TGM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.10104157
2low-density lipoprotein particle clearance (GO:0034383)4.52858565
3mesodermal cell differentiation (GO:0048333)4.48176743
4skin morphogenesis (GO:0043589)4.20943349
5Golgi transport vesicle coating (GO:0048200)4.20850713
6COPI coating of Golgi vesicle (GO:0048205)4.20850713
7substrate-dependent cell migration (GO:0006929)4.20443331
8cell-substrate junction assembly (GO:0007044)4.01581928
9lung vasculature development (GO:0060426)3.98705399
10protein localization to endosome (GO:0036010)3.85640210
11endodermal cell differentiation (GO:0035987)3.79731305
12regulation of cholesterol storage (GO:0010885)3.78389665
13desmosome organization (GO:0002934)3.70831687
14wound healing, spreading of epidermal cells (GO:0035313)3.70435377
15epithelial cell-cell adhesion (GO:0090136)3.61086312
16complement activation, alternative pathway (GO:0006957)3.53918365
17barbed-end actin filament capping (GO:0051016)3.49819994
18plasma lipoprotein particle clearance (GO:0034381)3.48359632
19regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.46476250
20negative regulation of chondrocyte differentiation (GO:0032331)3.45193139
21retina vasculature morphogenesis in camera-type eye (GO:0061299)3.43496295
22protein carboxylation (GO:0018214)3.36953805
23peptidyl-glutamic acid carboxylation (GO:0017187)3.36953805
24renal filtration (GO:0097205)3.36198862
25hypotonic response (GO:0006971)3.34952937
26negative regulation of fibrinolysis (GO:0051918)3.34934848
27muscle cell migration (GO:0014812)3.34514764
28fatty acid transmembrane transport (GO:1902001)3.31495118
29phospholipid homeostasis (GO:0055091)3.31119161
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31001190
31dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.26672966
32protein retention in ER lumen (GO:0006621)3.26364779
33positive regulation of odontogenesis (GO:0042482)3.26203140
34vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.22260561
35endothelial cell morphogenesis (GO:0001886)3.21910402
36regulation of protein activation cascade (GO:2000257)3.19249949
37lysine metabolic process (GO:0006553)3.17025463
38lysine catabolic process (GO:0006554)3.17025463
39positive regulation of p38MAPK cascade (GO:1900745)3.16939103
40positive regulation of extracellular matrix organization (GO:1903055)3.16655956
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.14221870
42wound healing, spreading of cells (GO:0044319)3.13639411
43regulation of complement activation (GO:0030449)3.13129740
44cytoskeletal anchoring at plasma membrane (GO:0007016)3.12897638
45alpha-linolenic acid metabolic process (GO:0036109)3.12764156
46positive regulation of blood vessel endothelial cell migration (GO:0043536)3.12694063
47membrane raft organization (GO:0031579)3.12358229
48hyaluronan catabolic process (GO:0030214)3.09029947
49positive regulation of lipid storage (GO:0010884)3.08506260
50regulation of sequestering of triglyceride (GO:0010889)3.06846519
51positive regulation of osteoblast proliferation (GO:0033690)3.06530496
52negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.04228064
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00245443
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.00245443
55positive regulation of receptor recycling (GO:0001921)3.00164801
56atrioventricular valve morphogenesis (GO:0003181)2.99499996
57actin filament depolymerization (GO:0030042)2.98954153
58bundle of His cell to Purkinje myocyte communication (GO:0086069)2.98458106
59adherens junction assembly (GO:0034333)2.98064280
60focal adhesion assembly (GO:0048041)2.97387611
61cell-substrate adherens junction assembly (GO:0007045)2.97387611
62endothelium development (GO:0003158)2.96892617
63carnitine shuttle (GO:0006853)2.96413304
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95662428
65sulfur amino acid catabolic process (GO:0000098)2.95069966
66endocardial cushion development (GO:0003197)2.94895250
67regulation of transforming growth factor beta2 production (GO:0032909)2.93325197
68cysteine metabolic process (GO:0006534)2.93197718
69lymphangiogenesis (GO:0001946)2.91982990
70regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.91767498
71semaphorin-plexin signaling pathway (GO:0071526)2.88934005
72positive regulation of endothelial cell apoptotic process (GO:2000353)2.87971255
73positive regulation of blood coagulation (GO:0030194)2.87709120
74positive regulation of hemostasis (GO:1900048)2.87709120
75negative regulation of lipid storage (GO:0010888)2.86583157
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.86063271
77blood vessel maturation (GO:0001955)2.85752826
78glyoxylate metabolic process (GO:0046487)2.85506601
79stress fiber assembly (GO:0043149)2.84957693
80fatty acid beta-oxidation (GO:0006635)2.84775805
81regulation of metalloenzyme activity (GO:0048552)2.83173762
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82655076
83L-phenylalanine metabolic process (GO:0006558)2.82655076
842-oxoglutarate metabolic process (GO:0006103)2.82194771
85regulation of cardioblast differentiation (GO:0051890)2.81334270
86regulation of triglyceride catabolic process (GO:0010896)2.81218020
87valine metabolic process (GO:0006573)2.80938338
88regulation of transforming growth factor beta1 production (GO:0032908)2.80248111
89endothelial cell chemotaxis (GO:0035767)2.79340605
90cell adhesion mediated by integrin (GO:0033627)2.78890448
91regulation of glomerular filtration (GO:0003093)2.78882068
92vascular endothelial growth factor signaling pathway (GO:0038084)2.78072342
93regulation of cholesterol homeostasis (GO:2000188)2.77960452
94regulation of fibrinolysis (GO:0051917)2.75627085
95positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75398626
