TGIF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.62426378
2maturation of SSU-rRNA (GO:0030490)4.40196091
3DNA topological change (GO:0006265)4.16887263
4establishment of integrated proviral latency (GO:0075713)4.07635699
5ribosomal small subunit assembly (GO:0000028)3.95203262
6paraxial mesoderm development (GO:0048339)3.94974909
7DNA ligation (GO:0006266)3.90595898
8DNA strand elongation involved in DNA replication (GO:0006271)3.85786289
9histone exchange (GO:0043486)3.80314420
10formation of translation preinitiation complex (GO:0001731)3.77181516
11DNA replication initiation (GO:0006270)3.76073271
12nuclear pore organization (GO:0006999)3.75102595
13protein localization to kinetochore (GO:0034501)3.74324098
14DNA strand elongation (GO:0022616)3.69325231
15mitotic nuclear envelope disassembly (GO:0007077)3.66182899
16mitotic metaphase plate congression (GO:0007080)3.65248954
17DNA replication-dependent nucleosome assembly (GO:0006335)3.60734577
18DNA replication-dependent nucleosome organization (GO:0034723)3.60734577
19viral transcription (GO:0019083)3.59988766
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.55521754
21DNA strand renaturation (GO:0000733)3.54752989
22translational termination (GO:0006415)3.52407102
23nucleobase biosynthetic process (GO:0046112)3.45045723
24regulation of posttranscriptional gene silencing (GO:0060147)3.44741410
25regulation of gene silencing by miRNA (GO:0060964)3.44741410
26regulation of gene silencing by RNA (GO:0060966)3.44741410
27pre-miRNA processing (GO:0031054)3.43929867
28mitotic sister chromatid cohesion (GO:0007064)3.41037301
29nuclear envelope disassembly (GO:0051081)3.40296538
30membrane disassembly (GO:0030397)3.40296538
31nuclear pore complex assembly (GO:0051292)3.39602181
32regulation of centriole replication (GO:0046599)3.37040427
33telomere maintenance via semi-conservative replication (GO:0032201)3.32488219
34translational elongation (GO:0006414)3.29153976
35metaphase plate congression (GO:0051310)3.29105838
36ribosome biogenesis (GO:0042254)3.28692289
37translational initiation (GO:0006413)3.28591429
38protein localization to chromosome, centromeric region (GO:0071459)3.26284641
39negative regulation of RNA splicing (GO:0033119)3.25867431
40folic acid-containing compound biosynthetic process (GO:0009396)3.24185016
41negative regulation of mRNA metabolic process (GO:1903312)3.24070939
42DNA replication checkpoint (GO:0000076)3.22594843
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.21018259
44regulation of mitotic spindle checkpoint (GO:1903504)3.21018259
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19383032
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.19039849
47DNA duplex unwinding (GO:0032508)3.18443757
48ribosomal large subunit biogenesis (GO:0042273)3.17796102
49ribonucleoprotein complex biogenesis (GO:0022613)3.17609286
50regulation of spindle organization (GO:0090224)3.17595152
51DNA geometric change (GO:0032392)3.15909476
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.13954388
53IMP biosynthetic process (GO:0006188)3.10009009
54negative regulation of DNA repair (GO:0045738)3.10003372
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09701283
56negative regulation of translation, ncRNA-mediated (GO:0040033)3.09701283
57regulation of translation, ncRNA-mediated (GO:0045974)3.09701283
58purine nucleobase biosynthetic process (GO:0009113)3.09646008
59ribosomal small subunit biogenesis (GO:0042274)3.09613676
60L-serine metabolic process (GO:0006563)3.08884409
61DNA replication-independent nucleosome organization (GO:0034724)3.08687539
62DNA replication-independent nucleosome assembly (GO:0006336)3.08687539
63mitotic chromosome condensation (GO:0007076)3.07768985
64establishment of viral latency (GO:0019043)3.07320846
65replication fork processing (GO:0031297)3.05676003
66IMP metabolic process (GO:0046040)3.05057454
67DNA double-strand break processing (GO:0000729)3.03269004
68chromatin remodeling at centromere (GO:0031055)3.03110113
69mitotic G2/M transition checkpoint (GO:0044818)3.02882117
70non-recombinational repair (GO:0000726)3.02340144
71double-strand break repair via nonhomologous end joining (GO:0006303)3.02340144
72negative regulation of chromosome segregation (GO:0051985)3.02078515
73spliceosomal snRNP assembly (GO:0000387)3.01998108
74negative regulation of mRNA processing (GO:0050686)3.01981898
75ribosome assembly (GO:0042255)3.01949645
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01888718
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01388173
78CENP-A containing nucleosome assembly (GO:0034080)3.01075915
79RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.99718559
80mRNA splicing, via spliceosome (GO:0000398)2.99718559
81regulation of centrosome cycle (GO:0046605)2.99456765
82RNA splicing, via transesterification reactions (GO:0000375)2.98193467
83peptidyl-arginine omega-N-methylation (GO:0035247)2.98078503
