306
29DROSHA_22980978_ChIP-Seq_HELA_Human1.73987597
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.73166764
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72606400
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.72067878
33UTX_26944678_Chip-Seq_JUKART_Human1.71982145
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71687778
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71421085
36* FOXA2_19822575_ChIP-Seq_HepG2_Human1.70361314
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69472224
38MYB_26560356_Chip-Seq_TH2_Human1.66205004
39MYB_26560356_Chip-Seq_TH1_Human1.63327439
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62062187
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59306750
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57180302
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57159664
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56165119
45* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55683497
46* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54859131
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54090543
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53257386
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53075180
50* ESR2_21235772_ChIP-Seq_MCF-7_Human1.51609648
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51114573
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49924886
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49889964
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49222162
55* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48576909
56TFEB_21752829_ChIP-Seq_HELA_Human1.46764878
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46512030
58ZNF263_19887448_ChIP-Seq_K562_Human1.45555340
59CLOCK_20551151_ChIP-Seq_293T_Human1.45275492
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44005149
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.43824017
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43350475
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42836640
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42003820
65* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40859637
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40121120
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39775734
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39513929
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.39249986
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39239965
71MAF_26560356_Chip-Seq_TH2_Human1.38064478
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37725801
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37668272
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37495028
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36782532
76KDM2B_26808549_Chip-Seq_K562_Human1.35908375
77* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34875348
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32797750
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32752231
80NCOR1_26117541_ChIP-Seq_K562_Human1.30802869
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.29538363
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28938613
83* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24731211
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.24410917
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24101049
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24101049
87KDM5A_27292631_Chip-Seq_BREAST_Human1.22282160
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22256364
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.22015324
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21915929
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21602479
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21355947
93* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20238082
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19076270
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18882101
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18191382
97FOXP3_21729870_ChIP-Seq_TREG_Human1.17703124
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17474005
99GBX2_23144817_ChIP-Seq_PC3_Human1.15162510
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14926615
101* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14748856
102GATA1_19941826_ChIP-Seq_K562_Human1.13936414
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13268752
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12998359
105RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12445710
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11366897
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10767941
108LXR_22292898_ChIP-Seq_THP-1_Human1.09078475
109AHR_22903824_ChIP-Seq_MCF-7_Human1.09023460
110KDM2B_26808549_Chip-Seq_DND41_Human1.08792384
111* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08593786
112XRN2_22483619_ChIP-Seq_HELA_Human1.08114684
113GATA1_22025678_ChIP-Seq_K562_Human1.06786832
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06752710
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06572471
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.06443220
