THAP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.19106232
2mitotic metaphase plate congression (GO:0007080)4.88061668
3DNA deamination (GO:0045006)4.38800570
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.32312635
5protein localization to kinetochore (GO:0034501)4.27021141
6regulation of retinoic acid receptor signaling pathway (GO:0048385)4.25539438
7DNA replication checkpoint (GO:0000076)4.22183387
8DNA replication initiation (GO:0006270)4.21879536
9maturation of SSU-rRNA (GO:0030490)4.20892239
10formation of translation preinitiation complex (GO:0001731)4.19254259
11DNA unwinding involved in DNA replication (GO:0006268)4.14327519
12metaphase plate congression (GO:0051310)4.06670562
13DNA strand elongation involved in DNA replication (GO:0006271)4.03625742
14nucleobase biosynthetic process (GO:0046112)3.95815641
15folic acid-containing compound biosynthetic process (GO:0009396)3.95362019
16protein localization to chromosome, centromeric region (GO:0071459)3.94363598
17mitotic chromosome condensation (GO:0007076)3.92433050
18purine nucleobase biosynthetic process (GO:0009113)3.87625473
19regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.82000883
20ribosomal small subunit assembly (GO:0000028)3.81489812
21regulation of spindle organization (GO:0090224)3.79913781
22DNA strand elongation (GO:0022616)3.77374030
23mitotic nuclear envelope disassembly (GO:0007077)3.76057172
24ribosome biogenesis (GO:0042254)3.70360664
25DNA replication-dependent nucleosome assembly (GO:0006335)3.65265387
26DNA replication-dependent nucleosome organization (GO:0034723)3.65265387
27establishment of chromosome localization (GO:0051303)3.64045074
28protein complex localization (GO:0031503)3.63414072
29ribosome assembly (GO:0042255)3.62530634
30negative regulation of erythrocyte differentiation (GO:0045647)3.58200649
31folic acid metabolic process (GO:0046655)3.56062703
32mitotic sister chromatid segregation (GO:0000070)3.54466734
33CENP-A containing nucleosome assembly (GO:0034080)3.52825343
34nuclear envelope disassembly (GO:0051081)3.52282746
35membrane disassembly (GO:0030397)3.52282746
36translational termination (GO:0006415)3.51045882
37viral transcription (GO:0019083)3.50036340
38chromatin remodeling at centromere (GO:0031055)3.49986496
39DNA replication-independent nucleosome organization (GO:0034724)3.46883729
40DNA replication-independent nucleosome assembly (GO:0006336)3.46883729
413-UTR-mediated mRNA stabilization (GO:0070935)3.45250609
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43086552
43translational initiation (GO:0006413)3.42484569
44ribonucleoprotein complex biogenesis (GO:0022613)3.41232811
45protein K6-linked ubiquitination (GO:0085020)3.39413332
46telomere maintenance via semi-conservative replication (GO:0032201)3.37015323
47translational elongation (GO:0006414)3.36923237
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33574386
49regulation of chromosome segregation (GO:0051983)3.33527096
50spliceosomal snRNP assembly (GO:0000387)3.30812970
51protein localization to chromosome (GO:0034502)3.27867799
52negative regulation of chromosome segregation (GO:0051985)3.27028003
53attachment of spindle microtubules to kinetochore (GO:0008608)3.24492750
54spindle checkpoint (GO:0031577)3.22985864
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22971273
56negative regulation of sister chromatid segregation (GO:0033046)3.22971273
57negative regulation of mitotic sister chromatid separation (GO:2000816)3.22971273
58negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22971273
59negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.22914607
60mitochondrial DNA metabolic process (GO:0032042)3.21478387
61maturation of 5.8S rRNA (GO:0000460)3.20516395
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20322935
63negative regulation of cell killing (GO:0031342)3.20322935
64mitotic spindle assembly checkpoint (GO:0007094)3.20012540
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18697245
66ribosomal small subunit biogenesis (GO:0042274)3.16189204
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15256883
68ribosomal large subunit biogenesis (GO:0042273)3.15164481
69pentose-phosphate shunt (GO:0006098)3.14780368
70spindle assembly checkpoint (GO:0071173)3.14292926
71chromatin assembly or disassembly (GO:0006333)3.13773487
72rRNA processing (GO:0006364)3.10649960
73regulation of exit from mitosis (GO:0007096)3.10587959
74regulation of mammary gland epithelial cell proliferation (GO:0033599)3.10414144
75regulation of chromatin binding (GO:0035561)3.08549100
76histone H2A monoubiquitination (GO:0035518)3.08159503
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06636509
78sister chromatid segregation (GO:0000819)3.06332424
79mitotic spindle checkpoint (GO:0071174)3.05907895
80rRNA modification (GO:0000154)3.05110611
81histone exchange (GO:0043486)3.04646180
82rRNA metabolic process (GO:0016072)3.03819661
83proline biosynthetic process (GO:0006561)3.03250444
84peptidyl-arginine omega-N-methylation (GO:0035247)3.00034919
85iron-sulfur cluster assembly (GO:0016226)2.99796743
86metallo-sulfur cluster assembly (GO:0031163)2.99796743
87regulation of mitotic spindle organization (GO:0060236)2.99759034
88positive regulation of chromosome segregation (GO:0051984)2.98794323
89nuclear envelope organization (GO:0006998)2.97161496
90telomere maintenance via recombination (GO:0000722)2.97129364
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96934660
