THAP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.29636381
2ribosomal small subunit assembly (GO:0000028)5.39692463
3regulation of mitochondrial translation (GO:0070129)4.41867858
4viral transcription (GO:0019083)4.16594136
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.15297080
6proteasome assembly (GO:0043248)4.07802684
7translational termination (GO:0006415)4.03864934
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01134791
9cotranslational protein targeting to membrane (GO:0006613)3.92072960
10nucleotide salvage (GO:0043173)3.92017950
11protein targeting to ER (GO:0045047)3.89772514
12ribosomal small subunit biogenesis (GO:0042274)3.85754425
13DNA strand elongation involved in DNA replication (GO:0006271)3.83118940
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.77178197
15proline biosynthetic process (GO:0006561)3.76595728
16protein localization to endoplasmic reticulum (GO:0070972)3.75202939
17telomere maintenance via semi-conservative replication (GO:0032201)3.74980941
18translational elongation (GO:0006414)3.67578834
19establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65931631
20DNA strand elongation (GO:0022616)3.62415485
21base-excision repair, AP site formation (GO:0006285)3.58684220
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.57888587
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.57023778
24protein targeting to mitochondrion (GO:0006626)3.54862467
25pyrimidine nucleoside salvage (GO:0043097)3.50694013
26pyrimidine-containing compound salvage (GO:0008655)3.50694013
27pyrimidine nucleotide catabolic process (GO:0006244)3.50198682
28peptidyl-arginine omega-N-methylation (GO:0035247)3.48957054
29antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.46254628
30GDP-mannose metabolic process (GO:0019673)3.43419256
312-deoxyribonucleotide metabolic process (GO:0009394)3.41628766
32formation of translation preinitiation complex (GO:0001731)3.38970389
33deoxyribose phosphate biosynthetic process (GO:0046385)3.38188061
342-deoxyribonucleotide biosynthetic process (GO:0009265)3.38188061
35folic acid metabolic process (GO:0046655)3.37414828
36oxidative phosphorylation (GO:0006119)3.36509347
37translational initiation (GO:0006413)3.33584187
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33016196
39negative regulation of ligase activity (GO:0051352)3.33016196
40nucleoside salvage (GO:0043174)3.31273663
41telomere maintenance via recombination (GO:0000722)3.29412349
42maturation of SSU-rRNA (GO:0030490)3.28302951
43negative regulation of B cell apoptotic process (GO:0002903)3.27705429
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27126939
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26840721
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25728894
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25598332
48establishment of protein localization to mitochondrion (GO:0072655)3.25560152
49DNA replication initiation (GO:0006270)3.23976533
50cellular protein complex disassembly (GO:0043624)3.21932384
51viral life cycle (GO:0019058)3.21128138
52translation (GO:0006412)3.20322071
53purine deoxyribonucleotide catabolic process (GO:0009155)3.19625093
54purine nucleotide salvage (GO:0032261)3.19144524
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19098795
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19098795
57nucleobase biosynthetic process (GO:0046112)3.18337769
58pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.17868542
59termination of RNA polymerase III transcription (GO:0006386)3.16858868
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.16858868
61deoxyribose phosphate metabolic process (GO:0019692)3.16666770
62rRNA modification (GO:0000154)3.15537874
63protein deneddylation (GO:0000338)3.15442554
64DNA unwinding involved in DNA replication (GO:0006268)3.15170532
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14435884
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14435884
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14435884
68pentose metabolic process (GO:0019321)3.13675933
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11759404
70regulation of cellular amino acid metabolic process (GO:0006521)3.10631505
71heme biosynthetic process (GO:0006783)3.10522539
72purine deoxyribonucleotide metabolic process (GO:0009151)3.09287827
73signal peptide processing (GO:0006465)3.08538129
74metallo-sulfur cluster assembly (GO:0031163)3.08131962
75iron-sulfur cluster assembly (GO:0016226)3.08131962
76pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.07200896
77pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.06358084
78DNA replication checkpoint (GO:0000076)3.04835842
79pseudouridine synthesis (GO:0001522)3.04695675
80mitochondrial respiratory chain complex assembly (GO:0033108)3.03931628
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02755000
82signal transduction involved in DNA damage checkpoint (GO:0072422)3.02755000
