THAP12P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)8.18508631
2B cell mediated immunity (GO:0019724)6.79801206
3thrombin receptor signaling pathway (GO:0070493)5.61613423
4neutrophil activation involved in immune response (GO:0002283)5.19091183
5positive thymic T cell selection (GO:0045059)4.74442575
6chaperone mediated protein folding requiring cofactor (GO:0051085)4.48273783
7positive regulation of type 2 immune response (GO:0002830)4.24210423
8positive regulation of natural killer cell differentiation (GO:0032825)4.14083850
9positive regulation of interleukin-17 production (GO:0032740)4.08891924
10xenobiotic catabolic process (GO:0042178)4.02979017
11mast cell activation (GO:0045576)4.00434811
12interferon-gamma-mediated signaling pathway (GO:0060333)3.99622002
13positive regulation of mast cell activation (GO:0033005)3.99602484
14positive T cell selection (GO:0043368)3.87535010
15lymphocyte costimulation (GO:0031294)3.87039096
16positive regulation of antigen processing and presentation (GO:0002579)3.82940555
17positive regulation of cellular amide metabolic process (GO:0034250)3.81514630
18T cell costimulation (GO:0031295)3.79104876
19positive regulation of interleukin-10 production (GO:0032733)3.73301013
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.72571267
21positive regulation of cAMP-mediated signaling (GO:0043950)3.72277358
22regulation of interleukin-10 production (GO:0032653)3.71597861
23regulation of mast cell activation (GO:0033003)3.69345570
24production of molecular mediator of immune response (GO:0002440)3.68946216
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.58611786
26blood coagulation, intrinsic pathway (GO:0007597)3.53247274
27negative regulation of heart rate (GO:0010459)3.52819152
28protein neddylation (GO:0045116)3.46742966
29regulation of antigen processing and presentation (GO:0002577)3.42295611
30keratinization (GO:0031424)3.38787762
31negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.38318952
32regulation of MHC class II biosynthetic process (GO:0045346)3.36696476
33negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.33507816
34negative regulation of T-helper cell differentiation (GO:0045623)3.33507816
35regulation of interleukin-17 production (GO:0032660)3.32510765
36regulation of interleukin-4 production (GO:0032673)3.30060135
37angiogenesis involved in wound healing (GO:0060055)3.29202484
38low-density lipoprotein particle remodeling (GO:0034374)3.28035366
39neutrophil activation (GO:0042119)3.27398526
40negative regulation of nitric oxide biosynthetic process (GO:0045019)3.24566433
41negative regulation of cAMP-mediated signaling (GO:0043951)3.18875665
42positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.17731554
43positive regulation of gamma-delta T cell activation (GO:0046645)3.16318979
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.14670620
45regulation of natural killer cell differentiation (GO:0032823)3.12828163
46regulation of hypersensitivity (GO:0002883)3.12577541
47positive regulation of activated T cell proliferation (GO:0042104)3.08112410
48positive regulation of natural killer cell mediated immunity (GO:0002717)3.06421361
49regulation of protein glycosylation (GO:0060049)3.05801638
50positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.05008189
51positive regulation of interleukin-8 secretion (GO:2000484)3.01968955
52regulation of platelet activation (GO:0010543)3.00276365
53relaxation of smooth muscle (GO:0044557)2.99659270
54negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94415216
55negative regulation of thymocyte apoptotic process (GO:0070244)2.94353178
56regulation of integrin activation (GO:0033623)2.93567608
57female mating behavior (GO:0060180)2.93470983
58cellular response to interferon-gamma (GO:0071346)2.90069318
59positive regulation of DNA-dependent DNA replication (GO:2000105)2.85697979
60regulation of activated T cell proliferation (GO:0046006)2.84212855
61regulation of T-helper 1 type immune response (GO:0002825)2.83009330
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82975653
63opioid receptor signaling pathway (GO:0038003)2.82893961
64ether lipid metabolic process (GO:0046485)2.79895313