92histone arginine methylation (GO:0034969)2.95708427
93pyrimidine nucleotide catabolic process (GO:0006244)2.95684673
94regulation of sister chromatid cohesion (GO:0007063)2.94060235
95regulation of posttranscriptional gene silencing (GO:0060147)2.93480687
96regulation of gene silencing by miRNA (GO:0060964)2.93480687
97regulation of gene silencing by RNA (GO:0060966)2.93480687
98negative regulation of DNA-templated transcription, elongation (GO:0032785)2.93148241
99negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.93148241
100spliceosomal tri-snRNP complex assembly (GO:0000244)2.92217870
101pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88010112
102IMP biosynthetic process (GO:0006188)2.87346832
103regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86326953
104negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86152269
105pinocytosis (GO:0006907)2.86119518
106protein targeting to ER (GO:0045047)2.86102644
107cotranslational protein targeting to membrane (GO:0006613)2.85473739
108regulation of double-strand break repair via homologous recombination (GO:0010569)2.85238673
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83857121
110monoubiquitinated protein deubiquitination (GO:0035520)2.83695355
111negative regulation of histone methylation (GO:0031061)2.83194205
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82855557
113hyperosmotic salinity response (GO:0042538)2.82680477
114pseudouridine synthesis (GO:0001522)2.82554550
115DNA damage response, signal transduction resulting in transcription (GO:0042772)2.81736828
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81696097
117ATP-dependent chromatin remodeling (GO:0043044)2.80782189
118NADPH regeneration (GO:0006740)2.80455011
119protein K11-linked ubiquitination (GO:0070979)2.79915132
120IMP metabolic process (GO:0046040)2.78168667
121telomere maintenance via telomere lengthening (GO:0010833)2.77913767
122cellular protein complex disassembly (GO:0043624)2.77633275
123mitotic recombination (GO:0006312)2.77460048
124negative regulation of necrotic cell death (GO:0060547)2.72142194
125negative regulation of mRNA processing (GO:0050686)2.71867034
126protein maturation by protein folding (GO:0022417)2.68084390
127viral life cycle (GO:0019058)2.68052102
128mitochondrial DNA replication (GO:0006264)2.63822060
129rRNA transcription (GO:0009303)2.62052682
130negative regulation of mRNA metabolic process (GO:1903312)2.61743971
131negative regulation of necroptotic process (GO:0060546)2.61106271
132mitochondrial calcium ion transport (GO:0006851)2.60097955
133mucosal-associated lymphoid tissue development (GO:0048537)2.58596554
134Peyers patch development (GO:0048541)2.58596554
135regulation of mitochondrial translation (GO:0070129)2.56547184
136negative regulation of RNA splicing (GO:0033119)2.56486132
137modulation by virus of host process (GO:0019054)2.53973315
138peptidyl-arginine methylation (GO:0018216)2.52207546
139peptidyl-arginine N-methylation (GO:0035246)2.52207546
140positive regulation of systemic arterial blood pressure (GO:0003084)2.49215249
141antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49146641
142transcription from mitochondrial promoter (GO:0006390)2.48520201
143cellular protein complex localization (GO:0034629)2.46552250
144antigen processing and presentation of endogenous antigen (GO:0019883)2.46223376
145positive regulation of gamma-delta T cell activation (GO:0046645)2.45489357
146nucleotide salvage (GO:0043173)2.44357894
147protein complex disassembly (GO:0043241)2.41094196
148DNA synthesis involved in DNA repair (GO:0000731)2.40232983
149antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.39175843
150mitochondrial fusion (GO:0008053)2.36916686
151glucose catabolic process (GO:0006007)2.36064859
152cellular response to interleukin-4 (GO:0071353)2.34381170
153chromatin assembly (GO:0031497)2.31556751
154pyrimidine-containing compound salvage (GO:0008655)2.31291427
155pyrimidine nucleoside salvage (GO:0043097)2.31291427
156positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.29352743
157RNA stabilization (GO:0043489)2.28446252
158mRNA stabilization (GO:0048255)2.28446252
159neutrophil activation involved in immune response (GO:0002283)2.28263366
160viral mRNA export from host cell nucleus (GO:0046784)2.28253291
161UV protection (GO:0009650)2.27269386
162protein localization to endoplasmic reticulum (GO:0070972)2.24904896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.77304438
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.31555557
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96000907
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81381826
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09470474
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88287524
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76985761
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70200656
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.69289141
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67128308
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60153899
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60011256
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.58568208
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.45165025
15XRN2_22483619_ChIP-Seq_HELA_Human2.43857750
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41608142
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22292900
18* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19149244
