TGIF2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide biosynthetic process (GO:0009312)9.64677101
2meiotic chromosome segregation (GO:0045132)8.23925011
3cellular response to ATP (GO:0071318)6.44612894
4DNA strand renaturation (GO:0000733)6.32213290
5mitotic sister chromatid segregation (GO:0000070)5.57608035
6regulation of cytokine production involved in inflammatory response (GO:1900015)5.26663572
7negative regulation of cell aging (GO:0090344)5.25891561
8regulation of hippo signaling (GO:0035330)5.24239226
9DNA double-strand break processing (GO:0000729)5.18993010
10nucleotide transmembrane transport (GO:1901679)4.76061058
11interferon-gamma production (GO:0032609)4.75547176
12rRNA methylation (GO:0031167)4.73424555
13sister chromatid segregation (GO:0000819)4.72625660
14negative regulation of smooth muscle cell differentiation (GO:0051151)4.58098069
15retinal cone cell development (GO:0046549)4.47822438
16behavioral response to nicotine (GO:0035095)4.47629304
17purinergic nucleotide receptor signaling pathway (GO:0035590)4.29082694
18misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.25953318
19negative regulation of autophagy (GO:0010507)4.12459957
20keratinocyte development (GO:0003334)4.11651507
21sensory perception of taste (GO:0050909)4.08779250
22detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.06441965
23adenosine receptor signaling pathway (GO:0001973)4.04391177
24sex determination (GO:0007530)4.03466310
25reciprocal meiotic recombination (GO:0007131)4.00765150
26reciprocal DNA recombination (GO:0035825)4.00765150
27rRNA modification (GO:0000154)3.96599593
28lens fiber cell differentiation (GO:0070306)3.91972459
29detection of light stimulus involved in visual perception (GO:0050908)3.89017764
30detection of light stimulus involved in sensory perception (GO:0050962)3.89017764
31nucleoside transmembrane transport (GO:1901642)3.84023927
32piRNA metabolic process (GO:0034587)3.83308693
33urinary tract smooth muscle contraction (GO:0014848)3.81375166
34respiratory tube development (GO:0030323)3.79302693
35tyrosine metabolic process (GO:0006570)3.76477284
36multicellular organism reproduction (GO:0032504)3.74020676
37purine ribonucleotide transport (GO:0015868)3.69739626
38regulation of skeletal muscle contraction (GO:0014819)3.65517579
39histone H3-K4 trimethylation (GO:0080182)3.62271877
40peristalsis (GO:0030432)3.60066291
41embryonic body morphogenesis (GO:0010172)3.56019389
42mannosylation (GO:0097502)3.54667398
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.53554748
44L-phenylalanine catabolic process (GO:0006559)3.53554748
45regulation of posttranscriptional gene silencing (GO:0060147)3.51778391
46regulation of gene silencing by miRNA (GO:0060964)3.51778391
47regulation of gene silencing by RNA (GO:0060966)3.51778391
48adenine nucleotide transport (GO:0051503)3.51576608
49positive regulation of fatty acid beta-oxidation (GO:0032000)3.48928102
50positive regulation of fatty acid oxidation (GO:0046321)3.43167296
51response to misfolded protein (GO:0051788)3.36321865
52positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.36164278
53protein import into peroxisome matrix (GO:0016558)3.35258867
54oligosaccharide metabolic process (GO:0009311)3.34796157
55neuromuscular synaptic transmission (GO:0007274)3.33794321
56dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.32554716
57eye photoreceptor cell development (GO:0042462)3.32342868
58protein K11-linked deubiquitination (GO:0035871)3.29132002
59folic acid transport (GO:0015884)3.26924344
60peptidyl-lysine methylation (GO:0018022)3.24865822
61G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.23046997
62photoreceptor cell development (GO:0042461)3.22959191
63response to ATP (GO:0033198)3.19268529
64negative regulation of viral entry into host cell (GO:0046597)3.19050620
65negative regulation of histone methylation (GO:0031061)3.18889881
66positive regulation of protein kinase C signaling (GO:0090037)3.17979755
67melanin biosynthetic process (GO:0042438)3.13547369
68DNA replication initiation (GO:0006270)3.10645521