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06423111
118* SPI1_23127762_ChIP-Seq_K562_Human1.06405652
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06332058
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05544793
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05483798
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05147504
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04008494
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03856101
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03152375
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02633223
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02479302
128AR_21572438_ChIP-Seq_LNCaP_Human1.02472803
129FOXM1_23109430_ChIP-Seq_U2OS_Human1.02331691
130RXR_22108803_ChIP-Seq_LS180_Human1.02033746
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.99878045
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.99878045
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99367297
134RUNX_20019798_ChIP-Seq_JUKART_Human0.99096624
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98695025
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98639964
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.98465350
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.98450340
139SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98193697
140STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97754057
141JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97349968
142* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96358088
143SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96315402
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.96255989
145DCP1A_22483619_ChIP-Seq_HELA_Human0.95839186
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95828927
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.95553765
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.95096719
149IRF8_27001747_Chip-Seq_BMDM_Mouse0.95045674
150JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94285384
151PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94029911
152* RACK7_27058665_Chip-Seq_MCF-7_Human0.94019048
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93347821
154TTF2_22483619_ChIP-Seq_HELA_Human0.93271152
155* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92970316
156DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92565527
157CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92549561
158PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92056138
159P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91614252
160* GABP_19822575_ChIP-Seq_HepG2_Human0.91441468
161ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90906342
162ELF1_20517297_ChIP-Seq_JURKAT_Human0.90665710
163TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90512322
164* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89785513
165* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89093660
166PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89065771
167RNF2_27304074_Chip-Seq_ESCs_Mouse0.88843733
168SOX2_21211035_ChIP-Seq_LN229_Gbm0.88501634
169REST_21632747_ChIP-Seq_MESCs_Mouse0.88306921
170NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88072396
171NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88072396
172SMAD4_21741376_ChIP-Seq_HESCs_Human0.87878481
173CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87677234
174GATA2_19941826_ChIP-Seq_K562_Human0.87201938
175* ESR1_21235772_ChIP-Seq_MCF-7_Human0.83448039
176GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82983825
177AR_19668381_ChIP-Seq_PC3_Human0.82958131
178PIAS1_25552417_ChIP-Seq_VCAP_Human0.82774712
179REST_18959480_ChIP-ChIP_MESCs_Mouse0.82395792
180TP53_16413492_ChIP-PET_HCT116_Human0.81659661
181KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81650916
182CREB1_26743006_Chip-Seq_LNCaP_Human0.81226760
183SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80380936
184GATA1_19941827_ChIP-Seq_MEL_Mouse0.79968583
185EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77194219
186FOXA1_25552417_ChIP-Seq_VCAP_Human0.75853006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.48742560
2MP0005360_urolithiasis5.07016827
3MP0002396_abnormal_hematopoietic_system4.89981725
4MP0005365_abnormal_bile_salt4.15778262
5MP0005085_abnormal_gallbladder_physiolo3.95149699
6MP0003252_abnormal_bile_duct3.43738081
7MP0004808_abnormal_hematopoietic_stem3.29272612
8MP0008875_abnormal_xenobiotic_pharmacok3.25381314
9MP0008057_abnormal_DNA_replication3.22820740
10MP0009840_abnormal_foam_cell2.83173008
11MP0005464_abnormal_platelet_physiology2.66422982
12MP0010329_abnormal_lipoprotein_level2.66142830
13MP0002877_abnormal_melanocyte_morpholog2.65354428
14MP0009278_abnormal_bone_marrow2.64800719
15MP0005397_hematopoietic_system_phenotyp2.51654308
16MP0001545_abnormal_hematopoietic_system2.51654308
17MP0003191_abnormal_cellular_cholesterol2.49590842
18MP0003763_abnormal_thymus_physiology2.48339950
19MP0005075_abnormal_melanosome_morpholog2.31443610
20MP0004859_abnormal_synaptic_plasticity2.31128965
21MP0001835_abnormal_antigen_presentation2.23806615
22MP0005083_abnormal_biliary_tract2.22377198
23MP0009780_abnormal_chondrocyte_physiolo2.16427311