19MYC_22102868_ChIP-Seq_BL_Human2.18661535
20AR_21909140_ChIP-Seq_LNCAP_Human2.18231375
21GABP_19822575_ChIP-Seq_HepG2_Human2.06505667
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00962304
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95655410
24VDR_23849224_ChIP-Seq_CD4+_Human1.94628233
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89403059
26* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85418555
27DCP1A_22483619_ChIP-Seq_HELA_Human1.85409353
28CIITA_25753668_ChIP-Seq_RAJI_Human1.80320551
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78886099
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.77653094
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74664008
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.72729387
33* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71943983
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70250145
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66765679
36* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61250058
37* TTF2_22483619_ChIP-Seq_HELA_Human1.60963886
38KDM5A_27292631_Chip-Seq_BREAST_Human1.59922735
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59083372
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57816050
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56513863
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56404465
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55940033
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55804695
45* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55638759
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55083905
47LXR_22292898_ChIP-Seq_THP-1_Human1.51856671
48MAF_26560356_Chip-Seq_TH1_Human1.51441581
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.50928646
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46070227
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45917008
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44536580
53TCF7_22412390_ChIP-Seq_EML_Mouse1.43286694
54UTX_26944678_Chip-Seq_JUKART_Human1.42921503
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.42881686
56SCL_19346495_ChIP-Seq_HPC-7_Human1.41131048
57MAF_26560356_Chip-Seq_TH2_Human1.40450889
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40247165
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.38611883
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38608400
61* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38235211
62VDR_21846776_ChIP-Seq_THP-1_Human1.36242211
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35542094
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35483376
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.34578416
66* KDM2B_26808549_Chip-Seq_DND41_Human1.33436609
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33066756
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32392688
69VDR_24763502_ChIP-Seq_THP-1_Human1.31483672
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30251307
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30237597
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29339468
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29311622
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28832776
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27727695
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27673031
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26684334
78ZNF263_19887448_ChIP-Seq_K562_Human1.25843583
79NCOR1_26117541_ChIP-Seq_K562_Human1.24924045
80* RACK7_27058665_Chip-Seq_MCF-7_Human1.23668973
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23335163
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23294706
83* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23255914
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22933863
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21532290
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21311385
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20702034
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19024808
89* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18290694
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.18146555
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17907846
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.16396259
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15324310
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14766682
95* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14426946
96SPI1_23547873_ChIP-Seq_NB4_Human1.13666210
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13482445
98TFEB_21752829_ChIP-Seq_HELA_Human1.13008823
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12925641
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12649672
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12267783
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11519590
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10707260
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10219089
105* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10171525
106SRF_21415370_ChIP-Seq_HL-1_Mouse1.09598933
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09551938
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07288109
109* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06373807
110RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05237772
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04004504