69transepithelial transport (GO:0070633)3.10541977
70histone H2B ubiquitination (GO:0033523)3.10405949
71folic acid metabolic process (GO:0046655)3.07156798
72sialylation (GO:0097503)3.06510931
73peptidyl-lysine trimethylation (GO:0018023)3.05132357
74DNA integration (GO:0015074)3.00970660
75pericardium development (GO:0060039)3.00855037
76L-phenylalanine metabolic process (GO:0006558)3.00844733
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00844733
78purinergic receptor signaling pathway (GO:0035587)2.99586958
79negative regulation of translation, ncRNA-mediated (GO:0040033)2.94906424
80regulation of translation, ncRNA-mediated (GO:0045974)2.94906424
81negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.94906424
82regulation of histone H3-K4 methylation (GO:0051569)2.91645434
83detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.90641389
84sulfate transport (GO:0008272)2.89730461
85aromatic amino acid family catabolic process (GO:0009074)2.89599166
86cardiolipin metabolic process (GO:0032048)2.80146413
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.80045385
88polarized epithelial cell differentiation (GO:0030859)2.77775226
89mitotic cell cycle arrest (GO:0071850)2.75346646
90regulation of acrosome reaction (GO:0060046)2.74985053
91secondary metabolite biosynthetic process (GO:0044550)2.74607221
92estrogen biosynthetic process (GO:0006703)2.74448055
93peroxisome fission (GO:0016559)2.73800241
94melanin metabolic process (GO:0006582)2.73299612
95phasic smooth muscle contraction (GO:0014821)2.73230018
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72979299
97meiotic cell cycle (GO:0051321)2.69102834
98water-soluble vitamin biosynthetic process (GO:0042364)2.66772189
99cytochrome complex assembly (GO:0017004)2.65527340
100protein carboxylation (GO:0018214)2.64906273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human7.26018560
2AR_21572438_ChIP-Seq_LNCaP_Human3.07251229
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.02978557
4VDR_21846776_ChIP-Seq_THP-1_Human2.93735147
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.69209169
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.55501509
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.42657091
8RXRA_24833708_ChIP-Seq_LIVER_Mouse2.27053694
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20252472
10P68_20966046_ChIP-Seq_HELA_Human2.18174628
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.12481733
12E2F1_20622854_ChIP-Seq_HELA_Human2.07782579
13MAF_26560356_Chip-Seq_TH2_Human1.96048614
14IGF1R_20145208_ChIP-Seq_DFB_Human1.93849414
15ERA_21632823_ChIP-Seq_H3396_Human1.92867981
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.91970613
17MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.91883359
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.91119489
19BCOR_27268052_Chip-Seq_Bcells_Human1.90269536
20PHF8_20622854_ChIP-Seq_HELA_Human1.85215614
21CTCF_27219007_Chip-Seq_Bcells_Human1.80552827
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79487359
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.77949981
24VDR_24763502_ChIP-Seq_THP-1_Human1.76186457
25RARA_24833708_ChIP-Seq_LIVER_Mouse1.76097231
26SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.75860280
27BCL6_27268052_Chip-Seq_Bcells_Human1.75286545
28RARB_24833708_ChIP-Seq_LIVER_Mouse1.75146147
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67502249
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.59299966
31CTCF_21964334_Chip-Seq_Bcells_Human1.58451608
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55940158
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55890865
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53093539
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.49579091
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.49327819
37CTCF_20526341_ChIP-Seq_ESCs_Human1.47767050
38OCT4_19829295_ChIP-Seq_ESCs_Human1.46877214
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.46694893
40SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45263586
41XRN2_22483619_ChIP-Seq_HELA_Human1.43943037
