THAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.55244320
2chaperone-mediated protein transport (GO:0072321)4.53534708
3protein neddylation (GO:0045116)4.42476547
4regulation of meiosis I (GO:0060631)4.32169535
5nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.27925816
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.15050720
7mitotic metaphase plate congression (GO:0007080)4.03826799
8protein K6-linked ubiquitination (GO:0085020)3.95640107
9CENP-A containing nucleosome assembly (GO:0034080)3.94798366
10rRNA modification (GO:0000154)3.87345213
11chromatin remodeling at centromere (GO:0031055)3.83237791
12DNA replication checkpoint (GO:0000076)3.82512442
13maturation of 5.8S rRNA (GO:0000460)3.81719823
14regulation of nuclear cell cycle DNA replication (GO:0033262)3.80498339
15kinetochore assembly (GO:0051382)3.75793821
16regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.73808956
17regulation of mitotic spindle checkpoint (GO:1903504)3.73808956
18kinetochore organization (GO:0051383)3.71376790
19attachment of spindle microtubules to kinetochore (GO:0008608)3.71129866
20regulation of double-strand break repair via homologous recombination (GO:0010569)3.61448462
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60888050
22proteasome assembly (GO:0043248)3.59297100
23meiotic chromosome segregation (GO:0045132)3.56750991
24telomere maintenance via semi-conservative replication (GO:0032201)3.52798900
25peptidyl-histidine modification (GO:0018202)3.49917215
26respiratory chain complex IV assembly (GO:0008535)3.49834203
27metaphase plate congression (GO:0051310)3.45061065
28RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.44910261
29negative regulation of ligase activity (GO:0051352)3.40047014
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40047014
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.39208054
32termination of RNA polymerase III transcription (GO:0006386)3.39208054
33telomere maintenance via recombination (GO:0000722)3.39028470
34ribosome biogenesis (GO:0042254)3.36572983
35resolution of meiotic recombination intermediates (GO:0000712)3.34991887
36DNA replication initiation (GO:0006270)3.34635119
37rRNA methylation (GO:0031167)3.32751984
38histone mRNA metabolic process (GO:0008334)3.32381668
39transcription from mitochondrial promoter (GO:0006390)3.30723470
40DNA replication-independent nucleosome assembly (GO:0006336)3.29315656
41DNA replication-independent nucleosome organization (GO:0034724)3.29315656
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28279669
43protein K11-linked ubiquitination (GO:0070979)3.23018540
44establishment of chromosome localization (GO:0051303)3.22468180
45histone exchange (GO:0043486)3.21672417
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19748647
47tachykinin receptor signaling pathway (GO:0007217)3.19183945
48negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.16618073
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15463993
50pseudouridine synthesis (GO:0001522)3.15289982
51nuclear pore organization (GO:0006999)3.14881132
52purine nucleobase biosynthetic process (GO:0009113)3.13189646
53regulation of mitochondrial translation (GO:0070129)3.12765270
54mitotic recombination (GO:0006312)3.11813820
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10584966
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10584966
57DNA strand elongation involved in DNA replication (GO:0006271)3.09767224
58replication fork processing (GO:0031297)3.09752615
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09246124
60microtubule depolymerization (GO:0007019)3.09059305
61telomere maintenance via telomere lengthening (GO:0010833)3.08319815
62negative regulation of DNA recombination (GO:0045910)3.08217412
63mitochondrial RNA metabolic process (GO:0000959)3.07917332
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07692087
65protein targeting to mitochondrion (GO:0006626)3.06151372
66DNA strand elongation (GO:0022616)3.04231290
67protein localization to mitochondrion (GO:0070585)3.03839545
68somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.03140937
69isotype switching (GO:0045190)3.03140937
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.03140937
71ribosomal small subunit assembly (GO:0000028)3.02195335
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01421825
73organelle disassembly (GO:1903008)3.01191922
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.00819863
75mitochondrial respiratory chain complex assembly (GO:0033108)3.00500575
76regulation of helicase activity (GO:0051095)2.98689416
77protein complex biogenesis (GO:0070271)2.98599114
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98199986
79spindle checkpoint (GO:0031577)2.97572173
80centriole replication (GO:0007099)2.97429405
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97348267
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97348267
83regulation of cellular amino acid metabolic process (GO:0006521)2.96388261
84energy coupled proton transport, down electrochemical gradient (GO:0015985)2.96330610
85ATP synthesis coupled proton transport (GO:0015986)2.96330610
86DNA synthesis involved in DNA repair (GO:0000731)2.94674049
87positive regulation of ligase activity (GO:0051351)2.94412731
88protein deneddylation (GO:0000338)2.93833187
89ribonucleoprotein complex biogenesis (GO:0022613)2.93709358
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93181101
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92962171
