THAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.47305976
2fucose catabolic process (GO:0019317)5.16152095
3L-fucose metabolic process (GO:0042354)5.16152095
4L-fucose catabolic process (GO:0042355)5.16152095
5definitive hemopoiesis (GO:0060216)4.94741437
6positive regulation of oligodendrocyte differentiation (GO:0048714)4.53764612
7nucleobase catabolic process (GO:0046113)4.44924662
8membrane tubulation (GO:0097320)4.32755431
9protein localization to cilium (GO:0061512)4.23479649
10fucosylation (GO:0036065)4.22174817
11fatty acid elongation (GO:0030497)3.91696827
12intraciliary transport (GO:0042073)3.87881541
13megakaryocyte development (GO:0035855)3.87086889
14sequestering of actin monomers (GO:0042989)3.81915134
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.81061826
16axon ensheathment in central nervous system (GO:0032291)3.73771040
17central nervous system myelination (GO:0022010)3.73771040
18pinocytosis (GO:0006907)3.70390657
19negative regulation of protein localization to cell surface (GO:2000009)3.63012693
20lymphoid progenitor cell differentiation (GO:0002320)3.62739497
21retinal ganglion cell axon guidance (GO:0031290)3.59679573
22auditory receptor cell differentiation (GO:0042491)3.59541673
23behavioral response to nicotine (GO:0035095)3.56156023
24negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.48394761
25glycosphingolipid biosynthetic process (GO:0006688)3.48045326
26DNA integration (GO:0015074)3.46581116
27epithelial cilium movement (GO:0003351)3.44556846
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36458004
29positive regulation of heat generation (GO:0031652)3.35896148
30regulation of heat generation (GO:0031650)3.32968066
31regulation of necroptotic process (GO:0060544)3.32685608
32presynaptic membrane assembly (GO:0097105)3.29670925
33nucleotide transmembrane transport (GO:1901679)3.29400764
34RNA destabilization (GO:0050779)3.27347220
35somite development (GO:0061053)3.26300219
36negative regulation of necroptotic process (GO:0060546)3.22554009
37negative regulation of osteoblast proliferation (GO:0033689)3.21440063
38transmission of nerve impulse (GO:0019226)3.20070740
39regulation of cilium movement (GO:0003352)3.19549481
40oligodendrocyte differentiation (GO:0048709)3.19089236
41regulation of somitogenesis (GO:0014807)3.18771739
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18729395
43photoreceptor cell differentiation (GO:0046530)3.18076644
44eye photoreceptor cell differentiation (GO:0001754)3.18076644
45tachykinin receptor signaling pathway (GO:0007217)3.18047439
46signal peptide processing (GO:0006465)3.17682255
47positive regulation of mitochondrial fission (GO:0090141)3.16577098
48peptidyl-histidine modification (GO:0018202)3.12738603
49protein polyglutamylation (GO:0018095)3.12106664
50regulation of fever generation (GO:0031620)3.11918255
51cell proliferation involved in metanephros development (GO:0072203)3.11182255
52positive regulation of cellular amine metabolic process (GO:0033240)3.10416532
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06580593
54preassembly of GPI anchor in ER membrane (GO:0016254)3.05487861
55negative regulation of telomere maintenance (GO:0032205)3.05076180
56neuron cell-cell adhesion (GO:0007158)3.03493303
57cell proliferation involved in kidney development (GO:0072111)3.03302875
58presynaptic membrane organization (GO:0097090)3.00788617
59synapse assembly (GO:0007416)2.98437421
60calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.98024401
61mannosylation (GO:0097502)2.97964479
62cilium assembly (GO:0042384)2.93916742
63cilium morphogenesis (GO:0060271)2.93408310
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92519811
65regulation of mesenchymal cell apoptotic process (GO:2001053)2.91653504
66positive regulation of macrophage differentiation (GO:0045651)2.91100285
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90645946
68fucose metabolic process (GO:0006004)2.90382952
69positive regulation of cellular amide metabolic process (GO:0034250)2.90161467
70cilium organization (GO:0044782)2.89917576
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89636523
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.89636523
73NADH dehydrogenase complex assembly (GO:0010257)2.89636523
74regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.89233219
75axoneme assembly (GO:0035082)2.88501513
76inner ear receptor cell differentiation (GO:0060113)2.88315591
77platelet dense granule organization (GO:0060155)2.87106541
78behavioral response to ethanol (GO:0048149)2.87078134
79axonal fasciculation (GO:0007413)2.87008193
80protein complex biogenesis (GO:0070271)2.86833521
81forebrain neuron differentiation (GO:0021879)2.86194285
82neuron fate determination (GO:0048664)2.86164158
83regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85008298
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82359172
85long-chain fatty acid biosynthetic process (GO:0042759)2.82316710
86negative regulation of alpha-beta T cell differentiation (GO:0046639)2.81179627
87olfactory bulb development (GO:0021772)2.81132887
88limb bud formation (GO:0060174)2.80974352
89peripheral nervous system neuron development (GO:0048935)2.80559239
90ganglion development (GO:0061548)2.80045724
91regulation of collateral sprouting (GO:0048670)2.79558730
92acrosome reaction (GO:0007340)2.78766825
93negative regulation of oligodendrocyte differentiation (GO:0048715)2.76581949
94DNA topological change (GO:0006265)2.76471773
95positive regulation of granulocyte differentiation (GO:0030854)2.75990470
96melanosome transport (GO:0032402)2.75912611
97cilium movement (GO:0003341)2.75491847
98establishment of melanosome localization (GO:0032401)2.74657781
99ionotropic glutamate receptor signaling pathway (GO:0035235)2.74186405
100C-terminal protein lipidation (GO:0006501)2.71650727
101secretory granule organization (GO:0033363)2.70752547
102positive regulation of protein homodimerization activity (GO:0090073)2.70695267
103dendritic spine morphogenesis (GO:0060997)2.70477886
104neural tube formation (GO:0001841)2.69796764
105synaptic transmission, glutamatergic (GO:0035249)2.69269277
106kynurenine metabolic process (GO:0070189)2.69168022
107mesenchymal cell differentiation involved in renal system development (GO:2001012)2.68595391
