TGM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.51160082
2sperm motility (GO:0030317)8.05275638
3regulation of female gonad development (GO:2000194)7.97024498
4acrosome reaction (GO:0007340)7.79995236
5reproduction (GO:0000003)7.73349967
6spermatid nucleus differentiation (GO:0007289)7.35814113
7regulation of acrosome reaction (GO:0060046)6.97285677
8binding of sperm to zona pellucida (GO:0007339)6.96953657
9chromosome condensation (GO:0030261)6.83046927
10sperm-egg recognition (GO:0035036)6.80857949
11cellular potassium ion homeostasis (GO:0030007)6.74796977
12fusion of sperm to egg plasma membrane (GO:0007342)6.71369620
13microtubule depolymerization (GO:0007019)6.51675109
14piRNA metabolic process (GO:0034587)6.48069612
15sperm capacitation (GO:0048240)6.44476354
16single strand break repair (GO:0000012)6.37048359
17DNA packaging (GO:0006323)6.32865831
18regulation of DNA methylation (GO:0044030)6.32581701
19sodium ion export (GO:0071436)6.10248389
20spermatid development (GO:0007286)5.93891164
21meiotic cell cycle (GO:0051321)5.72226035
22regulation of meiosis I (GO:0060631)5.67593901
23single fertilization (GO:0007338)5.65914236
24alanine transport (GO:0032328)5.63708850
25centriole replication (GO:0007099)5.62333952
26cellular sodium ion homeostasis (GO:0006883)5.61402551
27microtubule polymerization or depolymerization (GO:0031109)5.56341506
28oocyte development (GO:0048599)5.55665867
29L-serine transport (GO:0015825)5.55625626
30DNA methylation involved in gamete generation (GO:0043046)5.51955880
31cell-cell recognition (GO:0009988)5.49879763
32regulation of activation of Janus kinase activity (GO:0010533)5.38899336
33fertilization (GO:0009566)5.38389128
34protein polyglutamylation (GO:0018095)5.18505385
35spermatogenesis (GO:0007283)5.10555547
36male gamete generation (GO:0048232)5.08639135
37plasma membrane fusion (GO:0045026)5.03812289
38calcium ion-dependent exocytosis (GO:0017156)5.03595235
39regulation of histone H3-K9 methylation (GO:0051570)4.92038248
40gamete generation (GO:0007276)4.86260395
41serine transport (GO:0032329)4.78240227
42regulation of extracellular matrix disassembly (GO:0010715)4.73689031
43microtubule severing (GO:0051013)4.73593989
44negative regulation of sodium ion transport (GO:0010766)4.71360955
45negative regulation of histone methylation (GO:0031061)4.69311831
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.57613647
47centriole assembly (GO:0098534)4.57322923
48drinking behavior (GO:0042756)4.50657320
49rRNA methylation (GO:0031167)4.48451209
50potassium ion import (GO:0010107)4.45971366
51retinal cone cell development (GO:0046549)4.37056762
52female gamete generation (GO:0007292)4.36541933
53keratinization (GO:0031424)4.36050365
54germ cell development (GO:0007281)4.33479497
55negative regulation of tissue remodeling (GO:0034104)4.32848820
56phosphatidylethanolamine biosynthetic process (GO:0006646)4.30578488
57response to pheromone (GO:0019236)4.30333677
58cell communication by electrical coupling (GO:0010644)4.25132557
59low-density lipoprotein particle remodeling (GO:0034374)4.24832413
60protein kinase C signaling (GO:0070528)4.15818219
61potassium ion homeostasis (GO:0055075)4.13713547
62establishment of protein localization to Golgi (GO:0072600)4.11885838
63nucleus organization (GO:0006997)4.11749945
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09191392
65protein targeting to Golgi (GO:0000042)4.08389707
66cellular process involved in reproduction in multicellular organism (GO:0022412)4.06755179
67positive regulation of gastrulation (GO:2000543)4.06276195
68glycine transport (GO:0015816)4.04244268
69RNA destabilization (GO:0050779)4.03492301
70positive regulation of potassium ion transmembrane transport (GO:1901381)4.02470867
71sexual reproduction (GO:0019953)4.00956185
72phosphatidylethanolamine metabolic process (GO:0046337)3.95316289
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.95165534
74negative regulation of inclusion body assembly (GO:0090084)3.88811611
75multicellular organismal reproductive process (GO:0048609)3.88069080
76negative regulation of reproductive process (GO:2000242)3.86082190
77axonemal dynein complex assembly (GO:0070286)3.85471885
78retrograde transport, vesicle recycling within Golgi (GO:0000301)3.85076757
79receptor recycling (GO:0001881)3.83825893
80cilium or flagellum-dependent cell motility (GO:0001539)3.74833988
81regulation of steroid hormone secretion (GO:2000831)3.72474041
82G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.70647126
83cellular response to pH (GO:0071467)3.70111328
84regulation of cholesterol esterification (GO:0010872)3.68118816
85proline transport (GO:0015824)3.64639969
86positive regulation of histone H3-K4 methylation (GO:0051571)3.64637454
87negative regulation of cytosolic calcium ion concentration (GO:0051481)3.63100157
88positive regulation of humoral immune response (GO:0002922)3.62867061
89epithelial cilium movement (GO:0003351)3.61882476
90positive regulation of potassium ion transport (GO:0043268)3.61864982
91regulation of extracellular matrix organization (GO:1903053)3.58474953
92regulation of transcription involved in cell fate commitment (GO:0060850)3.57774932
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57280109
94cerebral cortex neuron differentiation (GO:0021895)3.55503423
95sodium ion homeostasis (GO:0055078)3.53829541
96rRNA modification (GO:0000154)3.50842910
97cell communication involved in cardiac conduction (GO:0086065)3.46290095
98negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.44575018
99response to acidic pH (GO:0010447)3.44314977
100hemidesmosome assembly (GO:0031581)3.42526464
101synaptonemal complex assembly (GO:0007130)3.36931941
102male meiosis I (GO:0007141)3.36591932
103regulation of axon regeneration (GO:0048679)3.36278134
104regulation of neuron projection regeneration (GO:0070570)3.36278134
105gene silencing (GO:0016458)3.33536166
106cilium movement (GO:0003341)3.32964421
107male meiosis (GO:0007140)3.32618264
108L-amino acid import (GO:0043092)3.31476215
109gene silencing by RNA (GO:0031047)3.28235567
110gamma-aminobutyric acid transport (GO:0015812)3.25204686
111locomotory exploration behavior (GO:0035641)3.21870188
112positive regulation of endothelial cell differentiation (GO:0045603)3.19638024
113negative regulation of protein tyrosine kinase activity (GO:0061099)3.18589954
114atrial cardiac muscle cell action potential (GO:0086014)3.17319653
115neurotransmitter uptake (GO:0001504)3.15727975