112ATF3_27146783_Chip-Seq_COLON_Human1.03783620
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.03601917
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02818161
115NANOG_21062744_ChIP-ChIP_HESCs_Human1.01417507
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98584822
117* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97379927
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97249543
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96496911
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95238272
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94766263
122MYC_18940864_ChIP-ChIP_HL60_Human0.93205668
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90982919
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90497519
125* FOXP1_21924763_ChIP-Seq_HESCs_Human0.90233594
126ELK1_19687146_ChIP-ChIP_HELA_Human0.89483914
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88575824
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88136921
129TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86706382
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86389460
131SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85167743
132* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82977051
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82173384
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.81297302
135ELK3_25401928_ChIP-Seq_HUVEC_Human0.81192079
136P68_20966046_ChIP-Seq_HELA_Human0.80859339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.23797395
2MP0004957_abnormal_blastocyst_morpholog4.62460118
3MP0003111_abnormal_nucleus_morphology4.40128735
4MP0003077_abnormal_cell_cycle4.00859661
5MP0010094_abnormal_chromosome_stability3.88416486
6MP0003123_paternal_imprinting3.50573748
7MP0005464_abnormal_platelet_physiology3.11373818
8MP0003763_abnormal_thymus_physiology2.90703255
9MP0001730_embryonic_growth_arrest2.79516131
10MP0008007_abnormal_cellular_replicative2.50121412
11MP0008058_abnormal_DNA_repair2.42021719
12* MP0008932_abnormal_embryonic_tissue2.21372812
13MP0000350_abnormal_cell_proliferation2.20039518
14MP0008877_abnormal_DNA_methylation2.12858978
15MP0008057_abnormal_DNA_replication2.06967001
16MP0001697_abnormal_embryo_size2.00976730
17MP0003718_maternal_effect1.94480809
18MP0001672_abnormal_embryogenesis/_devel1.94454644
19MP0005380_embryogenesis_phenotype1.94454644
20MP0002653_abnormal_ependyma_morphology1.91812437
21MP0003436_decreased_susceptibility_to1.89670167
22MP0003303_peritoneal_inflammation1.83845969
23MP0003567_abnormal_fetal_cardiomyocyte1.81919049
24MP0005058_abnormal_lysosome_morphology1.79669196
25MP0002085_abnormal_embryonic_tissue1.79068267
26* MP0002080_prenatal_lethality1.78909670
27MP0003984_embryonic_growth_retardation1.75868502
28MP0002088_abnormal_embryonic_growth/wei1.72014411
29MP0009379_abnormal_foot_pigmentation1.69218354
30MP0010307_abnormal_tumor_latency1.67370584
31MP0002084_abnormal_developmental_patter1.67052256
32MP0003646_muscle_fatigue1.64909544
33MP0000490_abnormal_crypts_of1.63335581
34MP0001835_abnormal_antigen_presentation1.59839216
35MP0009840_abnormal_foam_cell1.56484020
36MP0002086_abnormal_extraembryonic_tissu1.55082155
37MP0002429_abnormal_blood_cell1.54411418
38MP0002396_abnormal_hematopoietic_system1.53461615
39MP0010352_gastrointestinal_tract_polyps1.52078411
40MP0003221_abnormal_cardiomyocyte_apopto1.49277219
41MP0000716_abnormal_immune_system1.48522498
42MP0002420_abnormal_adaptive_immunity1.47785746
43MP0001819_abnormal_immune_cell1.45176288
44MP0005000_abnormal_immune_tolerance1.43457898
45MP0000313_abnormal_cell_death1.42709657
46MP0003121_genomic_imprinting1.40639838
47MP0005501_abnormal_skin_physiology1.40364733
48MP0003119_abnormal_digestive_system1.36130143
49MP0003705_abnormal_hypodermis_morpholog1.34121176
50MP0010030_abnormal_orbit_morphology1.32942488
51MP0002019_abnormal_tumor_incidence1.30993844
52MP0003786_premature_aging1.30155452
53MP0000358_abnormal_cell_content/1.29162919
54MP0008004_abnormal_stomach_pH1.28560024
55MP0001800_abnormal_humoral_immune1.28346157
56MP0001849_ear_inflammation1.27512447
57MP0002723_abnormal_immune_serum1.24197652
58MP0004197_abnormal_fetal_growth/weight/1.24165831
59MP0002210_abnormal_sex_determination1.23878804
60MP0002452_abnormal_antigen_presenting1.22744777
61MP0004185_abnormal_adipocyte_glucose1.22367627
62MP0003191_abnormal_cellular_cholesterol1.22064984
63MP0005076_abnormal_cell_differentiation1.22049695
64MP0005451_abnormal_body_composition1.21057327
65MP0009672_abnormal_birth_weight1.18991938
66MP0009333_abnormal_splenocyte_physiolog1.15905470
67MP0003315_abnormal_perineum_morphology1.13573099
68MP0006054_spinal_hemorrhage1.13484042
69MP0005671_abnormal_response_to1.13383159
70MP0003806_abnormal_nucleotide_metabolis1.12894504
71MP0001145_abnormal_male_reproductive1.12514155
72MP0002796_impaired_skin_barrier1.12302837
73MP0000015_abnormal_ear_pigmentation1.12285688
74MP0004808_abnormal_hematopoietic_stem1.12202812
75MP0005025_abnormal_response_to1.11760672
76MP0006292_abnormal_olfactory_placode1.10366567
77MP0000653_abnormal_sex_gland1.08143261
78MP0004381_abnormal_hair_follicle1.06967785
79MP0004947_skin_inflammation1.06686824
80MP0000685_abnormal_immune_system1.03776677
81MP0006036_abnormal_mitochondrial_physio1.03389679
82MP0001929_abnormal_gametogenesis1.03328380
83MP0001119_abnormal_female_reproductive1.02296551
84MP0000537_abnormal_urethra_morphology1.02164019
85MP0010155_abnormal_intestine_physiology1.02127593