24MP0003195_calcinosis2.09547181
25MP0003705_abnormal_hypodermis_morpholog2.06210778
26MP0002398_abnormal_bone_marrow2.01259952
27MP0003690_abnormal_glial_cell2.01235362
28MP0010094_abnormal_chromosome_stability2.01172634
29MP0003329_amyloid_beta_deposits2.00637112
30MP0005332_abnormal_amino_acid1.97230431
31MP0003436_decreased_susceptibility_to1.96627444
32MP0002118_abnormal_lipid_homeostasis1.96243463
33MP0000015_abnormal_ear_pigmentation1.92302116
34MP0004130_abnormal_muscle_cell1.90773380
35MP0001666_abnormal_nutrient_absorption1.88462814
36MP0004185_abnormal_adipocyte_glucose1.88061021
37MP0000604_amyloidosis1.86606263
38MP0005058_abnormal_lysosome_morphology1.84678398
39MP0005076_abnormal_cell_differentiation1.83992694
40MP0002138_abnormal_hepatobiliary_system1.81674350
41MP0003111_abnormal_nucleus_morphology1.78866289
42MP0000685_abnormal_immune_system1.73211590
43MP0008007_abnormal_cellular_replicative1.69619109
44MP0002166_altered_tumor_susceptibility1.69360075
45MP0010352_gastrointestinal_tract_polyps1.68678643
46MP0008961_abnormal_basal_metabolism1.68383703
47MP0000465_gastrointestinal_hemorrhage1.68021611
48MP0003300_gastrointestinal_ulcer1.66650150
49MP0000609_abnormal_liver_physiology1.64600428
50MP0000689_abnormal_spleen_morphology1.59173230
51MP0002420_abnormal_adaptive_immunity1.56221483
52MP0000703_abnormal_thymus_morphology1.53220798
53MP0004270_analgesia1.53185080
54MP0002722_abnormal_immune_system1.51597380
55MP0001819_abnormal_immune_cell1.51473988
56MP0001800_abnormal_humoral_immune1.50410862
57MP0002009_preneoplasia1.49788680
58MP0002429_abnormal_blood_cell1.49561955
59MP0003172_abnormal_lysosome_physiology1.47604992
60MP0000716_abnormal_immune_system1.45566886
61MP0001853_heart_inflammation1.44931324
62MP0002909_abnormal_adrenal_gland1.44862082
63MP0003077_abnormal_cell_cycle1.44293358
64MP0003868_abnormal_feces_composition1.43068732
65MP0002419_abnormal_innate_immunity1.42474725
66MP0005000_abnormal_immune_tolerance1.41117888
67MP0005666_abnormal_adipose_tissue1.40617460
68MP0000350_abnormal_cell_proliferation1.40549111
69MP0004043_abnormal_pH_regulation1.40248966
70MP0002452_abnormal_antigen_presenting1.39953559
71MP0004019_abnormal_vitamin_homeostasis1.35934848
72MP0000920_abnormal_myelination1.34105843
73MP0002019_abnormal_tumor_incidence1.32621932
74MP0010234_abnormal_vibrissa_follicle1.32564230
75MP0002723_abnormal_immune_serum1.29354016
76MP0005167_abnormal_blood-brain_barrier1.26106183
77MP0005584_abnormal_enzyme/coenzyme_acti1.24565059
78MP0005409_darkened_coat_color1.19825699
79MP0005375_adipose_tissue_phenotype1.18983079
80MP0005670_abnormal_white_adipose1.17643318
81MP0005174_abnormal_tail_pigmentation1.17550282
82MP0002006_tumorigenesis1.16992231
83MP0005025_abnormal_response_to1.15820605
84MP0003075_altered_response_to1.14740175
85MP0009643_abnormal_urine_homeostasis1.14725027
86MP0003806_abnormal_nucleotide_metabolis1.14606883
87MP0003566_abnormal_cell_adhesion1.14293227
88MP0000371_diluted_coat_color1.13186766
89MP0003633_abnormal_nervous_system1.11898778
90MP0003635_abnormal_synaptic_transmissio1.11722666
91MP0005621_abnormal_cell_physiology1.11390808
92MP0004957_abnormal_blastocyst_morpholog1.10032879
93MP0008058_abnormal_DNA_repair1.09449994
94MP0002405_respiratory_system_inflammati1.08121962
95MP0001730_embryonic_growth_arrest1.07948976
96MP0005451_abnormal_body_composition1.07436751
97MP0002078_abnormal_glucose_homeostasis1.06624178
98MP0003303_peritoneal_inflammation1.06132740
99MP0005387_immune_system_phenotype1.05539433
100MP0001790_abnormal_immune_system1.05539433
101MP0002837_dystrophic_cardiac_calcinosis1.05215228
102MP0004381_abnormal_hair_follicle1.04851447
103MP0000313_abnormal_cell_death1.04319921
104MP0004885_abnormal_endolymph1.04231070
105MP0002971_abnormal_brown_adipose1.03684263
106MP0005319_abnormal_enzyme/_coenzyme1.02356984
107MP0009333_abnormal_splenocyte_physiolog1.02080497
108MP0003943_abnormal_hepatobiliary_system1.01869700
109MP0000003_abnormal_adipose_tissue1.01649818
110MP0001851_eye_inflammation1.00843383
111MP0001873_stomach_inflammation1.00708737
112MP0003693_abnormal_embryo_hatching1.00675075
113MP0000490_abnormal_crypts_of1.00289203
114MP0005535_abnormal_body_temperature1.00178193
115MP0002064_seizures0.97963650
116MP0003984_embryonic_growth_retardation0.97826091
117MP0004947_skin_inflammation0.97119418
118MP0000681_abnormal_thyroid_gland0.96476032
119MP0003828_pulmonary_edema0.96413551
120MP0009931_abnormal_skin_appearance0.95577449
121MP0005501_abnormal_skin_physiology0.95288689
122MP0003045_fibrosis0.94678922
123MP0002086_abnormal_extraembryonic_tissu0.94120816
124MP0003786_premature_aging0.93375943
125MP0005384_cellular_phenotype0.92853933
126MP0000747_muscle_weakness0.92753730
127MP0004858_abnormal_nervous_system0.92382742
128MP0002080_prenatal_lethality0.91668665
129MP0001672_abnormal_embryogenesis/_devel0.90637941
130MP0005380_embryogenesis_phenotype0.90637941
131MP0002088_abnormal_embryonic_growth/wei0.90534728
132MP0002090_abnormal_vision0.90407299
133MP0001765_abnormal_ion_homeostasis0.90303570
134MP0010368_abnormal_lymphatic_system0.90108428
135MP0000372_irregular_coat_pigmentation0.87898987
