THAP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.16189224
2response to pheromone (GO:0019236)4.14392426
3L-fucose catabolic process (GO:0042355)3.99263801
4fucose catabolic process (GO:0019317)3.99263801
5L-fucose metabolic process (GO:0042354)3.99263801
6nonmotile primary cilium assembly (GO:0035058)3.92039650
7indolalkylamine metabolic process (GO:0006586)3.86934144
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86818465
9water-soluble vitamin biosynthetic process (GO:0042364)3.84807589
10epithelial cilium movement (GO:0003351)3.77277838
11kynurenine metabolic process (GO:0070189)3.77129279
12tryptophan catabolic process (GO:0006569)3.73126345
13indole-containing compound catabolic process (GO:0042436)3.73126345
14indolalkylamine catabolic process (GO:0046218)3.73126345
15piRNA metabolic process (GO:0034587)3.63130537
16platelet dense granule organization (GO:0060155)3.57579311
17superoxide anion generation (GO:0042554)3.56821813
18G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.54044533
19GPI anchor biosynthetic process (GO:0006506)3.51416116
20tryptophan metabolic process (GO:0006568)3.41779161
21neural tube formation (GO:0001841)3.39164076
22limb bud formation (GO:0060174)3.36998647
23negative regulation of execution phase of apoptosis (GO:1900118)3.33879875
24nucleotide transmembrane transport (GO:1901679)3.33139717
25detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.30192692
26GPI anchor metabolic process (GO:0006505)3.26821113
27response to peptidoglycan (GO:0032494)3.26812919
28respiratory chain complex IV assembly (GO:0008535)3.26451519
29preassembly of GPI anchor in ER membrane (GO:0016254)3.24980866
30regulation of cilium movement (GO:0003352)3.24245974
31cilium morphogenesis (GO:0060271)3.21538779
32intraciliary transport (GO:0042073)3.21345603
33axoneme assembly (GO:0035082)3.21039112
34keratinocyte development (GO:0003334)3.19971806
35positive regulation of toll-like receptor signaling pathway (GO:0034123)3.18273265
36signal peptide processing (GO:0006465)3.17654414
37developmental pigmentation (GO:0048066)3.15655067
38adenosine metabolic process (GO:0046085)3.13695883
39cilium movement (GO:0003341)3.12685275
40detection of light stimulus involved in visual perception (GO:0050908)3.09342022
41detection of light stimulus involved in sensory perception (GO:0050962)3.09342022
42protein complex biogenesis (GO:0070271)3.08361335
43rRNA catabolic process (GO:0016075)3.04792608
44indole-containing compound metabolic process (GO:0042430)3.03187408
45protein K11-linked deubiquitination (GO:0035871)3.01709641
46cilium or flagellum-dependent cell motility (GO:0001539)3.01644816
47recombinational repair (GO:0000725)3.00151088
48double-strand break repair via homologous recombination (GO:0000724)2.99845330
49centriole assembly (GO:0098534)2.99833660
50negative regulation of telomere maintenance (GO:0032205)2.99416536
51cellular ketone body metabolic process (GO:0046950)2.99102334
52cilium organization (GO:0044782)2.98100267
53cytochrome complex assembly (GO:0017004)2.97094394
54DNA deamination (GO:0045006)2.96763766
55reflex (GO:0060004)2.95881605
56regulation of glucokinase activity (GO:0033131)2.95201777
57regulation of hexokinase activity (GO:1903299)2.95201777
58synapsis (GO:0007129)2.94498685
59DNA integration (GO:0015074)2.92510200
60cilium assembly (GO:0042384)2.92025939
61replication fork processing (GO:0031297)2.91718394
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91671460
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.91671460
64modulation by symbiont of host immune response (GO:0052553)2.91671460
65positive regulation by symbiont of host defense response (GO:0052509)2.91671460
66modulation by symbiont of host defense response (GO:0052031)2.91671460
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91671460
68negative regulation of mast cell activation (GO:0033004)2.91415938
69detection of bacterium (GO:0016045)2.91388387
70regulation of somitogenesis (GO:0014807)2.91121131
71DNA double-strand break processing (GO:0000729)2.90298922
72face development (GO:0060324)2.89923802
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87860140
74detection of other organism (GO:0098543)2.87707056
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.87345973
76NADH dehydrogenase complex assembly (GO:0010257)2.87345973
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87345973
78reciprocal meiotic recombination (GO:0007131)2.84477299
79reciprocal DNA recombination (GO:0035825)2.84477299
80regulation of telomere maintenance (GO:0032204)2.84339886
81somite development (GO:0061053)2.84287003
82histone H2B ubiquitination (GO:0033523)2.82923623
83mitochondrial respiratory chain complex assembly (GO:0033108)2.82916100
84regulation of activation of Janus kinase activity (GO:0010533)2.82836058
85oligosaccharide catabolic process (GO:0009313)2.82178963
86neutrophil activation involved in immune response (GO:0002283)2.82057179
87glucosamine-containing compound catabolic process (GO:1901072)2.81022541
88neutrophil activation (GO:0042119)2.80915625
89central nervous system myelination (GO:0022010)2.79163253
90axon ensheathment in central nervous system (GO:0032291)2.79163253
91positive regulation of cellular amine metabolic process (GO:0033240)2.78160852
92DNA methylation involved in gamete generation (GO:0043046)2.73540080
93purinergic nucleotide receptor signaling pathway (GO:0035590)2.72465967
94photoreceptor cell development (GO:0042461)2.72016629
95positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.71508462
96regulation of meiosis I (GO:0060631)2.70978191
97prenylation (GO:0097354)2.70607723
98protein prenylation (GO:0018342)2.70607723
99interferon-gamma production (GO:0032609)2.69889721
100protein K6-linked ubiquitination (GO:0085020)2.69222040
101ketone body metabolic process (GO:1902224)2.68730124
102ceramide catabolic process (GO:0046514)2.67639523
103regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.67495987
104glycerophospholipid catabolic process (GO:0046475)2.67483761
