TGM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1artery development (GO:0060840)9.18305787
2prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060529.13975380
3regulation of microtubule-based movement (GO:0060632)9.07784071
4regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)8.79419740
5L-fucose catabolic process (GO:0042355)8.11502027
6fucose catabolic process (GO:0019317)8.11502027
7L-fucose metabolic process (GO:0042354)8.11502027
8prostate gland epithelium morphogenesis (GO:0060740)8.11068847
9mitotic cell cycle arrest (GO:0071850)7.43409492
10mannose metabolic process (GO:0006013)7.28450593
11sperm motility (GO:0030317)7.09569209
12positive regulation of steroid hormone secretion (GO:2000833)7.00026325
13regulation of receptor binding (GO:1900120)6.87407334
14adenosine metabolic process (GO:0046085)6.76218803
15Golgi transport vesicle coating (GO:0048200)6.75162430
16COPI coating of Golgi vesicle (GO:0048205)6.75162430
17response to testosterone (GO:0033574)6.70628215
18ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)6.58251151
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.43627844
20intermediate filament organization (GO:0045109)6.29310806
21fucose metabolic process (GO:0006004)6.02703951
22valine metabolic process (GO:0006573)6.01098320
23galactose catabolic process (GO:0019388)5.94605651
24regulation of sensory perception (GO:0051931)5.89600528
25regulation of sensory perception of pain (GO:0051930)5.89600528
26epithelial cell differentiation involved in prostate gland development (GO:0060742)5.89557382
27acrosome reaction (GO:0007340)5.87268275
28positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)5.84204632
29N-glycan processing (GO:0006491)5.82131659
30activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.79339640
31positive regulation of nuclease activity (GO:0032075)5.53995819
32axon development (GO:0061564)5.46910224
33fusion of sperm to egg plasma membrane (GO:0007342)5.35529891
34positive regulation of growth hormone secretion (GO:0060124)5.30021673
35epithelial cell maturation (GO:0002070)5.29007700
36pharyngeal system development (GO:0060037)5.25813377
37activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)5.19361926
38regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)5.14212165
39multicellular organism reproduction (GO:0032504)5.08922577
40regulation of nuclease activity (GO:0032069)5.03309920
41positive regulation of chemokine secretion (GO:0090197)5.03210988
42sperm capacitation (GO:0048240)5.01464854
43chromosome condensation (GO:0030261)4.91620308
44endoplasmic reticulum unfolded protein response (GO:0030968)4.87437272
45lung secretory cell differentiation (GO:0061140)4.87207266
46DNA packaging (GO:0006323)4.85451092
47protein retention in ER lumen (GO:0006621)4.85124105
48hormone catabolic process (GO:0042447)4.83064106
49intestinal epithelial cell development (GO:0060576)4.75114411
50adaptation of signaling pathway (GO:0023058)4.74471414
51cellular response to unfolded protein (GO:0034620)4.71913953
52regulation of steroid hormone secretion (GO:2000831)4.68872929
53linoleic acid metabolic process (GO:0043651)4.66174626
54reproduction (GO:0000003)4.63286882
55UDP-N-acetylglucosamine metabolic process (GO:0006047)4.62228566
56positive regulation of natural killer cell differentiation (GO:0032825)4.51964857
57ER-nucleus signaling pathway (GO:0006984)4.49001800
58potassium ion homeostasis (GO:0055075)4.46378763
59response to endoplasmic reticulum stress (GO:0034976)4.44200521
60spermatid nucleus differentiation (GO:0007289)4.42929728
61spermatid development (GO:0007286)4.40680912
62polyamine biosynthetic process (GO:0006596)4.38052681
63cellular response to topologically incorrect protein (GO:0035967)4.37766686
64regulation of chemokine secretion (GO:0090196)4.36782498
65pyrimidine-containing compound transmembrane transport (GO:0072531)4.22395212
66fucosylation (GO:0036065)4.18387830
67regulation of growth hormone secretion (GO:0060123)4.16675938
68fructose metabolic process (GO:0006000)4.14579424
69COPII vesicle coating (GO:0048208)4.12676130
70intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)4.12537049
71response to acidic pH (GO:0010447)4.09982407
72apoptotic cell clearance (GO:0043277)4.07483788
73sexual reproduction (GO:0019953)4.06118966
74negative regulation of inclusion body assembly (GO:0090084)4.05056317
75retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.04296438
76regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.00412239
77positive regulation of catenin import into nucleus (GO:0035413)3.96037068
78positive regulation of action potential (GO:0045760)3.95641114
79plasma membrane fusion (GO:0045026)3.91110882
80cellular response to pH (GO:0071467)3.90692044
81positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.90456134
82positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.90139287
83protein N-linked glycosylation via asparagine (GO:0018279)3.88946294
84angiotensin maturation (GO:0002003)3.88081954
852-oxoglutarate metabolic process (GO:0006103)3.87391533
86peptidyl-asparagine modification (GO:0018196)3.86936467
87glandular epithelial cell differentiation (GO:0002067)3.86926261
88protein autoprocessing (GO:0016540)3.86912093
89vitamin transmembrane transport (GO:0035461)3.86384532
90iron ion import (GO:0097286)3.86376028
91regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.85996437
92hexose catabolic process (GO:0019320)3.84996088
93positive regulation of keratinocyte differentiation (GO:0045618)3.83459869
94GDP-mannose metabolic process (GO:0019673)3.80944755
95regulation of viral entry into host cell (GO:0046596)3.80125519
96sperm-egg recognition (GO:0035036)3.76552421
97positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.75098520
98phosphatidylethanolamine biosynthetic process (GO:0006646)3.71389534
99ER overload response (GO:0006983)3.71257949
100response to unfolded protein (GO:0006986)3.67759396
101organic cation transport (GO:0015695)3.65526915
102microtubule severing (GO:0051013)3.65343762
