TGIF2-C20ORF24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring TGIF2 (TGFB-induced factor homeobox 2) and C20orf24 (chromosome 20 open reading frame 24) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.66462623
2ribosomal large subunit biogenesis (GO:0042273)4.57656249
3ribosomal small subunit biogenesis (GO:0042274)4.52829164
4nuclear pore organization (GO:0006999)4.01599082
5ribosomal small subunit assembly (GO:0000028)3.97251453
6ribonucleoprotein complex biogenesis (GO:0022613)3.91254120
7formation of translation preinitiation complex (GO:0001731)3.89292091
8proteasome assembly (GO:0043248)3.78724374
9maturation of SSU-rRNA (GO:0030490)3.78312736
10rRNA modification (GO:0000154)3.74622828
11DNA unwinding involved in DNA replication (GO:0006268)3.63229037
12pore complex assembly (GO:0046931)3.60014794
13ribosome biogenesis (GO:0042254)3.54423421
14ribosome assembly (GO:0042255)3.53942495
15viral transcription (GO:0019083)3.51368537
16DNA strand elongation involved in DNA replication (GO:0006271)3.50258784
17DNA strand elongation (GO:0022616)3.47698650
18negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.46488753
19mitotic chromosome condensation (GO:0007076)3.44457563
20translational termination (GO:0006415)3.43696987
21folic acid-containing compound biosynthetic process (GO:0009396)3.38732010
22IMP biosynthetic process (GO:0006188)3.36555367
23regulation of mitochondrial translation (GO:0070129)3.32508221
24establishment of integrated proviral latency (GO:0075713)3.29822336
25purine nucleobase biosynthetic process (GO:0009113)3.27708407
26translational initiation (GO:0006413)3.24341967
27mitotic nuclear envelope disassembly (GO:0007077)3.24103579
28rRNA processing (GO:0006364)3.23538344
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20989310
30regulation of RNA export from nucleus (GO:0046831)3.16327579
31translational elongation (GO:0006414)3.13792629
32telomere maintenance via semi-conservative replication (GO:0032201)3.12776011
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10818330
34rRNA metabolic process (GO:0016072)3.10406542
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09147539
36regulation of translational fidelity (GO:0006450)3.08233753
37rRNA methylation (GO:0031167)3.05570426
38positive regulation of protein homooligomerization (GO:0032464)3.04682565
39regulation of retinoic acid receptor signaling pathway (GO:0048385)3.02983925
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02218021
41IMP metabolic process (GO:0046040)3.01560737
42mitotic metaphase plate congression (GO:0007080)3.00620007
43membrane disassembly (GO:0030397)2.99469434
44nuclear envelope disassembly (GO:0051081)2.99469434
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98091495
46nucleobase biosynthetic process (GO:0046112)2.97581787
47cotranslational protein targeting to membrane (GO:0006613)2.97303484
48protein targeting to ER (GO:0045047)2.96265328
49translation (GO:0006412)2.95673438
50transcription elongation from RNA polymerase III promoter (GO:0006385)2.94386393
51termination of RNA polymerase III transcription (GO:0006386)2.94386393
52positive regulation of cell cycle checkpoint (GO:1901978)2.91045482
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87993111
54establishment of viral latency (GO:0019043)2.86476584
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86050064
56establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85466570
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85228319
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82772914
59telomere maintenance via recombination (GO:0000722)2.82013972
60negative regulation of RNA splicing (GO:0033119)2.81845141
61rRNA transcription (GO:0009303)2.81392917
62spliceosomal snRNP assembly (GO:0000387)2.80034327
63regulation of sister chromatid cohesion (GO:0007063)2.79688912
64transcription from mitochondrial promoter (GO:0006390)2.78621807
65mitotic sister chromatid segregation (GO:0000070)2.77672337
66heterochromatin organization (GO:0070828)2.76713117
67regulation of translational termination (GO:0006449)2.76628700
68viral life cycle (GO:0019058)2.75881759