96positive regulation of fatty acid beta-oxidation (GO:0032000)2.75227530
97membrane protein ectodomain proteolysis (GO:0006509)2.73974686
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.73458065
99L-phenylalanine catabolic process (GO:0006559)2.73458065
100positive regulation of coagulation (GO:0050820)2.73402124
101fatty acid oxidation (GO:0019395)2.71546623
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70954290
103urea metabolic process (GO:0019627)2.70927656
104urea cycle (GO:0000050)2.70927656
105antigen processing and presentation of endogenous antigen (GO:0019883)2.70664922
106amino-acid betaine metabolic process (GO:0006577)2.68283347
107iron ion import (GO:0097286)2.68181890
108protein maturation by protein folding (GO:0022417)2.67791717
109positive regulation of epithelial cell migration (GO:0010634)2.67624129
110type B pancreatic cell proliferation (GO:0044342)2.67530348
111lipid oxidation (GO:0034440)2.66505506
112negative regulation of fatty acid transport (GO:2000192)2.66217193
113* apoptotic cell clearance (GO:0043277)2.65678261
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.65473114
115regulation of p38MAPK cascade (GO:1900744)2.63550484
116positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.63130624
117acute-phase response (GO:0006953)2.61625238
118fibrinolysis (GO:0042730)2.60290178
119extracellular fibril organization (GO:0043206)2.59227656
120positive regulation of lipid catabolic process (GO:0050996)2.58721443
121lung lobe morphogenesis (GO:0060463)2.58340836
122growth hormone receptor signaling pathway (GO:0060396)2.58201251
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.58157768
124homocysteine metabolic process (GO:0050667)2.57847786
125substrate adhesion-dependent cell spreading (GO:0034446)2.57074984
126surfactant homeostasis (GO:0043129)2.56617141
127triglyceride homeostasis (GO:0070328)2.56054309
128acylglycerol homeostasis (GO:0055090)2.56054309
129ethanol oxidation (GO:0006069)2.55696316
130kynurenine metabolic process (GO:0070189)2.55114504
131extracellular matrix disassembly (GO:0022617)2.55019274
132positive regulation of fatty acid oxidation (GO:0046321)2.54639923
133protein hydroxylation (GO:0018126)2.53696062
134negative regulation of anoikis (GO:2000811)2.53271969
135reverse cholesterol transport (GO:0043691)2.52942109
136positive regulation of endothelial cell migration (GO:0010595)2.52936038
137carnitine metabolic process (GO:0009437)2.50634914
138sarcomere organization (GO:0045214)2.50563299
139negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.50304980
140pinocytosis (GO:0006907)2.49819996
141chondrocyte proliferation (GO:0035988)2.49624480
142collagen metabolic process (GO:0032963)2.49415491
143negative regulation of cartilage development (GO:0061037)2.49289417
144platelet degranulation (GO:0002576)2.48656997
145regulation of fatty acid beta-oxidation (GO:0031998)2.48317476
146regulation of macrophage derived foam cell differentiation (GO:0010743)2.47365106
147positive regulation by organism of defense response of other organism involved in symbiotic interact2.47184837
148modulation by symbiont of host immune response (GO:0052553)2.47184837
149positive regulation by symbiont of host defense response (GO:0052509)2.47184837
150modulation by symbiont of host defense response (GO:0052031)2.47184837
151modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47184837
152modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47184837
153regulation of membrane protein ectodomain proteolysis (GO:0051043)2.46730949
154regulation of lipid storage (GO:0010883)2.46642686
155high-density lipoprotein particle remodeling (GO:0034375)2.46532069
156nitrogen cycle metabolic process (GO:0071941)2.45787181
157regulation of fatty acid oxidation (GO:0046320)2.44823051
158venous blood vessel morphogenesis (GO:0048845)2.44585077
159gap junction assembly (GO:0016264)2.44543489
160cellular response to vitamin D (GO:0071305)2.42626781
161fatty acid catabolic process (GO:0009062)2.42617861
162aromatic amino acid family catabolic process (GO:0009074)2.41481086
163pathway-restricted SMAD protein phosphorylation (GO:0060389)2.41075309
164positive regulation of adherens junction organization (GO:1903393)2.41051705
165regulation of blood vessel endothelial cell migration (GO:0043535)2.40656979
166carnitine transmembrane transport (GO:1902603)2.40000931
167amino-acid betaine transport (GO:0015838)2.39609542
168carnitine transport (GO:0015879)2.39609542
169platelet-derived growth factor receptor signaling pathway (GO:0048008)2.39508004
170tricarboxylic acid metabolic process (GO:0072350)2.39239424
171multicellular organismal macromolecule metabolic process (GO:0044259)2.38226210
172cell junction assembly (GO:0034329)2.37976556
173fibril organization (GO:0097435)2.37880129
174cell volume homeostasis (GO:0006884)2.37617772
175positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.37249892
176positive regulation of cartilage development (GO:0061036)2.37019079
177peptidyl-proline hydroxylation (GO:0019511)2.36929774
178positive regulation of triglyceride metabolic process (GO:0090208)2.36792919
179basement membrane organization (GO:0071711)2.34840079
180regulation of plasminogen activation (GO:0010755)2.34829264
181lipoprotein metabolic process (GO:0042157)2.34726552
182detection of molecule of bacterial origin (GO:0032490)2.31936335
183phospholipid efflux (GO:0033700)2.31670326
184cholesterol homeostasis (GO:0042632)2.31085332
185sterol homeostasis (GO:0055092)2.30839714
186brown fat cell differentiation (GO:0050873)2.28665380
187negative regulation of protein autophosphorylation (GO:0031953)2.27958784
188cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.27893297