103negative regulation of cholesterol transport (GO:0032375)3.63073104
104negative regulation of sterol transport (GO:0032372)3.63073104
105lung lobe morphogenesis (GO:0060463)3.61673496
106protein N-linked glycosylation (GO:0006487)3.55216057
107cellular modified amino acid catabolic process (GO:0042219)3.52618267
108nucleotide-sugar biosynthetic process (GO:0009226)3.51387891
109binding of sperm to zona pellucida (GO:0007339)3.51120793
110galactose metabolic process (GO:0006012)3.50940598
111cellular ketone body metabolic process (GO:0046950)3.50480603
112sulfur amino acid catabolic process (GO:0000098)3.47450064
113protein kinase B signaling (GO:0043491)3.46440726
114intermediate filament cytoskeleton organization (GO:0045104)3.45536358
115branched-chain amino acid metabolic process (GO:0009081)3.45185544
116hypotonic response (GO:0006971)3.45020071
117response to topologically incorrect protein (GO:0035966)3.44821266
118face development (GO:0060324)3.44817516
119protein targeting to Golgi (GO:0000042)3.44085246
120phosphatidylethanolamine metabolic process (GO:0046337)3.42383073
121vesicle coating (GO:0006901)3.42262160
122long-chain fatty acid biosynthetic process (GO:0042759)3.41521882
123oxaloacetate metabolic process (GO:0006107)3.40998805
124sequestering of metal ion (GO:0051238)3.35889630
125phospholipid scrambling (GO:0017121)3.33798206
126insulin-like growth factor receptor signaling pathway (GO:0048009)3.32926453
127intermediate filament-based process (GO:0045103)3.32262532
128zinc ion transport (GO:0006829)3.29035714
129nucleotide-sugar metabolic process (GO:0009225)3.28924232
130fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.28835958
131regulation of protein glycosylation (GO:0060049)3.27987010
132single strand break repair (GO:0000012)3.27102140
133mammary gland alveolus development (GO:0060749)3.25085981
134lipoxygenase pathway (GO:0019372)3.22396178
135endothelial cell chemotaxis (GO:0035767)3.21098480
136extracellular matrix assembly (GO:0085029)3.19757910
137negative regulation of erythrocyte differentiation (GO:0045647)3.19736434
138glycerophospholipid catabolic process (GO:0046475)3.14236632
139calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.13560206
140calcium ion-dependent exocytosis (GO:0017156)3.12946190
141monosaccharide catabolic process (GO:0046365)3.12483927
142establishment of protein localization to Golgi (GO:0072600)3.10006433
143single fertilization (GO:0007338)3.08689435
144retrograde transport, vesicle recycling within Golgi (GO:0000301)3.07212082
145one-carbon compound transport (GO:0019755)3.06128350
146polyol catabolic process (GO:0046174)3.04713099
147ketone body metabolic process (GO:1902224)3.03013156
148beta-amyloid metabolic process (GO:0050435)3.01142449
149defense response to Gram-negative bacterium (GO:0050829)3.00623320
150spermatogenesis (GO:0007283)3.00294235
151male gamete generation (GO:0048232)2.98568007
152lung cell differentiation (GO:0060479)2.98469087
153lung epithelial cell differentiation (GO:0060487)2.96827838
154transcytosis (GO:0045056)2.95494613
155macroautophagy (GO:0016236)2.93402441
156retinal metabolic process (GO:0042574)2.93389961
157cell-cell recognition (GO:0009988)2.91976313
158plasma membrane repair (GO:0001778)2.91322757
159cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.90237439
160creatine metabolic process (GO:0006600)2.89546398
161regulation of neurological system process (GO:0031644)2.88825739
162import into cell (GO:0098657)2.88546298
163positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.87969916
164L-serine transport (GO:0015825)2.87820634
165peptide catabolic process (GO:0043171)2.87519673
166detection of temperature stimulus (GO:0016048)2.87042564
167glucosamine-containing compound catabolic process (GO:1901072)2.82608881
168negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.81092488
169negative regulation of Rho protein signal transduction (GO:0035024)2.79780977
170rRNA methylation (GO:0031167)2.78496561
171response to pheromone (GO:0019236)2.78478602
172protein polyglutamylation (GO:0018095)2.78327173
173negative regulation of stress fiber assembly (GO:0051497)2.76493668
174gamete generation (GO:0007276)2.75551668
175cytoskeletal anchoring at plasma membrane (GO:0007016)2.74179277
176growth hormone secretion (GO:0030252)2.74002890
177sequestering of extracellular ligand from receptor (GO:0035581)2.73221915
178toxin transport (GO:1901998)2.71252708
179nucleus organization (GO:0006997)2.69937212
180tonic smooth muscle contraction (GO:0014820)2.69206473
181branching involved in prostate gland morphogenesis (GO:0060442)12.8647533
182neurofilament cytoskeleton organization (GO:0060052)11.4572550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63704375
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.50263991
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.37664796
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.35866410
5ZNF263_19887448_ChIP-Seq_K562_Human3.30788494
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.20750439
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.20750439
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.20750439
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.92755638
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.89533155
11* AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.82022692
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76737337
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.62971326
14CLOCK_20551151_ChIP-Seq_293T_Human2.59306056
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53829110
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.49141632
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.47717104
18ZNF217_24962896_ChIP-Seq_MCF-7_Human2.44900892
19* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.43311040
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31893212
21SOX2_20726797_ChIP-Seq_SW620_Human2.31833058
22FOXO3_23340844_ChIP-Seq_DLD1_Human2.13758795
