TGM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host (GO:0044406)8.76232301
2citrulline biosynthetic process (GO:0019240)8.73844441
3hair follicle morphogenesis (GO:0031069)8.59293435
4intermediate filament cytoskeleton organization (GO:0045104)7.06359515
5intermediate filament-based process (GO:0045103)6.84035346
6cell wall macromolecule catabolic process (GO:0016998)6.55801450
7cell wall macromolecule metabolic process (GO:0044036)6.55801450
8* peptide cross-linking (GO:0018149)6.45994736
9epidermis development (GO:0008544)6.32413871
10keratinocyte differentiation (GO:0030216)6.23665947
11molting cycle process (GO:0022404)5.89266731
12hair cycle process (GO:0022405)5.89266731
13establishment of skin barrier (GO:0061436)5.74825707
14citrulline metabolic process (GO:0000052)5.72326518
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.51523933
16peptidyl-arginine modification (GO:0018195)5.06420970
17regulation of water loss via skin (GO:0033561)5.06161123
18hemidesmosome assembly (GO:0031581)5.02808247
19epidermal cell differentiation (GO:0009913)4.90804147
20skin morphogenesis (GO:0043589)4.65114449
21keratinocyte development (GO:0003334)4.15198126
22hair cycle (GO:0042633)33.7196283
23molting cycle (GO:0042303)33.7196283
24hair follicle development (GO:0001942)3.92438820
25tooth mineralization (GO:0034505)3.92272999
26positive regulation of hair cycle (GO:0042635)3.91354957
27positive regulation of hair follicle development (GO:0051798)3.91354957
28negative regulation of keratinocyte proliferation (GO:0010839)3.90288464
29regulation of hair follicle development (GO:0051797)3.65332795
30positive regulation of meiotic cell cycle (GO:0051446)3.54524835
31regulation of keratinocyte differentiation (GO:0045616)3.51550485
32negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.50197709
33phosphatidylinositol acyl-chain remodeling (GO:0036149)3.46436594
34multicellular organismal water homeostasis (GO:0050891)3.38574036
35regulation of hair cycle (GO:0042634)3.31506103
36ectoderm development (GO:0007398)3.29728063
37bone trabecula formation (GO:0060346)3.20500483
38positive regulation of epidermis development (GO:0045684)3.06126015
39epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.02397360
40epithelium development (GO:0060429)2.99799413
41phosphatidylserine acyl-chain remodeling (GO:0036150)2.89543758
42gap junction assembly (GO:0016264)2.89366259
43negative regulation of protein localization to plasma membrane (GO:1903077)2.83425127
44water homeostasis (GO:0030104)2.82376113
45atrioventricular valve morphogenesis (GO:0003181)2.71060289
46ventricular cardiac muscle cell action potential (GO:0086005)2.69752589
47regulation of epidermal cell differentiation (GO:0045604)2.67637196
48regulation of epidermis development (GO:0045682)2.66652913
49phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.63979537
50cranial suture morphogenesis (GO:0060363)2.59643047
51cell surface receptor signaling pathway involved in heart development (GO:0061311)2.59009259
52positive regulation of epidermal cell differentiation (GO:0045606)2.42818086
53regulation of cardioblast differentiation (GO:0051890)2.41685063
54negative regulation of epidermis development (GO:0045683)2.39422570
55regulation of keratinocyte proliferation (GO:0010837)2.37964654
56wound healing, spreading of epidermal cells (GO:0035313)2.34161180
57regulation of mesenchymal cell apoptotic process (GO:2001053)2.34126444
58phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.30784844
59outflow tract septum morphogenesis (GO:0003148)2.29986434