136MP0005334_abnormal_fat_pad0.87802974
137MP0000013_abnormal_adipose_tissue0.87417379
138MP0004510_myositis0.86774701
139MP0002796_impaired_skin_barrier0.85617228
140MP0001756_abnormal_urination0.84629692
141MP0001915_intracranial_hemorrhage0.84541581
142MP0002254_reproductive_system_inflammat0.83945914
143MP0003631_nervous_system_phenotype0.82953470
144MP0002970_abnormal_white_adipose0.82443219
145MP0002063_abnormal_learning/memory/cond0.82167097
146MP0009115_abnormal_fat_cell0.81815439
147MP0004134_abnormal_chest_morphology0.81786621
148MP0003634_abnormal_glial_cell0.81332412
149MP0008874_decreased_physiological_sensi0.80907278
150MP0002060_abnormal_skin_morphology0.78608523
151MP0002928_abnormal_bile_duct0.78398641
152MP0009379_abnormal_foot_pigmentation0.78381842
153MP0002998_abnormal_bone_remodeling0.78322440
154MP0003453_abnormal_keratinocyte_physiol0.78279782
155MP0002075_abnormal_coat/hair_pigmentati0.78100548
156MP0001697_abnormal_embryo_size0.77812174
157MP0004782_abnormal_surfactant_physiolog0.77788907
158MP0010155_abnormal_intestine_physiology0.77232503
159MP0001661_extended_life_span0.76822480
160MP0000569_abnormal_digit_pigmentation0.75529726
161MP0002148_abnormal_hypersensitivity_rea0.75216586
162MP0003656_abnormal_erythrocyte_physiolo0.74464495
163MP0000579_abnormal_nail_morphology0.72208556
164MP0005448_abnormal_energy_balance0.70824886
165MP0003632_abnormal_nervous_system0.68830572
166MP0002168_other_aberrant_phenotype0.68375818
167MP0000598_abnormal_liver_morphology0.66566853
168MP0002229_neurodegeneration0.65761517
169MP0009745_abnormal_behavioral_response0.64377222
170MP0003183_abnormal_peptide_metabolism0.64186250
171MP0001486_abnormal_startle_reflex0.64129526
172MP0009642_abnormal_blood_homeostasis0.63148197
173MP0000230_abnormal_systemic_arterial0.62904029
174MP0002822_catalepsy0.62079135
175MP0005636_abnormal_mineral_homeostasis0.61496610
176MP0001944_abnormal_pancreas_morphology0.60858180
177MP0005220_abnormal_exocrine_pancreas0.60222425
178MP0002572_abnormal_emotion/affect_behav0.57716547
179MP0003953_abnormal_hormone_level0.57684618
180MP0008569_lethality_at_weaning0.57558181
181MP0005166_decreased_susceptibility_to0.57165157
182MP0002896_abnormal_bone_mineralization0.56765722
183MP0000639_abnormal_adrenal_gland0.55368797
184MP0002069_abnormal_eating/drinking_beha0.54617196
185MP0009046_muscle_twitch0.53330652
186MP0001501_abnormal_sleep_pattern0.53017215
187MP0002136_abnormal_kidney_physiology0.51150587
188MP0010678_abnormal_skin_adnexa0.50842363

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.81694133
2Intrahepatic cholestasis (HP:0001406)4.26110961
3Complement deficiency (HP:0004431)4.10214057
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.09600859
5Xanthomatosis (HP:0000991)4.07642841
6Acute lymphatic leukemia (HP:0006721)3.98847069
7Acute myeloid leukemia (HP:0004808)3.76542397
8Agammaglobulinemia (HP:0004432)3.68450449
9Thrombocytosis (HP:0001894)3.67771516
10Panhypogammaglobulinemia (HP:0003139)3.65700310
11Prolonged bleeding time (HP:0003010)3.61654599
12Hyperlipoproteinemia (HP:0010980)3.55919955
13Ketosis (HP:0001946)3.46295435
14Recurrent viral infections (HP:0004429)3.30963933
15Ketoacidosis (HP:0001993)3.29284018
16Neurofibrillary tangles (HP:0002185)3.27703279
17Abnormality of monocarboxylic acid metabolism (HP:0010996)3.22917844
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.22497085
19Cellulitis (HP:0100658)3.15534141
20Cerebral inclusion bodies (HP:0100314)3.07328453
21Epidermoid cyst (HP:0200040)3.07195271
22Viral hepatitis (HP:0006562)3.05152435
23Hypoglycemic coma (HP:0001325)2.90474897
24Gout (HP:0001997)2.86171956
25Impaired platelet aggregation (HP:0003540)2.80083200
26Abnormal platelet function (HP:0011869)2.80083200
27Fatigue (HP:0012378)2.77466363
28Systemic lupus erythematosus (HP:0002725)2.74899561
29Abnormality of complement system (HP:0005339)2.72327239
30Epistaxis (HP:0000421)2.71354711
31Thoracic kyphosis (HP:0002942)2.70708546
32Hypoalphalipoproteinemia (HP:0003233)2.70669780
33Abnormality of the common coagulation pathway (HP:0010990)2.67797783
34Hyperammonemia (HP:0001987)2.65545182
35Prolonged partial thromboplastin time (HP:0003645)2.64078250
36Abnormality of the thoracic spine (HP:0100711)2.60752388
37Hypobetalipoproteinemia (HP:0003563)2.58824660
38Abnormality of the fingertips (HP:0001211)2.57900435
39Broad face (HP:0000283)2.55738782
40Recurrent fungal infections (HP:0002841)2.54127673
41Abnormality of glycine metabolism (HP:0010895)2.54113390
42Abnormality of serine family amino acid metabolism (HP:0010894)2.54113390
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.53553410
44Skin nodule (HP:0200036)2.52385847
45Hyperacusis (HP:0010780)2.51677053
46Increased IgE level (HP:0003212)2.51334109
47Colitis (HP:0002583)2.50101330
48Petechiae (HP:0000967)2.49037512
49Gastrointestinal inflammation (HP:0004386)2.48797051
50Hyperglycinuria (HP:0003108)2.46667150
51Supranuclear gaze palsy (HP:0000605)2.46435825
52Spondylolisthesis (HP:0003302)2.46068560
53Sensorimotor neuropathy (HP:0007141)2.44202880
54Myocardial infarction (HP:0001658)2.44100371
55Hypolipoproteinemia (HP:0010981)2.43932315