105S-adenosylmethionine metabolic process (GO:0046500)2.67018919
106primary amino compound metabolic process (GO:1901160)2.66963120
107amino sugar catabolic process (GO:0046348)2.66468712
108positive regulation of interleukin-1 beta secretion (GO:0050718)2.66386937
109regulation of timing of cell differentiation (GO:0048505)2.65543759
110RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65366439
111protein localization to cilium (GO:0061512)2.65310135
112dopamine transport (GO:0015872)2.65218087
113nucleobase catabolic process (GO:0046113)2.64690510
114neuron fate determination (GO:0048664)2.64302476
115protein-cofactor linkage (GO:0018065)2.63657768
116negative regulation of transcription by competitive promoter binding (GO:0010944)2.63045172
117regulation of action potential (GO:0098900)2.61607231
118kidney morphogenesis (GO:0060993)2.60965169
119serotonin metabolic process (GO:0042428)2.60931610
120glycosphingolipid catabolic process (GO:0046479)2.60482793
121histone H3-K4 trimethylation (GO:0080182)2.60036288
122ubiquinone biosynthetic process (GO:0006744)2.59725726
123dendritic cell chemotaxis (GO:0002407)2.59539201
124female gonad development (GO:0008585)2.58977269
125presynaptic membrane assembly (GO:0097105)2.58081643
126establishment of protein localization to Golgi (GO:0072600)2.57757897
127regulation of chemokine secretion (GO:0090196)2.57102220
128mesenchymal cell differentiation involved in kidney development (GO:0072161)2.56834890
129mesenchymal cell differentiation involved in renal system development (GO:2001012)2.56834890
130long-chain fatty acid biosynthetic process (GO:0042759)2.56800435
131sphingoid metabolic process (GO:0046519)2.56601154
132modulation by virus of host process (GO:0019054)2.56595640
133ubiquinone metabolic process (GO:0006743)2.56285906
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.54945037
135lipoxygenase pathway (GO:0019372)2.54903405
136left/right axis specification (GO:0070986)2.54702113
137lymphoid progenitor cell differentiation (GO:0002320)2.53845438
138positive regulation of oligodendrocyte differentiation (GO:0048714)2.53285333
139sulfation (GO:0051923)2.53017903
140centriole replication (GO:0007099)2.52259693
141polyol catabolic process (GO:0046174)2.52097046
142male meiosis I (GO:0007141)2.51380067
143C-terminal protein lipidation (GO:0006501)2.50045661
144behavioral response to ethanol (GO:0048149)2.50036502
145inositol phosphate catabolic process (GO:0071545)2.49468548
146resolution of meiotic recombination intermediates (GO:0000712)2.49314809
147granulocyte activation (GO:0036230)2.49246809
148pyrimidine nucleobase catabolic process (GO:0006208)2.48750643
149amino acid salvage (GO:0043102)2.48599565
150L-methionine salvage (GO:0071267)2.48599565
151L-methionine biosynthetic process (GO:0071265)2.48599565
152spinal cord motor neuron differentiation (GO:0021522)2.46954855
153neuronal action potential (GO:0019228)2.46783349
154positive regulation of action potential (GO:0045760)2.46743781
155regulation of mast cell degranulation (GO:0043304)2.46554443
156positive regulation of interleukin-1 secretion (GO:0050716)2.46394926
157anterograde synaptic vesicle transport (GO:0048490)2.46003948
158I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.44584567
159regulation of interleukin-8 secretion (GO:2000482)2.44568683
160dendritic cell migration (GO:0036336)2.42014147
161interleukin-1-mediated signaling pathway (GO:0070498)2.41785121
162positive regulation of cellular amide metabolic process (GO:0034250)2.41767136
163regulation of mast cell activation (GO:0033003)2.41607158
164regulation of dendritic cell antigen processing and presentation (GO:0002604)2.41092735
165regulation of interleukin-1 beta secretion (GO:0050706)2.41027273
166poly(A)+ mRNA export from nucleus (GO:0016973)2.39013489
167energy homeostasis (GO:0097009)2.38443626
168modulation by symbiont of host cellular process (GO:0044068)2.37768839
169regulation of mast cell activation involved in immune response (GO:0033006)2.37539169
170glycolipid catabolic process (GO:0019377)2.37431590
171positive regulation of icosanoid secretion (GO:0032305)2.36878474
172positive regulation of mast cell degranulation (GO:0043306)2.36811333
173positive regulation of mast cell activation involved in immune response (GO:0033008)2.36811333
174negative regulation of DNA-dependent DNA replication (GO:2000104)2.36226775
175microtubule depolymerization (GO:0007019)2.36220312
176natural killer cell activation involved in immune response (GO:0002323)2.35993332
177import into cell (GO:0098657)2.32696899
178positive regulation of cell fate commitment (GO:0010455)2.30809325
179protein heterotetramerization (GO:0051290)2.30671110
180negative regulation of keratinocyte proliferation (GO:0010839)2.30501526
181response to host immune response (GO:0052572)2.30278484
182response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.30278484
183androgen biosynthetic process (GO:0006702)2.29759030
184mannosylation (GO:0097502)2.27050777
185regulation of translation, ncRNA-mediated (GO:0045974)2.26929625
186negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.26929625
187negative regulation of translation, ncRNA-mediated (GO:0040033)2.26929625
188negative regulation of myoblast differentiation (GO:0045662)2.26896767
189photoreceptor cell maintenance (GO:0045494)2.26346400
190respiratory burst (GO:0045730)2.26021833
191DNA ligation (GO:0006266)2.25687701
192microglial cell activation (GO:0001774)2.25525759
193regulation of antigen processing and presentation (GO:0002577)2.25143425
194presynaptic membrane organization (GO:0097090)2.24735616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.60389631
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.34717535
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.20779923
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.16742385
5GBX2_23144817_ChIP-Seq_PC3_Human3.10571277
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.91231074
