THAP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.00008444
2nuclear pore organization (GO:0006999)6.00513833
3mitotic sister chromatid cohesion (GO:0007064)5.99116231
4mitotic chromosome condensation (GO:0007076)5.16420948
5pore complex assembly (GO:0046931)5.04164732
6DNA synthesis involved in DNA repair (GO:0000731)4.47907145
7negative regulation of DNA repair (GO:0045738)4.43925385
8regulation of RNA export from nucleus (GO:0046831)4.38901563
9synapsis (GO:0007129)4.27945455
10regulation of centriole replication (GO:0046599)4.06945549
11ribosome assembly (GO:0042255)4.06088005
12DNA unwinding involved in DNA replication (GO:0006268)4.03669095
13DNA topological change (GO:0006265)4.02278535
14monoubiquitinated protein deubiquitination (GO:0035520)3.97506583
15positive regulation of natural killer cell differentiation (GO:0032825)3.92232283
16sister chromatid cohesion (GO:0007062)3.91827362
17sister chromatid segregation (GO:0000819)3.81518213
18meiotic chromosome segregation (GO:0045132)3.78409421
19regulation of histone H3-K9 methylation (GO:0051570)3.72695519
20nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.59451305
21definitive hemopoiesis (GO:0060216)3.55524840
22regulation of nucleobase-containing compound transport (GO:0032239)3.51152878
23mitotic sister chromatid segregation (GO:0000070)3.40124652
24DNA duplex unwinding (GO:0032508)3.38139819
25protein localization to chromosome, centromeric region (GO:0071459)3.35653738
26chromosome organization involved in meiosis (GO:0070192)3.35199835
27positive regulation of mitotic sister chromatid separation (GO:1901970)3.28852258
28positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28852258
29positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28852258
30DNA geometric change (GO:0032392)3.28604588
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24600942
32formation of translation preinitiation complex (GO:0001731)3.24098652
33mitotic metaphase plate congression (GO:0007080)3.21474446
34regulation of sister chromatid cohesion (GO:0007063)3.18569121
35histone H3-K36 demethylation (GO:0070544)3.14089515
36dosage compensation (GO:0007549)3.11517931
37regulation of DNA endoreduplication (GO:0032875)3.10106588
38DNA conformation change (GO:0071103)3.09975693
39mitotic nuclear envelope disassembly (GO:0007077)3.09409489
40negative regulation of erythrocyte differentiation (GO:0045647)3.06135882
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05554042
42positive regulation of chromosome segregation (GO:0051984)3.04954631
43RNA stabilization (GO:0043489)3.04945580
44mRNA stabilization (GO:0048255)3.04945580
45protein localization to kinetochore (GO:0034501)3.01520382
46regulation of DNA damage checkpoint (GO:2000001)2.98184393
47viral mRNA export from host cell nucleus (GO:0046784)2.97202043
48metaphase plate congression (GO:0051310)2.95411295
49nuclear envelope disassembly (GO:0051081)2.94667708
50membrane disassembly (GO:0030397)2.94667708
51regulation of histone H3-K27 methylation (GO:0061085)2.91266143
52kinetochore organization (GO:0051383)2.84158188
53negative regulation of histone methylation (GO:0031061)2.84057542
54regulation of centrosome duplication (GO:0010824)2.82787746
55regulation of centrosome cycle (GO:0046605)2.81899965
56chromosome condensation (GO:0030261)2.81772009
57DNA packaging (GO:0006323)2.80721690
58positive regulation of interleukin-17 production (GO:0032740)2.79650227
59V(D)J recombination (GO:0033151)2.77681674
60regulation of double-strand break repair (GO:2000779)2.77510361
61positive regulation of histone methylation (GO:0031062)2.77420258
62DNA replication initiation (GO:0006270)2.76002068
63gene silencing by RNA (GO:0031047)2.74737067
64protein localization to chromosome (GO:0034502)2.73471645
65establishment of chromosome localization (GO:0051303)2.72777342
66phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.71649480
67positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.71453238
68positive regulation of gamma-delta T cell activation (GO:0046645)2.71183108
69histone H3-K9 demethylation (GO:0033169)2.70020043
