TH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)9.92088808
2catecholamine transport (GO:0051937)9.05549379
3* catecholamine biosynthetic process (GO:0042423)7.48773434
4* catechol-containing compound biosynthetic process (GO:0009713)7.48773434
5neurotransmitter catabolic process (GO:0042135)7.04242470
6regulation of catecholamine metabolic process (GO:0042069)6.51554645
7regulation of dopamine metabolic process (GO:0042053)6.51554645
8* dopamine metabolic process (GO:0042417)6.06029548
9neuron cell-cell adhesion (GO:0007158)5.88964603
10* alkaloid metabolic process (GO:0009820)5.83512774
11monoamine transport (GO:0015844)5.53171724
12* neurotransmitter biosynthetic process (GO:0042136)5.40807811
13prepulse inhibition (GO:0060134)5.32281277
14pyrimidine nucleobase catabolic process (GO:0006208)5.30359604
15synaptic transmission, cholinergic (GO:0007271)5.25749804
16enteric nervous system development (GO:0048484)5.18710885
17glutamate secretion (GO:0014047)5.13512079
18synaptic vesicle exocytosis (GO:0016079)5.08161963
19negative regulation of microtubule polymerization (GO:0031115)5.04906738
20regulation of dopamine secretion (GO:0014059)5.03969384
21negative regulation of neurotransmitter transport (GO:0051589)4.70697786
22behavioral response to nicotine (GO:0035095)4.66614652
23response to cocaine (GO:0042220)4.66526601
24regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.65545588
25regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.65545588
26auditory behavior (GO:0031223)4.64571373
27neurofilament cytoskeleton organization (GO:0060052)4.53317731
28behavioral response to cocaine (GO:0048148)4.52649966
29* phenol-containing compound biosynthetic process (GO:0046189)4.50222045
30* response to insecticide (GO:0017085)4.49311400
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.47257037
32positive regulation of glomerulus development (GO:0090193)4.32738036
33positive regulation of cell size (GO:0045793)4.29581485
34protein localization to synapse (GO:0035418)4.26839347
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.24117589
36* catecholamine metabolic process (GO:0006584)4.22193242
37* catechol-containing compound metabolic process (GO:0009712)4.22193242
38establishment of mitochondrion localization (GO:0051654)4.18062294
39behavioral response to ethanol (GO:0048149)4.14503117
40nucleobase catabolic process (GO:0046113)4.07979635
41regulation of short-term neuronal synaptic plasticity (GO:0048172)4.01902894
42* neurotransmitter metabolic process (GO:0042133)4.01136993
43regulation of oxidative phosphorylation (GO:0002082)4.00354215
44establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.96436702
45mitochondrion transport along microtubule (GO:0047497)3.96436702
46synapse assembly (GO:0007416)3.93963756
47neuron recognition (GO:0008038)3.78328535
48neurotransmitter secretion (GO:0007269)3.75003755
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.73969693
50neurotransmitter transport (GO:0006836)3.70258628
51* regulation of neurotransmitter levels (GO:0001505)3.68174791
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67410599
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.66311292
54neuronal action potential (GO:0019228)3.62104164
55* toxin metabolic process (GO:0009404)3.60557685
56synaptic vesicle maturation (GO:0016188)3.60113304
57regulation of vesicle fusion (GO:0031338)3.52420592
58regulation of synaptic transmission, dopaminergic (GO:0032225)3.51760972
59response to auditory stimulus (GO:0010996)3.50462939
60axonal fasciculation (GO:0007413)3.47352691
61positive regulation of vesicle fusion (GO:0031340)3.46897043
62ATP hydrolysis coupled proton transport (GO:0015991)3.46280794
63energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.46280794
64response to pain (GO:0048265)3.45001726
65* synaptic transmission, dopaminergic (GO:0001963)3.44745870
66neuromuscular synaptic transmission (GO:0007274)3.41440905
67synaptic transmission, glutamatergic (GO:0035249)3.40670671
68positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.40579161
69neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.39315233
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37243308
71opioid receptor signaling pathway (GO:0038003)3.35335291
72innervation (GO:0060384)3.34866134
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.34571641
74mechanosensory behavior (GO:0007638)3.34559364
75primary amino compound metabolic process (GO:1901160)3.31995932
76* establishment of synaptic vesicle localization (GO:0097480)3.31136970
77* synaptic vesicle transport (GO:0048489)3.31136970
78* response to nicotine (GO:0035094)3.29680425
79serotonin metabolic process (GO:0042428)3.29409797
80neuron maturation (GO:0042551)3.25613899
81regulation of receptor recycling (GO:0001919)3.24923972
82regulation of synaptic vesicle exocytosis (GO:2000300)3.24847657
83positive regulation of neurotransmitter transport (GO:0051590)3.23396477
84membrane depolarization during action potential (GO:0086010)3.20681878