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.11560187
24AHR_22903824_ChIP-Seq_MCF-7_Human2.10770985
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.02007913
26AR_21572438_ChIP-Seq_LNCaP_Human2.01999116
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95929942
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.91062521
29GATA6_25053715_ChIP-Seq_YYC3_Human1.87853521
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.87812229
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85622210
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.85051727
33CHD1_26751641_Chip-Seq_LNCaP_Human1.83388587
34EZH2_22144423_ChIP-Seq_EOC_Human1.82737698
35GATA1_22025678_ChIP-Seq_K562_Human1.81572362
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80342511
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77585465
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75998190
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75998190
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.71654802
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71633788
42FOXA1_25552417_ChIP-Seq_VCAP_Human1.70023945
43GATA4_25053715_ChIP-Seq_YYC3_Human1.69947085
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67958854
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.67687015
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66579144
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64282294
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.62108818
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61716649
50RXR_22158963_ChIP-Seq_LIVER_Mouse1.59142752
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.57935096
52GATA3_24758297_ChIP-Seq_MCF-7_Human1.56909621
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55364680
54ZNF274_21170338_ChIP-Seq_K562_Hela1.54802745
55DROSHA_22980978_ChIP-Seq_HELA_Human1.54246848
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51446651
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48718889
58FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.48685033
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.47824497
60VDR_24787735_ChIP-Seq_THP-1_Human1.47744990
61AR_21909140_ChIP-Seq_LNCAP_Human1.45047458
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44104767
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42401382
64LXR_22292898_ChIP-Seq_THP-1_Human1.41519290
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.40814743
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.40758606
67* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38790463
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38365714
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38250110
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36848211
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36848211
72ELF5_23300383_ChIP-Seq_T47D_Human1.36744034
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35490262
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35452084
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34398022
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32121280
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31919796
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.31681285
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31507949
80* CREB1_26743006_Chip-Seq_LNCaP_Human1.31406059
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30753749
82SMRT_27268052_Chip-Seq_Bcells_Human1.30219891
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28779235
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.28728237
85TP53_22127205_ChIP-Seq_IMR90_Human1.28292341
86ATF3_27146783_Chip-Seq_COLON_Human1.22770984
87IRF1_19129219_ChIP-ChIP_H3396_Human1.21945426
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21260255
89AR_25329375_ChIP-Seq_VCAP_Human1.20631983
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.20075246
91IGF1R_20145208_ChIP-Seq_DFB_Human1.19680952
92KLF5_25053715_ChIP-Seq_YYC3_Human1.16799144
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.16641858
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15845366
95STAT1_20625510_ChIP-Seq_HELA_Human1.15725346
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14794379
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.14599586
98SMC4_20622854_ChIP-Seq_HELA_Human1.13457735
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12817650
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.11786916
101RACK7_27058665_Chip-Seq_MCF-7_Human1.11183991
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.10351836
103* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09506176
104FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08318472
105NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.07935406
106* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07907171
107ERA_21632823_ChIP-Seq_H3396_Human1.07625125
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05028603
109TCF7_22412390_ChIP-Seq_EML_Mouse1.04966703
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04449181
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03807722
112CTCF_27219007_Chip-Seq_Bcells_Human1.01957790
113GATA1_19941826_ChIP-Seq_K562_Human1.01761381
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01705575
115TP53_16413492_ChIP-PET_HCT116_Human1.01049371
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00983992
117PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00953123
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98697611
119SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98581878
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98045639
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97593073
122MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96552144
123* TP63_22573176_ChIP-Seq_HFKS_Human0.95066560
124P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.94594141
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93865836
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92561283
127ERG_20517297_ChIP-Seq_VCAP_Human0.91319043
128MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.91255768
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91026187
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.90875148
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90875062
132OCT1_27270436_Chip-Seq_PROSTATE_Human0.90561560
133MYC_22102868_ChIP-Seq_BL_Human0.90539151
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.90254965
135SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90221894
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90157343
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89454370
138RXR_22108803_ChIP-Seq_LS180_Human0.88810761
139* OCT4_20526341_ChIP-Seq_ESCs_Human0.88783774
140SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88730545
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88574736
142ISL1_27105846_Chip-Seq_CPCs_Mouse0.87353975
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87309508
144CTCF_20526341_ChIP-Seq_ESCs_Human0.86622941
145RUNX2_22187159_ChIP-Seq_PCA_Human0.86557133
146* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86367773
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.85837267
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84984643
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84984643
150GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84768528
151RING1B_27294783_Chip-Seq_NPCs_Mouse0.84598591
152EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84074724
153FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83878357
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83451561
155RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82549033
156BCOR_27268052_Chip-Seq_Bcells_Human0.81697915
157SMAD4_21799915_ChIP-Seq_A2780_Human0.81606898
158CEBPB_22108803_ChIP-Seq_LS180_Human0.81497130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.60082651
2MP0003011_delayed_dark_adaptation6.52444747
3MP0005310_abnormal_salivary_gland5.91217986
4MP0003300_gastrointestinal_ulcer5.77396087
5MP0002166_altered_tumor_susceptibility5.50130061
6MP0010234_abnormal_vibrissa_follicle4.90306585
7MP0005647_abnormal_sex_gland4.60009146
8MP0004043_abnormal_pH_regulation4.52383512
9MP0005670_abnormal_white_adipose4.11399321
10MP0002006_tumorigenesis4.01838170
11MP0000613_abnormal_salivary_gland3.37944689
12MP0010386_abnormal_urinary_bladder3.30013243
13MP0004510_myositis3.13376742
14MP0001765_abnormal_ion_homeostasis2.69503431
15MP0004858_abnormal_nervous_system2.66559343
16MP0000537_abnormal_urethra_morphology2.64917732
17MP0001873_stomach_inflammation2.48053478
18MP0002132_abnormal_respiratory_system2.46929919
19MP0002736_abnormal_nociception_after2.45675821
20MP0001756_abnormal_urination2.44007527
21MP0002234_abnormal_pharynx_morphology2.43047204
22MP0003698_abnormal_male_reproductive2.41088594
23MP0009764_decreased_sensitivity_to2.40585440
24MP0002822_catalepsy2.21060804
25MP0001968_abnormal_touch/_nociception2.15368407
26MP0002139_abnormal_hepatobiliary_system2.12482026
27MP0003656_abnormal_erythrocyte_physiolo2.08249676
28MP0003183_abnormal_peptide_metabolism2.07702863
29MP0001929_abnormal_gametogenesis1.90205709
30MP0005636_abnormal_mineral_homeostasis1.84064839
31MP0004264_abnormal_extraembryonic_tissu1.83446411
32MP0003866_abnormal_defecation1.76551544
33MP0009765_abnormal_xenobiotic_induced1.76019324
34MP0009780_abnormal_chondrocyte_physiolo1.70964652
35MP0005058_abnormal_lysosome_morphology1.70394239
36MP0010352_gastrointestinal_tract_polyps1.67254677
37MP0002009_preneoplasia1.63081525
38MP0002295_abnormal_pulmonary_circulatio1.62481160
39MP0000678_abnormal_parathyroid_gland1.50024127
40MP0005332_abnormal_amino_acid1.48673404
41MP0009643_abnormal_urine_homeostasis1.46733317
42MP0005166_decreased_susceptibility_to1.46311794
43MP0005220_abnormal_exocrine_pancreas1.45979316
44MP0002163_abnormal_gland_morphology1.41077177
45MP0002161_abnormal_fertility/fecundity1.40528107
46MP0005379_endocrine/exocrine_gland_phen1.38797394
47MP0001958_emphysema1.37730039
48MP0000538_abnormal_urinary_bladder1.36223602
49MP0000013_abnormal_adipose_tissue1.35099508
50MP0003879_abnormal_hair_cell1.34246751
51MP0004036_abnormal_muscle_relaxation1.30174883
52MP0001299_abnormal_eye_distance/1.28026585
53MP0010155_abnormal_intestine_physiology1.27203569
54MP0005646_abnormal_pituitary_gland1.26550755
55MP0003718_maternal_effect1.24111943
56MP0002136_abnormal_kidney_physiology1.23072766
57MP0005409_darkened_coat_color1.21754058
58MP0003705_abnormal_hypodermis_morpholog1.19827281
59MP0000534_abnormal_ureter_morphology1.17260756
60MP0001764_abnormal_homeostasis1.16424900
61MP0002876_abnormal_thyroid_physiology1.14842889
62MP0004134_abnormal_chest_morphology1.14307646
63MP0000653_abnormal_sex_gland1.11218624
64MP0005377_hearing/vestibular/ear_phenot1.09497537
65MP0003878_abnormal_ear_physiology1.09497537
66MP0005248_abnormal_Harderian_gland1.07955185
67MP0001145_abnormal_male_reproductive1.07259028
68MP0010678_abnormal_skin_adnexa1.06853214
69MP0002735_abnormal_chemical_nociception1.03618959
70MP0006054_spinal_hemorrhage1.03396691
71MP0005023_abnormal_wound_healing1.03191598
72MP0003942_abnormal_urinary_system1.02003181
73MP0000343_altered_response_to1.01528604
74MP0002909_abnormal_adrenal_gland1.01135566
75MP0002396_abnormal_hematopoietic_system1.00647988
76MP0005395_other_phenotype0.98607898
77MP0002249_abnormal_larynx_morphology0.96457659
78MP0005375_adipose_tissue_phenotype0.94001177
79MP0003045_fibrosis0.93355633
80MP0008438_abnormal_cutaneous_collagen0.92294738
81MP0000955_abnormal_spinal_cord0.92246253
82MP0003315_abnormal_perineum_morphology0.92167143
83MP0002115_abnormal_skeleton_extremities0.91937104
84MP0008875_abnormal_xenobiotic_pharmacok0.91856894
85MP0001879_abnormal_lymphatic_vessel0.91083005
86MP0002837_dystrophic_cardiac_calcinosis0.90915841
87MP0000003_abnormal_adipose_tissue0.88817902
88MP0004947_skin_inflammation0.87918858
89MP0003638_abnormal_response/metabolism_0.86881419
90MP0005666_abnormal_adipose_tissue0.86326410
91MP0003186_abnormal_redox_activity0.86252196
