THAP5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)7.98736978
2cell wall macromolecule metabolic process (GO:0044036)6.65495106
3DNA unwinding involved in DNA replication (GO:0006268)6.01165939
4DNA strand elongation involved in DNA replication (GO:0006271)5.51759445
5DNA strand elongation (GO:0022616)5.22855684
6DNA replication checkpoint (GO:0000076)5.18868713
7chromatin remodeling at centromere (GO:0031055)5.11344868
8DNA replication initiation (GO:0006270)4.89279641
9CENP-A containing nucleosome assembly (GO:0034080)4.77922774
10mitotic sister chromatid segregation (GO:0000070)4.73876896
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.72644826
12ATP synthesis coupled proton transport (GO:0015986)4.58596276
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.58596276
14kinetochore assembly (GO:0051382)4.55798261
15sister chromatid segregation (GO:0000819)4.53855316
16resolution of meiotic recombination intermediates (GO:0000712)4.44027092
17regulation of double-strand break repair via homologous recombination (GO:0010569)4.24919662
18kinetochore organization (GO:0051383)4.19844050
19histone exchange (GO:0043486)4.18841736
20telomere maintenance via semi-conservative replication (GO:0032201)4.09978321
21centriole replication (GO:0007099)3.89321462
22proteasome assembly (GO:0043248)3.83374349
23transcription from mitochondrial promoter (GO:0006390)3.60026873
24ventricular cardiac muscle cell development (GO:0055015)3.59663789
25replication fork processing (GO:0031297)3.59621646
26DNA replication-independent nucleosome assembly (GO:0006336)3.57706611
27DNA replication-independent nucleosome organization (GO:0034724)3.57706611
28histone mRNA metabolic process (GO:0008334)3.57089237
29regulation of cilium movement (GO:0003352)3.55683532
30DNA ligation (GO:0006266)3.53642868
31DNA double-strand break processing (GO:0000729)3.50404248
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47154233
33telomere maintenance via recombination (GO:0000722)3.45294784
34mitotic recombination (GO:0006312)3.39751127
35mitotic metaphase plate congression (GO:0007080)3.38735493
36maturation of 5.8S rRNA (GO:0000460)3.35127685
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33129645
38myelin assembly (GO:0032288)3.30953815
39mitotic G2/M transition checkpoint (GO:0044818)3.30927873
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.30405067
41chromosome segregation (GO:0007059)3.27667523
42terpenoid biosynthetic process (GO:0016114)3.27398021
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.22507202
44recombinational repair (GO:0000725)3.21360184
45diterpenoid biosynthetic process (GO:0016102)3.19225782
46ATP biosynthetic process (GO:0006754)3.18456958
47rRNA modification (GO:0000154)3.17485853
48DNA replication-dependent nucleosome assembly (GO:0006335)3.17400878
49DNA replication-dependent nucleosome organization (GO:0034723)3.17400878
50metaphase plate congression (GO:0051310)3.16805602
51microtubule depolymerization (GO:0007019)3.14552276
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13949857
53double-strand break repair via homologous recombination (GO:0000724)3.10798076
54DNA catabolic process, exonucleolytic (GO:0000738)3.04956995
55regulation of mitochondrial translation (GO:0070129)3.02740564
56respiratory electron transport chain (GO:0022904)3.01567283
57regulation of development, heterochronic (GO:0040034)3.00828499
58negative regulation of DNA recombination (GO:0045910)3.00483655
59regulation of centriole replication (GO:0046599)2.98590173
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97985680
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97023706
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95127623
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.95127623
64NADH dehydrogenase complex assembly (GO:0010257)2.95127623
65electron transport chain (GO:0022900)2.94781497
66regulation of timing of cell differentiation (GO:0048505)2.92719591
67cullin deneddylation (GO:0010388)2.91917282
68mitochondrial respiratory chain complex assembly (GO:0033108)2.91900805
69rRNA methylation (GO:0031167)2.90879285
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89942268