86MP0005220_abnormal_exocrine_pancreas1.02098832
87MP0005397_hematopoietic_system_phenotyp1.01393826
88MP0001545_abnormal_hematopoietic_system1.01393826
89MP0000747_muscle_weakness0.99771697
90MP0002419_abnormal_innate_immunity0.99140559
91MP0002132_abnormal_respiratory_system0.97457421
92MP0003866_abnormal_defecation0.96159850
93MP0001853_heart_inflammation0.96083343
94MP0001851_eye_inflammation0.95769642
95MP0004264_abnormal_extraembryonic_tissu0.93859466
96MP0003699_abnormal_female_reproductive0.91471383
97* MP0005384_cellular_phenotype0.89702290
98MP0003724_increased_susceptibility_to0.87726709
99MP0005666_abnormal_adipose_tissue0.87326291
100MP0002009_preneoplasia0.86927825
101MP0002102_abnormal_ear_morphology0.86463801
102MP0003828_pulmonary_edema0.86270656
103* MP0005621_abnormal_cell_physiology0.85071854
104MP0001790_abnormal_immune_system0.85011628
105MP0005387_immune_system_phenotype0.85011628
106MP0002405_respiratory_system_inflammati0.84967897
107MP0002269_muscular_atrophy0.84734811
108MP0002877_abnormal_melanocyte_morpholog0.84127419
109MP0003186_abnormal_redox_activity0.82174961
110MP0000703_abnormal_thymus_morphology0.82003865
111MP0002148_abnormal_hypersensitivity_rea0.78872524
112MP0002127_abnormal_cardiovascular_syste0.78781556
113MP0003566_abnormal_cell_adhesion0.78230905
114MP0001293_anophthalmia0.78168542
115MP0003283_abnormal_digestive_organ0.76080634
116MP0004233_abnormal_muscle_weight0.76056197
117MP0001915_intracranial_hemorrhage0.74101441
118MP0000465_gastrointestinal_hemorrhage0.73566998
119MP0000477_abnormal_intestine_morphology0.72827114
120MP0010630_abnormal_cardiac_muscle0.72715832
121MP0008260_abnormal_autophagy0.72239582
122MP0000759_abnormal_skeletal_muscle0.71136814
123MP0000678_abnormal_parathyroid_gland0.70960750
124MP0000750_abnormal_muscle_regeneration0.70899974
125MP0006035_abnormal_mitochondrial_morpho0.69443351
126MP0001727_abnormal_embryo_implantation0.69417357
127MP0003300_gastrointestinal_ulcer0.68738496
128MP0002722_abnormal_immune_system0.67446762
129MP0001944_abnormal_pancreas_morphology0.67329632
130MP0009278_abnormal_bone_marrow0.67171329
131MP0004084_abnormal_cardiac_muscle0.66586580
132MP0000858_altered_metastatic_potential0.66383231
133MP0004133_heterotaxia0.66331408
134MP0005023_abnormal_wound_healing0.65747246
135MP0003937_abnormal_limbs/digits/tail_de0.64837936
136MP0005187_abnormal_penis_morphology0.64229726
137MP0002160_abnormal_reproductive_system0.64161193
138MP0000266_abnormal_heart_morphology0.62725637
139MP0002398_abnormal_bone_marrow0.62633364
140MP0000689_abnormal_spleen_morphology0.62289354
141MP0005266_abnormal_metabolism0.61268343
142MP0009053_abnormal_anal_canal0.61264588
143MP0002111_abnormal_tail_morphology0.59878408
144MP0000598_abnormal_liver_morphology0.59840658
145MP0000428_abnormal_craniofacial_morphol0.59207909

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.30527617
2Abnormality of cells of the erythroid lineage (HP:0012130)4.12489718
3Microretrognathia (HP:0000308)4.04467196
4Prolonged bleeding time (HP:0003010)4.01531324
5Abnormal number of erythroid precursors (HP:0012131)3.90964174
6Breast hypoplasia (HP:0003187)3.85000291
7Petechiae (HP:0000967)3.83352224
8Colon cancer (HP:0003003)3.68894336
9Oral leukoplakia (HP:0002745)3.63623609
10Multiple enchondromatosis (HP:0005701)3.63601030
11Purpura (HP:0000979)3.46173939
12Reticulocytopenia (HP:0001896)3.44597605
13Progressive external ophthalmoplegia (HP:0000590)3.43600356
14Patellar aplasia (HP:0006443)3.42997715
15Carpal bone hypoplasia (HP:0001498)3.37053195
16Aplasia/Hypoplasia of the patella (HP:0006498)3.22420060
17Centrally nucleated skeletal muscle fibers (HP:0003687)3.17833666
18Abnormal platelet volume (HP:0011876)3.12046116
19Myopathic facies (HP:0002058)3.07577782
20Microvesicular hepatic steatosis (HP:0001414)3.04455713
21Medulloblastoma (HP:0002885)3.04111970
22Exercise-induced myalgia (HP:0003738)2.94780973
23Progressive muscle weakness (HP:0003323)2.92989634
24Abnormality of the anterior horn cell (HP:0006802)2.92526380
25Degeneration of anterior horn cells (HP:0002398)2.92526380
26Selective tooth agenesis (HP:0001592)2.89261881
27Aplastic anemia (HP:0001915)2.89154090
28Ependymoma (HP:0002888)2.84562575
29Increased mean platelet volume (HP:0011877)2.83386739
30Neoplasm of the pancreas (HP:0002894)2.76813438
31Overlapping toe (HP:0001845)2.74378498
32Gastrointestinal inflammation (HP:0004386)2.73596782
33Nemaline bodies (HP:0003798)2.71952402
34Eczematoid dermatitis (HP:0000976)2.68679553
35Cerebral hypomyelination (HP:0006808)2.66739272
36Epistaxis (HP:0000421)2.65816043
37Rough bone trabeculation (HP:0100670)2.63849666
38Facial hemangioma (HP:0000329)2.63330779
39Fatigue (HP:0012378)2.57147176
40Premature ovarian failure (HP:0008209)2.55521473
41Trismus (HP:0000211)2.54849844
42Secondary amenorrhea (HP:0000869)2.51222052
43Muscle fiber inclusion bodies (HP:0100299)2.49470048
44Menorrhagia (HP:0000132)2.47946460
45Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.47374439
46Inflammation of the large intestine (HP:0002037)2.46593018
47Panhypogammaglobulinemia (HP:0003139)2.45570628
48Hypertensive crisis (HP:0100735)2.43540865
49Abnormal gallbladder physiology (HP:0012438)2.43377136
50Cholecystitis (HP:0001082)2.43377136
51Pelvic girdle muscle weakness (HP:0003749)2.42838519
52Slender long bone (HP:0003100)2.42781702
53Abnormality of alanine metabolism (HP:0010916)2.41359383
54Hyperalaninemia (HP:0003348)2.41359383
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41359383