60fatty acid elongation (GO:0030497)2.25312227
61negative regulation of cell fate specification (GO:0009996)2.23766611
62positive regulation of meiosis (GO:0045836)2.19513198
63regulation of transforming growth factor beta2 production (GO:0032909)2.17225451
64phosphatidylserine metabolic process (GO:0006658)2.17029582
65skin development (GO:0043588)2.13247880
66regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.11077269
67regulation of heart rate by cardiac conduction (GO:0086091)2.08974879
68lymph vessel development (GO:0001945)2.04059572
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.03344401
70phosphatidylcholine acyl-chain remodeling (GO:0036151)2.00947075
71intermediate filament organization (GO:0045109)12.5524701
72keratinization (GO:0031424)11.3436248
73desmosome organization (GO:0002934)10.9042661
74virion attachment to host cell (GO:0019062)10.4603370
75adhesion of symbiont to host cell (GO:0044650)10.4603370
76cell communication involved in cardiac conduction (GO:0086065)1.98747873
77epithelial cell-cell adhesion (GO:0090136)1.95625780
78cytoskeletal anchoring at plasma membrane (GO:0007016)1.94299768
79negative regulation of epidermal cell differentiation (GO:0045605)1.93326224
80regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.93291250
81ephrin receptor signaling pathway (GO:0048013)1.92376827
82positive regulation of monocyte chemotaxis (GO:0090026)1.90845089
83aging (GO:0007568)1.90079645
84G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.86879671
85regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.85522061
86keratinocyte proliferation (GO:0043616)1.85281827
87non-canonical Wnt signaling pathway (GO:0035567)1.82642624
88myotube differentiation (GO:0014902)1.81460488
89craniofacial suture morphogenesis (GO:0097094)1.81320243
90odontogenesis of dentin-containing tooth (GO:0042475)1.81077813
91lateral sprouting from an epithelium (GO:0060601)1.77902938
92wound healing, spreading of cells (GO:0044319)1.76222353
93cell-substrate junction assembly (GO:0007044)1.76137390
94lung-associated mesenchyme development (GO:0060484)1.75905891
95eyelid development in camera-type eye (GO:0061029)1.73902322
96establishment of planar polarity (GO:0001736)1.73530887
97establishment of tissue polarity (GO:0007164)1.73530887
98regulation of ruffle assembly (GO:1900027)1.72886928
99cardiac epithelial to mesenchymal transition (GO:0060317)1.72495031
100coronary vasculature morphogenesis (GO:0060977)1.70115935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.86258893
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.99095980
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.55925956
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.31156064
5NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.14492668
6CTCF_20526341_ChIP-Seq_ESCs_Human2.10370313
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.01746146
8TP63_17297297_ChIP-ChIP_HaCaT_Human13.3598050
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90061517
10E2F1_20622854_ChIP-Seq_HELA_Human1.81677649
11SOX9_24532713_ChIP-Seq_HFSC_Mouse1.75530443
12NANOG_20526341_ChIP-Seq_ESCs_Human1.65514836
13FOXO3_23340844_ChIP-Seq_DLD1_Human1.65208937
14TAF2_19829295_ChIP-Seq_ESCs_Human1.63694288
15CSB_26484114_Chip-Seq_FIBROBLAST_Human1.62781019
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61837592
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61837592
18ERG_20517297_ChIP-Seq_VCAP_Human1.60142409
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59765611
20EGR1_19032775_ChIP-ChIP_M12_Human1.59180243