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89430731
72microtubule polymerization or depolymerization (GO:0031109)2.89007400
73heart contraction (GO:0060047)2.88908388
74heart process (GO:0003015)2.88908388
75purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87370932
76G1/S transition of mitotic cell cycle (GO:0000082)2.87295285
77cell cycle G1/S phase transition (GO:0044843)2.87295285
78purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86217489
79nonmotile primary cilium assembly (GO:0035058)2.85347348
80ribosome assembly (GO:0042255)2.85211853
81protein K6-linked ubiquitination (GO:0085020)2.83658211
82protein localization to chromosome (GO:0034502)2.83525123
83telomere maintenance via telomere lengthening (GO:0010833)2.83064988
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82430166
85mitochondrial RNA metabolic process (GO:0000959)2.80396037
86double-strand break repair via nonhomologous end joining (GO:0006303)2.77957940
87non-recombinational repair (GO:0000726)2.77957940
88somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.77828758
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.77828758
90isotype switching (GO:0045190)2.77828758
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.77744618
92DNA deamination (GO:0045006)2.77244045
93protein complex biogenesis (GO:0070271)2.76534522
94DNA damage response, detection of DNA damage (GO:0042769)2.76062320
95regulation of centrosome cycle (GO:0046605)2.75847690
96protein localization to kinetochore (GO:0034501)2.75526634
97acrosome reaction (GO:0007340)2.75509292
98negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.75259454
99attachment of spindle microtubules to kinetochore (GO:0008608)2.73040468
100centrosome organization (GO:0051297)2.72947661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.54186171
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.76947668
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.32897815
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.63109651
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.41624862
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.30719345
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24573727
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.19779953
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04799624
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.00117388
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.98559519
12ELK1_19687146_ChIP-ChIP_HELA_Human2.72223327
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.68775305
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54323025
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47098234
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43183869
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.35208885
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33596986
19VDR_22108803_ChIP-Seq_LS180_Human2.27816547
20VDR_23849224_ChIP-Seq_CD4+_Human2.27325424
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.26538229
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08684158
23FOXP3_21729870_ChIP-Seq_TREG_Human2.07585569
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96744421
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94448779
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92258585
27AR_21909140_ChIP-Seq_LNCAP_Human1.89733764
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84498957
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82002363
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81107687
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77704490
32EWS_26573619_Chip-Seq_HEK293_Human1.75366334
33ZNF274_21170338_ChIP-Seq_K562_Hela1.72882367
34MYC_18940864_ChIP-ChIP_HL60_Human1.70998216
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67941409
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67653050
37GABP_19822575_ChIP-Seq_HepG2_Human1.67380171
38FUS_26573619_Chip-Seq_HEK293_Human1.66911635
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66376675
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63233585
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55993320