108mesenchymal cell differentiation involved in kidney development (GO:0072161)2.68595391
109inner ear receptor stereocilium organization (GO:0060122)2.67825724
110pigment granule transport (GO:0051904)2.65806680
111organelle disassembly (GO:1903008)2.65803019
112establishment of pigment granule localization (GO:0051905)2.65045796
113photoreceptor cell maintenance (GO:0045494)2.64919326
114hepatocyte apoptotic process (GO:0097284)2.64043165
115regulation of pigment cell differentiation (GO:0050932)2.63577833
116neuron recognition (GO:0008038)2.63140887
117mitotic sister chromatid cohesion (GO:0007064)2.62592268
118glutamate receptor signaling pathway (GO:0007215)2.62252559
119nonmotile primary cilium assembly (GO:0035058)2.61188990
120hippocampus development (GO:0021766)2.59533440
121negative regulation of T cell apoptotic process (GO:0070233)2.59259195
122ceramide catabolic process (GO:0046514)2.58922103
123programmed necrotic cell death (GO:0097300)2.58753650
124C4-dicarboxylate transport (GO:0015740)2.58607572
125regulation of DNA endoreduplication (GO:0032875)2.58393117
126startle response (GO:0001964)2.57788858
127positive regulation of Notch signaling pathway (GO:0045747)2.57175320
128regulation of feeding behavior (GO:0060259)2.56416778
129lymph node development (GO:0048535)2.56361469
130negative regulation of systemic arterial blood pressure (GO:0003085)2.55389267
131positive regulation of amino acid transport (GO:0051957)2.55125314
132sympathetic nervous system development (GO:0048485)2.54333694
133ether lipid metabolic process (GO:0046485)2.54215758
134cilium or flagellum-dependent cell motility (GO:0001539)2.54002287
135regulation of telomere maintenance (GO:0032204)2.53717911
136response to pheromone (GO:0019236)2.53330310
137T cell homeostasis (GO:0043029)2.51089753
138mechanosensory behavior (GO:0007638)2.50882533
1393-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.50468526
140purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.50468526
141G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.50416780
142neuron-neuron synaptic transmission (GO:0007270)2.50380432
143positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.49749817
144gamma-aminobutyric acid transport (GO:0015812)2.49347365
145neuronal action potential (GO:0019228)2.49220859
146indole-containing compound catabolic process (GO:0042436)2.49087910
147indolalkylamine catabolic process (GO:0046218)2.49087910
148tryptophan catabolic process (GO:0006569)2.49087910
149positive regulation of synaptic transmission, GABAergic (GO:0032230)2.48624009
150regulation of microtubule-based movement (GO:0060632)2.46927917
151DNA double-strand break processing (GO:0000729)2.46843881
152mitochondrial respiratory chain complex assembly (GO:0033108)2.46795614
153auditory behavior (GO:0031223)2.45416584
154positive regulation of potassium ion transmembrane transport (GO:1901381)2.45228654
155indolalkylamine metabolic process (GO:0006586)2.44764005
156regulation of development, heterochronic (GO:0040034)2.44605564
157amine catabolic process (GO:0009310)2.44220652
158cellular biogenic amine catabolic process (GO:0042402)2.44220652
159central nervous system projection neuron axonogenesis (GO:0021952)2.44200944
160T-helper 1 type immune response (GO:0042088)2.42470245
161glycosphingolipid catabolic process (GO:0046479)2.42031281
162cell differentiation involved in metanephros development (GO:0072202)2.41463570
163DNA ligation (GO:0006266)2.40768543
164regulation of respiratory burst (GO:0060263)2.39284936
165regulation of cell proliferation involved in kidney development (GO:1901722)2.37879779
166daunorubicin metabolic process (GO:0044597)2.37429024
167polyketide metabolic process (GO:0030638)2.37429024
168doxorubicin metabolic process (GO:0044598)2.37429024
169nucleotide transport (GO:0006862)2.36915592
170negative regulation of myoblast differentiation (GO:0045662)2.36456864
171mast cell activation (GO:0045576)2.35561952
172regulation of T cell migration (GO:2000404)2.35487336
173positive regulation of T cell cytokine production (GO:0002726)2.33659133
174T cell differentiation in thymus (GO:0033077)2.33467822
175positive regulation of T cell migration (GO:2000406)2.33420837
176cell proliferation in forebrain (GO:0021846)2.32977275
177glycosylceramide metabolic process (GO:0006677)2.31430082
178glycolipid catabolic process (GO:0019377)2.30277636
179GPI anchor biosynthetic process (GO:0006506)2.30063053
180cerebral cortex radially oriented cell migration (GO:0021799)2.29968642
181neutrophil mediated immunity (GO:0002446)2.29955386
182positive regulation of T cell mediated cytotoxicity (GO:0001916)2.29425471
183developmental pigmentation (GO:0048066)2.29021050
184response to prostaglandin E (GO:0034695)2.28294662
185establishment of tissue polarity (GO:0007164)2.27989632
186establishment of planar polarity (GO:0001736)2.27989632
187CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.27679195
188isoprenoid biosynthetic process (GO:0008299)2.27438535
189magnesium ion transport (GO:0015693)2.27407429
190necroptotic process (GO:0070266)2.27048200
191positive regulation of glial cell differentiation (GO:0045687)2.25380604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.36709182
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.32276318
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.28387349
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.40113502
5ZNF274_21170338_ChIP-Seq_K562_Hela2.88037356
6E2F7_22180533_ChIP-Seq_HELA_Human2.87784810
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.80204776
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.76981531
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72359932
10EZH2_22144423_ChIP-Seq_EOC_Human2.52241210
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.50233247
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47472170
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47145833
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38617721
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33701993
16GATA1_22025678_ChIP-Seq_K562_Human2.31770816
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29635946
18GBX2_23144817_ChIP-Seq_PC3_Human2.29099398
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.21546493