42KDM5A_27292631_Chip-Seq_BREAST_Human1.41533278
43TAF2_19829295_ChIP-Seq_ESCs_Human1.41026275
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38894214
45NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.38280439
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.38201752
47MYC_19829295_ChIP-Seq_ESCs_Human1.35471751
48PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34472697
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34429539
50LXR_22292898_ChIP-Seq_THP-1_Human1.34023236
51EWS_26573619_Chip-Seq_HEK293_Human1.32946781
52NANOG_20526341_ChIP-Seq_ESCs_Human1.32336208
53SA1_27219007_Chip-Seq_Bcells_Human1.31625535
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25808557
55FOXP1_21924763_ChIP-Seq_HESCs_Human1.25181993
56OCT4_20526341_ChIP-Seq_ESCs_Human1.24305176
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23804139
58ZNF274_21170338_ChIP-Seq_K562_Hela1.23599984
59TP53_22573176_ChIP-Seq_HFKS_Human1.23202377
60TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22917374
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22724256
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22408465
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22162611
64BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.20727612
65NCOR_22424771_ChIP-Seq_293T_Human1.18390679
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17637718
67CIITA_25753668_ChIP-Seq_RAJI_Human1.15262816
68FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15014083
69P53_21459846_ChIP-Seq_SAOS-2_Human1.14387007
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.13763297
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12332647
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12314319
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11899092
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.07490230
75CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06649329
76RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06151489
77P300_27268052_Chip-Seq_Bcells_Human1.05496223
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04727165
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04490670
80SMC4_20622854_ChIP-Seq_HELA_Human1.02812025
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02524285
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.01843612
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.01573987
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.01402113
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01012643
86ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00845508
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.00133533
88TP63_22573176_ChIP-Seq_HFKS_Human0.99007624
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98705407
90FOXM1_23109430_ChIP-Seq_U2OS_Human0.95998145
91RACK7_27058665_Chip-Seq_MCF-7_Human0.94950923
92MAF_26560356_Chip-Seq_TH1_Human0.94753374
93VDR_23849224_ChIP-Seq_CD4+_Human0.90661355
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89530067
95SOX2_21211035_ChIP-Seq_LN229_Human0.88938952
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88787284
97SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86923778
98UTX_26944678_Chip-Seq_JUKART_Human0.86657121
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85648870
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.85584975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.59285265
2MP0003136_yellow_coat_color6.14890404
3MP0005174_abnormal_tail_pigmentation5.85401632
4MP0001986_abnormal_taste_sensitivity5.59832310
5MP0005423_abnormal_somatic_nervous4.41344005
6MP0008057_abnormal_DNA_replication3.87382400
7MP0000015_abnormal_ear_pigmentation3.42840560
8MP0000569_abnormal_digit_pigmentation3.22826847
9MP0002653_abnormal_ependyma_morphology2.93877701
10MP0003950_abnormal_plasma_membrane2.58703505
11MP0001968_abnormal_touch/_nociception2.39199865
12MP0002638_abnormal_pupillary_reflex2.35263534
13MP0002837_dystrophic_cardiac_calcinosis2.33708482
14MP0004381_abnormal_hair_follicle2.09664735
15MP0003693_abnormal_embryo_hatching2.05612386