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.53747319
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50576574
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50020990
45DCP1A_22483619_ChIP-Seq_HELA_Human1.47517976
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43093292
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38156499
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.35667433
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34353646
50TTF2_22483619_ChIP-Seq_HELA_Human1.31483577
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28863614
52E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25072142
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22125607
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20622403
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.19583899
56IGF1R_20145208_ChIP-Seq_DFB_Human1.18544768
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.17639999
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13865818
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12617350
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11487013
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09982312
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.05591703
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02391050
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01674501
65XRN2_22483619_ChIP-Seq_HELA_Human1.01603488
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00775920
67IRF1_19129219_ChIP-ChIP_H3396_Human1.00690054
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.00174842
69TAF15_26573619_Chip-Seq_HEK293_Human0.99471430
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98117460
71CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97994631
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97381079
73CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96711376
74YY1_21170310_ChIP-Seq_MESCs_Mouse0.93741861
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89326721
76SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89082221
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88018795
78POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86487974
79KDM5A_27292631_Chip-Seq_BREAST_Human0.85283736
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84920182
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.84785713
82NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82742374
83OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82567798
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79693018
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78058091
86TP53_22573176_ChIP-Seq_HFKS_Human0.75397078
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75353214
88P300_19829295_ChIP-Seq_ESCs_Human0.73893141
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73753556
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73207407
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72276315
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72207060
93CIITA_25753668_ChIP-Seq_RAJI_Human0.72180959
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.72175232
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.71363860
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.70531880
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.70531880
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.69878202
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69765876
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.68147126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.53599018
2MP0010030_abnormal_orbit_morphology3.64770148
3MP0003111_abnormal_nucleus_morphology3.56027747
4MP0000566_synostosis3.35512237
5MP0003693_abnormal_embryo_hatching3.05944253
6MP0008058_abnormal_DNA_repair2.91044014
7MP0000372_irregular_coat_pigmentation2.89277668
8MP0004957_abnormal_blastocyst_morpholog2.89130966
9MP0009697_abnormal_copulation2.82875984
10MP0006292_abnormal_olfactory_placode2.75303851
11MP0008789_abnormal_olfactory_epithelium2.74125320
12MP0003077_abnormal_cell_cycle2.71756107
13MP0003806_abnormal_nucleotide_metabolis2.65322287
14MP0003136_yellow_coat_color2.35415059
15MP0002938_white_spotting2.25981360