116regulation of cell maturation (GO:1903429)3.15131085
117regulation of Rab GTPase activity (GO:0032313)3.14446469
118positive regulation of Rab GTPase activity (GO:0032851)3.14446469
119cytoskeletal anchoring at plasma membrane (GO:0007016)3.13769178
120phosphate ion transmembrane transport (GO:0035435)3.13370225
121histone H3-K9 demethylation (GO:0033169)3.11785461
122desmosome organization (GO:0002934)3.11559852
123regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10678946
124relaxation of cardiac muscle (GO:0055119)3.10055491
125C4-dicarboxylate transport (GO:0015740)3.08539811
126membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.08474622
127seminiferous tubule development (GO:0072520)3.07460567
128positive regulation of skeletal muscle tissue development (GO:0048643)3.07120844
129DNA alkylation (GO:0006305)3.06789613
130DNA methylation (GO:0006306)3.06789613
131regulation of centriole replication (GO:0046599)3.06548920
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.05304908
133regulation of somitogenesis (GO:0014807)3.03336404
134amino acid import (GO:0043090)3.02112655
135sex differentiation (GO:0007548)3.01711679
136neuronal action potential propagation (GO:0019227)3.01380531
137regulation of norepinephrine secretion (GO:0014061)2.99405377
138motile cilium assembly (GO:0044458)2.99148423
139regulation of potassium ion transmembrane transport (GO:1901379)2.98088579
140glomerular epithelial cell development (GO:0072310)2.96808316
141regulation of long-term neuronal synaptic plasticity (GO:0048169)2.94672742
142negative regulation of adenylate cyclase activity (GO:0007194)2.93726613
143glomerular visceral epithelial cell development (GO:0072015)2.93028683
144positive regulation of histone methylation (GO:0031062)2.90574735
145chromosome organization involved in meiosis (GO:0070192)2.90498273
146negative regulation of Rho protein signal transduction (GO:0035024)2.90199240
147synaptonemal complex organization (GO:0070193)2.85770084
148meiosis I (GO:0007127)2.84478781
149positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.83322276
150regulation of meiosis (GO:0040020)2.83316674
151renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.82241159
152negative regulation of cyclase activity (GO:0031280)2.82174063
153gamma-aminobutyric acid signaling pathway (GO:0007214)2.82163629
154histone exchange (GO:0043486)2.80973085
155peristalsis (GO:0030432)2.77089922
156positive regulation of protein tyrosine kinase activity (GO:0061098)2.76845475
157regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75544991
158neutral amino acid transport (GO:0015804)2.74562556
159membrane repolarization (GO:0086009)2.74310665
160negative regulation of potassium ion transmembrane transport (GO:1901380)2.74298900
161regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.74221190
162membrane repolarization during action potential (GO:0086011)2.71198796
163activation of NF-kappaB-inducing kinase activity (GO:0007250)2.71151760
164nephron epithelium morphogenesis (GO:0072088)2.69928066
165nephron tubule morphogenesis (GO:0072078)2.69928066
166vocalization behavior (GO:0071625)2.68170127
167response to muscle activity (GO:0014850)2.64363461
168negative regulation of lyase activity (GO:0051350)2.63490065
169regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.61535318
170positive regulation of renal sodium excretion (GO:0035815)2.60525739
171regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.59624630
172positive regulation of extracellular matrix organization (GO:1903055)2.58232122
173lens fiber cell differentiation (GO:0070306)2.57158873
174positive regulation of ERBB signaling pathway (GO:1901186)2.56390132
175potassium ion export (GO:0071435)2.55223636
176positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.53721938
177regulation of superoxide anion generation (GO:0032928)2.52894950
178synaptic vesicle maturation (GO:0016188)2.52668016
179regulation of sodium ion transmembrane transporter activity (GO:2000649)2.50875915
180primary alcohol catabolic process (GO:0034310)2.50870531
181ventricular cardiac muscle cell action potential (GO:0086005)2.50570484
182regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.50096228
183negative regulation of ion transmembrane transporter activity (GO:0032413)2.47214501
184axon ensheathment in central nervous system (GO:0032291)2.46802755
185central nervous system myelination (GO:0022010)2.46802755
186regulation of cardiac muscle cell contraction (GO:0086004)2.46212212
187glutamate secretion (GO:0014047)2.45099945
188regulation of neuronal synaptic plasticity (GO:0048168)2.45002055
189artery smooth muscle contraction (GO:0014824)2.44965531
190cellular response to nitric oxide (GO:0071732)2.44727685
191negative regulation of cell killing (GO:0031342)2.44207918
192negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.44207918
193response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.44133680
194response to histamine (GO:0034776)2.43898030
195nephron tubule formation (GO:0072079)2.43073610
196regulation of protein tyrosine kinase activity (GO:0061097)2.41908998
197regulation of clathrin-mediated endocytosis (GO:2000369)2.40384249
198establishment of skin barrier (GO:0061436)2.39561512
199* peptide cross-linking (GO:0018149)2.38368996
200negative regulation of cAMP biosynthetic process (GO:0030818)2.35701415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.71679615
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.08940458
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71763386
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62390240
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42665249
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36544619
7DROSHA_22980978_ChIP-Seq_HELA_Human2.29932126
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23355285
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21941321
10EZH2_22144423_ChIP-Seq_EOC_Human2.20543305
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13243543
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13243543
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12858750
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.11431882
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10240608
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07832198
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.07832198
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05290174
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04501441
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.99744503