56Increased muscle lipid content (HP:0009058)2.41327834
57Increased serum ferritin (HP:0003281)2.39936020
58Macrocytic anemia (HP:0001972)2.39085913
59Obstructive lung disease (HP:0006536)2.38446257
60Chronic obstructive pulmonary disease (HP:0006510)2.38446257
61Recurrent abscess formation (HP:0002722)2.37307011
62Increased intramyocellular lipid droplets (HP:0012240)2.36446882
63Hepatosplenomegaly (HP:0001433)2.35330553
64Rhabdomyosarcoma (HP:0002859)2.33166386
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.30327893
66Late onset (HP:0003584)2.28235129
67Cellulitis (HP:0100658)2.26993079
68Recurrent viral infections (HP:0004429)2.26377116
69Dysphonia (HP:0001618)2.25603478
70Angiofibromas (HP:0010615)2.24594882
71Adenoma sebaceum (HP:0009720)2.24594882
72Abnormality of skeletal muscle fiber size (HP:0012084)2.24140536
73Distal lower limb muscle weakness (HP:0009053)2.23540558
74Colitis (HP:0002583)2.21606468
75Rhabdomyolysis (HP:0003201)2.20079355
76Myelodysplasia (HP:0002863)2.18974398
77Absent thumb (HP:0009777)2.18658021
78Meckel diverticulum (HP:0002245)2.17050648
79Muscle stiffness (HP:0003552)2.15862579
80Agnosia (HP:0010524)2.15160754
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14139697
82Abnormality of the heme biosynthetic pathway (HP:0010472)2.13773797
83Chromsome breakage (HP:0040012)2.12989260
84Abnormal platelet function (HP:0011869)2.11531223
85Impaired platelet aggregation (HP:0003540)2.11531223
86Basal cell carcinoma (HP:0002671)2.11152884
87External ophthalmoplegia (HP:0000544)2.10362700
88Pallor (HP:0000980)2.09226834
89Abnormality of macrophages (HP:0004311)2.09186743
90Biliary tract neoplasm (HP:0100574)2.09127069
91Abnormality of the preputium (HP:0100587)2.09051595
92Stomatitis (HP:0010280)2.08369522
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.07118103
94Male infertility (HP:0003251)2.06525146
95Global brain atrophy (HP:0002283)2.04862209
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02778384
97Truncus arteriosus (HP:0001660)2.02712560
98CNS hypomyelination (HP:0003429)2.02504180
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01937021
100Abnormality of the ileum (HP:0001549)2.01374419
101Agammaglobulinemia (HP:0004432)2.00940280
102Abnormality of chromosome stability (HP:0003220)2.00244014
103Abnormality of the umbilical cord (HP:0010881)1.99967135
104Seborrheic dermatitis (HP:0001051)1.99107714
105Abnormality of lateral ventricle (HP:0030047)1.96614555
106Ankle contracture (HP:0006466)1.95676024
107Thrombocytosis (HP:0001894)1.95632177
108Abnormality of iron homeostasis (HP:0011031)1.95568729
109Cortical dysplasia (HP:0002539)1.95013900
110Unsteady gait (HP:0002317)1.93680106
111Prominent nose (HP:0000448)1.93170994
112Amaurosis fugax (HP:0100576)1.92868724
113Deep palmar crease (HP:0006191)1.92798664
114Paralysis (HP:0003470)1.92273999
115Bulbar palsy (HP:0001283)1.90850713
116Shawl scrotum (HP:0000049)1.90536146
117Atresia of the external auditory canal (HP:0000413)1.90378144
118Cafe-au-lait spot (HP:0000957)1.89770865
119Broad distal phalanx of finger (HP:0009836)1.89066379
120Testicular atrophy (HP:0000029)1.88259788
121Short middle phalanx of the 5th finger (HP:0004220)1.88182436
122Abnormality of the hip-girdle musculature (HP:0001445)1.86783595
123Abnormality of the musculature of the pelvis (HP:0001469)1.86783595
124Impaired proprioception (HP:0010831)1.86078311
125Neoplasm of the colon (HP:0100273)1.85980823
126Generalized amyotrophy (HP:0003700)1.85448653
127Gastrointestinal dysmotility (HP:0002579)1.85401131
128EMG: myopathic abnormalities (HP:0003458)1.83180524
129Septate vagina (HP:0001153)1.83011122
130Absent radius (HP:0003974)1.82974927
131Abnormal pupillary function (HP:0007686)1.82893604
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82187619
133Small intestinal stenosis (HP:0012848)1.80933426
134Duodenal stenosis (HP:0100867)1.80933426
135IgM deficiency (HP:0002850)1.80904538
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.80823264
137Impulsivity (HP:0100710)1.80088911
138Shoulder girdle muscle weakness (HP:0003547)1.80003534
139Intestinal polyp (HP:0005266)1.79377599
140Distal lower limb amyotrophy (HP:0008944)1.79014398
141Areflexia of lower limbs (HP:0002522)1.78713761
142Easy fatigability (HP:0003388)1.78568705
143Calcaneovalgus deformity (HP:0001848)1.78036491
144Increased connective tissue (HP:0009025)1.77970627
145Tracheoesophageal fistula (HP:0002575)1.77947947
146Abnormal trabecular bone morphology (HP:0100671)1.77402949
147Cellular immunodeficiency (HP:0005374)1.76565039
148Insulin resistance (HP:0000855)1.76311391
149Capillary hemangiomas (HP:0005306)1.75612887
150Postnatal microcephaly (HP:0005484)1.75357458
151Cleft eyelid (HP:0000625)1.74762939
152Increased IgM level (HP:0003496)1.74559294
153Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74125395
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74125395
155Intestinal polyposis (HP:0200008)1.73973371
156Neoplasm of the rectum (HP:0100743)1.73112540
157Abnormal biliary tract morphology (HP:0012440)1.73018720
158Recurrent bacterial skin infections (HP:0005406)1.72627955
159Bicuspid aortic valve (HP:0001647)1.72614374
160Proximal placement of thumb (HP:0009623)1.72337079
161Abnormality of reticulocytes (HP:0004312)1.72076183
162Neoplasm of striated muscle (HP:0009728)1.71581123
163Increased variability in muscle fiber diameter (HP:0003557)1.71457686
164Ragged-red muscle fibers (HP:0003200)1.71412070