16MP0003123_paternal_imprinting2.25837925
17MP0000015_abnormal_ear_pigmentation2.16325912
18MP0008932_abnormal_embryonic_tissue2.11935863
19MP0003950_abnormal_plasma_membrane2.10739417
20MP0003786_premature_aging2.04306043
21MP0008260_abnormal_autophagy2.02227982
22MP0001346_abnormal_lacrimal_gland1.95016388
23MP0008007_abnormal_cellular_replicative1.84969614
24MP0003186_abnormal_redox_activity1.76715741
25MP0002163_abnormal_gland_morphology1.76637457
26MP0003718_maternal_effect1.72360234
27MP0002233_abnormal_nose_morphology1.69680574
28MP0006036_abnormal_mitochondrial_physio1.64356232
29MP0005551_abnormal_eye_electrophysiolog1.63242978
30MP0005379_endocrine/exocrine_gland_phen1.62317414
31MP0005499_abnormal_olfactory_system1.61728471
32MP0005394_taste/olfaction_phenotype1.61728471
33MP0006035_abnormal_mitochondrial_morpho1.55602533
34MP0008057_abnormal_DNA_replication1.55194591
35MP0002095_abnormal_skin_pigmentation1.48325851
36MP0004215_abnormal_myocardial_fiber1.48190752
37MP0005410_abnormal_fertilization1.46535612
38MP0005408_hypopigmentation1.44388544
39MP0001984_abnormal_olfaction1.33844498
40MP0002210_abnormal_sex_determination1.33613165
41MP0003656_abnormal_erythrocyte_physiolo1.33472193
42MP0004147_increased_porphyrin_level1.33245389
43MP0002638_abnormal_pupillary_reflex1.31705119
44MP0002837_dystrophic_cardiac_calcinosis1.28317043
45MP0008875_abnormal_xenobiotic_pharmacok1.28263789
46MP0008877_abnormal_DNA_methylation1.27713021
47MP0002160_abnormal_reproductive_system1.26387179
48MP0003938_abnormal_ear_development1.23043265
49MP0000358_abnormal_cell_content/1.20951161
50MP0001929_abnormal_gametogenesis1.19880824
51MP0002876_abnormal_thyroid_physiology1.19467434
52MP0000631_abnormal_neuroendocrine_gland1.14477764
53MP0003567_abnormal_fetal_cardiomyocyte1.14396417
54MP0000639_abnormal_adrenal_gland1.10452366
55MP0000350_abnormal_cell_proliferation1.01601810
56MP0006072_abnormal_retinal_apoptosis1.01388714
57MP0003941_abnormal_skin_development1.00372463
58MP0005360_urolithiasis0.99370790
59MP0003698_abnormal_male_reproductive0.92587556
60MP0004197_abnormal_fetal_growth/weight/0.91613276
61MP0001485_abnormal_pinna_reflex0.90373962
62MP0005253_abnormal_eye_physiology0.90112785
63MP0003880_abnormal_central_pattern0.89530238
64MP0001270_distended_abdomen0.88905681
65MP0001697_abnormal_embryo_size0.88663961
66MP0000653_abnormal_sex_gland0.88255847
67MP0005075_abnormal_melanosome_morpholog0.87365250
68MP0001145_abnormal_male_reproductive0.87142998
69MP0002102_abnormal_ear_morphology0.86381770
70MP0009703_decreased_birth_body0.85655694
71MP0001324_abnormal_eye_pigmentation0.83870461
72MP0008872_abnormal_physiological_respon0.81312475
73MP0003755_abnormal_palate_morphology0.80830312
74MP0001119_abnormal_female_reproductive0.79664748
75MP0001177_atelectasis0.79656516
76MP0003937_abnormal_limbs/digits/tail_de0.79364239
77MP0004145_abnormal_muscle_electrophysio0.78124393
78MP0001186_pigmentation_phenotype0.77611139
79MP0002085_abnormal_embryonic_tissue0.76338272
80MP0005389_reproductive_system_phenotype0.73274439
81MP0002075_abnormal_coat/hair_pigmentati0.68166743
82MP0001286_abnormal_eye_development0.66679527
83MP0000313_abnormal_cell_death0.66238903
84MP0001293_anophthalmia0.65468232
85MP0005174_abnormal_tail_pigmentation0.65427514
86MP0005391_vision/eye_phenotype0.65249230
87MP0008873_increased_physiological_sensi0.64602635
88MP0003121_genomic_imprinting0.64442818
89MP0001727_abnormal_embryo_implantation0.62882958
90MP0005332_abnormal_amino_acid0.62225443
91MP0001188_hyperpigmentation0.61871565
92MP0009046_muscle_twitch0.61829280
93MP0002080_prenatal_lethality0.60755757
94MP0000049_abnormal_middle_ear0.60276705
95MP0005195_abnormal_posterior_eye0.57981080
96MP0005670_abnormal_white_adipose0.57535879
97MP0002161_abnormal_fertility/fecundity0.57370068
98MP0000647_abnormal_sebaceous_gland0.56741555
99MP0002019_abnormal_tumor_incidence0.55220891
100MP0004133_heterotaxia0.54886329

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)4.38549809
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.15312826
3Chromsome breakage (HP:0040012)3.92697190
4Stenosis of the external auditory canal (HP:0000402)3.90825664