20SCL_19346495_ChIP-Seq_HPC-7_Human2.17913919
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11590427
22VDR_22108803_ChIP-Seq_LS180_Human2.09825143
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09704704
24IRF1_19129219_ChIP-ChIP_H3396_Human2.06786666
25IGF1R_20145208_ChIP-Seq_DFB_Human2.00004398
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.97520383
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97206610
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81893337
29EWS_26573619_Chip-Seq_HEK293_Human1.79590999
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79025331
31TAF15_26573619_Chip-Seq_HEK293_Human1.77949861
32SMAD4_21799915_ChIP-Seq_A2780_Human1.75595226
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70403763
34* GABP_17652178_ChIP-ChIP_JURKAT_Human1.70057500
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69482907
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66109685
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64015122
38CBP_20019798_ChIP-Seq_JUKART_Human1.64015122
39RUNX_20019798_ChIP-Seq_JUKART_Human1.60523279
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58906741
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58432588
42RNF2_27304074_Chip-Seq_NSC_Mouse1.58259261
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57235687
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57099087
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.53397684
46REST_21632747_ChIP-Seq_MESCs_Mouse1.51501687
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51272727
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51184337
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51065649
50AR_25329375_ChIP-Seq_VCAP_Human1.49231565
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46739438
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41803665
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.40523466
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40182129
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.38766079
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38418703
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.37822520
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37811556
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37796842
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37788486
61FUS_26573619_Chip-Seq_HEK293_Human1.37045619
62* EST1_17652178_ChIP-ChIP_JURKAT_Human1.37034485
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36843104
64ER_23166858_ChIP-Seq_MCF-7_Human1.35515546
65P53_22387025_ChIP-Seq_ESCs_Mouse1.34160998
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.33670032
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30949758
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.30932115
69STAT3_23295773_ChIP-Seq_U87_Human1.30596376
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.29594524
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28720836
72ELK1_19687146_ChIP-ChIP_HELA_Human1.28680278
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28515024
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28371763
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28100570
76NMYC_18555785_Chip-Seq_ESCs_Mouse1.27736205
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.27392479
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.26928489
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26129392
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25657100
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25596063
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24813880
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.24635638
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23202850
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.22581425
86RUNX2_22187159_ChIP-Seq_PCA_Human1.22281581
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21470002
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21111821
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19835211
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.19735808
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19382210
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19213117
93TCF4_23295773_ChIP-Seq_U87_Human1.18492526
94P300_18555785_Chip-Seq_ESCs_Mouse1.17606939
95TP53_22573176_ChIP-Seq_HFKS_Human1.17237640
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16815768
97RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15757169
98SOX2_19829295_ChIP-Seq_ESCs_Human1.15432306
99NANOG_19829295_ChIP-Seq_ESCs_Human1.15432306
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14374070
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14196362
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.14015638
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.13756213
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13285958
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.12786169
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.12754484
107JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12689621
108MYC_18940864_ChIP-ChIP_HL60_Human1.12467935
109P300_19829295_ChIP-Seq_ESCs_Human1.11843369
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10860073
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10392283
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.09749373
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.09570777
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.09452340
115KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09055685
116PU1_27457419_Chip-Seq_LIVER_Mouse1.08274254
117NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07434861
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07075817
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06894617
120TP53_18474530_ChIP-ChIP_U2OS_Human1.06765379
121ZFX_18555785_Chip-Seq_ESCs_Mouse1.06687924
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06451422
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.06400931
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.06348754
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.04111552
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03250533
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03213879
128MYB_26560356_Chip-Seq_TH2_Human1.02385514