189acetyl-CoA metabolic process (GO:0006084)2.27772456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.42590739
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.21984663
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.04405580
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.64900724
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.42573054
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.23256329
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.87203767
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.81443769
9* CLOCK_20551151_ChIP-Seq_293T_Human2.75756752
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70896852
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.70896563
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67566577
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.50511192
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43828682
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36469855
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.36411752
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.27670277
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25871713
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19363976
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19065971
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.07377836
22* ESR2_21235772_ChIP-Seq_MCF-7_Human2.00667492
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99963524
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98286739
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92166395
26* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84715248
27* GATA2_21666600_ChIP-Seq_HMVEC_Human1.84453415
28* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82120813
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.76485575
30* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75693416
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.74019333
32GATA1_22025678_ChIP-Seq_K562_Human1.73730156
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.68161358
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67440444
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65804260
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.64743614
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.63029065
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62807002
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59543986
40* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55452943
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54626473
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.51878207
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51563064
44ZNF263_19887448_ChIP-Seq_K562_Human1.51400785
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48668138
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48148621
47UBF1/2_26484160_Chip-Seq_HMECs_Human1.48049755
48BRD4_25478319_ChIP-Seq_HGPS_Human1.46909004
49* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42197519
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42030020
51* TBX20_22080862_ChIP-Seq_HEART_Mouse1.38714774
52* TBX20_22328084_ChIP-Seq_HEART_Mouse1.38714774
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.38293959
54TP53_22127205_ChIP-Seq_IMR90_Human1.38156544
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37296440
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35952140
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32935193
58LXR_22292898_ChIP-Seq_THP-1_Human1.32891916
59RACK7_27058665_Chip-Seq_MCF-7_Human1.32243388
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31618968
61* GATA1_19941826_ChIP-Seq_K562_Human1.24140410
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.23372342
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22865454
64* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20585707
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20246851
66* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19162045
67* SOX2_20726797_ChIP-Seq_SW620_Human1.18741793
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18729653
69* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18726964
70KDM2B_26808549_Chip-Seq_K562_Human1.18679311
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15771018
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15457293
73* FOXA2_19822575_ChIP-Seq_HepG2_Human1.14750360
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14466032
75ATF3_27146783_Chip-Seq_COLON_Human1.12546837
76TP53_23651856_ChIP-Seq_MEFs_Mouse1.12079084
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.11684847
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11400674
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09637335
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09624898
81TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09492013
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08590726
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07287044
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07204554
85* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07166366
86* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07166366
87* GATA2_19941826_ChIP-Seq_K562_Human1.06428533
88* CDX2_20551321_ChIP-Seq_CACO-2_Human1.06356476
89* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06044308
90* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05618256
91CJUN_26792858_Chip-Seq_BT549_Human1.05484662
92GATA4_25053715_ChIP-Seq_YYC3_Human1.05163232
93TCF7_22412390_ChIP-Seq_EML_Mouse1.03757608
94* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03606918
95SCL_19346495_ChIP-Seq_HPC-7_Human1.03050448
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03023768