70hepatocyte apoptotic process (GO:0097284)2.69191542
71telomere maintenance via recombination (GO:0000722)2.68361614
72nucleus organization (GO:0006997)2.66440367
73chromosome segregation (GO:0007059)2.65994316
74histone H4-K16 acetylation (GO:0043984)2.64732519
75regulation of histone methylation (GO:0031060)2.63616866
76mitotic recombination (GO:0006312)2.63241519
77positive regulation of B cell differentiation (GO:0045579)2.61385892
783-UTR-mediated mRNA stabilization (GO:0070935)2.61313875
79mRNA transport (GO:0051028)2.59345567
80cytoplasmic mRNA processing body assembly (GO:0033962)2.57431415
81histone phosphorylation (GO:0016572)2.56257894
82regulation of chromosome segregation (GO:0051983)2.56156159
83interkinetic nuclear migration (GO:0022027)2.55293130
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.55257099
85regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55257099
86mRNA export from nucleus (GO:0006406)2.55015022
87RNA export from nucleus (GO:0006405)2.54532468
88regulation of mitotic sister chromatid separation (GO:0010965)2.53425300
89regulation of mitotic sister chromatid segregation (GO:0033047)2.53425300
90regulation of sister chromatid segregation (GO:0033045)2.53425300
91poly(A)+ mRNA export from nucleus (GO:0016973)2.53167127
92histone H2B ubiquitination (GO:0033523)2.52902747
93necroptotic process (GO:0070266)2.52324803
94non-recombinational repair (GO:0000726)2.51998495
95double-strand break repair via nonhomologous end joining (GO:0006303)2.51998495
96histone-serine phosphorylation (GO:0035404)2.51871650
97positive regulation of protein import into nucleus, translocation (GO:0033160)2.50638504
98DNA strand elongation involved in DNA replication (GO:0006271)2.47763613
99regulation of natural killer cell differentiation (GO:0032823)2.47188132
100positive regulation of granulocyte differentiation (GO:0030854)2.46469821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55981457
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.98000539
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81471144
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.56058868
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.35117383
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33419447
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.16844857
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97391477
9MYC_22102868_ChIP-Seq_BL_Human2.87062443
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79996977
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.60138668
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.58698620
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57112432
14AR_21909140_ChIP-Seq_LNCAP_Human2.30905814
15ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.21918039
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12835595
17GATA1_22025678_ChIP-Seq_K562_Human2.07662055
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03054185
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99608803
20MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88190160
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88128350
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83521083
23ELK1_19687146_ChIP-ChIP_HELA_Human1.83238777
24ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80758468
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78395115
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75033195
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.73489425
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71498193
29CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.70926822
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65293681
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61343007
32SCL_19346495_ChIP-Seq_HPC-7_Human1.61247288
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61201930
34MYB_26560356_Chip-Seq_TH2_Human1.56393691
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55723067
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55463068
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48921298