129IRF8_21731497_ChIP-ChIP_J774_Mouse1.01739016
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00845586
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00845109
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00716656
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00453063
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98570731
135HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98141043
136FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98036839
137VDR_24763502_ChIP-Seq_THP-1_Human0.97681845
138TP63_19390658_ChIP-ChIP_HaCaT_Human0.97451860
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94756784
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94555580
141FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94168004
142* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94005605
143EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93656538
144KLF4_18555785_Chip-Seq_ESCs_Mouse0.93378563
145SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93052559
146LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91502694
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90454303
148ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89160787
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89042183
150POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88627334
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88627334
152SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88479558
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87527941
154PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87374280
155SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86728777
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86175136
157IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85820069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.76713051
2MP0002396_abnormal_hematopoietic_system3.60407613
3MP0006054_spinal_hemorrhage3.56048524
4MP0005174_abnormal_tail_pigmentation3.43416580
5MP0000566_synostosis3.28575175
6MP0003183_abnormal_peptide_metabolism2.96576695
7MP0002938_white_spotting2.88267450
8MP0005075_abnormal_melanosome_morpholog2.75689488
9MP0001529_abnormal_vocalization2.74129229
10MP0003763_abnormal_thymus_physiology2.69855081
11MP0002736_abnormal_nociception_after2.61585928
12MP0006072_abnormal_retinal_apoptosis2.57528287
13MP0003880_abnormal_central_pattern2.49237917
14MP0006292_abnormal_olfactory_placode2.40389245
15MP0002735_abnormal_chemical_nociception2.40067111
16MP0000685_abnormal_immune_system2.35716021
17MP0005253_abnormal_eye_physiology2.33427056
18MP0001968_abnormal_touch/_nociception2.29482766
19MP0002095_abnormal_skin_pigmentation2.28639658
20MP0009046_muscle_twitch2.25904182
21MP0003195_calcinosis2.23745499
22MP0004270_analgesia2.16775298
23MP0002102_abnormal_ear_morphology2.15505852
24MP0002653_abnormal_ependyma_morphology2.03041557
25MP0001835_abnormal_antigen_presentation2.00997674
26MP0005220_abnormal_exocrine_pancreas1.99480691
27MP0006276_abnormal_autonomic_nervous1.98488064
28MP0000015_abnormal_ear_pigmentation1.94890754
29MP0005394_taste/olfaction_phenotype1.94767006
30MP0005499_abnormal_olfactory_system1.94767006
31MP0009745_abnormal_behavioral_response1.94693253
32MP0002272_abnormal_nervous_system1.94000645
33MP0000465_gastrointestinal_hemorrhage1.89822249
34MP0004142_abnormal_muscle_tone1.86197924
35MP0002009_preneoplasia1.85868028
36MP0003938_abnormal_ear_development1.83131513
37MP0002734_abnormal_mechanical_nocicepti1.79007352
38MP0002572_abnormal_emotion/affect_behav1.77885951
39MP0005167_abnormal_blood-brain_barrier1.77487504
40MP0004859_abnormal_synaptic_plasticity1.76733662
41MP0005551_abnormal_eye_electrophysiolog1.70930237
42MP0000372_irregular_coat_pigmentation1.69059148
43MP0000920_abnormal_myelination1.68645111
44MP0004147_increased_porphyrin_level1.67730480
45MP0003635_abnormal_synaptic_transmissio1.67063511
46MP0003890_abnormal_embryonic-extraembry1.66950438
47MP0002166_altered_tumor_susceptibility1.66131818
48MP0001486_abnormal_startle_reflex1.65150140
49MP0002063_abnormal_learning/memory/cond1.62103639
50MP0008007_abnormal_cellular_replicative1.61426432
51MP0002837_dystrophic_cardiac_calcinosis1.60487040
52MP0001970_abnormal_pain_threshold1.60457038
53MP0003943_abnormal_hepatobiliary_system1.58816449
54MP0005423_abnormal_somatic_nervous1.58368877
55MP0008995_early_reproductive_senescence1.57105188
56MP0003787_abnormal_imprinting1.57027231
57MP0001293_anophthalmia1.56923331
58MP0002148_abnormal_hypersensitivity_rea1.56349859
59MP0004742_abnormal_vestibular_system1.56064589
60MP0002064_seizures1.55805727
61MP0003122_maternal_imprinting1.55742815
62MP0002067_abnormal_sensory_capabilities1.55706996
63MP0004133_heterotaxia1.55548269
64MP0002751_abnormal_autonomic_nervous1.52141150
65MP0008789_abnormal_olfactory_epithelium1.51372303
66MP0002557_abnormal_social/conspecific_i1.49569363
67MP0005671_abnormal_response_to1.48885918
68MP0008877_abnormal_DNA_methylation1.48045441
69MP0005386_behavior/neurological_phenoty1.45465487
70MP0004924_abnormal_behavior1.45465487
71MP0005084_abnormal_gallbladder_morpholo1.40974904
72MP0000613_abnormal_salivary_gland1.39046767
73MP0002163_abnormal_gland_morphology1.35379815
74MP0001188_hyperpigmentation1.34343362
75MP0001501_abnormal_sleep_pattern1.33315657
76MP0005379_endocrine/exocrine_gland_phen1.33245588
77MP0002733_abnormal_thermal_nociception1.33170708
78MP0003121_genomic_imprinting1.28174784
79MP0002398_abnormal_bone_marrow1.27782014
80MP0001905_abnormal_dopamine_level1.27766499
81MP0005503_abnormal_tendon_morphology1.26806060
82MP0002184_abnormal_innervation1.26585477
83MP0000955_abnormal_spinal_cord1.24537177
84MP0004885_abnormal_endolymph1.24525248
85MP0003136_yellow_coat_color1.23564908
86MP0000383_abnormal_hair_follicle1.23543329
87MP0005248_abnormal_Harderian_gland1.22597816
88MP0001790_abnormal_immune_system1.20483585
89MP0005387_immune_system_phenotype1.20483585
90MP0003937_abnormal_limbs/digits/tail_de1.19735039
91MP0005410_abnormal_fertilization1.18916427
92MP0000778_abnormal_nervous_system1.18649341
93MP0005464_abnormal_platelet_physiology1.18432556
94MP0008057_abnormal_DNA_replication1.18086605
95MP0001800_abnormal_humoral_immune1.17807053
96MP0002234_abnormal_pharynx_morphology1.17724901
97MP0000049_abnormal_middle_ear1.17517622
