THAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.21288746
2viral transcription (GO:0019083)7.09716220
3translational termination (GO:0006415)6.72781697
4ribosomal small subunit biogenesis (GO:0042274)6.65352528
5chaperone-mediated protein transport (GO:0072321)6.22089424
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.99065090
7cotranslational protein targeting to membrane (GO:0006613)5.91737525
8protein targeting to ER (GO:0045047)5.85293589
9translational elongation (GO:0006414)5.83834128
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.67675591
11protein localization to endoplasmic reticulum (GO:0070972)5.63262912
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.56578261
13establishment of protein localization to mitochondrial membrane (GO:0090151)5.52212086
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.33359350
15maturation of SSU-rRNA (GO:0030490)5.30603085
16viral life cycle (GO:0019058)5.27716089
17ATP synthesis coupled proton transport (GO:0015986)5.20779524
18energy coupled proton transport, down electrochemical gradient (GO:0015985)5.20779524
19regulation of mitochondrial translation (GO:0070129)5.11221565
20cellular protein complex disassembly (GO:0043624)5.01571303
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.97056482
22mitochondrial respiratory chain complex assembly (GO:0033108)4.92419164
23negative regulation of telomere maintenance (GO:0032205)4.90508269
24respiratory electron transport chain (GO:0022904)4.88319163
25electron transport chain (GO:0022900)4.80866115
26translational initiation (GO:0006413)4.67819177
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.58864189
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.58864189
29DNA damage response, detection of DNA damage (GO:0042769)4.55858503
30negative regulation of telomerase activity (GO:0051974)4.48708573
31protein-cofactor linkage (GO:0018065)4.47809480
32ribosomal large subunit biogenesis (GO:0042273)4.44173386
33positive regulation of gamma-delta T cell activation (GO:0046645)4.37106982
34protein complex disassembly (GO:0043241)4.26327108
35DNA deamination (GO:0045006)4.26023247
36negative regulation of erythrocyte differentiation (GO:0045647)4.25822266
37base-excision repair, AP site formation (GO:0006285)4.15380941
38protein targeting to mitochondrion (GO:0006626)4.09987477
39establishment of protein localization to mitochondrion (GO:0072655)3.99972015
40macromolecular complex disassembly (GO:0032984)3.96984409
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.91506210
42water-soluble vitamin biosynthetic process (GO:0042364)3.88410827
43antigen processing and presentation of endogenous antigen (GO:0019883)3.85597560
44protein targeting to membrane (GO:0006612)3.85457159
45translation (GO:0006412)3.81436914
46protein localization to mitochondrion (GO:0070585)3.74877599
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65184297
48antigen processing and presentation via MHC class Ib (GO:0002475)3.64879564
49response to interferon-beta (GO:0035456)3.64589766
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.57539908
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57155877
52metallo-sulfur cluster assembly (GO:0031163)3.49652184
53iron-sulfur cluster assembly (GO:0016226)3.49652184
54regulation of gamma-delta T cell differentiation (GO:0045586)3.46115207
55mRNA catabolic process (GO:0006402)3.45165630
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40618080
57DNA replication checkpoint (GO:0000076)3.39147169
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38700683
59respiratory chain complex IV assembly (GO:0008535)3.37471634
60peptidyl-histidine modification (GO:0018202)3.37112185
61regulation of telomerase activity (GO:0051972)3.34970019
62regulation of helicase activity (GO:0051095)3.33705812
63ribonucleoprotein complex biogenesis (GO:0022613)3.26641461
64positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25731052
65pyrimidine nucleotide catabolic process (GO:0006244)3.24954898
66purine nucleoside triphosphate biosynthetic process (GO:0009145)3.21584184
67purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.21248631
68ATP biosynthetic process (GO:0006754)3.21164736
69hydrogen ion transmembrane transport (GO:1902600)3.21082235
70L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20967093
71G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.20570017
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20517533
73protein neddylation (GO:0045116)3.20387239
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.20080859
75platelet dense granule organization (GO:0060155)3.14613352
76protein deneddylation (GO:0000338)3.13404345
77inner mitochondrial membrane organization (GO:0007007)3.11858763
78maturation of 5.8S rRNA (GO:0000460)3.10775258
79RNA catabolic process (GO:0006401)3.09896745
80proteasome assembly (GO:0043248)3.08858894
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.08675890
82tRNA methylation (GO:0030488)3.06647772
83spliceosomal snRNP assembly (GO:0000387)3.05326401
84negative regulation of ligase activity (GO:0051352)3.05116725
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05116725
86mitochondrial transport (GO:0006839)3.04694296
87cellular response to type I interferon (GO:0071357)3.03205457
88type I interferon signaling pathway (GO:0060337)3.03205457
89regulation of gamma-delta T cell activation (GO:0046643)3.02052002
90regulation of cellular amino acid metabolic process (GO:0006521)3.01991476
91negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.01375514
92response to type I interferon (GO:0034340)3.01145774
93cullin deneddylation (GO:0010388)2.99263919