5Abnormality of the labia minora (HP:0012880)3.82468802
6Acute necrotizing encephalopathy (HP:0006965)3.68828998
7Mitochondrial inheritance (HP:0001427)3.52788836
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.35933553
9Acute encephalopathy (HP:0006846)3.24282030
10Morphological abnormality of the inner ear (HP:0011390)3.21247545
11Abnormality of chromosome stability (HP:0003220)3.18867489
12Abnormal mitochondria in muscle tissue (HP:0008316)3.10815304
13Meckel diverticulum (HP:0002245)3.08128817
14Progressive macrocephaly (HP:0004481)2.97923502
15Absent septum pellucidum (HP:0001331)2.94733301
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.94189591
17Decreased activity of mitochondrial respiratory chain (HP:0008972)2.94189591
18Duodenal stenosis (HP:0100867)2.89215414
19Small intestinal stenosis (HP:0012848)2.89215414
20Abnormality of the ileum (HP:0001549)2.88087438
21Increased CSF lactate (HP:0002490)2.73301638
22Cerebral edema (HP:0002181)2.70847142
23Abnormality of the preputium (HP:0100587)2.65910080
24Facial cleft (HP:0002006)2.65618481
25Broad distal phalanx of finger (HP:0009836)2.62683751
26Abnormality of the duodenum (HP:0002246)2.40954884
27Abnormality of midbrain morphology (HP:0002418)2.35430933
28Molar tooth sign on MRI (HP:0002419)2.35430933
29Increased hepatocellular lipid droplets (HP:0006565)2.32256555
30Abnormality of lateral ventricle (HP:0030047)2.30983034
31Triphalangeal thumb (HP:0001199)2.30089115
32Abnormality of the septum pellucidum (HP:0007375)2.29280906
33Clubbing of toes (HP:0100760)2.29171889
34Abnormality of the carotid arteries (HP:0005344)2.27303046
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26559991
36Median cleft lip (HP:0000161)2.25308097
37Degeneration of anterior horn cells (HP:0002398)2.16979785
38Abnormality of the anterior horn cell (HP:0006802)2.16979785
39Conical tooth (HP:0000698)2.16137552
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.15297251
41Hypoplasia of the fovea (HP:0007750)2.15297251
42Overriding aorta (HP:0002623)2.11116919
43Congenital stationary night blindness (HP:0007642)2.10940353
44Overlapping toe (HP:0001845)2.10363707
45Increased serum lactate (HP:0002151)2.09821751
46Hypoplastic pelvis (HP:0008839)2.08702782
47Lactic acidosis (HP:0003128)2.08646554
48Acanthocytosis (HP:0001927)2.07712882
49Lipid accumulation in hepatocytes (HP:0006561)2.07581962
50Breast hypoplasia (HP:0003187)2.06681068
51Renal Fanconi syndrome (HP:0001994)2.06057690
52Hypokinesia (HP:0002375)2.05133118
53Horseshoe kidney (HP:0000085)2.03843585
54Respiratory failure (HP:0002878)2.03539958
55Abnormality of glycine metabolism (HP:0010895)2.03170659
56Abnormality of serine family amino acid metabolism (HP:0010894)2.03170659
57Birth length less than 3rd percentile (HP:0003561)2.02707014
58Dysphonia (HP:0001618)2.01154723
59Hyperglycinemia (HP:0002154)2.00300713
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99492980
61Type II lissencephaly (HP:0007260)1.99373570
62Exercise intolerance (HP:0003546)1.97727780
63Abnormality of methionine metabolism (HP:0010901)1.96786954
6411 pairs of ribs (HP:0000878)1.96296826
65Hepatocellular necrosis (HP:0001404)1.95694702
66Increased serum pyruvate (HP:0003542)1.95556552
67Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95407929
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94795587
69Abnormal lung lobation (HP:0002101)1.94392514
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94343199
71Abnormality of the pons (HP:0007361)1.94320944
72Esophageal atresia (HP:0002032)1.93882418
73X-linked dominant inheritance (HP:0001423)1.90709816
74Sloping forehead (HP:0000340)1.88121990
75Absent thumb (HP:0009777)1.88081567
76Hyperglycinuria (HP:0003108)1.88033440
77Abnormality of the renal collecting system (HP:0004742)1.87647194
78Myelodysplasia (HP:0002863)1.87606323
79Overfolded helix (HP:0000396)1.87079900
80Nephroblastoma (Wilms tumor) (HP:0002667)1.86872998
81Abnormality of the fovea (HP:0000493)1.86429134
82Abnormal number of incisors (HP:0011064)1.86017942
83Hypoplastic female external genitalia (HP:0012815)1.85623809
843-Methylglutaconic aciduria (HP:0003535)1.85183549
85Irregular epiphyses (HP:0010582)1.83837584