98MP0002882_abnormal_neuron_morphology1.17511965
99MP0004811_abnormal_neuron_physiology1.17001448
100MP0009785_altered_susceptibility_to1.16783634
101MP0005645_abnormal_hypothalamus_physiol1.12590401
102MP0001873_stomach_inflammation1.11387014
103MP0000703_abnormal_thymus_morphology1.11209540
104MP0003385_abnormal_body_wall1.10923942
105MP0002420_abnormal_adaptive_immunity1.10709256
106MP0005195_abnormal_posterior_eye1.10675850
107MP0001485_abnormal_pinna_reflex1.10086284
108MP0000716_abnormal_immune_system1.09435266
109MP0002452_abnormal_antigen_presenting1.09371992
110MP0002723_abnormal_immune_serum1.08561593
111MP0002177_abnormal_outer_ear1.08105291
112MP0001324_abnormal_eye_pigmentation1.07557477
113MP0005391_vision/eye_phenotype1.07506022
114MP0002638_abnormal_pupillary_reflex1.06846316
115MP0003646_muscle_fatigue1.06741902
116MP0001819_abnormal_immune_cell1.06315875
117MP0002752_abnormal_somatic_nervous1.06145868
118MP0001919_abnormal_reproductive_system1.06007906
119MP0002006_tumorigenesis1.05999291
120MP0002928_abnormal_bile_duct1.05648926
121MP0005187_abnormal_penis_morphology1.05500471
122MP0003868_abnormal_feces_composition1.04812166
123MP0009697_abnormal_copulation1.03854973
124MP0003011_delayed_dark_adaptation1.01951995
125MP0001984_abnormal_olfaction0.99499224
126MP0001986_abnormal_taste_sensitivity0.99395136
127MP0000689_abnormal_spleen_morphology0.98689990
128MP0004808_abnormal_hematopoietic_stem0.96911974
129MP0002429_abnormal_blood_cell0.96275002
130MP0003137_abnormal_impulse_conducting0.95795306
131MP0002075_abnormal_coat/hair_pigmentati0.94989641
132MP0005409_darkened_coat_color0.93668898
133MP0002277_abnormal_respiratory_mucosa0.92717975
134MP0000631_abnormal_neuroendocrine_gland0.92624242
135MP0003633_abnormal_nervous_system0.91641287
136MP0004043_abnormal_pH_regulation0.91224971
137MP0002419_abnormal_innate_immunity0.90843779
138MP0009250_abnormal_appendicular_skeleto0.90536365
139MP0005000_abnormal_immune_tolerance0.90206033
140MP0001186_pigmentation_phenotype0.90067294
141MP0002098_abnormal_vibrissa_morphology0.89932642
142MP0002722_abnormal_immune_system0.89890643
143MP0005025_abnormal_response_to0.89616671
144MP0003300_gastrointestinal_ulcer0.89191929
145MP0003303_peritoneal_inflammation0.88402871
146MP0004134_abnormal_chest_morphology0.88098959
147MP0009764_decreased_sensitivity_to0.87891145
148MP0001440_abnormal_grooming_behavior0.87085854
149MP0005646_abnormal_pituitary_gland0.87038018
150MP0002229_neurodegeneration0.86638109
151MP0003724_increased_susceptibility_to0.86514595
152MP0002933_joint_inflammation0.85232674
153MP0000371_diluted_coat_color0.84769146
154MP0000026_abnormal_inner_ear0.84534040
155MP0003279_aneurysm0.84035975
156MP0000462_abnormal_digestive_system0.83184043
157MP0003698_abnormal_male_reproductive0.82044966
158MP0002090_abnormal_vision0.80881251
159MP0002233_abnormal_nose_morphology0.80728880
160MP0003119_abnormal_digestive_system0.80342963
161MP0002282_abnormal_trachea_morphology0.79869898
162MP0002152_abnormal_brain_morphology0.79852996
163MP0000516_abnormal_urinary_system0.79323018
164MP0005367_renal/urinary_system_phenotyp0.79323018
165MP0002822_catalepsy0.78866074
166MP0002332_abnormal_exercise_endurance0.78738102
167MP0001270_distended_abdomen0.78684496
168MP0000490_abnormal_crypts_of0.78024551
169MP0002092_abnormal_eye_morphology0.77119069
170MP0001346_abnormal_lacrimal_gland0.75679438
171MP0005171_absent_coat_pigmentation0.74897701
172MP0002876_abnormal_thyroid_physiology0.74127790
173MP0009333_abnormal_splenocyte_physiolog0.72331925
174MP0003866_abnormal_defecation0.71636523
175MP0002932_abnormal_joint_morphology0.71453430
176MP0010386_abnormal_urinary_bladder0.71375242

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.99293650
2Gait imbalance (HP:0002141)3.83620579
3Congenital primary aphakia (HP:0007707)3.63792842
4Abnormality of the fingertips (HP:0001211)3.49665705
5Nephrogenic diabetes insipidus (HP:0009806)3.32966229
6Chromsome breakage (HP:0040012)3.17185579
7Nephronophthisis (HP:0000090)3.16537359
8True hermaphroditism (HP:0010459)3.16534413
9Molar tooth sign on MRI (HP:0002419)3.16517350
10Abnormality of midbrain morphology (HP:0002418)3.16517350
11Prolonged bleeding time (HP:0003010)3.16428752
12White forelock (HP:0002211)3.15736775
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05660384
14Retinal dysplasia (HP:0007973)2.98679760
15Aplastic anemia (HP:0001915)2.97263737
16Genital tract atresia (HP:0001827)2.95454118
17Thyroid-stimulating hormone excess (HP:0002925)2.94720355
18Limb dystonia (HP:0002451)2.91726067
19Patchy hypopigmentation of hair (HP:0011365)2.89298194
20Type II lissencephaly (HP:0007260)2.80503944
213-Methylglutaconic aciduria (HP:0003535)2.80406080
22Vaginal atresia (HP:0000148)2.77500024
23Lipid accumulation in hepatocytes (HP:0006561)2.76955825
24Hemiparesis (HP:0001269)2.75286716
25Tubulointerstitial nephritis (HP:0001970)2.72620913
26Volvulus (HP:0002580)2.71827103
27Polyphagia (HP:0002591)2.71274907
28Tented upper lip vermilion (HP:0010804)2.70566819
29Increased hepatocellular lipid droplets (HP:0006565)2.69809014
30Recurrent pneumonia (HP:0006532)2.69287587
31Gastrointestinal stroma tumor (HP:0100723)2.68663903
32Abnormality of the renal medulla (HP:0100957)2.60290381
33Febrile seizures (HP:0002373)2.57990676
34Drooling (HP:0002307)2.49805109
35Hyperventilation (HP:0002883)2.47420991
36Acute necrotizing encephalopathy (HP:0006965)2.45961728
37Chronic diarrhea (HP:0002028)2.42955021
38Abnormality of the columella (HP:0009929)2.42123965
39Poor coordination (HP:0002370)2.41857065
40Recurrent bronchitis (HP:0002837)2.41757061
41Specific learning disability (HP:0001328)2.41088699
42Agammaglobulinemia (HP:0004432)2.40396797
43Flared iliac wings (HP:0002869)2.39469510
44Congenital sensorineural hearing impairment (HP:0008527)2.38860043
45Absent speech (HP:0001344)2.37517108
46Abnormality of the renal cortex (HP:0011035)2.35827759
47Abolished electroretinogram (ERG) (HP:0000550)2.34791780
48Generalized aminoaciduria (HP:0002909)2.32328899
49Progressive macrocephaly (HP:0004481)2.31337442
50Fair hair (HP:0002286)2.31170819
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.31167289
52Pachygyria (HP:0001302)2.30503607
53Type I transferrin isoform profile (HP:0003642)2.30430563