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92962171
93protein localization to kinetochore (GO:0034501)2.92814118
94termination of RNA polymerase I transcription (GO:0006363)2.92213599
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91397093
96negative regulation of sister chromatid segregation (GO:0033046)2.91397093
97negative regulation of mitotic sister chromatid separation (GO:2000816)2.91397093
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91397093
99DNA replication-dependent nucleosome organization (GO:0034723)2.91138706
100DNA replication-dependent nucleosome assembly (GO:0006335)2.91138706
101negative regulation of chromosome segregation (GO:0051985)2.90472943
102cytochrome complex assembly (GO:0017004)2.90249373
103establishment of integrated proviral latency (GO:0075713)2.88779755
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.88760432
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88760432
106nucleobase biosynthetic process (GO:0046112)2.88306178
107mitotic sister chromatid segregation (GO:0000070)2.87528047
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86575100
109rRNA processing (GO:0006364)2.86504781
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86461878
111spliceosomal snRNP assembly (GO:0000387)2.86344153
112signal transduction involved in cell cycle checkpoint (GO:0072395)2.85925266
113RNA capping (GO:0036260)2.85389682
1147-methylguanosine RNA capping (GO:0009452)2.85389682
115signal transduction involved in DNA damage checkpoint (GO:0072422)2.84297272
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84297272
117regulation of retinoic acid receptor signaling pathway (GO:0048385)2.83826764
118spindle assembly checkpoint (GO:0071173)2.83279147
119DNA double-strand break processing (GO:0000729)2.82747806
120nuclear pore complex assembly (GO:0051292)2.82718515
121regulation of telomere maintenance via telomerase (GO:0032210)2.82251385
122negative regulation of telomere maintenance (GO:0032205)2.81418524
123cullin deneddylation (GO:0010388)2.80997090
124rRNA metabolic process (GO:0016072)2.80709125
125regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80595598
1267-methylguanosine mRNA capping (GO:0006370)2.80527118
127protein localization to chromosome, centromeric region (GO:0071459)2.79690763
128negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77826263
129transcription from RNA polymerase I promoter (GO:0006360)2.76266722
130mitotic spindle assembly checkpoint (GO:0007094)2.76249331
131DNA catabolic process, exonucleolytic (GO:0000738)2.73834279
132maturation of SSU-rRNA (GO:0030490)2.73532304
133nucleotide-excision repair, DNA gap filling (GO:0006297)2.73336882
134exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73144368
135centriole assembly (GO:0098534)2.72964737
136regulation of mitotic metaphase/anaphase transition (GO:0030071)2.72426135
137ribosome assembly (GO:0042255)2.72015917
138regulation of centriole replication (GO:0046599)2.71591418
139DNA strand renaturation (GO:0000733)2.71428903
140mitotic spindle checkpoint (GO:0071174)2.70976237
141viral mRNA export from host cell nucleus (GO:0046784)2.70457691
142transcription elongation from RNA polymerase I promoter (GO:0006362)2.69358484
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69282768
144regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69043718
145positive regulation of DNA-dependent DNA replication (GO:2000105)2.68404301
146regulation of sister chromatid segregation (GO:0033045)2.66809754
147regulation of mitotic sister chromatid separation (GO:0010965)2.66809754
148regulation of mitotic sister chromatid segregation (GO:0033047)2.66809754
149tRNA methylation (GO:0030488)2.65783564
150piRNA metabolic process (GO:0034587)2.65446083
151reciprocal DNA recombination (GO:0035825)2.64220412
152reciprocal meiotic recombination (GO:0007131)2.64220412
153synapsis (GO:0007129)2.63070176
154tRNA modification (GO:0006400)2.62293412
155DNA-templated transcription, termination (GO:0006353)2.61834483
156signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61813607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.89149356
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72877919
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.61625068
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45815219
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39054644
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.38189081
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.36145457
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28068668
9* EST1_17652178_ChIP-ChIP_JURKAT_Human3.26610364
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.12390947
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.65826675
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58995258
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54711748
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54213391
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50658160
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46343214
17VDR_23849224_ChIP-Seq_CD4+_Human2.42936868
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40679135
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37853198
20ZNF274_21170338_ChIP-Seq_K562_Hela2.35642217
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26810579
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.19937791
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19015733