69DNA replication initiation (GO:0006270)2.75603511
70pinocytosis (GO:0006907)2.74718072
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73988248
72negative regulation of ligase activity (GO:0051352)2.73988248
73regulation of nucleobase-containing compound transport (GO:0032239)2.72676099
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72069390
75regulation of mitotic spindle checkpoint (GO:1903504)2.72069390
76protein localization to endoplasmic reticulum (GO:0070972)2.70559935
77cellular protein complex disassembly (GO:0043624)2.68431778
78mitotic recombination (GO:0006312)2.66754055
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65362480
80protein localization to chromosome, centromeric region (GO:0071459)2.64391210
81cellular component biogenesis (GO:0044085)2.61957761
82protein targeting to mitochondrion (GO:0006626)2.61632372
83maturation of 5.8S rRNA (GO:0000460)2.60207903
84mitochondrial fusion (GO:0008053)2.59390626
85activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.59114467
86regulation of spindle checkpoint (GO:0090231)2.57771925
87protein maturation by protein folding (GO:0022417)2.56444547
88antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.56440359
89B cell mediated immunity (GO:0019724)2.55145037
90nuclear-transcribed mRNA catabolic process (GO:0000956)2.52689240
91nucleobase-containing small molecule interconversion (GO:0015949)2.51434028
92regulation of translation in response to stress (GO:0043555)2.50867086
93sister chromatid segregation (GO:0000819)2.50469020
94negative regulation of mRNA processing (GO:0050686)2.49999252
95regulation of transcription from RNA polymerase I promoter (GO:0006356)2.47958725
96somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.47841367
97somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.47841367
98isotype switching (GO:0045190)2.47841367
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.46804214
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.46804214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.25979487
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89375128
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48292649
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28243986
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12160373
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.11943908
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.65249026
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61963920
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59857100
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59276643
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58745326
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55232410
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54400869
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54334958
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.46491544
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.44970079
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.43626834
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39137348
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27127288
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.24798169
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14941883
22DCP1A_22483619_ChIP-Seq_HELA_Human2.04720031
23XRN2_22483619_ChIP-Seq_HELA_Human2.04444810
24MYC_22102868_ChIP-Seq_BL_Human2.04036567
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97728505
26FOXP3_21729870_ChIP-Seq_TREG_Human1.94541959
27VDR_23849224_ChIP-Seq_CD4+_Human1.91919548
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83305083
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82270039
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78706190
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75660403
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75659003
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74937072
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.72130753
35TTF2_22483619_ChIP-Seq_HELA_Human1.71699146
36GABP_19822575_ChIP-Seq_HepG2_Human1.71395742
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70927314