54Thrombocytosis (HP:0001894)2.29853212
55Dyschromatopsia (HP:0007641)2.29766229
56Abnormality of B cell number (HP:0010975)2.29491473
57B lymphocytopenia (HP:0010976)2.29491473
58Cerebellar dysplasia (HP:0007033)2.29488678
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.29233610
60Chronic otitis media (HP:0000389)2.28344061
61Gingival bleeding (HP:0000225)2.27136102
62Excessive salivation (HP:0003781)2.25693360
63Mitochondrial inheritance (HP:0001427)2.25466867
64IgM deficiency (HP:0002850)2.25455229
65Anencephaly (HP:0002323)2.22707971
66Lissencephaly (HP:0001339)2.21255029
67Progressive cerebellar ataxia (HP:0002073)2.21035197
68Chronic hepatic failure (HP:0100626)2.20903896
69Reduced antithrombin III activity (HP:0001976)2.20830471
70Broad-based gait (HP:0002136)2.20634477
71Increased corneal curvature (HP:0100692)2.20239511
72Keratoconus (HP:0000563)2.20239511
73Increased CSF lactate (HP:0002490)2.17702136
74Amyotrophic lateral sclerosis (HP:0007354)2.17544854
75Postaxial hand polydactyly (HP:0001162)2.17034915
76Short tibia (HP:0005736)2.16819054
77Lip pit (HP:0100267)2.16118200
78Abnormality of proline metabolism (HP:0010907)2.15313875
79Hydroxyprolinuria (HP:0003080)2.15313875
80Focal motor seizures (HP:0011153)2.14486472
81Pancreatic cysts (HP:0001737)2.13570772
82Abnormal respiratory epithelium morphology (HP:0012253)2.13217519
83Abnormal respiratory motile cilium morphology (HP:0005938)2.13217519
84Abnormal protein glycosylation (HP:0012346)2.12636390
85Abnormal glycosylation (HP:0012345)2.12636390
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12636390
87Abnormal protein N-linked glycosylation (HP:0012347)2.12636390
88Epistaxis (HP:0000421)2.12598565
89Congenital stationary night blindness (HP:0007642)2.12175671
90Periodontitis (HP:0000704)2.12161370
91Optic nerve hypoplasia (HP:0000609)2.11725675
92Intestinal atresia (HP:0011100)2.10992968
93Abnormality of the labia minora (HP:0012880)2.10853631
94Parakeratosis (HP:0001036)2.10530167
95Palpebral edema (HP:0100540)2.09670000
96Aortic regurgitation (HP:0001659)2.09569921
97Abnormal mitochondria in muscle tissue (HP:0008316)2.07697535
98Atrophy/Degeneration involving motor neurons (HP:0007373)2.07042231
99Abnormality of the lumbar spine (HP:0100712)2.06369810
100Optic nerve coloboma (HP:0000588)2.06337209
101Polydipsia (HP:0001959)2.04759366
102Abnormal drinking behavior (HP:0030082)2.04759366
103Delayed CNS myelination (HP:0002188)2.04306533
104Diastasis recti (HP:0001540)2.03716419
105Papilledema (HP:0001085)2.03152799
106Acute encephalopathy (HP:0006846)2.02152657
107Abnormal delayed hypersensitivity skin test (HP:0002963)2.01955325
108Aplasia/Hypoplasia of the lens (HP:0008063)2.00879468
109Broad foot (HP:0001769)2.00786763
110Myokymia (HP:0002411)2.00637438
111Abnormality of the renal collecting system (HP:0004742)2.00328633
112Thickened calvaria (HP:0002684)1.99978408
113Ectopic kidney (HP:0000086)1.99126446
114Reticulocytopenia (HP:0001896)1.98662658
115Craniofacial hyperostosis (HP:0004493)1.98148783
116Lymphopenia (HP:0001888)1.97462775
117Epileptic encephalopathy (HP:0200134)1.97197742
118Bony spicule pigmentary retinopathy (HP:0007737)1.95371844
119Tubulointerstitial abnormality (HP:0001969)1.94467051
120Atonic seizures (HP:0010819)1.94210681
121Sclerocornea (HP:0000647)1.93511715
122Portal hypertension (HP:0001409)1.92131507
123Hypoproteinemia (HP:0003075)1.90063563
124Long eyelashes (HP:0000527)1.89142455
125Spastic tetraplegia (HP:0002510)1.89067243
126Duplicated collecting system (HP:0000081)1.88975345
127Renal cortical cysts (HP:0000803)1.88775882
128Cranial hyperostosis (HP:0004437)1.87601904
129Dyskinesia (HP:0100660)1.87467710
130Generalized hypopigmentation of hair (HP:0011358)1.87250977
131Agitation (HP:0000713)1.86276272
132Exotropia (HP:0000577)1.85968724
133Recurrent lower respiratory tract infections (HP:0002783)1.85549082
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.85126176
135Dialeptic seizures (HP:0011146)1.84619802
136Tubular atrophy (HP:0000092)1.84268797
137Decreased testicular size (HP:0008734)1.84033869
138Asplenia (HP:0001746)1.83349784
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.83320337
140Abnormal ciliary motility (HP:0012262)1.82076982
141Panhypogammaglobulinemia (HP:0003139)1.81964616
142Stomach cancer (HP:0012126)1.81379701
143Broad alveolar ridges (HP:0000187)1.81083428
144Aplasia/Hypoplasia of the tongue (HP:0010295)1.80761410
145Abnormality of the corticospinal tract (HP:0002492)1.80610804
146Occipital encephalocele (HP:0002085)1.80609191
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80445023
148T lymphocytopenia (HP:0005403)1.79420756
149Lymphoma (HP:0002665)1.78790447
150Attenuation of retinal blood vessels (HP:0007843)1.78757911
151Severe visual impairment (HP:0001141)1.78332229
152Congenital hepatic fibrosis (HP:0002612)1.78290514
153Renal Fanconi syndrome (HP:0001994)1.77720324
154Focal seizures (HP:0007359)1.77710069
155Abnormality of T cell number (HP:0011839)1.77304069
156Inability to walk (HP:0002540)1.76564093
157Hypothermia (HP:0002045)1.76169972
158Poor suck (HP:0002033)1.74584671
159Abnormality of chromosome stability (HP:0003220)1.74549594
160Methylmalonic acidemia (HP:0002912)1.74367593
161Oligodactyly (hands) (HP:0001180)1.74256114
162Optic disc pallor (HP:0000543)1.74236770
163Chronic sinusitis (HP:0011109)1.73825821
164Elevated erythrocyte sedimentation rate (HP:0003565)1.72893571
165Meningitis (HP:0001287)1.71953143
166Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71702147
167Degeneration of the lateral corticospinal tracts (HP:0002314)1.71702147
168Hypoplasia of the thymus (HP:0000778)1.70779769
169Retinitis pigmentosa (HP:0000510)1.70739971
170Morphological abnormality of the pyramidal tract (HP:0002062)1.70738990
171Hypoplasia of the brainstem (HP:0002365)1.69835884
172Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69835884
173Pancreatic fibrosis (HP:0100732)1.69592256
174Megalencephaly (HP:0001355)1.68590749
175Deformed sella turcica (HP:0002681)1.66024648
176Albinism (HP:0001022)1.65425944
177Pulmonary artery stenosis (HP:0004415)1.65321177
178Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.63759322
179Abnormality of DNA repair (HP:0003254)1.63555852
180Postaxial foot polydactyly (HP:0001830)1.62284074
