TGOLN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.84458908
2positive regulation of gamma-delta T cell activation (GO:0046645)3.76864773
3antigen processing and presentation of endogenous antigen (GO:0019883)3.70839733
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68138651
5negative regulation of cell killing (GO:0031342)3.60784431
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.60784431
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53707170
8negative regulation of erythrocyte differentiation (GO:0045647)3.25921077
9positive regulation by symbiont of host defense response (GO:0052509)3.21475522
10modulation by symbiont of host defense response (GO:0052031)3.21475522
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21475522
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21475522
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.21475522
14modulation by symbiont of host immune response (GO:0052553)3.21475522
15cellular extravasation (GO:0045123)3.15957269
16detection of other organism (GO:0098543)3.13558377
17detection of molecule of bacterial origin (GO:0032490)3.06221151
18mannose metabolic process (GO:0006013)3.05626700
19response to peptidoglycan (GO:0032494)3.04338914
20regulation of extracellular matrix disassembly (GO:0010715)3.00551417
21protein localization to endosome (GO:0036010)2.96616851
22detection of bacterium (GO:0016045)2.92240315
23pinocytosis (GO:0006907)2.91864778
24macrophage activation involved in immune response (GO:0002281)2.90218415
25detection of external biotic stimulus (GO:0098581)2.89584830
26positive regulation of extracellular matrix organization (GO:1903055)2.88951941
27regulation of gamma-delta T cell activation (GO:0046643)2.85272838
28hypotonic response (GO:0006971)2.84125953
29response to laminar fluid shear stress (GO:0034616)2.75194444
30neutrophil activation involved in immune response (GO:0002283)2.72108014
31positive regulation of cellular amide metabolic process (GO:0034250)2.69023618
32regulation of gamma-delta T cell differentiation (GO:0045586)2.68398254
33regulation of leukocyte degranulation (GO:0043300)2.63145913
34antigen processing and presentation via MHC class Ib (GO:0002475)2.62613442
35embryonic process involved in female pregnancy (GO:0060136)2.62289349
36regulation of T-helper 2 cell differentiation (GO:0045628)2.59221989
37peptide catabolic process (GO:0043171)2.55368968
38response to muramyl dipeptide (GO:0032495)2.54659040
39negative regulation of fibrinolysis (GO:0051918)2.52379796
40regulation of myeloid leukocyte mediated immunity (GO:0002886)2.50324377
41detection of biotic stimulus (GO:0009595)2.47430436
42regulation of extracellular matrix organization (GO:1903053)2.47399451
43barbed-end actin filament capping (GO:0051016)2.45465593
44skin morphogenesis (GO:0043589)2.45106461
45germinal center formation (GO:0002467)2.44339516
46regulation of interferon-beta biosynthetic process (GO:0045357)2.43133557
47stress fiber assembly (GO:0043149)2.41467845
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.37755477
49response to host (GO:0075136)2.37755477
50response to host defenses (GO:0052200)2.37755477
51regulation of B cell receptor signaling pathway (GO:0050855)2.35735918
52regulation of mast cell degranulation (GO:0043304)2.35386009
53positive thymic T cell selection (GO:0045059)2.35265045
54COPI coating of Golgi vesicle (GO:0048205)2.33247783
55Golgi transport vesicle coating (GO:0048200)2.33247783
56negative regulation of fatty acid transport (GO:2000192)2.32106816
57regulation of cholesterol homeostasis (GO:2000188)2.31734518
58leukocyte aggregation (GO:0070486)2.31109472
59negative thymic T cell selection (GO:0045060)2.30873511
60glycosphingolipid catabolic process (GO:0046479)2.30570624
61positive regulation of receptor recycling (GO:0001921)2.29393995
62negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.28980578
63lipopolysaccharide-mediated signaling pathway (GO:0031663)2.27040245
64regulation of apoptotic cell clearance (GO:2000425)2.26362158
65cellular response to ethanol (GO:0071361)2.26045516
66negative regulation of interleukin-12 production (GO:0032695)2.25962379