21P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.58380763
22MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.58362855
23TP63_22573176_ChIP-Seq_HFKS_Human1.47719894
24CTCF_27219007_Chip-Seq_Bcells_Human1.46137028
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.42807208
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39002736
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.37629277
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.37157938
29AHR_22903824_ChIP-Seq_MCF-7_Human1.36155295
30RACK7_27058665_Chip-Seq_MCF-7_Human1.34989181
31* P53_21459846_ChIP-Seq_SAOS-2_Human1.34550782
32ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30514615
33ATF3_27146783_Chip-Seq_COLON_Human1.29706401
34YY1_22570637_ChIP-Seq_MALME-3M_Human1.28671122
35TP63_23658742_ChIP-Seq_EP156T_Human1.25662468
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24094240
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23412184
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.23056443
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19289799
40UBF1/2_26484160_Chip-Seq_HMECs_Human1.17891538
41* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17170528
42KLF5_25053715_ChIP-Seq_YYC3_Human1.15000392
43GATA3_24758297_ChIP-Seq_MCF-7_Human1.14832690
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14038602
45BCOR_27268052_Chip-Seq_Bcells_Human1.13637853
46CEBPB_22108803_ChIP-Seq_LS180_Human1.13557011
47GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11115595
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10506179
49AR_21572438_ChIP-Seq_LNCaP_Human1.09213961
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08707974
51SMC4_20622854_ChIP-Seq_HELA_Human1.07493374
52TP53_18474530_ChIP-ChIP_U2OS_Human1.07217682
53* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05444287
54PHF8_20622854_ChIP-Seq_HELA_Human1.05370273
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04635633
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04133923
57* BCL6_27268052_Chip-Seq_Bcells_Human1.03786450
58JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03724341
59LXR_22292898_ChIP-Seq_THP-1_Human1.03558081
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03306504
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02989282
62E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02326297
63GATA6_21074721_ChIP-Seq_CACO-2_Human1.02182266
64P68_20966046_ChIP-Seq_HELA_Human1.00916900
65GATA4_25053715_ChIP-Seq_YYC3_Human1.00912797
66RXR_22108803_ChIP-Seq_LS180_Human1.00773625
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00251825
68JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99904319
69CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98434673
70ERG_21242973_ChIP-ChIP_JURKAT_Human0.96217697
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96091250
72IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93053642
73RUNX1_27514584_Chip-Seq_MCF-7_Human0.91934544
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91838246
75* RAC3_21632823_ChIP-Seq_H3396_Human0.90407382
76SOX2_21211035_ChIP-Seq_LN229_Human0.90188060
77RNF2_27304074_Chip-Seq_ESCs_Mouse0.89858048
78GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89312536
79FOXH1_21741376_ChIP-Seq_ESCs_Human0.89215478
80TRIM28_21343339_ChIP-Seq_HEK293_Human0.88917943
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.88194626
82ELF1_20517297_ChIP-Seq_JURKAT_Human0.87596885
83RING1B_27294783_Chip-Seq_ESCs_Mouse0.86844897
84TCF4_18268006_ChIP-ChIP_LS174T_Human0.85980996
85RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85447948
86ZNF263_19887448_ChIP-Seq_K562_Human0.85317603
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85114974
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.85114974
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84388631
90KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82120617
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81117230
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.80004800
93SPI1_20517297_ChIP-Seq_HL60_Human0.79833745
94EZH2_27304074_Chip-Seq_ESCs_Mouse0.79609189
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78026086
96SOX2_20726797_ChIP-Seq_SW620_Human0.77376366
97* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76094317
98GATA3_26560356_Chip-Seq_TH1_Human0.74840502
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.74559222
100BCAT_22108803_ChIP-Seq_LS180_Human0.73781168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology8.28907452
2MP0002098_abnormal_vibrissa_morphology6.93545814
3MP0000647_abnormal_sebaceous_gland6.21519552
4MP0002796_impaired_skin_barrier5.48045491
5MP0000383_abnormal_hair_follicle5.43206562
6MP0005275_abnormal_skin_tensile5.08346464
7MP0010678_abnormal_skin_adnexa4.67868768
8MP0010234_abnormal_vibrissa_follicle4.57154397
9MP0000377_abnormal_hair_follicle4.06033071
10MP0000427_abnormal_hair_cycle3.89612521
11MP0005501_abnormal_skin_physiology3.36002467
12MP0003705_abnormal_hypodermis_morpholog3.29788135
13MP0002254_reproductive_system_inflammat2.96436145
14MP0001216_abnormal_epidermal_layer2.64594053
15MP0004381_abnormal_hair_follicle2.34328643
16MP0004947_skin_inflammation2.25363935
17MP0000367_abnormal_coat/_hair2.25161220
18MP0010771_integument_phenotype2.22951183
19MP0001243_abnormal_dermal_layer2.16871234
20MP0003453_abnormal_keratinocyte_physiol2.12051043
21MP0002060_abnormal_skin_morphology1.99429399
22MP0002234_abnormal_pharynx_morphology1.73546657
23MP0005409_darkened_coat_color1.67884171
24MP0000467_abnormal_esophagus_morphology1.67253478
25MP0000762_abnormal_tongue_morphology1.45585287
26MP0009931_abnormal_skin_appearance1.42364353
27MP0009053_abnormal_anal_canal1.40269250
28MP0001661_extended_life_span1.38165694
29MP0003566_abnormal_cell_adhesion1.28253402
30MP0003941_abnormal_skin_development1.25181016
31MP0000566_synostosis1.19214983
32MP0002095_abnormal_skin_pigmentation1.11787673
33MP0004885_abnormal_endolymph1.03177164
34MP0001191_abnormal_skin_condition0.94059524
35MP0004185_abnormal_adipocyte_glucose0.88301270
36MP0004264_abnormal_extraembryonic_tissu0.86720359
37MP0001346_abnormal_lacrimal_gland0.84181106
38MP0005451_abnormal_body_composition0.77894261
39MP0001340_abnormal_eyelid_morphology0.71749301
40MP0001851_eye_inflammation0.71622089
41MP0010030_abnormal_orbit_morphology0.63720227
42MP0000627_abnormal_mammary_gland0.61615284
43MP0001849_ear_inflammation0.60983021
44MP0002877_abnormal_melanocyte_morpholog0.59448847
45MP0003755_abnormal_palate_morphology0.59425358
46MP0003315_abnormal_perineum_morphology0.58511909
47MP0002282_abnormal_trachea_morphology0.52314254
48MP0002970_abnormal_white_adipose0.47074241
49MP0008438_abnormal_cutaneous_collagen0.47040607
50MP0001784_abnormal_fluid_regulation0.45553234
51MP0005023_abnormal_wound_healing0.43036797
52MP0002111_abnormal_tail_morphology0.40639719
53MP0002177_abnormal_outer_ear0.38742920
54MP0002697_abnormal_eye_size0.34829155
55MP0000537_abnormal_urethra_morphology0.33801868
56MP0002249_abnormal_larynx_morphology0.33243586
57MP0000432_abnormal_head_morphology0.30929965
58MP0003385_abnormal_body_wall0.29879961