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.18195277
86negative regulation of membrane potential (GO:0045837)3.16635017
87dendritic spine morphogenesis (GO:0060997)3.16081194
88regulation of catecholamine secretion (GO:0050433)3.15784155
89regulation of neurotransmitter uptake (GO:0051580)3.15366874
90regulation of clathrin-mediated endocytosis (GO:2000369)3.13534932
91cerebellar Purkinje cell layer development (GO:0021680)3.12697675
92electron transport chain (GO:0022900)3.12619078
93positive regulation of synapse assembly (GO:0051965)3.11909098
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11416670
95negative regulation of catecholamine secretion (GO:0033604)3.11188768
96energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08296256
97ATP synthesis coupled proton transport (GO:0015986)3.08296256
98respiratory electron transport chain (GO:0022904)3.08106254
99dendrite morphogenesis (GO:0048813)3.07365011
100transferrin transport (GO:0033572)3.07311278
101striatum development (GO:0021756)3.07178054
102response to iron ion (GO:0010039)3.04235310
103regulation of protein kinase A signaling (GO:0010738)3.02035160
104dopaminergic neuron differentiation (GO:0071542)3.01855571
105regulation of cell maturation (GO:1903429)3.01637481
106regulation of synapse structural plasticity (GO:0051823)2.98354562
107glutamate receptor signaling pathway (GO:0007215)2.98318977
108positive regulation of response to oxidative stress (GO:1902884)2.96331672
109positive regulation of cellular response to oxidative stress (GO:1900409)2.96331672
110synaptic vesicle endocytosis (GO:0048488)2.95436731
111vocalization behavior (GO:0071625)2.94551093
112negative regulation of amine transport (GO:0051953)2.93576009
113regulation of collateral sprouting (GO:0048670)2.92025714
114* neuron-neuron synaptic transmission (GO:0007270)2.91978495
115membrane depolarization (GO:0051899)2.91486703
116* response to amphetamine (GO:0001975)2.90960546
117synapse organization (GO:0050808)2.89392133
118regulation of synaptic vesicle transport (GO:1902803)2.88813926
119proline transport (GO:0015824)2.87948342
120exploration behavior (GO:0035640)2.87359505
121ferric iron transport (GO:0015682)2.87084813
122trivalent inorganic cation transport (GO:0072512)2.87084813
123regulation of glomerulus development (GO:0090192)2.86843495
124cellular response to epinephrine stimulus (GO:0071872)2.86824996
125positive regulation of growth hormone secretion (GO:0060124)2.86797397
126regulation of neurotransmitter transport (GO:0051588)2.85141403
127gamma-aminobutyric acid transport (GO:0015812)2.84911683
128regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84059022
129inositol phosphate catabolic process (GO:0071545)2.83942613
130cell migration in hindbrain (GO:0021535)2.83850142
131axon extension (GO:0048675)2.82943790
132inositol phosphate dephosphorylation (GO:0046855)2.81706786
133phosphorylated carbohydrate dephosphorylation (GO:0046838)2.81706786
134response to ammonium ion (GO:0060359)2.80839496
135dendrite development (GO:0016358)2.80714442
136apical protein localization (GO:0045176)2.80252881
137positive regulation of potassium ion transmembrane transport (GO:1901381)2.79553708
138calcium-mediated signaling using intracellular calcium source (GO:0035584)2.78921531
139postsynaptic membrane organization (GO:0001941)2.78009467
140protein localization to cilium (GO:0061512)2.77381869
141neurotransmitter-gated ion channel clustering (GO:0072578)2.76587927
142adult walking behavior (GO:0007628)2.73607712
143negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73082765
144regulation of postsynaptic membrane potential (GO:0060078)2.71637873
145membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65916103
146regulation of cAMP-dependent protein kinase activity (GO:2000479)2.63116439
147sex differentiation (GO:0007548)2.62448796
148response to histamine (GO:0034776)2.61952789
149positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.61312827
150positive regulation of multicellular organism growth (GO:0040018)2.61239278
151short-term memory (GO:0007614)2.58558417
152regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56695185
153dopamine transport (GO:0015872)11.5882901
154* dopamine biosynthetic process (GO:0042416)10.9708229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38044505
2TAF15_26573619_Chip-Seq_HEK293_Human3.87663463
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.28943821
4GBX2_23144817_ChIP-Seq_PC3_Human3.27180841
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14413835
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13560493
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.00198495
8IGF1R_20145208_ChIP-Seq_DFB_Human2.87369903
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64761636
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.63556246
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63210828
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59717331