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.68610758
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63008642
9SUZ12_27294783_Chip-Seq_NPCs_Mouse2.44599317
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.42234859
11PCGF2_27294783_Chip-Seq_NPCs_Mouse2.41292165
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36440909
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30282336
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26708474
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23839312
16NFE2_27457419_Chip-Seq_LIVER_Mouse2.22058545
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.21543006
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16508383
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10113149
20EZH2_27294783_Chip-Seq_NPCs_Mouse2.08818320
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98696646
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97714269
23EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.94895239
24SUZ12_18555785_Chip-Seq_ESCs_Mouse1.92619943
25STAT3_18555785_Chip-Seq_ESCs_Mouse1.89917361
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.87863374
27P53_22387025_ChIP-Seq_ESCs_Mouse1.84686868
28IRF1_19129219_ChIP-ChIP_H3396_Human1.82747728
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.82501627
30VDR_22108803_ChIP-Seq_LS180_Human1.82358004
31NMYC_18555785_Chip-Seq_ESCs_Mouse1.80684831
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80234892
33EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.80019462
34RUNX1_27457419_Chip-Seq_LIVER_Mouse1.79212522
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79155143
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.76819886
37P300_18555785_Chip-Seq_ESCs_Mouse1.76403941
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.73354279
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.70216912
40OCT4_18555785_Chip-Seq_ESCs_Mouse1.69216645
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.67480676
42CMYC_18555785_Chip-Seq_ESCs_Mouse1.66471401
43TAF15_26573619_Chip-Seq_HEK293_Human1.65563782
44ZFX_18555785_Chip-Seq_ESCs_Mouse1.63976081
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60536943
46KLF4_18555785_Chip-Seq_ESCs_Mouse1.60356297
47* GABP_17652178_ChIP-ChIP_JURKAT_Human1.60000297
48STAT3_23295773_ChIP-Seq_U87_Human1.58521182
49SMAD4_21799915_ChIP-Seq_A2780_Human1.58493573
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.58222851
51SMAD1_18555785_Chip-Seq_ESCs_Mouse1.58089654
52PU1_27457419_Chip-Seq_LIVER_Mouse1.58025601
53ESRRB_18555785_Chip-Seq_ESCs_Mouse1.56766947
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56228705
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56181417
56CBP_20019798_ChIP-Seq_JUKART_Human1.56181417
57ER_23166858_ChIP-Seq_MCF-7_Human1.55969285
58SOX2_18555785_Chip-Seq_ESCs_Mouse1.54782936
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.54133003
60* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52182672
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50957128
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.50465618
63IGF1R_20145208_ChIP-Seq_DFB_Human1.50068511
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.48933863
65BCAT_22108803_ChIP-Seq_LS180_Human1.47694747
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.46518612
67AR_25329375_ChIP-Seq_VCAP_Human1.45812926
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45724869
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44733293
70ELK1_19687146_ChIP-ChIP_HELA_Human1.44697112
71RNF2_27304074_Chip-Seq_NSC_Mouse1.44483994
72P300_19829295_ChIP-Seq_ESCs_Human1.44127027
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43557736
74CTCF_18555785_Chip-Seq_ESCs_Mouse1.42693795
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42644154
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42466294
77* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42080174
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.41337572
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.41087881
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40208239
81MYC_18940864_ChIP-ChIP_HL60_Human1.36355328
82FUS_26573619_Chip-Seq_HEK293_Human1.36019102
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35988076
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.35504139
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35028160
86NANOG_19829295_ChIP-Seq_ESCs_Human1.34784918
87SOX2_19829295_ChIP-Seq_ESCs_Human1.34784918
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34731347
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34731347
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34586984
91TP53_22573176_ChIP-Seq_HFKS_Human1.34255354
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32483382
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.32234432
94TCF4_22108803_ChIP-Seq_LS180_Human1.32061534
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31596081
96* IRF8_27001747_Chip-Seq_BMDM_Mouse1.30328851
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28666500
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28342325
99EWS_26573619_Chip-Seq_HEK293_Human1.26545442
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25965945
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24911700
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23327809
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22650356
104RUNX2_22187159_ChIP-Seq_PCA_Human1.22184069
105EZH2_22144423_ChIP-Seq_EOC_Human1.19597564
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17956060
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.17956060
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17928412
109VDR_23849224_ChIP-Seq_CD4+_Human1.17876899
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17797528
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.16969605
112* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16834595
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14728317
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.13587508