92MP0000230_abnormal_systemic_arterial0.86068571
93MP0005187_abnormal_penis_morphology0.85954386
94MP0005319_abnormal_enzyme/_coenzyme0.85421214
95MP0002135_abnormal_kidney_morphology0.83356391
96MP0009384_cardiac_valve_regurgitation0.83239013
97MP0003137_abnormal_impulse_conducting0.83162282
98MP0005076_abnormal_cell_differentiation0.82956739
99MP0001346_abnormal_lacrimal_gland0.82363745
100MP0002168_other_aberrant_phenotype0.81034997
101MP0001944_abnormal_pancreas_morphology0.79198955
102MP0002210_abnormal_sex_determination0.78638769
103MP0002111_abnormal_tail_morphology0.78543593
104MP0001348_abnormal_lacrimal_gland0.78492246
105MP0000767_abnormal_smooth_muscle0.78156009
106MP0001666_abnormal_nutrient_absorption0.77779927
107MP0000627_abnormal_mammary_gland0.77360161
108MP0004145_abnormal_muscle_electrophysio0.75973217
109MP0000516_abnormal_urinary_system0.75727189
110MP0005367_renal/urinary_system_phenotyp0.75727189
111MP0003890_abnormal_embryonic-extraembry0.73411659
112MP0000477_abnormal_intestine_morphology0.72358724
113MP0005381_digestive/alimentary_phenotyp0.72084499
114MP0001663_abnormal_digestive_system0.70346110
115MP0000163_abnormal_cartilage_morphology0.70299021
116MP0003566_abnormal_cell_adhesion0.69240826
117MP0005167_abnormal_blood-brain_barrier0.68216484
118MP0002229_neurodegeneration0.67105806
119MP0005330_cardiomyopathy0.66829141
120MP0002184_abnormal_innervation0.66540405
121MP0000490_abnormal_crypts_of0.65962214
122MP0000681_abnormal_thyroid_gland0.65662635
123MP0008961_abnormal_basal_metabolism0.64083656
124MP0003868_abnormal_feces_composition0.63865427
125MP0002896_abnormal_bone_mineralization0.62061539
126MP0001270_distended_abdomen0.61701623
127MP0003936_abnormal_reproductive_system0.60232448
128MP0005253_abnormal_eye_physiology0.58600055
129MP0005275_abnormal_skin_tensile0.58122262
130MP0001664_abnormal_digestion0.58036614
131MP0000470_abnormal_stomach_morphology0.57913137
132MP0002109_abnormal_limb_morphology0.56610441
133MP0000566_synostosis0.56461426
134MP0003959_abnormal_lean_body0.56454011
135MP0005365_abnormal_bile_salt0.56149382
136MP0003699_abnormal_female_reproductive0.55583210
137MP0003075_altered_response_to0.55175194
138MP0004085_abnormal_heartbeat0.55107308
139MP0001845_abnormal_inflammatory_respons0.54209844
140MP0002796_impaired_skin_barrier0.54128604
141MP0002557_abnormal_social/conspecific_i0.53478809
142MP0004782_abnormal_surfactant_physiolog0.53419799
143MP0005595_abnormal_vascular_smooth0.52755475
144MP0005620_abnormal_muscle_contractility0.51860931
145MP0002272_abnormal_nervous_system0.51308991
146MP0001919_abnormal_reproductive_system0.50630576
147MP0000750_abnormal_muscle_regeneration0.50494751
148MP0004185_abnormal_adipocyte_glucose0.49870540
149MP0004019_abnormal_vitamin_homeostasis0.48658949
150MP0002127_abnormal_cardiovascular_syste0.48363048
151MP0000462_abnormal_digestive_system0.48250963
152MP0005551_abnormal_eye_electrophysiolog0.47403141
153MP0003091_abnormal_cell_migration0.47076625
154MP0002098_abnormal_vibrissa_morphology0.45408329
155MP0000609_abnormal_liver_physiology0.42947904
156MP0005408_hypopigmentation0.42912838
157MP0000747_muscle_weakness0.42885358
158MP0004147_increased_porphyrin_level0.42707528
159MP0005164_abnormal_response_to0.41231880

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)9.92188744
2Neoplasm of the heart (HP:0100544)8.03628661
3Malnutrition (HP:0004395)7.43124121
4Morphological abnormality of the inner ear (HP:0011390)6.91382190
5Amelogenesis imperfecta (HP:0000705)5.89839138
6Abnormality of abdominal situs (HP:0011620)5.01558489
7Abdominal situs inversus (HP:0003363)5.01558489
8Vacuolated lymphocytes (HP:0001922)4.65663209
9Abnormality of the intrinsic pathway (HP:0010989)4.36832294
10Aortic aneurysm (HP:0004942)4.25707386
11Potter facies (HP:0002009)4.05369822
12Facial shape deformation (HP:0011334)4.05369822
13Hyperkalemia (HP:0002153)3.75071238
14Hyperglycinuria (HP:0003108)3.62482422
15Severe visual impairment (HP:0001141)3.54282626
16Abnormality of secondary sexual hair (HP:0009888)3.46296773
17Abnormality of the axillary hair (HP:0100134)3.46296773
18Subcapsular cataract (HP:0000523)3.41697505
19Broad face (HP:0000283)3.36025211
20Hypoplasia of the pons (HP:0012110)3.35087905
21Hypomagnesemia (HP:0002917)3.29622653
22Gastrointestinal dysmotility (HP:0002579)3.25257398
23Hyperparathyroidism (HP:0000843)3.11000831
24Widely patent fontanelles and sutures (HP:0004492)3.03865444
25Achilles tendon contracture (HP:0001771)3.03396818
26Dysostosis multiplex (HP:0000943)3.03003428
27Abnormality of the pons (HP:0007361)2.98204879
28Abnormality of the phalanges of the hallux (HP:0010057)2.93880159
29Rectal prolapse (HP:0002035)2.93107217
30Abnormality of glycine metabolism (HP:0010895)2.91652019
31Abnormality of serine family amino acid metabolism (HP:0010894)2.91652019
32Sparse lateral eyebrow (HP:0005338)2.91325539
33Urinary glycosaminoglycan excretion (HP:0003541)2.83534786
34Mucopolysacchariduria (HP:0008155)2.83534786
35Abnormal foot bone ossification (HP:0010675)2.82717355
36Aortic dissection (HP:0002647)2.82508708
37Aplastic anemia (HP:0001915)2.81884676
38Abnormality of the Achilles tendon (HP:0005109)2.81621763
39Abnormal ossification of hand bones (HP:0005921)2.79104455
40Aplasia involving bones of the extremities (HP:0009825)2.78367771
41Aplasia involving bones of the upper limbs (HP:0009823)2.78367771
42Aplasia of the phalanges of the hand (HP:0009802)2.78367771
43Hydroxyprolinuria (HP:0003080)2.78314747
44Abnormality of proline metabolism (HP:0010907)2.78314747
45Bundle branch block (HP:0011710)2.76778913
46Abnormality of the distal phalanx of the thumb (HP:0009617)2.76593384
47Hypoplastic nipples (HP:0002557)2.76275747
48Abnormality of magnesium homeostasis (HP:0004921)2.75592234
49Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.73406119
50Short 1st metacarpal (HP:0010034)2.73406119
51Abnormality of the 2nd finger (HP:0004100)2.72155427
52Male infertility (HP:0003251)2.67726032
53Azoospermia (HP:0000027)2.64844327
54Resting tremor (HP:0002322)2.64582016