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53833225
14ZNF274_21170338_ChIP-Seq_K562_Hela2.52812684
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45041373
16REST_21632747_ChIP-Seq_MESCs_Mouse2.43354800
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42917962
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42270303
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42270303
20* NR3C1_23031785_ChIP-Seq_PC12_Mouse2.41504333
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40865662
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38389182
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26682269
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.25325447
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21667585
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.20050935
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16657488
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.09453649
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08117961
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98270737
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.96557394
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.94330104
33DROSHA_22980978_ChIP-Seq_HELA_Human1.90989308
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88966237
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85387026
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81919922
37VDR_22108803_ChIP-Seq_LS180_Human1.79836025
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79523025
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.76280895
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71092976
41SMAD4_21799915_ChIP-Seq_A2780_Human1.67398059
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.65037693
43P300_19829295_ChIP-Seq_ESCs_Human1.63102496
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60440503
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59859472
46* BCAT_22108803_ChIP-Seq_LS180_Human1.50420830
47CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.49137466
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46128271
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.45971255
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.43240747
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40747047
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38771078
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.28812766
54AR_25329375_ChIP-Seq_VCAP_Human1.28571403
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28072433
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27135782
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.25186214
58AR_21572438_ChIP-Seq_LNCaP_Human1.24830829
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23534910
60ZNF263_19887448_ChIP-Seq_K562_Human1.21676743
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21090636
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.21038373
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21028919
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20960935
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.19162493
66RUNX2_22187159_ChIP-Seq_PCA_Human1.11393440
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10026813
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09893401
69JUN_21703547_ChIP-Seq_K562_Human1.09320302
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09065501
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09037271
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08690122
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08690122
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07126071
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05812117
76DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99555872
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98794105
78CBX2_27304074_Chip-Seq_ESCs_Mouse0.98487528
79CBP_20019798_ChIP-Seq_JUKART_Human0.97120515
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97120515
81* STAT3_23295773_ChIP-Seq_U87_Human0.96455958
82FUS_26573619_Chip-Seq_HEK293_Human0.96315887
83EWS_26573619_Chip-Seq_HEK293_Human0.95979209
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94379780
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93835492
86FLI1_21867929_ChIP-Seq_TH2_Mouse0.93228293
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92940958
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92598215
89AR_19668381_ChIP-Seq_PC3_Human0.92425615
90RING1B_27294783_Chip-Seq_ESCs_Mouse0.92420168
91* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92208528
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92039720
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91577006
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91314842
95RNF2_27304074_Chip-Seq_NSC_Mouse0.91211714
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.91060226
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91058307