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.12554338
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10762030
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10578220
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10189868
119KDM2B_26808549_Chip-Seq_REH_Human1.10082930
120CDX2_22108803_ChIP-Seq_LS180_Human1.09652351
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09345323
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08577666
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07223156
124* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06866817
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05649815
126SCL_19346495_ChIP-Seq_HPC-7_Human1.05593537
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04772801
128KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03810452
129NCOR_22424771_ChIP-Seq_293T_Human1.03285235
130AR_20517297_ChIP-Seq_VCAP_Human1.01991531
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01812424
132ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00326482
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99440709
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99170623
135JUN_21703547_ChIP-Seq_K562_Human0.98807884
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98671898
137CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97278928
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97128807
139WT1_19549856_ChIP-ChIP_CCG9911_Human0.94020130
140STAT1_17558387_ChIP-Seq_HELA_Human0.93653008
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93588043
142PHF8_20622853_ChIP-Seq_HELA_Human0.91241932
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90674742
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89753353
145AR_21572438_ChIP-Seq_LNCaP_Human0.89751958
146* TCF4_23295773_ChIP-Seq_U87_Human0.89087045
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88212291
148SMAD3_21741376_ChIP-Seq_EPCs_Human0.87562907
149STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87286733
150EED_16625203_ChIP-ChIP_MESCs_Mouse0.87032880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.37118360
2MP0001188_hyperpigmentation3.11439234
3MP0002102_abnormal_ear_morphology2.88931589
4MP0002277_abnormal_respiratory_mucosa2.83807532
5MP0005645_abnormal_hypothalamus_physiol2.52684837
6MP0004381_abnormal_hair_follicle2.52613531
7MP0002138_abnormal_hepatobiliary_system2.51179768
8MP0000015_abnormal_ear_pigmentation2.45243977
9MP0001835_abnormal_antigen_presentation2.29731695
10MP0003136_yellow_coat_color2.29696211
11MP0005551_abnormal_eye_electrophysiolog2.24747758
12MP0002148_abnormal_hypersensitivity_rea2.24406687
13MP0001986_abnormal_taste_sensitivity2.22527004
14MP0003646_muscle_fatigue2.13887035
15MP0002837_dystrophic_cardiac_calcinosis2.13651558
16MP0005451_abnormal_body_composition2.08351270
17MP0010386_abnormal_urinary_bladder2.02642955
18MP0002736_abnormal_nociception_after2.02299522
19MP0005379_endocrine/exocrine_gland_phen2.01951299
20MP0005387_immune_system_phenotype1.99603366
21MP0001790_abnormal_immune_system1.99603366
22MP0001968_abnormal_touch/_nociception1.98497585
23MP0005409_darkened_coat_color1.93496616
24MP0002653_abnormal_ependyma_morphology1.92583593
25MP0005174_abnormal_tail_pigmentation1.90250645
26MP0000566_synostosis1.84510045
27MP0004147_increased_porphyrin_level1.82897709
28MP0008260_abnormal_autophagy1.80488206
29MP0001984_abnormal_olfaction1.76279275
30MP0001529_abnormal_vocalization1.76237652
31MP0002419_abnormal_innate_immunity1.75481141
32MP0003195_calcinosis1.74956546
33MP0000427_abnormal_hair_cycle1.71501291
34MP0003718_maternal_effect1.68079905
35MP0005000_abnormal_immune_tolerance1.65785632
36MP0009785_altered_susceptibility_to1.65759687
37MP0002132_abnormal_respiratory_system1.65642437
38MP0009046_muscle_twitch1.64289945
39MP0003436_decreased_susceptibility_to1.62417901
40MP0005310_abnormal_salivary_gland1.62357214
41MP0004742_abnormal_vestibular_system1.61378605
42MP0006276_abnormal_autonomic_nervous1.60340240
43MP0005671_abnormal_response_to1.59719696
44MP0002876_abnormal_thyroid_physiology1.58982645
45MP0000631_abnormal_neuroendocrine_gland1.57448244
46MP0005075_abnormal_melanosome_morpholog1.57364430
47MP0009745_abnormal_behavioral_response1.55528531
48MP0002723_abnormal_immune_serum1.54820338
49MP0004043_abnormal_pH_regulation1.54620000
50MP0005171_absent_coat_pigmentation1.53684210
51MP0003787_abnormal_imprinting1.52274980
52MP0003724_increased_susceptibility_to1.50824356
53MP0008875_abnormal_xenobiotic_pharmacok1.49332153
54MP0002452_abnormal_antigen_presenting1.49007786
55MP0002735_abnormal_chemical_nociception1.48351450
56MP0000383_abnormal_hair_follicle1.47980951
57MP0001800_abnormal_humoral_immune1.46446794
58MP0003880_abnormal_central_pattern1.46249938
59MP0003011_delayed_dark_adaptation1.44519738
60MP0008058_abnormal_DNA_repair1.44370211
61MP0004885_abnormal_endolymph1.39832994
62MP0002234_abnormal_pharynx_morphology1.39383353
63MP0005025_abnormal_response_to1.38919494
64MP0009764_decreased_sensitivity_to1.35685907
65MP0008872_abnormal_physiological_respon1.32724500
66MP0005389_reproductive_system_phenotype1.32309580
67MP0002272_abnormal_nervous_system1.32210856
68MP0002160_abnormal_reproductive_system1.30887988
69MP0008057_abnormal_DNA_replication1.30546512
70MP0000685_abnormal_immune_system1.28190656
71MP0001501_abnormal_sleep_pattern1.28130376
72MP0001819_abnormal_immune_cell1.27197213
73MP0002420_abnormal_adaptive_immunity1.26936604
74MP0008877_abnormal_DNA_methylation1.26355232
75MP0000613_abnormal_salivary_gland1.26185463
76MP0002638_abnormal_pupillary_reflex1.25180340
77MP0001485_abnormal_pinna_reflex1.24785313
78MP0002163_abnormal_gland_morphology1.24672535
79MP0002933_joint_inflammation1.22365166
80MP0001486_abnormal_startle_reflex1.21122737
81MP0002405_respiratory_system_inflammati1.20184345
82MP0001919_abnormal_reproductive_system1.19753281
83MP0000569_abnormal_digit_pigmentation1.19277086
84MP0006082_CNS_inflammation1.18145276
85MP0002095_abnormal_skin_pigmentation1.16720276