65autophagic vacuole fusion (GO:0000046)2.79818674
66signal complex assembly (GO:0007172)2.79733966
67adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.79532977
68regulation of interleukin-8 secretion (GO:2000482)2.79387791
69T cell receptor signaling pathway (GO:0050852)2.79156437
70regulation of inflammatory response to antigenic stimulus (GO:0002861)2.78759452
71positive regulation of T-helper 1 type immune response (GO:0002827)2.78698271
72granulocyte activation (GO:0036230)2.76969100
73regulation of natural killer cell mediated immunity (GO:0002715)2.75965298
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.75965298
75triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.75694597
76negative T cell selection (GO:0043383)2.75528312
77negative thymic T cell selection (GO:0045060)2.74436192
78diol metabolic process (GO:0034311)2.74293316
79negative regulation of appetite (GO:0032099)2.73030839
80negative regulation of response to food (GO:0032096)2.73030839
81antigen receptor-mediated signaling pathway (GO:0050851)2.70736090
82regulation of T-helper 2 cell differentiation (GO:0045628)2.69071838
83positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.67310114
84positive regulation of cell cycle G2/M phase transition (GO:1902751)2.67310114
85sphingosine metabolic process (GO:0006670)2.66970426
86response to interferon-gamma (GO:0034341)2.66031058
87T cell activation involved in immune response (GO:0002286)2.65960878
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65688690
89L-phenylalanine catabolic process (GO:0006559)2.65370070
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.65370070
91lymphocyte mediated immunity (GO:0002449)2.64580317
92regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.63833413
93platelet aggregation (GO:0070527)2.63090707
94T-helper 1 type immune response (GO:0042088)2.62389839
95positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.60160316
96tyrosine phosphorylation of STAT protein (GO:0007260)2.57834888
97establishment of skin barrier (GO:0061436)2.56134157
98positive regulation of blood coagulation (GO:0030194)2.55461997
99positive regulation of hemostasis (GO:1900048)2.55461997
100defense response to protozoan (GO:0042832)2.54979299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.26180153
2VDR_22108803_ChIP-Seq_LS180_Human4.76272776
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.06009472
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.93184510
5SCL_19346495_ChIP-Seq_HPC-7_Human3.52476839
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.32420979
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86181693
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.84294044
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72738967
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.69526659
11SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.61253217
12RUNX_20019798_ChIP-Seq_JUKART_Human2.52563919
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.41240295
14EGR1_19032775_ChIP-ChIP_M12_Human2.39540254
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22940457
16TAF15_26573619_Chip-Seq_HEK293_Human2.22063164
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17429271
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.10231747
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09900352
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99955453
21LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.90686339
22GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75798148
23GATA3_27048872_Chip-Seq_THYMUS_Human1.70145834
24CIITA_25753668_ChIP-Seq_RAJI_Human1.69881304
25SPI1_23127762_ChIP-Seq_K562_Human1.66606602
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61678491
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.60615249
28STAT1_20625510_ChIP-Seq_HELA_Human1.57390355
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56291576
30NANOG_20526341_ChIP-Seq_ESCs_Human1.51529001
31SOX2_19829295_ChIP-Seq_ESCs_Human1.43282492
32NANOG_19829295_ChIP-Seq_ESCs_Human1.43282492
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42246898
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41358679