55Hypoplasia of the uterus (HP:0000013)2.64241275
56Short phalanx of the thumb (HP:0009660)2.62767167
57Thrombocytosis (HP:0001894)2.60796708
58Flattened epiphyses (HP:0003071)2.59983474
59Abnormality of the parathyroid morphology (HP:0011766)2.58505340
60Abnormal hand bone ossification (HP:0010660)2.56992919
61Asymmetric septal hypertrophy (HP:0001670)2.55697084
62Shawl scrotum (HP:0000049)2.55606526
63Infertility (HP:0000789)2.53862705
64Abnormality of carpal bone ossification (HP:0006257)2.50297919
65Sensorimotor neuropathy (HP:0007141)2.49909616
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.48679050
67Abnormality of polysaccharide metabolism (HP:0011012)2.48679050
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.48679050
69Abnormality of the 1st metacarpal (HP:0010009)2.46682256
70Abnormality of the aortic arch (HP:0012303)2.46571723
71Hand muscle atrophy (HP:0009130)2.44983818
72Hydroureter (HP:0000072)2.38754062
73Right ventricular cardiomyopathy (HP:0011663)2.37738324
74Coxa valga (HP:0002673)2.36930071
75Bronchomalacia (HP:0002780)2.35289318
76Bicuspid aortic valve (HP:0001647)2.34526562
77Laryngomalacia (HP:0001601)2.33197654
78Truncal obesity (HP:0001956)2.31577640
79Aplasia of the musculature (HP:0100854)2.29440284
80Hypoplasia of the ulna (HP:0003022)2.28919777
81Ventricular tachycardia (HP:0004756)2.28721180
82Omphalocele (HP:0001539)2.26949979
83Epiphyseal dysplasia (HP:0002656)2.22610758
84Thoracolumbar scoliosis (HP:0002944)2.21658833
85Intention tremor (HP:0002080)2.18538698
86Degeneration of the lateral corticospinal tracts (HP:0002314)2.17733302
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17733302
88Biliary tract neoplasm (HP:0100574)2.17329211
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13591751
90Hyporeflexia of lower limbs (HP:0002600)2.13234268
91Hematochezia (HP:0002573)2.13158448
92Aneurysm (HP:0002617)2.13139862
93Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10955236
94Facial diplegia (HP:0001349)2.10540515
95Short hallux (HP:0010109)2.10210057
96Synostosis of carpal bones (HP:0005048)2.09822433
97Back pain (HP:0003418)2.09418512
98Polar cataract (HP:0010696)2.09351697
99Abnormal tarsal ossification (HP:0008369)2.07859575
100Intellectual disability, moderate (HP:0002342)2.07444721
101Barrel-shaped chest (HP:0001552)2.06149174
102Testicular atrophy (HP:0000029)2.05704619
103Papillary thyroid carcinoma (HP:0002895)2.04747730
104Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.04385243
105Abnormality of the ischium (HP:0003174)2.03650358
106Chronic hepatic failure (HP:0100626)2.01933465
107Cone-rod dystrophy (HP:0000548)2.01574984
108Myopathic facies (HP:0002058)2.01555683
109Exocrine pancreatic insufficiency (HP:0001738)2.00855246
110Abnormal spermatogenesis (HP:0008669)2.00676977
111Arterial tortuosity (HP:0005116)1.99693200
112Abnormality of the common coagulation pathway (HP:0010990)1.98562168
113Intrahepatic cholestasis (HP:0001406)1.98053122
114Flat acetabular roof (HP:0003180)1.97192986
115Reduced antithrombin III activity (HP:0001976)1.97009644
116Beaking of vertebral bodies (HP:0004568)1.96995435
117Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.96972260
118Anosmia (HP:0000458)1.96827300
119Aplasia/hypoplasia of the humerus (HP:0006507)1.96579628
120Septate vagina (HP:0001153)1.96299864
121Distal upper limb amyotrophy (HP:0007149)1.96122259
122Upper limb amyotrophy (HP:0009129)1.96122259
123Failure to thrive in infancy (HP:0001531)1.94893857
124Retinal atrophy (HP:0001105)1.94858871
125Abnormality of potassium homeostasis (HP:0011042)1.94844081
126Aplasia/Hypoplasia of the hallux (HP:0008362)1.94799222
127Status epilepticus (HP:0002133)1.94705585
128Wide cranial sutures (HP:0010537)1.94368651
129Pili torti (HP:0003777)1.94304737
130Shallow orbits (HP:0000586)1.94282534
131Distal arthrogryposis (HP:0005684)1.94158892
132Hydronephrosis (HP:0000126)1.93689128
133Tubulointerstitial nephritis (HP:0001970)1.90111504
134Myokymia (HP:0002411)1.89965744
135Obstructive sleep apnea (HP:0002870)1.88426077
136Hypoplastic scapulae (HP:0000882)1.88356812
137Aplasia/Hypoplasia of the scapulae (HP:0006713)1.88356812
138Stroke (HP:0001297)1.86397058
139Abnormality of the nasal septum (HP:0000419)1.85933035
140Bony spicule pigmentary retinopathy (HP:0007737)1.84484833
141Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.83976559
142Long toe (HP:0010511)1.82473277
143Lip pit (HP:0100267)1.82289259
144Progressive muscle weakness (HP:0003323)1.82231186
145Ulnar bowing (HP:0003031)1.81493632
146Short clavicles (HP:0000894)1.81088311
147Fibular aplasia (HP:0002990)1.81024038
148Vascular tortuosity (HP:0004948)1.80894650
149Short humerus (HP:0005792)1.80350721
150Abnormality of transition element cation homeostasis (HP:0011030)1.80055393
151Colon cancer (HP:0003003)1.79853192
152Attenuation of retinal blood vessels (HP:0007843)1.79637868
153Pulmonary artery stenosis (HP:0004415)1.78389820
154Radial bowing (HP:0002986)1.76833360
155Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76727428
156Persistence of primary teeth (HP:0006335)1.75762772
157Bulbar palsy (HP:0001283)1.75141732
158Abnormality of the fingertips (HP:0001211)1.74715630
159Hyperglycinemia (HP:0002154)1.73696431
160Abdominal distention (HP:0003270)1.73347658
161Abnormality of the proximal phalanges of the hand (HP:0009834)1.72402103
162Hypoplastic labia majora (HP:0000059)1.71844285
163Abnormality of chloride homeostasis (HP:0011422)1.71767581
164Centrally nucleated skeletal muscle fibers (HP:0003687)1.71350329
165Vertebral clefting (HP:0008428)1.70304742
166Aortic regurgitation (HP:0001659)1.69842585
167Syncope (HP:0001279)1.69529809
168Short nail (HP:0001799)1.69052826
169Advanced eruption of teeth (HP:0006288)1.68974631
170Menstrual irregularities (HP:0000858)1.64743195
171Germ cell neoplasia (HP:0100728)1.63863183
172Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63703797
173Skin pits (HP:0100276)1.62052764
174Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.60349935