84histone H2A acetylation (GO:0043968)2.96540150
85mitotic sister chromatid segregation (GO:0000070)2.96456218
86negative regulation of mitotic sister chromatid separation (GO:2000816)2.95711728
87negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95711728
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95711728
89negative regulation of sister chromatid segregation (GO:0033046)2.95711728
90histone H2A monoubiquitination (GO:0035518)2.95508512
91mitotic spindle assembly checkpoint (GO:0007094)2.94427040
92telomere maintenance via recombination (GO:0000722)2.94272787
93kinetochore organization (GO:0051383)2.94215568
94regulation of sister chromatid segregation (GO:0033045)2.93422531
95regulation of mitotic sister chromatid separation (GO:0010965)2.93422531
96regulation of mitotic sister chromatid segregation (GO:0033047)2.93422531
97somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.92767438
98somatic cell DNA recombination (GO:0016444)2.92767438
99mitotic recombination (GO:0006312)2.92110203
100somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90517902
101somatic hypermutation of immunoglobulin genes (GO:0016446)2.90517902
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89404695
103spindle assembly checkpoint (GO:0071173)2.89281759
104heterochromatin organization (GO:0070828)2.88980396
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88773368
106regulation of sister chromatid cohesion (GO:0007063)2.88661226
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88298610
108regulation of chromosome segregation (GO:0051983)2.87400306
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87283559
110histone arginine methylation (GO:0034969)2.86770890
111mitotic spindle checkpoint (GO:0071174)2.86133938
112isotype switching (GO:0045190)2.85687809
113protein localization to chromosome (GO:0034502)2.85396910
114kinetochore assembly (GO:0051382)2.85232885
115rRNA processing (GO:0006364)2.84820422
116telomere maintenance via telomere lengthening (GO:0010833)2.83640907
117sister chromatid segregation (GO:0000819)2.83452215
118negative regulation of histone methylation (GO:0031061)2.82860111
119spindle checkpoint (GO:0031577)2.82633867
120establishment of chromosome localization (GO:0051303)2.82066210
121DNA deamination (GO:0045006)2.81941504
122positive regulation of chromosome segregation (GO:0051984)2.81007187
123regulation of histone H3-K9 methylation (GO:0051570)2.79933532
124protein complex localization (GO:0031503)2.79481836
125translesion synthesis (GO:0019985)2.79042940
126termination of RNA polymerase II transcription (GO:0006369)2.77621680
127rRNA metabolic process (GO:0016072)2.77593281
128chromatin assembly or disassembly (GO:0006333)2.77117904
129regulation of helicase activity (GO:0051095)2.74883862
130cellular protein complex disassembly (GO:0043624)2.74562708
131nuclear-transcribed mRNA catabolic process (GO:0000956)2.73041007
132regulation of mitotic metaphase/anaphase transition (GO:0030071)2.72968920
133ATP-dependent chromatin remodeling (GO:0043044)2.72959575
134viral life cycle (GO:0019058)2.72713834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.37777769
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.38871098
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.29946826
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48224070
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34889918
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30421171
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17032033
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09848766
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75400454
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56152423
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.42997384
12XRN2_22483619_ChIP-Seq_HELA_Human2.39796049
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32634356
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.31504421
15MYC_22102868_ChIP-Seq_BL_Human2.29959235
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.29123014
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23758867
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.21025215
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14109146
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04334669
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.02388914
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01830646
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98642645
24AR_21909140_ChIP-Seq_LNCAP_Human1.98322273
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93993214
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93390568
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91233582
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.88657439
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85039954
30CIITA_25753668_ChIP-Seq_RAJI_Human1.81777796