67negative regulation of type 2 immune response (GO:0002829)2.25207400
68negative regulation of humoral immune response (GO:0002921)2.24528890
69negative regulation of lymphocyte mediated immunity (GO:0002707)2.22968391
70membrane raft organization (GO:0031579)2.22933134
71negative regulation of protein activation cascade (GO:2000258)2.20695293
72B cell receptor signaling pathway (GO:0050853)2.20266735
73cortical actin cytoskeleton organization (GO:0030866)2.19650881
74negative regulation of complement activation (GO:0045916)2.19115026
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.19061058
76cellular response to thyroid hormone stimulus (GO:0097067)2.18695895
77positive regulation of leukocyte degranulation (GO:0043302)2.18448831
78negative T cell selection (GO:0043383)2.17885099
79regulation of macrophage cytokine production (GO:0010935)2.17379751
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.17173475
81response to thyroid hormone (GO:0097066)2.16702836
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.16522385
83response to host immune response (GO:0052572)2.16522385
84response to interleukin-15 (GO:0070672)2.16294457
85regulation of complement activation (GO:0030449)2.16263851
86negative regulation of leukocyte mediated immunity (GO:0002704)2.16230164
87macrophage activation (GO:0042116)2.16229433
88positive regulation of phagocytosis (GO:0050766)2.14954783
89immunoglobulin mediated immune response (GO:0016064)2.12799757
90regulation of protein activation cascade (GO:2000257)2.12455973
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.12271288
92regulation of regulated secretory pathway (GO:1903305)2.11741885
93cell adhesion mediated by integrin (GO:0033627)2.11459097
94regulation of necroptotic process (GO:0060544)2.11410144
95regulation of fibrinolysis (GO:0051917)2.11294886
96regulation of tolerance induction (GO:0002643)2.11198739
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.10503987
98negative regulation of toll-like receptor signaling pathway (GO:0034122)2.09910015
99positive regulation of Cdc42 GTPase activity (GO:0043089)2.09740881
100regulation of mast cell activation involved in immune response (GO:0033006)2.09736217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.38095223
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.27248117
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23599595
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70103425
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64401702
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.59758372
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56365968
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.43332764
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.42514644
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32836308
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.26432396
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19421557
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.08601142
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.07183447
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06824904
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05649540
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.01085408
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98798690
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.98116188
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94390483
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94069675
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91649484
23TCF7_22412390_ChIP-Seq_EML_Mouse1.86661570
24SPI1_23127762_ChIP-Seq_K562_Human1.86188825
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.86062818
26* VDR_24763502_ChIP-Seq_THP-1_Human1.85408149
27RUNX_20019798_ChIP-Seq_JUKART_Human1.80664365
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.78962809
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78527038
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.77912095
31CLOCK_20551151_ChIP-Seq_293T_Human1.76999494
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73086185
33VDR_21846776_ChIP-Seq_THP-1_Human1.71395561
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70639478