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70507165
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.69985661
40AR_21909140_ChIP-Seq_LNCAP_Human1.69498657
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62923604
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62118632
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61711620
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61388671
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58093802
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57061236
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56296049
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55059290
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54190749
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53237666
51ELK1_19687146_ChIP-ChIP_HELA_Human1.48185096
52ZNF263_19887448_ChIP-Seq_K562_Human1.47528723
53CIITA_25753668_ChIP-Seq_RAJI_Human1.45918359
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42637019
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42443106
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42203634
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39818496
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37419245
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.37046408
60SPI1_23547873_ChIP-Seq_NB4_Human1.35767651
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34895635
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34209416
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33615892
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33083748
65KDM5A_27292631_Chip-Seq_BREAST_Human1.31753595
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27572045
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27524543
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25897718
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25010465
70TFEB_21752829_ChIP-Seq_HELA_Human1.23297253
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.21873464
72VDR_21846776_ChIP-Seq_THP-1_Human1.20058287
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15417497
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13726899
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13093097
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11994132
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11350352
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10165379
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08863564
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07165311
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06043167
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05163792
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05023623
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04795975
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04046143
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99714406
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99685564
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97283546
89MYB_26560356_Chip-Seq_TH2_Human0.96730586
90MAF_26560356_Chip-Seq_TH1_Human0.93555638
91STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91663200
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91514003
93IRF8_21731497_ChIP-ChIP_J774_Mouse0.89666084
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89326938
95MYB_26560356_Chip-Seq_TH1_Human0.88297900
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85583400
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84448324
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.84318711
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84306990
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.83311298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.71055115
2MP0001835_abnormal_antigen_presentation3.46678059
3MP0004957_abnormal_blastocyst_morpholog3.37130592
4MP0010094_abnormal_chromosome_stability3.27025396
5MP0005451_abnormal_body_composition3.25262166
6MP0003111_abnormal_nucleus_morphology3.24246640
7MP0008057_abnormal_DNA_replication3.06741648
8MP0003077_abnormal_cell_cycle2.87482547
9MP0008007_abnormal_cellular_replicative2.63512584