86MP0003121_genomic_imprinting1.15773594
87MP0004215_abnormal_myocardial_fiber1.14518758
88MP0008995_early_reproductive_senescence1.13924922
89MP0003941_abnormal_skin_development1.12357269
90MP0000470_abnormal_stomach_morphology1.11914189
91MP0008789_abnormal_olfactory_epithelium1.11620146
92MP0000678_abnormal_parathyroid_gland1.10828681
93MP0002572_abnormal_emotion/affect_behav1.10806997
94MP0002009_preneoplasia1.10543677
95MP0004145_abnormal_muscle_electrophysio1.10222033
96MP0005386_behavior/neurological_phenoty1.10071059
97MP0004924_abnormal_behavior1.10071059
98MP0003890_abnormal_embryonic-extraembry1.09698385
99MP0000647_abnormal_sebaceous_gland1.08562303
100MP0000372_irregular_coat_pigmentation1.05237351
101MP0003567_abnormal_fetal_cardiomyocyte1.04928460
102MP0002557_abnormal_social/conspecific_i1.03665035
103MP0005646_abnormal_pituitary_gland1.02813618
104MP0002938_white_spotting1.01769945
105MP0002098_abnormal_vibrissa_morphology1.01622258
106MP0001293_anophthalmia1.01420970
107MP0003763_abnormal_thymus_physiology1.00964644
108MP0002177_abnormal_outer_ear0.99407994
109MP0003698_abnormal_male_reproductive0.99167697
110MP0005187_abnormal_penis_morphology0.99167295
111MP0004019_abnormal_vitamin_homeostasis0.98378017
112MP0001929_abnormal_gametogenesis0.97630375
113MP0000490_abnormal_crypts_of0.97139493
114MP0005195_abnormal_posterior_eye0.96624196
115MP0002067_abnormal_sensory_capabilities0.95934493
116MP0003283_abnormal_digestive_organ0.95897120
117MP0000716_abnormal_immune_system0.95357357
118MP0005410_abnormal_fertilization0.95229985
119MP0002064_seizures0.94237789
120MP0000465_gastrointestinal_hemorrhage0.93724218
121MP0002734_abnormal_mechanical_nocicepti0.91787918
122MP0001970_abnormal_pain_threshold0.90272688
123MP0005408_hypopigmentation0.90084739
124MP0009697_abnormal_copulation0.89947478
125MP0000026_abnormal_inner_ear0.89448958
126MP0002751_abnormal_autonomic_nervous0.88277786
127MP0000920_abnormal_myelination0.87808419
128MP0001905_abnormal_dopamine_level0.87429091
129MP0009379_abnormal_foot_pigmentation0.87195871
130MP0003937_abnormal_limbs/digits/tail_de0.86163328
131MP0002210_abnormal_sex_determination0.85699979
132MP0001324_abnormal_eye_pigmentation0.85666025
133MP0000778_abnormal_nervous_system0.84131106
134MP0004142_abnormal_muscle_tone0.84082043
135MP0010155_abnormal_intestine_physiology0.83963138
136MP0003252_abnormal_bile_duct0.83844391
137MP0005085_abnormal_gallbladder_physiolo0.83418938
138MP0001346_abnormal_lacrimal_gland0.82888610
139MP0002733_abnormal_thermal_nociception0.82383435
140MP0001845_abnormal_inflammatory_respons0.82029815
141MP0005367_renal/urinary_system_phenotyp0.81133045
142MP0000516_abnormal_urinary_system0.81133045
143MP0006035_abnormal_mitochondrial_morpho0.80395025
144MP0005084_abnormal_gallbladder_morpholo0.80209200
145MP0002693_abnormal_pancreas_physiology0.80070673
146MP0000653_abnormal_sex_gland0.79670932
147MP0002254_reproductive_system_inflammat0.79497633
148MP0002063_abnormal_learning/memory/cond0.79006406
149MP0000538_abnormal_urinary_bladder0.78983129
150MP0003183_abnormal_peptide_metabolism0.78435110
151MP0005058_abnormal_lysosome_morphology0.77960480
152MP0004133_heterotaxia0.77900525
153MP0001873_stomach_inflammation0.77588317
154MP0001764_abnormal_homeostasis0.77541244
155MP0004085_abnormal_heartbeat0.76866458
156MP0005253_abnormal_eye_physiology0.76633774
157MP0010678_abnormal_skin_adnexa0.76606596
158MP0005167_abnormal_blood-brain_barrier0.76544135
159MP0003938_abnormal_ear_development0.75961733
160MP0005647_abnormal_sex_gland0.75767100
161MP0005464_abnormal_platelet_physiology0.73251580
162MP0002398_abnormal_bone_marrow0.72945336
163MP0001186_pigmentation_phenotype0.72732667
164MP0000681_abnormal_thyroid_gland0.70534514
165MP0001963_abnormal_hearing_physiology0.70124776
166MP0002928_abnormal_bile_duct0.69778828
167MP0006072_abnormal_retinal_apoptosis0.69743270

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.68592060
2Molar tooth sign on MRI (HP:0002419)4.31757010
3Abnormality of midbrain morphology (HP:0002418)4.31757010
4Chromsome breakage (HP:0040012)4.21752825
5Duplicated collecting system (HP:0000081)3.96682967
6Nephronophthisis (HP:0000090)3.73437799
7Abnormality of the renal collecting system (HP:0004742)3.69922392
8Anomalous pulmonary venous return (HP:0010772)3.04491192
9Hyperventilation (HP:0002883)3.01988726
10Congenital stationary night blindness (HP:0007642)2.99794519
11Abnormality of DNA repair (HP:0003254)2.80795054
12Renal cortical cysts (HP:0000803)2.77685318
13Gait imbalance (HP:0002141)2.76710380
14Prostate neoplasm (HP:0100787)2.75302064
15Stomatitis (HP:0010280)2.74060945
16Congenital primary aphakia (HP:0007707)2.72958242
17Recurrent abscess formation (HP:0002722)2.71258748
18Optic neuritis (HP:0100653)2.71079598
19Retrobulbar optic neuritis (HP:0100654)2.71079598
20Cystic liver disease (HP:0006706)2.67764972
21Nephrogenic diabetes insipidus (HP:0009806)2.65076742
22Abnormality of the pulmonary veins (HP:0011718)2.54151357
23Large for gestational age (HP:0001520)2.53367635
24Septo-optic dysplasia (HP:0100842)2.52155429
25Polydipsia (HP:0001959)2.51520714
26Abnormal drinking behavior (HP:0030082)2.51520714
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.51015080
28Tubular atrophy (HP:0000092)2.50745092
29Absent/shortened dynein arms (HP:0200106)2.48715767
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.48715767
31Congenital sensorineural hearing impairment (HP:0008527)2.47717034
32True hermaphroditism (HP:0010459)2.43923997
33Abolished electroretinogram (ERG) (HP:0000550)2.43899157
34Abnormality of the labia minora (HP:0012880)2.43745545
35Sclerocornea (HP:0000647)2.41365817
36Osteomalacia (HP:0002749)2.41156281
37Duplication of thumb phalanx (HP:0009942)2.40667564
38Protruding tongue (HP:0010808)2.38227951
39Gaze-evoked nystagmus (HP:0000640)2.38125080
40Type II lissencephaly (HP:0007260)2.38023671
41Postaxial foot polydactyly (HP:0001830)2.37243303
42Reduced antithrombin III activity (HP:0001976)2.36470949