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.70010363
36MYC_22102868_ChIP-Seq_BL_Human1.66996821
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.61783696
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.59922983
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59885263
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58754649
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.54529889
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.54148219
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53256427
44LXR_22292898_ChIP-Seq_THP-1_Human1.52337552
45VDR_24787735_ChIP-Seq_THP-1_Human1.51005691
46MAF_26560356_Chip-Seq_TH1_Human1.46550016
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41448387
48* KDM2B_26808549_Chip-Seq_DND41_Human1.41262961
49GATA1_19941826_ChIP-Seq_K562_Human1.39763281
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39698784
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39675543
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.39533367
53* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39056188
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38770904
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36490824
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35928007
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35458182
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35208513
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.34201992
60* FOXA2_19822575_ChIP-Seq_HepG2_Human1.33671424
61SCL_19346495_ChIP-Seq_HPC-7_Human1.33663883
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31680333
63* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31558889
64MYB_26560356_Chip-Seq_TH2_Human1.27501743
65RACK7_27058665_Chip-Seq_MCF-7_Human1.25468009
66* SPI1_23547873_ChIP-Seq_NB4_Human1.24306748
67* MYB_26560356_Chip-Seq_TH1_Human1.22240059
68UTX_26944678_Chip-Seq_JUKART_Human1.21091907
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18239825
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.17392423
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15436663
72PU_27001747_Chip-Seq_BMDM_Mouse1.14914704
73* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12196385
74GATA2_19941826_ChIP-Seq_K562_Human1.12159795
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11923377
76* KDM2B_26808549_Chip-Seq_K562_Human1.10590540
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.09709587
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09427081
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09297148
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08970905
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.08304490
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08080981
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08019216
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06911526
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.06508534
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.06508534
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05322176
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05322176
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04528671
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04280362
91* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03867456
92SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02838398
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02329812
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02211889
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.00908896
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00890947
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98538365
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98483811
99GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96745338
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96146186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.09373684
2MP0003436_decreased_susceptibility_to2.99870286
3MP0003172_abnormal_lysosome_physiology2.79728677
4MP0005058_abnormal_lysosome_morphology2.72679845
5MP0003191_abnormal_cellular_cholesterol2.59404639
6MP0003303_peritoneal_inflammation2.55410192
