ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein polyglutamylation (GO:0018095)	5.88322859
2	metallo-sulfur cluster assembly (GO:0031163)	5.41416370
3	iron-sulfur cluster assembly (GO:0016226)	5.41416370
4	nonmotile primary cilium assembly (GO:0035058)	5.25000993
5	regulation of cilium movement (GO:0003352)	5.01833479
6	positive regulation of growth hormone secretion (GO:0060124)	4.93063948
7	C21-steroid hormone biosynthetic process (GO:0006700)	4.58558996
8	pyrimidine dimer repair (GO:0006290)	4.56539298
9	protein localization to Golgi apparatus (GO:0034067)	4.53917285
10	sperm motility (GO:0030317)	4.48837820
11	epithelial cilium movement (GO:0003351)	4.38365723
12	C4-dicarboxylate transport (GO:0015740)	4.30474190
13	RNA destabilization (GO:0050779)	3.95358427
14	seminiferous tubule development (GO:0072520)	3.94221449
15	peptidyl-histidine modification (GO:0018202)	3.91723484
16	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.90780132
17	cilium or flagellum-dependent cell motility (GO:0001539)	3.90147346
18	positive regulation of endothelial cell differentiation (GO:0045603)	3.89824850
19	growth hormone secretion (GO:0030252)	3.87917113
20	protein insertion into membrane (GO:0051205)	3.84535424
21	alanine transport (GO:0032328)	3.81076204
22	acrosome reaction (GO:0007340)	3.75158381
23	RNA localization (GO:0006403)	3.73352954
24	dosage compensation (GO:0007549)	3.69711635
25	L-serine transport (GO:0015825)	3.64788219
26	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.58046633
27	ketone biosynthetic process (GO:0042181)	3.47139581
28	head development (GO:0060322)	3.44501951
29	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.40011018
30	ubiquinone metabolic process (GO:0006743)	3.37485561
31	cilium movement (GO:0003341)	3.34289290
32	maturation of 5.8S rRNA (GO:0000460)	3.31321514
33	ubiquinone biosynthetic process (GO:0006744)	3.25484141
34	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	3.24241540
35	spinal cord association neuron differentiation (GO:0021527)	3.23269651
36	phosphatidylethanolamine metabolic process (GO:0046337)	3.21360228
37	hair cell differentiation (GO:0035315)	3.18539823
38	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.15696636
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.15696636
40	regulation of growth hormone secretion (GO:0060123)	3.14977642
41	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.13758213
42	tRNA methylation (GO:0030488)	3.13278263
43	negative regulation of DNA recombination (GO:0045910)	3.11850325
44	chaperone-mediated protein transport (GO:0072321)	3.11609267
45	axoneme assembly (GO:0035082)	3.10572224
46	mannosylation (GO:0097502)	3.09878793
47	cilium morphogenesis (GO:0060271)	3.07652082
48	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.05764006
49	sialylation (GO:0097503)	3.05713753
50	mitotic cell cycle arrest (GO:0071850)	3.05591351
51	regulation of feeding behavior (GO:0060259)	3.00837283
52	histone mRNA catabolic process (GO:0071044)	3.00737502
53	quinone biosynthetic process (GO:1901663)	2.99968503
54	cholesterol biosynthetic process (GO:0006695)	2.99128685
55	serine transport (GO:0032329)	2.98609855
56	dendritic spine morphogenesis (GO:0060997)	2.97829795
57	positive regulation of mitochondrial fission (GO:0090141)	2.97325852
58	replication fork processing (GO:0031297)	2.97180012
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.96894772
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.95168668
61	sterol biosynthetic process (GO:0016126)	2.94014504
62	rRNA modification (GO:0000154)	2.91257410
63	regulation of microtubule-based movement (GO:0060632)	2.88233271
64	positive regulation of receptor biosynthetic process (GO:0010870)	2.88043196
65	photoreceptor cell maintenance (GO:0045494)	2.87266164
66	negative regulation of telomere maintenance (GO:0032205)	2.87184232
67	spermatid nucleus differentiation (GO:0007289)	2.87063005
68	pseudouridine synthesis (GO:0001522)	2.86487174
69	peptidyl-glutamic acid modification (GO:0018200)	2.86081253
70	intraciliary transport (GO:0042073)	2.86035803
71	behavioral response to nicotine (GO:0035095)	2.83065227
72	rRNA methylation (GO:0031167)	2.82188652
73	regulation of endothelial cell differentiation (GO:0045601)	2.81729419
74	microtubule severing (GO:0051013)	2.81030590
75	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.80940878