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90505706
99TP53_18474530_ChIP-ChIP_U2OS_Human0.89891349
100RING1B_27294783_Chip-Seq_NPCs_Mouse0.89771993
101TAL1_26923725_Chip-Seq_HPCs_Mouse0.89649098
102* CTCF_27219007_Chip-Seq_Bcells_Human0.89161245
103* KDM2B_26808549_Chip-Seq_REH_Human0.88277324
104TCF4_23295773_ChIP-Seq_U87_Human0.87772391
105SOX9_26525672_Chip-Seq_HEART_Mouse0.86963137
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86922061
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86527674
108ER_23166858_ChIP-Seq_MCF-7_Human0.86489492
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86405995
110EP300_21415370_ChIP-Seq_HL-1_Mouse0.85963497
111NANOG_19829295_ChIP-Seq_ESCs_Human0.84608489
112SOX2_19829295_ChIP-Seq_ESCs_Human0.84608489
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.82653091
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.82289270
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81117170
116ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80246924
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79949570
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79418624
119REST_19997604_ChIP-ChIP_NEURONS_Mouse0.79015170
120TP53_16413492_ChIP-PET_HCT116_Human0.78604012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001905_abnormal_dopamine_level5.09445368
2MP0002822_catalepsy4.91555050
3MP0001529_abnormal_vocalization4.78194227
4MP0003880_abnormal_central_pattern4.30116620
5MP0006276_abnormal_autonomic_nervous4.23122402
6MP0004859_abnormal_synaptic_plasticity3.23115698
7MP0003635_abnormal_synaptic_transmissio2.80688303
8MP0003122_maternal_imprinting2.77418633
9MP0002139_abnormal_hepatobiliary_system2.76772538
10MP0002909_abnormal_adrenal_gland2.72968573
11MP0002733_abnormal_thermal_nociception2.69929824
12MP0005386_behavior/neurological_phenoty2.46227127
13MP0004924_abnormal_behavior2.46227127
14MP0009745_abnormal_behavioral_response2.43082841
15MP0002064_seizures2.40294563
16MP0002102_abnormal_ear_morphology2.39625098
17MP0009046_muscle_twitch2.36873867
18MP0001440_abnormal_grooming_behavior2.36866125
19MP0008872_abnormal_physiological_respon2.34120881
20MP0001970_abnormal_pain_threshold2.27392652
21MP0001968_abnormal_touch/_nociception2.22650309
22MP0003121_genomic_imprinting2.16020497
23MP0002735_abnormal_chemical_nociception2.12629599
24MP0005423_abnormal_somatic_nervous2.10064691
25MP0002734_abnormal_mechanical_nocicepti2.09377774
26MP0002572_abnormal_emotion/affect_behav2.08360779
27MP0001501_abnormal_sleep_pattern2.07339318
28MP0003787_abnormal_imprinting2.07163842
29MP0004270_analgesia2.05011363
30MP0002751_abnormal_autonomic_nervous2.03330770
31MP0000538_abnormal_urinary_bladder1.97952803
32MP0001188_hyperpigmentation1.96900639
33MP0002184_abnormal_innervation1.88498301
34MP0002736_abnormal_nociception_after1.86277943
35* MP0002063_abnormal_learning/memory/cond1.82337564
36MP0001664_abnormal_digestion1.76282059
37MP0002272_abnormal_nervous_system1.73870360
38MP0005409_darkened_coat_color1.71083748
39MP0002067_abnormal_sensory_capabilities1.69006745
40MP0005535_abnormal_body_temperature1.68528589
41MP0002837_dystrophic_cardiac_calcinosis1.67664624
42MP0010386_abnormal_urinary_bladder1.64742879
43MP0001486_abnormal_startle_reflex1.61978954
44MP0002638_abnormal_pupillary_reflex1.56242974
45MP0002332_abnormal_exercise_endurance1.51846909
46MP0000639_abnormal_adrenal_gland1.51764106
47MP0003567_abnormal_fetal_cardiomyocyte1.46816235
48MP0002557_abnormal_social/conspecific_i1.45591595
49MP0003868_abnormal_feces_composition1.43429990
50MP0008995_early_reproductive_senescence1.40176050
51MP0004133_heterotaxia1.30725636
52MP0008877_abnormal_DNA_methylation1.29953790
53MP0004858_abnormal_nervous_system1.26792713
54MP0000955_abnormal_spinal_cord1.25863988
55MP0000751_myopathy1.22242153
56MP0004885_abnormal_endolymph1.22232976
57MP0004811_abnormal_neuron_physiology1.18331921
58MP0000747_muscle_weakness1.18219554
59MP0002066_abnormal_motor_capabilities/c1.15421658
60MP0005646_abnormal_pituitary_gland1.12935062
61MP0002090_abnormal_vision1.11967094
62MP0000566_synostosis1.11837929
63MP0002163_abnormal_gland_morphology1.11300750
64MP0005379_endocrine/exocrine_gland_phen1.09589029
65MP0000778_abnormal_nervous_system1.07928311
66MP0001270_distended_abdomen1.03583649
67MP0000013_abnormal_adipose_tissue0.98853892
68MP0000569_abnormal_digit_pigmentation0.98159013
69MP0002882_abnormal_neuron_morphology0.97724027
70MP0005551_abnormal_eye_electrophysiolog0.97068317
71MP0001984_abnormal_olfaction0.96673907
72MP0003329_amyloid_beta_deposits0.94105434
73MP0004142_abnormal_muscle_tone0.93984463
74MP0003632_abnormal_nervous_system0.90296117
75MP0005248_abnormal_Harderian_gland0.90029694
76MP0003866_abnormal_defecation0.90012463
77MP0000631_abnormal_neuroendocrine_gland0.89329253
78MP0005253_abnormal_eye_physiology0.89247080
79MP0000026_abnormal_inner_ear0.86997318
80MP0008874_decreased_physiological_sensi0.86878024
81MP0008569_lethality_at_weaning0.84336631