7MP0001835_abnormal_antigen_presentation2.42825734
8MP0003724_increased_susceptibility_to2.36538382
9MP0008438_abnormal_cutaneous_collagen2.31149879
10MP0005451_abnormal_body_composition2.21616247
11MP0009840_abnormal_foam_cell2.19831233
12MP0003566_abnormal_cell_adhesion2.09930719
13MP0003705_abnormal_hypodermis_morpholog2.09556069
14MP0002419_abnormal_innate_immunity2.02919831
15MP0005464_abnormal_platelet_physiology2.01508271
16MP0000685_abnormal_immune_system1.95537980
17MP0003091_abnormal_cell_migration1.89441316
18MP0006082_CNS_inflammation1.88886075
19MP0002139_abnormal_hepatobiliary_system1.86521880
20MP0001533_abnormal_skeleton_physiology1.79372078
21MP0005025_abnormal_response_to1.77526681
22MP0001958_emphysema1.75052167
23MP0001790_abnormal_immune_system1.73855952
24MP0005387_immune_system_phenotype1.73855952
25MP0005000_abnormal_immune_tolerance1.68826313
26MP0002998_abnormal_bone_remodeling1.66291060
27MP0004947_skin_inflammation1.63859059
28MP0008260_abnormal_autophagy1.63249963
29MP0005409_darkened_coat_color1.60237892
30MP0005360_urolithiasis1.58348874
31MP0009785_altered_susceptibility_to1.57803962
32MP0000858_altered_metastatic_potential1.57183356
33MP0001800_abnormal_humoral_immune1.55349799
34MP0010155_abnormal_intestine_physiology1.52946728
35MP0003828_pulmonary_edema1.52790655
36MP0002166_altered_tumor_susceptibility1.50372757
37MP0003183_abnormal_peptide_metabolism1.48640268
38MP0002877_abnormal_melanocyte_morpholog1.48273342
39MP0003279_aneurysm1.46629036
40MP0003763_abnormal_thymus_physiology1.46557188
41MP0002452_abnormal_antigen_presenting1.45986998
42MP0000604_amyloidosis1.45370670
43MP0005164_abnormal_response_to1.42900781
44MP0002723_abnormal_immune_serum1.42480796
45MP0005365_abnormal_bile_salt1.39789761
46MP0002420_abnormal_adaptive_immunity1.35769751
47MP0005023_abnormal_wound_healing1.35673519
48MP0001819_abnormal_immune_cell1.34337837
49MP0003075_altered_response_to1.34203970
50MP0005671_abnormal_response_to1.33389091
51MP0005076_abnormal_cell_differentiation1.32799323
52MP0002405_respiratory_system_inflammati1.28936481
53MP0010352_gastrointestinal_tract_polyps1.28289135
54MP0004883_abnormal_blood_vessel1.28082615
55MP0001845_abnormal_inflammatory_respons1.24218155
56MP0003866_abnormal_defecation1.22916656
57MP0003329_amyloid_beta_deposits1.22462423
58MP0003045_fibrosis1.21986163
59MP0001851_eye_inflammation1.20822217
60MP0003690_abnormal_glial_cell1.20580100
61MP0002148_abnormal_hypersensitivity_rea1.19858695
62MP0004510_myositis1.17985442
63MP0006054_spinal_hemorrhage1.14988316
64MP0002396_abnormal_hematopoietic_system1.13961046
65MP0008469_abnormal_protein_level1.10719254
66MP0003656_abnormal_erythrocyte_physiolo1.10183742
67MP0008004_abnormal_stomach_pH1.05552698
68MP0005166_decreased_susceptibility_to1.04454104
69MP0002933_joint_inflammation1.03295140
70MP0000716_abnormal_immune_system1.02600324
71MP0003448_altered_tumor_morphology1.01417608
72MP0002398_abnormal_bone_marrow1.00909596
73MP0001853_heart_inflammation1.00776193
74MP0003252_abnormal_bile_duct0.99605686
75MP0009333_abnormal_splenocyte_physiolog0.98229098
76MP0000249_abnormal_blood_vessel0.97973624
77MP0001915_intracranial_hemorrhage0.97484240
78MP0010234_abnormal_vibrissa_follicle0.97321144
79MP0004264_abnormal_extraembryonic_tissu0.95425911
80MP0010329_abnormal_lipoprotein_level0.95391074
81MP0001666_abnormal_nutrient_absorption0.94350111
82MP0002132_abnormal_respiratory_system0.93433939
83MP0000767_abnormal_smooth_muscle0.91837077
84MP0003868_abnormal_feces_composition0.91311869
85MP0004272_abnormal_basement_membrane0.90709679
86MP0003453_abnormal_keratinocyte_physiol0.90207133
87MP0009278_abnormal_bone_marrow0.88680385
88MP0010368_abnormal_lymphatic_system0.88331087
89MP0002006_tumorigenesis0.87598195
90MP0003795_abnormal_bone_structure0.86744899
91MP0000920_abnormal_myelination0.86717915
92MP0001545_abnormal_hematopoietic_system0.85827187
93MP0005397_hematopoietic_system_phenotyp0.85827187
94MP0005257_abnormal_intraocular_pressure0.85754976
95MP0005390_skeleton_phenotype0.85249481
96MP0002896_abnormal_bone_mineralization0.85120174
97MP0005085_abnormal_gallbladder_physiolo0.85090298
98MP0004808_abnormal_hematopoietic_stem0.85047715