10MP0009333_abnormal_splenocyte_physiolog2.47650944
11MP0000685_abnormal_immune_system2.26613528
12MP0008058_abnormal_DNA_repair2.19658262
13MP0008260_abnormal_autophagy2.14513035
14MP0004233_abnormal_muscle_weight2.06047689
15MP0008932_abnormal_embryonic_tissue2.03249967
16MP0000350_abnormal_cell_proliferation1.86425820
17MP0004808_abnormal_hematopoietic_stem1.84943820
18MP0002396_abnormal_hematopoietic_system1.83610915
19MP0001730_embryonic_growth_arrest1.78892070
20MP0000490_abnormal_crypts_of1.68048606
21MP0003806_abnormal_nucleotide_metabolis1.67457060
22MP0009697_abnormal_copulation1.65067586
23MP0003191_abnormal_cellular_cholesterol1.59898720
24MP0002166_altered_tumor_susceptibility1.58741926
25MP0005408_hypopigmentation1.51407402
26MP0000313_abnormal_cell_death1.49848084
27MP0003436_decreased_susceptibility_to1.47955434
28MP0005380_embryogenesis_phenotype1.46333995
29MP0001672_abnormal_embryogenesis/_devel1.46333995
30MP0000858_altered_metastatic_potential1.45171466
31MP0003984_embryonic_growth_retardation1.44325602
32MP0002398_abnormal_bone_marrow1.44084647
33MP0001853_heart_inflammation1.43562542
34MP0001697_abnormal_embryo_size1.42910438
35MP0001800_abnormal_humoral_immune1.42046845
36MP0003786_premature_aging1.39110411
37MP0002080_prenatal_lethality1.35736366
38MP0005000_abnormal_immune_tolerance1.35387146
39MP0002088_abnormal_embryonic_growth/wei1.32264001
40MP0002019_abnormal_tumor_incidence1.32075715
41MP0010352_gastrointestinal_tract_polyps1.31696440
42MP0002452_abnormal_antigen_presenting1.29529731
43MP0002006_tumorigenesis1.28981604
44MP0003718_maternal_effect1.27305082
45MP0002877_abnormal_melanocyte_morpholog1.26980208
46MP0001915_intracranial_hemorrhage1.26208051
47MP0002722_abnormal_immune_system1.25335865
48MP0002723_abnormal_immune_serum1.22341195
49MP0003943_abnormal_hepatobiliary_system1.20856344
50MP0000703_abnormal_thymus_morphology1.19372828
51MP0002420_abnormal_adaptive_immunity1.18145850
52MP0001819_abnormal_immune_cell1.17757749
53MP0006035_abnormal_mitochondrial_morpho1.17693751
54MP0002429_abnormal_blood_cell1.17295899
55MP0000689_abnormal_spleen_morphology1.16227530
56MP0003221_abnormal_cardiomyocyte_apopto1.15400472
57MP0009785_altered_susceptibility_to1.15385046
58MP0005464_abnormal_platelet_physiology1.15102487
59MP0002086_abnormal_extraembryonic_tissu1.12724213
60MP0009672_abnormal_birth_weight1.10825312
61MP0000716_abnormal_immune_system1.10020003
62MP0002132_abnormal_respiratory_system1.10009801
63MP0002148_abnormal_hypersensitivity_rea1.07031346
64MP0004264_abnormal_extraembryonic_tissu1.05486140
65MP0000358_abnormal_cell_content/1.05046727
66MP0002419_abnormal_innate_immunity1.03707533
67MP0005025_abnormal_response_to1.01692458
68MP0008995_early_reproductive_senescence1.00668282
69MP0001881_abnormal_mammary_gland0.99022716
70MP0005671_abnormal_response_to0.97942224
71MP0003315_abnormal_perineum_morphology0.97776306
72MP0004185_abnormal_adipocyte_glucose0.97378321
73MP0009278_abnormal_bone_marrow0.96465583
74MP0001849_ear_inflammation0.95332705
75MP0008877_abnormal_DNA_methylation0.95269149
76MP0001790_abnormal_immune_system0.91120818
77MP0005387_immune_system_phenotype0.91120818
78MP0005397_hematopoietic_system_phenotyp0.90098562
79MP0001545_abnormal_hematopoietic_system0.90098562
80MP0005621_abnormal_cell_physiology0.89858267
81MP0005384_cellular_phenotype0.89817153
82MP0002405_respiratory_system_inflammati0.89685621
83MP0003763_abnormal_thymus_physiology0.89585653
84MP0009764_decreased_sensitivity_to0.87869600
85MP0002085_abnormal_embryonic_tissue0.86840853
86MP0003300_gastrointestinal_ulcer0.85251002
87MP0000609_abnormal_liver_physiology0.83988759
88MP0000627_abnormal_mammary_gland0.82227558
89MP0010155_abnormal_intestine_physiology0.81859739
90MP0003566_abnormal_cell_adhesion0.81053988
91MP0005076_abnormal_cell_differentiation0.79487582
92MP0010307_abnormal_tumor_latency0.79102417
93MP0003329_amyloid_beta_deposits0.76081105
94MP0003705_abnormal_hypodermis_morpholog0.75191155
95MP0000604_amyloidosis0.72044339
96MP0006036_abnormal_mitochondrial_physio0.69285034
97MP0001346_abnormal_lacrimal_gland0.68220191
98MP0008469_abnormal_protein_level0.68041324