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97385559
95intracellular protein transmembrane import (GO:0044743)2.96411694
96CTP biosynthetic process (GO:0006241)2.96107581
97CTP metabolic process (GO:0046036)2.96107581
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.95626088
99negative T cell selection (GO:0043383)2.95129904
100tRNA processing (GO:0008033)2.94223149
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94089324
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93821302
1037-methylguanosine mRNA capping (GO:0006370)2.93598521
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92875381
105cellular component biogenesis (GO:0044085)2.91143861
106proton transport (GO:0015992)2.90716618
107ATP hydrolysis coupled proton transport (GO:0015991)2.89738812
108energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.89738812
109regulation of B cell receptor signaling pathway (GO:0050855)2.89495403
110NIK/NF-kappaB signaling (GO:0038061)2.89141426
111GDP-mannose metabolic process (GO:0019673)2.87102912
112pseudouridine synthesis (GO:0001522)2.87065426
113positive regulation of lymphocyte apoptotic process (GO:0070230)2.85444716
114negative regulation of necroptotic process (GO:0060546)2.85391087
115negative regulation of glycoprotein biosynthetic process (GO:0010561)2.84462289
116interferon-gamma production (GO:0032609)2.84423688
117telomere maintenance via telomerase (GO:0007004)2.83820873
118RNA capping (GO:0036260)2.83459469
1197-methylguanosine RNA capping (GO:0009452)2.83459469
120transcription elongation from RNA polymerase III promoter (GO:0006385)2.83221258
121termination of RNA polymerase III transcription (GO:0006386)2.83221258
122positive regulation of ligase activity (GO:0051351)2.82821166
123hydrogen transport (GO:0006818)2.82209485
124formation of translation preinitiation complex (GO:0001731)2.81619272
125regulation of telomere maintenance via telomerase (GO:0032210)2.79671852
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78851981
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.78851981
128NADH dehydrogenase complex assembly (GO:0010257)2.78851981
129cytochrome complex assembly (GO:0017004)2.78714140
130protein complex biogenesis (GO:0070271)2.78618163
131regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78487553
132positive regulation of B cell differentiation (GO:0045579)2.78260783
133antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77410529
134negative thymic T cell selection (GO:0045060)2.77296912
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76120521
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76120521
137UTP biosynthetic process (GO:0006228)2.75847442
138pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75084183
139definitive hemopoiesis (GO:0060216)2.73268933
140establishment of protein localization to membrane (GO:0090150)2.72519754
141positive regulation of granulocyte differentiation (GO:0030854)2.71449663
142regulation of B cell differentiation (GO:0045577)2.71164590
143pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70660303
144rRNA modification (GO:0000154)2.67369906
145rRNA methylation (GO:0031167)2.66831009
146positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66550968
147pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.65416385
148regulation of regulatory T cell differentiation (GO:0045589)2.64043345
149B cell receptor signaling pathway (GO:0050853)2.62251714
150regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60549202
151quinone biosynthetic process (GO:1901663)2.57504348
152ubiquinone biosynthetic process (GO:0006744)2.57504348
153regulation of T cell mediated cytotoxicity (GO:0001914)2.56569828
154cellular response to interferon-beta (GO:0035458)2.56334944
155GTP biosynthetic process (GO:0006183)2.55496364
156lymphoid progenitor cell differentiation (GO:0002320)2.54450923
157tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53971292
158RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53971292
159antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.53878985
160mature B cell differentiation involved in immune response (GO:0002313)2.53678223
161guanosine-containing compound biosynthetic process (GO:1901070)2.52391071
162cellular response to interleukin-15 (GO:0071350)2.51341952
163oxidative phosphorylation (GO:0006119)2.50430093
164T cell homeostasis (GO:0043029)2.50161775
165DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49483112
166response to interferon-alpha (GO:0035455)2.49081766
167protein targeting (GO:0006605)2.47594942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human3.84159287
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.69547372
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.50749569
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.31152855
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.13757017
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08662545
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08476054
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.98896667
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98872867
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92986326
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84838551
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.81620986
13SCL_19346495_ChIP-Seq_HPC-7_Human2.76059211
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74242358
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.62384181
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.58359454
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.56479119
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.53048738