99MP0002722_abnormal_immune_system0.84160915
100MP0002429_abnormal_blood_cell0.84053928

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.64071912
2Deep venous thrombosis (HP:0002625)3.26893455
3Abnormality of macrophages (HP:0004311)3.21370156
4Protrusio acetabuli (HP:0003179)3.16622700
5Systemic lupus erythematosus (HP:0002725)2.93492905
6Recurrent gram-negative bacterial infections (HP:0005420)2.89421612
7Recurrent abscess formation (HP:0002722)2.86558341
8Dysostosis multiplex (HP:0000943)2.84367801
9Gingival bleeding (HP:0000225)2.72283801
10Urinary glycosaminoglycan excretion (HP:0003541)2.71881520
11Mucopolysacchariduria (HP:0008155)2.71881520
12Recurrent bacterial skin infections (HP:0005406)2.68522754
13Abnormality of glycolipid metabolism (HP:0010969)2.66250129
14Abnormality of liposaccharide metabolism (HP:0010968)2.66250129
15Abnormality of glycosphingolipid metabolism (HP:0004343)2.66250129
16Peritonitis (HP:0002586)2.57442938
17Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55823961
18Abnormality of polysaccharide metabolism (HP:0011012)2.55823961
19Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55823961
20Vertebral compression fractures (HP:0002953)2.52241269
21Myositis (HP:0100614)2.51907831
22Arterial tortuosity (HP:0005116)2.51590168
23Amyloidosis (HP:0011034)2.46905802
24Vascular tortuosity (HP:0004948)2.45860875
25Abnormality of the common coagulation pathway (HP:0010990)2.44521927
26Spontaneous hematomas (HP:0007420)2.44514393
27Cerebral aneurysm (HP:0004944)2.42768601
28Aortic aneurysm (HP:0004942)2.41029485
29Abnormality of complement system (HP:0005339)2.39839342
30Spondylolisthesis (HP:0003302)2.38182934
31Orchitis (HP:0100796)2.38102453
32Premature rupture of membranes (HP:0001788)2.37897589
33Myocardial infarction (HP:0001658)2.35490117
34Gingivitis (HP:0000230)2.34102213
35Epistaxis (HP:0000421)2.33395643
36Prolonged bleeding time (HP:0003010)2.32119962
37Complement deficiency (HP:0004431)2.32112757
38Purpura (HP:0000979)2.28879897
39Mitral stenosis (HP:0001718)2.27545727
40Menorrhagia (HP:0000132)2.25426751
41Osteolytic defects of the hand bones (HP:0009699)2.23437194
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.23437194
43Hemorrhage of the eye (HP:0011885)2.22873078
44Gastrointestinal infarctions (HP:0005244)2.21939639
45Aortic dissection (HP:0002647)2.20866898
46Aneurysm (HP:0002617)2.18375693
47Glomerulonephritis (HP:0000099)2.18236834
48Increased cerebral lipofuscin (HP:0011813)2.12126707
49Flat acetabular roof (HP:0003180)2.11665807
50Dilatation of the ascending aorta (HP:0005111)2.10582386
51Joint hemorrhage (HP:0005261)2.05507893
52Vacuolated lymphocytes (HP:0001922)2.03151831
53Optic neuritis (HP:0100653)2.00881682
54Retrobulbar optic neuritis (HP:0100654)2.00881682
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00861694
56Loss of speech (HP:0002371)2.00296821
57Cellulitis (HP:0100658)2.00230917
58Recurrent skin infections (HP:0001581)1.98255840
59Cervical subluxation (HP:0003308)1.96838910
60Interstitial pulmonary disease (HP:0006530)1.96471571
61Xanthomatosis (HP:0000991)1.93739880
62Broad face (HP:0000283)1.93060415
63Recurrent fungal infections (HP:0002841)1.91273870
64Abnormal platelet volume (HP:0011876)1.90731640
65Polycythemia (HP:0001901)1.89184532
66Wormian bones (HP:0002645)1.86821952
67Abnormality of the peritoneum (HP:0002585)1.86233680
68Malnutrition (HP:0004395)1.82806657
69Thin bony cortex (HP:0002753)1.82454958
70Vasculitis (HP:0002633)1.82053963
71Subacute progressive viral hepatitis (HP:0006572)1.82019688
72Neurofibrillary tangles (HP:0002185)1.81709872
73Abnormality of monocarboxylic acid metabolism (HP:0010996)1.80022958
74Pulmonary infiltrates (HP:0002113)1.77284754
75Elevated erythrocyte sedimentation rate (HP:0003565)1.76431092
76Obstructive sleep apnea (HP:0002870)1.74975818
77Arterial thrombosis (HP:0004420)1.73054926
78Meningitis (HP:0001287)1.72994226
79Impaired platelet aggregation (HP:0003540)1.72407073
80Abnormal platelet function (HP:0011869)1.72407073
81Asymmetry of the thorax (HP:0001555)1.71787739
82Pustule (HP:0200039)1.71567449
83Increased mean platelet volume (HP:0011877)1.69920095
84Cardiovascular calcification (HP:0011915)1.69590403