16MP0001188_hyperpigmentation1.89359376
17MP0002160_abnormal_reproductive_system1.86863730
18MP0008961_abnormal_basal_metabolism1.86657176
19MP0005551_abnormal_eye_electrophysiolog1.82330245
20MP0008875_abnormal_xenobiotic_pharmacok1.79547031
21MP0005410_abnormal_fertilization1.78027229
22MP0008007_abnormal_cellular_replicative1.69983196
23MP0001756_abnormal_urination1.69456798
24MP0002095_abnormal_skin_pigmentation1.64010348
25MP0004019_abnormal_vitamin_homeostasis1.62184142
26MP0005409_darkened_coat_color1.61338607
27MP0000371_diluted_coat_color1.61142388
28MP0002736_abnormal_nociception_after1.58678589
29MP0004233_abnormal_muscle_weight1.51591564
30MP0001502_abnormal_circadian_rhythm1.42523369
31MP0010094_abnormal_chromosome_stability1.39982305
32MP0004130_abnormal_muscle_cell1.37585873
33MP0005670_abnormal_white_adipose1.34398812
34MP0004043_abnormal_pH_regulation1.32357366
35MP0003943_abnormal_hepatobiliary_system1.29909283
36MP0010386_abnormal_urinary_bladder1.26934923
37MP0005365_abnormal_bile_salt1.15306383
38MP0000538_abnormal_urinary_bladder1.12382211
39MP0001664_abnormal_digestion1.11403274
40MP0003646_muscle_fatigue1.10320738
41MP0005083_abnormal_biliary_tract1.09629585
42MP0000427_abnormal_hair_cycle1.07556653
43MP0002735_abnormal_chemical_nociception1.01470818
44MP0002210_abnormal_sex_determination0.99777502
45MP0010307_abnormal_tumor_latency0.94208893
46MP0003172_abnormal_lysosome_physiology0.92124655
47MP0005253_abnormal_eye_physiology0.91342284
48MP0009278_abnormal_bone_marrow0.90844148
49MP0001929_abnormal_gametogenesis0.89631780
50MP0002277_abnormal_respiratory_mucosa0.89367821
51MP0002938_white_spotting0.86961491
52MP0005332_abnormal_amino_acid0.86819124
53MP0003698_abnormal_male_reproductive0.86733331
54MP0002075_abnormal_coat/hair_pigmentati0.86456814
55MP0001486_abnormal_startle_reflex0.86051747
56MP0000778_abnormal_nervous_system0.85840981
57MP0000358_abnormal_cell_content/0.85244879
58MP0003959_abnormal_lean_body0.83239086
59MP0005389_reproductive_system_phenotype0.82541653
60MP0009053_abnormal_anal_canal0.81951629
61MP0003077_abnormal_cell_cycle0.80738249
62MP0001970_abnormal_pain_threshold0.80729614
63MP0000470_abnormal_stomach_morphology0.79729071
64MP0003011_delayed_dark_adaptation0.77801179
65MP0001145_abnormal_male_reproductive0.76242204
66MP0001958_emphysema0.72295733
67MP0000653_abnormal_sex_gland0.72244695
68MP0005408_hypopigmentation0.70410300
69MP0001346_abnormal_lacrimal_gland0.63533892
70MP0004808_abnormal_hematopoietic_stem0.62216339
71MP0000367_abnormal_coat/_hair0.61848262
72MP0000534_abnormal_ureter_morphology0.61137031
73MP0001501_abnormal_sleep_pattern0.59457794
74MP0005386_behavior/neurological_phenoty0.59125690
75MP0004924_abnormal_behavior0.59125690
76MP0003111_abnormal_nucleus_morphology0.58520841
77MP0001186_pigmentation_phenotype0.56551524
78MP0004133_heterotaxia0.54189841
79MP0001919_abnormal_reproductive_system0.53503170
80MP0003718_maternal_effect0.52668485
81MP0001765_abnormal_ion_homeostasis0.52200649
82MP0001324_abnormal_eye_pigmentation0.51774180
83MP0009643_abnormal_urine_homeostasis0.45638881
84MP0000750_abnormal_muscle_regeneration0.44740659
85MP0005075_abnormal_melanosome_morpholog0.41868975
86MP0001119_abnormal_female_reproductive0.41424297
87MP0005595_abnormal_vascular_smooth0.40985852
88MP0005076_abnormal_cell_differentiation0.40526926
89MP0003195_calcinosis0.40247170
90MP0005167_abnormal_blood-brain_barrier0.40124833
91MP0003137_abnormal_impulse_conducting0.39444516
92MP0009250_abnormal_appendicular_skeleto0.37823700
93MP0002136_abnormal_kidney_physiology0.37666724
94MP0004134_abnormal_chest_morphology0.37352172
95MP0002161_abnormal_fertility/fecundity0.37198844
96MP0001191_abnormal_skin_condition0.35067902
97MP0002009_preneoplasia0.34790607
98MP0003638_abnormal_response/metabolism_0.32717504
99MP0008770_decreased_survivor_rate0.30061704
100MP0001293_anophthalmia0.29331961

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)5.56170485
2Pendular nystagmus (HP:0012043)5.50905981
3Attenuation of retinal blood vessels (HP:0007843)5.22981233
4Turricephaly (HP:0000262)4.77420943