83mitochondrial fusion (GO:0008053)3.02552665
84ribonucleoprotein complex biogenesis (GO:0022613)3.00740465
85pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.00571105
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00418073
87protein maturation by protein folding (GO:0022417)2.99675467
88regulation of translational fidelity (GO:0006450)2.98838355
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98252983
90pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.96349184
91purine nucleobase biosynthetic process (GO:0009113)2.96235930
92deoxyribonucleotide biosynthetic process (GO:0009263)2.95687098
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.95457978
94protein localization to mitochondrion (GO:0070585)2.95365737
95purine-containing compound salvage (GO:0043101)2.95046449
96nucleobase-containing small molecule interconversion (GO:0015949)2.94543972
97tRNA modification (GO:0006400)2.94312330
98protein retention in ER lumen (GO:0006621)2.93486471
99deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.93350911
100peptidyl-histidine modification (GO:0018202)2.87804987
101ribosomal large subunit biogenesis (GO:0042273)2.87752783
102deoxyribonucleotide metabolic process (GO:0009262)2.87272694
103tRNA methylation (GO:0030488)2.87130460
104guanosine-containing compound biosynthetic process (GO:1901070)2.87125944
105pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.85621644
106base-excision repair (GO:0006284)2.85057452
107cullin deneddylation (GO:0010388)2.83481116
108UTP biosynthetic process (GO:0006228)2.83300842
109mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82929018
110mitotic nuclear envelope reassembly (GO:0007084)2.82290538
111nuclear envelope reassembly (GO:0031468)2.82290538
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.82008459
113NADH dehydrogenase complex assembly (GO:0010257)2.82008459
114mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82008459
115respiratory electron transport chain (GO:0022904)2.81956617
116neutrophil activation involved in immune response (GO:0002283)2.81836896
117ribosome biogenesis (GO:0042254)2.81695596
118purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.81673757
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81436942
120cellular component biogenesis (GO:0044085)2.81136651
121protein insertion into membrane (GO:0051205)2.80698032
122rRNA processing (GO:0006364)2.79465893
123mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79362886
124chaperone-mediated protein transport (GO:0072321)2.78627274
125deoxyribonucleotide catabolic process (GO:0009264)2.78387295
126response to interferon-beta (GO:0035456)2.78295311
127histone arginine methylation (GO:0034969)2.78279148
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.77990376
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77306170
130heme metabolic process (GO:0042168)2.77196702
131protein complex disassembly (GO:0043241)2.76885979
132positive regulation of ligase activity (GO:0051351)2.75225962
133peptidyl-arginine N-methylation (GO:0035246)2.74702873
134peptidyl-arginine methylation (GO:0018216)2.74702873
135antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.74534659
136transcription-coupled nucleotide-excision repair (GO:0006283)2.74428319
1377-methylguanosine mRNA capping (GO:0006370)2.73562630
138UV protection (GO:0009650)2.73211000
139electron transport chain (GO:0022900)2.72738043
140protein complex biogenesis (GO:0070271)2.71624172
141mitotic recombination (GO:0006312)2.71443395
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69681711
143nucleotide-excision repair, DNA gap filling (GO:0006297)2.69221648
144L-methionine salvage (GO:0071267)2.68596588
145L-methionine biosynthetic process (GO:0071265)2.68596588
146amino acid salvage (GO:0043102)2.68596588
147macromolecular complex disassembly (GO:0032984)2.67459247
1487-methylguanosine RNA capping (GO:0009452)2.64508336
149RNA capping (GO:0036260)2.64508336
150deoxyribose phosphate catabolic process (GO:0046386)2.64295425
151telomere maintenance via telomere lengthening (GO:0010833)2.64226735
152rRNA metabolic process (GO:0016072)2.63937594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.36613326
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96635472
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36895270
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.34467460
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32171638
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.31741439
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10483652
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.92855058
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.86924837
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74658503
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63734556
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61595055
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.50870685