85T lymphocytopenia (HP:0005403)1.68464804
86Cerebral inclusion bodies (HP:0100314)1.66640400
87Asymmetric septal hypertrophy (HP:0001670)1.66324907
88Recurrent cutaneous fungal infections (HP:0011370)1.66170255
89Chronic mucocutaneous candidiasis (HP:0002728)1.66170255
90Mediastinal lymphadenopathy (HP:0100721)1.65594368
91Periodontitis (HP:0000704)1.64301078
92Pulmonary embolism (HP:0002204)1.64227567
93Recurrent viral infections (HP:0004429)1.64219345
94Esophageal varix (HP:0002040)1.63654068
95Increased neuronal autofluorescent lipopigment (HP:0002074)1.62709470
96Nephritis (HP:0000123)1.62621254
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.61692054
98Osteomyelitis (HP:0002754)1.61384212
99Obstructive lung disease (HP:0006536)1.61207227
100Chronic obstructive pulmonary disease (HP:0006510)1.61207227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.22416803
2ERN13.21639547
3RIPK42.90821335
4TRIB32.53452666
5FGFR42.51015761
6RIPK12.46430143
7TYK22.37575493
8CDK122.13164669
9MAP3K141.98143140
10FGFR31.95358350
11MAP3K131.94808737
12EPHB11.89203585
13MAP4K11.85932497
14BLK1.82983888
15ZAP701.82532217
16MAP2K31.77503527
17JAK11.71423859
18TGFBR21.60440652
19MAP3K31.52386072
20CSK1.52242470
21PDGFRA1.50041028
22CDC42BPA1.45692781
23IRAK31.43019415
24ICK1.42801912
25SIK11.42067458
26MAP3K21.33459294
27TTN1.27753399
28JAK31.27578632
29KSR21.22727233
30NEK91.22107832
31MAP3K11.16996960
32IRAK41.14558195
33PDPK11.12241192
34TRPM71.12231082
35SMG11.11271583
36FES1.09768570
37TBK11.08032244
38CSF1R1.07593813
39YES11.02078804
40MST1R0.99322017
41GRK60.96318191
42PDK10.96278973
43HCK0.95138254
44MARK20.94149745
45PRKD20.93062656
46BTK0.92068462
47STK380.90842552
48PDGFRB0.88403089
49FGR0.87530988
50SYK0.86904506
51PKN20.86777692
52RET0.85570249
53JAK20.85453362
54SGK30.85296126
55SIK30.84077316
56PTK60.83784150
57TAOK10.83365455
58CDK60.83189393
59MAP3K70.81934065
60LMTK20.81146778
61DDR20.79638303
62IKBKE0.79324553
63HIPK20.76518315
64MAPK110.75763340
65STK100.74697963
66PAK40.74618209
67ITK0.74570867
68KIT0.72454663
69WNK10.71762175
70EEF2K0.71461598
71BMPR20.70982269
72MOS0.69708594
73LCK0.67853155
74PTK20.66180341
75MAPK70.65842129
76TAOK20.61198283
77EPHA20.61135578
78MYLK0.60836759
79MELK0.60394416
80EPHA30.60031205
81MAP3K100.59272810
82MAP3K60.58405194
83MAPK120.57478447
84PIK3CG0.56629227
85MTOR0.56184219
86LYN0.54823993
87CAMKK10.51309346
88IRAK10.49822668
89PRKG20.49512508
90TNK20.49026062
91CAMKK20.47760798
92TXK0.47660286
93SGK20.47361750
94SIK20.47123114
95FYN0.46376098
96NLK0.46069209
97RPS6KA20.45613691
98LATS10.43771412
99MAPKAPK20.43341013
100PRKAA20.42803147

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.73634896
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15892664
3Staphylococcus aureus infection_Homo sapiens_hsa051502.11582379
4Osteoclast differentiation_Homo sapiens_hsa043801.85044908
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.84398807
6Leishmaniasis_Homo sapiens_hsa051401.84182320
7Complement and coagulation cascades_Homo sapiens_hsa046101.82127858
8B cell receptor signaling pathway_Homo sapiens_hsa046621.59412355
9Acute myeloid leukemia_Homo sapiens_hsa052211.38133289
10Lysosome_Homo sapiens_hsa041421.37827875
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37290785
12Tuberculosis_Homo sapiens_hsa051521.33427803
13Non-small cell lung cancer_Homo sapiens_hsa052231.32844231
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.29817905
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28311838
16Chronic myeloid leukemia_Homo sapiens_hsa052201.27968469
17Toxoplasmosis_Homo sapiens_hsa051451.27210833
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26231394
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22287059
20Pancreatic cancer_Homo sapiens_hsa052121.21734528
21Pertussis_Homo sapiens_hsa051331.14517997
22Platelet activation_Homo sapiens_hsa046111.11358247
23Malaria_Homo sapiens_hsa051441.10886261
24TNF signaling pathway_Homo sapiens_hsa046681.09721173
25T cell receptor signaling pathway_Homo sapiens_hsa046601.09366912
26Amoebiasis_Homo sapiens_hsa051461.09211569
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08085159