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.46710881
39MYB_26560356_Chip-Seq_TH1_Human1.44987760
40TFEB_21752829_ChIP-Seq_HELA_Human1.44565482
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44507619
42KDM5A_27292631_Chip-Seq_BREAST_Human1.41770693
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41647368
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38810417
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35250735
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31426016
47DCP1A_22483619_ChIP-Seq_HELA_Human1.30291098
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29439424
49SPI1_23547873_ChIP-Seq_NB4_Human1.27922868
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26712625
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26090847
52CHD1_26751641_Chip-Seq_LNCaP_Human1.25603619
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24420728
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23559766
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21815418
56FOXP3_21729870_ChIP-Seq_TREG_Human1.20226149
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19456081
58VDR_23849224_ChIP-Seq_CD4+_Human1.18948084
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18539575
60FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16344738
61TCF7_22412390_ChIP-Seq_EML_Mouse1.16215086
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13968447
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11204227
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09993059
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09060603
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08667882
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08445523
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06956105
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05346600
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05043441
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04547280
72CIITA_25753668_ChIP-Seq_RAJI_Human1.04339496
73TTF2_22483619_ChIP-Seq_HELA_Human1.02857714
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02729131
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98591686
76MAF_26560356_Chip-Seq_TH1_Human0.98270581
77FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98127386
78KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97682151
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97186903
80RUNX_20019798_ChIP-Seq_JUKART_Human0.97153698
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96536796
82WT1_19549856_ChIP-ChIP_CCG9911_Human0.96192305
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95689277
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95612116
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95612116
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93645126
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92814009
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92058992
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88956822
90GABP_17652178_ChIP-ChIP_JURKAT_Human0.87722754
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87407208
92GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87292329
93RUNX1_22412390_ChIP-Seq_EML_Mouse0.87053634
94VDR_21846776_ChIP-Seq_THP-1_Human0.86704254
95NCOR1_26117541_ChIP-Seq_K562_Human0.86356493
96EWS_26573619_Chip-Seq_HEK293_Human0.86315625
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85506528
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84576694
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84065474
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83733923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.75178124
2MP0002009_preneoplasia3.44262373
3MP0002396_abnormal_hematopoietic_system3.02974540
4MP0010352_gastrointestinal_tract_polyps2.93840202
5MP0010094_abnormal_chromosome_stability2.86440103
6MP0004957_abnormal_blastocyst_morpholog2.85869293
7MP0004808_abnormal_hematopoietic_stem2.71163808
8MP0003693_abnormal_embryo_hatching2.70303418
9MP0002877_abnormal_melanocyte_morpholog2.68096661
10MP0003763_abnormal_thymus_physiology2.52450217
11MP0003077_abnormal_cell_cycle2.49857688