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02810513
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00210907
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99981486
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99802186
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99713428
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99564557
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98789130
104P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98772291
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98576837
106CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98051351
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97629989
108AHR_22903824_ChIP-Seq_MCF-7_Human0.96899677
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96738209
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96454211
111VDR_24787735_ChIP-Seq_THP-1_Human0.95807266
112MAF_26560356_Chip-Seq_TH1_Human0.95403321
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95175731
114GATA6_25053715_ChIP-Seq_YYC3_Human0.94658224
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.94213492
116* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93951980
117KDM2B_26808549_Chip-Seq_DND41_Human0.93897410
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93563111
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92907566
120* KLF5_25053715_ChIP-Seq_YYC3_Human0.92514556
121* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92240321
122* SPI1_23127762_ChIP-Seq_K562_Human0.92116009
123VDR_21846776_ChIP-Seq_THP-1_Human0.91563567
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91019945
125VDR_24763502_ChIP-Seq_THP-1_Human0.90915496
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90235118
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89446045
128MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88894129
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87565895
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87302672
131* TP63_22573176_ChIP-Seq_HFKS_Human0.86839360
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85771359
133RUNX1_27514584_Chip-Seq_MCF-7_Human0.85141682
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84851886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.20062840
2MP0005360_urolithiasis3.01855258
3MP0002877_abnormal_melanocyte_morpholog2.76895680
4MP0003191_abnormal_cellular_cholesterol2.69206825
5MP0005365_abnormal_bile_salt2.54011089
6MP0003950_abnormal_plasma_membrane2.49578519
7MP0005623_abnormal_meninges_morphology2.42801520
8MP0010368_abnormal_lymphatic_system2.36455604
9MP0009840_abnormal_foam_cell2.34572068
10MP0003705_abnormal_hypodermis_morpholog2.31777065
11MP0003724_increased_susceptibility_to2.29963151
12MP0005085_abnormal_gallbladder_physiolo2.25881398
13MP0008875_abnormal_xenobiotic_pharmacok2.17631028
14MP0008438_abnormal_cutaneous_collagen2.15368927
15MP0005257_abnormal_intraocular_pressure2.10950921
16MP0002138_abnormal_hepatobiliary_system2.06190154
17MP0004084_abnormal_cardiac_muscle2.03112165
18MP0010329_abnormal_lipoprotein_level1.92748918
19MP0004130_abnormal_muscle_cell1.92676481
20MP0004510_myositis1.89429528
21MP0003300_gastrointestinal_ulcer1.86407367
22MP0005167_abnormal_blood-brain_barrier1.84461288
23MP0003303_peritoneal_inflammation1.81426086
24MP0001849_ear_inflammation1.77668757
25MP0003252_abnormal_bile_duct1.77398326
26* MP0003566_abnormal_cell_adhesion1.68003540
27MP0005670_abnormal_white_adipose1.67801089
28MP0005058_abnormal_lysosome_morphology1.66000637
29MP0002837_dystrophic_cardiac_calcinosis1.65621367
30MP0002254_reproductive_system_inflammat1.62652629
31MP0003828_pulmonary_edema1.62641370
32MP0001958_emphysema1.60666005
33MP0003436_decreased_susceptibility_to1.60481822
34MP0005083_abnormal_biliary_tract1.57396785
35MP0004858_abnormal_nervous_system1.56379867
36MP0001879_abnormal_lymphatic_vessel1.56273746
37MP0005666_abnormal_adipose_tissue1.48362741
38* MP0000343_altered_response_to1.46574043
39MP0000609_abnormal_liver_physiology1.44954029
40MP0000013_abnormal_adipose_tissue1.43826744
41MP0004272_abnormal_basement_membrane1.42741583
42MP0006054_spinal_hemorrhage1.42517779
43MP0005451_abnormal_body_composition1.41715847
44MP0010234_abnormal_vibrissa_follicle1.41601982
45MP0002060_abnormal_skin_morphology1.40784905
46MP0000858_altered_metastatic_potential1.38091585
47MP0010030_abnormal_orbit_morphology1.37853805
48MP0005319_abnormal_enzyme/_coenzyme1.37497394
49MP0009278_abnormal_bone_marrow1.36266087
50MP0005409_darkened_coat_color1.35813659
51MP0002896_abnormal_bone_mineralization1.34109046
52MP0005330_cardiomyopathy1.33766929
53MP0005275_abnormal_skin_tensile1.32512638
54MP0002295_abnormal_pulmonary_circulatio1.31522868
55MP0009785_altered_susceptibility_to1.31175658
56MP0004036_abnormal_muscle_relaxation1.31039888
57MP0008775_abnormal_heart_ventricle1.30529010
58MP0005332_abnormal_amino_acid1.28352850
59MP0004185_abnormal_adipocyte_glucose1.26807561
60MP0005595_abnormal_vascular_smooth1.25943866
61MP0000537_abnormal_urethra_morphology1.25697218
62MP0002118_abnormal_lipid_homeostasis1.25369003
63MP0009780_abnormal_chondrocyte_physiolo1.23443553
64MP0004019_abnormal_vitamin_homeostasis1.21711057
65MP0003806_abnormal_nucleotide_metabolis1.21521498
66MP0000678_abnormal_parathyroid_gland1.21216553
67MP0005464_abnormal_platelet_physiology1.21200366
68MP0000762_abnormal_tongue_morphology1.17769000
69MP0000751_myopathy1.17560717
70MP0001533_abnormal_skeleton_physiology1.16061978
71MP0009643_abnormal_urine_homeostasis1.15806948
72MP0005023_abnormal_wound_healing1.15267700
73MP0010630_abnormal_cardiac_muscle1.14595820
74MP0004233_abnormal_muscle_weight1.13877090
75MP0001666_abnormal_nutrient_absorption1.12427885