165Death in infancy (HP:0001522)1.71033158
166Aplasia/Hypoplasia of the thymus (HP:0010515)1.70037514
167Mediastinal lymphadenopathy (HP:0100721)1.70006324
168Bone marrow hypocellularity (HP:0005528)1.69882189
169Abnormality of the duodenum (HP:0002246)1.68855282
170Personality changes (HP:0000751)1.67717356
171Abnormal umbilical cord blood vessels (HP:0011403)1.66709817
172Single umbilical artery (HP:0001195)1.66709817
173Abnormality of the fetal cardiovascular system (HP:0010948)1.66709817
174Reduced antithrombin III activity (HP:0001976)1.65863229
175Horseshoe kidney (HP:0000085)1.65395278
176Abnormality of the calcaneus (HP:0008364)1.65311558
177Gingival bleeding (HP:0000225)1.65092836
178Deformed tarsal bones (HP:0008119)1.65005007
179Myoglobinuria (HP:0002913)1.63233605
180Growth hormone excess (HP:0000845)1.63212192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.42930139
2NEK23.44923402
3WEE13.35735635
4EEF2K3.28805564
5SMG13.25600639
6CDC73.22575202
7PRPF4B3.02049471
8ACVR1B2.55100735
9NEK12.44360014
10DYRK32.42328502
11TRIB32.34447744
12TTK2.23242576
13EIF2AK12.19692767
14NME22.06802889
15PKN22.04401091
16LATS22.00404958
17STK161.94529205
18BRSK21.94009109
19RPS6KA41.91535337
20MAPKAPK31.89068959
21MAP3K101.84958876
22PLK11.81786122
23RPS6KB21.78495277
24PLK41.71613223
25TAOK21.70363068
26SCYL21.67469855
27PBK1.65179500
28BRAF1.57996304
29KSR21.55629770
30AURKB1.55585580
31VRK21.55132129
32CDK71.48573210
33RIPK41.45262139
34AURKA1.42592262
35TESK21.42300505
36CDK41.42213501
37ZAK1.41953532
38MAP3K81.41407024
39RAF11.38949559
40TAOK11.38867229
41MAP3K131.37631747
42BCKDK1.35606235
43BRSK11.35433372
44IRAK31.33781288
45PIM21.32402980
46PASK1.27673140
47CHEK21.25289304
48FES1.21327667
49BMX1.19394529
50TTN1.16650992
51EIF2AK31.16295504
52BTK1.14317704
53PAK41.13099476
54STK101.10052409
55MAP3K11.09815803
56CDK81.07082257
57DYRK21.06011167
58KSR11.05755347
59CDK121.03914599
60MAP2K31.03456726
61MAP3K111.02981047
62TLK11.02707578
63SRPK11.01728520
64TBK10.98170251
65VRK10.97769094
66ATR0.97080077
67FLT30.92820899
68IRAK40.89830375
69ARAF0.88966202
70STK38L0.88229132
71LATS10.86228157
72CDK190.85630697
73PAK10.84137431
74MAP3K60.83730658
75SIK10.82464680
76NME10.81891056
77KDR0.80985108
78CHEK10.80649645
79MAP3K90.80374497
80CSF1R0.79451482
81IRAK20.78486518
82PLK30.76005840
83JAK30.74703376
84PRKCI0.73785302
85STK30.72307540
86ICK0.70366207
87TYK20.69262859
88ERN10.68010172
89MELK0.65163985
90IKBKB0.63359976
91CDK20.62267531
92ILK0.61112628
93EPHA20.60924015
94LRRK20.59796322
95TGFBR10.58840180
96MAPK110.58647662
97TESK10.58004921
98HCK0.57226553
99ABL20.54701815
100MAP3K140.53986387
101CSK0.53106600
102MAPK120.52234888
103STK40.52013311
104MTOR0.50701431
105FGFR40.49587693
106DAPK10.49346800
107TSSK60.48144089
108ZAP700.46924780
109PRKD20.46482067
110PIM10.46136946
111ERBB40.45012158
112AKT20.44202657
113ATM0.43825940
114MAPKAPK20.43809176
115RPS6KL10.42437039
116RPS6KC10.42437039
117MAP4K10.42323796
118GRK60.41901064
119MOS0.41595321
120MAP3K50.40477971
121SYK0.38324577
122FGR0.37640562
123CDK90.37292710
124DAPK30.37020587
125MAP2K20.36962607
126CDK10.36911948
127TNK20.36471486
128HIPK20.34948715
129RPS6KA50.32619558
130ALK0.31529989
131CSNK2A10.31251461
132CSNK2A20.30213442
133RPS6KA10.29445175
134MAP3K30.28140018
135CDK60.28003050
136CCNB10.25111123
137TYRO30.23517007
138DYRK1B0.23046418
139MKNK10.22920852
140MARK30.22419361

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49523347
2RNA polymerase_Homo sapiens_hsa030203.66766749
3Mismatch repair_Homo sapiens_hsa034303.45917453
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31690018
5Ribosome_Homo sapiens_hsa030103.27549642
6Cell cycle_Homo sapiens_hsa041103.27024129
7RNA transport_Homo sapiens_hsa030133.25097039
8Spliceosome_Homo sapiens_hsa030403.16207938
9Base excision repair_Homo sapiens_hsa034102.82452194
10Pyrimidine metabolism_Homo sapiens_hsa002402.56576136
11Proteasome_Homo sapiens_hsa030502.37824133
12Nucleotide excision repair_Homo sapiens_hsa034202.37033193
13Homologous recombination_Homo sapiens_hsa034402.26942385
14RNA degradation_Homo sapiens_hsa030182.03134955
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00648924
16One carbon pool by folate_Homo sapiens_hsa006702.00190902
17Basal transcription factors_Homo sapiens_hsa030221.94320568
18Primary immunodeficiency_Homo sapiens_hsa053401.92337722
19Folate biosynthesis_Homo sapiens_hsa007901.74066414
20Vitamin B6 metabolism_Homo sapiens_hsa007501.72484759
21Sulfur relay system_Homo sapiens_hsa041221.70564820
22mRNA surveillance pathway_Homo sapiens_hsa030151.68146675
23Fanconi anemia pathway_Homo sapiens_hsa034601.60866594
24p53 signaling pathway_Homo sapiens_hsa041151.60483087
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49736925
26B cell receptor signaling pathway_Homo sapiens_hsa046621.44755812
27Pentose phosphate pathway_Homo sapiens_hsa000301.43101949
28Oocyte meiosis_Homo sapiens_hsa041141.41988151
29Biosynthesis of amino acids_Homo sapiens_hsa012301.39028743
30Purine metabolism_Homo sapiens_hsa002301.37841938
31Thyroid cancer_Homo sapiens_hsa052161.27043870
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23071570
33Fatty acid elongation_Homo sapiens_hsa000621.16680102
34Platelet activation_Homo sapiens_hsa046111.14894713
35Systemic lupus erythematosus_Homo sapiens_hsa053221.11632413
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.09866087
37Selenocompound metabolism_Homo sapiens_hsa004501.07652729
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04583671