12MP0003111_abnormal_nucleus_morphology2.47291610
13MP0005076_abnormal_cell_differentiation2.38868227
14MP0008058_abnormal_DNA_repair2.24148487
15MP0010234_abnormal_vibrissa_follicle2.18422709
16MP0004185_abnormal_adipocyte_glucose2.08653709
17MP0010307_abnormal_tumor_latency2.08395175
18MP0001873_stomach_inflammation1.99813764
19MP0000569_abnormal_digit_pigmentation1.89946827
20MP0001730_embryonic_growth_arrest1.81909647
21MP0010678_abnormal_skin_adnexa1.81901988
22MP0005451_abnormal_body_composition1.80872419
23MP0000350_abnormal_cell_proliferation1.65445403
24MP0000383_abnormal_hair_follicle1.65070540
25MP0002166_altered_tumor_susceptibility1.64252067
26MP0001672_abnormal_embryogenesis/_devel1.61700183
27MP0005380_embryogenesis_phenotype1.61700183
28MP0003984_embryonic_growth_retardation1.59460295
29MP0003943_abnormal_hepatobiliary_system1.58681335
30MP0008007_abnormal_cellular_replicative1.57792851
31MP0009697_abnormal_copulation1.57463896
32MP0002088_abnormal_embryonic_growth/wei1.56684331
33MP0002086_abnormal_extraembryonic_tissu1.47162064
34MP0003221_abnormal_cardiomyocyte_apopto1.43045518
35MP0001697_abnormal_embryo_size1.42728720
36MP0000703_abnormal_thymus_morphology1.41982357
37MP0008877_abnormal_DNA_methylation1.41599221
38MP0002398_abnormal_bone_marrow1.29945414
39MP0002006_tumorigenesis1.28621318
40MP0002080_prenatal_lethality1.25885597
41MP0002084_abnormal_developmental_patter1.25508949
42MP0003890_abnormal_embryonic-extraembry1.24701910
43MP0000490_abnormal_crypts_of1.24431223
44MP0001835_abnormal_antigen_presentation1.22411036
45MP0008932_abnormal_embryonic_tissue1.15307044
46MP0003300_gastrointestinal_ulcer1.15146634
47MP0009333_abnormal_splenocyte_physiolog1.13561576
48MP0005310_abnormal_salivary_gland1.12103003
49MP0001348_abnormal_lacrimal_gland1.11922090
50MP0004197_abnormal_fetal_growth/weight/1.10912288
51MP0000313_abnormal_cell_death1.09343475
52MP0003567_abnormal_fetal_cardiomyocyte1.09121118
53MP0002019_abnormal_tumor_incidence1.08543727
54MP0004264_abnormal_extraembryonic_tissu1.07772773
55MP0000689_abnormal_spleen_morphology1.04755573
56MP0002722_abnormal_immune_system1.02081960
57MP0002085_abnormal_embryonic_tissue1.02036722
58MP0000377_abnormal_hair_follicle0.98926766
59MP0000427_abnormal_hair_cycle0.93391907
60MP0002210_abnormal_sex_determination0.92948651
61MP0009703_decreased_birth_body0.92749306
62MP0001545_abnormal_hematopoietic_system0.90558781
63MP0005397_hematopoietic_system_phenotyp0.90558781
64MP0000465_gastrointestinal_hemorrhage0.89763875
65MP0000537_abnormal_urethra_morphology0.89636981
66MP0001929_abnormal_gametogenesis0.89108295
67MP0003705_abnormal_hypodermis_morpholog0.88357846
68MP0005621_abnormal_cell_physiology0.86781026
69MP0009672_abnormal_birth_weight0.85985429
70MP0003123_paternal_imprinting0.84374833
71MP0000428_abnormal_craniofacial_morphol0.82338739
72MP0005501_abnormal_skin_physiology0.82131445
73MP0003656_abnormal_erythrocyte_physiolo0.81601974
74MP0005666_abnormal_adipose_tissue0.80297822
75MP0003646_muscle_fatigue0.80253121
76MP0001216_abnormal_epidermal_layer0.79972993
77MP0002429_abnormal_blood_cell0.79822760
78MP0000627_abnormal_mammary_gland0.77672131
79MP0001851_eye_inflammation0.77658736
80MP0000716_abnormal_immune_system0.77610938
81MP0002796_impaired_skin_barrier0.75948960
82MP0001145_abnormal_male_reproductive0.75887643
83MP0005384_cellular_phenotype0.74791724
84MP0005464_abnormal_platelet_physiology0.73522438
85MP0002420_abnormal_adaptive_immunity0.72760255
86MP0002405_respiratory_system_inflammati0.72754563
87MP0003828_pulmonary_edema0.71813428
88MP0000015_abnormal_ear_pigmentation0.70165935
89MP0002970_abnormal_white_adipose0.69690545
90MP0001800_abnormal_humoral_immune0.69412852
91MP0003699_abnormal_female_reproductive0.68982436
92MP0003453_abnormal_keratinocyte_physiol0.68628313
93MP0003786_premature_aging0.68306954
94MP0001819_abnormal_immune_cell0.67836280
95MP0000358_abnormal_cell_content/0.67777291
96MP0000653_abnormal_sex_gland0.66179585
97MP0002098_abnormal_vibrissa_morphology0.66178075
98MP0003091_abnormal_cell_migration0.65389748