76MP0002933_joint_inflammation1.12267621
77MP0000003_abnormal_adipose_tissue1.12226144
78MP0000733_abnormal_muscle_development1.11646460
79MP0000249_abnormal_blood_vessel1.11126488
80MP0008469_abnormal_protein_level1.10928364
81MP0000750_abnormal_muscle_regeneration1.10902319
82* MP0002419_abnormal_innate_immunity1.10603188
83MP0001915_intracranial_hemorrhage1.10431674
84MP0005197_abnormal_uvea_morphology1.10196291
85MP0005508_abnormal_skeleton_morphology1.09879703
86MP0005375_adipose_tissue_phenotype1.08439246
87MP0004947_skin_inflammation1.08156277
88MP0000534_abnormal_ureter_morphology1.07894986
89MP0005164_abnormal_response_to1.07637748
90* MP0001544_abnormal_cardiovascular_syste1.06638215
91* MP0005385_cardiovascular_system_phenoty1.06638215
92MP0001614_abnormal_blood_vessel1.06416136
93MP0001835_abnormal_antigen_presentation1.05121837
94MP0000767_abnormal_smooth_muscle1.04852252
95* MP0009764_decreased_sensitivity_to1.04663466
96MP0004087_abnormal_muscle_fiber1.02880708
97MP0002972_abnormal_cardiac_muscle1.01865835
98MP0003075_altered_response_to1.01662701
99MP0005025_abnormal_response_to1.00914763
100MP0003329_amyloid_beta_deposits1.00722623
101MP0003453_abnormal_keratinocyte_physiol1.00488075
102MP0000604_amyloidosis1.00281334
103MP0003941_abnormal_skin_development0.99949216
104MP0005503_abnormal_tendon_morphology0.99773370
105MP0000685_abnormal_immune_system0.99040081
106MP0006138_congestive_heart_failure0.98604282
107MP0004782_abnormal_surfactant_physiolog0.97218147
108MP0003279_aneurysm0.96972477
109MP0000467_abnormal_esophagus_morphology0.96011021
110MP0009053_abnormal_anal_canal0.95174381
111MP0002925_abnormal_cardiovascular_devel0.95112726
112MP0000749_muscle_degeneration0.94702968
113MP0005165_increased_susceptibility_to0.93782411
114MP0010352_gastrointestinal_tract_polyps0.93318390
115MP0004215_abnormal_myocardial_fiber0.91409781
116MP0001348_abnormal_lacrimal_gland0.90513667
117MP0002971_abnormal_brown_adipose0.90454387
118MP0003186_abnormal_redox_activity0.89533373
119MP0005584_abnormal_enzyme/coenzyme_acti0.89510325
120MP0002168_other_aberrant_phenotype0.89270329
121MP0000598_abnormal_liver_morphology0.89037176
122MP0008004_abnormal_stomach_pH0.86495277
123MP0006082_CNS_inflammation0.86397194
124MP0004883_abnormal_blood_vessel0.85739426
125MP0002998_abnormal_bone_remodeling0.85664919
126MP0001853_heart_inflammation0.85599150
127* MP0009763_increased_sensitivity_to0.85306147
128* MP0001845_abnormal_inflammatory_respons0.84484830
129MP0001542_abnormal_bone_strength0.84213043
130MP0002136_abnormal_kidney_physiology0.83859543
131MP0003091_abnormal_cell_migration0.83076296
132MP0005390_skeleton_phenotype0.82948110
133MP0003656_abnormal_erythrocyte_physiolo0.82499559
134MP0005166_decreased_susceptibility_to0.82029406
135MP0001790_abnormal_immune_system0.81790463
136MP0005387_immune_system_phenotype0.81790463
137MP0010155_abnormal_intestine_physiology0.81740392
138MP0003646_muscle_fatigue0.81566170
139MP0002128_abnormal_blood_circulation0.81229237
140MP0005076_abnormal_cell_differentiation0.80716295
141MP0003195_calcinosis0.79091830
142MP0009384_cardiac_valve_regurgitation0.79079395
143* MP0003448_altered_tumor_morphology0.75401247
144MP0002796_impaired_skin_barrier0.74301943
145MP0003045_fibrosis0.73267085
146MP0000759_abnormal_skeletal_muscle0.73077411
147MP0001243_abnormal_dermal_layer0.71172487
148MP0002332_abnormal_exercise_endurance0.69507041
149MP0005501_abnormal_skin_physiology0.68976357

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.63634794
2Arterial tortuosity (HP:0005116)5.04621580
3Vascular tortuosity (HP:0004948)4.78666102
4Deep venous thrombosis (HP:0002625)4.10592382
5Atrophic scars (HP:0001075)3.93178124
6Cervical subluxation (HP:0003308)3.87779195
7Right ventricular cardiomyopathy (HP:0011663)3.83526766
8Distal lower limb amyotrophy (HP:0008944)3.59474187
9Complement deficiency (HP:0004431)3.53900838
10Esophageal varix (HP:0002040)3.49553585
11Vertebral compression fractures (HP:0002953)3.40804955
12Xanthomatosis (HP:0000991)3.40618857
13Distal lower limb muscle weakness (HP:0009053)3.25640198
14Polycythemia (HP:0001901)3.23833463
15Short nail (HP:0001799)3.23655882
16Fragile skin (HP:0001030)3.22753801
17Myocardial infarction (HP:0001658)3.18397090
18Asymmetric septal hypertrophy (HP:0001670)3.08888315
19Joint hemorrhage (HP:0005261)3.08821780
20Distal upper limb amyotrophy (HP:0007149)3.08100047
21Upper limb amyotrophy (HP:0009129)3.08100047
22Increased connective tissue (HP:0009025)3.06514542
23Broad face (HP:0000283)3.05331711
24Systemic lupus erythematosus (HP:0002725)3.05182661
25Ventricular tachycardia (HP:0004756)2.99193257
26Intrahepatic cholestasis (HP:0001406)2.92350462
27Spinal rigidity (HP:0003306)2.90469209
28Hematochezia (HP:0002573)2.90096757
29Wormian bones (HP:0002645)2.83881202
30Hypoalphalipoproteinemia (HP:0003233)2.83379792
31Abnormality of complement system (HP:0005339)2.80041337
32Muscle fiber splitting (HP:0003555)2.76892674
33Cerebral aneurysm (HP:0004944)2.76496253
34Abnormality of glutamine family amino acid metabolism (HP:0010902)2.76018073
35Recurrent gram-negative bacterial infections (HP:0005420)2.68620044
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67621449
37Sudden death (HP:0001699)2.64534103
38Spondylolisthesis (HP:0003302)2.64293985
39Interstitial pulmonary disease (HP:0006530)2.59189052
40Abnormality of the common coagulation pathway (HP:0010990)2.59177393
41Hyporeflexia of lower limbs (HP:0002600)2.56534274
42Focal segmental glomerulosclerosis (HP:0000097)2.53315478
43Hypoglycemic coma (HP:0001325)2.51493415
44Hyperammonemia (HP:0001987)2.50099338
45Spontaneous hematomas (HP:0007420)2.48609493
46Hyperlipoproteinemia (HP:0010980)2.48418351