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41358679
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40416516
37SPI1_23547873_ChIP-Seq_NB4_Human1.39450616
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39265839
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38741191
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36957322
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35625481
42GATA3_26560356_Chip-Seq_TH2_Human1.35330106
43HTT_18923047_ChIP-ChIP_STHdh_Human1.31345506
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26384486
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24218259
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23246309
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.22768903
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19908404
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18513663
50MYB_26560356_Chip-Seq_TH2_Human1.18451202
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18315945
52GATA2_19941826_ChIP-Seq_K562_Human1.17729745
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.16683293
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15075652
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.14629671
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13883456
57CEBPB_22108803_ChIP-Seq_LS180_Human1.09900139
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09794224
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.08726231
60AR_20517297_ChIP-Seq_VCAP_Human1.07718680
61GATA1_19941826_ChIP-Seq_K562_Human1.07091397
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06105033
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04475044
64RXR_22108803_ChIP-Seq_LS180_Human1.03682624
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03045568
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.02437717
67RBPJ_21746931_ChIP-Seq_IB4_Human1.00778418
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00591347
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99988399
70SMAD_19615063_ChIP-ChIP_OVARY_Human0.99739757
71SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99283061
72SALL4_22934838_ChIP-ChIP_CD34+_Human0.99280119
73CRX_20693478_ChIP-Seq_RETINA_Mouse0.98077076
74TP53_22573176_ChIP-Seq_HFKS_Human0.97577666
75GATA6_21074721_ChIP-Seq_CACO-2_Human0.96403011
76GBX2_23144817_ChIP-Seq_PC3_Human0.95872431
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94945235
78ER_23166858_ChIP-Seq_MCF-7_Human0.94441900
79TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94396928
80EGR1_19374776_ChIP-ChIP_THP-1_Human0.93489452
81FLI1_21867929_ChIP-Seq_TH2_Mouse0.92471150
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91763303
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.91029008
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89734867
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89628671
86OCT1_27270436_Chip-Seq_PROSTATE_Human0.89287786
87MYB_26560356_Chip-Seq_TH1_Human0.89078631
88PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88974541
89GATA3_26560356_Chip-Seq_TH1_Human0.88254862
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88060102
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87932117
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85905111
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.85905111
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84783327
95P300_19829295_ChIP-Seq_ESCs_Human0.84324936
96TAF2_19829295_ChIP-Seq_ESCs_Human0.84291442
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.84267580
98EWS_26573619_Chip-Seq_HEK293_Human0.84248795
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83946883
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83584575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.17195666
2MP0001835_abnormal_antigen_presentation4.98284138
3MP0005451_abnormal_body_composition3.86824186
4MP0003183_abnormal_peptide_metabolism2.69320953
5MP0008004_abnormal_stomach_pH2.56612953
6MP0002148_abnormal_hypersensitivity_rea2.43753991
7MP0003950_abnormal_plasma_membrane2.39986806
8MP0002396_abnormal_hematopoietic_system2.36489983
9MP0001968_abnormal_touch/_nociception2.35727486
10MP0009764_decreased_sensitivity_to2.34829059