31VDR_23849224_ChIP-Seq_CD4+_Human1.80698357
32TTF2_22483619_ChIP-Seq_HELA_Human1.78651077
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76003273
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75960869
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75710985
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.67530753
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65042912
38* GABP_19822575_ChIP-Seq_HepG2_Human1.64364211
39FOXP3_21729870_ChIP-Seq_TREG_Human1.62827634
40* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62062752
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61379350
42DCP1A_22483619_ChIP-Seq_HELA_Human1.60832605
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55382091
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54120627
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53392480
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52661446
47* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50354933
48* SOX2_16153702_ChIP-ChIP_HESCs_Human1.50045045
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50043352
50MYC_18940864_ChIP-ChIP_HL60_Human1.49903670
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47790913
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46350317
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45555683
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45555683
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45555683
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44006784
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43517466
58KDM5A_27292631_Chip-Seq_BREAST_Human1.42938655
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.40453634
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38857155
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34698365
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34366285
63* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33866159
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.33297100
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33126935
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32052730
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31584967
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28931515
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28432590
70VDR_21846776_ChIP-Seq_THP-1_Human1.27591673
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26497548
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26471891
73ZNF274_21170338_ChIP-Seq_K562_Hela1.21447808
74ELK1_19687146_ChIP-ChIP_HELA_Human1.19919614
75* NANOG_21062744_ChIP-ChIP_HESCs_Human1.19464706
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.19180449
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18758961
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18706570
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16030891
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15950089
81EWS_26573619_Chip-Seq_HEK293_Human1.15184584
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14898934
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.13387591
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12785678
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12720159
86IRF1_19129219_ChIP-ChIP_H3396_Human1.12456204
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11902052
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11376260
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10731312
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09761656
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08767693
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07137611
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06213870
94* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05715761
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05226496
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05100398
97* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02749793
98TFEB_21752829_ChIP-Seq_HELA_Human1.01810171
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00260550
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98988651
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98184594
102SALL1_21062744_ChIP-ChIP_HESCs_Human0.97703728
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96924878
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96792086
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96192531
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95509666
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94513165
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94088442
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93609248
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92172981
111* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90960194
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.90548752
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90304826