43Recurrent bacterial skin infections (HP:0005406)2.36268774
44Parakeratosis (HP:0001036)2.36056317
45Intestinal atresia (HP:0011100)2.36022216
46Abnormal rod and cone electroretinograms (HP:0008323)2.35673172
47Bile duct proliferation (HP:0001408)2.33619342
48Abnormal biliary tract physiology (HP:0012439)2.33619342
49Furrowed tongue (HP:0000221)2.33460607
50Genital tract atresia (HP:0001827)2.32859239
51Inability to walk (HP:0002540)2.30632522
52Pendular nystagmus (HP:0012043)2.30043976
53Anencephaly (HP:0002323)2.29246095
54Pancreatic fibrosis (HP:0100732)2.27145897
55Type I transferrin isoform profile (HP:0003642)2.27135933
56Abnormality of alanine metabolism (HP:0010916)2.26128111
57Hyperalaninemia (HP:0003348)2.26128111
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26128111
59Chronic obstructive pulmonary disease (HP:0006510)2.24181943
60Obstructive lung disease (HP:0006536)2.24181943
61Progressive inability to walk (HP:0002505)2.21168958
62Vaginal atresia (HP:0000148)2.20042357
63Patchy hypopigmentation of hair (HP:0011365)2.19520384
64Hypothermia (HP:0002045)2.17928061
65Abnormal ciliary motility (HP:0012262)2.17748458
66Abnormal respiratory epithelium morphology (HP:0012253)2.17105823
67Abnormal respiratory motile cilium morphology (HP:0005938)2.17105823
68Methylmalonic acidemia (HP:0002912)2.16686988
69Abnormal hair whorl (HP:0010721)2.15926275
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.13578947
71Chronic hepatic failure (HP:0100626)2.13236373
72Abnormality of the preputium (HP:0100587)2.12393184
73Optic nerve hypoplasia (HP:0000609)2.11848472
74Increased corneal curvature (HP:0100692)2.10855013
75Keratoconus (HP:0000563)2.10855013
76Abnormality of incisor morphology (HP:0011063)2.10669384
77White forelock (HP:0002211)2.09176095
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09106465
79Fair hair (HP:0002286)2.08481680
80Conjugated hyperbilirubinemia (HP:0002908)2.07909336
81Vacuolated lymphocytes (HP:0001922)2.07639184
82Alveolar cell carcinoma (HP:0006519)2.04434713
83Oligodactyly (hands) (HP:0001180)2.03443920
84Hypophosphatemic rickets (HP:0004912)2.03115825
85Recurrent pneumonia (HP:0006532)2.03059801
86Submucous cleft hard palate (HP:0000176)2.02127802
87Postaxial hand polydactyly (HP:0001162)2.01450513
88Hypergonadotropic hypogonadism (HP:0000815)2.00509050
89Poor coordination (HP:0002370)2.00497220
90Ectopic kidney (HP:0000086)1.99755088
91Ketoacidosis (HP:0001993)1.98568519
92Polyuria (HP:0000103)1.96985143
93Lissencephaly (HP:0001339)1.96557650
94Hypoplasia of the fovea (HP:0007750)1.96311811
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.96311811
96Increased CSF lactate (HP:0002490)1.96218830
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.95939153
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95727712
99Acute necrotizing encephalopathy (HP:0006965)1.95597858
100Reticulocytopenia (HP:0001896)1.95473958
101Pancreatic cysts (HP:0001737)1.94769478
102Clubbing of toes (HP:0100760)1.94475875
103Abnormality of the renal cortex (HP:0011035)1.94056928
104Tubulointerstitial nephritis (HP:0001970)1.92384274
105Progressive cerebellar ataxia (HP:0002073)1.91553222
106Decreased central vision (HP:0007663)1.90698381
107Eczematoid dermatitis (HP:0000976)1.90454339
108Elevated erythrocyte sedimentation rate (HP:0003565)1.89968058
109Broad-based gait (HP:0002136)1.89641733
110Abnormal delayed hypersensitivity skin test (HP:0002963)1.87251891
111Febrile seizures (HP:0002373)1.86583644
112Progressive macrocephaly (HP:0004481)1.85979881
113Patellar aplasia (HP:0006443)1.85646070
114Mitochondrial inheritance (HP:0001427)1.84190938
115Renal Fanconi syndrome (HP:0001994)1.82660306
116Stomach cancer (HP:0012126)1.80501121
117Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80164939
118Hyperglycinuria (HP:0003108)1.80130415
119Abnormal protein N-linked glycosylation (HP:0012347)1.79808655
120Abnormal protein glycosylation (HP:0012346)1.79808655
121Abnormal glycosylation (HP:0012345)1.79808655
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79808655
123Methylmalonic aciduria (HP:0012120)1.78961681
124Orchitis (HP:0100796)1.78585044
125Aplasia/Hypoplasia of the patella (HP:0006498)1.77559147
126Cerebellar dysplasia (HP:0007033)1.77455090
127Bony spicule pigmentary retinopathy (HP:0007737)1.77167219
128Meningitis (HP:0001287)1.76947444
129Asplenia (HP:0001746)1.76883303
130Recurrent skin infections (HP:0001581)1.76305420
131Joint hemorrhage (HP:0005261)1.75953596
132Ketosis (HP:0001946)1.75833890
133Upper limb muscle weakness (HP:0003484)1.75792467
1343-Methylglutaconic aciduria (HP:0003535)1.75704625
135Encephalitis (HP:0002383)1.75654260
136Sloping forehead (HP:0000340)1.75455948
137Prolonged neonatal jaundice (HP:0006579)1.74923022
138Congenital hepatic fibrosis (HP:0002612)1.74691173
139Male pseudohermaphroditism (HP:0000037)1.74376606
140Chorioretinal atrophy (HP:0000533)1.73665639
141Abnormality of renal resorption (HP:0011038)1.73352997
142Genetic anticipation (HP:0003743)1.73154226
143Occipital encephalocele (HP:0002085)1.72925689
144Narrow forehead (HP:0000341)1.71664708
145Disproportionate short-trunk short stature (HP:0003521)1.71624682
146Absent speech (HP:0001344)1.71596314
147Meckel diverticulum (HP:0002245)1.71458113
148Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71447528
149Acute encephalopathy (HP:0006846)1.71431388
150Bone marrow hypocellularity (HP:0005528)1.70664074
151Medial flaring of the eyebrow (HP:0010747)1.70007318
152Generalized hypopigmentation of hair (HP:0011358)1.69419398
153Dandy-Walker malformation (HP:0001305)1.69003850
154Abnormality of chromosome stability (HP:0003220)1.68454048
155Neoplasm of the tracheobronchial system (HP:0100552)1.68377671
156Concave nail (HP:0001598)1.68185011
157Abnormality of the renal medulla (HP:0100957)1.68183882
158Hepatic necrosis (HP:0002605)1.68170889
159Abnormality of the prostate (HP:0008775)1.67590622
160Cheilitis (HP:0100825)1.66850574
161Abnormal respiratory motile cilium physiology (HP:0012261)1.65078857