56Abnormal platelet volume (HP:0011876)2.42011469
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.39015849
58Hyperglycinemia (HP:0002154)2.38746568
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.37187474
60Aplasia/Hypoplasia of the thymus (HP:0010515)2.35368496
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33701421
62Asymmetry of the thorax (HP:0001555)2.33126520
63Autoimmune hemolytic anemia (HP:0001890)2.31723806
64Recurrent cutaneous fungal infections (HP:0011370)2.30003809
65Chronic mucocutaneous candidiasis (HP:0002728)2.30003809
66Hypercholesterolemia (HP:0003124)2.28720430
67B lymphocytopenia (HP:0010976)2.27687544
68Joint hemorrhage (HP:0005261)2.24970554
69Polygenic inheritance (HP:0010982)2.24579883
70Turricephaly (HP:0000262)2.24055055
71Hypoglycemic seizures (HP:0002173)2.23508063
72Meningitis (HP:0001287)2.23049293
73Mitral stenosis (HP:0001718)2.21572419
74Increased mean platelet volume (HP:0011877)2.21502058
75Glomerulonephritis (HP:0000099)2.21491160
76Dysostosis multiplex (HP:0000943)2.21231105
77Abnormality of B cell number (HP:0010975)2.20967734
78Aplastic anemia (HP:0001915)2.19952040
79Intention tremor (HP:0002080)2.19878623
80Abnormality of purine metabolism (HP:0004352)2.19784179
81Retinal atrophy (HP:0001105)2.17577121
82Inflammation of the large intestine (HP:0002037)2.16736592
83Abnormality of T cell physiology (HP:0011840)2.16474068
84Hyperinsulinemic hypoglycemia (HP:0000825)2.15659121
85Granulocytopenia (HP:0001913)2.14004552
86Abnormality of oral frenula (HP:0000190)2.13121763
87Progressive muscle weakness (HP:0003323)2.10640346
88Axonal loss (HP:0003447)2.10438558
89Spinal cord lesions (HP:0100561)2.10419742
90Syringomyelia (HP:0003396)2.10419742
91Mucopolysacchariduria (HP:0008155)2.09067627
92Urinary glycosaminoglycan excretion (HP:0003541)2.09067627
93Global brain atrophy (HP:0002283)2.09018277
94Action tremor (HP:0002345)2.08993430
95Abnormality of polysaccharide metabolism (HP:0011012)2.08185303
96Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08185303
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08185303
98Microvesicular hepatic steatosis (HP:0001414)2.07514539
99Chronic obstructive pulmonary disease (HP:0006510)2.07330093
100Obstructive lung disease (HP:0006536)2.07330093
101Ankyloglossia (HP:0010296)2.07001600
102Hyperglycemia (HP:0003074)2.04808066
103Verrucae (HP:0200043)2.04598766
104Papilloma (HP:0012740)2.04598766
105Fat malabsorption (HP:0002630)2.04232133
106Ocular albinism (HP:0001107)2.03747988
107Abnormality of the Achilles tendon (HP:0005109)2.03216506
108Progressive external ophthalmoplegia (HP:0000590)2.00237455
109Neuronal loss in central nervous system (HP:0002529)2.00053238
110Spontaneous hematomas (HP:0007420)1.99117938
111Abnormality of the intrinsic pathway (HP:0010989)1.98392048
112Macroorchidism (HP:0000053)1.98079832
113Deep palmar crease (HP:0006191)1.98060052
114Myelodysplasia (HP:0002863)1.97859671
115Postural instability (HP:0002172)1.97559027
116Hepatitis (HP:0012115)1.97179816
117Lymphangioma (HP:0100764)1.96745715
118Amyloidosis (HP:0011034)1.96027069
119Elevated erythrocyte sedimentation rate (HP:0003565)1.94378907
120Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94356514
121Urethral obstruction (HP:0000796)1.94230185
122Conjugated hyperbilirubinemia (HP:0002908)1.94226495
123Delayed CNS myelination (HP:0002188)1.93537330
124Status epilepticus (HP:0002133)1.93449538
125Late onset (HP:0003584)1.93212705
126Esophageal varix (HP:0002040)1.91824435
127Osteomyelitis (HP:0002754)1.90047937
128Hypertensive crisis (HP:0100735)1.89909922
129Albinism (HP:0001022)1.89819055
130Abnormality of the thymus (HP:0000777)1.89646365
131Cerebral aneurysm (HP:0004944)1.88776320
132Prominent nose (HP:0000448)1.87472714
133Cutis marmorata (HP:0000965)1.86698721
134Hemiplegia (HP:0002301)1.85871981
135Abnormality of the prostate (HP:0008775)1.85668410
136Abnormality of the columella (HP:0009929)1.84808137
137Visceral angiomatosis (HP:0100761)1.84508809
138Increased CSF protein (HP:0002922)1.84057395
139Poikiloderma (HP:0001029)1.83624865
140Broad metatarsal (HP:0001783)1.83543469
141Termporal pattern (HP:0011008)1.82393072
142Insidious onset (HP:0003587)1.82393072
143Impaired proprioception (HP:0010831)1.80396556
144Abnormality of fatty-acid metabolism (HP:0004359)1.78733360
145Increased cerebral lipofuscin (HP:0011813)1.78548086
146Flat acetabular roof (HP:0003180)1.78511886
147Gingival bleeding (HP:0000225)1.78417060
148Hepatocellular carcinoma (HP:0001402)1.77479561
149Long eyelashes (HP:0000527)1.76606383
150Teleangiectasia of the skin (HP:0100585)1.76523250
151Hyperthyroidism (HP:0000836)1.76140751
152Spastic tetraparesis (HP:0001285)1.75661527
153Peripheral demyelination (HP:0011096)1.75317023
154Hemorrhage of the eye (HP:0011885)1.74662522
155Thickened calvaria (HP:0002684)1.74588617
156Visual hallucinations (HP:0002367)1.73926637
157Seborrheic dermatitis (HP:0001051)1.73886471
158Pustule (HP:0200039)1.73738326
159Neonatal onset (HP:0003623)1.73244423
160Trismus (HP:0000211)1.73110843
161Hemangiomatosis (HP:0007461)1.72979607
162Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72305000
163Polycythemia (HP:0001901)1.71894647