76	negative regulation of gene expression, epigenetic (GO:0045814)	2.80709612
77	acidic amino acid transport (GO:0015800)	2.79314744
78	DNA integration (GO:0015074)	2.78611517
79	protein-cofactor linkage (GO:0018065)	2.77796632
80	sperm-egg recognition (GO:0035036)	2.77486862
81	gamma-aminobutyric acid transport (GO:0015812)	2.76927729
82	chemosensory behavior (GO:0007635)	2.76435430
83	protein targeting to Golgi (GO:0000042)	2.76213563
84	mitochondrial RNA metabolic process (GO:0000959)	2.74881389
85	ncRNA catabolic process (GO:0034661)	2.73841029
86	RNA methylation (GO:0001510)	2.73188211
87	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.72012794
88	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71132969
89	tRNA modification (GO:0006400)	2.70592426
90	pyrimidine nucleotide catabolic process (GO:0006244)	2.70549109
91	isoprenoid biosynthetic process (GO:0008299)	2.68635099
92	establishment of protein localization to Golgi (GO:0072600)	2.67251197
93	microtubule polymerization or depolymerization (GO:0031109)	2.66977954
94	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.65391893
95	histone arginine methylation (GO:0034969)	2.64777583
96	embryonic skeletal joint morphogenesis (GO:0060272)	2.64372657
97	microtubule nucleation (GO:0007020)	2.64004191
98	DNA strand renaturation (GO:0000733)	2.62439366
99	binding of sperm to zona pellucida (GO:0007339)	2.61492085
100	L-glutamate transport (GO:0015813)	2.59970989

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.51541204
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.87406844
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.65436019
4	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.61767215
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.59254212
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.16030271
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.10167076
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.05087473
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.97652688
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.91617105
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.90894395
12	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.57060799
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.51750135
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.39763412
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.35377058
16	GABP_19822575_ChIP-Seq_HepG2_Human	2.31736737
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.31113242
18	IRF1_19129219_ChIP-ChIP_H3396_Human	2.18441408
19	XRN2_22483619_ChIP-Seq_HELA_Human	2.17217903
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.13674514
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.09554980
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.91247043
23	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.89697633
24	FUS_26573619_Chip-Seq_HEK293_Human	1.85079368
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.84278889
26	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.75076989
27	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.72811057
28	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.71345843
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.67700793
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.66759165
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.62414284
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.61442050
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60758946
34	CIITA_25753668_ChIP-Seq_RAJI_Human	1.57875165
35	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.55830330
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.55536600
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.54358709
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.50046160
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47222124
40	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.47147493
41	KDM5A_27292631_Chip-Seq_BREAST_Human	1.43568972
42	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.41430454
43	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.41139646
44	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.40784078
45	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.40415241
46	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.36149426