175Abnormality of permanent molar morphology (HP:0011071)1.58575148
176Abnormality of the dental root (HP:0006486)1.58575148
177Taurodontia (HP:0000679)1.58575148
178Vesicoureteral reflux (HP:0000076)1.57566333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.26744462
2FRK5.38735353
3ERN15.08091856
4MST44.91262374
5TAOK34.16250907
6LATS13.46534418
7CAMK1G3.38414469
8EEF2K3.21007095
9CAMK1D3.12156999
10BCKDK2.90775919
11SCYL22.78994235
12SIK12.26020069
13MAPK152.24242634
14MAP3K22.06029575
15PRKD32.05658740
16MYLK1.93574320
17STK391.87502715
18CDK121.84470821
19MAPKAPK31.77817343
20TTN1.76892051
21EPHA21.69580763
22CDC42BPA1.62423446
23PDK21.53035212
24NUAK11.51153990
25LRRK21.48541090
26RPS6KB21.46247387
27LMTK21.43386273
28SGK4941.35693010
29SGK2231.35693010
30PNCK1.31606260
31STK38L1.26697030
32PLK41.26373046
33TESK21.14548918
34PTK61.13978421
35JAK31.13582344
36STK101.10468318
37TRIB31.04045848
38SGK21.01684176
39CAMK10.95537596
40SGK30.94285195
41PIK3CG0.94277001
42BRD40.91504531
43TNK20.91304574
44PIK3CA0.89356117
45DMPK0.85858630
46CSF1R0.78446787
47MARK20.76914867
48FER0.75934810
49RPS6KA20.72962923
50PDGFRA0.72533918
51STK30.70644737
52TESK10.68660371
53OXSR10.67448540
54EPHA30.67368751
55MET0.66906718
56CHUK0.65870176
57NEK60.65733490
58MST1R0.65179205
59JAK20.64614677
60PRKCI0.63435577
61ROCK20.63337417
62PAK20.62824183
63INSRR0.62172285
64PRKAA20.60458466
65ARAF0.58825871
66PKN20.57039785
67KSR20.56783270
68NTRK10.55401096
69MAP3K30.54992519
70MAPK10.54935568
71MAP3K130.53077553
72ACVR1B0.52669183
73MAP2K20.52575378
74TRPM70.52480357
75EIF2AK30.50605487
76JAK10.48905878
77FGFR20.48378516
78ROCK10.46716205
79DYRK1B0.46376450
80CAMK40.42598260
81MAP2K10.42552238
82NME10.42463906
83MAP3K80.41640402
84GSK3B0.41596761
85PDK10.40096059
86LATS20.39921316
87TYK20.38933204
88RIPK40.38434474
89PDPK10.37118824
90BRAF0.36730884
91SGK10.36400506
92GSK3A0.36133613
93MAPK40.35689341
94PRKCQ0.34260095
95DDR20.34062503
96MAP2K30.33415738
97MAP3K90.32511201
98PDK30.32074935
99PDK40.32074935
100MTOR0.31881101
101MAPK80.31868770
102MAPK140.31420623
103BTK0.31108413
104DAPK20.29713320
105MOS0.29238790
106MAP4K20.29059905
107MAP3K70.28899422
108ICK0.28834782
109MINK10.28522499
110CDK70.28440047
111DAPK30.28366061
112PHKG10.27848446
113PHKG20.27848446
114RPS6KL10.27522546
115RPS6KC10.27522546
116MELK0.27197189
117RET0.26598824
118TAOK10.26066324
119MAPK100.24310673
120FYN0.24040829
121ADRBK10.23065633
122MUSK0.22847516
123RPS6KB10.21750530
124PTK20.21453430
125AKT10.21207969
126RIPK10.20499426
127NLK0.20252701
128CDK10.20134061
129PRKCZ0.20089344
130STK380.20016295
131WNK10.19182981
132CAMKK10.18553686
133EPHB10.18387045
134BRSK20.18189471
135RPS6KA60.17597743
136PAK10.17340532
137GRK10.17129956
138EGFR0.16156555
139WNK40.15684384
140PRKAA10.15085708
141PRKD10.15033075
142MAPKAPK50.14354051
143BMX0.13288976
144MAP3K40.13056931
145TGFBR10.12526707
146RPS6KA10.12467654
147INSR0.11770153

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.84898251
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.81061622
3Fatty acid biosynthesis_Homo sapiens_hsa000614.61443511
4Protein export_Homo sapiens_hsa030603.81507826
5Sulfur metabolism_Homo sapiens_hsa009203.77155552
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.24758749
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.73065224
8N-Glycan biosynthesis_Homo sapiens_hsa005102.72048402
9Vibrio cholerae infection_Homo sapiens_hsa051102.45569838
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36407243
11Renin-angiotensin system_Homo sapiens_hsa046141.98231655
12Prostate cancer_Homo sapiens_hsa052151.94212287
13Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.93112385
14Other glycan degradation_Homo sapiens_hsa005111.91664137
15Fatty acid metabolism_Homo sapiens_hsa012121.85331400
16Arachidonic acid metabolism_Homo sapiens_hsa005901.81136423
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65288178
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65174600
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.59820957
20Arginine biosynthesis_Homo sapiens_hsa002201.56390329
21Linoleic acid metabolism_Homo sapiens_hsa005911.52277064
22Collecting duct acid secretion_Homo sapiens_hsa049661.49008891
23Endometrial cancer_Homo sapiens_hsa052131.46024693
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.43813862
25Circadian rhythm_Homo sapiens_hsa047101.43119853
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40002761
27Phenylalanine metabolism_Homo sapiens_hsa003601.31691098
28Propanoate metabolism_Homo sapiens_hsa006401.31347216
29Bladder cancer_Homo sapiens_hsa052191.29708282
30Fructose and mannose metabolism_Homo sapiens_hsa000511.28797283
31Tight junction_Homo sapiens_hsa045301.28127913
32Histidine metabolism_Homo sapiens_hsa003401.27924650
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22826171
34Amoebiasis_Homo sapiens_hsa051461.19819688
35Thyroid hormone synthesis_Homo sapiens_hsa049181.18684696
36Mineral absorption_Homo sapiens_hsa049781.11668205
37Small cell lung cancer_Homo sapiens_hsa052221.10704648
38Butanoate metabolism_Homo sapiens_hsa006501.10053420
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09746212
40Focal adhesion_Homo sapiens_hsa045101.09231686
41Cocaine addiction_Homo sapiens_hsa050301.07799893
42Steroid biosynthesis_Homo sapiens_hsa001001.06859713
43PPAR signaling pathway_Homo sapiens_hsa033201.04466403
44cAMP signaling pathway_Homo sapiens_hsa040241.03448575
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02798839
46Olfactory transduction_Homo sapiens_hsa047401.00905549
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00727814
48Hepatitis C_Homo sapiens_hsa051600.99629140
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98433462
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97881382
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96056074
52ErbB signaling pathway_Homo sapiens_hsa040120.94276848
53ECM-receptor interaction_Homo sapiens_hsa045120.93838134
54mTOR signaling pathway_Homo sapiens_hsa041500.93025018