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43655343
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.30468622
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.27828607
17* VDR_23849224_ChIP-Seq_CD4+_Human2.25338541
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24737694
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17706671
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.16999792
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10829203
22* XRN2_22483619_ChIP-Seq_HELA_Human2.09603492
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06328590
24* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03528282
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01919699
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00061120
27* GABP_19822575_ChIP-Seq_HepG2_Human1.99790021
28DCP1A_22483619_ChIP-Seq_HELA_Human1.99651069
29FOXP3_21729870_ChIP-Seq_TREG_Human1.96649031
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94582022
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94107996
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92730949
33LXR_22292898_ChIP-Seq_THP-1_Human1.89208787
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86778178
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85371577
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82449907
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.82297195
38* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81074887
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80222807
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.76413858
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.75091869
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.74160887
43* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73260679
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71482727
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.68111328
46P68_20966046_ChIP-Seq_HELA_Human1.67735069
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.67008846
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65446698
49VDR_21846776_ChIP-Seq_THP-1_Human1.63672383
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63463057
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60799854
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60617585
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56044532
54SPI1_23547873_ChIP-Seq_NB4_Human1.53788778
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51207285
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49802416
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.46993413
58TTF2_22483619_ChIP-Seq_HELA_Human1.46915090
59ZNF263_19887448_ChIP-Seq_K562_Human1.43703618
60MYC_22102868_ChIP-Seq_BL_Human1.43426142
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.42275935
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39240328
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38992507
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.38608966
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37901868
66RACK7_27058665_Chip-Seq_MCF-7_Human1.37672144
67* BCL6_27268052_Chip-Seq_Bcells_Human1.35913861
68CIITA_25753668_ChIP-Seq_RAJI_Human1.34714996
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34487592
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33869917
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32699369
72* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32517504
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32263431
74BCOR_27268052_Chip-Seq_Bcells_Human1.30847430
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30038161
76* FOXP1_21924763_ChIP-Seq_HESCs_Human1.28809878
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28073129
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28028158
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26682008
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25589879
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.24784178
82* NCOR1_26117541_ChIP-Seq_K562_Human1.23150482
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20956556
84ELK1_19687146_ChIP-ChIP_HELA_Human1.20346538
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20199621
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19407658
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19304230
88PHF8_20622854_ChIP-Seq_HELA_Human1.16380288
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16255176
90* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16018758
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14614989
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12418258
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12055241
94CTCF_21964334_Chip-Seq_Bcells_Human1.11704319
95E2F1_20622854_ChIP-Seq_HELA_Human1.10051040
96VDR_24763502_ChIP-Seq_THP-1_Human1.09510425
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08952050
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08903010