11MP0002876_abnormal_thyroid_physiology2.24665922
12MP0005000_abnormal_immune_tolerance2.22016089
13MP0001800_abnormal_humoral_immune2.03297005
14MP0009333_abnormal_splenocyte_physiolog2.03165601
15MP0003646_muscle_fatigue1.89609553
16MP0000465_gastrointestinal_hemorrhage1.85056975
17MP0003195_calcinosis1.84968208
18MP0010155_abnormal_intestine_physiology1.83017786
19MP0008872_abnormal_physiological_respon1.79342860
20MP0005646_abnormal_pituitary_gland1.78752190
21MP0002723_abnormal_immune_serum1.76805462
22MP0003656_abnormal_erythrocyte_physiolo1.74560501
23MP0005058_abnormal_lysosome_morphology1.74410994
24MP0005083_abnormal_biliary_tract1.73583695
25MP0002452_abnormal_antigen_presenting1.72716598
26MP0004036_abnormal_muscle_relaxation1.72543221
27MP0003300_gastrointestinal_ulcer1.65498650
28MP0002420_abnormal_adaptive_immunity1.63145123
29MP0002398_abnormal_bone_marrow1.60936414
30MP0002736_abnormal_nociception_after1.60784379
31MP0005167_abnormal_blood-brain_barrier1.60460881
32MP0001819_abnormal_immune_cell1.57578581
33MP0000230_abnormal_systemic_arterial1.57322775
34MP0005671_abnormal_response_to1.56942093
35MP0000343_altered_response_to1.52160993
36MP0003866_abnormal_defecation1.49940760
37MP0008775_abnormal_heart_ventricle1.42580501
38MP0000689_abnormal_spleen_morphology1.41126023
39MP0005551_abnormal_eye_electrophysiolog1.33276187
40MP0002796_impaired_skin_barrier1.33250345
41MP0002419_abnormal_innate_immunity1.30645728
42MP0001790_abnormal_immune_system1.30298368
43MP0005387_immune_system_phenotype1.30298368
44MP0008875_abnormal_xenobiotic_pharmacok1.28947139
45MP0005025_abnormal_response_to1.28669412
46MP0005360_urolithiasis1.28005663
47MP0009765_abnormal_xenobiotic_induced1.27200169
48MP0003724_increased_susceptibility_to1.26804000
49MP0001845_abnormal_inflammatory_respons1.24931631
50MP0004084_abnormal_cardiac_muscle1.23191197
51MP0000685_abnormal_immune_system1.21757729
52MP0000716_abnormal_immune_system1.20051457
53MP0005084_abnormal_gallbladder_morpholo1.17650295
54MP0003638_abnormal_response/metabolism_1.17049185
55MP0002429_abnormal_blood_cell1.16210170
56MP0001873_stomach_inflammation1.13470381
57MP0009785_altered_susceptibility_to1.10738639
58MP0002102_abnormal_ear_morphology1.10208532
59MP0008469_abnormal_protein_level1.09441213
60MP0002998_abnormal_bone_remodeling1.08197085
61MP0001664_abnormal_digestion1.07242720
62MP0009763_increased_sensitivity_to1.06588324
63MP0005410_abnormal_fertilization1.06014931
64MP0003436_decreased_susceptibility_to1.05365736
65MP0002722_abnormal_immune_system1.04925337
66MP0003786_premature_aging1.03151185
67MP0005365_abnormal_bile_salt1.01184126
68MP0002733_abnormal_thermal_nociception0.99114518
69MP0002837_dystrophic_cardiac_calcinosis0.99042109
70MP0002132_abnormal_respiratory_system0.98847494
71MP0003303_peritoneal_inflammation0.97862306
72MP0001501_abnormal_sleep_pattern0.97170757
73MP0003191_abnormal_cellular_cholesterol0.96673059
74MP0009278_abnormal_bone_marrow0.96129493
75MP0005670_abnormal_white_adipose0.96023534
76MP0003045_fibrosis0.94809288
77MP0008995_early_reproductive_senescence0.94183103
78MP0005408_hypopigmentation0.93880620
79MP0001663_abnormal_digestive_system0.93100415
80MP0005165_increased_susceptibility_to0.91367361
81MP0001533_abnormal_skeleton_physiology0.90968658
82MP0002405_respiratory_system_inflammati0.90872138
83MP0004947_skin_inflammation0.89086122
84MP0005501_abnormal_skin_physiology0.86367968
85MP0001851_eye_inflammation0.86131928
86MP0003941_abnormal_skin_development0.85910876
87MP0010329_abnormal_lipoprotein_level0.84967373
88MP0002693_abnormal_pancreas_physiology0.81609265
89MP0002139_abnormal_hepatobiliary_system0.81265733
90MP0003172_abnormal_lysosome_physiology0.80680043
91MP0009642_abnormal_blood_homeostasis0.79630214
92MP0004381_abnormal_hair_follicle0.77546419
93MP0000358_abnormal_cell_content/0.77317297
94MP0004883_abnormal_blood_vessel0.77280796
95MP0006072_abnormal_retinal_apoptosis0.73834327
96MP0001986_abnormal_taste_sensitivity0.71395945
97MP0002735_abnormal_chemical_nociception0.70897439
98MP0004142_abnormal_muscle_tone0.69697127
99MP0005397_hematopoietic_system_phenotyp0.69242326
100MP0001545_abnormal_hematopoietic_system0.69242326