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14613142
25ELK1_19687146_ChIP-ChIP_HELA_Human2.09961470
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.08116911
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06024273
28FOXP3_21729870_ChIP-Seq_TREG_Human2.05526886
29IGF1R_20145208_ChIP-Seq_DFB_Human2.05243646
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04858562
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03913898
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00863887
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.95803675
34DCP1A_22483619_ChIP-Seq_HELA_Human1.95298740
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95108010
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94947586
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94284975
38EWS_26573619_Chip-Seq_HEK293_Human1.92386764
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90161171
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89777573
41* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89243645
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85020577
43* E2F1_21310950_ChIP-Seq_MCF-7_Human1.82427814
44VDR_22108803_ChIP-Seq_LS180_Human1.81905539
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79118346
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79102567
47* YY1_21170310_ChIP-Seq_MESCs_Mouse1.76451223
48XRN2_22483619_ChIP-Seq_HELA_Human1.76353524
49* GABP_19822575_ChIP-Seq_HepG2_Human1.74989763
50FUS_26573619_Chip-Seq_HEK293_Human1.70159246
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.69354924
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67180860
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65099830
54TTF2_22483619_ChIP-Seq_HELA_Human1.64664674
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63086759
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62670138
57* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61372687
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60319920
59TAF15_26573619_Chip-Seq_HEK293_Human1.59658684
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57663576
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56407735
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53680753
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53343902
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51763327
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43794577
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.43330849
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38166571
68AR_21909140_ChIP-Seq_LNCAP_Human1.37345654
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34505898
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33994604
71IRF1_19129219_ChIP-ChIP_H3396_Human1.33342610
72P300_19829295_ChIP-Seq_ESCs_Human1.30664544
73* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29675974
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.29331954
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26980201
76MYC_18940864_ChIP-ChIP_HL60_Human1.26704690
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24823522
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20724456
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20099411
80GBX2_23144817_ChIP-Seq_PC3_Human1.19157954
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18601208
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17155332
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13633354
84* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13063295
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11430476
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11302382
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.09711955
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06123905
89* NANOG_16153702_ChIP-ChIP_HESCs_Human1.05639942
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03745601
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.02429226
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00954362
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.00570467
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99949261
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99816778
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.98351927
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97699330
98HTT_18923047_ChIP-ChIP_STHdh_Human0.97553275
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97381288
100SALL4_22934838_ChIP-ChIP_CD34+_Human0.97246996
101ER_23166858_ChIP-Seq_MCF-7_Human0.97246422
102PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96800742
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96224768
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96199416
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95597001
106* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94530145
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93964310
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93793851
109KDM5A_27292631_Chip-Seq_BREAST_Human0.93224614
110* SPI1_23547873_ChIP-Seq_NB4_Human0.92270020
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90530740
112CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87512136
113TP53_22573176_ChIP-Seq_HFKS_Human0.86087682
114* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86054750
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85932711
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84402843
117CBP_20019798_ChIP-Seq_JUKART_Human0.83517795
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83517795