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08799015
100UTX_26944678_Chip-Seq_JUKART_Human1.08791295
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08595501
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08570508
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08168178
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.07622655
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07501540
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07338310
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07308706
108SCL_19346495_ChIP-Seq_HPC-7_Human1.06806636
109TFEB_21752829_ChIP-Seq_HELA_Human1.06589815
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06316164
111KDM5A_27292631_Chip-Seq_BREAST_Human1.06171211
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05847234
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.05606291
114SMC4_20622854_ChIP-Seq_HELA_Human1.04273412
115RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04070817
116* CTCF_26484167_Chip-Seq_Bcells_Mouse1.03617739
117* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02727730
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00452262
119* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99102388
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.98772279
121MAF_26560356_Chip-Seq_TH2_Human0.98517965
122NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98355927
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.97853553
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97251695
125FOXM1_23109430_ChIP-Seq_U2OS_Human0.96804323
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96459214
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95155951
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94755710
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94404885
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94386142
131MAF_26560356_Chip-Seq_TH1_Human0.94071242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.09244309
2MP0003693_abnormal_embryo_hatching3.07715178
3MP0002396_abnormal_hematopoietic_system2.79434871
4MP0000685_abnormal_immune_system2.67023107
5MP0003656_abnormal_erythrocyte_physiolo2.63636259
6MP0009785_altered_susceptibility_to2.47904488
7MP0005671_abnormal_response_to2.46324074
8MP0003186_abnormal_redox_activity2.42897382
9MP0003806_abnormal_nucleotide_metabolis2.39601084
10MP0009333_abnormal_splenocyte_physiolog2.36594555
11MP0004957_abnormal_blastocyst_morpholog2.29352859
12MP0010094_abnormal_chromosome_stability2.25892125
13MP0003763_abnormal_thymus_physiology2.25763142
14MP0002148_abnormal_hypersensitivity_rea2.19645343
15MP0008007_abnormal_cellular_replicative2.13550338
16MP0003436_decreased_susceptibility_to2.11668121
17MP0003077_abnormal_cell_cycle2.09830221
18MP0001545_abnormal_hematopoietic_system2.09199988
19MP0005397_hematopoietic_system_phenotyp2.09199988
20MP0006054_spinal_hemorrhage2.05110682
21MP0005025_abnormal_response_to1.99696596
22MP0005000_abnormal_immune_tolerance1.99360633
23MP0006036_abnormal_mitochondrial_physio1.97821908
24MP0005083_abnormal_biliary_tract1.97578989
25MP0009840_abnormal_foam_cell1.97338216
26MP0002398_abnormal_bone_marrow1.96043163
27MP0003724_increased_susceptibility_to1.95413494
28MP0008058_abnormal_DNA_repair1.93695749
29MP0002249_abnormal_larynx_morphology1.89464281
30MP0002420_abnormal_adaptive_immunity1.88070361
31MP0001819_abnormal_immune_cell1.86224734
32MP0002452_abnormal_antigen_presenting1.84293882
33MP0001661_extended_life_span1.84267755
34MP0003111_abnormal_nucleus_morphology1.82607805
35MP0002723_abnormal_immune_serum1.82574355
36MP0001800_abnormal_humoral_immune1.81228036
37MP0005464_abnormal_platelet_physiology1.80764132
38MP0002419_abnormal_innate_immunity1.78271944
39MP0000689_abnormal_spleen_morphology1.74660326
40MP0000490_abnormal_crypts_of1.70569310
41MP0009278_abnormal_bone_marrow1.70110363
42MP0000716_abnormal_immune_system1.69411895
43MP0000681_abnormal_thyroid_gland1.68841960
44MP0002132_abnormal_respiratory_system1.67203092
45MP0002429_abnormal_blood_cell1.67183914
46MP0002722_abnormal_immune_system1.65575655
47MP0004233_abnormal_muscle_weight1.65430347
48MP0004808_abnormal_hematopoietic_stem1.64286372
49MP0005410_abnormal_fertilization1.62251025
50MP0005451_abnormal_body_composition1.61915468
51MP0009379_abnormal_foot_pigmentation1.60686336
52MP0000465_gastrointestinal_hemorrhage1.60396552
53MP0001853_heart_inflammation1.59617247
54MP0001764_abnormal_homeostasis1.56512020
55MP0004147_increased_porphyrin_level1.54728316
56MP0005058_abnormal_lysosome_morphology1.44184818
57MP0005075_abnormal_melanosome_morpholog1.42570729
58MP0002405_respiratory_system_inflammati1.42537179
59MP0005387_immune_system_phenotype1.41318521
60MP0001790_abnormal_immune_system1.41318521
61MP0006082_CNS_inflammation1.38322045
62MP0002877_abnormal_melanocyte_morpholog1.36602990
63MP0001348_abnormal_lacrimal_gland1.36475886
64MP0000750_abnormal_muscle_regeneration1.33637216