5Rib fusion (HP:0000902)4.44608781
6Congenital stationary night blindness (HP:0007642)4.15589377
7Facial hemangioma (HP:0000329)4.06439605
8Testicular atrophy (HP:0000029)4.02101092
9Rectovaginal fistula (HP:0000143)4.01540168
10Rectal fistula (HP:0100590)4.01540168
11Birth length less than 3rd percentile (HP:0003561)4.00552209
12Poikiloderma (HP:0001029)3.87625734
13Popliteal pterygium (HP:0009756)3.72803405
14Intestinal fistula (HP:0100819)3.68573761
15Patellar aplasia (HP:0006443)3.59430452
16Capillary hemangiomas (HP:0005306)3.55749515
17Annular pancreas (HP:0001734)3.49304169
18Vaginal fistula (HP:0004320)3.47153673
19Myotonia (HP:0002486)3.38307386
20Coronal craniosynostosis (HP:0004440)3.37539907
21Bony spicule pigmentary retinopathy (HP:0007737)3.35349087
22Aplasia/Hypoplasia of the patella (HP:0006498)3.32012671
23Depressed nasal tip (HP:0000437)3.28146118
24Chorioretinal atrophy (HP:0000533)3.26725745
25Hypophosphatemic rickets (HP:0004912)3.22279531
26Horizontal nystagmus (HP:0000666)3.17558370
27Decreased central vision (HP:0007663)3.08162246
28Absent thumb (HP:0009777)3.00883941
29Mesangial abnormality (HP:0001966)2.87706168
30Abnormal protein glycosylation (HP:0012346)2.80824867
31Abnormal glycosylation (HP:0012345)2.80824867
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80824867
33Abnormal protein N-linked glycosylation (HP:0012347)2.80824867
34Squamous cell carcinoma (HP:0002860)2.78021412
35Facial diplegia (HP:0001349)2.76885674
36Progressive microcephaly (HP:0000253)2.76184878
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.76175604
38Pterygium (HP:0001059)2.69794221
39Abnormal albumin level (HP:0012116)2.66745068
40Hypoalbuminemia (HP:0003073)2.66745068
41Fair hair (HP:0002286)2.62924299
42Prolonged QT interval (HP:0001657)2.60739314
43Premature graying of hair (HP:0002216)2.59333117
44Albinism (HP:0001022)2.58017608
45Ectopic kidney (HP:0000086)2.56889198
46Thin bony cortex (HP:0002753)2.54956361
47Renal Fanconi syndrome (HP:0001994)2.54119862
48Flat occiput (HP:0005469)2.53097603
49Ulnar bowing (HP:0003031)2.50288427
50Widely patent fontanelles and sutures (HP:0004492)2.44895977
51Hypoplasia of the pons (HP:0012110)2.40397101
52Dyschromatopsia (HP:0007641)2.39741448
53Protruding tongue (HP:0010808)2.39445902
54Increased number of teeth (HP:0011069)2.39319881
55Congenital sensorineural hearing impairment (HP:0008527)2.38824306
56Thin ribs (HP:0000883)2.36937297
57Hyperkalemia (HP:0002153)2.36067285
58Epiphyseal stippling (HP:0010655)2.35736940
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35121181
60Breast hypoplasia (HP:0003187)2.29509767
61Decreased circulating renin level (HP:0003351)2.28618184
62Generalized hypopigmentation of hair (HP:0011358)2.26499294
63Short chin (HP:0000331)2.25793440
64Fatigable weakness (HP:0003473)2.25566908
65Abnormality of the neuromuscular junction (HP:0003398)2.25566908
66Aplasia of the musculature (HP:0100854)2.24255155
67Abnormality of the intrinsic pathway (HP:0010989)2.23659216
68Type I transferrin isoform profile (HP:0003642)2.22962410
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17805409
70Abnormality of the pons (HP:0007361)2.15947350
71Cystic hygroma (HP:0000476)2.14946700
72Hypoplasia of the radius (HP:0002984)2.11975900
73Short middle phalanx of the 5th finger (HP:0004220)2.05177794
74Short thumb (HP:0009778)2.04699611
75Cerebellar dysplasia (HP:0007033)2.04376099
76Poor head control (HP:0002421)2.02996626
77Prolonged partial thromboplastin time (HP:0003645)2.01484272
78Slender long bone (HP:0003100)1.97241803
79Prominent nose (HP:0000448)1.95246646
80Abnormal epiphyseal ossification (HP:0010656)1.94246844
81Absent speech (HP:0001344)1.93838732
82Joint stiffness (HP:0001387)1.83954528
83Macular degeneration (HP:0000608)1.83185969
84Brushfield spots (HP:0001088)1.82550594
85Reduced antithrombin III activity (HP:0001976)1.82329888
86Anteriorly placed anus (HP:0001545)1.81580262
87Hemorrhage of the eye (HP:0011885)1.81247996
88Polydipsia (HP:0001959)1.80233451
89Abnormal drinking behavior (HP:0030082)1.80233451