119TFEB_21752829_ChIP-Seq_HELA_Human0.81906669
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81393111
121CIITA_25753668_ChIP-Seq_RAJI_Human0.79776469
122* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77508332
123BP1_19119308_ChIP-ChIP_Hs578T_Human0.77159479
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76653489
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74687955
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74055589
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.73094870
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72766065
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72124849
130STAT4_19710469_ChIP-ChIP_TH1__Mouse0.71427786
131* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70394842
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70214697
133IRF8_22096565_ChIP-ChIP_GC-B_Human0.68382890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.52113167
2MP0008057_abnormal_DNA_replication3.79862479
3MP0008058_abnormal_DNA_repair3.78570115
4MP0006292_abnormal_olfactory_placode3.70366868
5MP0010094_abnormal_chromosome_stability3.68636080
6MP0003111_abnormal_nucleus_morphology3.56170595
7MP0008007_abnormal_cellular_replicative3.03436004
8MP0003077_abnormal_cell_cycle3.02583586
9MP0004957_abnormal_blastocyst_morpholog2.83830998
10MP0008877_abnormal_DNA_methylation2.64878305
11MP0001529_abnormal_vocalization2.42297795
12MP0003786_premature_aging2.39863910
13MP0008789_abnormal_olfactory_epithelium2.15482903
14MP0001188_hyperpigmentation2.12947678
15MP0003941_abnormal_skin_development2.06439224
16MP0003806_abnormal_nucleotide_metabolis2.05986445
17MP0008932_abnormal_embryonic_tissue2.04498017
18MP0003718_maternal_effect2.00231690
19MP0006036_abnormal_mitochondrial_physio1.98270633
20MP0002132_abnormal_respiratory_system1.92766417
21MP0002396_abnormal_hematopoietic_system1.92076400
22MP0003787_abnormal_imprinting1.81369391
23MP0006072_abnormal_retinal_apoptosis1.80077803
24MP0001835_abnormal_antigen_presentation1.68856092
25MP0000490_abnormal_crypts_of1.68682529
26MP0002736_abnormal_nociception_after1.67652051
27MP0000566_synostosis1.65041008
28MP0002210_abnormal_sex_determination1.62681504
29MP0009697_abnormal_copulation1.60786819
30MP0005499_abnormal_olfactory_system1.60378482
31MP0005394_taste/olfaction_phenotype1.60378482
32MP0001119_abnormal_female_reproductive1.56958664
33MP0005671_abnormal_response_to1.56664277
34MP0002163_abnormal_gland_morphology1.52031721
35MP0001929_abnormal_gametogenesis1.48255779
36MP0002160_abnormal_reproductive_system1.48141072
37MP0005075_abnormal_melanosome_morpholog1.46388931
38MP0002837_dystrophic_cardiac_calcinosis1.45156072
39MP0003950_abnormal_plasma_membrane1.45079514
40MP0006035_abnormal_mitochondrial_morpho1.44639291
41MP0009333_abnormal_splenocyte_physiolog1.40758082
42MP0001984_abnormal_olfaction1.40504759
43MP0005389_reproductive_system_phenotype1.39465190
44MP0002277_abnormal_respiratory_mucosa1.35188085
45MP0009785_altered_susceptibility_to1.32680522
46MP0008004_abnormal_stomach_pH1.30540101
47MP0004782_abnormal_surfactant_physiolog1.29921288
48MP0003763_abnormal_thymus_physiology1.28963751
49MP0001145_abnormal_male_reproductive1.28584132
50MP0000653_abnormal_sex_gland1.27157803
51MP0010386_abnormal_urinary_bladder1.25830016
52MP0000015_abnormal_ear_pigmentation1.25155640
53MP0000350_abnormal_cell_proliferation1.22856536
54MP0005253_abnormal_eye_physiology1.17884825
55MP0003121_genomic_imprinting1.15821368
56MP0000372_irregular_coat_pigmentation1.15567581
57MP0005171_absent_coat_pigmentation1.15361338
58MP0003011_delayed_dark_adaptation1.14582884
59MP0002148_abnormal_hypersensitivity_rea1.14499862
60MP0003186_abnormal_redox_activity1.13227767
61MP0003890_abnormal_embryonic-extraembry1.12635859
62MP0001545_abnormal_hematopoietic_system1.11994473
63MP0005397_hematopoietic_system_phenotyp1.11994473
64MP0002638_abnormal_pupillary_reflex1.10270729
65MP0005379_endocrine/exocrine_gland_phen1.09806979
66MP0004142_abnormal_muscle_tone1.09793637
67MP0000313_abnormal_cell_death1.09792333
68MP0005645_abnormal_hypothalamus_physiol1.09485687
69MP0002234_abnormal_pharynx_morphology1.09364156
70MP0003221_abnormal_cardiomyocyte_apopto1.08766366
71MP0000631_abnormal_neuroendocrine_gland1.07928376
72MP0003567_abnormal_fetal_cardiomyocyte1.07720034
73MP0002233_abnormal_nose_morphology1.07622190
74MP0002398_abnormal_bone_marrow1.06718829
75MP0004808_abnormal_hematopoietic_stem1.06090834
76MP0000858_altered_metastatic_potential1.05522489
77MP0000678_abnormal_parathyroid_gland1.05100775
78MP0003880_abnormal_central_pattern1.03725917
79MP0001968_abnormal_touch/_nociception0.99538474
80MP0005410_abnormal_fertilization0.99482887
81MP0004215_abnormal_myocardial_fiber0.99459900
82MP0001919_abnormal_reproductive_system0.99335814
83MP0010307_abnormal_tumor_latency0.99141016
84MP0000681_abnormal_thyroid_gland0.98995707
85MP0003436_decreased_susceptibility_to0.98974019
86MP0002019_abnormal_tumor_incidence0.98793612
87MP0002751_abnormal_autonomic_nervous0.98434648
88MP0002095_abnormal_skin_pigmentation0.98303634
89MP0000358_abnormal_cell_content/0.97978646
90MP0003698_abnormal_male_reproductive0.97739940
91MP0001986_abnormal_taste_sensitivity0.96908428
92MP0002938_white_spotting0.96416416
93MP0001764_abnormal_homeostasis0.94649002
94MP0001800_abnormal_humoral_immune0.94482254
95MP0000689_abnormal_spleen_morphology0.94081345
96MP0005551_abnormal_eye_electrophysiolog0.94020658
97MP0008995_early_reproductive_senescence0.93420058