65MP0001845_abnormal_inflammatory_respons1.32888195
66MP0008469_abnormal_protein_level1.32723474
67MP0008995_early_reproductive_senescence1.31305504
68MP0008932_abnormal_embryonic_tissue1.29895417
69MP0005330_cardiomyopathy1.28988831
70MP0001986_abnormal_taste_sensitivity1.26591664
71MP0000703_abnormal_thymus_morphology1.26463872
72MP0005171_absent_coat_pigmentation1.26015309
73MP0005501_abnormal_skin_physiology1.23617324
74MP0004185_abnormal_adipocyte_glucose1.22756941
75MP0000858_altered_metastatic_potential1.22713092
76MP0002019_abnormal_tumor_incidence1.22382297
77MP0000343_altered_response_to1.21065679
78MP0000358_abnormal_cell_content/1.20685267
79MP0005310_abnormal_salivary_gland1.19336121
80MP0003786_premature_aging1.18328513
81MP0000003_abnormal_adipose_tissue1.17323295
82MP0000015_abnormal_ear_pigmentation1.16593386
83MP0001730_embryonic_growth_arrest1.14926800
84MP0004858_abnormal_nervous_system1.14790099
85MP0010030_abnormal_orbit_morphology1.14481720
86MP0000313_abnormal_cell_death1.13072831
87MP0002234_abnormal_pharynx_morphology1.11502761
88MP0008877_abnormal_DNA_methylation1.10573376
89MP0003191_abnormal_cellular_cholesterol1.10089592
90MP0001533_abnormal_skeleton_physiology1.09829617
91MP0000747_muscle_weakness1.05648093
92MP0003866_abnormal_defecation1.01567731
93MP0008057_abnormal_DNA_replication1.01376861
94MP0009697_abnormal_copulation1.00061155
95MP0010155_abnormal_intestine_physiology0.99597004
96MP0006035_abnormal_mitochondrial_morpho0.99272734
97MP0005636_abnormal_mineral_homeostasis0.97825157
98MP0002080_prenatal_lethality0.97674879
99MP0001346_abnormal_lacrimal_gland0.97119078
100MP0001929_abnormal_gametogenesis0.96408746
101MP0002160_abnormal_reproductive_system0.96365758
102MP0002210_abnormal_sex_determination0.96001254
103MP0005174_abnormal_tail_pigmentation0.95656699
104MP0002163_abnormal_gland_morphology0.94093938
105MP0004510_myositis0.91855486
106MP0001188_hyperpigmentation0.87537510
107MP0010307_abnormal_tumor_latency0.85349658
108MP0001529_abnormal_vocalization0.84628977
109MP0000759_abnormal_skeletal_muscle0.84389039
110MP0005645_abnormal_hypothalamus_physiol0.83546870
111MP0000751_myopathy0.82975155
112MP0009643_abnormal_urine_homeostasis0.81670864
113MP0008260_abnormal_autophagy0.81516948
114MP0001697_abnormal_embryo_size0.79941568
115MP0008875_abnormal_xenobiotic_pharmacok0.78055852
116MP0005319_abnormal_enzyme/_coenzyme0.77788578
117MP0003172_abnormal_lysosome_physiology0.77507697
118MP0003718_maternal_effect0.77381754
119MP0005332_abnormal_amino_acid0.76827140
120MP0000678_abnormal_parathyroid_gland0.75265434
121MP0002933_joint_inflammation0.74261668
122MP0000350_abnormal_cell_proliferation0.74216774
123MP0001542_abnormal_bone_strength0.72938771
124MP0001145_abnormal_male_reproductive0.72892084
125MP0005423_abnormal_somatic_nervous0.72711324
126MP0000598_abnormal_liver_morphology0.72681215
127MP0001727_abnormal_embryo_implantation0.71912912
128MP0000372_irregular_coat_pigmentation0.71688302
129MP0009763_increased_sensitivity_to0.71643254
130MP0005584_abnormal_enzyme/coenzyme_acti0.71634579
131MP0005384_cellular_phenotype0.69875808
132MP0001873_stomach_inflammation0.69403383
133MP0004947_skin_inflammation0.69252805
134MP0002822_catalepsy0.68711989
135MP0005375_adipose_tissue_phenotype0.68708385
136MP0001905_abnormal_dopamine_level0.67511349
137MP0002970_abnormal_white_adipose0.66913734
138MP0001881_abnormal_mammary_gland0.66241561
139MP0004381_abnormal_hair_follicle0.66147542
140MP0009931_abnormal_skin_appearance0.65682483
141MP0002269_muscular_atrophy0.64552489
142MP0005623_abnormal_meninges_morphology0.64435266
143MP0003453_abnormal_keratinocyte_physiol0.63839752

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.26577657
2Thrombocytosis (HP:0001894)4.20506225
3Abnormality of cells of the erythroid lineage (HP:0012130)4.14074009
4Truncus arteriosus (HP:0001660)4.13746365
5Hyperthyroidism (HP:0000836)3.99504626
6Ragged-red muscle fibers (HP:0003200)3.91003837
7Microvesicular hepatic steatosis (HP:0001414)3.81885738
8Hypertensive crisis (HP:0100735)3.68251495
9Aplastic anemia (HP:0001915)3.67429988
10Testicular atrophy (HP:0000029)3.66864359
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.61005984
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.61005984
13Elevated erythrocyte sedimentation rate (HP:0003565)3.57200571
14Hepatocellular necrosis (HP:0001404)3.55438875
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.51506386
16Progressive muscle weakness (HP:0003323)3.45527833
17Petechiae (HP:0000967)3.40644731
18Hepatic necrosis (HP:0002605)3.33185312
19Microretrognathia (HP:0000308)3.21685363
20Type I transferrin isoform profile (HP:0003642)3.20492212
21Mitochondrial inheritance (HP:0001427)3.11837099
22Reduced antithrombin III activity (HP:0001976)3.11183732
23Abnormal gallbladder physiology (HP:0012438)3.07173611
24Cholecystitis (HP:0001082)3.07173611
25Exertional dyspnea (HP:0002875)3.06755327