21GBX2_23144817_ChIP-Seq_PC3_Human1.98872985
22AR_21572438_ChIP-Seq_LNCaP_Human1.98459175
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96182277
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91813710
25ZNF274_21170338_ChIP-Seq_K562_Hela1.91491755
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91370705
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87363848
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84940439
29SMAD4_21741376_ChIP-Seq_EPCs_Human1.83724330
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83137305
31NANOG_20526341_ChIP-Seq_ESCs_Human1.80436733
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.76895891
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76405247
34CBP_20019798_ChIP-Seq_JUKART_Human1.76365085
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76365085
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.76361253
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73547136
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70951886
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.70867383
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68982760
41RXR_22108803_ChIP-Seq_LS180_Human1.68380314
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.66258333
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.64888709
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.64229787
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62288821
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60107478
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58564358
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57560388
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57560388
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57560388
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51259681
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48355083
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.47127519
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45593498
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44162431
56CTCF_20526341_ChIP-Seq_ESCs_Human1.43862545
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43827500
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43388159
59* RAC3_21632823_ChIP-Seq_H3396_Human1.42605250
60* TAF2_19829295_ChIP-Seq_ESCs_Human1.39937378
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37404697
62ERA_21632823_ChIP-Seq_H3396_Human1.36959864
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35058956
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34927567
65* SMRT_27268052_Chip-Seq_Bcells_Human1.34237546
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33582693
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32967060
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32346330
69P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.31920303
70ERG_20517297_ChIP-Seq_VCAP_Human1.31056798
71BCL6_27268052_Chip-Seq_Bcells_Human1.30705412
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.30494773
73ZNF263_19887448_ChIP-Seq_K562_Human1.29405291
74MYC_19829295_ChIP-Seq_ESCs_Human1.27629624
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27009438
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24786326
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24728215
78* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23546086
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.22913091
80REST_21632747_ChIP-Seq_MESCs_Mouse1.21111814
81* BCOR_27268052_Chip-Seq_Bcells_Human1.20710964
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.20052991
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19648852
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.19006594
85GF1_26923725_Chip-Seq_HPCs_Mouse1.18624190
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18364052
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18323231
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17636784
89P300_19829295_ChIP-Seq_ESCs_Human1.17403680
90KLF4_19829295_ChIP-Seq_ESCs_Human1.17322424
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.16144496
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16065390
93* P68_20966046_ChIP-Seq_HELA_Human1.16020762
94OCT4_20526341_ChIP-Seq_ESCs_Human1.15901023
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15800407
96CTCF_27219007_Chip-Seq_Bcells_Human1.15479918
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.15047504
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14743673
99SMAD4_21741376_ChIP-Seq_HESCs_Human1.14544128
100FOXH1_21741376_ChIP-Seq_EPCs_Human1.12731342
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.09409314
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09196619
103WDR5_24793694_ChIP-Seq_LNCAP_Human1.08697311
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.08531179
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.08039629
106SMC4_20622854_ChIP-Seq_HELA_Human1.07847436
107AHR_22903824_ChIP-Seq_MCF-7_Human1.07794334
108GATA3_21878914_ChIP-Seq_MCF-7_Human1.07672810
109KDM2B_26808549_Chip-Seq_K562_Human1.07205353
110RUNX2_22187159_ChIP-Seq_PCA_Human1.07067963
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07039120
112BCAT_22108803_ChIP-Seq_LS180_Human1.06746057
113CLOCK_20551151_ChIP-Seq_293T_Human1.06611144
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04700438
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.04008736
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03918118
117PHF8_20622854_ChIP-Seq_HELA_Human1.03540651
118NANOG_19829295_ChIP-Seq_ESCs_Human1.03313704
119SOX2_19829295_ChIP-Seq_ESCs_Human1.03313704
120FUS_26573619_Chip-Seq_HEK293_Human1.02998537
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02884624
122OCT4_19829295_ChIP-Seq_ESCs_Human1.01729139
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01381029
124ER_23166858_ChIP-Seq_MCF-7_Human0.99969310
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99695559
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99451376
127GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99139488
128TCF4_23295773_ChIP-Seq_U87_Human0.98940372
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98859297
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98818494
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.97516288
132* AR_25329375_ChIP-Seq_VCAP_Human0.96875653
133BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.96707794
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96625748
135KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96014953
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95933194
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.95896099
138RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95740516
139HTT_18923047_ChIP-ChIP_STHdh_Human0.95511418
140TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95478779
141STAT3_23295773_ChIP-Seq_U87_Human0.95003512
142OCT1_27270436_Chip-Seq_PROSTATE_Human0.93904761
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93571450
144P53_21459846_ChIP-Seq_SAOS-2_Human0.93433766
145REST_18959480_ChIP-ChIP_MESCs_Mouse0.92590861
146VDR_22108803_ChIP-Seq_LS180_Human0.92212383
147ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91973422
148CBX2_27304074_Chip-Seq_ESCs_Mouse0.91663203
149E2F1_20622854_ChIP-Seq_HELA_Human0.91031442
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90939747
151CBP_21632823_ChIP-Seq_H3396_Human0.90719058
152NFYB_21822215_ChIP-Seq_K562_Human0.89945903
153TP53_20018659_ChIP-ChIP_R1E_Mouse0.89901037
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89861438
155SMAD4_21799915_ChIP-Seq_A2780_Human0.89707587
156SOX2_22085726_ChIP-Seq_NPCs_Mouse0.89406742
157AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88914223
158P300_27268052_Chip-Seq_Bcells_Human0.88605952
159LXR_22158963_ChIP-Seq_LIVER_Mouse0.86216367
160LXR_22292898_ChIP-Seq_THP-1_Human0.86063580
161EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85907209
162AR_19668381_ChIP-Seq_PC3_Human0.84473807
163ARNT_22903824_ChIP-Seq_MCF-7_Human0.82869243
164WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81714527
165PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81660386
166KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81275835
167TP63_22573176_ChIP-Seq_HFKS_Human0.80870642
168SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79986016
169RUNX1_27514584_Chip-Seq_MCF-7_Human0.79273855
170CJUN_26792858_Chip-Seq_BT549_Human0.78104620
171NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77589056
172RACK7_27058665_Chip-Seq_MCF-7_Human0.76506772
173SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76231957
174YAP1_20516196_ChIP-Seq_MESCs_Mouse0.75925141
175KDM2B_26808549_Chip-Seq_DND41_Human0.74868551
176SOX2_21211035_ChIP-Seq_LN229_Gbm0.74713117
177STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.73608093
178CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73372536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.45482193
2MP0003718_maternal_effect7.05799842
3MP0005451_abnormal_body_composition4.19102422
4MP0005423_abnormal_somatic_nervous4.12036124
5MP0001929_abnormal_gametogenesis3.74183009
6MP0003698_abnormal_male_reproductive3.35322647
7MP0004859_abnormal_synaptic_plasticity3.13663379
8MP0004270_analgesia3.09967497
9MP0010234_abnormal_vibrissa_follicle3.05480384
10MP0002796_impaired_skin_barrier3.04700348
11MP0008877_abnormal_DNA_methylation3.03581075
12MP0008789_abnormal_olfactory_epithelium2.96621735
13MP0004885_abnormal_endolymph2.80976722
14MP0002138_abnormal_hepatobiliary_system2.78847073
15MP0005395_other_phenotype2.75957169
16MP0000678_abnormal_parathyroid_gland2.71594587
17MP0002161_abnormal_fertility/fecundity2.68122673
18MP0002254_reproductive_system_inflammat2.65775737
19MP0003705_abnormal_hypodermis_morpholog2.63586789
20MP0004185_abnormal_adipocyte_glucose2.55995554
21MP0006292_abnormal_olfactory_placode2.49220891
22MP0005623_abnormal_meninges_morphology2.47244241
23MP0005499_abnormal_olfactory_system2.44793900
24MP0005394_taste/olfaction_phenotype2.44793900
25MP0002139_abnormal_hepatobiliary_system2.44631986
26MP0004043_abnormal_pH_regulation2.34847741
27MP0005167_abnormal_blood-brain_barrier2.33904574
28MP0002210_abnormal_sex_determination2.32801276
29MP0005275_abnormal_skin_tensile2.27949715
30MP0003941_abnormal_skin_development2.25185055
31MP0003699_abnormal_female_reproductive2.16513185
32MP0000383_abnormal_hair_follicle2.14576252
33MP0003880_abnormal_central_pattern2.12454772
34MP0010678_abnormal_skin_adnexa2.11061274
35MP0000579_abnormal_nail_morphology2.10882394
36MP0002089_abnormal_postnatal_growth/wei2.08397475
37MP0002132_abnormal_respiratory_system2.08387207
38MP0003635_abnormal_synaptic_transmissio2.04689431
39MP0005501_abnormal_skin_physiology1.97281364
40MP0009046_muscle_twitch1.96163343
41MP0003646_muscle_fatigue1.93402338
42MP0003690_abnormal_glial_cell1.92947939
43MP0003329_amyloid_beta_deposits1.90922947
44MP0005377_hearing/vestibular/ear_phenot1.84229573
45MP0003878_abnormal_ear_physiology1.84229573
46MP0000653_abnormal_sex_gland1.82500245
47MP0010386_abnormal_urinary_bladder1.74710185
48MP0000647_abnormal_sebaceous_gland1.70376951
49MP0010771_integument_phenotype1.57347343
50MP0000566_synostosis1.55162558
51MP0008995_early_reproductive_senescence1.54706706
52MP0000049_abnormal_middle_ear1.54323145
53MP0001145_abnormal_male_reproductive1.49791528
54MP0005670_abnormal_white_adipose1.49697967
55MP0009745_abnormal_behavioral_response1.48527724
56MP0002060_abnormal_skin_morphology1.44595739
57MP0005083_abnormal_biliary_tract1.43313716
58MP0005332_abnormal_amino_acid1.43068871
59MP0001486_abnormal_startle_reflex1.43054859
60MP0002063_abnormal_learning/memory/cond1.40162988
61MP0005666_abnormal_adipose_tissue1.38577578
62MP0008057_abnormal_DNA_replication1.36408699
63MP0005360_urolithiasis1.36357920
64MP0002638_abnormal_pupillary_reflex1.35507958
65MP0003075_altered_response_to1.35182706
66MP0002272_abnormal_nervous_system1.33881312
67MP0002064_seizures1.29467051
68MP0002734_abnormal_mechanical_nocicepti1.28519734
69MP0005085_abnormal_gallbladder_physiolo1.28450369
70MP0001502_abnormal_circadian_rhythm1.27797717
71MP0004134_abnormal_chest_morphology1.27294628
72MP0004381_abnormal_hair_follicle1.26888455
73MP0002249_abnormal_larynx_morphology1.26415916
74MP0003633_abnormal_nervous_system1.25330823
75MP0005551_abnormal_eye_electrophysiolog1.22092117
76MP0001968_abnormal_touch/_nociception1.21196427
77MP0003077_abnormal_cell_cycle1.18466397
78MP0001119_abnormal_female_reproductive1.18235213
79MP0002928_abnormal_bile_duct1.16473935
80MP0000762_abnormal_tongue_morphology1.12901093
81MP0000427_abnormal_hair_cycle1.11460921
82MP0002572_abnormal_emotion/affect_behav1.10465537
83MP0003693_abnormal_embryo_hatching1.10046422
84MP0003566_abnormal_cell_adhesion1.07954491
85MP0003119_abnormal_digestive_system1.07226093
86MP0008569_lethality_at_weaning1.05964634
87MP0004145_abnormal_muscle_electrophysio1.05293645
88MP0001216_abnormal_epidermal_layer1.04761155
89MP0001963_abnormal_hearing_physiology1.03966454