47Lower limb amyotrophy (HP:0007210)2.48103558
48Aortic aneurysm (HP:0004942)2.47387523
49Difficulty climbing stairs (HP:0003551)2.45698530
50Ankle contracture (HP:0006466)2.45343777
51Abnormality of proline metabolism (HP:0010907)2.44628138
52Hydroxyprolinuria (HP:0003080)2.44628138
53Tetraparesis (HP:0002273)2.42756740
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.42456316
55Amyloidosis (HP:0011034)2.42358631
56Mildly elevated creatine phosphokinase (HP:0008180)2.41147026
57Nephritis (HP:0000123)2.36334008
58Menorrhagia (HP:0000132)2.35470399
59Abnormality of fatty-acid metabolism (HP:0004359)2.35165853
60Hypolipoproteinemia (HP:0010981)2.33857466
61Dilatation of the ascending aorta (HP:0005111)2.32397468
62Wrist flexion contracture (HP:0001239)2.31429509
63Exercise-induced muscle cramps (HP:0003710)2.31037715
64Abnormality of the nasal mucosa (HP:0000433)2.30363838
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30297501
66Increased cerebral lipofuscin (HP:0011813)2.30245945
67Myoglobinuria (HP:0002913)2.29503934
68Shallow orbits (HP:0000586)2.29197044
69Ketosis (HP:0001946)2.29141204
70Glucose intolerance (HP:0000833)2.28311467
71Lipoatrophy (HP:0100578)2.27068896
72Axonal loss (HP:0003447)2.26236720
73Eczematoid dermatitis (HP:0000976)2.26145459
74Hemorrhage of the eye (HP:0011885)2.25086474
75Bladder diverticulum (HP:0000015)2.24477134
76Flat acetabular roof (HP:0003180)2.23440362
77Mitral stenosis (HP:0001718)2.23368639
78Blue sclerae (HP:0000592)2.20985855
79Aortic dissection (HP:0002647)2.20882192
80Abnormality of the acetabulum (HP:0003170)2.19858725
81Hyperacusis (HP:0010780)2.18124424
82Abnormality of purine metabolism (HP:0004352)2.17821977
83Aneurysm (HP:0002617)2.17715441
84Skin nodule (HP:0200036)2.17341644
85Nuclear cataract (HP:0100018)2.16363878
86Hyperglycinuria (HP:0003108)2.15130339
87Milia (HP:0001056)2.14537094
88Cardiovascular calcification (HP:0011915)2.13818471
89Glomerulonephritis (HP:0000099)2.12314334
90Vascular calcification (HP:0004934)2.11744876
91Hypercholesterolemia (HP:0003124)2.11356345
92Glomerulosclerosis (HP:0000096)2.11118369
93Abnormality of the distal phalanges of the toes (HP:0010182)2.11031198
94Epidermoid cyst (HP:0200040)2.10957680
95Ketoacidosis (HP:0001993)2.10489521
96Abnormality of the intrinsic pathway (HP:0010989)2.10368013
97Coxa vara (HP:0002812)2.09457308
98Osteolytic defects of the hand bones (HP:0009699)2.09027894
99Osteolytic defects of the phalanges of the hand (HP:0009771)2.09027894
100Nausea (HP:0002018)2.08884262
101Trismus (HP:0000211)2.07348983
102Lymphangioma (HP:0100764)2.05511084
103Autoimmune thrombocytopenia (HP:0001973)2.04346724
104Gingival bleeding (HP:0000225)2.03996921
105Reduced subcutaneous adipose tissue (HP:0003758)2.02850299
106Neonatal death (HP:0003811)2.02718072
107Prolonged partial thromboplastin time (HP:0003645)2.01819138
108Abnormality of the vasculature of the conjunctiva (HP:0008054)2.01475657
109Joint stiffness (HP:0001387)2.01229128
110Aortic regurgitation (HP:0001659)2.00458282
111Facial diplegia (HP:0001349)1.98118884
112Elbow flexion contracture (HP:0002987)1.97689814
113Broad metatarsal (HP:0001783)1.97643942
114Hand muscle atrophy (HP:0009130)1.96040087
115Abnormality of glycolipid metabolism (HP:0010969)1.95717518
116Abnormality of liposaccharide metabolism (HP:0010968)1.95717518
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.95717518
118Disproportionate tall stature (HP:0001519)1.94909881
119Conjunctival telangiectasia (HP:0000524)1.94431515
120Mitral regurgitation (HP:0001653)1.94355882
121Alopecia of scalp (HP:0002293)1.94245790
122Increased serum ferritin (HP:0003281)1.93452183
123Onycholysis (HP:0001806)1.93340715
124Vacuolated lymphocytes (HP:0001922)1.93203608
125Abnormality of dentin (HP:0010299)1.93074533
126Abnormality of oral frenula (HP:0000190)1.92801303
127Palpitations (HP:0001962)1.92427038
128Hypobetalipoproteinemia (HP:0003563)1.90352013
129Urinary glycosaminoglycan excretion (HP:0003541)1.90214616
130Mucopolysacchariduria (HP:0008155)1.90214616
131Ulnar bowing (HP:0003031)1.90067705
132Hypertriglyceridemia (HP:0002155)1.89492148
133Abnormality of iron homeostasis (HP:0011031)1.88597542
134Abnormality of polysaccharide metabolism (HP:0011012)1.88548201
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88548201
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88548201
137Mitral valve prolapse (HP:0001634)1.87945277
138Increased variability in muscle fiber diameter (HP:0003557)1.87928321
139Peritonitis (HP:0002586)1.87768877
140Gout (HP:0001997)1.87046140
141Achilles tendon contracture (HP:0001771)1.86921979
142Premature rupture of membranes (HP:0001788)1.86804062
143Type 1 muscle fiber predominance (HP:0003803)1.86313955
144Abnormal cartilage morphology (HP:0002763)1.85347951
145Increased mean platelet volume (HP:0011877)1.84153866
146Joint laxity (HP:0001388)1.83991951
147Natal tooth (HP:0000695)1.83901098
148Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83514019
149Rhabdomyolysis (HP:0003201)1.82692638
150Ankyloglossia (HP:0010296)1.82227431
151Visceral angiomatosis (HP:0100761)1.82213414
152Stroke (HP:0001297)1.82104958
153Aortic valve stenosis (HP:0001650)1.81946942
154Thrombophlebitis (HP:0004418)1.81502679
155Dysostosis multiplex (HP:0000943)1.81490042
156Spastic diplegia (HP:0001264)1.80402775
157Atrial fibrillation (HP:0005110)1.79746076
158Long toe (HP:0010511)1.79712551
159Abnormality of glycine metabolism (HP:0010895)1.79529619
160Abnormality of serine family amino acid metabolism (HP:0010894)1.79529619
161Hepatocellular carcinoma (HP:0001402)1.79316903
162Centrally nucleated skeletal muscle fibers (HP:0003687)1.79075058
163Neurofibrillary tangles (HP:0002185)1.76847355