98MP0005310_abnormal_salivary_gland0.91832940
99MP0005503_abnormal_tendon_morphology0.90281913
100MP0002452_abnormal_antigen_presenting0.89235752
101MP0001905_abnormal_dopamine_level0.88930905
102MP0000703_abnormal_thymus_morphology0.88640206
103MP0003136_yellow_coat_color0.88593601
104MP0001286_abnormal_eye_development0.88505536
105MP0003119_abnormal_digestive_system0.88330238
106MP0000427_abnormal_hair_cycle0.87821038
107MP0005000_abnormal_immune_tolerance0.87243850
108MP0006276_abnormal_autonomic_nervous0.87167510
109MP0003646_muscle_fatigue0.87056522
110MP0002722_abnormal_immune_system0.86501883
111MP0002420_abnormal_adaptive_immunity0.86183235
112MP0001819_abnormal_immune_cell0.85960654
113MP0000685_abnormal_immune_system0.85699984
114MP0005380_embryogenesis_phenotype0.85138064
115MP0001672_abnormal_embryogenesis/_devel0.85138064
116MP0002723_abnormal_immune_serum0.84316897
117MP0005248_abnormal_Harderian_gland0.84205277
118MP0000716_abnormal_immune_system0.84121570
119MP0002102_abnormal_ear_morphology0.81231607
120MP0002429_abnormal_blood_cell0.80636430
121MP0001293_anophthalmia0.79469465
122MP0002735_abnormal_chemical_nociception0.79240729
123MP0003123_paternal_imprinting0.79141405
124MP0001730_embryonic_growth_arrest0.77677154
125MP0002085_abnormal_embryonic_tissue0.77113717
126MP0003656_abnormal_erythrocyte_physiolo0.76855677
127MP0003943_abnormal_hepatobiliary_system0.76522667
128MP0003724_increased_susceptibility_to0.75237489
129MP0004145_abnormal_muscle_electrophysio0.75116072
130MP0005646_abnormal_pituitary_gland0.74840385
131MP0005084_abnormal_gallbladder_morpholo0.74704264
132MP0005423_abnormal_somatic_nervous0.74038130
133MP0002653_abnormal_ependyma_morphology0.73935718
134MP0005025_abnormal_response_to0.73229921
135MP0000049_abnormal_middle_ear0.72766429
136MP0005647_abnormal_sex_gland0.72673412
137MP0003699_abnormal_female_reproductive0.71848262
138MP0008872_abnormal_physiological_respon0.71561659
139MP0002090_abnormal_vision0.71533851
140MP0002876_abnormal_thyroid_physiology0.69328338
141MP0010352_gastrointestinal_tract_polyps0.69220609
142MP0008260_abnormal_autophagy0.69125709
143MP0003937_abnormal_limbs/digits/tail_de0.69111098
144MP0001542_abnormal_bone_strength0.68361675
145MP0005395_other_phenotype0.68310530
146MP0000647_abnormal_sebaceous_gland0.68279509
147MP0001697_abnormal_embryo_size0.68192840
148MP0005266_abnormal_metabolism0.66329262
149MP0009703_decreased_birth_body0.65768443
150MP0003195_calcinosis0.64488341
151MP0004133_heterotaxia0.63341371
152MP0002084_abnormal_developmental_patter0.63051737
153MP0005391_vision/eye_phenotype0.62854594

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.17356807
2Chromsome breakage (HP:0040012)4.93154081
3Acute necrotizing encephalopathy (HP:0006965)3.98364175
4Birth length less than 3rd percentile (HP:0003561)3.97890779
5Meckel diverticulum (HP:0002245)3.53181257
6Abnormal mitochondria in muscle tissue (HP:0008316)3.49761709
7Progressive macrocephaly (HP:0004481)3.48004050
8Acute encephalopathy (HP:0006846)3.43899573
9Abnormality of the preputium (HP:0100587)3.40890975
10Abnormality of the ileum (HP:0001549)3.40585586
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.35585591
12Mitochondrial inheritance (HP:0001427)3.35165807
13Increased hepatocellular lipid droplets (HP:0006565)3.24091977
14Increased CSF lactate (HP:0002490)3.24091574
15Patellar aplasia (HP:0006443)3.16829962
16Methylmalonic acidemia (HP:0002912)3.09905662
17Aplastic anemia (HP:0001915)3.09389291
18Abnormality of chromosome stability (HP:0003220)3.05204225
19Aplasia/Hypoplasia of the patella (HP:0006498)2.93733928
20Lipid accumulation in hepatocytes (HP:0006561)2.93655035
21Breast hypoplasia (HP:0003187)2.92126890
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88409119
23Colon cancer (HP:0003003)2.85997843
24Abnormality of the renal collecting system (HP:0004742)2.84907929
25Type I transferrin isoform profile (HP:0003642)2.82440830
26Reticulocytopenia (HP:0001896)2.81798800
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78076857
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78076857
29Rough bone trabeculation (HP:0100670)2.76335682
30Type 2 muscle fiber atrophy (HP:0003554)2.75023129
31Abnormality of midbrain morphology (HP:0002418)2.74707688
32Molar tooth sign on MRI (HP:0002419)2.74707688
33Duplicated collecting system (HP:0000081)2.72775582
34Small intestinal stenosis (HP:0012848)2.72544453
35Duodenal stenosis (HP:0100867)2.72544453
36Myelodysplasia (HP:0002863)2.69009853
37Cerebral edema (HP:0002181)2.64809724
38Abnormality of methionine metabolism (HP:0010901)2.64225915
39Increased serum lactate (HP:0002151)2.63382954
40Renal Fanconi syndrome (HP:0001994)2.62393816
41Bone marrow hypocellularity (HP:0005528)2.60447710
42Medial flaring of the eyebrow (HP:0010747)2.58561438
43Muscle fiber atrophy (HP:0100295)2.57306643
44Clubbing of toes (HP:0100760)2.55009616
45Abnormality of alanine metabolism (HP:0010916)2.54049763
46Hyperalaninemia (HP:0003348)2.54049763
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54049763
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54034643
49Ectopic kidney (HP:0000086)2.53206943
50Absent radius (HP:0003974)2.51358199
51Reduced antithrombin III activity (HP:0001976)2.49050217
52Increased IgM level (HP:0003496)2.48022527
53Carpal bone hypoplasia (HP:0001498)2.45078617
54Hepatocellular necrosis (HP:0001404)2.40862856
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38848823
56Impulsivity (HP:0100710)2.38493435