59MP0002009_preneoplasia0.29498341
60MP0003937_abnormal_limbs/digits/tail_de0.27686137
61MP0009379_abnormal_foot_pigmentation0.26913915
62MP0009384_cardiac_valve_regurgitation0.26728366
63MP0005075_abnormal_melanosome_morpholog0.26066982
64MP0005248_abnormal_Harderian_gland0.25815741
65MP0004272_abnormal_basement_membrane0.24869005
66MP0003935_abnormal_craniofacial_develop0.24834756
67MP0001730_embryonic_growth_arrest0.22770162
68MP0000462_abnormal_digestive_system0.22582012
69MP0003950_abnormal_plasma_membrane0.21501531
70MP0002006_tumorigenesis0.20710144
71MP0000516_abnormal_urinary_system0.20699096
72MP0005367_renal/urinary_system_phenotyp0.20699096
73MP0010352_gastrointestinal_tract_polyps0.19967607
74MP0003191_abnormal_cellular_cholesterol0.17996718
75MP0000538_abnormal_urinary_bladder0.17785826
76MP0005193_abnormal_anterior_eye0.17611946
77MP0000465_gastrointestinal_hemorrhage0.17520096
78MP0000678_abnormal_parathyroid_gland0.17409116
79MP0005076_abnormal_cell_differentiation0.14820731
80MP0005257_abnormal_intraocular_pressure0.14574070
81MP0002233_abnormal_nose_morphology0.14124131
82MP0004742_abnormal_vestibular_system0.11227369
83MP0005508_abnormal_skeleton_morphology0.11187015
84MP0000428_abnormal_craniofacial_morphol0.10416757
85MP0003329_amyloid_beta_deposits0.10272639
86MP0005666_abnormal_adipose_tissue0.10147591
87MP0001286_abnormal_eye_development0.09979336
88MP0002166_altered_tumor_susceptibility0.09493624
89MP0003763_abnormal_thymus_physiology0.08705208
90MP0004197_abnormal_fetal_growth/weight/0.08306925
91MP0005187_abnormal_penis_morphology0.08024252
92MP0001188_hyperpigmentation0.07218921
93MP0000733_abnormal_muscle_development0.06146603
94MP0002084_abnormal_developmental_patter0.06077011
95MP0003448_altered_tumor_morphology0.05736314
96MP0005375_adipose_tissue_phenotype0.05715538
97MP0003890_abnormal_embryonic-extraembry0.05361970
98MP0009703_decreased_birth_body0.05021743
99MP0002109_abnormal_limb_morphology0.04976346
100MP0000613_abnormal_salivary_gland0.04108428

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)9.73869587
2Nail dystrophy (HP:0008404)6.81297066
3Abnormality of nail color (HP:0100643)6.66914546
4Abnormal hair laboratory examination (HP:0003328)6.65804800
5Follicular hyperkeratosis (HP:0007502)5.93138042
6Fragile nails (HP:0001808)5.67271803
7Fine hair (HP:0002213)5.15156495
8Alopecia of scalp (HP:0002293)5.13381861
9Palmoplantar hyperkeratosis (HP:0000972)4.81599571
10Onycholysis (HP:0001806)4.59744579
11Palmar hyperkeratosis (HP:0010765)4.55607086
12Thick nail (HP:0001805)4.44402880
13Plantar hyperkeratosis (HP:0007556)4.40028203
14Sparse eyelashes (HP:0000653)4.21858447
15Right ventricular cardiomyopathy (HP:0011663)4.13309903
16Increased IgE level (HP:0003212)4.00447009
17Congenital, generalized hypertrichosis (HP:0004540)3.90663047
18Oral leukoplakia (HP:0002745)3.85246104
19Erythema (HP:0010783)3.68940070
20Parakeratosis (HP:0001036)3.40611484
21Milia (HP:0001056)3.34743652
22Abnormality of the frontal sinuses (HP:0002687)3.18488047
23Amelogenesis imperfecta (HP:0000705)3.17383122
24Curly hair (HP:0002212)2.83532433
25Aplasia cutis congenita (HP:0001057)2.75672170
26Erythroderma (HP:0001019)2.72057482
27Ridged nail (HP:0001807)2.71244931
28Natal tooth (HP:0000695)2.63988994
29Advanced eruption of teeth (HP:0006288)2.41860474
30Abnormal blistering of the skin (HP:0008066)2.41753313
31Dry hair (HP:0011359)2.40160517
32Abnormality of the parietal bone (HP:0002696)2.34180780
33Congenital ichthyosiform erythroderma (HP:0007431)2.33814339