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33866701
48	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32662276
49	ERG_20517297_ChIP-Seq_VCAP_Human	1.29690448
50	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.28644582
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23294024
52	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.22724992
53	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.22560937
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.21949280
55	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.20445783
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.18249743
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.15536327
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.14174051
59	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.11836671
60	BCL6_27268052_Chip-Seq_Bcells_Human	1.11341600
61	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.09440328
62	OCT4_20526341_ChIP-Seq_ESCs_Human	1.08601484
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07287736
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.07287736
65	P68_20966046_ChIP-Seq_HELA_Human	1.06439704
66	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.05616276
67	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.05501325
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.03567661
69	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03499454
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.03286448
71	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03054585
72	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.02958438
73	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.02895679
74	ERA_21632823_ChIP-Seq_H3396_Human	1.02188666
75	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.02177761
76	AR_20517297_ChIP-Seq_VCAP_Human	1.02141267
77	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.02033228
78	GBX2_23144817_ChIP-Seq_PC3_Human	1.01839245
79	RAC3_21632823_ChIP-Seq_H3396_Human	1.01302950
80	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.98780444
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98759653
82	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.98758846
83	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98727888
84	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.98125419
85	PHF8_20622854_ChIP-Seq_HELA_Human	0.98082215
86	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97611421
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.96921687
88	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.96506401
89	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.93780892
90	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.93107961
91	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.92637394
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92632864
93	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.92516900
94	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.92332917
95	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.91823731
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.90671012
97	CTCF_21964334_Chip-Seq_Bcells_Human	0.90546522
98	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.90416014
99	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.89802105
100	NCOR_22424771_ChIP-Seq_293T_Human	0.89729777

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005248_abnormal_Harderian_gland	3.48673685
2	MP0005379_endocrine/exocrine_gland_phen	3.35006088
3	MP0008004_abnormal_stomach_pH	3.17521907
4	MP0001529_abnormal_vocalization	3.04889086
5	MP0002163_abnormal_gland_morphology	2.89942266
6	MP0005253_abnormal_eye_physiology	2.89777122
7	MP0005410_abnormal_fertilization	2.68993834
8	MP0004133_heterotaxia	2.48840430
9	MP0003878_abnormal_ear_physiology	2.44207095
10	MP0005377_hearing/vestibular/ear_phenot	2.44207095
11	MP0006072_abnormal_retinal_apoptosis	2.38195193
12	MP0006054_spinal_hemorrhage	2.33686045
13	MP0001986_abnormal_taste_sensitivity	2.29360805
14	MP0003880_abnormal_central_pattern	2.28094539
15	MP0006276_abnormal_autonomic_nervous	2.22842832
16	MP0008789_abnormal_olfactory_epithelium	2.22275696
17	MP0002653_abnormal_ependyma_morphology	2.17340624
18	MP0001984_abnormal_olfaction	2.16950565
19	MP0001764_abnormal_homeostasis	2.09322293
20	MP0000750_abnormal_muscle_regeneration	2.07952755
21	MP0008058_abnormal_DNA_repair	2.06462730