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03997179
273-Methylglutaconic aciduria (HP:0003535)3.01339400
28Seborrheic dermatitis (HP:0001051)2.98450711
29Increased hepatocellular lipid droplets (HP:0006565)2.97936057
30Poor head control (HP:0002421)2.94932486
31Lipid accumulation in hepatocytes (HP:0006561)2.94413066
32Myopathic facies (HP:0002058)2.91609934
33Acute necrotizing encephalopathy (HP:0006965)2.89207537
34Increased CSF lactate (HP:0002490)2.87388760
35Birth length less than 3rd percentile (HP:0003561)2.86200634
36Abnormal protein glycosylation (HP:0012346)2.86185374
37Abnormal glycosylation (HP:0012345)2.86185374
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.86185374
39Abnormal protein N-linked glycosylation (HP:0012347)2.86185374
40Myositis (HP:0100614)2.81072821
41Reticulocytopenia (HP:0001896)2.79244250
42Abnormal mitochondria in muscle tissue (HP:0008316)2.77730288
43Cerebral hypomyelination (HP:0006808)2.74384831
44Vertebral compression fractures (HP:0002953)2.73074842
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72889343
46Increased serum lactate (HP:0002151)2.71729690
47Macrocytic anemia (HP:0001972)2.70084752
48Recurrent abscess formation (HP:0002722)2.67760678
49Recurrent bacterial skin infections (HP:0005406)2.64506511
50IgM deficiency (HP:0002850)2.62807299
51Abnormality of alanine metabolism (HP:0010916)2.62426197
52Hyperalaninemia (HP:0003348)2.62426197
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62426197
54Generalized aminoaciduria (HP:0002909)2.61121473
55Recurrent bronchitis (HP:0002837)2.56950316
56Renal Fanconi syndrome (HP:0001994)2.53275576
57Degeneration of anterior horn cells (HP:0002398)2.50688950
58Abnormality of the anterior horn cell (HP:0006802)2.50688950
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50666511
60Dicarboxylic aciduria (HP:0003215)2.50666511
61Acute encephalopathy (HP:0006846)2.49728778
62Increased intramyocellular lipid droplets (HP:0012240)2.47110228
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45075500
64Squamous cell carcinoma (HP:0002860)2.44533154
65Abnormality of T cell physiology (HP:0011840)2.42361344
66Atelectasis (HP:0100750)2.41901247
67Lactic acidosis (HP:0003128)2.40714737
68Cholelithiasis (HP:0001081)2.40141212
69Hypokinesia (HP:0002375)2.36275123
70Increased muscle lipid content (HP:0009058)2.35319420
71Esophageal neoplasm (HP:0100751)2.32172641
72Neoplasm of head and neck (HP:0012288)2.32172641
73Pancytopenia (HP:0001876)2.30956001
74Pallor (HP:0000980)2.30484584
75Broad distal phalanx of finger (HP:0009836)2.28184251
76Abnormality of macrophages (HP:0004311)2.27447007
77Stridor (HP:0010307)2.26199673
78Neutropenia (HP:0001875)2.25800979
79Chronic otitis media (HP:0000389)2.25479156
80Poikiloderma (HP:0001029)2.25206825
81Abnormality of reticulocytes (HP:0004312)2.21032702
82Abnormality of the tricuspid valve (HP:0001702)2.20710687
83Purpura (HP:0000979)2.17413383
84Opisthotonus (HP:0002179)2.17242676
85Abnormal large intestine physiology (HP:0012700)2.16816065
86Exercise intolerance (HP:0003546)2.15934941
87Breast hypoplasia (HP:0003187)2.15829557
88Hypoparathyroidism (HP:0000829)2.15372317
89Reticulocytosis (HP:0001923)2.14488988
90Cerebral edema (HP:0002181)2.14130382
91Chronic obstructive pulmonary disease (HP:0006510)2.13490944
92Obstructive lung disease (HP:0006536)2.13490944
93Vacuolated lymphocytes (HP:0001922)2.12428131
94Type 2 muscle fiber atrophy (HP:0003554)2.09428024
95Nasal polyposis (HP:0100582)2.08663375
96Abnormality of T cells (HP:0002843)2.07960190
97Muscle fiber atrophy (HP:0100295)2.07345008
98Abnormality of glycolipid metabolism (HP:0010969)2.06908336
99Abnormality of liposaccharide metabolism (HP:0010968)2.06908336
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.06908336
101Bowel incontinence (HP:0002607)2.04256467
102Abnormality of glycolysis (HP:0004366)2.03733272
103Increased serum pyruvate (HP:0003542)2.03733272
104Self-mutilation (HP:0000742)2.01499475
105Increased serum ferritin (HP:0003281)2.00996181
106Abnormal gallbladder morphology (HP:0012437)1.99980573
107Vaginal fistula (HP:0004320)1.99870159
108Selective tooth agenesis (HP:0001592)1.98605226
109Severe visual impairment (HP:0001141)1.97284052
110Progressive macrocephaly (HP:0004481)1.96941642
111Respiratory failure (HP:0002878)1.96870273
112Respiratory difficulties (HP:0002880)1.95459923
113Abnormality of the gallbladder (HP:0005264)1.95031727
114Oral leukoplakia (HP:0002745)1.93237435
115Beaking of vertebral bodies (HP:0004568)1.92487295
116Premature ovarian failure (HP:0008209)1.90526161
117Rough bone trabeculation (HP:0100670)1.90430532
118Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89552570
119Centrally nucleated skeletal muscle fibers (HP:0003687)1.88052047
120Methylmalonic aciduria (HP:0012120)1.86943081
121Eczematoid dermatitis (HP:0000976)1.86067054
122Hypergonadotropic hypogonadism (HP:0000815)1.85911893
123Pulmonary fibrosis (HP:0002206)1.85910278