90Absent radius (HP:0003974)1.79734575
91Intellectual disability, progressive (HP:0006887)1.79513365
92Neonatal respiratory distress (HP:0002643)1.77835259
93Ocular albinism (HP:0001107)1.76622750
94Lip pit (HP:0100267)1.74296533
95Joint hemorrhage (HP:0005261)1.71912523
96Atrial fibrillation (HP:0005110)1.71137864
97Polymicrogyria (HP:0002126)1.69906545
98Abnormal finger flexion creases (HP:0006143)1.69847860
99Polyuria (HP:0000103)1.69231906
100Male infertility (HP:0003251)1.69162818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK9.24581986
2INSRR6.43395813
3MAPK154.24719050
4WNK43.01425140
5PDK22.73383798
6STK102.59583557
7FRK2.57683390
8ADRBK12.22350777
9GRK61.90435812
10BRSK21.83488698
11STK161.76403386
12BLK1.73424949
13TRIB31.48858406
14MARK31.43816725
15ADRBK21.43622573
16NUAK11.38957989
17PAK31.33438380
18DAPK21.22047870
19ACVR1B1.14164317
20MAP3K21.12703149
21CASK1.11319140
22TRIM281.10295363
23STK381.03753301
24EPHB11.00882751
25MET1.00676887
26OXSR11.00201497
27WNK10.98267489
28LRRK20.97398606
29STK390.94726514
30MAP2K10.94059550
31FER0.91546383
32PKN20.91456794
33AKT30.91309402
34MELK0.89455305
35NTRK10.84589928
36DDR20.84525774
37MAP3K30.83123355
38GSK3A0.80599104
39PDGFRB0.79674781
40ZAP700.73398301
41MAP2K20.73393915
42CDK120.70421706
43PBK0.70039512
44VRK20.69573036
45EPHA40.65109164
46ATR0.64714549
47NEK90.64388493
48FLT30.57655334
49BMPR20.57283342
50BMPR1B0.56403003
51BMX0.54915339
52CAMK10.54725649
53PRKD10.53833365
54TYRO30.53750922
55PNCK0.52934597
56STK38L0.52660260
57PRKAA10.51689862
58PRKAA20.50899797
59TNK20.50310398
60CAMK1G0.50302813
61PAK10.44438392
62NEK60.43898271
63IKBKE0.43418688
64CDK40.41432497
65GRK10.41216366
66ROCK10.40535741
67WNK30.39851624
68EPHA30.39290838
69MAPK110.38317650
70MAP3K80.38201516
71CAMK40.38057785
72RET0.34922525
73PRKCI0.34030109
74CAMKK20.33168492
75DYRK30.32333342
76RPS6KA60.31835635
77STK110.29482946
78CHUK0.29142049
79IKBKB0.28442493
80PTK20.27897795
81PKN10.27460971
82PRKACG0.27137117
83PDPK10.26870565
84IRAK20.26102043
85MTOR0.25468696
86CHEK20.25362073
87TGFBR10.24985295
88CAMK1D0.24488817
89PIM20.23619516
90MAPK10.23564118
91MAPK130.23021038
92PRKACA0.22296216
93PRKCH0.21948092
94TBK10.20593661
95PRKCQ0.19846173
96MAPK30.19248843
97HIPK20.18670094
98IRAK40.18088083
99PTK60.17864214
100MAPKAPK50.17603639

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006046.64133090
2Sulfur relay system_Homo sapiens_hsa041225.22394130
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006015.21878730
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.23076640
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.86118484
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.55007053
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.25613345
8Taste transduction_Homo sapiens_hsa047421.97943403
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97200809
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82984044
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76201849
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.64580287
13Fanconi anemia pathway_Homo sapiens_hsa034601.63444059
14Linoleic acid metabolism_Homo sapiens_hsa005911.58553837
15Sphingolipid metabolism_Homo sapiens_hsa006001.58061187
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54915002
17Homologous recombination_Homo sapiens_hsa034401.52429862
18Phototransduction_Homo sapiens_hsa047441.38743107
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36855945
20N-Glycan biosynthesis_Homo sapiens_hsa005101.32420127
21Circadian rhythm_Homo sapiens_hsa047101.28721623
22Ovarian steroidogenesis_Homo sapiens_hsa049131.25827231
23Butanoate metabolism_Homo sapiens_hsa006501.24552950
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.24460312
25Nicotine addiction_Homo sapiens_hsa050331.22812645
26RNA polymerase_Homo sapiens_hsa030201.22409914
27Vitamin digestion and absorption_Homo sapiens_hsa049771.19832932
28Lysine degradation_Homo sapiens_hsa003101.19144299
29Chemical carcinogenesis_Homo sapiens_hsa052041.14145150
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12376920