99MP0000598_abnormal_liver_morphology0.66942551
100MP0002796_impaired_skin_barrier0.66552469

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.67894849
2Microvesicular hepatic steatosis (HP:0001414)4.24040300
3Increased IgM level (HP:0003496)4.18416101
4Multiple enchondromatosis (HP:0005701)4.14508865
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.56289426
6Trismus (HP:0000211)3.28153800
7IgA deficiency (HP:0002720)3.04796109
8Chromsome breakage (HP:0040012)3.04760144
9Oral leukoplakia (HP:0002745)2.97230366
10Rough bone trabeculation (HP:0100670)2.95216247
11Reticulocytopenia (HP:0001896)2.86376067
12Cleft eyelid (HP:0000625)2.79047950
13Aplastic anemia (HP:0001915)2.78150167
14Respiratory difficulties (HP:0002880)2.69948619
15Abnormality of T cell physiology (HP:0011840)2.69702707
16Upper motor neuron abnormality (HP:0002127)2.67080323
17Abnormality of cells of the erythroid lineage (HP:0012130)2.65357765
18Progressive muscle weakness (HP:0003323)2.47800509
19Abnormality of the preputium (HP:0100587)2.45565593
20Progressive external ophthalmoplegia (HP:0000590)2.38470813
21Glossoptosis (HP:0000162)2.36366260
22Facial cleft (HP:0002006)2.34850837
23Abnormality of glycolysis (HP:0004366)2.34500901
24Increased hepatocellular lipid droplets (HP:0006565)2.33887494
25Abnormal trabecular bone morphology (HP:0100671)2.30889299
26Abnormal number of erythroid precursors (HP:0012131)2.28959516
27Nephroblastoma (Wilms tumor) (HP:0002667)2.28907330
28Deep venous thrombosis (HP:0002625)2.28621109
29Syringomyelia (HP:0003396)2.26763937
30Spinal cord lesions (HP:0100561)2.26763937
31Meckel diverticulum (HP:0002245)2.25278414
32Increased serum pyruvate (HP:0003542)2.23357935
33Lipid accumulation in hepatocytes (HP:0006561)2.22008611
34Autoimmune hemolytic anemia (HP:0001890)2.20767313
35Pallor (HP:0000980)2.19825915
36Myelodysplasia (HP:0002863)2.19602544
37Micronodular cirrhosis (HP:0001413)2.13846495
38Thrombocytosis (HP:0001894)2.11864927
39Subacute progressive viral hepatitis (HP:0006572)2.10868790
40Macrocytic anemia (HP:0001972)2.08892699
41Microglossia (HP:0000171)2.08762769
42Viral hepatitis (HP:0006562)2.07228764
43Gingivitis (HP:0000230)2.06489960
44Embryonal renal neoplasm (HP:0011794)2.05155848
45IgG deficiency (HP:0004315)2.04447854
46Aplasia/Hypoplasia of the thymus (HP:0010515)2.02913086
47Nasolacrimal duct obstruction (HP:0000579)2.02580335
48Abnormality of the ileum (HP:0001549)2.01264529
49Fatigue (HP:0012378)2.00412024
50Overlapping toe (HP:0001845)1.96330817
51Recurrent viral infections (HP:0004429)1.96127565
52Orthostatic hypotension (HP:0001278)1.95659961
53Hepatitis (HP:0012115)1.93551554
54Premature ovarian failure (HP:0008209)1.93335174
55Preauricular skin tag (HP:0000384)1.89908037
56Cellular immunodeficiency (HP:0005374)1.89469273
57Granulocytopenia (HP:0001913)1.86909002
58B lymphocytopenia (HP:0010976)1.83364741
59Agammaglobulinemia (HP:0004432)1.82980041
60Hypergonadotropic hypogonadism (HP:0000815)1.82810645
61Birth length less than 3rd percentile (HP:0003561)1.82797567
62Deviation of the thumb (HP:0009603)1.77601890
63Patent foramen ovale (HP:0001655)1.74509189
64Abnormality of the lower motor neuron (HP:0002366)1.74041977
65Abnormality of placental membranes (HP:0011409)1.73940289
66Amniotic constriction ring (HP:0009775)1.73940289
67Abnormality of T cells (HP:0002843)1.73619253
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73028141
69Proximal placement of thumb (HP:0009623)1.72526280
70Somatic mutation (HP:0001428)1.70764212
71Bone marrow hypocellularity (HP:0005528)1.70379743
72Hypobetalipoproteinemia (HP:0003563)1.69417504
73Selective tooth agenesis (HP:0001592)1.68956584
74Dysphonia (HP:0001618)1.68320405
75Abnormality of the lacrimal duct (HP:0011481)1.65803155
76Abnormality of the alveolar ridges (HP:0006477)1.65799345
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.62705826
78Poikiloderma (HP:0001029)1.62496083
79Low anterior hairline (HP:0000294)1.61375802
80Type I transferrin isoform profile (HP:0003642)1.60218333
81Exertional dyspnea (HP:0002875)1.59790564
82Uterine leiomyosarcoma (HP:0002891)1.59185512
83Leiomyosarcoma (HP:0100243)1.59185512