90MP0003879_abnormal_hair_cell1.02486232
91MP0004947_skin_inflammation1.02357687
92MP0001849_ear_inflammation1.02018279
93MP0000462_abnormal_digestive_system1.01844856
94MP0001666_abnormal_nutrient_absorption1.01696475
95MP0008872_abnormal_physiological_respon1.01635424
96MP0005165_increased_susceptibility_to1.00091589
97MP0002067_abnormal_sensory_capabilities0.99291260
98MP0004133_heterotaxia0.97987526
99MP0004858_abnormal_nervous_system0.97792375
100MP0000467_abnormal_esophagus_morphology0.97287729
101MP0001440_abnormal_grooming_behavior0.95937862
102MP0003950_abnormal_plasma_membrane0.95293856
103MP0000733_abnormal_muscle_development0.94713618
104MP0002909_abnormal_adrenal_gland0.94072857
105MP0000428_abnormal_craniofacial_morphol0.93467805
106MP0001348_abnormal_lacrimal_gland0.93287898
107MP0000377_abnormal_hair_follicle0.92789217
108MP0001765_abnormal_ion_homeostasis0.92117813
109MP0002127_abnormal_cardiovascular_syste0.91746782
110MP0005084_abnormal_gallbladder_morpholo0.91716725
111MP0002234_abnormal_pharynx_morphology0.91608171
112MP0002653_abnormal_ependyma_morphology0.91085237
113MP0001958_emphysema0.90127952
114MP0008961_abnormal_basal_metabolism0.89958018
115MP0003763_abnormal_thymus_physiology0.88246575
116MP0009384_cardiac_valve_regurgitation0.87682279
117MP0000681_abnormal_thyroid_gland0.87107939
118MP0001984_abnormal_olfaction0.86989038
119MP0003122_maternal_imprinting0.86833325
120MP0002160_abnormal_reproductive_system0.85769735
121MP0005389_reproductive_system_phenotype0.85699350
122MP0002733_abnormal_thermal_nociception0.84790425
123MP0003183_abnormal_peptide_metabolism0.84356291
124MP0003631_nervous_system_phenotype0.84163944
125MP0005166_decreased_susceptibility_to0.83533778
126MP0000372_irregular_coat_pigmentation0.83418511
127MP0000631_abnormal_neuroendocrine_gland0.82973336
128MP0000026_abnormal_inner_ear0.81709104
129MP0003283_abnormal_digestive_organ0.81298261
130MP0001727_abnormal_embryo_implantation0.81137372
131MP0000751_myopathy0.79660504
132MP0003634_abnormal_glial_cell0.79155688
133MP0003045_fibrosis0.77664463
134MP0000604_amyloidosis0.75771471
135MP0010368_abnormal_lymphatic_system0.75586769
136MP0001501_abnormal_sleep_pattern0.75528715
137MP0005023_abnormal_wound_healing0.75521685
138MP0004742_abnormal_vestibular_system0.75419146
139MP0002735_abnormal_chemical_nociception0.74661640
140MP0001299_abnormal_eye_distance/0.74141944
141MP0005646_abnormal_pituitary_gland0.73183564
142MP0000747_muscle_weakness0.72477769
143MP0001340_abnormal_eyelid_morphology0.72372072
144MP0004142_abnormal_muscle_tone0.72203833
145MP0001970_abnormal_pain_threshold0.70494603
146MP0000534_abnormal_ureter_morphology0.69568438
147MP0001485_abnormal_pinna_reflex0.67835069
148MP0003252_abnormal_bile_duct0.67492680
149MP0003453_abnormal_keratinocyte_physiol0.66901471
150MP0002557_abnormal_social/conspecific_i0.66552704
151MP0010329_abnormal_lipoprotein_level0.66158877
152MP0005365_abnormal_bile_salt0.66156243
153MP0002098_abnormal_vibrissa_morphology0.65889412
154MP0010030_abnormal_orbit_morphology0.65567880
155MP0008058_abnormal_DNA_repair0.65057972
156MP0001664_abnormal_digestion0.64983399
157MP0002736_abnormal_nociception_after0.64826999
158MP0005645_abnormal_hypothalamus_physiol0.63072049
159MP0002229_neurodegeneration0.61762573
160MP0005379_endocrine/exocrine_gland_phen0.61545125
161MP0005310_abnormal_salivary_gland0.60201615
162MP0001879_abnormal_lymphatic_vessel0.57809888
163MP0010307_abnormal_tumor_latency0.57210053
164MP0001324_abnormal_eye_pigmentation0.56450975
165MP0002282_abnormal_trachea_morphology0.55866435
166MP0001764_abnormal_homeostasis0.53740141
167MP0003121_genomic_imprinting0.53670500
168MP0003936_abnormal_reproductive_system0.51605580
169MP0001986_abnormal_taste_sensitivity0.50205071
170MP0005647_abnormal_sex_gland0.50126062
171MP0001905_abnormal_dopamine_level0.49366123
172MP0003136_yellow_coat_color0.48002679
173MP0001756_abnormal_urination0.47578543
174MP0006276_abnormal_autonomic_nervous0.44234832
175MP0009840_abnormal_foam_cell0.42930109
176MP0009115_abnormal_fat_cell0.42631686

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)6.83315099
2Severe visual impairment (HP:0001141)6.14565654
3Onycholysis (HP:0001806)5.46892397
4Impulsivity (HP:0100710)5.44913614
5Abnormality of the nasal septum (HP:0000419)4.66542951
6Diplopia (HP:0000651)4.64038843
7Abnormality of binocular vision (HP:0011514)4.64038843
8Oligodactyly (hands) (HP:0001180)4.60306459
9Male infertility (HP:0003251)4.48720158
10Hemiplegia (HP:0002301)4.45933742
11Milia (HP:0001056)4.37788223
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.36201806
13Infertility (HP:0000789)4.22403132
14Submucous cleft hard palate (HP:0000176)4.02838128
15Abnormal ciliary motility (HP:0012262)3.95016622
16Osteomalacia (HP:0002749)3.94169295
17Fibular aplasia (HP:0002990)3.90486983
18Tubulointerstitial nephritis (HP:0001970)3.86930175
19Potter facies (HP:0002009)3.63881426
20Facial shape deformation (HP:0011334)3.63881426
21Abdominal situs inversus (HP:0003363)3.62854408
22Abnormality of abdominal situs (HP:0011620)3.62854408
23Lip pit (HP:0100267)3.60888553
24Spontaneous hematomas (HP:0007420)3.59538344
25Abnormality of the pubic bones (HP:0003172)3.57704756
26Azoospermia (HP:0000027)3.57456236
27Abnormal respiratory motile cilium physiology (HP:0012261)3.54062882
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.53355249
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.53305732
30Abnormality of the parathyroid morphology (HP:0011766)3.52431228
31Amyloidosis (HP:0011034)3.50909405
32Attenuation of retinal blood vessels (HP:0007843)3.49709939
33Hemiparesis (HP:0001269)3.49271343
34Confusion (HP:0001289)3.48684789
35Cone-rod dystrophy (HP:0000548)3.40804490
36Oligodactyly (HP:0012165)3.32949043
37Plantar hyperkeratosis (HP:0007556)3.31812721
38Anterior segment dysgenesis (HP:0007700)3.30491014
39Hypophosphatemic rickets (HP:0004912)3.29823658
40Joint hemorrhage (HP:0005261)3.28938452
41Tetraplegia (HP:0002445)3.28117095
42Abnormality of secondary sexual hair (HP:0009888)3.23541605
43Abnormality of the axillary hair (HP:0100134)3.23541605
44Exercise-induced myalgia (HP:0003738)3.11336833
45Abnormal delayed hypersensitivity skin test (HP:0002963)3.10491564
46Hypochromic anemia (HP:0001931)3.07274273
47Aplasia/Hypoplasia of the fovea (HP:0008060)3.04612582
48Hypoplasia of the fovea (HP:0007750)3.04612582
49Abnormal spermatogenesis (HP:0008669)3.04527701
50Chronic hepatic failure (HP:0100626)2.94870648