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89226442
115* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88795066
116TCF7_22412390_ChIP-Seq_EML_Mouse0.86026041
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83192899
118* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78926100
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.78398044
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75805373
121FUS_26573619_Chip-Seq_HEK293_Human0.73267953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.90695034
2MP0010094_abnormal_chromosome_stability3.64990480
3MP0003111_abnormal_nucleus_morphology3.57409980
4MP0004957_abnormal_blastocyst_morpholog3.54096666
5MP0003077_abnormal_cell_cycle3.39963442
6MP0008057_abnormal_DNA_replication3.14447692
7MP0008058_abnormal_DNA_repair2.72561556
8MP0003123_paternal_imprinting2.59078689
9MP0010030_abnormal_orbit_morphology2.54706433
10MP0008007_abnormal_cellular_replicative2.53260839
11MP0008877_abnormal_DNA_methylation2.29131172
12MP0001730_embryonic_growth_arrest2.12753413
13MP0008932_abnormal_embryonic_tissue2.11991953
14MP0002653_abnormal_ependyma_morphology2.08279949
15MP0000350_abnormal_cell_proliferation2.07543910
16MP0002254_reproductive_system_inflammat2.05267700
17MP0000537_abnormal_urethra_morphology2.04473526
18MP0010352_gastrointestinal_tract_polyps2.04273300
19MP0002396_abnormal_hematopoietic_system1.99704264
20MP0003136_yellow_coat_color1.91791867
21MP0002084_abnormal_developmental_patter1.79766091
22MP0005380_embryogenesis_phenotype1.79122207
23MP0001672_abnormal_embryogenesis/_devel1.79122207
24MP0002085_abnormal_embryonic_tissue1.78063399
25MP0009278_abnormal_bone_marrow1.77400008
26MP0003315_abnormal_perineum_morphology1.75890624
27MP0005076_abnormal_cell_differentiation1.73387465
28MP0001697_abnormal_embryo_size1.72443056
29MP0000566_synostosis1.69505653
30MP0001293_anophthalmia1.69358861
31MP0009053_abnormal_anal_canal1.67842830
32MP0003984_embryonic_growth_retardation1.63898943
33MP0004197_abnormal_fetal_growth/weight/1.63810943
34MP0000372_irregular_coat_pigmentation1.63254838
35MP0003121_genomic_imprinting1.62225270
36MP0002088_abnormal_embryonic_growth/wei1.62223251
37MP0004808_abnormal_hematopoietic_stem1.61283541
38MP0003786_premature_aging1.59044567
39MP0003567_abnormal_fetal_cardiomyocyte1.57730531
40MP0002086_abnormal_extraembryonic_tissu1.50144016
41MP0003119_abnormal_digestive_system1.50071953
42MP0009697_abnormal_copulation1.48983271
43MP0000490_abnormal_crypts_of1.48130286
44MP0002080_prenatal_lethality1.47299251
45MP0003943_abnormal_hepatobiliary_system1.45064531
46MP0003890_abnormal_embryonic-extraembry1.42468659
47MP0003941_abnormal_skin_development1.42374135
48MP0004133_heterotaxia1.35216530
49MP0001346_abnormal_lacrimal_gland1.32705606
50MP0010307_abnormal_tumor_latency1.25515957
51MP0002249_abnormal_larynx_morphology1.25096286
52MP0002210_abnormal_sex_determination1.24334959
53MP0000049_abnormal_middle_ear1.23736099
54MP0002938_white_spotting1.23383738
55MP0000428_abnormal_craniofacial_morphol1.22496854
56MP0003937_abnormal_limbs/digits/tail_de1.21746304
57MP0005084_abnormal_gallbladder_morpholo1.20947180
58MP0000313_abnormal_cell_death1.20854423
59MP0003705_abnormal_hypodermis_morpholog1.18740171
60MP0003283_abnormal_digestive_organ1.17241788
61MP0005397_hematopoietic_system_phenotyp1.14929318
62MP0001545_abnormal_hematopoietic_system1.14929318
63MP0002019_abnormal_tumor_incidence1.12873034
64MP0002932_abnormal_joint_morphology1.08886823
65MP0002111_abnormal_tail_morphology1.08643252
66MP0002751_abnormal_autonomic_nervous1.07590011
67MP0006035_abnormal_mitochondrial_morpho1.07024579
68MP0002282_abnormal_trachea_morphology1.06885703
69MP0002277_abnormal_respiratory_mucosa1.06748397
70MP0001145_abnormal_male_reproductive1.05099153
71MP0003942_abnormal_urinary_system1.04017524
72MP0002092_abnormal_eye_morphology1.04017013
73MP0000703_abnormal_thymus_morphology1.02852000
74MP0005075_abnormal_melanosome_morpholog1.00455028
75MP0003763_abnormal_thymus_physiology0.99538541
76MP0003115_abnormal_respiratory_system0.98892535
77MP0003935_abnormal_craniofacial_develop0.97352893
78MP0008995_early_reproductive_senescence0.97346342
79MP0006292_abnormal_olfactory_placode0.96161601
80MP0005394_taste/olfaction_phenotype0.95705221
81MP0005499_abnormal_olfactory_system0.95705221
82MP0001849_ear_inflammation0.95228965
83MP0000733_abnormal_muscle_development0.94191805
84MP0002697_abnormal_eye_size0.93811126
85MP0000432_abnormal_head_morphology0.90609587
86MP0000653_abnormal_sex_gland0.89458568
87MP0001286_abnormal_eye_development0.89418949
88MP0001929_abnormal_gametogenesis0.88409166
89MP0006054_spinal_hemorrhage0.87808702
90MP0001915_intracranial_hemorrhage0.87610895
91MP0002163_abnormal_gland_morphology0.87176697
92MP0003755_abnormal_palate_morphology0.86202926
93MP0003878_abnormal_ear_physiology0.84690610