99MP0001119_abnormal_female_reproductive0.64689021
100MP0004233_abnormal_muscle_weight0.64508202

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.38556107
2Chromsome breakage (HP:0040012)4.14950348
3Acute myeloid leukemia (HP:0004808)3.92840807
4Curly hair (HP:0002212)3.66570147
5Volvulus (HP:0002580)3.65061225
6Papillary thyroid carcinoma (HP:0002895)3.45332679
7Asymmetry of the thorax (HP:0001555)3.38770488
8Nephroblastoma (Wilms tumor) (HP:0002667)3.38600306
9Spinal cord lesions (HP:0100561)3.38318406
10Syringomyelia (HP:0003396)3.38318406
11Deep philtrum (HP:0002002)3.32327116
12Chronic diarrhea (HP:0002028)3.23384442
13Embryonal renal neoplasm (HP:0011794)3.18010871
14Missing ribs (HP:0000921)3.02142002
15Myelodysplasia (HP:0002863)2.99091722
16Thyroid carcinoma (HP:0002890)2.90644575
17Gastrointestinal inflammation (HP:0004386)2.88218440
18Termporal pattern (HP:0011008)2.85055839
19Insidious onset (HP:0003587)2.85055839
2011 pairs of ribs (HP:0000878)2.82503989
21Cystic hygroma (HP:0000476)2.81944880
22Inflammation of the large intestine (HP:0002037)2.81353026
23Fatigue (HP:0012378)2.75719499
24Acute lymphatic leukemia (HP:0006721)2.74152376
25Cafe-au-lait spot (HP:0000957)2.66356344
26Subacute progressive viral hepatitis (HP:0006572)2.65985715
27Overlapping toe (HP:0001845)2.65285136
28Abnormality of chromosome stability (HP:0003220)2.63393787
29Subaortic stenosis (HP:0001682)2.57840892
30Abnormality of the left ventricular outflow tract (HP:0011103)2.57840892
31Viral hepatitis (HP:0006562)2.55269896
32Increased nuchal translucency (HP:0010880)2.51647797
33Autoimmune hemolytic anemia (HP:0001890)2.45164033
34Transitional cell carcinoma of the bladder (HP:0006740)2.42597574
35Capillary hemangiomas (HP:0005306)2.40769720
36T lymphocytopenia (HP:0005403)2.36709695
37Progressive external ophthalmoplegia (HP:0000590)2.36473924
38Ankyloglossia (HP:0010296)2.35937761
39Deviation of the thumb (HP:0009603)2.33689615
40Sandal gap (HP:0001852)2.31491622
41Leiomyosarcoma (HP:0100243)2.30994195
42Uterine leiomyosarcoma (HP:0002891)2.30994195
43Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.28153400
44Bladder carcinoma (HP:0002862)2.27646395
45Bladder neoplasm (HP:0009725)2.27646395
46Truncal obesity (HP:0001956)2.26025103
47Abnormality of the preputium (HP:0100587)2.24240036
48B lymphocytopenia (HP:0010976)2.23050451
49Malignant gastrointestinal tract tumors (HP:0006749)2.22385342
50Gastrointestinal carcinoma (HP:0002672)2.22385342
51Dysmetric saccades (HP:0000641)2.19535969
52Prominent nose (HP:0000448)2.19230791
53Coarse hair (HP:0002208)2.17443491
54Heterotopia (HP:0002282)2.16146850
55Relative macrocephaly (HP:0004482)2.15822994
56Rhabdomyosarcoma (HP:0002859)2.15401291
57Facial hemangioma (HP:0000329)2.13538969
58Micronodular cirrhosis (HP:0001413)2.08007371
59Abnormality of T cell number (HP:0011839)2.07198016
60Skull defect (HP:0001362)2.06789070
61Absent frontal sinuses (HP:0002688)2.03270562
62Low anterior hairline (HP:0000294)2.02516206
63Cubitus valgus (HP:0002967)1.97063435
64Macroorchidism (HP:0000053)1.96735701
65Recurrent viral infections (HP:0004429)1.95700639
66Medulloblastoma (HP:0002885)1.94611045
67Abnormality of chromosome segregation (HP:0002916)1.92991460
68Abnormality of B cell number (HP:0010975)1.92865444
69Radioulnar synostosis (HP:0002974)1.90686829
70Embryonal neoplasm (HP:0002898)1.89144354
71Abnormality of the distal phalanx of the thumb (HP:0009617)1.89098736
72High anterior hairline (HP:0009890)1.88130513
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86511200
74Birth length less than 3rd percentile (HP:0003561)1.86376525
75Microglossia (HP:0000171)1.85459887
76Abnormality of the fingertips (HP:0001211)1.84697380
77Diastasis recti (HP:0001540)1.83607262
78Neonatal hypoglycemia (HP:0001998)1.83240910
79Ectopic kidney (HP:0000086)1.82343389
80Lower limb hyperreflexia (HP:0002395)1.79819232
81Central scotoma (HP:0000603)1.79659519
82Dislocated radial head (HP:0003083)1.77593619
83Abnormality of oral frenula (HP:0000190)1.76446674
84Neoplasm of the adrenal cortex (HP:0100641)1.75876058
85Uterine neoplasm (HP:0010784)1.75057798