51Palmoplantar hyperkeratosis (HP:0000972)2.93832530
52Megalencephaly (HP:0001355)2.90717812
53Polygenic inheritance (HP:0010982)2.88722964
54Generalized tonic-clonic seizures (HP:0002069)2.88110780
55Neurofibrillary tangles (HP:0002185)2.87665666
56Bony spicule pigmentary retinopathy (HP:0007737)2.87415507
57Abnormal respiratory epithelium morphology (HP:0012253)2.84971998
58Abnormal respiratory motile cilium morphology (HP:0005938)2.84971998
59Split foot (HP:0001839)2.77911499
60Abnormal number of incisors (HP:0011064)2.76896743
61Hypoplastic ischia (HP:0003175)2.74456785
62Abnormality of nail color (HP:0100643)2.73149559
63Palmar hyperkeratosis (HP:0010765)2.72870488
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.70482685
65Hypoplastic pelvis (HP:0008839)2.64458988
66Fragile nails (HP:0001808)2.62228822
67Congenital sensorineural hearing impairment (HP:0008527)2.61335539
68Fragile skin (HP:0001030)2.61095646
69Cerebral inclusion bodies (HP:0100314)2.60013095
70Abnormal rod and cone electroretinograms (HP:0008323)2.56430907
71Aplasia/Hypoplasia of the earlobes (HP:0009906)2.56080140
72Ketoacidosis (HP:0001993)2.55050753
73Bell-shaped thorax (HP:0001591)2.54490950
74Widely patent fontanelles and sutures (HP:0004492)2.53981817
75Conjunctival hamartoma (HP:0100780)2.52908620
76Abnormality of macular pigmentation (HP:0008002)2.52843223
77Focal motor seizures (HP:0011153)2.52738668
78Multifactorial inheritance (HP:0001426)2.51671718
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51024521
80Abnormality of the fovea (HP:0000493)2.50849060
81Aplasia/Hypoplasia of the macula (HP:0008059)2.50202516
82Right ventricular cardiomyopathy (HP:0011663)2.45183659
83Supernumerary spleens (HP:0009799)2.44502963
84Truncal obesity (HP:0001956)2.42355530
85Wrist flexion contracture (HP:0001239)2.40975778
86Rhinitis (HP:0012384)2.34952187
87Aplasia/Hypoplasia affecting the retina (HP:0008061)2.33036636
88IgM deficiency (HP:0002850)2.31855542
89Abnormality of the ischium (HP:0003174)2.29960885
90Adrenal hypoplasia (HP:0000835)2.28383254
91Pili torti (HP:0003777)2.26311706
92Abnormality of the labia minora (HP:0012880)2.25412673
93Thick nail (HP:0001805)2.24659662
94Prolonged neonatal jaundice (HP:0006579)2.24212648
95Tubular atrophy (HP:0000092)2.23604797
96Premature rupture of membranes (HP:0001788)2.23317770
97Abnormal hair laboratory examination (HP:0003328)2.23222371
98Back pain (HP:0003418)2.21885614
99Abnormality of DNA repair (HP:0003254)2.21658354
100Hyperkalemia (HP:0002153)2.20212545
101Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.18885030
102Humeroradial synostosis (HP:0003041)2.18377681
103Synostosis involving the elbow (HP:0003938)2.18377681
104Gout (HP:0001997)2.17428072
105Optic nerve hypoplasia (HP:0000609)2.17101373
106Increased circulating renin level (HP:0000848)2.16772186
107Aplasia involving bones of the extremities (HP:0009825)2.16462966
108Aplasia involving bones of the upper limbs (HP:0009823)2.16462966
109Aplasia of the phalanges of the hand (HP:0009802)2.16462966
110Abnormal platelet volume (HP:0011876)2.16408584
111Barrel-shaped chest (HP:0001552)2.15638219
112Hypoplastic iliac wings (HP:0002866)2.13862637
113Aplasia/hypoplasia of the uterus (HP:0008684)2.13825071
114Nasal polyposis (HP:0100582)2.13327686
115Asymmetric septal hypertrophy (HP:0001670)2.12221794
116Enlarged epiphyses (HP:0010580)2.11934629
117Abnormality of the costochondral junction (HP:0000919)2.10817385
118Exercise-induced muscle cramps (HP:0003710)2.09867157
119Hypokinesia (HP:0002375)2.09588700
120Hypoalphalipoproteinemia (HP:0003233)2.08766816
121Absent forearm bone (HP:0003953)2.07971368
122Aplasia involving forearm bones (HP:0009822)2.07971368
123Metaphyseal irregularity (HP:0003025)2.07870270
124Dynein arm defect of respiratory motile cilia (HP:0012255)2.07444655
125Absent/shortened dynein arms (HP:0200106)2.07444655
126Gingival bleeding (HP:0000225)2.05183638
127Bronchomalacia (HP:0002780)2.04490366
128Myokymia (HP:0002411)2.04275244
129Hypotrichosis (HP:0001006)2.02303928
130Generalized aminoaciduria (HP:0002909)2.01150754
131Pseudobulbar signs (HP:0002200)2.00959386
132Congenital stationary night blindness (HP:0007642)2.00799696
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99789853
134Skin pits (HP:0100276)1.98643103
135Hamartoma (HP:0010566)1.97952077
136Median cleft lip (HP:0000161)1.97783893
137Ventricular fibrillation (HP:0001663)1.97574269
138Brittle hair (HP:0002299)1.97328077
139Petechiae (HP:0000967)1.95933126
140Supranuclear gaze palsy (HP:0000605)1.95116157
141Cholecystitis (HP:0001082)1.95017740
142Abnormal gallbladder physiology (HP:0012438)1.95017740
143Renal Fanconi syndrome (HP:0001994)1.94096099
144Intention tremor (HP:0002080)1.94049830
145Focal segmental glomerulosclerosis (HP:0000097)1.92962210
146Atrophic scars (HP:0001075)1.92414032
147Macular degeneration (HP:0000608)1.91425701
148Abnormality of dental color (HP:0011073)1.90887002
149Status epilepticus (HP:0002133)1.90084679
150Septo-optic dysplasia (HP:0100842)1.90067481
151Tubulointerstitial abnormality (HP:0001969)1.89978106
152Papillary thyroid carcinoma (HP:0002895)1.88120093
153Woolly hair (HP:0002224)1.87193779
154Purpura (HP:0000979)1.86635466
155Dysdiadochokinesis (HP:0002075)1.86020376
156Urticaria (HP:0001025)1.85459287
157Hamartoma of the eye (HP:0010568)1.84769299
158Visual hallucinations (HP:0002367)1.83348706
159Photophobia (HP:0000613)1.82780347
160Hyporeflexia of lower limbs (HP:0002600)1.82389850
161Neoplasm of the heart (HP:0100544)1.81871458
162Abnormality of the nasal mucosa (HP:0000433)1.81733789
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81427744
164Carpal bone hypoplasia (HP:0001498)1.79324075
165Metabolic alkalosis (HP:0200114)1.78454566
166Hypergonadotropic hypogonadism (HP:0000815)1.78122758
167Poor speech (HP:0002465)1.78046161
168Focal seizures (HP:0007359)1.76971931
169Supernumerary bones of the axial skeleton (HP:0009144)1.76783278
170Periauricular skin pits (HP:0100277)1.76172174
171Preauricular pit (HP:0004467)1.76172174
172Hypoplastic left heart (HP:0004383)1.75228838
173Corneal erosion (HP:0200020)1.74669864
174Short tibia (HP:0005736)1.74235410
175Abnormality of cochlea (HP:0000375)1.74052342
176Abnormal urine output (HP:0012590)1.73926486
177Premature ovarian failure (HP:0008209)1.73330412
178Abnormal finger flexion creases (HP:0006143)1.73202991
179Hypergammaglobulinemia (HP:0010702)1.72682625
180Hydroureter (HP:0000072)1.72669693
181Ectropion (HP:0000656)1.72553115