94MP0005377_hearing/vestibular/ear_phenot0.84690610
95MP0002102_abnormal_ear_morphology0.83584974
96MP0001119_abnormal_female_reproductive0.83546667
97MP0003938_abnormal_ear_development0.83304409
98MP0002233_abnormal_nose_morphology0.82836652
99MP0003718_maternal_effect0.82484163
100MP0003861_abnormal_nervous_system0.82193978
101MP0002116_abnormal_craniofacial_bone0.80973461
102MP0006072_abnormal_retinal_apoptosis0.80199994
103MP0003385_abnormal_body_wall0.79859275
104MP0003186_abnormal_redox_activity0.79104239
105MP0009672_abnormal_birth_weight0.76397734
106MP0002114_abnormal_axial_skeleton0.75746372
107MP0002138_abnormal_hepatobiliary_system0.75024714
108MP0009333_abnormal_splenocyte_physiolog0.74337113
109MP0002925_abnormal_cardiovascular_devel0.74334792
110MP0005187_abnormal_penis_morphology0.73668815
111MP0005023_abnormal_wound_healing0.72792792
112MP0002089_abnormal_postnatal_growth/wei0.72243813
113MP0000631_abnormal_neuroendocrine_gland0.71919292
114MP0004264_abnormal_extraembryonic_tissu0.70944987
115MP0002398_abnormal_bone_marrow0.70931082
116MP0003122_maternal_imprinting0.70858970
117MP0003195_calcinosis0.70352874
118MP0002722_abnormal_immune_system0.70098439
119MP0005391_vision/eye_phenotype0.69752522
120MP0001529_abnormal_vocalization0.69239201
121MP0002160_abnormal_reproductive_system0.68521674
122MP0009703_decreased_birth_body0.68402796
123MP0008789_abnormal_olfactory_epithelium0.68362769
124MP0000358_abnormal_cell_content/0.67551303
125MP0001324_abnormal_eye_pigmentation0.66643281
126MP0001177_atelectasis0.66625647
127MP0000534_abnormal_ureter_morphology0.65931940
128MP0005408_hypopigmentation0.65728286
129MP0000477_abnormal_intestine_morphology0.64447932

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.79591150
2Selective tooth agenesis (HP:0001592)3.65928270
3Medulloblastoma (HP:0002885)3.40839877
4Birth length less than 3rd percentile (HP:0003561)3.27942337
5Reticulocytopenia (HP:0001896)3.21712458
6Ependymoma (HP:0002888)3.10925441
7Patellar aplasia (HP:0006443)3.09601082
8Nephroblastoma (Wilms tumor) (HP:0002667)2.97339646
9Aplasia/Hypoplasia of the patella (HP:0006498)2.94272401
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91701243
11Short 4th metacarpal (HP:0010044)2.91701243
12Breast hypoplasia (HP:0003187)2.91528318
13Abnormal number of incisors (HP:0011064)2.82958500
14Embryonal renal neoplasm (HP:0011794)2.80643301
15Abnormality of cells of the erythroid lineage (HP:0012130)2.75043608
16Bilateral microphthalmos (HP:0007633)2.64797197
17Horseshoe kidney (HP:0000085)2.58803025
18Septo-optic dysplasia (HP:0100842)2.57287299
19Degeneration of anterior horn cells (HP:0002398)2.57264054
20Abnormality of the anterior horn cell (HP:0006802)2.57264054
21Abnormal number of erythroid precursors (HP:0012131)2.50660760
22Microvesicular hepatic steatosis (HP:0001414)2.48841358
23Increased nuchal translucency (HP:0010880)2.47909596
24Rib fusion (HP:0000902)2.43896849
25Atresia of the external auditory canal (HP:0000413)2.42743525
26Renal duplication (HP:0000075)2.40565472
27Neoplasm of the pancreas (HP:0002894)2.37340300
28Neoplasm of the oral cavity (HP:0100649)2.36711295
29Oral leukoplakia (HP:0002745)2.36191836
30Rhabdomyosarcoma (HP:0002859)2.35563352
31Sloping forehead (HP:0000340)2.35545143
32Missing ribs (HP:0000921)2.34788395
33Chromsome breakage (HP:0040012)2.33312933
34Proximal placement of thumb (HP:0009623)2.32732112
35Basal cell carcinoma (HP:0002671)2.29329734
36Meckel diverticulum (HP:0002245)2.28333495
3711 pairs of ribs (HP:0000878)2.28324230
38Abdominal situs inversus (HP:0003363)2.28256151
39Abnormality of abdominal situs (HP:0011620)2.28256151
40Pancreatic islet-cell hyperplasia (HP:0004510)2.27102026
41Abnormality of the ileum (HP:0001549)2.26908709
42Supernumerary spleens (HP:0009799)2.26234915
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26184690
44Abnormality of the 4th metacarpal (HP:0010012)2.24458821
45Deviation of the thumb (HP:0009603)2.23430368
46Abnormal lung lobation (HP:0002101)2.23138162
47Facial hemangioma (HP:0000329)2.20432473
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.20190934
49Hypoplastic pelvis (HP:0008839)2.19402560
50Absent radius (HP:0003974)2.18611111
51Rectovaginal fistula (HP:0000143)2.17973486
52Rectal fistula (HP:0100590)2.17973486
53Aplasia/Hypoplasia of the sternum (HP:0006714)2.16950272
54Rectal prolapse (HP:0002035)2.14567165
55Clubbing of toes (HP:0100760)2.13272847
56Multiple enchondromatosis (HP:0005701)2.11284117
57Neoplasm of striated muscle (HP:0009728)2.11082984
58Intestinal atresia (HP:0011100)2.10919006
59Ectopic kidney (HP:0000086)2.09334988
60Overlapping toe (HP:0001845)2.09126978
61Volvulus (HP:0002580)2.08602154
62Anal stenosis (HP:0002025)2.07452851
63Myelodysplasia (HP:0002863)2.07075825
64Aplasia involving forearm bones (HP:0009822)2.06920884
65Absent forearm bone (HP:0003953)2.06920884
66Abnormality of the astrocytes (HP:0100707)2.06630012