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46125263
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38641420
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32503692
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.30552201
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30121179
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27821729
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25374391
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.23316001
27VDR_23849224_ChIP-Seq_CD4+_Human2.15152275
28XRN2_22483619_ChIP-Seq_HELA_Human2.10248276
29FOXP3_21729870_ChIP-Seq_TREG_Human2.08103020
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.07553108
31MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04032500
32VDR_21846776_ChIP-Seq_THP-1_Human2.02561625
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02497333
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01225054
35MYC_22102868_ChIP-Seq_BL_Human1.96042241
36ERG_20887958_ChIP-Seq_HPC-7_Mouse1.95341451
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89656785
38CIITA_25753668_ChIP-Seq_RAJI_Human1.89216893
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84853768
40SPI1_23547873_ChIP-Seq_NB4_Human1.80344256
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77162556
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76849470
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76342615
44MAF_26560356_Chip-Seq_TH1_Human1.75427089
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67846525
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66977716
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66972845
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64025622
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63470824
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63020231
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61826812
52* MAF_26560356_Chip-Seq_TH2_Human1.55590986
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54040607
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53632830
55RUNX_20019798_ChIP-Seq_JUKART_Human1.53152831
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.52907507
57UTX_26944678_Chip-Seq_JUKART_Human1.48180355
58KDM5A_27292631_Chip-Seq_BREAST_Human1.45284340
59MYB_26560356_Chip-Seq_TH2_Human1.44513504
60GABP_19822575_ChIP-Seq_HepG2_Human1.44169665
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41604296
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38033046
63DCP1A_22483619_ChIP-Seq_HELA_Human1.36314242
64TTF2_22483619_ChIP-Seq_HELA_Human1.36191402
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35895331
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34386190
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33434609
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33326590
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32256101
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31882135
71* MYB_26560356_Chip-Seq_TH1_Human1.29429862
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29208963
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28418365
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.27081528
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.27034988
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.25913957
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.25840065
78VDR_24763502_ChIP-Seq_THP-1_Human1.25685098
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24906250
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24613975
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24377897
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23963298
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23234212
84GATA1_22025678_ChIP-Seq_K562_Human1.22483435
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21165912
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20055841
87* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19280017
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19147952
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18829933
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18354058
91* ELF1_20517297_ChIP-Seq_JURKAT_Human1.17471068
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17414737
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15281865
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14635089
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.14337272
96TP63_17297297_ChIP-ChIP_HaCaT_Human1.13992073
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12151842
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.11764889
99* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11694736
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11147835
101* P68_20966046_ChIP-Seq_HELA_Human1.09416999
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08958315
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08680906
104BCL6_27268052_Chip-Seq_Bcells_Human1.07694476
105ELK1_19687146_ChIP-ChIP_HELA_Human1.07152933
106* YY1_22570637_ChIP-Seq_MALME-3M_Human1.05950182
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05825754
108NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05644974
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04766211
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03780472
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03715149
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.03162078
113* BCOR_27268052_Chip-Seq_Bcells_Human1.02833619
114* PHF8_20622854_ChIP-Seq_HELA_Human1.01549099
115MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01292881
116E2F7_22180533_ChIP-Seq_HELA_Human1.01098803