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.27304017
2Menorrhagia (HP:0000132)6.13127384
3Purpura (HP:0000979)5.12421288
4Increased mean platelet volume (HP:0011877)5.08127566
5Epistaxis (HP:0000421)4.99048448
6Abnormal platelet volume (HP:0011876)4.70055909
7Petechiae (HP:0000967)4.52209725
8Hyperlipoproteinemia (HP:0010980)4.05528720
9Gingival bleeding (HP:0000225)3.97319049
10Abnormality of the prostate (HP:0008775)3.57376156
11Broad alveolar ridges (HP:0000187)3.54922740
12Decreased central vision (HP:0007663)3.47972190
13Inflammation of the large intestine (HP:0002037)3.31209002
14Pancreatic islet-cell hyperplasia (HP:0004510)3.30587537
15Thyroid-stimulating hormone excess (HP:0002925)3.15341783
16Increased IgM level (HP:0003496)3.04164071
17Impaired platelet aggregation (HP:0003540)2.98521941
18Abnormal platelet function (HP:0011869)2.98521941
19Gastrointestinal inflammation (HP:0004386)2.95714117
20Pulmonary infiltrates (HP:0002113)2.94822923
21Gangrene (HP:0100758)2.87964057
22Congenital stationary night blindness (HP:0007642)2.86824290
23Metaphyseal dysplasia (HP:0100255)2.85442225
24Abnormality of dental color (HP:0011073)2.77006338
25Mediastinal lymphadenopathy (HP:0100721)2.76147638
26Poikilocytosis (HP:0004447)2.75462122
27Neonatal respiratory distress (HP:0002643)2.70766753
28Recurrent abscess formation (HP:0002722)2.70172520
29Obstructive lung disease (HP:0006536)2.64877747
30Chronic obstructive pulmonary disease (HP:0006510)2.64877747
31Abnormality of the phalanges of the 2nd finger (HP:0009541)2.60473545
32Abnormality of proline metabolism (HP:0010907)2.52777858
33Hydroxyprolinuria (HP:0003080)2.52777858
34Abnormal pupillary function (HP:0007686)2.52774922
35Abnormality of the common coagulation pathway (HP:0010990)2.49462357
36Diastasis recti (HP:0001540)2.43617683
37Chest pain (HP:0100749)2.41930603
38Supernumerary ribs (HP:0005815)2.39100678
39Supernumerary bones of the axial skeleton (HP:0009144)2.37080725
40Acanthocytosis (HP:0001927)2.36353971
41Parakeratosis (HP:0001036)2.33223788
42Ureteral stenosis (HP:0000071)2.32486251
43Absent/shortened dynein arms (HP:0200106)2.32428419
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.32428419
45Colitis (HP:0002583)2.31044715
46Hypophosphatemic rickets (HP:0004912)2.30684191
47Acute lymphatic leukemia (HP:0006721)2.28967787
48Meningitis (HP:0001287)2.28769015
49Ureteral obstruction (HP:0006000)2.25511733
50Vaginal fistula (HP:0004320)2.25187642
51Joint hemorrhage (HP:0005261)2.24629066
52Urticaria (HP:0001025)2.23304072
53Short middle phalanx of the 5th finger (HP:0004220)2.22137792
54Erythema (HP:0010783)2.18940960
55Dyschromatopsia (HP:0007641)2.18862598
56Spontaneous hematomas (HP:0007420)2.17864899
57Xanthomatosis (HP:0000991)2.15720937
58Pulmonary embolism (HP:0002204)2.12141512
59Autoimmune hemolytic anemia (HP:0001890)2.09234664
60Xerostomia (HP:0000217)2.09026221
61Congenital, generalized hypertrichosis (HP:0004540)2.08792893
62Pulmonary fibrosis (HP:0002206)2.08104262
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.07616285
64Chronic diarrhea (HP:0002028)2.07541358
65Loss of speech (HP:0002371)2.05630345
66Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04692952
67Abnormality of the pleura (HP:0002103)2.04339295
68Panhypogammaglobulinemia (HP:0003139)2.03227730
69Rectovaginal fistula (HP:0000143)2.03212896
70Rectal fistula (HP:0100590)2.03212896
71Hypoplastic iliac wings (HP:0002866)2.02729501
72Abnormality of iron homeostasis (HP:0011031)2.02194539
73Abolished electroretinogram (ERG) (HP:0000550)2.01784202
74Encephalitis (HP:0002383)2.00753540
75Increased serum ferritin (HP:0003281)2.00481550
76Dysostosis multiplex (HP:0000943)1.97655741
77Spontaneous abortion (HP:0005268)1.97279644
78Abnormality of macrophages (HP:0004311)1.94198642
79Abnormality of transition element cation homeostasis (HP:0011030)1.92702923
80Hemorrhage of the eye (HP:0011885)1.91727341
81Abnormality of the alveolar ridges (HP:0006477)1.91544631
82Thrombophlebitis (HP:0004418)1.90493088
83Choroideremia (HP:0001139)1.88578396
84Glucose intolerance (HP:0000833)1.88386951
85Keratitis (HP:0000491)1.86644040
86Urinary glycosaminoglycan excretion (HP:0003541)1.84335881