164Dysmetria (HP:0001310)1.71639305
165Deep philtrum (HP:0002002)1.69508498
166Spastic gait (HP:0002064)1.69445557
167Sparse scalp hair (HP:0002209)1.68787438
168Basal cell carcinoma (HP:0002671)1.68329105
169Upper limb amyotrophy (HP:0009129)1.68184106
170Distal upper limb amyotrophy (HP:0007149)1.68184106
171Recurrent abscess formation (HP:0002722)1.68095216
172Abnormality of the right ventricle (HP:0001707)1.68026656
173Neoplasm of the adrenal cortex (HP:0100641)1.67464468
174Nephritis (HP:0000123)1.66577974
175Skin ulcer (HP:0200042)1.66230031
176Impaired social interactions (HP:0000735)1.65238649
177Abnormal social behavior (HP:0012433)1.65238649
178Squamous cell carcinoma (HP:0002860)1.64398272
179Hyporeflexia of lower limbs (HP:0002600)1.64292092
180Gastrointestinal stroma tumor (HP:0100723)1.64283185
181Slow saccadic eye movements (HP:0000514)1.63556490
182Heterotopia (HP:0002282)1.63428495
183Delayed closure of the anterior fontanelle (HP:0001476)1.63419811
184Urticaria (HP:0001025)1.63166434
185Dysmetric saccades (HP:0000641)1.63125678
186Hyperuricemia (HP:0002149)1.62930741
187Increased purine levels (HP:0004368)1.62930741
188Focal seizures (HP:0007359)1.62919188
189Increased circulating renin level (HP:0000848)1.62904589
190Torticollis (HP:0000473)1.62699829
191Abnormal gallbladder morphology (HP:0012437)1.62555728
192Stroke (HP:0001297)1.62444221
193Autoimmune thrombocytopenia (HP:0001973)1.61934621
194Coarse hair (HP:0002208)1.61659717
195Multiple enchondromatosis (HP:0005701)1.60125891
196High pitched voice (HP:0001620)1.59942234
197Craniofacial hyperostosis (HP:0004493)1.59409136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.62062286
2CDK123.53793689
3PRPF4B3.29768163
4MAP2K33.02566225
5SMG12.88376541
6SCYL22.76512540
7KIT2.41471427
8ERN12.39700280
9MAP4K12.27430674
10SIK12.21354828
11MAP3K92.13955945
12FLT32.10570832
13NME22.04950306
14CAMK1G2.04451969
15FGFR21.98822364
16RIPK11.82318265
17DAPK21.80224468
18CAMK1D1.78186300
19BTK1.76147656
20KSR21.70015000
21IRAK31.70007546
22TAOK31.69806340
23LATS11.67179723
24FGFR41.57938300
25EPHB11.54688011
26WNK31.53272578
27CSF1R1.51742250
28INSRR1.50855126
29RPS6KB21.50721448
30PAK61.49816542
31NTRK11.46989625
32PTK61.45832556
33TEC1.45467674
34WNK41.45182500
35MAP3K21.44107459
36MAP3K101.43733392
37MAP2K41.42044335
38MAP3K141.36625341
39TYRO31.36466321
40PRKD31.35520882
41CDK61.34871077
42TBK11.34325028
43RET1.31313761
44EIF2AK31.31101406
45PKN21.30101158
46PRKCH1.29684154
47CDK41.26461995
48EPHA41.26173337
49MAP3K71.25348524
50SYK1.23421004
51BRD41.22014791
52BCKDK1.20833076
53OXSR11.20129492
54ICK1.19750379
55TGFBR21.15945159
56ITK1.15656688
57ZAP701.15373195
58PIM21.14864466
59WNK11.14538907
60STK391.13777791
61PRKD21.12576576
62JAK31.09407877
63TRPM71.08668340
64NTRK31.08273589
65MATK1.07015651
66PDGFRA1.07002209
67MAP3K31.06925679
68CDK71.06056618
69MAPK151.03942837
70JAK11.03924758
71STK381.03840696
72SGK31.03274712
73MAPK111.03055718
74TNK21.02664292
75PDPK11.01799416
76MAP3K40.99476226
77MAP3K130.98638822
78CDC70.98311690
79CAMKK10.96869602
80MAP2K20.96809470
81STK110.96485300
82RPS6KL10.96046221
83RPS6KC10.96046221
84SGK2230.95682276
85SGK4940.95682276
86MARK10.95610774
87DMPK0.93569728
88MET0.93214134
89FRK0.91242265
90PDGFRB0.90834850
91JAK20.89246054
92RPS6KA20.87972836
93PHKG10.86251462
94PHKG20.86251462
95PDK10.85592839
96PTK20.85061004
97HCK0.84661851
98PASK0.84138645
99SIK20.83311275
100TAOK10.82785697
101MARK20.82462932
102BMPR20.82360810
103PAK30.80201728
104PAK20.79912011
105CDK90.78823395
106LMTK20.78534286
107TTN0.77428186
108RPS6KA60.76890583
109IKBKB0.76865352
110PRKAA20.76241098
111NTRK20.74869211
112CDK50.74600342
113ATR0.73498818
114PRKD10.73245025
115PKN10.70244916
116FGFR30.69593932
117ERBB40.68739969
118PRKCZ0.66755463
119MINK10.66486092
120MAP3K10.66375609
121CDK80.66078321
122IRAK40.65897071
123PRKAA10.65365321
124BMX0.64474303
125MTOR0.64150547
126IRAK20.63871156
127MAP3K60.63308308
128LCK0.62784327
129GRK60.62312286
130CHEK10.61984129
131FES0.61244685
132MAPK120.60669363
133SGK20.60584084
134KSR10.59900982
135PIM10.59674554
136LATS20.58269219
137EIF2AK20.58225431
138EEF2K0.57465457
139TAOK20.57447202
140HIPK20.57134862
141ERBB20.57084847
142CLK10.56956204
143RIPK40.56133624
144DAPK10.55976658
145GSK3A0.55279007
146CSNK1G20.53584364
147FYN0.53327274
148IKBKE0.52280822
149TYK20.51726513
150SGK10.50878138
151PTK2B0.50111903
152FER0.49937987
153CDK20.48942440
154IRAK10.48610635
155MAP3K110.47137520
156MAPK30.46836394
157CAMK40.46381619
158MARK30.46348504
159LYN0.46216650
160EPHB20.46046935
161STK100.45904026
162ALK0.45624930
163CSNK1A1L0.44900077
164MAP3K80.44739947
165FGR0.42789991
166CHEK20.41942756
167TGFBR10.39669952
168RPS6KA10.39317087
169VRK20.39206630
170RPS6KB10.38959494
171MKNK10.38567901

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.23596497
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.91644336
3Acute myeloid leukemia_Homo sapiens_hsa052212.52753323
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51376710
5Other glycan degradation_Homo sapiens_hsa005112.48300429
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.43181062
7B cell receptor signaling pathway_Homo sapiens_hsa046622.41834683