117* E2F1_20622854_ChIP-Seq_HELA_Human1.00864103
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00419918
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00353053
120ZNF274_21170338_ChIP-Seq_K562_Hela0.99382113
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98339059
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98174152
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97039251
124* CTCF_20526341_ChIP-Seq_ESCs_Human0.96434408
125* SA1_27219007_Chip-Seq_Bcells_Human0.95433823
126* SA1_27219007_Chip-Seq_ERYTHROID_Human0.94170293
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93503424
128PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93114370
129GATA3_27048872_Chip-Seq_THYMUS_Human0.91615285
130ERA_21632823_ChIP-Seq_H3396_Human0.90416026
131STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90156677
132MYC_18940864_ChIP-ChIP_HL60_Human0.89997546
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89905649
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89626744
135* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89591641
136* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88061243
137CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87111341
138TFEB_21752829_ChIP-Seq_HELA_Human0.86253138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.05287277
2MP0009379_abnormal_foot_pigmentation3.96165097
3MP0005671_abnormal_response_to3.76032332
4MP0002396_abnormal_hematopoietic_system3.18388725
5MP0002132_abnormal_respiratory_system3.01918942
6MP0001835_abnormal_antigen_presentation2.81855862
7MP0000685_abnormal_immune_system2.74789832
8MP0003724_increased_susceptibility_to2.60786803
9MP0005075_abnormal_melanosome_morpholog2.54482384
10MP0009785_altered_susceptibility_to2.47713401
11MP0002277_abnormal_respiratory_mucosa2.46476817
12MP0002166_altered_tumor_susceptibility2.39664222
13MP0003786_premature_aging2.34549660
14MP0009333_abnormal_splenocyte_physiolog2.27426505
15MP0001529_abnormal_vocalization2.25130783
16MP0004381_abnormal_hair_follicle2.23566846
17MP0001800_abnormal_humoral_immune2.23346232
18MP0003693_abnormal_embryo_hatching2.21065574
19MP0006035_abnormal_mitochondrial_morpho2.20552970
20MP0005464_abnormal_platelet_physiology2.19744146
21MP0002420_abnormal_adaptive_immunity2.16520362
22MP0002723_abnormal_immune_serum2.15774491
23MP0002102_abnormal_ear_morphology2.13811386
24MP0002398_abnormal_bone_marrow2.10919546
25MP0001819_abnormal_immune_cell2.09903655
26MP0002837_dystrophic_cardiac_calcinosis2.03816855
27MP0001853_heart_inflammation2.03155505
28MP0005025_abnormal_response_to2.02150666
29MP0004808_abnormal_hematopoietic_stem1.99971447
30MP0002452_abnormal_antigen_presenting1.99513448
31MP0000465_gastrointestinal_hemorrhage1.96727006
32MP0005000_abnormal_immune_tolerance1.96149247
33MP0000716_abnormal_immune_system1.95948105
34MP0002722_abnormal_immune_system1.90265024
35MP0000689_abnormal_spleen_morphology1.89809300
36MP0000372_irregular_coat_pigmentation1.86535549
37MP0000703_abnormal_thymus_morphology1.82502955
38MP0001873_stomach_inflammation1.79171570
39MP0001188_hyperpigmentation1.78141801
40MP0008877_abnormal_DNA_methylation1.76403385
41MP0008995_early_reproductive_senescence1.74353901
42MP0002095_abnormal_skin_pigmentation1.71898829
43MP0005387_immune_system_phenotype1.71862280
44MP0001790_abnormal_immune_system1.71862280
45MP0002736_abnormal_nociception_after1.69884305
46MP0003866_abnormal_defecation1.68825047
47MP0002148_abnormal_hypersensitivity_rea1.68779326
48MP0002429_abnormal_blood_cell1.68298013
49MP0004133_heterotaxia1.67904661
50MP0003646_muscle_fatigue1.63889326
51MP0002405_respiratory_system_inflammati1.61475984
52MP0003111_abnormal_nucleus_morphology1.61265526
53MP0002006_tumorigenesis1.60870867
54MP0004142_abnormal_muscle_tone1.58963892
55MP0002653_abnormal_ependyma_morphology1.55466990
56MP0008004_abnormal_stomach_pH1.54454450
57MP0003880_abnormal_central_pattern1.53648946
58MP0010155_abnormal_intestine_physiology1.49150627
59MP0001919_abnormal_reproductive_system1.47724550
60MP0005174_abnormal_tail_pigmentation1.47215795
61MP0006082_CNS_inflammation1.46728073
62MP0002419_abnormal_innate_immunity1.46159276
63MP0002933_joint_inflammation1.43066039
64MP0000049_abnormal_middle_ear1.42108778
65MP0003136_yellow_coat_color1.41365461
66MP0001905_abnormal_dopamine_level1.41017434
67MP0002009_preneoplasia1.38579017
68MP0000343_altered_response_to1.37206125
69MP0006292_abnormal_olfactory_placode1.25943497
70MP0008875_abnormal_xenobiotic_pharmacok1.25384229
71MP0001764_abnormal_homeostasis1.24137590
72MP0003137_abnormal_impulse_conducting1.23850911
73MP0003191_abnormal_cellular_cholesterol1.23028855
74MP0005389_reproductive_system_phenotype1.22570748
75MP0009745_abnormal_behavioral_response1.20722305
76MP0010094_abnormal_chromosome_stability1.19879979
77MP0008469_abnormal_protein_level1.18444970
78MP0008932_abnormal_embryonic_tissue1.18055402
79MP0004947_skin_inflammation1.17222594
80MP0005646_abnormal_pituitary_gland1.15907866
81MP0001986_abnormal_taste_sensitivity1.15019628
82MP0003436_decreased_susceptibility_to1.14889007
83MP0004145_abnormal_muscle_electrophysio1.14536017
84MP0000490_abnormal_crypts_of1.14276601
85MP0009046_muscle_twitch1.12647550
86MP0001845_abnormal_inflammatory_respons1.12509350
87MP0000749_muscle_degeneration1.12397004
88MP0003787_abnormal_imprinting1.12307485
89MP0005058_abnormal_lysosome_morphology1.10938904
90MP0006276_abnormal_autonomic_nervous1.10132341
91MP0005397_hematopoietic_system_phenotyp1.09923368
92MP0001545_abnormal_hematopoietic_system1.09923368
93MP0001968_abnormal_touch/_nociception1.09156592
94MP0005367_renal/urinary_system_phenotyp1.07584075