22	MP0003011_delayed_dark_adaptation	2.06392074
23	MP0005394_taste/olfaction_phenotype	2.02404365
24	MP0005499_abnormal_olfactory_system	2.02404365
25	MP0006292_abnormal_olfactory_placode	1.99698237
26	MP0005167_abnormal_blood-brain_barrier	1.88331177
27	MP0000631_abnormal_neuroendocrine_gland	1.77832958
28	MP0005670_abnormal_white_adipose	1.73562173
29	MP0005171_absent_coat_pigmentation	1.66509919
30	MP0005391_vision/eye_phenotype	1.66031076
31	MP0003698_abnormal_male_reproductive	1.60422773
32	MP0000778_abnormal_nervous_system	1.56632574
33	MP0005647_abnormal_sex_gland	1.53550009
34	MP0003122_maternal_imprinting	1.49504507
35	MP0001661_extended_life_span	1.46373972
36	MP0010368_abnormal_lymphatic_system	1.42312153
37	MP0001188_hyperpigmentation	1.41134827
38	MP0003119_abnormal_digestive_system	1.39043874
39	MP0002751_abnormal_autonomic_nervous	1.33036818
40	MP0000751_myopathy	1.27842683
41	MP0005551_abnormal_eye_electrophysiolog	1.25100805
42	MP0001929_abnormal_gametogenesis	1.24564353
43	MP0005187_abnormal_penis_morphology	1.24433984
44	MP0006035_abnormal_mitochondrial_morpho	1.23685786
45	MP0004859_abnormal_synaptic_plasticity	1.17616270
46	MP0010094_abnormal_chromosome_stability	1.16354805
47	MP0002735_abnormal_chemical_nociception	1.15488268
48	MP0003111_abnormal_nucleus_morphology	1.14906313
49	MP0008007_abnormal_cellular_replicative	1.12449663
50	MP0000026_abnormal_inner_ear	1.08997223
51	MP0001968_abnormal_touch/_nociception	1.08912338
52	MP0003077_abnormal_cell_cycle	1.08597828
53	MP0000681_abnormal_thyroid_gland	1.07393128
54	MP0004811_abnormal_neuron_physiology	1.06825398
55	MP0009697_abnormal_copulation	1.06271068
56	MP0001963_abnormal_hearing_physiology	1.04412436
57	MP0009046_muscle_twitch	1.01789093
58	MP0000647_abnormal_sebaceous_gland	1.01383208
59	MP0001919_abnormal_reproductive_system	1.00601700
60	MP0002090_abnormal_vision	1.00115588
61	MP0004233_abnormal_muscle_weight	0.99213359
62	MP0001486_abnormal_startle_reflex	0.97848177
63	MP0005084_abnormal_gallbladder_morpholo	0.95191262
64	MP0003787_abnormal_imprinting	0.94319055
65	MP0002736_abnormal_nociception_after	0.94267663
66	MP0002909_abnormal_adrenal_gland	0.92668731
67	MP0010234_abnormal_vibrissa_follicle	0.92328909
68	MP0002557_abnormal_social/conspecific_i	0.90926557
69	MP0002572_abnormal_emotion/affect_behav	0.90926033
70	MP0003137_abnormal_impulse_conducting	0.90115799
71	MP0008875_abnormal_xenobiotic_pharmacok	0.87564951
72	MP0002210_abnormal_sex_determination	0.87460010
73	MP0002638_abnormal_pupillary_reflex	0.87199315
74	MP0001293_anophthalmia	0.85982952
75	MP0002064_seizures	0.85317868
76	MP0003567_abnormal_fetal_cardiomyocyte	0.83842151
77	MP0000049_abnormal_middle_ear	0.83029418
78	MP0003136_yellow_coat_color	0.82561198
79	MP0002752_abnormal_somatic_nervous	0.82438425
80	MP0000955_abnormal_spinal_cord	0.82134088
81	MP0008995_early_reproductive_senescence	0.81468826
82	MP0002161_abnormal_fertility/fecundity	0.81346701
83	MP0005266_abnormal_metabolism	0.81020497
84	MP0000465_gastrointestinal_hemorrhage	0.80657613
85	MP0002332_abnormal_exercise_endurance	0.79302001
86	MP0000653_abnormal_sex_gland	0.79182001
87	MP0001145_abnormal_male_reproductive	0.77119424
88	MP0003186_abnormal_redox_activity	0.76863704
89	MP0008932_abnormal_embryonic_tissue	0.76803381
90	MP0002234_abnormal_pharynx_morphology	0.76222994
91	MP0005646_abnormal_pituitary_gland	0.76179680
92	MP0000358_abnormal_cell_content/	0.74382563
93	MP0003635_abnormal_synaptic_transmissio	0.73729859
94	MP0009745_abnormal_behavioral_response	0.72011883
95	MP0000747_muscle_weakness	0.71202743
96	MP0002092_abnormal_eye_morphology	0.70930339
97	MP0004142_abnormal_muscle_tone	0.70642824
98	MP0002269_muscular_atrophy	0.69743395
99	MP0002127_abnormal_cardiovascular_syste	0.68127410
100	MP0002067_abnormal_sensory_capabilities	0.67773352

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital primary aphakia (HP:0007707)	4.74842563
2	Gait imbalance (HP:0002141)	4.67113465
3	Medial flaring of the eyebrow (HP:0010747)	4.43018606
4	Nephrogenic diabetes insipidus (HP:0009806)	3.90519417
5	Chronic hepatic failure (HP:0100626)	3.89450693
6	Male infertility (HP:0003251)	3.85893518
7	Abnormal biliary tract physiology (HP:0012439)	3.32767830
8	Bile duct proliferation (HP:0001408)	3.32767830
9	Decreased testicular size (HP:0008734)	3.23421208