87Mucopolysacchariduria (HP:0008155)1.84335881
88Abnormality of male internal genitalia (HP:0000022)1.83126214
89Thick nail (HP:0001805)1.82490016
90Keratoconus (HP:0000563)1.78611110
91Increased corneal curvature (HP:0100692)1.78611110
92Bruising susceptibility (HP:0000978)1.78165261
93Abnormality of the peritoneum (HP:0002585)1.77984306
94Alveolar cell carcinoma (HP:0006519)1.76883720
95Acute hepatic failure (HP:0006554)1.76830645
96Myocardial infarction (HP:0001658)1.76190321
97Abnormality of polysaccharide metabolism (HP:0011012)1.76163614
98Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76163614
99Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76163614
100Arterial thrombosis (HP:0004420)1.76039186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR25.08369664
2FLT34.45030792
3KIT3.94305614
4ADRBK23.54746055
5RIPK43.50258359
6EIF2AK13.12070788
7TLK12.88207351
8CSF1R2.79205824
9TAOK32.06628516
10MST42.01411261
11TXK2.01130449
12INSRR1.96391847
13TEC1.95238460
14SYK1.79368174
15IRAK11.76329030
16ZAK1.70294505
17JAK31.66661889
18EIF2AK31.62637653
19PIK3CG1.59870987
20FES1.55787322
21IRAK41.51623328
22ILK1.44215629
23NUAK11.41161326
24MAP4K11.38844166
25IKBKB1.38333565
26BTK1.33177308
27ZAP701.28587456
28KDR1.28056841
29STK241.23948677
30MAPKAPK31.17927158
31STK31.15901806
32MYLK1.13646453
33PTK2B1.10796128
34HCK1.09120587
35LYN1.08405058
36ADRBK11.07070119
37MARK30.99294555
38BMX0.97419267
39WNK40.96092903
40ERBB20.94998836
41PINK10.93590974
42ITK0.91905235
43TYRO30.90149466
44FRK0.89859852
45PKN10.88925267
46BMPR1B0.85630483
47SIK30.83767064
48MAP2K30.83669341
49ACVR1B0.80414315
50PNCK0.79915365
51GRK60.78325943
52PHKG10.76683576
53PHKG20.76683576
54PIM20.72732589
55TRPM70.72476219
56LCK0.68814303
57VRK10.68778586
58MATK0.68623784
59NME10.68406302
60GRK10.64987838
61PIM10.63156045
62GRK50.62594027
63PAK10.60959237
64CDK80.60693817
65EIF2AK20.59937835
66TYK20.57542851
67PRKCD0.54020951
68CCNB10.53349838
69MAPK110.53331363
70PRKCQ0.51309236
71IGF1R0.50641991
72NME20.49573408
73PRKCE0.48942869
74FER0.45292741
75DAPK30.41676392
76WNK10.39596423
77TAOK20.38961479
78IKBKE0.38948240
79TAOK10.38893843
80JAK20.37056391
81MAP2K10.36015025
82PRKG10.35917679
83TGFBR10.35783006
84GRK70.35616771
85IRAK30.35178658
86RPS6KA50.35086307
87PDGFRB0.34850968
88PRKCA0.34673340
89FGR0.34176270
90PRKACG0.33399097
91CSK0.32655663
92PRKCB0.29715991
93MAPK120.28815451
94CDK40.27607039
95AKT30.27467711
96ABL10.26539725
97IRAK20.25061998
98PLK20.23705595
99SGK20.23632648
100PRKAA20.22575442

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.36124702
2Allograft rejection_Homo sapiens_hsa053305.20720409
3Autoimmune thyroid disease_Homo sapiens_hsa053204.86095182
4Graft-versus-host disease_Homo sapiens_hsa053324.71118641
5Intestinal immune network for IgA production_Homo sapiens_hsa046724.36905170
6Type I diabetes mellitus_Homo sapiens_hsa049404.24680204
7Staphylococcus aureus infection_Homo sapiens_hsa051503.24487474
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.12022044
9Viral myocarditis_Homo sapiens_hsa054162.88819574
10Hematopoietic cell lineage_Homo sapiens_hsa046402.87640383
11Antigen processing and presentation_Homo sapiens_hsa046122.45334207
12Leishmaniasis_Homo sapiens_hsa051402.34543187
13Rheumatoid arthritis_Homo sapiens_hsa053232.20673610
14Systemic lupus erythematosus_Homo sapiens_hsa053221.90459646
15Platelet activation_Homo sapiens_hsa046111.60065284
16Toxoplasmosis_Homo sapiens_hsa051451.46589661
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27557761
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20070380
19Tuberculosis_Homo sapiens_hsa051521.14145862
20Herpes simplex infection_Homo sapiens_hsa051681.05835951
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.05377716
22Nitrogen metabolism_Homo sapiens_hsa009101.03590730
23Influenza A_Homo sapiens_hsa051641.00066033
24SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93626476
25Phagosome_Homo sapiens_hsa041450.88973598
26Primary immunodeficiency_Homo sapiens_hsa053400.87624626
27Arachidonic acid metabolism_Homo sapiens_hsa005900.86317921
28Linoleic acid metabolism_Homo sapiens_hsa005910.79052494
29Glutathione metabolism_Homo sapiens_hsa004800.70843917