95MP0000516_abnormal_urinary_system1.07584075
96MP0002160_abnormal_reproductive_system1.07406170
97MP0003315_abnormal_perineum_morphology1.06841164
98MP0003806_abnormal_nucleotide_metabolis1.05865738
99MP0006072_abnormal_retinal_apoptosis1.05825826
100MP0003828_pulmonary_edema1.04283546
101MP0008058_abnormal_DNA_repair1.02971330
102MP0005394_taste/olfaction_phenotype1.02838449
103MP0005499_abnormal_olfactory_system1.02838449
104MP0005409_darkened_coat_color1.02476070
105MP0005551_abnormal_eye_electrophysiolog1.01757900
106MP0000681_abnormal_thyroid_gland1.00749555
107MP0009384_cardiac_valve_regurgitation0.98971040
108MP0003941_abnormal_skin_development0.98533689
109MP0006036_abnormal_mitochondrial_physio0.97683019
110MP0005410_abnormal_fertilization0.97049087
111MP0003077_abnormal_cell_cycle0.96435519
112MP0003172_abnormal_lysosome_physiology0.96253832
113MP0003279_aneurysm0.94762563
114MP0003303_peritoneal_inflammation0.93344743
115MP0008007_abnormal_cellular_replicative0.92448819
116MP0000631_abnormal_neuroendocrine_gland0.91546761
117MP0002938_white_spotting0.91467016
118MP0002163_abnormal_gland_morphology0.91309729
119MP0001243_abnormal_dermal_layer0.90957814
120MP0001851_eye_inflammation0.90713471
121MP0005670_abnormal_white_adipose0.90596199
122MP0009764_decreased_sensitivity_to0.90376546
123MP0005266_abnormal_metabolism0.89854694
124MP0002254_reproductive_system_inflammat0.89417066
125MP0003195_calcinosis0.87802908
126MP0002064_seizures0.87791019
127MP0002210_abnormal_sex_determination0.87228548
128MP0010030_abnormal_orbit_morphology0.86738362
129MP0003938_abnormal_ear_development0.85068447
130MP0005451_abnormal_body_composition0.84856051
131MP0001970_abnormal_pain_threshold0.84299595
132MP0004510_myositis0.82834484
133MP0000358_abnormal_cell_content/0.81272720
134MP0005319_abnormal_enzyme/_coenzyme0.80303965
135MP0005023_abnormal_wound_healing0.80057622
136MP0004957_abnormal_blastocyst_morpholog0.80040267
137MP0001929_abnormal_gametogenesis0.79381038
138MP0005332_abnormal_amino_acid0.78795511
139MP0000858_altered_metastatic_potential0.78646764
140MP0003011_delayed_dark_adaptation0.77467801
141MP0001485_abnormal_pinna_reflex0.77035746
142MP0002019_abnormal_tumor_incidence0.76126387
143MP0002090_abnormal_vision0.75506299
144MP0000678_abnormal_parathyroid_gland0.73396980
145MP0003186_abnormal_redox_activity0.72458337
146MP0002249_abnormal_larynx_morphology0.72315337
147MP0000653_abnormal_sex_gland0.72271476
148MP0001145_abnormal_male_reproductive0.71651652
149MP0004147_increased_porphyrin_level0.71582396
150MP0002139_abnormal_hepatobiliary_system0.70828066
151MP0003943_abnormal_hepatobiliary_system0.70525709
152MP0009840_abnormal_foam_cell0.69419011
153MP0009765_abnormal_xenobiotic_induced0.69321351
154MP0005253_abnormal_eye_physiology0.68841950
155MP0002272_abnormal_nervous_system0.67948484
156MP0000747_muscle_weakness0.67591113
157MP0000313_abnormal_cell_death0.67102424
158MP0003698_abnormal_male_reproductive0.66616440
159MP0000015_abnormal_ear_pigmentation0.66433768
160MP0002876_abnormal_thyroid_physiology0.66151877
161MP0004036_abnormal_muscle_relaxation0.64697463
162MP0002060_abnormal_skin_morphology0.63946016
163MP0005084_abnormal_gallbladder_morpholo0.62970396
164MP0001216_abnormal_epidermal_layer0.59873719
165MP0003453_abnormal_keratinocyte_physiol0.59647700
166MP0001533_abnormal_skeleton_physiology0.58438266
167MP0009763_increased_sensitivity_to0.58336510
168MP0008789_abnormal_olfactory_epithelium0.58321930
169MP0004084_abnormal_cardiac_muscle0.57793951
170MP0002075_abnormal_coat/hair_pigmentati0.53605322

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.84247115
2Abnormality of cells of the erythroid lineage (HP:0012130)4.83589915
3Reticulocytopenia (HP:0001896)4.48042482
4Thrombocytosis (HP:0001894)4.09295991
5IgM deficiency (HP:0002850)3.86089467
6Elevated erythrocyte sedimentation rate (HP:0003565)3.70535562
7Cerebral edema (HP:0002181)3.62990806
8Hepatocellular necrosis (HP:0001404)3.51540133
9Macrocytic anemia (HP:0001972)3.46386908
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.23994617
11Type I transferrin isoform profile (HP:0003642)3.23930832
12Chronic otitis media (HP:0000389)3.22216843
13Petechiae (HP:0000967)3.20369253
14Hepatic necrosis (HP:0002605)3.17243007
15Mitochondrial inheritance (HP:0001427)3.16949227
16Aplastic anemia (HP:0001915)3.13290337
17Respiratory failure (HP:0002878)3.07774560
18Generalized aminoaciduria (HP:0002909)3.04718953
19Increased hepatocellular lipid droplets (HP:0006565)2.99051868
20Pallor (HP:0000980)2.93375151
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91497219
22Recurrent bronchitis (HP:0002837)2.87284534
23Methylmalonic aciduria (HP:0012120)2.86953162
24Increased serum pyruvate (HP:0003542)2.86814275
25Type 2 muscle fiber atrophy (HP:0003554)2.85775986
26Prolonged bleeding time (HP:0003010)2.79990166
27Muscle fiber atrophy (HP:0100295)2.76043116
28Increased CSF lactate (HP:0002490)2.74937914
29Respiratory difficulties (HP:0002880)2.72498508
30Centrally nucleated skeletal muscle fibers (HP:0003687)2.69184865
31Lipid accumulation in hepatocytes (HP:0006561)2.68321196
32Ragged-red muscle fibers (HP:0003200)2.67339109
33Optic disc pallor (HP:0000543)2.66855368
34Methylmalonic acidemia (HP:0002912)2.66731961
35Acute necrotizing encephalopathy (HP:0006965)2.59687352
36Nemaline bodies (HP:0003798)2.59399882
37Exertional dyspnea (HP:0002875)2.56782746
38Increased intramyocellular lipid droplets (HP:0012240)2.56192905
39IgG deficiency (HP:0004315)2.55033875
40Epistaxis (HP:0000421)2.53947620
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53058209
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53058209
43Renal Fanconi syndrome (HP:0001994)2.49151236
44Reduced subcutaneous adipose tissue (HP:0003758)2.47818379
45Progressive muscle weakness (HP:0003323)2.44394324
46Abnormality of the nasal mucosa (HP:0000433)2.43908453
47Panhypogammaglobulinemia (HP:0003139)2.43611532
48Nasal polyposis (HP:0100582)2.42316549
49T lymphocytopenia (HP:0005403)2.41758346
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41457351
51Emotional lability (HP:0000712)2.40793859
52Premature skin wrinkling (HP:0100678)2.39278131
53Abnormality of T cells (HP:0002843)2.39196540
54Chronic sinusitis (HP:0011109)2.38230388
55Muscle fiber inclusion bodies (HP:0100299)2.38081926
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37562607
57Abnormal protein N-linked glycosylation (HP:0012347)2.37562607
58Abnormal protein glycosylation (HP:0012346)2.37562607
59Abnormal glycosylation (HP:0012345)2.37562607
60CNS demyelination (HP:0007305)2.37194937
61Abnormality of glycolysis (HP:0004366)2.36907784
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.35770177
63Lethargy (HP:0001254)2.35036105
64Abnormal mitochondria in muscle tissue (HP:0008316)2.32791820
65Myositis (HP:0100614)2.31598051
66Microcytic anemia (HP:0001935)2.31576300
673-Methylglutaconic aciduria (HP:0003535)2.31166603
68Abnormality of urine glucose concentration (HP:0011016)2.30567616
69Glycosuria (HP:0003076)2.30567616
70Asplenia (HP:0001746)2.29722049
71Abnormality of renal resorption (HP:0011038)2.29719710
72Agammaglobulinemia (HP:0004432)2.27661006
73Abnormality of T cell number (HP:0011839)2.27352707
74Increased muscle lipid content (HP:0009058)2.27331843
75Cerebral hypomyelination (HP:0006808)2.27302676
76Purpura (HP:0000979)2.20238495
77Retinal dysplasia (HP:0007973)2.20011908
78Polyphagia (HP:0002591)2.19540008
79Lactic acidosis (HP:0003128)2.19205932
80Exercise intolerance (HP:0003546)2.19111565
81Nausea (HP:0002018)2.13965170
82Leukodystrophy (HP:0002415)2.13751024
83Broad face (HP:0000283)2.12265277
84Calcaneovalgus deformity (HP:0001848)2.11910033
85Parakeratosis (HP:0001036)2.11461810
86Hypothermia (HP:0002045)2.10359294
87Microvesicular hepatic steatosis (HP:0001414)2.09886192
88Hypoproteinemia (HP:0003075)2.09301089
89Increased serum lactate (HP:0002151)2.07375592
9011 pairs of ribs (HP:0000878)2.05584782
91Type II lissencephaly (HP:0007260)2.05389061
92Abnormality of the heme biosynthetic pathway (HP:0010472)2.05088840
93Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02636685
94Acute encephalopathy (HP:0006846)2.02424891
95Reduced antithrombin III activity (HP:0001976)2.01726129
96Deformed tarsal bones (HP:0008119)2.01208563
97Abnormal delayed hypersensitivity skin test (HP:0002963)2.01162943
98Aplasia/Hypoplasia of the spleen (HP:0010451)2.00783647
99Hyperalaninemia (HP:0003348)2.00688222
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00688222
101Abnormality of alanine metabolism (HP:0010916)2.00688222
102Weak cry (HP:0001612)2.00269021
103Impaired platelet aggregation (HP:0003540)1.98366930
104Abnormal platelet function (HP:0011869)1.98366930
105Abnormality of the labia minora (HP:0012880)1.97440631
106Seborrheic dermatitis (HP:0001051)1.96999903
107Abnormality of T cell physiology (HP:0011840)1.96342977
108Nonprogressive disorder (HP:0003680)1.93700200
109Hyperglycinemia (HP:0002154)1.93234063
110Lymphopenia (HP:0001888)1.92048164
111Pancytopenia (HP:0001876)1.90752126
112Microretrognathia (HP:0000308)1.90225113
113Progressive microcephaly (HP:0000253)1.89840393
114Severe combined immunodeficiency (HP:0004430)1.88460706
115Cerebral palsy (HP:0100021)1.87703752
116Chronic mucocutaneous candidiasis (HP:0002728)1.85168145
117Recurrent cutaneous fungal infections (HP:0011370)1.85168145
118Abnormality of eosinophils (HP:0001879)1.83991866
119Dry hair (HP:0011359)1.82782210
120Abnormality of glycolipid metabolism (HP:0010969)1.82156406
121Abnormality of liposaccharide metabolism (HP:0010968)1.82156406
122Abnormality of glycosphingolipid metabolism (HP:0004343)1.82156406
123X-linked dominant inheritance (HP:0001423)1.80925013
124Meningitis (HP:0001287)1.80898627
125Vomiting (HP:0002013)1.80859148
126Granulocytopenia (HP:0001913)1.79584510
127Absent thumb (HP:0009777)1.79461386
128Dicarboxylic aciduria (HP:0003215)1.78401681
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78401681
130Abnormality of cells of the lymphoid lineage (HP:0012140)1.77094481
131Pustule (HP:0200039)1.76992653
132Thyroid-stimulating hormone excess (HP:0002925)1.76418961
133Hepatosplenomegaly (HP:0001433)1.76218830
134Encephalitis (HP:0002383)1.75718931
135Progressive macrocephaly (HP:0004481)1.75475140
136Squamous cell carcinoma (HP:0002860)1.73357896
137Amblyopia (HP:0000646)1.73020759
138Medial flaring of the eyebrow (HP:0010747)1.72846940
139Paralysis (HP:0003470)1.71834633
140Anencephaly (HP:0002323)1.69525953
141Gliosis (HP:0002171)1.67770323
142Colon cancer (HP:0003003)1.67535106
143Blindness (HP:0000618)1.65484847
144Sclerocornea (HP:0000647)1.65072020
145Abnormality of lateral ventricle (HP:0030047)1.64294456
146Esophageal atresia (HP:0002032)1.63170544
147Hypoplastic pelvis (HP:0008839)1.62794674
148Abnormality of the anterior horn cell (HP:0006802)1.62465125
149Degeneration of anterior horn cells (HP:0002398)1.62465125
150Amniotic constriction ring (HP:0009775)1.62283134
151Abnormality of placental membranes (HP:0011409)1.62283134
152Opisthotonus (HP:0002179)1.61572902
153CNS hypomyelination (HP:0003429)1.61010476
154Neutropenia (HP:0001875)1.58438806
155Hyperphosphaturia (HP:0003109)1.57666640
156Myokymia (HP:0002411)1.57663788
157Hypoplasia of the pons (HP:0012110)1.57185231
158Mutism (HP:0002300)1.55275505
159Redundant skin (HP:0001582)1.54858983
160Cortical visual impairment (HP:0100704)1.53200901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK25.41485824
2MAP4K14.48910661
3TNIK3.71962880
4MAPK153.24197828
5TXK2.92654333
6NME22.92627032
7VRK22.91759801
8STK162.91098753
9TGFBR22.28865421
10GRK72.25891528
11MAP4K21.96524162
12MUSK1.95743632
13MAP3K51.95174295
14PLK41.88677686
15ZAP701.88417559
16BCKDK1.85715610
17NLK1.83279683
18BTK1.77313072
19JAK31.75288591
20MAP2K71.70161991
21PIM21.65877696
22KIT1.63881903
23DYRK21.63700598
24NUAK11.63311502
25IKBKE1.63024907
26TEC1.60800671
27MAP2K61.57873666
28TYK21.49645749
29ITK1.47899379
30EEF2K1.45537102
31SIK21.45166889
32NEK11.45035786
33RPS6KB21.38917387
34STK101.35234916
35CDC71.33250667
36TBK11.32888429
37ACVR1B1.32693911
38BLK1.31507705
39MAP2K31.28796539
40KDR1.28462654
41MYLK1.27835249
42IKBKB1.27211402
43TGFBR11.26286133
44CSNK1G21.21080646
45NME11.19391912
46SYK1.18185096
47LCK1.17471858
48ABL21.15766933
49MAP3K121.15545038
50LRRK21.13068264
51IRAK41.12990079
52FGFR41.12055329
53CSF1R1.10505775
54CDK191.08577666
55BUB11.08541978
56TRIM281.08477667
57CDK81.08048757
58WNK31.06513947
59AURKA1.04566830
60PASK1.04377396
61ADRBK21.02738680
62MARK31.01288131
63TSSK61.01181691
64CSNK1A1L0.99116828
65DAPK30.95502580
66MAP2K20.95062479
67CLK10.94472846
68MAPKAPK50.93748004
69IRAK30.93721725
70IRAK10.93513224
71VRK10.91994790
72PBK0.89623420
73WEE10.89183707
74PLK10.89169762
75MAPKAPK30.88929657
76PDK20.88728390
77TESK20.88564012
78TNK20.87829239
79OBSCN0.87603304
80MOS0.87508103
81TLK10.82892369
82ATR0.82209541
83CDK30.81740731
84MAPK70.81693456
85MAP3K110.80481991
86FLT30.78927709
87PIK3CG0.78141133
88EIF2AK30.77794583
89TAF10.73492207
90TIE10.71904517
91RPS6KA50.71352831
92CCNB10.69528335
93MAPKAPK20.69388588
94MAPK40.69280794
95MAP3K70.67015882
96OXSR10.66982922
97LYN0.66870157
98CDK140.66848108
99MAPK110.66660405
100CAMK10.66602335
101HCK0.66597004
102PKN10.65619530
103DAPK10.64515291
104RPS6KA40.64169277
105TRPM70.63778391
106ILK0.63013543
107PINK10.62688344
108CSNK2A10.62513947
109CHEK20.62146369
110MAPK130.60763876
111MAPK120.60581845
112PRKD30.60494522
113PLK30.58645442
114CDK11A0.56617391
115ERN10.56590034
116BRAF0.56570126
117MKNK10.55173689
118PHKG10.54914182
119PHKG20.54914182
120BRSK10.54539992
121FES0.54039135
122CDK150.53468601
123EPHA30.53378451
124GRK10.52200160
125RPS6KA60.51508302
126SRPK10.51315731
127CDK180.50502665
128PRKCG0.50116310
129PAK10.50070905
130MAP3K80.49322623
131LIMK10.48958613
132DYRK30.48893615
133CSK0.48486097
134JAK10.48053876
135MARK10.47651828
136CSNK1G30.47129466
137PRKD20.46975383
138AURKB0.46655184
139HIPK20.46568600
140DAPK20.46343831
141PAK60.45252497
142YES10.45130164
143CDK70.43727848
144STK40.43115756
145CSNK1G10.42034801
146ZAK0.41636113
147CSNK2A20.41282821
148GRK50.40862743
149MST40.39976980
150EIF2AK20.39621981
151PRKCQ0.39545770
152RPS6KL10.39531393
153RPS6KC10.39531393
154ARAF0.39502457
155EPHB20.39302256
156TESK10.36947485
157INSRR0.36811402
158MAP3K40.36598966
159CSNK1A10.35964226
160GRK60.34851376
161TTK0.33434234
162MAP2K40.32582915
163MAP3K90.31428289
164PIM10.31273899
165TAOK30.30252472

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.54710107
2Primary immunodeficiency_Homo sapiens_hsa053403.46691994
3Proteasome_Homo sapiens_hsa030503.17153191
4RNA polymerase_Homo sapiens_hsa030202.46202384
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.45233975
6DNA replication_Homo sapiens_hsa030302.45131041
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.40237197
8Protein export_Homo sapiens_hsa030602.25709716
9Base excision repair_Homo sapiens_hsa034102.23493318
10Pyrimidine metabolism_Homo sapiens_hsa002402.05003856
11Mismatch repair_Homo sapiens_hsa034302.04609641
12Sulfur relay system_Homo sapiens_hsa041222.04326381
13Oxidative phosphorylation_Homo sapiens_hsa001901.92817498
14Nucleotide excision repair_Homo sapiens_hsa034201.90167441
15Parkinsons disease_Homo sapiens_hsa050121.83325648
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81520407
17Collecting duct acid secretion_Homo sapiens_hsa049661.76257538
18Cardiac muscle contraction_Homo sapiens_hsa042601.72830504
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69225002
20Homologous recombination_Homo sapiens_hsa034401.68306087
21Spliceosome_Homo sapiens_hsa030401.68077194
22Fatty acid elongation_Homo sapiens_hsa000621.49145090
23Other glycan degradation_Homo sapiens_hsa005111.44035732
24Measles_Homo sapiens_hsa051621.39898662
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32749014
26Antigen processing and presentation_Homo sapiens_hsa046121.30563514
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.28190774
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23739213
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22016808
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21938779
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20419642
32Non-homologous end-joining_Homo sapiens_hsa034501.19254142
33Alzheimers disease_Homo sapiens_hsa050101.17896465
34Rheumatoid arthritis_Homo sapiens_hsa053231.16850237
35Leishmaniasis_Homo sapiens_hsa051401.15898343
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15518222
37Steroid biosynthesis_Homo sapiens_hsa001001.15063148
38Purine metabolism_Homo sapiens_hsa002301.13068746
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11888083
40RNA degradation_Homo sapiens_hsa030181.11620516
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08994649
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08679291
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.07813433
44Hematopoietic cell lineage_Homo sapiens_hsa046401.07572006
45Huntingtons disease_Homo sapiens_hsa050161.06487148
46B cell receptor signaling pathway_Homo sapiens_hsa046621.03685839
47Herpes simplex infection_Homo sapiens_hsa051681.02598479
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00101842
49Sulfur metabolism_Homo sapiens_hsa009200.98790141
50Basal transcription factors_Homo sapiens_hsa030220.96886148
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96655761
52T cell receptor signaling pathway_Homo sapiens_hsa046600.96229015
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.95480431
54Chemical carcinogenesis_Homo sapiens_hsa052040.93228520
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92877190
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.91530158
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89924321
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.88923073
59Pentose phosphate pathway_Homo sapiens_hsa000300.88512518
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87826057
61Folate biosynthesis_Homo sapiens_hsa007900.87791700
62Pyruvate metabolism_Homo sapiens_hsa006200.86451895
63Selenocompound metabolism_Homo sapiens_hsa004500.86154272
64Glutathione metabolism_Homo sapiens_hsa004800.85014816
65Phototransduction_Homo sapiens_hsa047440.84849778
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82104178
67One carbon pool by folate_Homo sapiens_hsa006700.80883443
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79736804
69Galactose metabolism_Homo sapiens_hsa000520.79478994
70Fructose and mannose metabolism_Homo sapiens_hsa000510.79194883
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76998150
72Synaptic vesicle cycle_Homo sapiens_hsa047210.76686389
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76667180
74Epstein-Barr virus infection_Homo sapiens_hsa051690.73625009
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72204263
76Lysosome_Homo sapiens_hsa041420.69586541
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66596962
78p53 signaling pathway_Homo sapiens_hsa041150.65891391
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.64156371
80Regulation of autophagy_Homo sapiens_hsa041400.63262288
81RNA transport_Homo sapiens_hsa030130.62812110
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61927707
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61534952
84Notch signaling pathway_Homo sapiens_hsa043300.61183228
85Vibrio cholerae infection_Homo sapiens_hsa051100.60343423
86Butanoate metabolism_Homo sapiens_hsa006500.59900130
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59121629
88N-Glycan biosynthesis_Homo sapiens_hsa005100.58737409
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58691225
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57870091
91Caffeine metabolism_Homo sapiens_hsa002320.56668837
92Arachidonic acid metabolism_Homo sapiens_hsa005900.56443276
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.55757644
94Metabolic pathways_Homo sapiens_hsa011000.55671224
95Autoimmune thyroid disease_Homo sapiens_hsa053200.55492377
96Fanconi anemia pathway_Homo sapiens_hsa034600.55107298
97Acute myeloid leukemia_Homo sapiens_hsa052210.55102967
98Platelet activation_Homo sapiens_hsa046110.54945989
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54845682
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.53949037
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53586993
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53584632
103Osteoclast differentiation_Homo sapiens_hsa043800.49300436
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47812150
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47637341
106Biosynthesis of amino acids_Homo sapiens_hsa012300.46531125
107Shigellosis_Homo sapiens_hsa051310.46361998
108Vitamin B6 metabolism_Homo sapiens_hsa007500.45769619
109Allograft rejection_Homo sapiens_hsa053300.45668820
110Carbon metabolism_Homo sapiens_hsa012000.45349208
111Tryptophan metabolism_Homo sapiens_hsa003800.44092461
112Salmonella infection_Homo sapiens_hsa051320.42563122
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40100039
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40041660
115Systemic lupus erythematosus_Homo sapiens_hsa053220.39110717
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39090976
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.38119471
118HTLV-I infection_Homo sapiens_hsa051660.37468284
119Hepatitis B_Homo sapiens_hsa051610.37134229
120Apoptosis_Homo sapiens_hsa042100.36797517
121Pertussis_Homo sapiens_hsa051330.36569864
122Retinol metabolism_Homo sapiens_hsa008300.35070097
123Nicotine addiction_Homo sapiens_hsa050330.33832936
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33598171
125Asthma_Homo sapiens_hsa053100.33070045
126Cell cycle_Homo sapiens_hsa041100.32835802
127Graft-versus-host disease_Homo sapiens_hsa053320.31676135
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31470765
129Hepatitis C_Homo sapiens_hsa051600.30431399
130Tyrosine metabolism_Homo sapiens_hsa003500.29817243
131Influenza A_Homo sapiens_hsa051640.27229123
132Legionellosis_Homo sapiens_hsa051340.26230688
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25798421
134Vitamin digestion and absorption_Homo sapiens_hsa049770.25668863
135Propanoate metabolism_Homo sapiens_hsa006400.25359570
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25339207
137Histidine metabolism_Homo sapiens_hsa003400.23247884
138Peroxisome_Homo sapiens_hsa041460.23028865
139beta-Alanine metabolism_Homo sapiens_hsa004100.20185470
140Phenylalanine metabolism_Homo sapiens_hsa003600.18140687

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