82MP0005187_abnormal_penis_morphology0.84075378
83MP0000049_abnormal_middle_ear0.83574199
84MP0003890_abnormal_embryonic-extraembry0.82451858
85MP0003631_nervous_system_phenotype0.79768857
86MP0002069_abnormal_eating/drinking_beha0.79735275
87MP0005171_absent_coat_pigmentation0.78372465
88MP0001502_abnormal_circadian_rhythm0.78114791
89MP0000534_abnormal_ureter_morphology0.77820243
90MP0003315_abnormal_perineum_morphology0.76556757
91MP0006072_abnormal_retinal_apoptosis0.74683501
92MP0003861_abnormal_nervous_system0.72709125
93MP0004085_abnormal_heartbeat0.72191119
94MP0004742_abnormal_vestibular_system0.72138586
95MP0008961_abnormal_basal_metabolism0.72009001
96MP0004883_abnormal_blood_vessel0.70182087
97MP0003183_abnormal_peptide_metabolism0.69813266
98MP0001881_abnormal_mammary_gland0.68878882
99MP0002229_neurodegeneration0.67956177
100MP0003879_abnormal_hair_cell0.65793024
101MP0009379_abnormal_foot_pigmentation0.65684407
102MP0002152_abnormal_brain_morphology0.64713948
103MP0001963_abnormal_hearing_physiology0.64082760
104MP0003942_abnormal_urinary_system0.63779915
105MP0005083_abnormal_biliary_tract0.63235420
106MP0001324_abnormal_eye_pigmentation0.62681352
107MP0006035_abnormal_mitochondrial_morpho0.62557520
108MP0005195_abnormal_posterior_eye0.62190535
109MP0001340_abnormal_eyelid_morphology0.61813878
110MP0005499_abnormal_olfactory_system0.61523691
111MP0005394_taste/olfaction_phenotype0.61523691
112MP0000427_abnormal_hair_cycle0.61048288
113MP0002082_postnatal_lethality0.59804853
114MP0010770_preweaning_lethality0.59804853
115MP0008875_abnormal_xenobiotic_pharmacok0.59781783
116MP0003937_abnormal_limbs/digits/tail_de0.59593025
117MP0003633_abnormal_nervous_system0.59498617
118MP0003011_delayed_dark_adaptation0.58957365
119MP0000681_abnormal_thyroid_gland0.58754747
120MP0002752_abnormal_somatic_nervous0.57317845
121MP0001299_abnormal_eye_distance/0.54994659
122MP0005310_abnormal_salivary_gland0.54387046
123MP0002876_abnormal_thyroid_physiology0.53973742
124MP0003634_abnormal_glial_cell0.52464823
125MP0005645_abnormal_hypothalamus_physiol0.51787250
126MP0003638_abnormal_response/metabolism_0.51743944
127MP0004145_abnormal_muscle_electrophysio0.49503425

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)8.87298431
2Pheochromocytoma (HP:0002666)7.41009368
3Neuroendocrine neoplasm (HP:0100634)6.79494578
4Failure to thrive in infancy (HP:0001531)5.75437596
5Visual hallucinations (HP:0002367)5.57819679
6Potter facies (HP:0002009)5.29477363
7Facial shape deformation (HP:0011334)5.29477363
8Abnormal pupillary function (HP:0007686)4.79525794
9Akinesia (HP:0002304)4.60737594
10Myokymia (HP:0002411)4.60704616
11Hypoventilation (HP:0002791)4.46378186
12Cerebral hemorrhage (HP:0001342)4.27457067
13Hypercortisolism (HP:0001578)4.18881478
14Orthostatic hypotension (HP:0001278)4.12529927
15Abnormality of calcium-phosphate metabolism (HP:0100530)4.09190495
16Abnormality of the parathyroid morphology (HP:0011766)3.82844836
17Neoplasm of the peripheral nervous system (HP:0100007)3.66439344
18Postural instability (HP:0002172)3.63280064
19Limb hypertonia (HP:0002509)3.46734193
20Progressive cerebellar ataxia (HP:0002073)3.44016451
21Cerebral inclusion bodies (HP:0100314)3.43388349
22Postural tremor (HP:0002174)3.43211481
23Acute necrotizing encephalopathy (HP:0006965)3.33214012
24Delayed gross motor development (HP:0002194)3.32722260
25Abnormal autonomic nervous system physiology (HP:0012332)3.28984779
26Focal seizures (HP:0007359)3.27326208
27Drooling (HP:0002307)3.05507749
28Abnormal mitochondria in muscle tissue (HP:0008316)3.03257857
29Retinal dysplasia (HP:0007973)3.01506707
30Mitochondrial inheritance (HP:0001427)2.97792952
31Focal motor seizures (HP:0011153)2.97169219
32Hypsarrhythmia (HP:0002521)2.95574973
33EEG with generalized epileptiform discharges (HP:0011198)2.93294064
34Thyroid carcinoma (HP:0002890)2.92057754
35Gait imbalance (HP:0002141)2.90225498
36Progressive macrocephaly (HP:0004481)2.89221555
37Epileptiform EEG discharges (HP:0011182)2.87421366
38Morphological abnormality of the pyramidal tract (HP:0002062)2.85186942
39Agitation (HP:0000713)2.82635558
40Hyperparathyroidism (HP:0000843)2.82504666
41Excessive salivation (HP:0003781)2.80408072
42Hypotension (HP:0002615)2.79755860
43Decreased circulating renin level (HP:0003351)2.71668975
44Amyotrophic lateral sclerosis (HP:0007354)2.68265481
45Primitive neuroectodermal tumor (HP:0030065)2.65662595
46Neuroblastic tumors (HP:0004376)2.65662595
47Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.65662595
48Neuroblastoma (HP:0003006)2.65662595
49Genital tract atresia (HP:0001827)2.64837524
50Insidious onset (HP:0003587)2.63086000
51Termporal pattern (HP:0011008)2.63086000
52Mutism (HP:0002300)2.61729038
53Acute encephalopathy (HP:0006846)2.60693416
54Dysautonomia (HP:0002459)2.59548744
55Action tremor (HP:0002345)2.58694221
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57652193
57Vaginal atresia (HP:0000148)2.54661112