84Abnormal lung lobation (HP:0002101)1.58806334
85Testicular atrophy (HP:0000029)1.58473428
86Hypergammaglobulinemia (HP:0010702)1.58441648
87Pseudobulbar signs (HP:0002200)1.58201141
88Abnormality of the thymus (HP:0000777)1.57436348
89Impaired proprioception (HP:0010831)1.57325297
90Abnormality of the umbilical cord (HP:0010881)1.56806149
91Progressive hearing impairment (HP:0001730)1.56679787
92Abnormality of the peritoneum (HP:0002585)1.56619608
93Abnormality of B cell number (HP:0010975)1.54897892
94Deep philtrum (HP:0002002)1.54837490
95Colitis (HP:0002583)1.53268582
96Increased intramyocellular lipid droplets (HP:0012240)1.53206414
97Prolonged partial thromboplastin time (HP:0003645)1.51625853
98Capillary hemangiomas (HP:0005306)1.51455855
99Choanal atresia (HP:0000453)1.51323786
100Reduced antithrombin III activity (HP:0001976)1.50178607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.44268439
2VRK23.39910562
3SCYL23.14463902
4SMG13.02184656
5BUB13.00169578
6CDC72.56169654
7SRPK12.55162707
8PRPF4B2.45808709
9STK162.33504720
10PBK2.31916066
11CDK122.28127538
12EIF2AK12.07094904
13IRAK31.97627670
14BMPR21.95094764
15TESK21.94233221
16ZAK1.88670408
17EEF2K1.82187928
18TAOK21.69654843
19RPS6KB21.65950781
20CDK71.58239331
21PAK41.57386800
22EIF2AK31.54146432
23MAP3K141.48888447
24RIPK41.47946382
25CDK191.46505203
26FGFR41.37761566
27TTK1.36717257
28FLT31.35665546
29VRK11.34819147
30NME11.33383510
31BRSK21.29665020
32MAP3K131.25431142
33ICK1.18374342
34TRIB31.10917271
35TSSK61.08561046
36CHEK21.08487614
37EIF2AK21.07917536
38TAF11.05822670
39KSR21.04585078
40PASK1.02381498
41PLK31.02070326
42AURKB1.01536597
43CDK40.99125613
44NEK10.97913371
45ATR0.95790112
46MAPK110.94262832
47ALK0.91186641
48NUAK10.87475251
49MAP3K80.86373808
50CHEK10.85500860
51CSF1R0.84208874
52STK100.83308959
53PKN20.82202698
54MAP4K10.82025627
55MAP3K120.77742075
56TLK10.76613860
57BRSK10.74644447
58LRRK20.74175355
59IKBKE0.73046363
60RAF10.72731481
61FGFR30.72715349
62PLK10.68869745
63BCKDK0.67314024
64CLK10.65973909
65AURKA0.65960369
66KDR0.65394386
67IKBKB0.62446900
68RPS6KA40.61569647
69PLK40.61487885
70LATS20.61436227
71STK40.60962049
72ERN10.56570086
73MAP3K10.53732085
74FGFR10.53203954
75CDK80.51538928
76BMX0.51243746
77MAP2K30.48975240
78IRAK40.48890737
79LATS10.48583663
80PIM10.44805819
81MAP3K100.44655673
82CDK60.42653085
83TBK10.42060422
84CSNK2A20.41370315
85ERBB40.40718034
86RPS6KA10.40338986
87JAK30.40083518
88MARK30.39856106
89NEK90.39671101
90ATM0.38145410
91BRD40.37992836
92EPHA20.36701057
93MTOR0.35967737
94RPS6KA50.35846430
95MOS0.35727500
96SIK10.35696439
97CDK90.35361181
98TYK20.35175069
99TESK10.34323829
100CDK10.33275953

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.77302205
2Ribosome_Homo sapiens_hsa030103.76100517
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52336523
4Proteasome_Homo sapiens_hsa030503.42781607
5RNA polymerase_Homo sapiens_hsa030202.82274853
6Spliceosome_Homo sapiens_hsa030402.65157021
7Asthma_Homo sapiens_hsa053102.63004600
8Mismatch repair_Homo sapiens_hsa034302.56186970
9RNA transport_Homo sapiens_hsa030132.55206339
10One carbon pool by folate_Homo sapiens_hsa006702.17574369
11Allograft rejection_Homo sapiens_hsa053302.10707328
12Autoimmune thyroid disease_Homo sapiens_hsa053201.98517670
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96319926
14Base excision repair_Homo sapiens_hsa034101.90823883
15Nucleotide excision repair_Homo sapiens_hsa034201.76219813
16Cell cycle_Homo sapiens_hsa041101.75928351
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73823922
18Viral myocarditis_Homo sapiens_hsa054161.68498633
19mRNA surveillance pathway_Homo sapiens_hsa030151.67786908
20Pyrimidine metabolism_Homo sapiens_hsa002401.65147870
21Systemic lupus erythematosus_Homo sapiens_hsa053221.47823447
22Epstein-Barr virus infection_Homo sapiens_hsa051691.45768234
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.45438172
24Primary immunodeficiency_Homo sapiens_hsa053401.44913013
25Vitamin B6 metabolism_Homo sapiens_hsa007501.39477283
26Leishmaniasis_Homo sapiens_hsa051401.38942119
27Non-homologous end-joining_Homo sapiens_hsa034501.37927211
28RNA degradation_Homo sapiens_hsa030181.34457558