67Astrocytoma (HP:0009592)2.06630012
68Small intestinal stenosis (HP:0012848)2.06267334
69Duodenal stenosis (HP:0100867)2.06267334
70Carpal bone hypoplasia (HP:0001498)2.06079508
71Absent thumb (HP:0009777)2.04542580
72Anophthalmia (HP:0000528)2.04084189
73Abnormality of the labia minora (HP:0012880)2.03728577
74Hyperglycinemia (HP:0002154)2.02635917
75Abnormality of chromosome stability (HP:0003220)2.00928998
76Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99628727
77Esophageal atresia (HP:0002032)1.97450780
78Agnosia (HP:0010524)1.96815681
79Glioma (HP:0009733)1.96699111
80Tracheoesophageal fistula (HP:0002575)1.96095710
81Irregular epiphyses (HP:0010582)1.95774127
82Pendular nystagmus (HP:0012043)1.94728449
83High anterior hairline (HP:0009890)1.94137770
84Macrocytic anemia (HP:0001972)1.94064963
85Neoplasm of the adrenal cortex (HP:0100641)1.93745980
86Hyperglycinuria (HP:0003108)1.93089367
87Microretrognathia (HP:0000308)1.92281209
88Short 5th finger (HP:0009237)1.91475582
89Aplastic anemia (HP:0001915)1.91010885
90Trismus (HP:0000211)1.90461928
91Aqueductal stenosis (HP:0002410)1.88929020
92Supernumerary bones of the axial skeleton (HP:0009144)1.88810538
93Trigonocephaly (HP:0000243)1.88499014
94Shawl scrotum (HP:0000049)1.87919358
95Abnormality of the fingertips (HP:0001211)1.87846700
96Abnormality of the preputium (HP:0100587)1.87610652
97Malignant gastrointestinal tract tumors (HP:0006749)1.87449350
98Gastrointestinal carcinoma (HP:0002672)1.87449350
99Stenosis of the external auditory canal (HP:0000402)1.86851372
100Broad palm (HP:0001169)1.86535246
101Pallor (HP:0000980)1.86484125
102Hemivertebrae (HP:0002937)1.85748381
103Short middle phalanx of the 5th finger (HP:0004220)1.85103776
104Intestinal fistula (HP:0100819)1.84924996
105Abnormality of the duodenum (HP:0002246)1.84559975
106Neoplasm of the colon (HP:0100273)1.84492052
107Hyperacusis (HP:0010780)1.83863135
108Supernumerary ribs (HP:0005815)1.83490625
109Gastrointestinal atresia (HP:0002589)1.83479258
110Oligodactyly (HP:0012165)1.82487240
111Vaginal fistula (HP:0004320)1.82006081
112Short thumb (HP:0009778)1.81935165
113Long eyelashes (HP:0000527)1.81214583
114Skull defect (HP:0001362)1.80930494
115Preaxial hand polydactyly (HP:0001177)1.79886291
116Bifid tongue (HP:0010297)1.79419195
117Abnormality of the septum pellucidum (HP:0007375)1.79341380
118Skin tags (HP:0010609)1.78836199
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78689960
120Embryonal neoplasm (HP:0002898)1.78225585
121Absent septum pellucidum (HP:0001331)1.77324698
122Choanal atresia (HP:0000453)1.77054777
123Preauricular skin tag (HP:0000384)1.76984523
124Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.76138951
125Abnormality of DNA repair (HP:0003254)1.75908798
126Abnormality of the carotid arteries (HP:0005344)1.74750004
127Cleft eyelid (HP:0000625)1.74327610
128Duplicated collecting system (HP:0000081)1.74280550
129Biliary tract neoplasm (HP:0100574)1.74265051
130Pelvic girdle muscle weakness (HP:0003749)1.74057170
131Broad thumb (HP:0011304)1.73995301
132Absent epiphyses (HP:0010577)1.73368865
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73368865
134High pitched voice (HP:0001620)1.72592711
135Triphalangeal thumb (HP:0001199)1.72284091
136Abnormal sex determination (HP:0012244)1.71618252
137Sex reversal (HP:0012245)1.71618252
138Rough bone trabeculation (HP:0100670)1.71591265
139Abnormality of the parathyroid morphology (HP:0011766)1.71462247
140Abnormality of glycine metabolism (HP:0010895)1.70570763
141Abnormality of serine family amino acid metabolism (HP:0010894)1.70570763
142Dandy-Walker malformation (HP:0001305)1.69943115
143Duplication of thumb phalanx (HP:0009942)1.69721826
144Hepatoblastoma (HP:0002884)1.69370435
145Acute lymphatic leukemia (HP:0006721)1.69359820
146Oligodactyly (hands) (HP:0001180)1.68908685
147Abnormality of methionine metabolism (HP:0010901)1.68562749
148Spastic diplegia (HP:0001264)1.68461745
149Abnormality of homocysteine metabolism (HP:0010919)1.65576441
150Homocystinuria (HP:0002156)1.65576441
151Cellular immunodeficiency (HP:0005374)1.65480541
152Impulsivity (HP:0100710)1.65313724
153Hypoplasia of the pons (HP:0012110)1.63857409
154Gonadotropin excess (HP:0000837)1.63153992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.77552679
2VRK23.53453955
3BUB13.45140447
4WEE13.41258832
5CDK122.89413034
6NEK22.83692440
7EEF2K2.68704824
8TAF12.67797481
9NUAK12.65062103
10TSSK62.53950095
11MKNK12.52022195
12ACVR1B2.32774205
13MAP3K102.31497793
14TTK2.26832856
15PBK2.26368408
16SRPK12.12758892
17CDK71.98498560
18MKNK21.98286970
19TGFBR11.92833173
20PASK1.88140037
21RPS6KB21.83602025
22BRD41.82356225
23DYRK31.82292615
24PLK41.80070175
25PLK11.80053444
26SMG11.79864106
27EIF2AK11.78731304
28TRIM281.77349097
29ATR1.64210185
30PAK41.61870273
31CDK41.57729726
32RPS6KA41.56002374
33PKN21.48895316
34AURKB1.46779525