58Generalized tonic-clonic seizures (HP:0002069)2.54043527
59Delusions (HP:0000746)2.53702903
60Anxiety (HP:0000739)2.52109208
61* Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46172152
62Emotional lability (HP:0000712)2.44327956
63Dyskinesia (HP:0100660)2.43235890
64Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41858689
65Progressive inability to walk (HP:0002505)2.41619851
66Myotonia (HP:0002486)2.41604121
67Hepatocellular necrosis (HP:0001404)2.40952125
68* Diminished movement (HP:0002374)2.38411721
69Ulnar claw (HP:0001178)2.37498349
70Status epilepticus (HP:0002133)2.35513316
71Bradykinesia (HP:0002067)2.35389265
72Bicornuate uterus (HP:0000813)2.32228684
73Increased CSF lactate (HP:0002490)2.29849570
74Inability to walk (HP:0002540)2.29055912
75Atonic seizures (HP:0010819)2.28018164
76Adrenal overactivity (HP:0002717)2.27741984
77Aplasia/Hypoplasia of the brainstem (HP:0007362)2.27257068
78Hypoplasia of the brainstem (HP:0002365)2.27257068
79Absence seizures (HP:0002121)2.26672352
80Abnormality of midbrain morphology (HP:0002418)2.23072187
81Molar tooth sign on MRI (HP:0002419)2.23072187
82Acute lymphatic leukemia (HP:0006721)2.22265616
83* Rigidity (HP:0002063)2.21548716
84Amblyopia (HP:0000646)2.18744759
85* Muscular hypotonia of the trunk (HP:0008936)2.18565321
86Torticollis (HP:0000473)2.15430630
87Truncal ataxia (HP:0002078)2.13840805
88Broad-based gait (HP:0002136)2.13624054
89Cholecystitis (HP:0001082)2.13020349
90Abnormal gallbladder physiology (HP:0012438)2.13020349
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12211879
92Poor suck (HP:0002033)2.10619561
93Craniofacial dystonia (HP:0012179)2.10179375
94Lissencephaly (HP:0001339)2.08522649
95Supranuclear gaze palsy (HP:0000605)2.08318979
96Medial flaring of the eyebrow (HP:0010747)2.07978937
97Generalized myoclonic seizures (HP:0002123)2.07856806
98Depression (HP:0000716)2.07689496
99Type II lissencephaly (HP:0007260)2.07109506
100Impaired vibration sensation in the lower limbs (HP:0002166)2.07076045
101Febrile seizures (HP:0002373)2.05581566
102Congenital primary aphakia (HP:0007707)2.05463590
103Fetal akinesia sequence (HP:0001989)2.04989593
104Dialeptic seizures (HP:0011146)2.02026675
105Nephronophthisis (HP:0000090)2.00939860
106Goiter (HP:0000853)2.00537878
107Spastic tetraplegia (HP:0002510)2.00245499
108* Limb dystonia (HP:0002451)10.4196062
109Poor eye contact (HP:0000817)1.98938795
110Polyphagia (HP:0002591)1.98006686
111Abnormality of pain sensation (HP:0010832)1.97495106
112Impaired pain sensation (HP:0007328)1.97495106
113Nephrogenic diabetes insipidus (HP:0009806)1.97393924
114Focal dystonia (HP:0004373)1.94906526
115Cortical dysplasia (HP:0002539)1.94820377
116Esotropia (HP:0000565)1.93689737
117Abnormality of the corticospinal tract (HP:0002492)1.91342828
118Lipid accumulation in hepatocytes (HP:0006561)1.91258156
119Rapidly progressive (HP:0003678)1.90836861
120Abnormality of the vocal cords (HP:0008777)1.88773423
121Anosmia (HP:0000458)1.86083219
122Exotropia (HP:0000577)1.85923474
123Oligomenorrhea (HP:0000876)1.85007936
124Increased hepatocellular lipid droplets (HP:0006565)1.84685838
125Cerebral edema (HP:0002181)1.83533274
126Psychosis (HP:0000709)1.80966169
127Abnormal hair whorl (HP:0010721)1.80958856
128Hepatic necrosis (HP:0002605)1.80154958
129Gastroesophageal reflux (HP:0002020)1.79686060
130Optic disc pallor (HP:0000543)1.79059171
131Renal Fanconi syndrome (HP:0001994)1.76980352
132Impaired social interactions (HP:0000735)1.76562903
133Abnormal social behavior (HP:0012433)1.76562903
134Neonatal onset (HP:0003623)1.75953308
135Oligodactyly (hands) (HP:0001180)1.74564631
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.73524639
137Abnormality of salivation (HP:0100755)1.72272523
138Epileptic encephalopathy (HP:0200134)1.72182779
139Chronic hepatic failure (HP:0100626)1.72070457
140Specific learning disability (HP:0001328)1.71679783
141Hemiparesis (HP:0001269)1.69619597
142Abnormal eating behavior (HP:0100738)1.68535555
143Disproportionate tall stature (HP:0001519)1.67191142
144* Hypokinesia (HP:0002375)1.67002076
145* Myoclonus (HP:0001336)1.66734414
146Intestinal atresia (HP:0011100)1.66589185
147Ankle clonus (HP:0011448)1.66472327
148Labial hypoplasia (HP:0000066)1.66421813
149Sleep apnea (HP:0010535)1.63822567
150Genetic anticipation (HP:0003743)1.63449436
151Urinary urgency (HP:0000012)1.63391740
152Ventricular fibrillation (HP:0001663)1.63390216
153Neurofibrillary tangles (HP:0002185)1.63253635
154Restlessness (HP:0000711)1.62763749
155Testicular neoplasm (HP:0010788)1.62562417
156Renal dysplasia (HP:0000110)1.62326214
157Leukodystrophy (HP:0002415)1.61126728
158Pancreatic fibrosis (HP:0100732)1.60994077
159Diplopia (HP:0000651)1.60823480
160Abnormality of binocular vision (HP:0011514)1.60823480
161Hyperaldosteronism (HP:0000859)1.60552888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK54.70440044
2MAP3K124.52479207
3BUB13.60284670
4CSNK1G33.21676082
5NTRK13.16585055