86Tubulointerstitial nephritis (HP:0001970)1.81816142
87Carpal bone hypoplasia (HP:0001498)1.80471785
88Poor speech (HP:0002465)1.79823332
89Exercise-induced muscle cramps (HP:0003710)1.79256600
90Type I transferrin isoform profile (HP:0003642)1.79131422
91Dyskinesia (HP:0100660)1.78948233
92Medial flaring of the eyebrow (HP:0010747)1.76445852
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76428474
94Duplicated collecting system (HP:0000081)1.75798709
95Embryonal renal neoplasm (HP:0011794)1.75788895
96Hypoplastic labia majora (HP:0000059)1.75672347
97Cleft eyelid (HP:0000625)1.74631860
98Long nose (HP:0003189)1.74545996
99Facial hemangioma (HP:0000329)1.73424843
100Hepatic necrosis (HP:0002605)1.71881581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.42562466
2EIF2AK14.10838673
3BUB13.96005131
4CDC73.77273429
5STK38L3.73359964
6PLK43.37644895
7EIF2AK32.65560410
8NEK12.61602943
9BRSK22.59436894
10NUAK11.87456411
11BRSK11.75278723
12BLK1.63255682
13BCKDK1.59725710
14PLK31.58229348
15BMPR1B1.51474591
16NEK21.51341012
17ZAK1.49957440
18CASK1.49345360
19TTK1.48165757
20EPHA41.47932714
21PLK11.45169493
22MKNK11.42382798
23ARAF1.41880415
24MKNK21.40214632
25DYRK31.38382434
26EIF2AK21.26636615
27CDK31.26419463
28TSSK61.26004033
29PNCK1.21177134
30WNK31.20137904
31RPS6KA41.19911586
32PDK21.19512822
33PLK21.17835854
34MST41.16167065
35ERBB31.08975713
36STK391.07701686
37TRIM281.01514422
38AURKB1.01305853
39SRPK10.96625444
40FGFR20.96438293
41VRK10.94997968
42ATR0.94592030
43MAP3K90.93442232
44PAK30.92553898
45STK380.87748531
46CDK70.86841833
47BCR0.85883910
48CHEK20.85490824
49STK30.83615943
50MELK0.82007044
51ATM0.81857678
52WNK10.80518721
53VRK20.79808678
54PINK10.78313404
55NME20.77705819
56GRK10.75690963
57CSNK1G30.75150053
58KDR0.74056353
59CSNK1G20.70891452
60FRK0.67950736
61DMPK0.65790624
62CHEK10.64261227
63STK160.63915816
64INSRR0.58205092
65RAF10.57559049
66MAP3K80.56805235
67CSNK1G10.56775041
68CSNK1A1L0.56384409
69MAPKAPK50.56260418
70LIMK10.55911210
71RIPK10.54648926
72CAMKK20.54181746
73BRAF0.54164831
74CSNK2A10.52887472
75TGFBR10.52755252
76CSNK2A20.46434895
77CDK10.45809242
78WNK40.44740805
79STK40.43483542
80MAP3K40.42323535
81ABL20.41475208
82TAF10.41453606
83PRKCI0.41250854
84OXSR10.41103942
85ACVR1B0.39881081
86PRKCE0.37478918
87FGFR10.36892245
88CSNK1D0.35861409
89MARK30.35125122
90RPS6KA50.33710376
91CDK80.33331896
92CDK20.33313368
93ILK0.32652500
94MAPK130.32050909
95TNK20.30768151
96MAP4K20.29853664
97PRKDC0.29606218
98DYRK20.28992011
99MINK10.28625168
100CDK190.28581566

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79033571
2Mismatch repair_Homo sapiens_hsa034303.58628112
3Protein export_Homo sapiens_hsa030603.54580908
4Proteasome_Homo sapiens_hsa030503.49662228
5Oxidative phosphorylation_Homo sapiens_hsa001903.07154420
6Homologous recombination_Homo sapiens_hsa034403.04404354
7Fanconi anemia pathway_Homo sapiens_hsa034602.95589774
8Parkinsons disease_Homo sapiens_hsa050122.86108967
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53866551
10Non-homologous end-joining_Homo sapiens_hsa034502.49691564
11Ribosome_Homo sapiens_hsa030102.31720375
12Huntingtons disease_Homo sapiens_hsa050162.22498155
13Nucleotide excision repair_Homo sapiens_hsa034202.10454472
14Sulfur metabolism_Homo sapiens_hsa009201.90584940
15RNA polymerase_Homo sapiens_hsa030201.89458690
16Propanoate metabolism_Homo sapiens_hsa006401.80717520
17Alzheimers disease_Homo sapiens_hsa050101.77173583
18RNA degradation_Homo sapiens_hsa030181.76958696
19Base excision repair_Homo sapiens_hsa034101.75320266
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73641552
21Basal transcription factors_Homo sapiens_hsa030221.69893895
22Spliceosome_Homo sapiens_hsa030401.59293368
23RNA transport_Homo sapiens_hsa030131.57229184
24Cell cycle_Homo sapiens_hsa041101.54692279
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48688497
26Pyrimidine metabolism_Homo sapiens_hsa002401.46580809
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45243803
28One carbon pool by folate_Homo sapiens_hsa006701.41127387
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40992545
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33656753