10	Poor coordination (HP:0002370)	3.22911839
11	Gonadotropin excess (HP:0000837)	3.19712660
12	Broad foot (HP:0001769)	3.15401052
13	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.09347954
14	Abnormal protein N-linked glycosylation (HP:0012347)	3.09347954
15	Abnormal protein glycosylation (HP:0012346)	3.09347954
16	Abnormal glycosylation (HP:0012345)	3.09347954
17	Vaginal atresia (HP:0000148)	3.06917517
18	Aplasia/hypoplasia of the uterus (HP:0008684)	3.05367602
19	Hypoplasia of the uterus (HP:0000013)	3.00942592
20	Nephronophthisis (HP:0000090)	2.95756704
21	Genital tract atresia (HP:0001827)	2.91193056
22	Thyroid-stimulating hormone excess (HP:0002925)	2.88797786
23	Aplasia/Hypoplasia of the lens (HP:0008063)	2.82411727
24	Type 2 muscle fiber atrophy (HP:0003554)	2.82162467
25	Entropion (HP:0000621)	2.81173822
26	Hypoplastic pelvis (HP:0008839)	2.75107814
27	Tubulointerstitial nephritis (HP:0001970)	2.69444315
28	Microvesicular hepatic steatosis (HP:0001414)	2.64405517
29	Abnormality of lateral ventricle (HP:0030047)	2.50915647
30	Poikiloderma (HP:0001029)	2.49335486
31	Abnormality of the renal medulla (HP:0100957)	2.45538421
32	Abnormality of DNA repair (HP:0003254)	2.45158506
33	3-Methylglutaconic aciduria (HP:0003535)	2.44546807
34	Pancreatic cysts (HP:0001737)	2.42764814
35	Muscle fiber atrophy (HP:0100295)	2.42002642
36	Abnormality of the parathyroid morphology (HP:0011766)	2.41786330
37	Neonatal respiratory distress (HP:0002643)	2.35927032
38	Type II lissencephaly (HP:0007260)	2.27491975
39	Progressive microcephaly (HP:0000253)	2.24693259
40	Abnormality of the hip-girdle musculature (HP:0001445)	2.23257919
41	Abnormality of the musculature of the pelvis (HP:0001469)	2.23257919
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.20013738
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.20013738
44	Specific learning disability (HP:0001328)	2.19724919
45	Adactyly (HP:0009776)	2.16712412
46	Polyphagia (HP:0002591)	2.16689679
47	Shoulder girdle muscle weakness (HP:0003547)	2.13143382
48	Pulmonary artery stenosis (HP:0004415)	2.12517382
49	Pancreatic islet-cell hyperplasia (HP:0004510)	2.07136004
50	Abnormality of midbrain morphology (HP:0002418)	2.06819278
51	Molar tooth sign on MRI (HP:0002419)	2.06819278
52	Short tibia (HP:0005736)	2.06092433
53	Exercise-induced muscle cramps (HP:0003710)	2.04563110
54	Postaxial hand polydactyly (HP:0001162)	2.02489880
55	Poor head control (HP:0002421)	2.00463974
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.00053308
57	Delayed epiphyseal ossification (HP:0002663)	1.97779866
58	Type I transferrin isoform profile (HP:0003642)	1.96491028
59	Attenuation of retinal blood vessels (HP:0007843)	1.96133635
60	Abnormality of the ileum (HP:0001549)	1.93087072
61	Atonic seizures (HP:0010819)	1.92372044
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91170401
63	Microretrognathia (HP:0000308)	1.86086807
64	Anterior segment dysgenesis (HP:0007700)	1.84173029
65	Acute hepatic failure (HP:0006554)	1.83586049
66	Dyskinesia (HP:0100660)	1.82466994
67	Stage 5 chronic kidney disease (HP:0003774)	1.81696583
68	Decreased central vision (HP:0007663)	1.81489859
69	Pelvic girdle muscle weakness (HP:0003749)	1.81178321
70	Left ventricular hypertrophy (HP:0001712)	1.79750574
71	True hermaphroditism (HP:0010459)	1.79425893
72	Aganglionic megacolon (HP:0002251)	1.78342715
73	Abnormal respiratory epithelium morphology (HP:0012253)	1.77143539
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77143539
75	Male pseudohermaphroditism (HP:0000037)	1.76032847
76	Growth hormone deficiency (HP:0000824)	1.75496086
77	Spastic diplegia (HP:0001264)	1.74937702
78	Prominent nasal bridge (HP:0000426)	1.74527493
79	Abnormality of the metopic suture (HP:0005556)	1.74439317
80	Asthma (HP:0002099)	1.74303572
81	Cortical dysplasia (HP:0002539)	1.73105456
82	Abnormal mitochondria in muscle tissue (HP:0008316)	1.71072572
83	Absent/shortened dynein arms (HP:0200106)	1.70116658
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.70116658
85	Acute necrotizing encephalopathy (HP:0006965)	1.68293406
86	Retinal dysplasia (HP:0007973)	1.68243146
87	Diastasis recti (HP:0001540)	1.67685496
88	Meckel diverticulum (HP:0002245)	1.67684497
89	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.67596477
90	Abnormality of alanine metabolism (HP:0010916)	1.67596477