57Absent forearm bone (HP:0003953)2.35675868
58Aplasia involving forearm bones (HP:0009822)2.35675868
59Gonadotropin excess (HP:0000837)2.34803657
60Lactic acidosis (HP:0003128)2.32454212
61Methylmalonic aciduria (HP:0012120)2.31741452
62Hepatic necrosis (HP:0002605)2.30487371
63Microvesicular hepatic steatosis (HP:0001414)2.27193044
64Triphalangeal thumb (HP:0001199)2.25824636
65Facial cleft (HP:0002006)2.25307632
66Absent thumb (HP:0009777)2.24424640
67Abnormal spermatogenesis (HP:0008669)2.23911801
68Abnormality of serum amino acid levels (HP:0003112)2.23625791
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23312393
70Oral leukoplakia (HP:0002745)2.22635395
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.20425615
72Premature graying of hair (HP:0002216)2.20390080
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20210378
74Congenital primary aphakia (HP:0007707)2.19841836
75Abnormality of the duodenum (HP:0002246)2.19412025
76Prostate neoplasm (HP:0100787)2.15858586
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.15686035
78Hypoplasia of the fovea (HP:0007750)2.15686035
79Pancreatic fibrosis (HP:0100732)2.13745887
80Supernumerary spleens (HP:0009799)2.13278527
81Volvulus (HP:0002580)2.13177644
82Abnormality of the pons (HP:0007361)2.11802002
83Renal cortical cysts (HP:0000803)2.11198675
84Increased intramyocellular lipid droplets (HP:0012240)2.09788329
85Horseshoe kidney (HP:0000085)2.09435713
86Sloping forehead (HP:0000340)2.07758143
87Flat capital femoral epiphysis (HP:0003370)2.07654214
88Cleft eyelid (HP:0000625)2.07590172
89Abnormal trabecular bone morphology (HP:0100671)2.07538386
90Adrenal hypoplasia (HP:0000835)2.07481338
91Exercise intolerance (HP:0003546)2.06203222
92Increased serum pyruvate (HP:0003542)2.05858155
93Nephrogenic diabetes insipidus (HP:0009806)2.05375992
94Nephroblastoma (Wilms tumor) (HP:0002667)2.04477306
95Hyperglycinemia (HP:0002154)2.04022635
96Cellular immunodeficiency (HP:0005374)2.03943558
97Gait imbalance (HP:0002141)2.03268543
98Pancytopenia (HP:0001876)2.03209529
99Abnormality of the anterior horn cell (HP:0006802)2.03113781
100Degeneration of anterior horn cells (HP:0002398)2.03113781
10111 pairs of ribs (HP:0000878)2.02244632
102Abnormal respiratory motile cilium morphology (HP:0005938)2.02101231
103Abnormal respiratory epithelium morphology (HP:0012253)2.02101231
104Absent/shortened dynein arms (HP:0200106)2.01102566
105Dynein arm defect of respiratory motile cilia (HP:0012255)2.01102566
106Abnormal lung lobation (HP:0002101)2.00926368
107Abnormality of the labia minora (HP:0012880)1.99542372
108Stenosis of the external auditory canal (HP:0000402)1.98326309
109Respiratory failure (HP:0002878)1.95519525
110Abnormality of the prostate (HP:0008775)1.94833731
111Abnormal hair whorl (HP:0010721)1.94458349
112Pancreatic cysts (HP:0001737)1.94125352
113Abnormality of DNA repair (HP:0003254)1.94072093
114Embryonal renal neoplasm (HP:0011794)1.92565496
115Pulmonary fibrosis (HP:0002206)1.90819666
116Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90065589
117Median cleft lip (HP:0000161)1.89672149
118Abnormality of the vitamin B12 metabolism (HP:0004341)1.89462081
119Aplasia/hypoplasia of the uterus (HP:0008684)1.89178088
120Abnormality of vitamin B metabolism (HP:0004340)1.88635207
121Optic disc pallor (HP:0000543)1.88326612
122Exertional dyspnea (HP:0002875)1.87430967
123Abnormality of the septum pellucidum (HP:0007375)1.87425490
1243-Methylglutaconic aciduria (HP:0003535)1.86179811
125Sensory axonal neuropathy (HP:0003390)1.85829967
126Genital tract atresia (HP:0001827)1.85586322
127Poor suck (HP:0002033)1.84053898
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83216202
129Pancreatic islet-cell hyperplasia (HP:0004510)1.83181601
130Absent septum pellucidum (HP:0001331)1.83151960
131Lethargy (HP:0001254)1.81900358
132Leukodystrophy (HP:0002415)1.80927181
133Lymphoma (HP:0002665)1.80853349
134Hypergonadotropic hypogonadism (HP:0000815)1.80405782
135Intestinal atresia (HP:0011100)1.80018755
136Pendular nystagmus (HP:0012043)1.79840614
137Respiratory difficulties (HP:0002880)1.79529639
138X-linked dominant inheritance (HP:0001423)1.79260590
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78802681
140Abnormal protein N-linked glycosylation (HP:0012347)1.78802681
141Abnormal protein glycosylation (HP:0012346)1.78802681
142Abnormal glycosylation (HP:0012345)1.78802681
143Rhabdomyosarcoma (HP:0002859)1.77652037
144Posterior subcapsular cataract (HP:0007787)1.77554410
145Abnormality of macular pigmentation (HP:0008002)1.76887465
146Megaloblastic anemia (HP:0001889)1.76447837
147Azoospermia (HP:0000027)1.75953314
148Tracheoesophageal fistula (HP:0002575)1.74900499
149Short thumb (HP:0009778)1.74862163
150Irregular epiphyses (HP:0010582)1.74173779
151Abnormality of renal resorption (HP:0011038)1.72831608
152Glycosuria (HP:0003076)1.72465793
153Abnormality of urine glucose concentration (HP:0011016)1.72465793
154Capillary hemangiomas (HP:0005306)1.72396342
155Metaphyseal dysplasia (HP:0100255)1.71813696
156Vaginal atresia (HP:0000148)1.71378781
157Ependymoma (HP:0002888)1.71322330
158Abnormal number of erythroid precursors (HP:0012131)1.70115265
159Anencephaly (HP:0002323)1.70083323
160Preaxial hand polydactyly (HP:0001177)1.69820288
161Hypoplasia of the pons (HP:0012110)1.69768423
162Abnormal biliary tract physiology (HP:0012439)1.69454815
163Neoplasm of the adrenal cortex (HP:0100641)1.68486617
164Abnormality of the carotid arteries (HP:0005344)1.67758913