164Abnormality of skeletal muscle fiber size (HP:0012084)1.74861513
165Abnormality of the Achilles tendon (HP:0005109)1.73530677
166Abnormal ossification of hand bones (HP:0005921)1.73038825
167Bradycardia (HP:0001662)1.72356021
168Striae distensae (HP:0001065)1.72333713
169Hydroureter (HP:0000072)1.71934169
170Spinal cord compression (HP:0002176)1.70892814
171Thin bony cortex (HP:0002753)1.70848998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.77127709
2ERN13.43512906
3TIE13.38866717
4TTN3.17919374
5TGFBR23.01928673
6PKN22.83021378
7KDR2.50829719
8NTRK12.36252235
9RIPK12.28521705
10EPHB12.08949670
11TESK12.03213103
12TBK12.01932432
13FGFR41.97167644
14MYLK1.93116558
15LIMK11.92836855
16BCKDK1.90807562
17SIK11.83254732
18PTK61.77963861
19TYK21.65315315
20MAP3K31.63509985
21MAP2K31.53233569
22MST1R1.48215220
23EPHA21.45845310
24CAMK1D1.44474658
25LATS21.42919356
26JAK11.33726996
27IRAK31.33522550
28PDGFRA1.32054153
29MAP3K141.30991248
30JAK31.26353043
31MAP4K11.26058928
32DMPK1.25297373
33LRRK21.24944872
34NEK91.24727868
35TAOK31.24309843
36LMTK21.21388857
37CSK1.19945493
38CDC42BPA1.13865791
39NME21.12571888
40BMX1.10404197
41SMG11.05376997
42EPHA31.01400762
43CDK81.01113102
44STK381.00607213
45LATS11.00524568
46KIT1.00134957
47JAK20.99104231
48TRPM70.98056301
49PAK40.96807877
50IKBKE0.95587405
51FLT30.95534307
52STK100.95111368
53TGFBR10.93174537
54ARAF0.92624300
55MAP3K110.92314977
56DDR20.90785065
57FGFR30.87855073
58PRKG20.86465632
59ROCK20.85620513
60FER0.84160072
61PTK20.83605583
62EPHB20.82897952
63ZAP700.81862289
64MAP3K100.80072805
65MOS0.78637944
66MET0.78263487
67PRKAA20.77644627
68CAMK1G0.77387531
69PDK20.74686880
70MATK0.74192900
71ROCK10.73266393
72GSK3A0.72219520
73MAP3K70.71307755
74PRKD20.71282942
75CDK60.67778143
76PRPF4B0.67739644
77MAPKAPK30.67252839
78RPS6KA20.66662349
79ABL20.65611710
80PDK40.65277776
81PDK30.65277776
82BLK0.64728383
83PRKD10.63993926
84MAP3K60.62476458
85PIM20.62414580
86OBSCN0.61606109
87PIK3CG0.61588661
88TESK20.61024772
89PTK2B0.60993003
90PIK3CA0.60759258
91EEF2K0.60456125
92MAP3K120.60372042
93PAK20.60035844
94IKBKB0.58999539
95RPS6KA40.58830185
96CHUK0.58694410
97EGFR0.58646201
98PDGFRB0.58152187
99MAP2K20.57375465
100MAPK110.57284924
101SCYL20.56815361
102FGR0.54819291
103MAP3K20.54496681
104STK30.54084329
105PDPK10.53059818
106CAMK2G0.52991679
107MAP3K10.52493389
108STK240.51874124
109MTOR0.51343998
110ERBB40.49654634
111MAP2K10.48806384
112TAOK20.47819599
113ICK0.47814045
114PHKG10.47682560
115PHKG20.47682560
116RET0.47621501
117MELK0.46455549
118ILK0.46394045
119DAPK30.45955794
120MAP3K80.45481946
121RPS6KA60.44889254
122MAPK120.44769486
123HCK0.44075127
124CAMK2D0.42600162
125MAP3K130.41510207
126RPS6KL10.40456092
127RPS6KC10.40456092
128MAPK40.38792169
129PAK10.36715393
130HIPK20.36073578
131GRK70.34035215
132CDK90.33685547
133* SRC0.33486296
134MARK20.32975593
135MAPKAPK20.32612799
136CAMK2B0.32507503
137MST40.28335711
138KSR20.26796709
139MAPK70.25323075
140MAP3K90.22830204
141ADRBK10.18851002
142CLK10.18835996
143KSR10.17774438
144AKT20.17561604

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.69392629
2Staphylococcus aureus infection_Homo sapiens_hsa051502.68818384
3Nitrogen metabolism_Homo sapiens_hsa009102.66630775
4Fatty acid degradation_Homo sapiens_hsa000712.56356565
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55460329
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.37851589
7Arginine biosynthesis_Homo sapiens_hsa002202.36853059
8PPAR signaling pathway_Homo sapiens_hsa033202.22789122
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.16304017
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14016073
11Caffeine metabolism_Homo sapiens_hsa002322.08299474
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04920838
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98503793
14Propanoate metabolism_Homo sapiens_hsa006401.92525727
15Fatty acid metabolism_Homo sapiens_hsa012121.90413779
16Tryptophan metabolism_Homo sapiens_hsa003801.81634709
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68302349
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65646981
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59731327
20Bladder cancer_Homo sapiens_hsa052191.51722517
21Regulation of actin cytoskeleton_Homo sapiens_hsa048101.50414279
22beta-Alanine metabolism_Homo sapiens_hsa004101.42200793
23Malaria_Homo sapiens_hsa051441.37574912
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35914430
25Prion diseases_Homo sapiens_hsa050201.35513581
26Peroxisome_Homo sapiens_hsa041461.29729511
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28813723
28Carbon metabolism_Homo sapiens_hsa012001.28368385
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27992334
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.27425552
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.24092370
32Starch and sucrose metabolism_Homo sapiens_hsa005001.23732352
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21942594
34Leishmaniasis_Homo sapiens_hsa051401.21835071
35Pancreatic cancer_Homo sapiens_hsa052121.21447251
36Tight junction_Homo sapiens_hsa045301.21385002
37Histidine metabolism_Homo sapiens_hsa003401.21019432
38Bile secretion_Homo sapiens_hsa049761.14684417
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.14203890
40Chemical carcinogenesis_Homo sapiens_hsa052041.14075513
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13652451
42Vibrio cholerae infection_Homo sapiens_hsa051101.11450067
43Pyruvate metabolism_Homo sapiens_hsa006201.10472217
44Phenylalanine metabolism_Homo sapiens_hsa003601.09469729
45ECM-receptor interaction_Homo sapiens_hsa045121.07019175
46Fat digestion and absorption_Homo sapiens_hsa049751.06710184