91	Hyperalaninemia (HP:0003348)	1.67596477
92	Micropenis (HP:0000054)	1.67577795
93	Methylmalonic acidemia (HP:0002912)	1.67232567
94	Nephrotic syndrome (HP:0000100)	1.65963951
95	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.65389885
96	Abnormality of dental color (HP:0011073)	1.65160934
97	Insulin-resistant diabetes mellitus (HP:0000831)	1.64210724
98	Acute encephalopathy (HP:0006846)	1.64095968
99	Cone-rod dystrophy (HP:0000548)	1.64087630
100	Subcapsular cataract (HP:0000523)	1.63733539

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SRPK1	4.97255598
2	MAP4K2	4.96256026
3	DYRK1B	3.64535615
4	EPHA4	3.47204719
5	PLK4	3.14088003
6	PIM2	3.01522690
7	BCKDK	2.92112933
8	DYRK3	2.79902292
9	MAP3K4	2.77825046
10	MAPK15	2.65859417
11	RPS6KA4	2.15976047
12	MAP2K7	2.11456407
13	CDK6	2.07597985
14	CSNK1G3	1.99514653
15	CSNK1A1L	1.96183775
16	PLK2	1.84066154
17	WNK3	1.65337547
18	CSNK1G1	1.62795120
19	INSRR	1.58509432
20	DYRK2	1.57336087
21	EPHA3	1.53936229
22	MARK1	1.51070624
23	PINK1	1.40102144
24	CSNK1G2	1.38083304
25	EPHB1	1.32283264
26	TESK1	1.31812157
27	CDK19	1.20274963
28	UHMK1	1.10162326
29	MAP3K10	1.07553667
30	NUAK1	1.05607552
31	BRD4	1.03982913
32	PAK6	1.03437329
33	PASK	1.02781924
34	TESK2	0.99964877
35	TAOK3	0.99273068
36	DYRK1A	0.97110311
37	CDC7	0.94137151
38	LATS1	0.92771516
39	MAP3K11	0.92394791
40	MATK	0.91179227
41	MAP3K5	0.90866738
42	TNK2	0.88341342
43	FER	0.87499693
44	TXK	0.86020607
45	MAP2K4	0.85304816
46	TYRO3	0.75917871
47	PAK4	0.73738411
48	CASK	0.73686353
49	CSNK1A1	0.70589807
50	TIE1	0.70454294
51	AKT2	0.66548574
52	KDR	0.64956865
53	ERBB3	0.64423493
54	MAP3K6	0.63635352
55	ZAK	0.63036813
56	SGK494	0.62746575
57	SGK223	0.62746575
58	NEK6	0.57812378
59	STK16	0.57264997
60	CAMK4	0.54914788
61	MARK2	0.53961857
62	RPS6KA5	0.53203655
63	ATR	0.52659550
64	CDK3	0.48899916
65	DAPK2	0.48778917
66	ATM	0.48245464
67	BMX	0.48125972
68	DAPK3	0.45958755
69	PAK3	0.45532798
70	CDK5	0.42831843
71	TGFBR1	0.41343257
72	CAMK2A	0.41293725
73	PBK	0.39412561
74	SIK2	0.38878208
75	PRKCE	0.38431843
76	MAPK11	0.38322201
77	PKN1	0.37755086
78	MKNK1	0.37595883
79	CDK2	0.36647640
80	BMPR1B	0.36107403
81	NTRK3	0.35965851
82	CAMK2G	0.34233518
83	BCR	0.33596190
84	ADRBK2	0.33184700
85	TRIM28	0.31242169
86	TAOK1	0.31077219
87	CDK14	0.30855627
88	CAMK2D	0.30396757
89	PTK2B	0.28850882
90	CSNK2A1	0.26836033
91	TLK1	0.26769763
92	CAMK1	0.25696924
93	PRKACB	0.25408841
94	PLK1	0.25258768
95	CSNK1D	0.24989585
96	PRKACA	0.24934141
97	RPS6KA6	0.24666490
98	JAK2	0.23815306
99	FLT3	0.23686537
100	DDR2	0.22682425

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Steroid biosynthesis_Homo sapiens_hsa00100	4.34167857
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.52396387
3	Base excision repair_Homo sapiens_hsa03410	2.88266721
4	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.62173029
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.26586526
6	Sulfur relay system_Homo sapiens_hsa04122	2.25639591
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15534069
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.10272384
9	RNA transport_Homo sapiens_hsa03013	2.05599291
10	Non-homologous end-joining_Homo sapiens_hsa03450	1.96223523
11	RNA degradation_Homo sapiens_hsa03018	1.85128708
12	RNA polymerase_Homo sapiens_hsa03020	1.80888161
13	Taste transduction_Homo sapiens_hsa04742	1.78262678
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.74715007
15	Propanoate metabolism_Homo sapiens_hsa00640	1.73920570
16	Parkinsons disease_Homo sapiens_hsa05012	1.71980552
17	Fatty acid elongation_Homo sapiens_hsa00062	1.68786132
18	Nicotine addiction_Homo sapiens_hsa05033	1.67587062
19	Spliceosome_Homo sapiens_hsa03040	1.67110016
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.64389310
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.64073314
22	DNA replication_Homo sapiens_hsa03030	1.60891190
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.60342286
24	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.57899984
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.57219440
26	Phototransduction_Homo sapiens_hsa04744	1.55354071
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52182129
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.48976226
29	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.48636847
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.36143583