86Biliary tract neoplasm (HP:0100574)1.74909720
87Breast carcinoma (HP:0003002)1.73808197
88Lymphedema (HP:0001004)1.72288009
89Duodenal stenosis (HP:0100867)1.71841891
90Small intestinal stenosis (HP:0012848)1.71841891
91Proximal placement of thumb (HP:0009623)1.70383730
92Neoplasm of the small intestine (HP:0100833)1.69902314
93Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.69285027
94Somatic mutation (HP:0001428)1.68841145
95Exostoses (HP:0100777)1.68576853
96Low posterior hairline (HP:0002162)1.67999760
97Abnormality of the radial head (HP:0003995)1.67905799
98Cutaneous melanoma (HP:0012056)1.65327780
99Enlarged penis (HP:0000040)1.64776387
100Thrombocytosis (HP:0001894)1.64736686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL23.94187346
2EIF2AK33.68920706
3MAP3K103.11527543
4BRD43.09206214
5LATS13.06540219
6EIF2AK12.95533576
7KSR22.12172657
8CDK62.08612006
9KSR12.03487383
10CDK121.94762248
11PNCK1.92492549
12TAF11.91770085
13SRPK11.87234217
14TTK1.80166873
15NEK11.78689873
16PBK1.74149002
17INSRR1.67406488
18PASK1.67177035
19BRSK21.64163779
20RPS6KB21.60410992
21TRIB31.59413791
22STK31.53764775
23RPS6KA41.51039647
24CDC71.50280770
25CLK11.46895247
26RAF11.46785006
27MKNK21.45396124
28EEF2K1.44675570
29PRPF4B1.43073357
30CDK41.40380737
31BMPR21.38498027
32WEE11.38450061
33MAP3K141.36407238
34ERBB31.32806930
35NEK21.22303481
36MKNK11.21943624
37EIF2AK21.20590764
38TSSK61.20013006
39CCNB11.14722386
40MAP3K21.14400263
41YES11.11324864
42IRAK31.09066811
43STK38L1.00214626
44PLK40.99483300
45NEK90.95783797
46CHEK20.93754867
47SMG10.92547280
48STK240.91630253
49ATR0.91053365
50MET0.90685628
51CSF1R0.89824206
52CHEK10.86682417
53RPS6KB10.83680848
54MELK0.83364689
55FGFR30.81982307
56BTK0.80809387
57PDGFRA0.79284575
58CDK70.78963399
59PKN20.78227371
60ATM0.76679174
61PLK10.74785793
62JAK30.73688183
63CAMK1G0.68692248
64PDGFRB0.63922888
65MAP2K30.63309645
66MST1R0.62308519
67RET0.62188046
68MST40.61616797
69MAP3K80.60963354
70BUB10.60663792
71LATS20.60007437
72MTOR0.58889974
73TTN0.58692122
74AURKB0.57874061
75NEK60.56694783
76MAP3K120.56507585
77TEC0.54405668
78SIK30.54279893
79MAP2K10.53020992
80CDK10.51848125
81ITK0.51341228
82CDK190.51244376
83CDK20.49983028
84MAP3K130.49654933
85JAK20.44960796
86SGK30.44761409
87JAK10.42991696
88ALK0.42725369
89HCK0.40081157
90MAP3K10.39990918
91PTK60.39498298
92TRPM70.38579084
93IRAK20.37873297
94ZAP700.37093164
95MAPK100.35042632
96ACVR1B0.32927003
97NLK0.32618192
98PLK30.31929668
99STK100.30249909
100PAK20.30139775

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.67574639
2Cell cycle_Homo sapiens_hsa041102.59756213
3DNA replication_Homo sapiens_hsa030302.34427967
4Chronic myeloid leukemia_Homo sapiens_hsa052202.31994917
5RNA transport_Homo sapiens_hsa030132.28901820
6Non-small cell lung cancer_Homo sapiens_hsa052232.15954374
7mRNA surveillance pathway_Homo sapiens_hsa030152.15829780
8Pancreatic cancer_Homo sapiens_hsa052121.89890701
9B cell receptor signaling pathway_Homo sapiens_hsa046621.85574168
10Acute myeloid leukemia_Homo sapiens_hsa052211.82977177
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73521414
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73262640
13T cell receptor signaling pathway_Homo sapiens_hsa046601.72337648
14Thyroid cancer_Homo sapiens_hsa052161.71560370
15Spliceosome_Homo sapiens_hsa030401.64389976
16Colorectal cancer_Homo sapiens_hsa052101.64021559
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61134067
18Endometrial cancer_Homo sapiens_hsa052131.58839437
19Mismatch repair_Homo sapiens_hsa034301.56913146
20Renal cell carcinoma_Homo sapiens_hsa052111.55845783
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53376153
22Hepatitis B_Homo sapiens_hsa051611.46859278
23Prostate cancer_Homo sapiens_hsa052151.43282267
24Small cell lung cancer_Homo sapiens_hsa052221.41555704
25mTOR signaling pathway_Homo sapiens_hsa041501.41334590
26Viral carcinogenesis_Homo sapiens_hsa052031.39251991
27Prolactin signaling pathway_Homo sapiens_hsa049171.37795070
28MicroRNAs in cancer_Homo sapiens_hsa052061.34874874
29Measles_Homo sapiens_hsa051621.31030863