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.29995666
32Pyruvate metabolism_Homo sapiens_hsa006201.27518448
33Sulfur relay system_Homo sapiens_hsa041221.25838221
34p53 signaling pathway_Homo sapiens_hsa041151.20784920
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20756486
36Glutathione metabolism_Homo sapiens_hsa004801.20612933
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18604397
38Regulation of autophagy_Homo sapiens_hsa041401.17453107
39Selenocompound metabolism_Homo sapiens_hsa004501.11920560
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09894821
41Steroid biosynthesis_Homo sapiens_hsa001001.08521831
42mRNA surveillance pathway_Homo sapiens_hsa030151.06555447
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01569917
44Purine metabolism_Homo sapiens_hsa002300.98376955
45Folate biosynthesis_Homo sapiens_hsa007900.94975377
46Vitamin B6 metabolism_Homo sapiens_hsa007500.93106544
47Tryptophan metabolism_Homo sapiens_hsa003800.92183625
48Chemical carcinogenesis_Homo sapiens_hsa052040.89431212
49Retinol metabolism_Homo sapiens_hsa008300.88514545
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88251040
51Cardiac muscle contraction_Homo sapiens_hsa042600.88114939
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87352162
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84041665
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79428573
55Phototransduction_Homo sapiens_hsa047440.76836385
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75248988
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74569313
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73348906
59Peroxisome_Homo sapiens_hsa041460.70289709
60Metabolic pathways_Homo sapiens_hsa011000.70011881
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64637959
62Oocyte meiosis_Homo sapiens_hsa041140.64282740
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.63924808
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59664137
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56423688
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.54559485
67Linoleic acid metabolism_Homo sapiens_hsa005910.52868172
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50950878
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.50057318
70Circadian rhythm_Homo sapiens_hsa047100.47232830
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44531245
72Caffeine metabolism_Homo sapiens_hsa002320.42498843
73Biosynthesis of amino acids_Homo sapiens_hsa012300.39036531
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36637271
75Glycerolipid metabolism_Homo sapiens_hsa005610.35724931
76N-Glycan biosynthesis_Homo sapiens_hsa005100.34588944
77Epstein-Barr virus infection_Homo sapiens_hsa051690.34209911
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33986514
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33981639
80Nitrogen metabolism_Homo sapiens_hsa009100.33756162
81Carbon metabolism_Homo sapiens_hsa012000.33669068
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33627476
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33389802
84Fatty acid metabolism_Homo sapiens_hsa012120.32989600
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32494090
86Arachidonic acid metabolism_Homo sapiens_hsa005900.30354122
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29602579
88Hedgehog signaling pathway_Homo sapiens_hsa043400.28945118
89Renin-angiotensin system_Homo sapiens_hsa046140.28177779
90Fatty acid degradation_Homo sapiens_hsa000710.27180688
91Vitamin digestion and absorption_Homo sapiens_hsa049770.24457616
92Arginine and proline metabolism_Homo sapiens_hsa003300.24086139
93Fat digestion and absorption_Homo sapiens_hsa049750.21969788
94Pentose phosphate pathway_Homo sapiens_hsa000300.21011702
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20232925
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19000772
97Tyrosine metabolism_Homo sapiens_hsa003500.16952619
98Fatty acid elongation_Homo sapiens_hsa000620.13900027
99Galactose metabolism_Homo sapiens_hsa000520.13745062
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.13590051

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