182Supernumerary ribs (HP:0005815)1.72445520
183Femoral bowing (HP:0002980)1.71187913
184Apathy (HP:0000741)1.70905819
185Congenital ichthyosiform erythroderma (HP:0007431)1.70476444
186Increased variability in muscle fiber diameter (HP:0003557)1.70164397
187Muscle stiffness (HP:0003552)1.69101709
188Epileptic encephalopathy (HP:0200134)1.65341219
189Increased connective tissue (HP:0009025)1.63168213
190Nail dystrophy (HP:0008404)1.62938248
191Scapular winging (HP:0003691)1.62867721
192Chorioretinal atrophy (HP:0000533)1.62826047
193Chest pain (HP:0100749)1.62582581
194Shallow orbits (HP:0000586)1.61293196
195Myotonia (HP:0002486)1.58175593
196Hyperparathyroidism (HP:0000843)1.58123554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNK26.46430865
2PLK45.93863732
3ARAF4.00712781
4TESK12.94460700
5INSRR2.81992574
6PTK62.77981422
7BRAF2.38522671
8STK242.31434672
9CLK12.30066208
10NTRK32.25015553
11NTRK22.23529980
12TNIK2.17357837
13MAP4K22.13694825
14NUAK12.11741358
15TTN2.09737533
16MST42.04597679
17TAOK32.03499697
18CDK121.99000635
19FGFR41.79157271
20BRD41.77134652
21EPHA41.73331022
22MAP3K91.66038048
23PKN11.64706564
24MINK11.63198420
25PHKG11.62916729
26PHKG21.62916729
27CDK71.61107556
28MAPK151.59979476
29KSR21.59525989
30STK381.58890508
31PLK21.57888807
32STK391.54383177
33IRAK21.49274646
34TAOK21.43501720
35FER1.43253120
36MOS1.42311593
37TYRO31.40650901
38AURKA1.39113821
39OXSR11.36957669
40MST1R1.36375001
41MAP3K71.36371161
42PDPK11.34109658
43FGFR21.32095738
44WNK41.30056418
45CAMKK11.27640363
46CDK91.25273804
47PKN21.19620915
48KSR11.18600450
49TLK11.18324138
50NEK61.16954393
51SGK21.16239341
52SGK31.15957178
53SGK4941.14164363
54SGK2231.14164363
55EPHB11.12920019
56MAPKAPK31.12903314
57IRAK31.09038487
58EPHA31.08533911
59NLK1.04627880
60PRKG11.04220021
61CAMK1G1.03984235
62PAK61.02299028
63MAP2K41.00827942
64TRIB31.00136933
65SIK10.99827696
66RET0.99645301
67STK30.95613811
68NTRK10.95104391
69TIE10.94141345
70MELK0.93307220
71MAP3K20.92079219
72PNCK0.91038493
73RIPK10.90497142
74DAPK20.90297502
75LATS10.89138188
76HCK0.88064116
77TTK0.87164319
78WNK10.85520554
79LATS20.85235104
80PIK3CG0.85190327
81ADRBK10.85183121
82MET0.85134313
83LMTK20.83721916
84ALK0.83685903
85PRKCH0.81086440
86STK38L0.80826385
87BRSK10.80787577
88PDGFRA0.80596455
89DYRK1A0.80065864
90FGFR30.79530335
91PRPF4B0.79145433
92CDC42BPA0.79018346
93NME10.78821422
94BTK0.78471336
95TAOK10.76939312
96CHEK10.76695575
97HIPK20.76094707
98MAP3K10.75757832
99PTK20.74395040
100PASK0.74253167
101MAP3K40.74248662
102PRKCZ0.72925756
103CDK50.71206993
104CDK20.69900509
105MAP3K80.69879295
106MTOR0.65952507
107PAK10.65918641
108PRKCI0.65435304
109CDK150.64593620
110CDC70.63525813
111CDK60.63512909
112ROCK20.63476719
113NEK20.61806098
114CAMKK20.60861581
115RPS6KA20.60829339
116SGK10.60498138
117PRKAA20.59242738
118MAP3K130.58862168
119CDK180.57959425
120PRKD30.57831919
121UHMK10.57811999
122ILK0.56643564
123FYN0.55494403
124CAMK2A0.54463791
125DDR20.54395719
126MAPK10.53290645
127BMX0.52884288
128RAF10.52033117
129STK110.51160703
130PLK10.49698121
131ADRBK20.49665718
132JAK20.49495319
133MAPK130.49303243
134SIK20.49174032
135CSNK1G10.49035306
136CDK11A0.48743085
137GRK60.48170130
138CDK10.47902123
139CAMK10.47183941
140LRRK20.47097845
141PDK10.46704136
142PRKD10.46661286
143CDK80.46537994
144CAMK2B0.46306790
145CSNK1D0.46065546
146WNK30.45513603
147PIK3CA0.45352641
148GSK3B0.45268016
149ERBB20.45233734
150CDK140.44860367
151RPS6KA10.44851139
152PRKACA0.44705878
153OBSCN0.44190541
154PAK30.44050403
155MAPK120.43811273
156RIPK40.43807037
157TRIM280.43790496
158PIM10.42913063
159CHUK0.42214258
160CAMK1D0.40818260
161CAMK40.40372651
162EEF2K0.37235657
163CHEK20.34478668
164RPS6KA60.33388016
165DYRK1B0.32765228
166PRKG20.32735242
167DMPK0.29555344
168BMPR1B0.28725063
169AURKB0.27408480
170MAPK100.27224989
171MUSK0.26276530
172RPS6KC10.25188499
173RPS6KL10.25188499
174CSNK1E0.24433268
175IKBKB0.23944802
176ATM0.22414361
177AKT10.21490487

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.46650833
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.12648425
3Nitrogen metabolism_Homo sapiens_hsa009103.91153775
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.29349361
5Ovarian steroidogenesis_Homo sapiens_hsa049133.27366568
6Caffeine metabolism_Homo sapiens_hsa002322.80587723
7Nicotine addiction_Homo sapiens_hsa050332.47045548
8Salivary secretion_Homo sapiens_hsa049702.39444908
9Oocyte meiosis_Homo sapiens_hsa041142.37487086
10Gastric acid secretion_Homo sapiens_hsa049712.28717325
11Phototransduction_Homo sapiens_hsa047442.22703622
12Cell cycle_Homo sapiens_hsa041102.14818920
13Bile secretion_Homo sapiens_hsa049762.08245994
14Pancreatic secretion_Homo sapiens_hsa049722.04087993
15Folate biosynthesis_Homo sapiens_hsa007901.91162705
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.89123968
17GABAergic synapse_Homo sapiens_hsa047271.87771512
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86144384
19Fatty acid biosynthesis_Homo sapiens_hsa000611.79107417
20Renin secretion_Homo sapiens_hsa049241.74838093
21RNA transport_Homo sapiens_hsa030131.66753611
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62653495
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58926800
24Morphine addiction_Homo sapiens_hsa050321.50119386
25Glutamatergic synapse_Homo sapiens_hsa047241.49301657
26Insulin secretion_Homo sapiens_hsa049111.48235987
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48095806
28Long-term potentiation_Homo sapiens_hsa047201.42662539
29RNA degradation_Homo sapiens_hsa030181.40172746
30Fatty acid degradation_Homo sapiens_hsa000711.40136382
31Circadian entrainment_Homo sapiens_hsa047131.38401477
32Vitamin B6 metabolism_Homo sapiens_hsa007501.36430961
33Base excision repair_Homo sapiens_hsa034101.31416997
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26383624
35ABC transporters_Homo sapiens_hsa020101.22462465
36Synaptic vesicle cycle_Homo sapiens_hsa047211.20217737
37Butanoate metabolism_Homo sapiens_hsa006501.18317189
38Fatty acid metabolism_Homo sapiens_hsa012121.16909109
39Sphingolipid metabolism_Homo sapiens_hsa006001.15133749
40Phenylalanine metabolism_Homo sapiens_hsa003601.14898759
41Mismatch repair_Homo sapiens_hsa034301.11663105
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11169756
43beta-Alanine metabolism_Homo sapiens_hsa004101.05607965
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04993845
45mTOR signaling pathway_Homo sapiens_hsa041501.02557717
46Glycerolipid metabolism_Homo sapiens_hsa005611.02193677