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.28506605
31ErbB signaling pathway_Homo sapiens_hsa040121.27995913
32Nucleotide excision repair_Homo sapiens_hsa034201.27681725
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26042788
34VEGF signaling pathway_Homo sapiens_hsa043701.23479648
35Fanconi anemia pathway_Homo sapiens_hsa034601.22437171
36FoxO signaling pathway_Homo sapiens_hsa040681.21473338
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18578782
38Base excision repair_Homo sapiens_hsa034101.18252444
39p53 signaling pathway_Homo sapiens_hsa041151.18002975
40Herpes simplex infection_Homo sapiens_hsa051681.16936230
41Inositol phosphate metabolism_Homo sapiens_hsa005621.14829023
42HTLV-I infection_Homo sapiens_hsa051661.11932032
43Glioma_Homo sapiens_hsa052141.08773767
44Basal transcription factors_Homo sapiens_hsa030221.08499947
45Bladder cancer_Homo sapiens_hsa052191.07971584
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06259311
47Homologous recombination_Homo sapiens_hsa034401.05560097
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98302358
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94764305
50RNA degradation_Homo sapiens_hsa030180.94082570
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93439527
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.90945197
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90043948
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.89780996
55Influenza A_Homo sapiens_hsa051640.89131535
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87257668
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87080077
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84830466
59Apoptosis_Homo sapiens_hsa042100.84107848
60Platelet activation_Homo sapiens_hsa046110.83565573
61Lysine degradation_Homo sapiens_hsa003100.81322416
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.79801315
63Leishmaniasis_Homo sapiens_hsa051400.79482970
64Epstein-Barr virus infection_Homo sapiens_hsa051690.79218449
65Dorso-ventral axis formation_Homo sapiens_hsa043200.78470705
66Adherens junction_Homo sapiens_hsa045200.77543601
67Toxoplasmosis_Homo sapiens_hsa051450.77520815
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76540698
69Choline metabolism in cancer_Homo sapiens_hsa052310.75923088
70Insulin resistance_Homo sapiens_hsa049310.74534836
71Insulin signaling pathway_Homo sapiens_hsa049100.74222850
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73897846
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.73333066
74Proteoglycans in cancer_Homo sapiens_hsa052050.73218802
75Melanoma_Homo sapiens_hsa052180.72902073
76Legionellosis_Homo sapiens_hsa051340.69590350
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68724803
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68101798
79Hepatitis C_Homo sapiens_hsa051600.67006866
80Osteoclast differentiation_Homo sapiens_hsa043800.66758222
81Hematopoietic cell lineage_Homo sapiens_hsa046400.64522116
82TNF signaling pathway_Homo sapiens_hsa046680.64380075
83TGF-beta signaling pathway_Homo sapiens_hsa043500.61905124
84Shigellosis_Homo sapiens_hsa051310.60904839
85N-Glycan biosynthesis_Homo sapiens_hsa005100.59440771
86Oocyte meiosis_Homo sapiens_hsa041140.54866828
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54155275
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53846853
89Pathways in cancer_Homo sapiens_hsa052000.52133757
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.50976526
91Primary immunodeficiency_Homo sapiens_hsa053400.49683187
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48919107
93Pyrimidine metabolism_Homo sapiens_hsa002400.48229132
94Viral myocarditis_Homo sapiens_hsa054160.47041938
95Selenocompound metabolism_Homo sapiens_hsa004500.45931017
96HIF-1 signaling pathway_Homo sapiens_hsa040660.45121296
97AMPK signaling pathway_Homo sapiens_hsa041520.44928727
98Allograft rejection_Homo sapiens_hsa053300.41711378
99Tuberculosis_Homo sapiens_hsa051520.41125321
100MAPK signaling pathway_Homo sapiens_hsa040100.39406329

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