181J-shaped sella turcica (HP:0002680)1.61309645
182Weak cry (HP:0001612)1.60382905
183Abnormal hair whorl (HP:0010721)1.59521640
184Impaired platelet aggregation (HP:0003540)1.59495924
185Abnormal platelet function (HP:0011869)1.59495924
186Autoimmune hemolytic anemia (HP:0001890)1.58589950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.59642300
2TRIM283.50845651
3MAP4K22.72443159
4STK162.55799790
5TNIK2.46281437
6STK38L2.42526696
7MAPKAPK52.38450791
8BMPR1B2.23652010
9TXK2.18431347
10MAP3K142.17223765
11INSRR2.11186196
12ERBB32.06292104
13SIK32.04967252
14DYRK21.83832164
15IRAK31.81139653
16CDK81.80902724
17MAP2K71.80220348
18TEC1.77857858
19CASK1.67860372
20PRPF4B1.63632733
21EPHB11.62792719
22IRAK11.60365811
23GRK71.57222660
24KIT1.55925552
25MKNK11.52634807
26CLK11.50190200
27NUAK11.48900725
28HIPK21.48580562
29FRK1.47296752
30BCR1.44760366
31CSNK1A1L1.44078719
32SRPK11.43355602
33IRAK41.41469522
34BTK1.39093926
35PINK11.38455927
36JAK31.33482174
37NEK91.32368884
38PLK21.31831865
39ZAK1.28492741
40BMPR21.27992730
41STK391.27922102
42PNCK1.20207591
43MAP3K131.19045914
44YES11.18434909
45EPHA31.17555692
46TLK11.17112717
47PAK31.14707472
48NEK61.10587178
49EPHA41.10481118
50STK101.09167285
51MAP2K41.08414483
52CDK91.06791627
53FLT31.06331732
54MAP4K11.06087994
55PRKCG1.05882486
56CSNK1G31.04452999
57WNK41.00228392
58DYRK30.98614421
59MAP3K60.97248513
60TGFBR10.97154254
61EIF2AK30.94082301
62IRAK20.93984807
63MAP2K30.93575320
64RPS6KA50.91911800
65IKBKB0.91341563
66VRK10.90856227
67SGK20.89172375
68CAMKK20.88357527
69DAPK20.85744930
70NTRK30.83485490
71CSNK1G10.82082566
72KSR10.81407732
73SYK0.81131450
74MAP2K60.81067159
75PASK0.80719577
76MAPK130.79605010
77TRPM70.78724781
78STK240.78656731
79CDK30.77313381
80LRRK20.76577637
81PRKCE0.76495319
82TAOK30.73963676
83PRKCQ0.73199867
84MUSK0.72831536
85DYRK1A0.71511885
86EIF2AK10.69958148
87MAP3K70.69462906
88CAMK2A0.69391900
89MAPK40.69059919
90PKN10.68587674
91LYN0.68114065
92CCNB10.67436842
93ITK0.67408373
94SGK4940.67369272
95SGK2230.67369272
96OBSCN0.64728268
97OXSR10.63975380
98DYRK1B0.63046261
99CSNK1G20.63016252
100LCK0.63002743
101RPS6KA40.62260980
102MAP3K100.62155496
103MAPK150.61819901
104STK40.61629646
105MINK10.61093034
106EIF2AK20.60014035
107ERBB20.59724106
108ADRBK20.58795018
109EPHB20.58482503
110MATK0.57483180
111UHMK10.57426948
112MKNK20.56712665
113PBK0.56051289
114MARK10.56039142
115PIK3CA0.55446123
116CAMK2B0.54313255
117CSF1R0.54054120
118CHUK0.53351310
119NLK0.53121983
120ACVR1B0.52822875
121CDK50.52393612
122FGFR20.50623718
123NTRK20.50536724
124GRK10.50044952
125PIM20.49580810
126BRD40.49268842
127PDK20.48641238
128ATR0.47205655
129BCKDK0.46651367
130NME10.46565777
131SIK20.46368647
132MAP3K120.45638669
133PRKACA0.45582843
134MAP3K50.45314438
135IKBKE0.44760063
136LIMK10.44687061
137TAOK10.44540292
138LATS10.43991336
139CDK140.43448958
140MAP3K90.43160652
141MAP3K40.41546624
142FER0.40710209
143DDR20.39587288
144CSNK1A10.38473875
145MOS0.38461293
146CAMK2G0.34314672
147MAPK70.33972743
148CDK180.31798911
149PHKG10.29794561
150PHKG20.29794561
151PRKACB0.28723468

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.04222203
2Nicotine addiction_Homo sapiens_hsa050333.53375496
3Oxidative phosphorylation_Homo sapiens_hsa001903.40393221
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.30907591
5Parkinsons disease_Homo sapiens_hsa050122.74473549
6Ether lipid metabolism_Homo sapiens_hsa005652.60007129
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.51871277
8DNA replication_Homo sapiens_hsa030302.51069583
9Fatty acid elongation_Homo sapiens_hsa000622.39401711
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.26907539
11Collecting duct acid secretion_Homo sapiens_hsa049662.24800199
12GABAergic synapse_Homo sapiens_hsa047272.11557405
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.10032737
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06617618
15Butanoate metabolism_Homo sapiens_hsa006502.05924281
16Sulfur metabolism_Homo sapiens_hsa009201.90756240
17Basal transcription factors_Homo sapiens_hsa030221.88980091
18Primary immunodeficiency_Homo sapiens_hsa053401.86567522
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80098234
20Taste transduction_Homo sapiens_hsa047421.77994460
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.76224117
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.75459310
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75368777
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75163062
25Cardiac muscle contraction_Homo sapiens_hsa042601.69722320
26Alzheimers disease_Homo sapiens_hsa050101.68922731
27Mismatch repair_Homo sapiens_hsa034301.68489560
28Regulation of autophagy_Homo sapiens_hsa041401.67551370
29Huntingtons disease_Homo sapiens_hsa050161.67001066
30Synaptic vesicle cycle_Homo sapiens_hsa047211.62145108
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60350146
32Morphine addiction_Homo sapiens_hsa050321.58399178
33Steroid biosynthesis_Homo sapiens_hsa001001.57016660
34Sphingolipid metabolism_Homo sapiens_hsa006001.56797574
35Glutamatergic synapse_Homo sapiens_hsa047241.54518783
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51478245
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51292770
38Non-homologous end-joining_Homo sapiens_hsa034501.50879460
39Base excision repair_Homo sapiens_hsa034101.47890830
40N-Glycan biosynthesis_Homo sapiens_hsa005101.46573599
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45216033
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.43903299
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43649501
44Cell cycle_Homo sapiens_hsa041101.42101323
45Circadian entrainment_Homo sapiens_hsa047131.41865683
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38270302
47Homologous recombination_Homo sapiens_hsa034401.37279015
48Dopaminergic synapse_Homo sapiens_hsa047281.36513800
49Allograft rejection_Homo sapiens_hsa053301.34223635
50Rheumatoid arthritis_Homo sapiens_hsa053231.33605185
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33334603
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29982808
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29530239
54Ribosome_Homo sapiens_hsa030101.29322140
55Circadian rhythm_Homo sapiens_hsa047101.25746136
56Basal cell carcinoma_Homo sapiens_hsa052171.25253168