35NEK11.41805436
36STK31.41292301
37STK101.37801950
38PNCK1.36327761
39TRIB31.33745273
40MST41.31676549
41BMPR1B1.31363986
42CHEK21.31091288
43MAP3K81.28256796
44TNIK1.27551889
45PLK31.26273114
46CHEK11.23861885
47TLK11.22279265
48WNK31.18866038
49EPHB21.17526138
50LATS21.12063582
51ICK1.11656930
52MELK1.11581948
53BRSK21.10904602
54CDK191.08834110
55EIF2AK21.07144878
56NME21.05128811
57MAP2K31.01055985
58AURKA0.99349386
59LATS10.98510450
60EPHA20.97434016
61CDK80.97053113
62TESK20.95299011
63PIM10.95156035
64MTOR0.95061474
65NME10.94173209
66VRK10.91729647
67BRSK10.90573018
68CDK20.89070410
69ATM0.88225022
70FGFR20.88058968
71CDK60.86658104
72BCKDK0.84715230
73EIF2AK30.81460170
74ALK0.79791658
75LRRK20.79270246
76FLT30.78205014
77MAP4K10.77204163
78KSR10.73386305
79PAK20.72204450
80MAP4K20.71207852
81STK40.70172222
82FGFR10.66610325
83STK240.66253222
84CDK10.65486540
85NLK0.65464663
86CHUK0.64994756
87STK38L0.64970809
88MAP3K30.61876378
89STK160.61781183
90RPS6KA10.61506627
91PAK10.57932929
92RPS6KA50.57192052
93TYRO30.55801930
94CSNK2A20.54400172
95AKT20.52689316
96CDK90.50966424
97PTK60.50164554
98YES10.49191639
99CSNK1G10.48982038
100CSNK2A10.48768636
101CDK30.45909867
102ILK0.45201319
103PDGFRA0.44016887
104BCR0.43555051
105FGFR40.42257125
106KIT0.41592610
107PIM20.41477051
108MAP2K20.39643839
109CSNK1E0.39358567
110CLK10.38935916
111SCYL20.38739749
112BTK0.37944405
113MAP3K110.37942953
114MAPK110.37492162
115SIK30.36791119
116MARK30.36738819
117FGR0.36693191
118TAOK20.36614133
119PRKCI0.35482977
120DYRK20.34539285
121AKT10.34459640
122KDR0.33091756
123PDK20.32958758
124MATK0.31583532
125PRKDC0.31530206
126MAPKAPK20.31270290
127ZAK0.29789628
128DAPK10.29656398
129OXSR10.21618425
130ERBB40.20423362
131RPS6KB10.19989153
132IRAK20.19625168
133GSK3B0.18215327
134LMTK20.18010699
135MAPK140.16765173

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30669669
2Mismatch repair_Homo sapiens_hsa034303.75832721
3Spliceosome_Homo sapiens_hsa030403.51076722
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38245862
5RNA transport_Homo sapiens_hsa030133.12034662
6Ribosome_Homo sapiens_hsa030103.10727436
7Cell cycle_Homo sapiens_hsa041102.95718865
8Base excision repair_Homo sapiens_hsa034102.88964748
9RNA polymerase_Homo sapiens_hsa030202.81363948
10Nucleotide excision repair_Homo sapiens_hsa034202.56365486
11Homologous recombination_Homo sapiens_hsa034402.55119149
12One carbon pool by folate_Homo sapiens_hsa006702.39585743
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23625904
14Proteasome_Homo sapiens_hsa030502.07170033
15Fanconi anemia pathway_Homo sapiens_hsa034602.06491230
16mRNA surveillance pathway_Homo sapiens_hsa030152.06007316
17RNA degradation_Homo sapiens_hsa030181.94224612
18Pyrimidine metabolism_Homo sapiens_hsa002401.90966924
19Basal transcription factors_Homo sapiens_hsa030221.81547272
20Non-homologous end-joining_Homo sapiens_hsa034501.74680824
21p53 signaling pathway_Homo sapiens_hsa041151.70936411
22Notch signaling pathway_Homo sapiens_hsa043301.59629278
23Basal cell carcinoma_Homo sapiens_hsa052171.56610707
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41663318
25Steroid biosynthesis_Homo sapiens_hsa001001.39763473
26Protein export_Homo sapiens_hsa030601.39261181
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37876595
28Propanoate metabolism_Homo sapiens_hsa006401.35357465
29Epstein-Barr virus infection_Homo sapiens_hsa051691.32237456
30Hippo signaling pathway_Homo sapiens_hsa043901.29718795
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29279861
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23368349
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20858513
34Herpes simplex infection_Homo sapiens_hsa051681.17322635
35HTLV-I infection_Homo sapiens_hsa051661.16959924
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15597197
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14393349
38MicroRNAs in cancer_Homo sapiens_hsa052061.14061956
39Hedgehog signaling pathway_Homo sapiens_hsa043401.11918904
40Small cell lung cancer_Homo sapiens_hsa052221.11143740
41Viral carcinogenesis_Homo sapiens_hsa052031.08246235
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07002078
43Colorectal cancer_Homo sapiens_hsa052101.03741197
44Oocyte meiosis_Homo sapiens_hsa041141.02341471
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02286814
46Thyroid cancer_Homo sapiens_hsa052161.00425970
47Chronic myeloid leukemia_Homo sapiens_hsa052200.99552137
48Pyruvate metabolism_Homo sapiens_hsa006200.94653281
49Purine metabolism_Homo sapiens_hsa002300.92906957
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92859311
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89118256
52Carbon metabolism_Homo sapiens_hsa012000.88554387
53Systemic lupus erythematosus_Homo sapiens_hsa053220.85736141
54* TGF-beta signaling pathway_Homo sapiens_hsa043500.84582889
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83418121