34Absent eyelashes (HP:0000561)2.07833994
35Hypohidrosis (HP:0000966)2.05767760
36Amniotic constriction ring (HP:0009775)2.00392181
37Abnormality of placental membranes (HP:0011409)2.00392181
38Ventricular fibrillation (HP:0001663)2.00084778
39Hypotrichosis (HP:0001006)13.5637665
40Woolly hair (HP:0002224)11.7282756
41Abnormality of hair growth rate (HP:0011363)10.5920812
42Slow-growing hair (HP:0002217)10.5920812
43Pili torti (HP:0003777)10.5879520
44Palmoplantar keratoderma (HP:0000982)1.99473827
45Concave nail (HP:0001598)1.96334084
46Abnormality of permanent molar morphology (HP:0011071)1.96110354
47Abnormality of the dental root (HP:0006486)1.96110354
48Taurodontia (HP:0000679)1.96110354
49Corneal erosion (HP:0200020)1.95430601
50Ventricular tachycardia (HP:0004756)1.92276395
51Pruritus (HP:0000989)1.91925976
52Abnormality of molar (HP:0011077)1.90729054
53Abnormality of molar morphology (HP:0011070)1.90729054
54Blepharitis (HP:0000498)1.87400861
55Abnormality of dental color (HP:0011073)1.79325855
56Lip pit (HP:0100267)1.78834854
57Abnormality of the dental pulp (HP:0006479)1.72548111
58Abnormality of the pupil (HP:0000615)1.71479036
59Widely patent fontanelles and sutures (HP:0004492)1.69491852
60Abnormality of the aortic arch (HP:0012303)1.68671696
61Abnormality of the neuromuscular junction (HP:0003398)1.66710436
62Fatigable weakness (HP:0003473)1.66710436
63Recurrent corneal erosions (HP:0000495)1.64285941
64Sparse scalp hair (HP:0002209)1.56667165
65Carious teeth (HP:0000670)1.53651188
66Anonychia (HP:0001798)1.51994705
67Keratoconjunctivitis sicca (HP:0001097)1.46805941
68Hyporeflexia of lower limbs (HP:0002600)1.44698397
69Widely spaced teeth (HP:0000687)1.41120107
70Acanthosis nigricans (HP:0000956)1.40292085
71Autoamputation (HP:0001218)1.40062662
72Abnormality of the fingernails (HP:0001231)1.39265046
73Craniofacial hyperostosis (HP:0004493)1.38107060
74Laryngomalacia (HP:0001601)1.36135425
75Selective tooth agenesis (HP:0001592)1.31987606
76Heterogeneous (HP:0001425)1.31311366
77Keratoconjunctivitis (HP:0001096)1.29766329
78Ectropion (HP:0000656)1.29275215
79Conjunctival hamartoma (HP:0100780)1.25501701
80Unilateral renal agenesis (HP:0000122)1.23012026
81Sudden death (HP:0001699)1.22480163
82Neonatal death (HP:0003811)1.20141168
83Hypoplastic labia majora (HP:0000059)1.19196201
84Gangrene (HP:0100758)1.16867795
85Furrowed tongue (HP:0000221)1.15105398
86Abnormality of the gastric mucosa (HP:0004295)1.13111138
87Corneal dystrophy (HP:0001131)1.13104783
88Absent hair (HP:0002298)1.11522384
89Achilles tendon contracture (HP:0001771)1.10741900
90Atrophic scars (HP:0001075)1.10428994
91Hyperhidrosis (HP:0000975)1.10214384
92Rectal prolapse (HP:0002035)1.09753157
93Squamous cell carcinoma (HP:0002860)1.06010046
94Abnormality of the labia majora (HP:0012881)1.05676652
95Hypoplastic toenails (HP:0001800)1.05585413
96Lack of skin elasticity (HP:0100679)1.03935639
97Wide cranial sutures (HP:0010537)1.03303170
98Neonatal onset (HP:0003623)1.02830148
99Variable expressivity (HP:0003828)1.01611997
100Abnormality of the Achilles tendon (HP:0005109)1.01425577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.55912581
2LATS13.86950312
3FER3.82152309
4EPHA23.81571024
5MAPKAPK33.80674606
6TAOK13.55305453
7EPHB23.09644341
8LATS22.95585568
9MAP3K32.53124187
10ERN12.43267938
11MAP3K22.37518555
12EEF2K2.32085520
13MAP3K92.23423998
14FGFR22.15852350
15BCR1.84946279
16RPS6KB21.82135235
17TRIB31.78610880
18ERBB41.72217319
19KSR21.69107990
20MAP3K111.39197728
21FGFR31.37351644
22FGFR11.35364577
23CDK61.30889517