55Salivary secretion_Homo sapiens_hsa049700.92885388
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.92155670
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92122535
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91835584
59Synaptic vesicle cycle_Homo sapiens_hsa047210.91586576
60Adherens junction_Homo sapiens_hsa045200.90787358
61Sulfur relay system_Homo sapiens_hsa041220.90295475
62Non-small cell lung cancer_Homo sapiens_hsa052230.89292618
63Inositol phosphate metabolism_Homo sapiens_hsa005620.89247096
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88494018
65Vitamin digestion and absorption_Homo sapiens_hsa049770.85086396
66Lysosome_Homo sapiens_hsa041420.84263880
67Protein digestion and absorption_Homo sapiens_hsa049740.82500444
68Glioma_Homo sapiens_hsa052140.82335131
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82093611
70Fatty acid degradation_Homo sapiens_hsa000710.81679939
71Arginine and proline metabolism_Homo sapiens_hsa003300.80699687
72Pancreatic secretion_Homo sapiens_hsa049720.79879474
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79646141
74Amphetamine addiction_Homo sapiens_hsa050310.78023127
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71025919
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70935886
77Retinol metabolism_Homo sapiens_hsa008300.70723527
78ABC transporters_Homo sapiens_hsa020100.70644155
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69297831
80Insulin resistance_Homo sapiens_hsa049310.69044913
81Pancreatic cancer_Homo sapiens_hsa052120.68969001
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68521213
83Bile secretion_Homo sapiens_hsa049760.67174245
84Ovarian steroidogenesis_Homo sapiens_hsa049130.66566089
85Hedgehog signaling pathway_Homo sapiens_hsa043400.65515594
86Melanoma_Homo sapiens_hsa052180.64709143
87Oxytocin signaling pathway_Homo sapiens_hsa049210.64583603
88Peroxisome_Homo sapiens_hsa041460.64565467
89Tryptophan metabolism_Homo sapiens_hsa003800.63509318
90Tyrosine metabolism_Homo sapiens_hsa003500.63073614
91Glutathione metabolism_Homo sapiens_hsa004800.61414010
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61329879
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.60550785
94Thyroid cancer_Homo sapiens_hsa052160.60196427
95MicroRNAs in cancer_Homo sapiens_hsa052060.59937822
96VEGF signaling pathway_Homo sapiens_hsa043700.59295155
97Estrogen signaling pathway_Homo sapiens_hsa049150.59001630
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58588011
99Choline metabolism in cancer_Homo sapiens_hsa052310.58117633
100Insulin secretion_Homo sapiens_hsa049110.58014147
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.57025469
102Chronic myeloid leukemia_Homo sapiens_hsa052200.56218171
103Dilated cardiomyopathy_Homo sapiens_hsa054140.55545828
104Gap junction_Homo sapiens_hsa045400.54533731
105Serotonergic synapse_Homo sapiens_hsa047260.53561024
106Hippo signaling pathway_Homo sapiens_hsa043900.52399249
107Nitrogen metabolism_Homo sapiens_hsa009100.50989626
108AMPK signaling pathway_Homo sapiens_hsa041520.50526521
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.50155317
110Type II diabetes mellitus_Homo sapiens_hsa049300.49923784
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49327332
112Antigen processing and presentation_Homo sapiens_hsa046120.48957336
113Dorso-ventral axis formation_Homo sapiens_hsa043200.48894130
114Prion diseases_Homo sapiens_hsa050200.48256011
115TGF-beta signaling pathway_Homo sapiens_hsa043500.47723360
116Calcium signaling pathway_Homo sapiens_hsa040200.47532876
117Cholinergic synapse_Homo sapiens_hsa047250.46922018
118Pathways in cancer_Homo sapiens_hsa052000.46614252
119Proteoglycans in cancer_Homo sapiens_hsa052050.43667232
120Acute myeloid leukemia_Homo sapiens_hsa052210.42638092
121Renal cell carcinoma_Homo sapiens_hsa052110.42429113
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42154691
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42154189
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41532453
125Endocytosis_Homo sapiens_hsa041440.41293644
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41077045
127Pyruvate metabolism_Homo sapiens_hsa006200.38545313
128Sphingolipid metabolism_Homo sapiens_hsa006000.37759590
129MAPK signaling pathway_Homo sapiens_hsa040100.37544372
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37257621
131Notch signaling pathway_Homo sapiens_hsa043300.37207544
132FoxO signaling pathway_Homo sapiens_hsa040680.37155297
133Prolactin signaling pathway_Homo sapiens_hsa049170.37088982
134Fat digestion and absorption_Homo sapiens_hsa049750.36650608
135beta-Alanine metabolism_Homo sapiens_hsa004100.36517830
136Influenza A_Homo sapiens_hsa051640.36264107
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35514263
138Renin secretion_Homo sapiens_hsa049240.35148525
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34967249
140Gastric acid secretion_Homo sapiens_hsa049710.34503649
141Wnt signaling pathway_Homo sapiens_hsa043100.33461044
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33259603
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32962148
144Long-term potentiation_Homo sapiens_hsa047200.31537331
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.30930658
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28872246
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28858247
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28120916
149Insulin signaling pathway_Homo sapiens_hsa049100.25549866
150Starch and sucrose metabolism_Homo sapiens_hsa005000.24378828
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.24277969
152Phagosome_Homo sapiens_hsa041450.23231037
153Toxoplasmosis_Homo sapiens_hsa051450.23087114
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22913747
155Platelet activation_Homo sapiens_hsa046110.22371257
156Lysine degradation_Homo sapiens_hsa003100.22350502
157Phospholipase D signaling pathway_Homo sapiens_hsa040720.21115124

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