165Ureteral duplication (HP:0000073)1.67631674
166Abnormal respiratory motile cilium physiology (HP:0012261)1.66984673
167Cystic hygroma (HP:0000476)1.66105077
168Stomach cancer (HP:0012126)1.65084716
169Tongue fasciculations (HP:0001308)1.64778199
170Oligohydramnios (HP:0001562)1.63969031
171True hermaphroditism (HP:0010459)1.61628309
172Fibular aplasia (HP:0002990)1.61096380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.08750216
2BUB13.38948394
3SRPK13.15683813
4ZAK3.09696609
5TRIM283.04432685
6EIF2AK12.47253311
7WNK32.45943607
8STK162.39575138
9MAP3K42.34016557
10IRAK32.13677941
11WEE12.05998056
12EPHA21.99677131
13ACVR1B1.95177890
14TTK1.88342745
15AKT31.87763479
16PIM21.83182884
17STK38L1.77470206
18CDC71.76212998
19TNIK1.73712822
20CDK81.72483576
21NEK21.68322891
22PLK11.66634482
23VRK11.62738301
24DYRK31.60232498
25EIF2AK31.58945629
26CCNB11.58564348
27MKNK21.57819962
28TSSK61.54456600
29MAP4K21.53807074
30EIF2AK21.49256355
31MAP3K121.46191854
32IRAK41.46087064
33BMPR21.45296249
34CHEK21.44691875
35BRAF1.44679721
36CDK71.40762541
37ADRBK21.39074141
38NME21.36840212
39CASK1.35508680
40PIM11.35301820
41YES11.32508533
42TXK1.30834091
43VRK21.27964649
44MUSK1.27196178
45PLK31.26726755
46MAP3K141.25174658
47MKNK11.24513278
48ATR1.23103027
49ERBB31.22780059
50PINK11.21441958
51BRSK21.19248230
52PBK1.15559368
53MAP2K71.12458155
54TLK11.12144643
55FRK1.11773925
56GRK71.11124468
57IKBKB1.08412971
58TAF11.05274027
59CDK191.04156005
60STK241.02759826
61CDK121.01408611
62AURKB1.00798528
63BMPR1B0.99425261
64SIK30.98719924
65BCR0.98072041
66PASK0.95943608
67STK30.94416579
68PLK20.92919802
69RPS6KA40.90125238
70NLK0.88107138
71PRPF4B0.87270181
72LATS10.86332630
73CSNK1G10.84716606
74BRD40.83935437
75AURKA0.83168372
76CSNK1G20.82314949
77STK40.78871458
78TEC0.78846657
79NUAK10.78741964
80MAP3K60.77608298
81CHEK10.77275057
82CSNK1G30.77039883
83ERBB40.75413048
84BCKDK0.72963381
85TAOK20.72062008
86CHUK0.70918751
87MAPK130.70008187
88MELK0.68963659
89ATM0.67829400
90DYRK20.66828191
91NEK10.64179536
92BRSK10.60382399
93RAF10.58745837
94JAK30.58631364
95LIMK10.58179096
96PNCK0.58008161
97CAMKK20.56796801
98CSNK2A10.56146554
99CDK30.55989041
100NME10.55936676
101PAK30.53155481
102CSNK1A1L0.49207958
103RPS6KA50.48979448
104PDK20.48669525
105TAOK30.48193075
106PRKCG0.45428705
107TYK20.45317653
108SCYL20.44488799
109PIK3CA0.42983251
110CDK40.41044618
111RPS6KB20.40748235
112LATS20.39495271
113ABL20.38470255
114TESK20.37766138
115ARAF0.37695162
116CDK20.37385982
117GRK10.37353501
118NEK60.36963574
119PRKCQ0.36699256
120MARK30.36595325
121PRKCI0.35452996
122MAP2K40.35366636
123DMPK0.35232486
124MAP3K50.34087965
125LYN0.33198092
126CDK10.32982428
127KIT0.32958974
128TGFBR10.32932088
129OBSCN0.32265983
130IKBKE0.32150689
131IRAK10.31167838
132CLK10.30951387
133CSNK2A20.28658667
134PRKCE0.27778740
135OXSR10.26554652
136STK100.26090190
137MST40.25510663

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.77637265
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54360343
3RNA polymerase_Homo sapiens_hsa030203.51832418
4Proteasome_Homo sapiens_hsa030503.11285623
5Homologous recombination_Homo sapiens_hsa034403.08534030
6Mismatch repair_Homo sapiens_hsa034303.06705238
7Fanconi anemia pathway_Homo sapiens_hsa034602.94415584
8Base excision repair_Homo sapiens_hsa034102.82507289
9Spliceosome_Homo sapiens_hsa030402.69726892
10Ribosome_Homo sapiens_hsa030102.54379903
11Basal transcription factors_Homo sapiens_hsa030222.53729443
12Pyrimidine metabolism_Homo sapiens_hsa002402.53245841
13RNA transport_Homo sapiens_hsa030132.41396230
14Cell cycle_Homo sapiens_hsa041102.40206900
15Nucleotide excision repair_Homo sapiens_hsa034202.33383225
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20642488
17Non-homologous end-joining_Homo sapiens_hsa034502.18298324
18RNA degradation_Homo sapiens_hsa030182.14986138
19Fatty acid elongation_Homo sapiens_hsa000621.97305286
20One carbon pool by folate_Homo sapiens_hsa006701.96004477
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74120759
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68272114
23p53 signaling pathway_Homo sapiens_hsa041151.64777989
24Propanoate metabolism_Homo sapiens_hsa006401.60830907
25Purine metabolism_Homo sapiens_hsa002301.60572317
26Steroid biosynthesis_Homo sapiens_hsa001001.58807067
27Vitamin B6 metabolism_Homo sapiens_hsa007501.55847401
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54391608
29Alzheimers disease_Homo sapiens_hsa050101.46072275
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.44986870
31mRNA surveillance pathway_Homo sapiens_hsa030151.41941862
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38083832
33Protein export_Homo sapiens_hsa030601.35309934
34Herpes simplex infection_Homo sapiens_hsa051681.33384797
35Allograft rejection_Homo sapiens_hsa053301.32830213
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30503162
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.13287668
38Epstein-Barr virus infection_Homo sapiens_hsa051691.12438647
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11726449
40Collecting duct acid secretion_Homo sapiens_hsa049661.08093972
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04638745
42Pyruvate metabolism_Homo sapiens_hsa006201.04436783
43Graft-versus-host disease_Homo sapiens_hsa053321.04324714
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98256025
45Measles_Homo sapiens_hsa051620.95951535
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94873848