47Amphetamine addiction_Homo sapiens_hsa050311.02072894
48Dopaminergic synapse_Homo sapiens_hsa047281.01678548
49Protein digestion and absorption_Homo sapiens_hsa049741.01077858
50Olfactory transduction_Homo sapiens_hsa047400.99338663
51Dilated cardiomyopathy_Homo sapiens_hsa054140.98397982
52Fat digestion and absorption_Homo sapiens_hsa049750.97048389
53Fanconi anemia pathway_Homo sapiens_hsa034600.94502617
54Histidine metabolism_Homo sapiens_hsa003400.94393149
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93371783
56Nucleotide excision repair_Homo sapiens_hsa034200.92442019
57Cholinergic synapse_Homo sapiens_hsa047250.92256560
58Thyroid hormone synthesis_Homo sapiens_hsa049180.91200786
59Axon guidance_Homo sapiens_hsa043600.87841455
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.87459887
61Calcium signaling pathway_Homo sapiens_hsa040200.87344895
62Arginine biosynthesis_Homo sapiens_hsa002200.86792369
63Arginine and proline metabolism_Homo sapiens_hsa003300.85476087
64Oxytocin signaling pathway_Homo sapiens_hsa049210.85424486
65PPAR signaling pathway_Homo sapiens_hsa033200.85401439
66Dorso-ventral axis formation_Homo sapiens_hsa043200.85373127
67cAMP signaling pathway_Homo sapiens_hsa040240.85289650
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81926440
69Serotonergic synapse_Homo sapiens_hsa047260.81264133
70Melanogenesis_Homo sapiens_hsa049160.81095368
71Long-term depression_Homo sapiens_hsa047300.80733533
72p53 signaling pathway_Homo sapiens_hsa041150.79284941
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77384984
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77234895
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75677794
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73615948
77Type II diabetes mellitus_Homo sapiens_hsa049300.73301977
78Taste transduction_Homo sapiens_hsa047420.73249706
79Cardiac muscle contraction_Homo sapiens_hsa042600.73159685
80Allograft rejection_Homo sapiens_hsa053300.72491409
81Autoimmune thyroid disease_Homo sapiens_hsa053200.71809148
82GnRH signaling pathway_Homo sapiens_hsa049120.69511467
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.69421461
84Estrogen signaling pathway_Homo sapiens_hsa049150.68378965
85Hedgehog signaling pathway_Homo sapiens_hsa043400.67362891
86Renin-angiotensin system_Homo sapiens_hsa046140.66552363
87Circadian rhythm_Homo sapiens_hsa047100.65354067
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64934692
89ECM-receptor interaction_Homo sapiens_hsa045120.64327784
90Sulfur metabolism_Homo sapiens_hsa009200.63713272
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61666927
92Thyroid cancer_Homo sapiens_hsa052160.61291200
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61232703
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60392458
95Mineral absorption_Homo sapiens_hsa049780.59826704
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59746059
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.59664949
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59604000
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59577844
100Cocaine addiction_Homo sapiens_hsa050300.58695567
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58405647
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57484097
103MAPK signaling pathway_Homo sapiens_hsa040100.57408250
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57383577
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57267221
106Fatty acid elongation_Homo sapiens_hsa000620.56772881
107mRNA surveillance pathway_Homo sapiens_hsa030150.56738380
108Influenza A_Homo sapiens_hsa051640.55204577
109Linoleic acid metabolism_Homo sapiens_hsa005910.55140885
110B cell receptor signaling pathway_Homo sapiens_hsa046620.54844858
111Choline metabolism in cancer_Homo sapiens_hsa052310.53960590
112Adherens junction_Homo sapiens_hsa045200.53921139
113Basal cell carcinoma_Homo sapiens_hsa052170.53042719
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52761018
115VEGF signaling pathway_Homo sapiens_hsa043700.52048125
116Retinol metabolism_Homo sapiens_hsa008300.51743598
117Graft-versus-host disease_Homo sapiens_hsa053320.51528809
118Collecting duct acid secretion_Homo sapiens_hsa049660.51219017
119Tight junction_Homo sapiens_hsa045300.50954502
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50554827
121Gap junction_Homo sapiens_hsa045400.49454891
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49048538
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48956893
124Galactose metabolism_Homo sapiens_hsa000520.47938153
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.45526709
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.45254839
127TGF-beta signaling pathway_Homo sapiens_hsa043500.43717565
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.43652178
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.43235816
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43122871
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42711111
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42384635
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42132973
134Type I diabetes mellitus_Homo sapiens_hsa049400.42048136
135Tyrosine metabolism_Homo sapiens_hsa003500.41391534
136Tryptophan metabolism_Homo sapiens_hsa003800.41341315
137African trypanosomiasis_Homo sapiens_hsa051430.41176340
138Huntingtons disease_Homo sapiens_hsa050160.40849590
139Ether lipid metabolism_Homo sapiens_hsa005650.40155956
140Glioma_Homo sapiens_hsa052140.39864624
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39628872
142Inositol phosphate metabolism_Homo sapiens_hsa005620.39135669
143Glucagon signaling pathway_Homo sapiens_hsa049220.38586766
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38290380
145Proteoglycans in cancer_Homo sapiens_hsa052050.37877495
146Antigen processing and presentation_Homo sapiens_hsa046120.37276715
147Viral carcinogenesis_Homo sapiens_hsa052030.35057276
148Vitamin digestion and absorption_Homo sapiens_hsa049770.34599004
149Purine metabolism_Homo sapiens_hsa002300.33139356
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.32580062
151Endocytosis_Homo sapiens_hsa041440.28968838
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25923446
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25748169
154Herpes simplex infection_Homo sapiens_hsa051680.25072716
155Phagosome_Homo sapiens_hsa041450.23417396
156FoxO signaling pathway_Homo sapiens_hsa040680.22206851

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