162Chronic diarrhea (HP:0002028)1.64994171
163Preaxial hand polydactyly (HP:0001177)1.64653328
164Abnormality of the ileum (HP:0001549)1.64344732
165Mediastinal lymphadenopathy (HP:0100721)1.64114909
166Chronic mucocutaneous candidiasis (HP:0002728)1.62281088
167Recurrent cutaneous fungal infections (HP:0011370)1.62281088
168Myositis (HP:0100614)1.61971341
169Oligohydramnios (HP:0001562)1.61662100
170Attenuation of retinal blood vessels (HP:0007843)1.60904846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.51389876
2IRAK43.20247478
3BRD43.15857187
4STK163.06159538
5MAP4K23.03878742
6MKNK23.01436592
7MAP3K142.82101999
8CASK2.66843352
9PINK12.58643527
10ZAK2.51803480
11ACVR1B2.36096418
12PIK3CG2.33662211
13NUAK12.29896792
14BMPR1B2.27895304
15BLK2.25096360
16TXK2.14000730
17MKNK12.11128784
18TNIK2.10276101
19NEK62.08106742
20TAOK32.05765849
21TRIM281.90130230
22PNCK1.67517503
23TEC1.61349732
24INSRR1.60245822
25EIF2AK21.59638576
26MAPK151.58292416
27MAP3K41.51392355
28BMPR21.49365821
29STK38L1.45144959
30YES11.40342737
31IKBKB1.37941129
32GRK11.26431574
33IRAK21.26429587
34IRAK11.21750698
35GRK71.20595531
36SIK31.18512495
37ADRBK21.18031576
38CDK121.17612820
39PLK21.15923589
40PKN11.14156953
41BRSK21.09009138
42MARK11.04879987
43TNK21.04682782
44CDK31.03589474
45PAK31.03571035
46DAPK21.02837324
47SRPK11.01909833
48IKBKE1.01194036
49FGR0.99462589
50MST40.97799292
51CHUK0.94993917
52BTK0.94814304
53CAMKK20.93818713
54ADRBK10.92865027
55CCNB10.92507156
56WEE10.91480030
57CLK10.90853892
58STK390.89421477
59TRPM70.89190291
60FGFR20.86667477
61PLK30.86567832
62VRK10.84069503
63MAP4K10.83172181
64MAP3K130.80124299
65PRKCG0.79424952
66EIF2AK30.77980838
67OXSR10.77261043
68PBK0.74201361
69MAPKAPK30.72525838
70MAP2K70.72485989
71PRPF4B0.72426403
72NLK0.72319884
73MET0.71074330
74DYRK30.71035054
75OBSCN0.70896262
76PHKG10.68572592
77PHKG20.68572592
78TSSK60.68347679
79STK30.68161196
80MAPK130.67803324
81LYN0.67780174
82CSF1R0.67657620
83PLK40.67405676
84CSNK1G20.66768335
85TGFBR10.65502028
86NTRK30.65215560
87RPS6KA50.64465128
88AKT30.63794871
89DYRK20.63734408
90ITK0.63204777
91TLK10.62858628
92HIPK20.62442908
93BCR0.61981495
94ERBB30.61271464
95STK240.60925574
96STK40.60626905
97ERBB40.59676614
98WNK30.59568301
99KIT0.59451440
100CSNK1A1L0.59047659
101LCK0.57152136
102MAP2K60.57134880
103NME20.56328048
104PTK2B0.54820787
105PRKCQ0.54411618
106JAK30.53464027
107CDK70.51675064
108TYK20.50591251
109CDK90.50324228
110WNK40.50205627
111PIK3CA0.49698713
112PIM10.49686892
113MAPKAPK50.49625624
114STK110.48608996
115PRKCE0.48381932
116CAMK2A0.47142450
117NTRK20.46707716
118DYRK1A0.45433252
119TGFBR20.44327406
120FES0.42964729
121BCKDK0.42395703
122FRK0.41680149
123ZAP700.41155839
124PLK10.40991109
125CSK0.40571055
126PRKCI0.40222653
127ATR0.38976747
128PRKACA0.38475302
129CHEK20.38368542
130ATM0.37504561
131SYK0.36727618
132SGK20.36621802
133PASK0.35449246
134PRKG10.35165861
135PRKAA10.34954503
136HCK0.34804761
137CAMK10.34601499
138WNK10.33344210
139CSNK1A10.32979056
140ABL10.32161732
141EPHA30.31105732
142CSNK1G10.30309258
143CAMK2B0.29433713
144FER0.27933103
145PRKAA20.27635115
146CSNK1G30.25448788
147MUSK0.24406191
148TTK0.24039551
149MAPK30.23658147
150SGK2230.23510549

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006502.57119732
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40914748
3Protein export_Homo sapiens_hsa030602.36398943
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35623386
5Fanconi anemia pathway_Homo sapiens_hsa034602.33720825
6Other glycan degradation_Homo sapiens_hsa005112.30842792
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.21777599
8Selenocompound metabolism_Homo sapiens_hsa004502.18317988
9Nitrogen metabolism_Homo sapiens_hsa009102.14281513
10Oxidative phosphorylation_Homo sapiens_hsa001902.13336337
11Non-homologous end-joining_Homo sapiens_hsa034502.09841955
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.07468716
13Propanoate metabolism_Homo sapiens_hsa006401.98925158
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.97158668
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94391536
16Tryptophan metabolism_Homo sapiens_hsa003801.94191821
17Sphingolipid metabolism_Homo sapiens_hsa006001.92935294
18Nicotine addiction_Homo sapiens_hsa050331.86388513
19Sulfur metabolism_Homo sapiens_hsa009201.83493846
20Autoimmune thyroid disease_Homo sapiens_hsa053201.81283161
21Arachidonic acid metabolism_Homo sapiens_hsa005901.78542390
22Caffeine metabolism_Homo sapiens_hsa002321.70478448
23Linoleic acid metabolism_Homo sapiens_hsa005911.69777438
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67100968
25Allograft rejection_Homo sapiens_hsa053301.66688118
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65865502
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.61433949
28Parkinsons disease_Homo sapiens_hsa050121.61103650
29Primary immunodeficiency_Homo sapiens_hsa053401.61101430
30Ether lipid metabolism_Homo sapiens_hsa005651.58461237
31Graft-versus-host disease_Homo sapiens_hsa053321.53669977
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53243155
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52438198
34Steroid biosynthesis_Homo sapiens_hsa001001.52083208
35Basal transcription factors_Homo sapiens_hsa030221.51342516
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50832628
37Asthma_Homo sapiens_hsa053101.49135965
38Homologous recombination_Homo sapiens_hsa034401.47464350
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44700955
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38730087
41Hematopoietic cell lineage_Homo sapiens_hsa046401.36961670
42RNA polymerase_Homo sapiens_hsa030201.36849589
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.33583659
44Histidine metabolism_Homo sapiens_hsa003401.29317766
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28836566
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28576381
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28248319
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26753671