39Epstein-Barr virus infection_Homo sapiens_hsa051691.03699629
40Non-homologous end-joining_Homo sapiens_hsa034501.03424504
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99362365
42T cell receptor signaling pathway_Homo sapiens_hsa046600.98626823
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.98232045
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97798703
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.97227379
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96680515
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96284474
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94630027
49Carbon metabolism_Homo sapiens_hsa012000.93147078
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92155427
51Osteoclast differentiation_Homo sapiens_hsa043800.90030062
52Bladder cancer_Homo sapiens_hsa052190.89882886
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82966037
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81460940
55Viral carcinogenesis_Homo sapiens_hsa052030.78826762
56Measles_Homo sapiens_hsa051620.78282010
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.77625299
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76646994
59N-Glycan biosynthesis_Homo sapiens_hsa005100.75780721
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75515331
61Colorectal cancer_Homo sapiens_hsa052100.75093220
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74179707
63Renal cell carcinoma_Homo sapiens_hsa052110.73675451
64Viral myocarditis_Homo sapiens_hsa054160.72040784
65mTOR signaling pathway_Homo sapiens_hsa041500.71027845
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70913767
67Protein export_Homo sapiens_hsa030600.69301517
68HTLV-I infection_Homo sapiens_hsa051660.66117772
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.65432925
70Chronic myeloid leukemia_Homo sapiens_hsa052200.64833283
71Herpes simplex infection_Homo sapiens_hsa051680.64214202
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61307790
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61034449
74MicroRNAs in cancer_Homo sapiens_hsa052060.60902532
75Leishmaniasis_Homo sapiens_hsa051400.60538708
76Hematopoietic cell lineage_Homo sapiens_hsa046400.59776439
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59375069
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58927789
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.58264795
80Hippo signaling pathway_Homo sapiens_hsa043900.58203020
81Alcoholism_Homo sapiens_hsa050340.56954319
82Small cell lung cancer_Homo sapiens_hsa052220.56808186
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56517995
84Endocytosis_Homo sapiens_hsa041440.54580361
85Endometrial cancer_Homo sapiens_hsa052130.53367541
86TGF-beta signaling pathway_Homo sapiens_hsa043500.53334313
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.51640014
88Circadian rhythm_Homo sapiens_hsa047100.47456742
89Non-small cell lung cancer_Homo sapiens_hsa052230.46802670
90Regulation of autophagy_Homo sapiens_hsa041400.46293030
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46162694
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.45624073
93Shigellosis_Homo sapiens_hsa051310.44940902
94Glioma_Homo sapiens_hsa052140.44642095
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44540255
96Antigen processing and presentation_Homo sapiens_hsa046120.44346199
97Prostate cancer_Homo sapiens_hsa052150.44322578
98Legionellosis_Homo sapiens_hsa051340.41930744
99Pancreatic cancer_Homo sapiens_hsa052120.41379930
100Acute myeloid leukemia_Homo sapiens_hsa052210.40940043
101Parkinsons disease_Homo sapiens_hsa050120.40490465
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39845581
103Notch signaling pathway_Homo sapiens_hsa043300.39625460
104Galactose metabolism_Homo sapiens_hsa000520.38294318
105Chemokine signaling pathway_Homo sapiens_hsa040620.38006173
106Huntingtons disease_Homo sapiens_hsa050160.36752163
107Apoptosis_Homo sapiens_hsa042100.34834817
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34492793
109Fructose and mannose metabolism_Homo sapiens_hsa000510.33130639
110VEGF signaling pathway_Homo sapiens_hsa043700.31949803
111Linoleic acid metabolism_Homo sapiens_hsa005910.31481003
112AMPK signaling pathway_Homo sapiens_hsa041520.30674609
113Basal cell carcinoma_Homo sapiens_hsa052170.29916239
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29743803
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29469085
116Hepatitis B_Homo sapiens_hsa051610.28560634
117Insulin signaling pathway_Homo sapiens_hsa049100.28451782
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26571950
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25799957
120Glutathione metabolism_Homo sapiens_hsa004800.24633513
121FoxO signaling pathway_Homo sapiens_hsa040680.24614975
122Metabolic pathways_Homo sapiens_hsa011000.23159378
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22433029
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21842672
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21426031
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.20496862
127Arginine and proline metabolism_Homo sapiens_hsa003300.18841661
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.18121581
129Prolactin signaling pathway_Homo sapiens_hsa049170.17989913
130HIF-1 signaling pathway_Homo sapiens_hsa040660.17492261
131Pathways in cancer_Homo sapiens_hsa052000.17425155

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