31Ether lipid metabolism_Homo sapiens_hsa005651.10826930
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.09918744
33Dorso-ventral axis formation_Homo sapiens_hsa043201.06600582
34Basal transcription factors_Homo sapiens_hsa030221.01003817
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97679873
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94953416
37Other glycan degradation_Homo sapiens_hsa005110.92232758
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89988758
39Selenocompound metabolism_Homo sapiens_hsa004500.86022674
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85920889
41Calcium signaling pathway_Homo sapiens_hsa040200.83270017
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78771976
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.77231183
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.68732817
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68587308
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63986657
47Retinol metabolism_Homo sapiens_hsa008300.63383483
48Cell cycle_Homo sapiens_hsa041100.63178509
49Glycerolipid metabolism_Homo sapiens_hsa005610.61571880
50Hedgehog signaling pathway_Homo sapiens_hsa043400.61406909
51Lysosome_Homo sapiens_hsa041420.58727554
52Tyrosine metabolism_Homo sapiens_hsa003500.54510044
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53988149
54Fructose and mannose metabolism_Homo sapiens_hsa000510.51217082
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48310474
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47697583
57Measles_Homo sapiens_hsa051620.45868264
58Peroxisome_Homo sapiens_hsa041460.45210401
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45111017
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45065977
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44710143
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42834164
63Arachidonic acid metabolism_Homo sapiens_hsa005900.41047604
64Prostate cancer_Homo sapiens_hsa052150.40918078
65Metabolic pathways_Homo sapiens_hsa011000.40899662
66Bile secretion_Homo sapiens_hsa049760.40645422
67RNA degradation_Homo sapiens_hsa030180.40127626
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34020466
69Inositol phosphate metabolism_Homo sapiens_hsa005620.32116305
70Pyrimidine metabolism_Homo sapiens_hsa002400.31588907
71Huntingtons disease_Homo sapiens_hsa050160.31097383
72Mineral absorption_Homo sapiens_hsa049780.30939618
73Morphine addiction_Homo sapiens_hsa050320.28844675
74Tryptophan metabolism_Homo sapiens_hsa003800.27839778
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27269764
76p53 signaling pathway_Homo sapiens_hsa041150.27179940
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26996776
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.26358086
79Glutathione metabolism_Homo sapiens_hsa004800.25222077
80ABC transporters_Homo sapiens_hsa020100.23866119
81Melanoma_Homo sapiens_hsa052180.23715158
82Fat digestion and absorption_Homo sapiens_hsa049750.23467429
83Melanogenesis_Homo sapiens_hsa049160.23318770
84Cholinergic synapse_Homo sapiens_hsa047250.22759731
85Basal cell carcinoma_Homo sapiens_hsa052170.22694174
86cAMP signaling pathway_Homo sapiens_hsa040240.22584139
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.17068530
88Insulin resistance_Homo sapiens_hsa049310.16530307
89Base excision repair_Homo sapiens_hsa034100.15550309
90Olfactory transduction_Homo sapiens_hsa047400.14319541
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.12890219
92TNF signaling pathway_Homo sapiens_hsa046680.12464371
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.12415175
94Cocaine addiction_Homo sapiens_hsa050300.12325620
95Starch and sucrose metabolism_Homo sapiens_hsa005000.11582635
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10315763
97Prolactin signaling pathway_Homo sapiens_hsa049170.09474361
98Oocyte meiosis_Homo sapiens_hsa041140.08914614
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08646754
100beta-Alanine metabolism_Homo sapiens_hsa004100.08357034

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