124Septate vagina (HP:0001153)1.85557652
125Delusions (HP:0000746)1.84328848
126Rhabdomyolysis (HP:0003201)1.83744231
127Abnormality of B cell number (HP:0010975)1.83736912
128B lymphocytopenia (HP:0010976)1.83736912
129Epistaxis (HP:0000421)1.82715773
130Spastic paraparesis (HP:0002313)1.80749345
131Congenital malformation of the right heart (HP:0011723)1.79999211
132Double outlet right ventricle (HP:0001719)1.79999211
133Recurrent skin infections (HP:0001581)1.79715029
134Entropion (HP:0000621)1.79462115
135Abnormality of the nasal mucosa (HP:0000433)1.79177667
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77959973
137Rectovaginal fistula (HP:0000143)1.77955931
138Rectal fistula (HP:0100590)1.77955931
139Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77604639
140Aplasia/Hypoplasia of the thymus (HP:0010515)1.77362820
141Agnosia (HP:0010524)1.77132074
142Orchitis (HP:0100796)1.77027700
143Prolonged neonatal jaundice (HP:0006579)1.76963425
144Premature graying of hair (HP:0002216)1.76377895
145Cutaneous melanoma (HP:0012056)1.76351790
146IgG deficiency (HP:0004315)1.75168456
147Nonimmune hydrops fetalis (HP:0001790)1.75011813
148Emotional lability (HP:0000712)1.74040210
149Abnormal spermatogenesis (HP:0008669)1.73636454
150Megaloblastic anemia (HP:0001889)1.73571662
151Meningitis (HP:0001287)1.72440743
152Progressive microcephaly (HP:0000253)1.72355574
153Lymphoma (HP:0002665)1.71811463
154Recurrent gram-negative bacterial infections (HP:0005420)1.71510254
155Agammaglobulinemia (HP:0004432)1.71336852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM24.39148181
2NME24.34190436
3ARAF3.42484293
4STK163.38051802
5EIF2AK12.91754882
6BUB12.69598620
7SMG12.53794406
8VRK22.47417517
9TESK22.46549979
10BRAF2.40949427
11MAP4K12.39149926
12TESK12.13487238
13WEE12.00088874
14EIF2AK31.91086002
15BCKDK1.89393292
16TLK11.77236671
17ERN11.68498652
18PIK3CG1.68195786
19FLT31.67971324
20KIT1.65481154
21IRAK41.65448902
22TBK11.51214172
23ACVR1B1.50791568
24VRK11.46903697
25CCNB11.42414250
26MAPK111.42337938
27PDK21.40709263
28CDK191.39731446
29KDR1.39716866
30ZAP701.33281873
31BTK1.28793725
32PIM11.25846721
33BLK1.23391676
34ICK1.20520907
35ZAK1.20000607
36PBK1.18332544
37NME11.15261433
38DYRK31.14528126
39CDK81.14257077
40TAOK21.13725436
41ILK1.12555903
42RAF11.09587592
43MAP3K111.07930036
44JAK31.07614488
45IKBKB1.06799825
46PRPF4B1.04508173
47CLK11.03792917
48ABL21.02776914
49TYK21.02584121
50IRAK21.01689166
51CDC71.00757541
52SCYL21.00619256
53CSF1R0.98263007
54SYK0.98098676
55CHEK20.97842947
56RPS6KA40.96293206
57TXK0.95712428
58PLK40.93796652
59PRKD30.93346467
60IKBKE0.91345251
61IRAK30.90715291
62BRSK20.90558922
63NEK20.89044434
64LRRK20.88178230
65MAP3K140.83716091
66TSSK60.83657207
67SRPK10.83121677
68MAPKAPK30.82556285
69TEC0.80324420
70PAK10.80167070
71TRIB30.78920435
72MAPK120.77274040
73NEK90.77040559
74SIK10.76376340
75PLK10.75756172
76MAP3K30.74886181
77CDK120.73112250
78MAP3K10.72110751
79TTK0.71412398
80CDK70.71358365
81PASK0.70923058
82AURKA0.70597797
83LIMK10.69876491
84NEK10.67025397
85CHEK10.66206494
86KSR20.65939056
87DAPK30.65430961
88GRK60.62459971
89PAK40.62247634
90CSNK1G30.60510999
91TAOK10.60341960
92STK100.59401656
93MOS0.58238171
94TAOK30.57180931
95AKT20.56446671
96RPS6KA50.55750732
97AURKB0.55121559
98ATR0.55036896
99SIK20.54754387
100MAP3K80.54578622
101MAP3K100.54055933
102LYN0.53497935
103MAP2K30.52325603
104PDPK10.52045225
105RPS6KA60.50571806
106EEF2K0.50227434
107MAPKAPK50.49762973
108STK40.49577253
109PRKD20.48982010
110MUSK0.48624336
111CAMK2G0.47991327
112LCK0.47575817
113BRSK10.47319724
114CSNK2A10.46624692
115CDK40.45992637
116MAPK150.44756032
117CDK11A0.43462524
118MAPKAPK20.43084276
119DAPK10.42448433
120CDK20.41682888
121MATK0.41662051
122TGFBR10.41020896
123BMX0.40812768
124CSNK2A20.39550637
125ADRBK20.39416478
126CDK90.39299829
127RPS6KB20.39130187
128MTOR0.39073274
129BMPR20.38989063
130CDK140.38040328
131RIPK40.37891487
132RPS6KC10.37407677
133RPS6KL10.37407677
134STK240.37266283
135SIK30.37187735
136PRKCD0.37103848
137MAP2K20.37011563
138PRKCI0.36947667

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.16500951
2DNA replication_Homo sapiens_hsa030304.04828350
3Proteasome_Homo sapiens_hsa030504.03329291
4RNA polymerase_Homo sapiens_hsa030203.21030433
5Mismatch repair_Homo sapiens_hsa034302.84371094
6Protein export_Homo sapiens_hsa030602.72400631
7Pyrimidine metabolism_Homo sapiens_hsa002402.64186854
8Base excision repair_Homo sapiens_hsa034102.62345895
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31601491
10Homologous recombination_Homo sapiens_hsa034402.27758743
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16508077
12Folate biosynthesis_Homo sapiens_hsa007902.11315698
13Nucleotide excision repair_Homo sapiens_hsa034202.04448992
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96577822
15Sulfur relay system_Homo sapiens_hsa041221.96163032
16Pentose phosphate pathway_Homo sapiens_hsa000301.94364847