6PNCK3.08657815
7PINK13.08276518
8GRK63.07408396
9CSNK1G22.92283131
10ARAF2.89608828
11MAP3K92.87867484
12ADRBK22.49380152
13PLK22.48454461
14MAP3K42.38672368
15CSNK1G12.32922375
16BCKDK2.31737324
17RET2.26724921
18MINK12.19754688
19MAP2K42.09849577
20NTRK32.05873900
21DYRK22.05189442
22PTK2B2.01541535
23FGR1.92260468
24WNK41.91840823
25MAP2K71.86115758
26LATS21.82512606
27STK391.78817574
28GRK71.62665281
29KSR21.62093184
30UHMK11.52276701
31TSSK61.49230833
32PTK21.40834771
33NTRK21.35418373
34MARK11.33482004
35MAP4K21.30219046
36NME11.27661432
37ADRBK11.26443359
38AKT31.18125479
39TNIK1.12924515
40CASK1.08549167
41ERBB31.07112386
42BMPR1B1.06363722
43* CAMK2A1.04506956
44MAPK130.99517192
45PKN10.99068977
46EPHA30.95692479
47PKN20.95230156
48TRIM280.93895316
49PRKCG0.93534431
50PHKG20.93394398
51PHKG10.93394398
52* CAMK2B0.91009345
53LMTK20.89918230
54* CDK50.89074846
55PAK60.88250503
56LIMK10.88182286
57MAP3K130.85674710
58PAK30.84467042
59MAP3K20.81822737
60DYRK1A0.80473093
61* CDK140.80034911
62MAP3K10.77486763
63MAP3K110.75294992
64MAP2K10.75110661
65DYRK1B0.74758479
66DYRK30.73403013
67* CDK180.73173363
68BRAF0.72048011
69* CDK150.70489532
70TLK10.70421073
71PLK30.69409282
72MATK0.68710861
73CAMKK10.67506328
74SGK20.67251720
75DAPK20.64867019
76MARK20.64110237
77FES0.64043797
78ERBB40.63481212
79SIK20.63318355
80* CDK11A0.60591466
81SCYL20.60491794
82CAMKK20.58889288
83TESK10.58835899
84MAP3K50.58666412
85MYLK0.58279571
86FLT30.56368528
87CAMK1G0.55471395
88WNK10.55042235
89SIK30.51808042
90CAMK1D0.51059326
91FER0.50203187
92PRKAA10.49988381
93SGK4940.49486288
94SGK2230.49486288
95SYK0.46609327
96MOS0.45021313
97TAOK30.44455881
98HIPK20.43377089
99INSRR0.43323170
100CAMK40.43255526
101SGK10.43043296
102MAPK150.41958283
103DAPK10.41478909
104* PRKACA0.40695897
105STK160.39570856
106RPS6KA20.38739497
107KSR10.38334375
108CSNK1E0.36278332
109PRKCE0.36060618
110TYRO30.34757902
111PRKCH0.33448550
112CSNK1A10.32573225
113PRKG10.31074114
114CSNK1A1L0.29733197
115DDR20.29342878
116EPHA40.29243122
117FYN0.28984937
118IGF1R0.28921611
119PRKCB0.28625386
120* CAMK2D0.27403429
121EPHB20.26657120
122WNK30.26538089
123BCR0.25796828
124OXSR10.25701241
125GRK10.24427105
126ROCK20.24061039
127CDK80.23506371
128SRC0.23459505
129PRKCZ0.22933792
130RAF10.22787491
131* CAMK2G0.22417700
132NEK10.22163632
133PRKCA0.22044781
134MAPK80.21655549
135CSNK1D0.20689265
136RIPK40.20318622

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.30297135
2Oxidative phosphorylation_Homo sapiens_hsa001903.97314566
3Parkinsons disease_Homo sapiens_hsa050123.94618439
4* Cocaine addiction_Homo sapiens_hsa050303.79636199
5Collecting duct acid secretion_Homo sapiens_hsa049663.15233607
6* Amphetamine addiction_Homo sapiens_hsa050312.83583263
7Phenylalanine metabolism_Homo sapiens_hsa003602.75122400
8Alzheimers disease_Homo sapiens_hsa050102.59560140
9* Dopaminergic synapse_Homo sapiens_hsa047282.56714916
10Nicotine addiction_Homo sapiens_hsa050332.27794473
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27244386
12Vibrio cholerae infection_Homo sapiens_hsa051102.25478039
13Serotonergic synapse_Homo sapiens_hsa047262.20860812
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.11114908
15Huntingtons disease_Homo sapiens_hsa050162.06168433
16* Tyrosine metabolism_Homo sapiens_hsa003501.99170132
17Cholinergic synapse_Homo sapiens_hsa047251.92124244
18Cardiac muscle contraction_Homo sapiens_hsa042601.82386206
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68986359
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63596254
21Insulin secretion_Homo sapiens_hsa049111.58080259
22Histidine metabolism_Homo sapiens_hsa003401.56350751
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53736657
24GABAergic synapse_Homo sapiens_hsa047271.53572735
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47440714
26Taste transduction_Homo sapiens_hsa047421.47368588
27Circadian entrainment_Homo sapiens_hsa047131.45977778
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42484458
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37832678
30Long-term potentiation_Homo sapiens_hsa047201.34004037
31Long-term depression_Homo sapiens_hsa047301.31089036
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28620220
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26178304
34Salivary secretion_Homo sapiens_hsa049701.25690053
35Olfactory transduction_Homo sapiens_hsa047401.25032455
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23374463
37Renin secretion_Homo sapiens_hsa049241.22854114
38Gap junction_Homo sapiens_hsa045401.20515396
39Glutamatergic synapse_Homo sapiens_hsa047241.19902253
40Morphine addiction_Homo sapiens_hsa050321.14877076
41* Alcoholism_Homo sapiens_hsa050341.07703512
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05208739
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03935350
44Thyroid cancer_Homo sapiens_hsa052161.00444968
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99005574