49Olfactory transduction_Homo sapiens_hsa047401.25000288
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24971935
51Measles_Homo sapiens_hsa051621.24515790
52Fatty acid elongation_Homo sapiens_hsa000621.23864442
53Peroxisome_Homo sapiens_hsa041461.23763366
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.20407938
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19023833
56Retinol metabolism_Homo sapiens_hsa008301.18116788
57Rheumatoid arthritis_Homo sapiens_hsa053231.18100388
58Staphylococcus aureus infection_Homo sapiens_hsa051501.16687965
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14811960
60Huntingtons disease_Homo sapiens_hsa050161.14785859
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14540008
62Malaria_Homo sapiens_hsa051441.06564430
63Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06328075
64Vitamin digestion and absorption_Homo sapiens_hsa049771.04541278
65One carbon pool by folate_Homo sapiens_hsa006701.04214488
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03422132
67Folate biosynthesis_Homo sapiens_hsa007901.01853279
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01118890
69ABC transporters_Homo sapiens_hsa020101.01053724
70Leishmaniasis_Homo sapiens_hsa051400.98438407
71Morphine addiction_Homo sapiens_hsa050320.98145329
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94182693
73Mismatch repair_Homo sapiens_hsa034300.93768703
74Regulation of autophagy_Homo sapiens_hsa041400.93445110
75Insulin secretion_Homo sapiens_hsa049110.90968166
76Alzheimers disease_Homo sapiens_hsa050100.90840469
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90728953
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90608587
79Phototransduction_Homo sapiens_hsa047440.90332712
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90094618
81Herpes simplex infection_Homo sapiens_hsa051680.89184483
82Osteoclast differentiation_Homo sapiens_hsa043800.85161275
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82831031
84Pyrimidine metabolism_Homo sapiens_hsa002400.80486696
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78633490
86GABAergic synapse_Homo sapiens_hsa047270.75908311
87Collecting duct acid secretion_Homo sapiens_hsa049660.75823687
88Lysosome_Homo sapiens_hsa041420.75582107
89Cardiac muscle contraction_Homo sapiens_hsa042600.74694096
90Mineral absorption_Homo sapiens_hsa049780.74484242
91Circadian entrainment_Homo sapiens_hsa047130.71648835
92Fatty acid degradation_Homo sapiens_hsa000710.71473560
93Ovarian steroidogenesis_Homo sapiens_hsa049130.70998273
94Glutamatergic synapse_Homo sapiens_hsa047240.70163859
95Proteasome_Homo sapiens_hsa030500.69876858
96p53 signaling pathway_Homo sapiens_hsa041150.69841964
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69649761
98Chemical carcinogenesis_Homo sapiens_hsa052040.69146755
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.68448224
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67941294
101Phagosome_Homo sapiens_hsa041450.67587655
102Vitamin B6 metabolism_Homo sapiens_hsa007500.66888752
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66887513
104beta-Alanine metabolism_Homo sapiens_hsa004100.66361403
105Fatty acid metabolism_Homo sapiens_hsa012120.64851042
106Purine metabolism_Homo sapiens_hsa002300.64096952
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.64075080
108RNA transport_Homo sapiens_hsa030130.63720800
109Base excision repair_Homo sapiens_hsa034100.63685616
110Nucleotide excision repair_Homo sapiens_hsa034200.62842840
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62621635
112RNA degradation_Homo sapiens_hsa030180.59876133
113TNF signaling pathway_Homo sapiens_hsa046680.58986929
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57511871
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56550823
116Glycerolipid metabolism_Homo sapiens_hsa005610.56516364
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56390481
118Pertussis_Homo sapiens_hsa051330.55720561
119Salivary secretion_Homo sapiens_hsa049700.55405828
120Ribosome_Homo sapiens_hsa030100.54089669
121Dorso-ventral axis formation_Homo sapiens_hsa043200.53750345
122B cell receptor signaling pathway_Homo sapiens_hsa046620.52884308
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52580885
124Tyrosine metabolism_Homo sapiens_hsa003500.50967440
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49880097
126Taste transduction_Homo sapiens_hsa047420.49012935
127Influenza A_Homo sapiens_hsa051640.47760624
128T cell receptor signaling pathway_Homo sapiens_hsa046600.47540228
129Calcium signaling pathway_Homo sapiens_hsa040200.46402653
130Hedgehog signaling pathway_Homo sapiens_hsa043400.45150023
131Apoptosis_Homo sapiens_hsa042100.45130273
132Arginine and proline metabolism_Homo sapiens_hsa003300.44772907
133Dopaminergic synapse_Homo sapiens_hsa047280.44021211
134Phenylalanine metabolism_Homo sapiens_hsa003600.43466705
135Chemokine signaling pathway_Homo sapiens_hsa040620.43372613
136Fat digestion and absorption_Homo sapiens_hsa049750.42829455
137Lysine degradation_Homo sapiens_hsa003100.42458420
138Type I diabetes mellitus_Homo sapiens_hsa049400.42099650
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41998129
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40720471
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40140496
142DNA replication_Homo sapiens_hsa030300.39469970
143Serotonergic synapse_Homo sapiens_hsa047260.37676815
144African trypanosomiasis_Homo sapiens_hsa051430.37031114
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36446861
146Circadian rhythm_Homo sapiens_hsa047100.35971903
147Metabolic pathways_Homo sapiens_hsa011000.35133122
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.34490146
149Amphetamine addiction_Homo sapiens_hsa050310.34424603
150Tuberculosis_Homo sapiens_hsa051520.34106158
151TGF-beta signaling pathway_Homo sapiens_hsa043500.33038696
152Long-term depression_Homo sapiens_hsa047300.32004913

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