29Herpes simplex infection_Homo sapiens_hsa051681.25843571
30Graft-versus-host disease_Homo sapiens_hsa053321.22654708
31Homologous recombination_Homo sapiens_hsa034401.16723696
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.15830749
33Viral carcinogenesis_Homo sapiens_hsa052031.09583198
34Bladder cancer_Homo sapiens_hsa052191.09175642
35Thyroid cancer_Homo sapiens_hsa052161.08814303
36Type I diabetes mellitus_Homo sapiens_hsa049401.02100549
37Influenza A_Homo sapiens_hsa051641.01314896
38Antigen processing and presentation_Homo sapiens_hsa046120.97884731
39Toxoplasmosis_Homo sapiens_hsa051450.95070556
40Acute myeloid leukemia_Homo sapiens_hsa052210.88623315
41p53 signaling pathway_Homo sapiens_hsa041150.88352541
42Measles_Homo sapiens_hsa051620.87391036
43Legionellosis_Homo sapiens_hsa051340.87046098
44Purine metabolism_Homo sapiens_hsa002300.86183215
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85449224
46B cell receptor signaling pathway_Homo sapiens_hsa046620.82912514
47Fanconi anemia pathway_Homo sapiens_hsa034600.81500093
48Apoptosis_Homo sapiens_hsa042100.81055419
49Basal transcription factors_Homo sapiens_hsa030220.80132337
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.80127364
51Pentose phosphate pathway_Homo sapiens_hsa000300.79776238
52Hepatitis B_Homo sapiens_hsa051610.79238125
53Protein export_Homo sapiens_hsa030600.78713337
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76540421
55Shigellosis_Homo sapiens_hsa051310.75586051
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75304362
57Small cell lung cancer_Homo sapiens_hsa052220.75064769
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73201464
59Chronic myeloid leukemia_Homo sapiens_hsa052200.72447326
60Carbon metabolism_Homo sapiens_hsa012000.72332100
61Non-small cell lung cancer_Homo sapiens_hsa052230.70815119
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70309707
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69183934
64Pancreatic cancer_Homo sapiens_hsa052120.68573696
65Staphylococcus aureus infection_Homo sapiens_hsa051500.64974774
66HTLV-I infection_Homo sapiens_hsa051660.64846698
67Biosynthesis of amino acids_Homo sapiens_hsa012300.62187725
68Folate biosynthesis_Homo sapiens_hsa007900.61362936
69Huntingtons disease_Homo sapiens_hsa050160.60745310
70TNF signaling pathway_Homo sapiens_hsa046680.59048034
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56889578
72Rheumatoid arthritis_Homo sapiens_hsa053230.56132319
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.55960420
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53265143
75Tuberculosis_Homo sapiens_hsa051520.51885052
76Parkinsons disease_Homo sapiens_hsa050120.50751191
77N-Glycan biosynthesis_Homo sapiens_hsa005100.50702549
78T cell receptor signaling pathway_Homo sapiens_hsa046600.49707715
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48213228
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46805071
81Colorectal cancer_Homo sapiens_hsa052100.46740148
82Regulation of autophagy_Homo sapiens_hsa041400.45666151
83Prostate cancer_Homo sapiens_hsa052150.45115759
84Oxidative phosphorylation_Homo sapiens_hsa001900.44985581
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43649218
86MicroRNAs in cancer_Homo sapiens_hsa052060.43118478
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39603283
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39334196
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37249777
90HIF-1 signaling pathway_Homo sapiens_hsa040660.34812110
91Glutathione metabolism_Homo sapiens_hsa004800.34550971
92Oocyte meiosis_Homo sapiens_hsa041140.34316630
93Renal cell carcinoma_Homo sapiens_hsa052110.33967140
94Selenocompound metabolism_Homo sapiens_hsa004500.33383878
95Endometrial cancer_Homo sapiens_hsa052130.32683086
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31991921
97Hematopoietic cell lineage_Homo sapiens_hsa046400.31156766
98Osteoclast differentiation_Homo sapiens_hsa043800.29541135
99Fructose and mannose metabolism_Homo sapiens_hsa000510.27622837
100Alcoholism_Homo sapiens_hsa050340.27084755

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »