ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	4.63551623
2	cellular ketone body metabolic process (GO:0046950)	4.16945260
3	regulation of hexokinase activity (GO:1903299)	4.13592774
4	regulation of glucokinase activity (GO:0033131)	4.13592774
5	DNA deamination (GO:0045006)	4.03344234
6	ketone body metabolic process (GO:1902224)	3.96773265
7	behavioral response to nicotine (GO:0035095)	3.86579439
8	respiratory chain complex IV assembly (GO:0008535)	3.84621953
9	response to pheromone (GO:0019236)	3.77270430
10	platelet dense granule organization (GO:0060155)	3.76245733
11	inositol phosphate catabolic process (GO:0071545)	3.69000075
12	lactate metabolic process (GO:0006089)	3.46577533
13	cytochrome complex assembly (GO:0017004)	3.42293245
14	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.30797223
15	inositol phosphate dephosphorylation (GO:0046855)	3.30797223
16	protein complex biogenesis (GO:0070271)	3.27620485
17	L-fucose catabolic process (GO:0042355)	3.20571462
18	fucose catabolic process (GO:0019317)	3.20571462
19	L-fucose metabolic process (GO:0042354)	3.20571462
20	kidney morphogenesis (GO:0060993)	3.15703718
21	signal peptide processing (GO:0006465)	3.11472037
22	polyol catabolic process (GO:0046174)	3.07834776
23	prostate gland growth (GO:0060736)	3.02344996
24	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99603157
25	S-adenosylmethionine metabolic process (GO:0046500)	2.94525435
26	protein K6-linked ubiquitination (GO:0085020)	2.93674125
27	axoneme assembly (GO:0035082)	2.90114804
28	positive regulation of glycolytic process (GO:0045821)	2.88784883
29	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.88725140
30	preassembly of GPI anchor in ER membrane (GO:0016254)	2.88101773
31	protein K11-linked deubiquitination (GO:0035871)	2.85759980
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.80843135
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.80843135
34	NADH dehydrogenase complex assembly (GO:0010257)	2.80843135
35	protein localization to cilium (GO:0061512)	2.77663328
36	negative regulation of membrane potential (GO:0045837)	2.77574709
37	regulation of neurotransmitter uptake (GO:0051580)	2.77443545
38	mannosylation (GO:0097502)	2.77313867
39	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76629399
40	negative regulation of neurological system process (GO:0031645)	2.75987355
41	dentate gyrus development (GO:0021542)	2.75863977
42	positive regulation of meiosis (GO:0045836)	2.73516434
43	endocrine pancreas development (GO:0031018)	2.72047577
44	positive regulation of protein autophosphorylation (GO:0031954)	2.69247789
45	parental behavior (GO:0060746)	2.68749056
46	indolalkylamine metabolic process (GO:0006586)	2.68695149
47	tryptophan catabolic process (GO:0006569)	2.67756750
48	indole-containing compound catabolic process (GO:0042436)	2.67756750
49	indolalkylamine catabolic process (GO:0046218)	2.67756750
50	DNA double-strand break processing (GO:0000729)	2.67250698
51	gamma-aminobutyric acid transport (GO:0015812)	2.66491058
52	keratinocyte development (GO:0003334)	2.66234162
53	protein polyglutamylation (GO:0018095)	2.65024799
54	presynaptic membrane assembly (GO:0097105)	2.63654949
55	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.62757167
56	adaptation of signaling pathway (GO:0023058)	2.62566825
57	negative regulation of protein oligomerization (GO:0032460)	2.59669829
58	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.59182034
59	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.58646526
60	dendritic spine morphogenesis (GO:0060997)	2.56916462
61	anterograde synaptic vesicle transport (GO:0048490)	2.56747477
62	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.55596022
63	regulation of meiosis I (GO:0060631)	2.55042655
64	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.54941829
65	branched-chain amino acid catabolic process (GO:0009083)	2.54069629
66	positive regulation of meiotic cell cycle (GO:0051446)	2.52737781
67	maturation of 5.8S rRNA (GO:0000460)	2.52279421
68	kynurenine metabolic process (GO:0070189)	2.52041861
69	synapsis (GO:0007129)	2.51350055
70	nitric oxide mediated signal transduction (GO:0007263)	2.50378820
71	cilium morphogenesis (GO:0060271)	2.49877756
72	reflex (GO:0060004)	2.48705853
73	negative regulation of acute inflammatory response (GO:0002674)	2.47644923
74	magnesium ion transport (GO:0015693)	2.47371187
75	protein prenylation (GO:0018342)	2.46527727
76	prenylation (GO:0097354)	2.46527727
77	GPI anchor metabolic process (GO:0006505)	2.44652574
78	insulin secretion (GO:0030073)	2.44649674
79	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.44476968
80	piRNA metabolic process (GO:0034587)	2.42806329
81	protein-cofactor linkage (GO:0018065)	2.42367642
82	dopamine transport (GO:0015872)	2.42097554
83	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.41421690
84	intraciliary transport (GO:0042073)	2.40680494
85	cullin deneddylation (GO:0010388)	2.40353832
86	nonmotile primary cilium assembly (GO:0035058)	2.39856940
87	proteasome assembly (GO:0043248)	2.39569751
88	detection of light stimulus involved in visual perception (GO:0050908)	2.39489140
89	detection of light stimulus involved in sensory perception (GO:0050962)	2.39489140
90	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.39035589
91	cornea development in camera-type eye (GO:0061303)	2.38509464
92	presynaptic membrane organization (GO:0097090)	2.38477981
93	epithelial cilium movement (GO:0003351)	2.36932495
94	neuron fate determination (GO:0048664)	2.35940699
95	neural tube formation (GO:0001841)	2.35924747
96	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.35796907
97	C-terminal protein lipidation (GO:0006501)	2.35759138
98	protein deneddylation (GO:0000338)	2.35185341
99	peptidyl-histidine modification (GO:0018202)	2.34561233
100	photoreceptor cell maintenance (GO:0045494)	2.34346834

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.91500674
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11563853
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.90177123
4	VDR_22108803_ChIP-Seq_LS180_Human	2.79818630
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.79163517
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.57128493
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50177068
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.26852323
9	EWS_26573619_Chip-Seq_HEK293_Human	2.24712293
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18757617
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.18357950
12	FUS_26573619_Chip-Seq_HEK293_Human	2.18137536
13	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09093383
14	P300_19829295_ChIP-Seq_ESCs_Human	2.07203069
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.05797787
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.03172025
17	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.02698731
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02061552
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.00105314
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.95852375
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91985725
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88259579
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.83532096
24	* ER_23166858_ChIP-Seq_MCF-7_Human	1.72529457
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.67013604
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66111571
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65327981
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64837951
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.64088324
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.60055670
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57288987
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55957461
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55499502
34	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.55256715
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.54339841
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.54231595
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54231595
38	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.52616368
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51047082
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50538627
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50460403
42	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47162014
43	AR_25329375_ChIP-Seq_VCAP_Human	1.45984675
44	STAT3_23295773_ChIP-Seq_U87_Human	1.44462234
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.43813282
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42084811
47	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42027619
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40815761
49	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39120860
50	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.36925540
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35426579
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34704582
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34704582
54	VDR_23849224_ChIP-Seq_CD4+_Human	1.34123830
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.33390532
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33357045
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33342093
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.32019920
59	P53_22387025_ChIP-Seq_ESCs_Mouse	1.31748917
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31697205
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.31591535
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31157537
63	TCF4_23295773_ChIP-Seq_U87_Human	1.30082754
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28916205
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28916205
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28166064
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.26373622
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25852636
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.22807461
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22444281
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21903876
72	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21728904
73	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21155966
74	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.19535038
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19403053
76	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18371734
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18354222
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16222202
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.15813576
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14139871
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13220551
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.13114907
83	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.12356820
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12315515
85	P300_18555785_Chip-Seq_ESCs_Mouse	1.11941151
86	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.11783791
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10948347
88	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09048423
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08643156
90	AR_20517297_ChIP-Seq_VCAP_Human	1.08154322
91	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.07848385
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07555783
93	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07496246
94	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.07451514
95	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06723292
96	NCOR_22424771_ChIP-Seq_293T_Human	1.05338990
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05302864
98	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.04973305
99	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.04803665
100	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02528595

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.83091472
2	MP0003195_calcinosis	3.29286719
3	MP0003787_abnormal_imprinting	2.97929518
4	MP0008877_abnormal_DNA_methylation	2.94592736
5	MP0002102_abnormal_ear_morphology	2.61433819
6	MP0005646_abnormal_pituitary_gland	2.51049552
7	MP0006072_abnormal_retinal_apoptosis	2.49267465
8	MP0002163_abnormal_gland_morphology	2.47644780
9	MP0005379_endocrine/exocrine_gland_phen	2.41031567
10	MP0000372_irregular_coat_pigmentation	2.14802364
11	MP0005645_abnormal_hypothalamus_physiol	2.09671867
12	MP0005551_abnormal_eye_electrophysiolog	2.09487867
13	MP0002876_abnormal_thyroid_physiology	2.08941154
14	MP0009046_muscle_twitch	2.02456453
15	MP0001984_abnormal_olfaction	1.89967513
16	MP0005253_abnormal_eye_physiology	1.85507535
17	MP0003646_muscle_fatigue	1.79930274
18	MP0003122_maternal_imprinting	1.72794712
19	MP0009745_abnormal_behavioral_response	1.72141356
20	MP0002638_abnormal_pupillary_reflex	1.71531585
21	MP0009780_abnormal_chondrocyte_physiolo	1.66243985
22	MP0002938_white_spotting	1.60597209
23	MP0000569_abnormal_digit_pigmentation	1.57027692
24	MP0001986_abnormal_taste_sensitivity	1.54948376
25	MP0000631_abnormal_neuroendocrine_gland	1.54914913
26	MP0002160_abnormal_reproductive_system	1.54767683
27	MP0003121_genomic_imprinting	1.54658820
28	MP0000427_abnormal_hair_cycle	1.53591468
29	MP0002909_abnormal_adrenal_gland	1.52125755
30	MP0006292_abnormal_olfactory_placode	1.51602394
31	MP0002272_abnormal_nervous_system	1.48298283
32	MP0004885_abnormal_endolymph	1.48039739
33	MP0005174_abnormal_tail_pigmentation	1.47687983
34	MP0010234_abnormal_vibrissa_follicle	1.44602882
35	MP0004142_abnormal_muscle_tone	1.43963957
36	MP0001968_abnormal_touch/_nociception	1.42851390
37	MP0005389_reproductive_system_phenotype	1.42343128
38	MP0001944_abnormal_pancreas_morphology	1.40358986
39	MP0005075_abnormal_melanosome_morpholog	1.39840950
40	MP0002693_abnormal_pancreas_physiology	1.35466658
41	MP0008872_abnormal_physiological_respon	1.34330536
42	MP0003880_abnormal_central_pattern	1.33878837
43	MP0005084_abnormal_gallbladder_morpholo	1.29153132
44	MP0002234_abnormal_pharynx_morphology	1.27327645
45	MP0003011_delayed_dark_adaptation	1.26234077
46	MP0002557_abnormal_social/conspecific_i	1.21702611
47	MP0004215_abnormal_myocardial_fiber	1.21048131
48	MP0004924_abnormal_behavior	1.20485100
49	MP0005386_behavior/neurological_phenoty	1.20485100
50	MP0002928_abnormal_bile_duct	1.18749595
51	MP0003283_abnormal_digestive_organ	1.18435552
52	MP0001485_abnormal_pinna_reflex	1.17550779
53	MP0005220_abnormal_exocrine_pancreas	1.16036785
54	MP0004133_heterotaxia	1.15921465
55	MP0005367_renal/urinary_system_phenotyp	1.14024586
56	MP0000516_abnormal_urinary_system	1.14024586
57	MP0001501_abnormal_sleep_pattern	1.14003610
58	MP0002736_abnormal_nociception_after	1.12600037
59	MP0002064_seizures	1.12187807
60	MP0008058_abnormal_DNA_repair	1.11370238
61	MP0005332_abnormal_amino_acid	1.11132358
62	MP0004043_abnormal_pH_regulation	1.10844378
63	MP0001486_abnormal_startle_reflex	1.08739873
64	MP0006036_abnormal_mitochondrial_physio	1.06314856
65	MP0001905_abnormal_dopamine_level	1.06149680
66	MP0001919_abnormal_reproductive_system	1.05582121
67	MP0001529_abnormal_vocalization	1.05016223
68	MP0004147_increased_porphyrin_level	1.04738375
69	MP0002572_abnormal_emotion/affect_behav	1.04612128
70	MP0006276_abnormal_autonomic_nervous	1.00909907
71	MP0002090_abnormal_vision	1.00325759
72	MP0002277_abnormal_respiratory_mucosa	0.99869003
73	MP0008775_abnormal_heart_ventricle	0.98197610
74	MP0003786_premature_aging	0.97119701
75	MP0000613_abnormal_salivary_gland	0.95316711
76	MP0003137_abnormal_impulse_conducting	0.92738417
77	MP0001764_abnormal_homeostasis	0.92483554
78	MP0010386_abnormal_urinary_bladder	0.92107774
79	MP0000639_abnormal_adrenal_gland	0.91494855
80	MP0008875_abnormal_xenobiotic_pharmacok	0.91002845
81	MP0008995_early_reproductive_senescence	0.90735125
82	MP0001970_abnormal_pain_threshold	0.88673232
83	MP0004145_abnormal_muscle_electrophysio	0.88404385
84	MP0002095_abnormal_skin_pigmentation	0.88132195
85	MP0003718_maternal_effect	0.86832452
86	MP0000647_abnormal_sebaceous_gland	0.86766436
87	MP0002751_abnormal_autonomic_nervous	0.86331091
88	MP0010678_abnormal_skin_adnexa	0.85652896
89	MP0002734_abnormal_mechanical_nocicepti	0.85631391
90	MP0001661_extended_life_span	0.84712519
91	MP0002229_neurodegeneration	0.83876119
92	MP0000013_abnormal_adipose_tissue	0.83232240
93	MP0010329_abnormal_lipoprotein_level	0.82791384
94	MP0001756_abnormal_urination	0.82432772
95	MP0001440_abnormal_grooming_behavior	0.82349644
96	MP0005187_abnormal_penis_morphology	0.82307412
97	MP0005195_abnormal_posterior_eye	0.81643987
98	MP0000015_abnormal_ear_pigmentation	0.80883640
99	MP0001929_abnormal_gametogenesis	0.79394866
100	MP0002078_abnormal_glucose_homeostasis	0.79095880

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.57126048
2	Hypothermia (HP:0002045)	3.48108423
3	Pancreatic fibrosis (HP:0100732)	3.44102031
4	Abnormality of midbrain morphology (HP:0002418)	3.25941959
5	Molar tooth sign on MRI (HP:0002419)	3.25941959
6	Nephronophthisis (HP:0000090)	3.20091608
7	Neoplasm of the adrenal cortex (HP:0100641)	3.12250032
8	Congenital stationary night blindness (HP:0007642)	3.11073088
9	Abnormality of the renal cortex (HP:0011035)	3.10570931
10	Medial flaring of the eyebrow (HP:0010747)	3.10221980
11	True hermaphroditism (HP:0010459)	3.07544461
12	Ketoacidosis (HP:0001993)	2.99795692
13	Methylmalonic acidemia (HP:0002912)	2.96979310
14	Progressive macrocephaly (HP:0004481)	2.93956317
15	Hyperinsulinemic hypoglycemia (HP:0000825)	2.79924540
16	Renal cortical cysts (HP:0000803)	2.78573108
17	Abnormality of the renal medulla (HP:0100957)	2.71794025
18	Acute necrotizing encephalopathy (HP:0006965)	2.62452573
19	3-Methylglutaconic aciduria (HP:0003535)	2.58859867
20	Type II lissencephaly (HP:0007260)	2.58712721
21	Hemiparesis (HP:0001269)	2.55419098
22	Large for gestational age (HP:0001520)	2.52675829
23	Hypoglycemic coma (HP:0001325)	2.50923623
24	Ketosis (HP:0001946)	2.45869534
25	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.45452008
26	Hypoplasia of the fovea (HP:0007750)	2.45452008
27	Increased CSF lactate (HP:0002490)	2.43898651
28	Thyroiditis (HP:0100646)	2.43072759
29	Mitochondrial inheritance (HP:0001427)	2.42367599
30	Aplasia/hypoplasia of the uterus (HP:0008684)	2.38195808
31	Gait imbalance (HP:0002141)	2.37026884
32	Congenital primary aphakia (HP:0007707)	2.36177783
33	Acute encephalopathy (HP:0006846)	2.32065968
34	Methylmalonic aciduria (HP:0012120)	2.29775804
35	Hypoglycemic seizures (HP:0002173)	2.28389903
36	Abnormality of vitamin B metabolism (HP:0004340)	2.27369226
37	Polydipsia (HP:0001959)	2.26159654
38	Abnormal drinking behavior (HP:0030082)	2.26159654
39	Hyperglycemia (HP:0003074)	2.25924859
40	Abolished electroretinogram (ERG) (HP:0000550)	2.24800715
41	Hepatic necrosis (HP:0002605)	2.24680186
42	Pendular nystagmus (HP:0012043)	2.22550350
43	Gaze-evoked nystagmus (HP:0000640)	2.18844195
44	Neoplasm of the adrenal gland (HP:0100631)	2.17319525
45	Furrowed tongue (HP:0000221)	2.16385670
46	Attenuation of retinal blood vessels (HP:0007843)	2.15524687
47	Tubular atrophy (HP:0000092)	2.14557184
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.14421996
49	Nephrogenic diabetes insipidus (HP:0009806)	2.13599148
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.13541489
51	Abnormality of the labia minora (HP:0012880)	2.13016339
52	Chronic hepatic failure (HP:0100626)	2.11216006
53	Hamartoma of the eye (HP:0010568)	2.09696303
54	Genital tract atresia (HP:0001827)	2.09582154
55	Conjunctival hamartoma (HP:0100780)	2.08283115
56	Increased hepatocellular lipid droplets (HP:0006565)	2.07196670
57	Abnormality of the fovea (HP:0000493)	2.06720280
58	Lipid accumulation in hepatocytes (HP:0006561)	2.05984535
59	Hypsarrhythmia (HP:0002521)	2.00711630
60	Intestinal atresia (HP:0011100)	1.99115104
61	Sclerocornea (HP:0000647)	1.98866307
62	Male pseudohermaphroditism (HP:0000037)	1.98590529
63	EEG with generalized epileptiform discharges (HP:0011198)	1.97506069
64	Hyperventilation (HP:0002883)	1.96917362
65	Hypomagnesemia (HP:0002917)	1.96819297
66	Hepatocellular necrosis (HP:0001404)	1.96444621
67	Epileptiform EEG discharges (HP:0011182)	1.96069274
68	Tongue fasciculations (HP:0001308)	1.94034419
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92434619
70	Vaginal atresia (HP:0000148)	1.90118906
71	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.89105697
72	Agitation (HP:0000713)	1.88728812
73	Cystic liver disease (HP:0006706)	1.86282530
74	Adrenal hypoplasia (HP:0000835)	1.85571896
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85089547
76	Short tibia (HP:0005736)	1.85036011
77	Progressive inability to walk (HP:0002505)	1.84994990
78	Hypoplasia of the uterus (HP:0000013)	1.84522929
79	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.81551601
80	Muscular hypotonia of the trunk (HP:0008936)	1.81276653
81	Congenital, generalized hypertrichosis (HP:0004540)	1.80452205
82	Abnormality of endocrine pancreas physiology (HP:0012093)	1.79293797
83	Abnormality of the pancreatic islet cells (HP:0006476)	1.79293797
84	Cutaneous melanoma (HP:0012056)	1.79128435
85	Postaxial hand polydactyly (HP:0001162)	1.77485307
86	Metaphyseal dysplasia (HP:0100255)	1.76884484
87	Aqueductal stenosis (HP:0002410)	1.75912866
88	Abnormality of macular pigmentation (HP:0008002)	1.75269489
89	Polyuria (HP:0000103)	1.75205808
90	Abnormality of urine glucose concentration (HP:0011016)	1.74928201
91	Glycosuria (HP:0003076)	1.74928201
92	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.72083658
93	Hypoalbuminemia (HP:0003073)	1.71627974
94	Abnormal albumin level (HP:0012116)	1.71627974
95	Pachygyria (HP:0001302)	1.69693150
96	Congenital sensorineural hearing impairment (HP:0008527)	1.69603202
97	Lissencephaly (HP:0001339)	1.68995841
98	Cerebral edema (HP:0002181)	1.68130691
99	Abnormality of the pons (HP:0007361)	1.67977794
100	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.67834172

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.00599119
2	MAP4K2	3.14040403
3	FGFR2	2.78068910
4	GRK1	2.58978833
5	NUAK1	2.41989957
6	WNK3	2.33498754
7	BMPR1B	2.30618316
8	MST4	2.25954874
9	ADRBK2	2.13813684
10	TRIM28	2.02632023
11	ACVR1B	1.99029917
12	EIF2AK3	1.91345778
13	PINK1	1.89162622
14	ERBB3	1.86516086
15	STK39	1.82034878
16	MKNK2	1.68207085
17	PLK2	1.63730970
18	ZAK	1.60758963
19	MAP3K4	1.54284522
20	WNK4	1.52604828
21	OXSR1	1.47600498
22	CASK	1.47209216
23	MAPK13	1.43052474
24	INSRR	1.41293715
25	EIF2AK1	1.34013092
26	PHKG1	1.33075624
27	PHKG2	1.33075624
28	PAK3	1.31962315
29	CSNK1G1	1.25620653
30	BCR	1.25011119
31	CSNK1G2	1.22009045
32	PLK3	1.20894460
33	CSNK1G3	1.14473193
34	TNIK	1.14463933
35	TLK1	1.14396286
36	PRKCE	1.10614129
37	STK24	1.10234496
38	TAOK3	1.01171830
39	PRKCG	0.92218372
40	FER	0.91824847
41	CSNK1A1L	0.90033987
42	STK38L	0.89664122
43	BCKDK	0.87274779
44	NTRK3	0.85999106
45	CAMKK2	0.83696971
46	STK3	0.83451911
47	DAPK2	0.82153066
48	MAP2K7	0.81672812
49	TXK	0.79832409
50	MKNK1	0.77402024
51	PRKD3	0.75210901
52	BRSK2	0.68471099
53	VRK1	0.68351591
54	STK16	0.68018503
55	PNCK	0.67100399
56	WEE1	0.65774003
57	ADRBK1	0.65158316
58	DYRK2	0.57372071
59	NLK	0.56424212
60	MAPKAPK3	0.55806444
61	PTK2B	0.55581513
62	MAP2K6	0.55225634
63	PIK3CA	0.54055891
64	EPHA4	0.52711432
65	STK11	0.50402574
66	PRKCQ	0.47212405
67	PLK1	0.47146768
68	TSSK6	0.46618492
69	CAMK2A	0.46176859
70	CCNB1	0.45949620
71	CSNK1A1	0.45202878
72	AKT3	0.45138634
73	PRKCI	0.44689394
74	FGFR3	0.44477184
75	TEC	0.43681329
76	EIF2AK2	0.43432583
77	PLK4	0.42804197
78	PASK	0.42139441
79	TRPM7	0.41298104
80	PRKACA	0.41292543
81	MINK1	0.39238631
82	OBSCN	0.39099794
83	CAMK2D	0.36999263
84	PRKAA1	0.36712302
85	RPS6KA5	0.35678514
86	MAP3K12	0.34856606
87	MAPKAPK5	0.34565467
88	RPS6KA4	0.33297444
89	PRKCH	0.32886390
90	ATM	0.32861623
91	CSNK1D	0.31501029
92	PRKCZ	0.30270461
93	GRK5	0.30167280
94	IKBKB	0.29913054
95	PRKAA2	0.29603970
96	PRKCA	0.27654355
97	GRK7	0.27419375
98	SRPK1	0.27239370
99	TGFBR1	0.26160569
100	NEK1	0.25497793

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.96546031
2	Protein export_Homo sapiens_hsa03060	3.59732861
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.20763230
4	Butanoate metabolism_Homo sapiens_hsa00650	2.75528206
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.54467536
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.47396851
7	Phototransduction_Homo sapiens_hsa04744	2.35530120
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.09824820
9	Propanoate metabolism_Homo sapiens_hsa00640	1.99019728
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92961884
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.84625485
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81055774
13	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.74379044
14	Parkinsons disease_Homo sapiens_hsa05012	1.72501478
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.70636471
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.69157837
17	RNA polymerase_Homo sapiens_hsa03020	1.64225655
18	Basal transcription factors_Homo sapiens_hsa03022	1.58202128
19	Regulation of autophagy_Homo sapiens_hsa04140	1.55401043
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.53474611
21	Insulin secretion_Homo sapiens_hsa04911	1.52986964
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.52713082
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.52520311
24	Peroxisome_Homo sapiens_hsa04146	1.51050720
25	Homologous recombination_Homo sapiens_hsa03440	1.49889871
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49660449
27	Sulfur metabolism_Homo sapiens_hsa00920	1.48931596
28	RNA degradation_Homo sapiens_hsa03018	1.48264857
29	Proteasome_Homo sapiens_hsa03050	1.40550041
30	Caffeine metabolism_Homo sapiens_hsa00232	1.38073080
31	Nicotine addiction_Homo sapiens_hsa05033	1.36660724
32	Fatty acid elongation_Homo sapiens_hsa00062	1.34500386
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.34095963
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32997903
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.23649920
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23125480
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17387999
38	Alzheimers disease_Homo sapiens_hsa05010	1.09777259
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.06729725
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05631887
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.04054915
42	Type I diabetes mellitus_Homo sapiens_hsa04940	1.02938376
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.01854015
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00021607
45	Huntingtons disease_Homo sapiens_hsa05016	0.98488626
46	Circadian rhythm_Homo sapiens_hsa04710	0.97168102
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.96190367
48	One carbon pool by folate_Homo sapiens_hsa00670	0.95286441
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.94402152
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91072757
51	Olfactory transduction_Homo sapiens_hsa04740	0.87149901
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86144774
53	Taste transduction_Homo sapiens_hsa04742	0.85537987
54	Folate biosynthesis_Homo sapiens_hsa00790	0.84964364
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83266931
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82912255
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82817269
58	GABAergic synapse_Homo sapiens_hsa04727	0.82379302
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81853557
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77555416
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76792972
62	Morphine addiction_Homo sapiens_hsa05032	0.76561962
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75850563
64	Retinol metabolism_Homo sapiens_hsa00830	0.75056045
65	Circadian entrainment_Homo sapiens_hsa04713	0.74204571
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73850378
67	Purine metabolism_Homo sapiens_hsa00230	0.73539367
68	Serotonergic synapse_Homo sapiens_hsa04726	0.70356381
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.69243567
70	Metabolic pathways_Homo sapiens_hsa01100	0.68871729
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68813272
72	ABC transporters_Homo sapiens_hsa02010	0.65987586
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.63414790
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62843996
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.62311926
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58827584
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.58184498
78	Amphetamine addiction_Homo sapiens_hsa05031	0.58002754
79	Fatty acid degradation_Homo sapiens_hsa00071	0.56309089
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.53964895
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53427113
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49583852
83	Mismatch repair_Homo sapiens_hsa03430	0.48812634
84	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48207461
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48156969
86	Type II diabetes mellitus_Homo sapiens_hsa04930	0.48082465
87	Mineral absorption_Homo sapiens_hsa04978	0.47711884
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47603082
89	Salivary secretion_Homo sapiens_hsa04970	0.46270272
90	Renin secretion_Homo sapiens_hsa04924	0.46196898
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45925370
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43562694
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42577398
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41914041
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40002642
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.39485590
97	Oocyte meiosis_Homo sapiens_hsa04114	0.36523846
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36469135
99	RNA transport_Homo sapiens_hsa03013	0.35256055
100	Nucleotide excision repair_Homo sapiens_hsa03420	0.32452754

THAP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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