57RNA degradation_Homo sapiens_hsa030181.25140671
58Linoleic acid metabolism_Homo sapiens_hsa005911.24896467
59Arachidonic acid metabolism_Homo sapiens_hsa005901.19009828
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18034171
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17784883
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17391959
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.16380358
64RNA polymerase_Homo sapiens_hsa030201.15943866
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15014389
66Olfactory transduction_Homo sapiens_hsa047401.13136563
67Propanoate metabolism_Homo sapiens_hsa006401.11821115
68Measles_Homo sapiens_hsa051621.11674445
69Cocaine addiction_Homo sapiens_hsa050301.09227246
70Hematopoietic cell lineage_Homo sapiens_hsa046401.02105500
71B cell receptor signaling pathway_Homo sapiens_hsa046620.98009180
72Amphetamine addiction_Homo sapiens_hsa050310.97742478
73Histidine metabolism_Homo sapiens_hsa003400.97659086
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96682630
75Autoimmune thyroid disease_Homo sapiens_hsa053200.95544595
76Notch signaling pathway_Homo sapiens_hsa043300.95390764
77Folate biosynthesis_Homo sapiens_hsa007900.93195285
78Leishmaniasis_Homo sapiens_hsa051400.89883157
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88726875
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85947725
81Nucleotide excision repair_Homo sapiens_hsa034200.83105256
82Pyrimidine metabolism_Homo sapiens_hsa002400.82267753
83Axon guidance_Homo sapiens_hsa043600.81903457
84Herpes simplex infection_Homo sapiens_hsa051680.80134563
85Fanconi anemia pathway_Homo sapiens_hsa034600.79550470
86Long-term depression_Homo sapiens_hsa047300.77578652
87Fatty acid metabolism_Homo sapiens_hsa012120.76079709
88Alcoholism_Homo sapiens_hsa050340.75888504
89Sulfur relay system_Homo sapiens_hsa041220.75535621
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74712341
91Tryptophan metabolism_Homo sapiens_hsa003800.74309994
92Insulin secretion_Homo sapiens_hsa049110.74213013
93Spliceosome_Homo sapiens_hsa030400.72744420
94p53 signaling pathway_Homo sapiens_hsa041150.72092377
95Hepatitis B_Homo sapiens_hsa051610.71269399
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70840676
97TNF signaling pathway_Homo sapiens_hsa046680.70273486
98T cell receptor signaling pathway_Homo sapiens_hsa046600.70184771
99Shigellosis_Homo sapiens_hsa051310.69927008
100Nitrogen metabolism_Homo sapiens_hsa009100.69435726
101Peroxisome_Homo sapiens_hsa041460.69063233
102Legionellosis_Homo sapiens_hsa051340.68354261
103Phototransduction_Homo sapiens_hsa047440.68067328
104Other glycan degradation_Homo sapiens_hsa005110.67042592
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64159901
106Platelet activation_Homo sapiens_hsa046110.64022705
107ABC transporters_Homo sapiens_hsa020100.63965735
108Serotonergic synapse_Homo sapiens_hsa047260.61222664
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60704196
110Hepatitis C_Homo sapiens_hsa051600.59970248
111Retinol metabolism_Homo sapiens_hsa008300.59700556
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59588356
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59241785
114Systemic lupus erythematosus_Homo sapiens_hsa053220.59052324
115Wnt signaling pathway_Homo sapiens_hsa043100.57910156
116Phagosome_Homo sapiens_hsa041450.56656413
117MicroRNAs in cancer_Homo sapiens_hsa052060.56341286
118Selenocompound metabolism_Homo sapiens_hsa004500.55925789
119Type II diabetes mellitus_Homo sapiens_hsa049300.55561408
120Cholinergic synapse_Homo sapiens_hsa047250.54399851
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52534808
122Pancreatic cancer_Homo sapiens_hsa052120.52390206
123Type I diabetes mellitus_Homo sapiens_hsa049400.52324631
124Pathways in cancer_Homo sapiens_hsa052000.52122969
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52104526
126Chronic myeloid leukemia_Homo sapiens_hsa052200.51956870
127Graft-versus-host disease_Homo sapiens_hsa053320.51382821
128mRNA surveillance pathway_Homo sapiens_hsa030150.50850638
129Oocyte meiosis_Homo sapiens_hsa041140.50746858
130Lysine degradation_Homo sapiens_hsa003100.50589946
131Chemokine signaling pathway_Homo sapiens_hsa040620.50277943
132Pertussis_Homo sapiens_hsa051330.49038192
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.48924491
134Small cell lung cancer_Homo sapiens_hsa052220.48302345
135Toxoplasmosis_Homo sapiens_hsa051450.47379151
136beta-Alanine metabolism_Homo sapiens_hsa004100.47318574
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47315585
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47022395
139Metabolic pathways_Homo sapiens_hsa011000.46606633
140Hedgehog signaling pathway_Homo sapiens_hsa043400.46575038
141HTLV-I infection_Homo sapiens_hsa051660.46523200
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45437781
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.43508565
144Osteoclast differentiation_Homo sapiens_hsa043800.43111635
145cAMP signaling pathway_Homo sapiens_hsa040240.42976441
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.41953092
147Apoptosis_Homo sapiens_hsa042100.39965366
148Ovarian steroidogenesis_Homo sapiens_hsa049130.39923170
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39821665
150Vitamin digestion and absorption_Homo sapiens_hsa049770.37518674
151Vibrio cholerae infection_Homo sapiens_hsa051100.37465087
152Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37230137
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35737032
154Salivary secretion_Homo sapiens_hsa049700.35261860
155Malaria_Homo sapiens_hsa051440.33256998
156Purine metabolism_Homo sapiens_hsa002300.32695144
157Asthma_Homo sapiens_hsa053100.30994346
158Proteasome_Homo sapiens_hsa030500.30142436
159Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28968062
160Salmonella infection_Homo sapiens_hsa051320.28831547
161Oxytocin signaling pathway_Homo sapiens_hsa049210.27978643
162Calcium signaling pathway_Homo sapiens_hsa040200.27271939
163Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25136790
164Fatty acid biosynthesis_Homo sapiens_hsa000610.24675669
165Ras signaling pathway_Homo sapiens_hsa040140.24176011
166Gap junction_Homo sapiens_hsa045400.22681392

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