31	Homologous recombination_Homo sapiens_hsa03440	1.29045458
32	Huntingtons disease_Homo sapiens_hsa05016	1.28930129
33	Glycerolipid metabolism_Homo sapiens_hsa00561	1.27792459
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.27004748
35	Regulation of autophagy_Homo sapiens_hsa04140	1.22411748
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.21913739
37	Mismatch repair_Homo sapiens_hsa03430	1.20617932
38	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.18835042
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.18535554
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.18428712
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18374588
42	Protein export_Homo sapiens_hsa03060	1.17810060
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.16587341
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.13650552
45	mRNA surveillance pathway_Homo sapiens_hsa03015	1.12294873
46	Peroxisome_Homo sapiens_hsa04146	1.11375151
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10364916
48	Selenocompound metabolism_Homo sapiens_hsa00450	1.08521876
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.08428251
50	Fatty acid metabolism_Homo sapiens_hsa01212	1.07101689
51	Pyruvate metabolism_Homo sapiens_hsa00620	1.05884668
52	Arginine and proline metabolism_Homo sapiens_hsa00330	1.05819377
53	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.04751964
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.99273159
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.98312380
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98046784
57	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.97392224
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94316341
59	Metabolic pathways_Homo sapiens_hsa01100	0.94074264
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.90456725
61	Purine metabolism_Homo sapiens_hsa00230	0.88837327
62	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.88715834
63	GABAergic synapse_Homo sapiens_hsa04727	0.86966456
64	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.84553705
65	Olfactory transduction_Homo sapiens_hsa04740	0.81211397
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.81014556
67	Histidine metabolism_Homo sapiens_hsa00340	0.79360124
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.78222108
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78135524
70	Alzheimers disease_Homo sapiens_hsa05010	0.77415396
71	Fatty acid degradation_Homo sapiens_hsa00071	0.73054290
72	Butanoate metabolism_Homo sapiens_hsa00650	0.67808070
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67108156
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66704943
75	Morphine addiction_Homo sapiens_hsa05032	0.66567178
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66281353
77	One carbon pool by folate_Homo sapiens_hsa00670	0.64431287
78	Carbon metabolism_Homo sapiens_hsa01200	0.62047466
79	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.61287394
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61185814
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59301120
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59272765
83	Tryptophan metabolism_Homo sapiens_hsa00380	0.57017319
84	Ribosome_Homo sapiens_hsa03010	0.55239791
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.54924236
86	Renin-angiotensin system_Homo sapiens_hsa04614	0.47746982
87	Retinol metabolism_Homo sapiens_hsa00830	0.47682655
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43518334
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43368039
90	Basal transcription factors_Homo sapiens_hsa03022	0.42681363
91	Cardiac muscle contraction_Homo sapiens_hsa04260	0.42306137
92	Circadian entrainment_Homo sapiens_hsa04713	0.41782525
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41099476
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39694231
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.36891482
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.33883900
97	Proteasome_Homo sapiens_hsa03050	0.33778137
98	Axon guidance_Homo sapiens_hsa04360	0.33519609
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.32918994
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.27378102

THA1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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