24PAK61.30674538
25MAP2K61.28125080
26NME11.27375180
27PIK3CG1.26817108
28STK38L1.26459074
29RPS6KA41.23804998
30NTRK21.17558706
31STK31.09778181
32NEK11.05106575
33EPHB11.01984351
34TTN1.01774900
35MAP3K11.00376590
36MAP2K40.99079511
37MAPKAPK20.91868482
38RIPK10.91423103
39FGFR40.84077718
40PDGFRA0.83327996
41STK380.81838731
42MST1R0.80563165
43MAP2K10.79445699
44MAP3K70.76530948
45PRKCI0.76076179
46BRAF0.73220904
47BMX0.72804755
48PAK30.72602216
49TRPM70.71831564
50DYRK1B0.68430706
51MAP3K50.65889713
52CSNK1G10.63784811
53PTK20.62187827
54CSNK1E0.60703580
55TYRO30.60469696
56AKT30.59094544
57PAK20.57020317
58PTK60.56930475
59ERBB20.56796513
60RPS6KA10.54499617
61TTK0.53130284
62KSR10.52788543
63CDK90.52217072
64PBK0.49100725
65MAP3K80.47746523
66STK240.46985096
67PIM20.46948736
68MTOR0.46268692
69PRKD10.43924387
70ALK0.42919899
71MET0.42500581
72CSNK1A1L0.41773483
73MAPK120.40402536
74STK110.39649082
75ERBB30.38453719
76RET0.37799607
77GSK3A0.37341734
78DYRK20.37249567
79AURKB0.36456570
80CSNK1G30.36139882
81MARK20.35043751
82MAP2K30.33699657
83TGFBR10.32827497
84MAPK80.31187895
85FRK0.30635387
86MAPKAPK50.29887374
87LRRK20.29140982
88DMPK0.28668285
89CSNK1G20.28005175
90PRKACA0.26237489
91OBSCN0.25172619
92NEK20.24393637
93PKN20.24282178
94DDR20.24005721
95MAPK90.23474616
96CSNK1D0.23091807
97SGK30.22616413
98NTRK10.21531247
99CLK10.20413795
100JAK10.19264043

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005914.66479935
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.63463994
3Basal cell carcinoma_Homo sapiens_hsa052172.84725878
4Ether lipid metabolism_Homo sapiens_hsa005652.62701388
5Fat digestion and absorption_Homo sapiens_hsa049752.49024685
6Hedgehog signaling pathway_Homo sapiens_hsa043402.07342249
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.06047551
8Fatty acid elongation_Homo sapiens_hsa000622.02881546
9Dorso-ventral axis formation_Homo sapiens_hsa043201.91629501
10Melanogenesis_Homo sapiens_hsa049161.86791001
11Hippo signaling pathway_Homo sapiens_hsa043901.83749514
12Thyroid cancer_Homo sapiens_hsa052161.75890582
13VEGF signaling pathway_Homo sapiens_hsa043701.71634175
14Axon guidance_Homo sapiens_hsa043601.68021020
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64359347
16Arachidonic acid metabolism_Homo sapiens_hsa005901.63513144
17Glioma_Homo sapiens_hsa052141.55690661
18GnRH signaling pathway_Homo sapiens_hsa049121.54735361
19Phenylalanine metabolism_Homo sapiens_hsa003601.53739757
20Bladder cancer_Homo sapiens_hsa052191.50123512
21Adherens junction_Homo sapiens_hsa045201.42783642
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42732474
23Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38282724
24Proteoglycans in cancer_Homo sapiens_hsa052051.36190648
25Mineral absorption_Homo sapiens_hsa049781.36088689
26Endometrial cancer_Homo sapiens_hsa052131.32553633
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.30921073
28Tight junction_Homo sapiens_hsa045301.25543160
29p53 signaling pathway_Homo sapiens_hsa041151.25279345
30TGF-beta signaling pathway_Homo sapiens_hsa043501.22762873
31Long-term potentiation_Homo sapiens_hsa047201.19810049
32Wnt signaling pathway_Homo sapiens_hsa043101.18164580
33Long-term depression_Homo sapiens_hsa047301.13077087
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.12620797
35Non-small cell lung cancer_Homo sapiens_hsa052231.12464534
36MicroRNAs in cancer_Homo sapiens_hsa052061.10932971
37Acute myeloid leukemia_Homo sapiens_hsa052211.07769494
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06152808