8Arginine biosynthesis_Homo sapiens_hsa002202.39279869
9Chronic myeloid leukemia_Homo sapiens_hsa052202.26281139
10DNA replication_Homo sapiens_hsa030302.13879994
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.07666282
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00473049
13Asthma_Homo sapiens_hsa053101.99225693
14Non-small cell lung cancer_Homo sapiens_hsa052231.94870188
15Butanoate metabolism_Homo sapiens_hsa006501.90886324
16Fatty acid degradation_Homo sapiens_hsa000711.89456886
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84858667
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.79649642
19Leishmaniasis_Homo sapiens_hsa051401.78128288
20Allograft rejection_Homo sapiens_hsa053301.77830290
21Bile secretion_Homo sapiens_hsa049761.75944375
22Tryptophan metabolism_Homo sapiens_hsa003801.75886811
23Complement and coagulation cascades_Homo sapiens_hsa046101.73820896
24Non-homologous end-joining_Homo sapiens_hsa034501.72594596
25Pancreatic cancer_Homo sapiens_hsa052121.70794678
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70515901
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68478509
28Fatty acid metabolism_Homo sapiens_hsa012121.64997982
29PPAR signaling pathway_Homo sapiens_hsa033201.63706003
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60437998
31Herpes simplex infection_Homo sapiens_hsa051681.58001137
32Autoimmune thyroid disease_Homo sapiens_hsa053201.57092995
33Platelet activation_Homo sapiens_hsa046111.47702254
34Base excision repair_Homo sapiens_hsa034101.47255157
35Propanoate metabolism_Homo sapiens_hsa006401.47024949
36Type I diabetes mellitus_Homo sapiens_hsa049401.41391206
37Graft-versus-host disease_Homo sapiens_hsa053321.41216214
38Hepatitis B_Homo sapiens_hsa051611.40008343
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39761129
40Viral myocarditis_Homo sapiens_hsa054161.36274399
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35916816
42Staphylococcus aureus infection_Homo sapiens_hsa051501.34771787
43Primary immunodeficiency_Homo sapiens_hsa053401.33940676
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33633592
45Influenza A_Homo sapiens_hsa051641.32113292
46Caffeine metabolism_Homo sapiens_hsa002321.31622335
47Bladder cancer_Homo sapiens_hsa052191.31455444
48Toxoplasmosis_Homo sapiens_hsa051451.30863992
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29975415
50Measles_Homo sapiens_hsa051621.29828030
51Thyroid cancer_Homo sapiens_hsa052161.26069121
52Colorectal cancer_Homo sapiens_hsa052101.21680163
53Peroxisome_Homo sapiens_hsa041461.20385474
54ABC transporters_Homo sapiens_hsa020101.20019841
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19691214
56Lysine degradation_Homo sapiens_hsa003101.17404360
57Antigen processing and presentation_Homo sapiens_hsa046121.16251358
58Epstein-Barr virus infection_Homo sapiens_hsa051691.16184675
59Small cell lung cancer_Homo sapiens_hsa052221.15161919
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14851135
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14663795
62Spliceosome_Homo sapiens_hsa030401.14428531
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.13145376
64HTLV-I infection_Homo sapiens_hsa051661.10467675
65RNA transport_Homo sapiens_hsa030131.07870329
66VEGF signaling pathway_Homo sapiens_hsa043701.07544896
67Neurotrophin signaling pathway_Homo sapiens_hsa047221.06437773
68beta-Alanine metabolism_Homo sapiens_hsa004101.05611106
69Histidine metabolism_Homo sapiens_hsa003401.04668957
70Maturity onset diabetes of the young_Homo sapiens_hsa049501.04663668
71Viral carcinogenesis_Homo sapiens_hsa052031.04049223
72Inositol phosphate metabolism_Homo sapiens_hsa005621.03771706
73Endometrial cancer_Homo sapiens_hsa052131.03747978
74Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01590438
75T cell receptor signaling pathway_Homo sapiens_hsa046601.01419922
76Osteoclast differentiation_Homo sapiens_hsa043800.98806833
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97794916
78One carbon pool by folate_Homo sapiens_hsa006700.97120697
79Type II diabetes mellitus_Homo sapiens_hsa049300.96228814
80Hepatitis C_Homo sapiens_hsa051600.94781150
81Fatty acid biosynthesis_Homo sapiens_hsa000610.94492512
82Prostate cancer_Homo sapiens_hsa052150.93919503
83Hematopoietic cell lineage_Homo sapiens_hsa046400.93767994
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93709186
85mRNA surveillance pathway_Homo sapiens_hsa030150.93457180
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92764503
87Pentose phosphate pathway_Homo sapiens_hsa000300.92541677
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90803202
89Prolactin signaling pathway_Homo sapiens_hsa049170.90741923
90Cell cycle_Homo sapiens_hsa041100.90078530
91p53 signaling pathway_Homo sapiens_hsa041150.89448196
92Tuberculosis_Homo sapiens_hsa051520.88599015
93Sulfur metabolism_Homo sapiens_hsa009200.88159737
94Shigellosis_Homo sapiens_hsa051310.87709286
95ErbB signaling pathway_Homo sapiens_hsa040120.86159855
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85580304
97MicroRNAs in cancer_Homo sapiens_hsa052060.84456546
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83846431