56Antigen processing and presentation_Homo sapiens_hsa046120.81560434
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79450695
58Selenocompound metabolism_Homo sapiens_hsa004500.77467325
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72384664
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71602641
61Vitamin digestion and absorption_Homo sapiens_hsa049770.71399474
62Wnt signaling pathway_Homo sapiens_hsa043100.70740105
63Vitamin B6 metabolism_Homo sapiens_hsa007500.69908161
64Pathways in cancer_Homo sapiens_hsa052000.69385140
65Legionellosis_Homo sapiens_hsa051340.67850165
66Adherens junction_Homo sapiens_hsa045200.67524784
67Hepatitis B_Homo sapiens_hsa051610.67523166
68Bladder cancer_Homo sapiens_hsa052190.66030423
69Fatty acid elongation_Homo sapiens_hsa000620.64115792
70Biosynthesis of amino acids_Homo sapiens_hsa012300.63959113
71Acute myeloid leukemia_Homo sapiens_hsa052210.63767214
72mTOR signaling pathway_Homo sapiens_hsa041500.63228411
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.58985418
74Huntingtons disease_Homo sapiens_hsa050160.57742280
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.56800636
76Apoptosis_Homo sapiens_hsa042100.55546836
77Folate biosynthesis_Homo sapiens_hsa007900.55127053
78Parkinsons disease_Homo sapiens_hsa050120.54539337
79Endometrial cancer_Homo sapiens_hsa052130.53800870
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53250708
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52726114
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52672666
83Measles_Homo sapiens_hsa051620.51948374
84Lysine degradation_Homo sapiens_hsa003100.50275725
85Viral myocarditis_Homo sapiens_hsa054160.50215537
86Sulfur relay system_Homo sapiens_hsa041220.49928782
87Non-small cell lung cancer_Homo sapiens_hsa052230.49704661
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49363277
89Shigellosis_Homo sapiens_hsa051310.48217883
90Proteoglycans in cancer_Homo sapiens_hsa052050.47318593
91Glutathione metabolism_Homo sapiens_hsa004800.47089001
92Pancreatic cancer_Homo sapiens_hsa052120.46350100
93Pentose phosphate pathway_Homo sapiens_hsa000300.46329924
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.45769022
95Prostate cancer_Homo sapiens_hsa052150.43449748
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43425924
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.42985162
98Metabolic pathways_Homo sapiens_hsa011000.41068874
99Peroxisome_Homo sapiens_hsa041460.40279967
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39900794
101HIF-1 signaling pathway_Homo sapiens_hsa040660.39863986
102Fatty acid metabolism_Homo sapiens_hsa012120.39544660
103Primary immunodeficiency_Homo sapiens_hsa053400.38278098
104T cell receptor signaling pathway_Homo sapiens_hsa046600.37900570
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.37861710
106Influenza A_Homo sapiens_hsa051640.37098944
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37088466
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36825966
109FoxO signaling pathway_Homo sapiens_hsa040680.34187051
110Tight junction_Homo sapiens_hsa045300.33317928
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33134948
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.32782476
113Melanoma_Homo sapiens_hsa052180.32040900
114Fatty acid degradation_Homo sapiens_hsa000710.30933873
115Butanoate metabolism_Homo sapiens_hsa006500.30441078
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29097862
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29096862
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.28985484
119Alcoholism_Homo sapiens_hsa050340.27829271
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27742300
121Toxoplasmosis_Homo sapiens_hsa051450.25850829
122Oxidative phosphorylation_Homo sapiens_hsa001900.24526570
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.24305576
124Prolactin signaling pathway_Homo sapiens_hsa049170.24281125
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23976604
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22810448
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21607032
128Renal cell carcinoma_Homo sapiens_hsa052110.20165241
129N-Glycan biosynthesis_Homo sapiens_hsa005100.19190049
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18696352
131B cell receptor signaling pathway_Homo sapiens_hsa046620.17803334
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17297051
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.17161138
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17152123
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.16956369
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16320531
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15178048
138Tryptophan metabolism_Homo sapiens_hsa003800.10606027
139Asthma_Homo sapiens_hsa053100.07697556

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