39Estrogen signaling pathway_Homo sapiens_hsa049151.00902925
40Histidine metabolism_Homo sapiens_hsa003401.00728562
41Steroid biosynthesis_Homo sapiens_hsa001000.96112630
42Ras signaling pathway_Homo sapiens_hsa040140.95180618
43ECM-receptor interaction_Homo sapiens_hsa045120.93714323
44Caffeine metabolism_Homo sapiens_hsa002320.90888194
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90817065
46Tyrosine metabolism_Homo sapiens_hsa003500.90633978
47Gap junction_Homo sapiens_hsa045400.86920807
48Oocyte meiosis_Homo sapiens_hsa041140.84514299
49Pancreatic secretion_Homo sapiens_hsa049720.82582033
50ErbB signaling pathway_Homo sapiens_hsa040120.75283318
51Renal cell carcinoma_Homo sapiens_hsa052110.74567664
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.72029164
53Oxytocin signaling pathway_Homo sapiens_hsa049210.69606359
54Amoebiasis_Homo sapiens_hsa051460.69324553
55PPAR signaling pathway_Homo sapiens_hsa033200.68646895
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67879050
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67541412
58Rap1 signaling pathway_Homo sapiens_hsa040150.65417926
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.63840821
60Pancreatic cancer_Homo sapiens_hsa052120.62074998
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61977956
62Gastric acid secretion_Homo sapiens_hsa049710.59897959
63Prostate cancer_Homo sapiens_hsa052150.59671641
64Melanoma_Homo sapiens_hsa052180.59558725
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.59201583
66Renin secretion_Homo sapiens_hsa049240.59143152
67Prolactin signaling pathway_Homo sapiens_hsa049170.58680177
68Hepatitis C_Homo sapiens_hsa051600.58154058
69Focal adhesion_Homo sapiens_hsa045100.57138604
70Pathways in cancer_Homo sapiens_hsa052000.54148348
71Phototransduction_Homo sapiens_hsa047440.53951754
72Insulin resistance_Homo sapiens_hsa049310.53473686
73Chronic myeloid leukemia_Homo sapiens_hsa052200.53012679
74Pertussis_Homo sapiens_hsa051330.52135603
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51807371
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51648883
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49286499
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48320765
79Dopaminergic synapse_Homo sapiens_hsa047280.47713108
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47067879
81MAPK signaling pathway_Homo sapiens_hsa040100.46262583
82Notch signaling pathway_Homo sapiens_hsa043300.46072022
83Insulin signaling pathway_Homo sapiens_hsa049100.44954024
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44255089
85Platelet activation_Homo sapiens_hsa046110.44024067
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43615892
87Amphetamine addiction_Homo sapiens_hsa050310.43499244
88Protein digestion and absorption_Homo sapiens_hsa049740.42360334
89HTLV-I infection_Homo sapiens_hsa051660.42320492
90mTOR signaling pathway_Homo sapiens_hsa041500.42317461
91Ovarian steroidogenesis_Homo sapiens_hsa049130.42166783
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.41293874
93Choline metabolism in cancer_Homo sapiens_hsa052310.40562641
94FoxO signaling pathway_Homo sapiens_hsa040680.40098358
95Salivary secretion_Homo sapiens_hsa049700.39987098
96Dilated cardiomyopathy_Homo sapiens_hsa054140.38804514
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38276032
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36750884
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.35504396
100Endocytosis_Homo sapiens_hsa041440.35259238

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