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97189595
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96977050
48Rheumatoid arthritis_Homo sapiens_hsa053230.96459237
49Calcium signaling pathway_Homo sapiens_hsa040200.94908622
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93405610
51Pyruvate metabolism_Homo sapiens_hsa006200.91188733
52GnRH signaling pathway_Homo sapiens_hsa049120.88881455
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88112566
54Basal transcription factors_Homo sapiens_hsa030220.85205767
55Gastric acid secretion_Homo sapiens_hsa049710.85129612
56Phagosome_Homo sapiens_hsa041450.83858508
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82276277
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79762499
59Proteasome_Homo sapiens_hsa030500.78379183
60Tryptophan metabolism_Homo sapiens_hsa003800.75829227
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75634817
62Thyroid hormone synthesis_Homo sapiens_hsa049180.75410067
63Estrogen signaling pathway_Homo sapiens_hsa049150.75103062
64Ether lipid metabolism_Homo sapiens_hsa005650.70925677
65African trypanosomiasis_Homo sapiens_hsa051430.68809812
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68675552
67Pancreatic secretion_Homo sapiens_hsa049720.66037955
68Fatty acid elongation_Homo sapiens_hsa000620.64869997
69Linoleic acid metabolism_Homo sapiens_hsa005910.64306704
70Oxytocin signaling pathway_Homo sapiens_hsa049210.64018339
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63629714
72Dorso-ventral axis formation_Homo sapiens_hsa043200.61817105
73Selenocompound metabolism_Homo sapiens_hsa004500.61643023
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59536233
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.54459665
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53037629
77Vitamin B6 metabolism_Homo sapiens_hsa007500.53026321
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52852119
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52800335
80Melanogenesis_Homo sapiens_hsa049160.50190776
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.49818981
82Bile secretion_Homo sapiens_hsa049760.49238055
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48505251
84Hedgehog signaling pathway_Homo sapiens_hsa043400.48028683
85Protein export_Homo sapiens_hsa030600.47491409
86Ras signaling pathway_Homo sapiens_hsa040140.45944947
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44946242
88Glucagon signaling pathway_Homo sapiens_hsa049220.44563769
89Sulfur metabolism_Homo sapiens_hsa009200.43505722
90Prion diseases_Homo sapiens_hsa050200.43135559
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.43084544
92Fatty acid biosynthesis_Homo sapiens_hsa000610.42939285
93ECM-receptor interaction_Homo sapiens_hsa045120.38719843
94cAMP signaling pathway_Homo sapiens_hsa040240.38652262
95Sphingolipid metabolism_Homo sapiens_hsa006000.38307267
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37622466
97Oocyte meiosis_Homo sapiens_hsa041140.37389048
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37262156
99Regulation of autophagy_Homo sapiens_hsa041400.33936021
100Circadian rhythm_Homo sapiens_hsa047100.32384238
101Steroid biosynthesis_Homo sapiens_hsa001000.31602854
102Type II diabetes mellitus_Homo sapiens_hsa049300.30913118
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29487138
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.29263199
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28199601
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27486770
107Butanoate metabolism_Homo sapiens_hsa006500.26212469
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25914814
109Axon guidance_Homo sapiens_hsa043600.25390214
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24510619
111Ovarian steroidogenesis_Homo sapiens_hsa049130.23991482
112ABC transporters_Homo sapiens_hsa020100.21994845
113* Metabolic pathways_Homo sapiens_hsa011000.21900464
114Endocytosis_Homo sapiens_hsa041440.21198542
115Salmonella infection_Homo sapiens_hsa051320.20693161
116Propanoate metabolism_Homo sapiens_hsa006400.19365354
117Starch and sucrose metabolism_Homo sapiens_hsa005000.19217974
118Insulin signaling pathway_Homo sapiens_hsa049100.18062677
119Phototransduction_Homo sapiens_hsa047440.17019208
120Dilated cardiomyopathy_Homo sapiens_hsa054140.15885958
121Mineral absorption_Homo sapiens_hsa049780.15727109
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15677448
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.15158276
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.14153439
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14094554
126MAPK signaling pathway_Homo sapiens_hsa040100.13252286
127ErbB signaling pathway_Homo sapiens_hsa040120.11896848
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.11286514
129Folate biosynthesis_Homo sapiens_hsa007900.11155540
130Glioma_Homo sapiens_hsa052140.10003669

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