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66799914
31B cell receptor signaling pathway_Homo sapiens_hsa046620.64835902
32T cell receptor signaling pathway_Homo sapiens_hsa046600.64582178
33Chemical carcinogenesis_Homo sapiens_hsa052040.64166194
34Phototransduction_Homo sapiens_hsa047440.62925928
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59279169
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58172508
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57851616
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.56697390
39Jak-STAT signaling pathway_Homo sapiens_hsa046300.53995760
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51666989
41Complement and coagulation cascades_Homo sapiens_hsa046100.50181753
42Olfactory transduction_Homo sapiens_hsa047400.50158516
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49441894
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48187764
45Sphingolipid metabolism_Homo sapiens_hsa006000.45350107
46Chemokine signaling pathway_Homo sapiens_hsa040620.44064854
47Starch and sucrose metabolism_Homo sapiens_hsa005000.42793519
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39527789
49Ether lipid metabolism_Homo sapiens_hsa005650.39318108
50Serotonergic synapse_Homo sapiens_hsa047260.38140275
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37695976
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36523354
53Measles_Homo sapiens_hsa051620.35427569
54Fat digestion and absorption_Homo sapiens_hsa049750.32205023
55Long-term depression_Homo sapiens_hsa047300.31780545
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29983979
57HTLV-I infection_Homo sapiens_hsa051660.29652245
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.28873934
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26860455
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25922008
61ABC transporters_Homo sapiens_hsa020100.25226835
62ECM-receptor interaction_Homo sapiens_hsa045120.24729709
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22202886
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.22139404
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21976695
66Morphine addiction_Homo sapiens_hsa050320.20533576
67Epstein-Barr virus infection_Homo sapiens_hsa051690.19917959
68Glycerolipid metabolism_Homo sapiens_hsa005610.18845185
69PPAR signaling pathway_Homo sapiens_hsa033200.18648789
70Circadian entrainment_Homo sapiens_hsa047130.17721217
71Ovarian steroidogenesis_Homo sapiens_hsa049130.16465940
72Malaria_Homo sapiens_hsa051440.16237200
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.14489216
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.14086776
75Salivary secretion_Homo sapiens_hsa049700.13723315
76Pancreatic secretion_Homo sapiens_hsa049720.12553820
77Pertussis_Homo sapiens_hsa051330.11397832
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10991271
79Oxytocin signaling pathway_Homo sapiens_hsa049210.10700738
80Lysosome_Homo sapiens_hsa041420.10440474
81Acute myeloid leukemia_Homo sapiens_hsa052210.09279636
82Collecting duct acid secretion_Homo sapiens_hsa049660.09205243
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.09196512
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.08568459
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08153738
86Legionellosis_Homo sapiens_hsa051340.08056340
87Osteoclast differentiation_Homo sapiens_hsa043800.07281899
88Circadian rhythm_Homo sapiens_hsa047100.06863117
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.06761297
90Ras signaling pathway_Homo sapiens_hsa040140.06372495
91Ribosome_Homo sapiens_hsa030100.05979164
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.05352430
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.05068667
94Renin secretion_Homo sapiens_hsa049240.04645945
95Alcoholism_Homo sapiens_hsa050340.03851397
96Oxidative phosphorylation_Homo sapiens_hsa001900.03836818
97Parkinsons disease_Homo sapiens_hsa050120.03700422
98Shigellosis_Homo sapiens_hsa051310.03647353
99Choline metabolism in cancer_Homo sapiens_hsa052310.03216562
100Calcium signaling pathway_Homo sapiens_hsa040200.02388128

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