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06171365
48N-Glycan biosynthesis_Homo sapiens_hsa005101.06009763
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05916376
50Insulin resistance_Homo sapiens_hsa049311.03703067
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00988636
52Osteoclast differentiation_Homo sapiens_hsa043800.99864453
53Butanoate metabolism_Homo sapiens_hsa006500.99566958
54Fatty acid biosynthesis_Homo sapiens_hsa000610.99225438
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98336172
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97826798
57Protein digestion and absorption_Homo sapiens_hsa049740.97777765
58Pertussis_Homo sapiens_hsa051330.97476078
59ABC transporters_Homo sapiens_hsa020100.97097514
60Amoebiasis_Homo sapiens_hsa051460.96261549
61Shigellosis_Homo sapiens_hsa051310.93693512
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93356601
63Lysosome_Homo sapiens_hsa041420.92513097
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.91824869
65Renal cell carcinoma_Homo sapiens_hsa052110.89583644
66Focal adhesion_Homo sapiens_hsa045100.88988617
67Legionellosis_Homo sapiens_hsa051340.88914096
68Hippo signaling pathway_Homo sapiens_hsa043900.88558694
69Selenocompound metabolism_Homo sapiens_hsa004500.87617394
70Dilated cardiomyopathy_Homo sapiens_hsa054140.86314804
71Toxoplasmosis_Homo sapiens_hsa051450.85972105
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83354859
73Biosynthesis of amino acids_Homo sapiens_hsa012300.83179047
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82286674
75Notch signaling pathway_Homo sapiens_hsa043300.81488862
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81346507
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81340598
78Glycerolipid metabolism_Homo sapiens_hsa005610.80937416
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80558293
80Endocytosis_Homo sapiens_hsa041440.80137096
81Pathways in cancer_Homo sapiens_hsa052000.78790577
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.78507811
83Retinol metabolism_Homo sapiens_hsa008300.78068697
84Lysine degradation_Homo sapiens_hsa003100.76988021
85TNF signaling pathway_Homo sapiens_hsa046680.74596294
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73588437
87Arginine and proline metabolism_Homo sapiens_hsa003300.73099651
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71456980
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.71423343
90Sphingolipid metabolism_Homo sapiens_hsa006000.70299622
91MicroRNAs in cancer_Homo sapiens_hsa052060.69544766
92Pentose phosphate pathway_Homo sapiens_hsa000300.68235424
93Viral myocarditis_Homo sapiens_hsa054160.68116535
94Tuberculosis_Homo sapiens_hsa051520.66264942
95TGF-beta signaling pathway_Homo sapiens_hsa043500.66257497
96Rap1 signaling pathway_Homo sapiens_hsa040150.66018991
97Axon guidance_Homo sapiens_hsa043600.65574514
98Vitamin digestion and absorption_Homo sapiens_hsa049770.65140272
99Small cell lung cancer_Homo sapiens_hsa052220.64161128
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63950731
101Thyroid cancer_Homo sapiens_hsa052160.63834599
102Glutathione metabolism_Homo sapiens_hsa004800.62778945
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59761557
104Mineral absorption_Homo sapiens_hsa049780.59760504
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57720665
106Tyrosine metabolism_Homo sapiens_hsa003500.57687241
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.57115735
108Proteoglycans in cancer_Homo sapiens_hsa052050.57057788
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55912350
110VEGF signaling pathway_Homo sapiens_hsa043700.54997905
111Fatty acid elongation_Homo sapiens_hsa000620.54852088
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54334434
113Adherens junction_Homo sapiens_hsa045200.52748427
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.52452284
115Glioma_Homo sapiens_hsa052140.50939028
116Other glycan degradation_Homo sapiens_hsa005110.50401381
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49892698
118Salmonella infection_Homo sapiens_hsa051320.49267261
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48388320
120Gap junction_Homo sapiens_hsa045400.48142339
121Insulin signaling pathway_Homo sapiens_hsa049100.47532573
122Hepatitis C_Homo sapiens_hsa051600.46642766
123HIF-1 signaling pathway_Homo sapiens_hsa040660.46635649
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46558098
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46423526
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.46089941
127Melanoma_Homo sapiens_hsa052180.44953698
128Phagosome_Homo sapiens_hsa041450.44639250
129Apoptosis_Homo sapiens_hsa042100.44584053
130GnRH signaling pathway_Homo sapiens_hsa049120.44053874
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44023480
132Thyroid hormone synthesis_Homo sapiens_hsa049180.43736360
133Platelet activation_Homo sapiens_hsa046110.43687759
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43649239
135African trypanosomiasis_Homo sapiens_hsa051430.43483881
136AMPK signaling pathway_Homo sapiens_hsa041520.43228202
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42810380
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.42304777
139Influenza A_Homo sapiens_hsa051640.41383841
140Galactose metabolism_Homo sapiens_hsa000520.40899634
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.40596889
142Chronic myeloid leukemia_Homo sapiens_hsa052200.40160372
143Sulfur metabolism_Homo sapiens_hsa009200.39525879
144Fructose and mannose metabolism_Homo sapiens_hsa000510.39153408
145Renin-angiotensin system_Homo sapiens_hsa046140.36566210

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