47Primary immunodeficiency_Homo sapiens_hsa053400.91769462
48Autoimmune thyroid disease_Homo sapiens_hsa053200.90583003
49Legionellosis_Homo sapiens_hsa051340.89911874
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89268708
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87317906
52Arachidonic acid metabolism_Homo sapiens_hsa005900.84960086
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81400442
54Systemic lupus erythematosus_Homo sapiens_hsa053220.80980478
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78770403
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76712636
57Antigen processing and presentation_Homo sapiens_hsa046120.75249920
58Type I diabetes mellitus_Homo sapiens_hsa049400.75178931
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73310191
60Hematopoietic cell lineage_Homo sapiens_hsa046400.73087313
61Cardiac muscle contraction_Homo sapiens_hsa042600.72198391
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71069788
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69164210
64Folate biosynthesis_Homo sapiens_hsa007900.67798317
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67607647
66Huntingtons disease_Homo sapiens_hsa050160.67076234
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65337380
68Asthma_Homo sapiens_hsa053100.65102086
69Influenza A_Homo sapiens_hsa051640.64668516
70Regulation of autophagy_Homo sapiens_hsa041400.64361079
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59622968
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59565838
73HTLV-I infection_Homo sapiens_hsa051660.59344212
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.59112282
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.58371930
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57852282
77Apoptosis_Homo sapiens_hsa042100.57851258
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.56163520
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54920005
80Peroxisome_Homo sapiens_hsa041460.54871243
81Sulfur metabolism_Homo sapiens_hsa009200.53186908
82Other glycan degradation_Homo sapiens_hsa005110.50762422
83Leishmaniasis_Homo sapiens_hsa051400.50335107
84Butanoate metabolism_Homo sapiens_hsa006500.49516595
85Fatty acid metabolism_Homo sapiens_hsa012120.49192093
86Rheumatoid arthritis_Homo sapiens_hsa053230.48205359
87Viral carcinogenesis_Homo sapiens_hsa052030.47680852
88Selenocompound metabolism_Homo sapiens_hsa004500.44444161
89Phototransduction_Homo sapiens_hsa047440.43585675
90TGF-beta signaling pathway_Homo sapiens_hsa043500.42942429
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41735890
92Pentose phosphate pathway_Homo sapiens_hsa000300.41684246
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40887398
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39664466
95Oocyte meiosis_Homo sapiens_hsa041140.39474595
96Hepatitis B_Homo sapiens_hsa051610.39397235
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39269592
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37212699
99Sphingolipid metabolism_Homo sapiens_hsa006000.36804337
100Tryptophan metabolism_Homo sapiens_hsa003800.35938283
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.35601148
102Nicotine addiction_Homo sapiens_hsa050330.34903252
103Caffeine metabolism_Homo sapiens_hsa002320.34689127
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33934496
105Circadian rhythm_Homo sapiens_hsa047100.33204179
106Acute myeloid leukemia_Homo sapiens_hsa052210.32076978
107Carbon metabolism_Homo sapiens_hsa012000.31976765
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31917503
109Sulfur relay system_Homo sapiens_hsa041220.31502084
110Linoleic acid metabolism_Homo sapiens_hsa005910.30055189
111Shigellosis_Homo sapiens_hsa051310.29311996
112Metabolic pathways_Homo sapiens_hsa011000.29305116
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29233712
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28937864
115Glutathione metabolism_Homo sapiens_hsa004800.26848597
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26776467
117Oxidative phosphorylation_Homo sapiens_hsa001900.26684658
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25856645
119Ether lipid metabolism_Homo sapiens_hsa005650.25362867
120TNF signaling pathway_Homo sapiens_hsa046680.25053925
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.24689452
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24469640
123Vitamin digestion and absorption_Homo sapiens_hsa049770.24273763
124Parkinsons disease_Homo sapiens_hsa050120.23693644
125FoxO signaling pathway_Homo sapiens_hsa040680.22884649
126MicroRNAs in cancer_Homo sapiens_hsa052060.22462877
127beta-Alanine metabolism_Homo sapiens_hsa004100.21979408
128Malaria_Homo sapiens_hsa051440.21522349
129N-Glycan biosynthesis_Homo sapiens_hsa005100.19644262
130Vibrio cholerae infection_Homo sapiens_hsa051100.19560858
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19332844
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16818082
133Notch signaling pathway_Homo sapiens_hsa043300.15462047
134Chemical carcinogenesis_Homo sapiens_hsa052040.14900832
135Basal cell carcinoma_Homo sapiens_hsa052170.14610559
136Thyroid cancer_Homo sapiens_hsa052160.14610237
137Wnt signaling pathway_Homo sapiens_hsa043100.12979835
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11924480
139Retinol metabolism_Homo sapiens_hsa008300.11266550
140Arginine and proline metabolism_Homo sapiens_hsa003300.09414252

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