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07353174
29Renal cell carcinoma_Homo sapiens_hsa052111.06610342
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06602441
31Influenza A_Homo sapiens_hsa051641.04648530
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.04271458
33Measles_Homo sapiens_hsa051621.00320652
34Allograft rejection_Homo sapiens_hsa053301.00219089
35Graft-versus-host disease_Homo sapiens_hsa053320.99980558
36Hematopoietic cell lineage_Homo sapiens_hsa046400.99576677
37Hepatitis C_Homo sapiens_hsa051600.99378908
38Chemokine signaling pathway_Homo sapiens_hsa040620.98690379
39Phagosome_Homo sapiens_hsa041450.98385169
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97550863
41Hepatitis B_Homo sapiens_hsa051610.96286383
42Focal adhesion_Homo sapiens_hsa045100.95907935
43Insulin resistance_Homo sapiens_hsa049310.93252007
44Autoimmune thyroid disease_Homo sapiens_hsa053200.92143577
45VEGF signaling pathway_Homo sapiens_hsa043700.91494802
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90762964
47Viral myocarditis_Homo sapiens_hsa054160.90616040
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.89407243
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.88969656
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88110436
51Endometrial cancer_Homo sapiens_hsa052130.88030019
52GnRH signaling pathway_Homo sapiens_hsa049120.84406754
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.84225947
54Prion diseases_Homo sapiens_hsa050200.83622513
55Antigen processing and presentation_Homo sapiens_hsa046120.81530555
56Type I diabetes mellitus_Homo sapiens_hsa049400.80621960
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.80565946
58Prolactin signaling pathway_Homo sapiens_hsa049170.80470234
59Proteoglycans in cancer_Homo sapiens_hsa052050.79399167
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79316670
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77177594
62mTOR signaling pathway_Homo sapiens_hsa041500.76567175
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74073800
64Shigellosis_Homo sapiens_hsa051310.74011298
65Inositol phosphate metabolism_Homo sapiens_hsa005620.73655268
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.73419892
67Renin-angiotensin system_Homo sapiens_hsa046140.70819969
68Choline metabolism in cancer_Homo sapiens_hsa052310.70681305
69Dorso-ventral axis formation_Homo sapiens_hsa043200.70234216
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69229249
71Endocytosis_Homo sapiens_hsa041440.68861513
72Prostate cancer_Homo sapiens_hsa052150.68830145
73Bile secretion_Homo sapiens_hsa049760.67704922
74Apoptosis_Homo sapiens_hsa042100.67676667
75African trypanosomiasis_Homo sapiens_hsa051430.66977109
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66694549
77Salmonella infection_Homo sapiens_hsa051320.66513689
78Glioma_Homo sapiens_hsa052140.65948009
79Estrogen signaling pathway_Homo sapiens_hsa049150.64640746
80Legionellosis_Homo sapiens_hsa051340.64631877
81PPAR signaling pathway_Homo sapiens_hsa033200.64391390
82Bladder cancer_Homo sapiens_hsa052190.63420459
83FoxO signaling pathway_Homo sapiens_hsa040680.63387353
84Thyroid cancer_Homo sapiens_hsa052160.62382895
85Galactose metabolism_Homo sapiens_hsa000520.62377914
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62313919
87Herpes simplex infection_Homo sapiens_hsa051680.61463025
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.61186423
89Adherens junction_Homo sapiens_hsa045200.60846202
90Small cell lung cancer_Homo sapiens_hsa052220.60239631
91HIF-1 signaling pathway_Homo sapiens_hsa040660.59256654
92Starch and sucrose metabolism_Homo sapiens_hsa005000.59175522
93ECM-receptor interaction_Homo sapiens_hsa045120.58733414
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58360590
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58007650
96Notch signaling pathway_Homo sapiens_hsa043300.57700943
97Insulin signaling pathway_Homo sapiens_hsa049100.57382072
98ErbB signaling pathway_Homo sapiens_hsa040120.55232934
99Sphingolipid metabolism_Homo sapiens_hsa006000.54955895
100Rheumatoid arthritis_Homo sapiens_hsa053230.54555079

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