99Fatty acid elongation_Homo sapiens_hsa000620.83829384
100Insulin resistance_Homo sapiens_hsa049310.83530091
101Ribosome_Homo sapiens_hsa030100.83312383
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82359880
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81844446
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81575724
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81138176
106Apoptosis_Homo sapiens_hsa042100.79634472
107Glycerolipid metabolism_Homo sapiens_hsa005610.79306555
108Dorso-ventral axis formation_Homo sapiens_hsa043200.78788058
109Insulin secretion_Homo sapiens_hsa049110.78416771
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.77741373
111Nucleotide excision repair_Homo sapiens_hsa034200.76947716
112Starch and sucrose metabolism_Homo sapiens_hsa005000.76899738
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.76340238
114Fat digestion and absorption_Homo sapiens_hsa049750.75414399
115Pyruvate metabolism_Homo sapiens_hsa006200.75355999
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.74815977
117Steroid biosynthesis_Homo sapiens_hsa001000.72972835
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72955542
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71658511
120Phenylalanine metabolism_Homo sapiens_hsa003600.71547857
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.71119263
122Chemical carcinogenesis_Homo sapiens_hsa052040.70705756
123TNF signaling pathway_Homo sapiens_hsa046680.69813053
124Pyrimidine metabolism_Homo sapiens_hsa002400.68176403
125Prion diseases_Homo sapiens_hsa050200.67893008
126Selenocompound metabolism_Homo sapiens_hsa004500.67371687
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66552370
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65074203
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.64863735
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63308250
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62240825
132Lysosome_Homo sapiens_hsa041420.62161168
133Gastric acid secretion_Homo sapiens_hsa049710.61726861
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61360806
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60970894
136GABAergic synapse_Homo sapiens_hsa047270.59200283
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59185466
138Salivary secretion_Homo sapiens_hsa049700.58948145
139Mismatch repair_Homo sapiens_hsa034300.58276126
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.58034346
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57504579
142Tyrosine metabolism_Homo sapiens_hsa003500.57425927
143Notch signaling pathway_Homo sapiens_hsa043300.56615280
144Glutamatergic synapse_Homo sapiens_hsa047240.56591245
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.56585610
146N-Glycan biosynthesis_Homo sapiens_hsa005100.55698674
147AMPK signaling pathway_Homo sapiens_hsa041520.54341339
148Glucagon signaling pathway_Homo sapiens_hsa049220.53272284
149Carbon metabolism_Homo sapiens_hsa012000.52980510
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52898625
151Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52057207
152Retinol metabolism_Homo sapiens_hsa008300.51972854
153Renin secretion_Homo sapiens_hsa049240.51753152
154FoxO signaling pathway_Homo sapiens_hsa040680.50937510
155MAPK signaling pathway_Homo sapiens_hsa040100.50838416
156Focal adhesion_Homo sapiens_hsa045100.50767146
157Thyroid hormone synthesis_Homo sapiens_hsa049180.50335516
158Systemic lupus erythematosus_Homo sapiens_hsa053220.49946823
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49677223
160Cocaine addiction_Homo sapiens_hsa050300.49666494
161Estrogen signaling pathway_Homo sapiens_hsa049150.47781413
162Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47108900
163Circadian entrainment_Homo sapiens_hsa047130.46533427
164Vitamin digestion and absorption_Homo sapiens_hsa049770.46368560
165Insulin signaling pathway_Homo sapiens_hsa049100.46111790
166Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45211065
167Biosynthesis of amino acids_Homo sapiens_hsa012300.44070294
168mTOR signaling pathway_Homo sapiens_hsa041500.44066078
169Glycerophospholipid metabolism_Homo sapiens_hsa005640.43881046
170Long-term potentiation_Homo sapiens_hsa047200.43529748
171Phospholipase D signaling pathway_Homo sapiens_hsa040720.42988467
172Renal cell carcinoma_Homo sapiens_hsa052110.41637491
173Glioma_Homo sapiens_hsa052140.41623543
174Cholinergic synapse_Homo sapiens_hsa047250.41475454
175Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40090383
176Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39935428
177Synaptic vesicle cycle_Homo sapiens_hsa047210.37431161
178cAMP signaling pathway_Homo sapiens_hsa040240.37404845
179GnRH signaling pathway_Homo sapiens_hsa049120.37397521
180Choline metabolism in cancer_Homo sapiens_hsa052310.37061697
181Drug metabolism - other enzymes_Homo sapiens_hsa009830.36704286
182Morphine addiction_Homo sapiens_hsa050320.36083607
183Dopaminergic synapse_Homo sapiens_hsa047280.35544106
184cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34901768
185Pancreatic secretion_Homo sapiens_hsa049720.34811052

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