17Spliceosome_Homo sapiens_hsa030401.86039884
18Oxidative phosphorylation_Homo sapiens_hsa001901.74945849
19Parkinsons disease_Homo sapiens_hsa050121.71705204
20Basal transcription factors_Homo sapiens_hsa030221.66960661
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63678129
22One carbon pool by folate_Homo sapiens_hsa006701.53207731
23RNA transport_Homo sapiens_hsa030131.44710620
24Cell cycle_Homo sapiens_hsa041101.44430395
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42412446
26Purine metabolism_Homo sapiens_hsa002301.40861208
27Huntingtons disease_Homo sapiens_hsa050161.39178501
28Non-homologous end-joining_Homo sapiens_hsa034501.18762073
29Primary immunodeficiency_Homo sapiens_hsa053401.17579758
30Fatty acid elongation_Homo sapiens_hsa000621.16926617
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12011739
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09943983
33Antigen processing and presentation_Homo sapiens_hsa046121.09417800
34RNA degradation_Homo sapiens_hsa030181.09336399
35p53 signaling pathway_Homo sapiens_hsa041151.05790770
36Legionellosis_Homo sapiens_hsa051341.04109281
37Vitamin B6 metabolism_Homo sapiens_hsa007501.00605674
38Other glycan degradation_Homo sapiens_hsa005110.99160463
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98921014
40Epstein-Barr virus infection_Homo sapiens_hsa051690.98474512
41Alzheimers disease_Homo sapiens_hsa050100.98069792
42Glutathione metabolism_Homo sapiens_hsa004800.96762065
43Herpes simplex infection_Homo sapiens_hsa051680.96548327
44Selenocompound metabolism_Homo sapiens_hsa004500.95862171
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.93854366
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91422607
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.90017086
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.87949420
49Allograft rejection_Homo sapiens_hsa053300.87316607
50Biosynthesis of amino acids_Homo sapiens_hsa012300.85280009
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85186484
52Leishmaniasis_Homo sapiens_hsa051400.82414900
53Measles_Homo sapiens_hsa051620.81919323
54Fanconi anemia pathway_Homo sapiens_hsa034600.81684794
55Regulation of autophagy_Homo sapiens_hsa041400.80613520
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78746141
57N-Glycan biosynthesis_Homo sapiens_hsa005100.78377053
58Shigellosis_Homo sapiens_hsa051310.77839040
59Fructose and mannose metabolism_Homo sapiens_hsa000510.75956380
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75604630
61Pyruvate metabolism_Homo sapiens_hsa006200.75529388
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74620811
63Bladder cancer_Homo sapiens_hsa052190.73816448
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71749865
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71188815
66Galactose metabolism_Homo sapiens_hsa000520.69363982
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66351216
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65134424
69Phenylalanine metabolism_Homo sapiens_hsa003600.64571952
70Carbon metabolism_Homo sapiens_hsa012000.62462887
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60994242
72Apoptosis_Homo sapiens_hsa042100.60054374
73Systemic lupus erythematosus_Homo sapiens_hsa053220.59481594
74Metabolic pathways_Homo sapiens_hsa011000.59187432
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58791169
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.57903593
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56267469
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.54282768
79Asthma_Homo sapiens_hsa053100.52432978
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52386905
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51184303
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49062406
83Malaria_Homo sapiens_hsa051440.48936106
84Lysosome_Homo sapiens_hsa041420.48711634
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47068457
86Pertussis_Homo sapiens_hsa051330.46422364
87Sulfur metabolism_Homo sapiens_hsa009200.45567016
88Viral carcinogenesis_Homo sapiens_hsa052030.45505093
89Tyrosine metabolism_Homo sapiens_hsa003500.45295486
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44794507
91mRNA surveillance pathway_Homo sapiens_hsa030150.44787170
92Alcoholism_Homo sapiens_hsa050340.43339669
93Hematopoietic cell lineage_Homo sapiens_hsa046400.43282123
94Peroxisome_Homo sapiens_hsa041460.43229924
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42231545
96Hepatitis B_Homo sapiens_hsa051610.41873609
97Influenza A_Homo sapiens_hsa051640.41858012
98Arginine and proline metabolism_Homo sapiens_hsa003300.41431956
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.40956133
100Non-small cell lung cancer_Homo sapiens_hsa052230.40866604
101HTLV-I infection_Homo sapiens_hsa051660.40400602
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40371249
103Phagosome_Homo sapiens_hsa041450.39846954
104Autoimmune thyroid disease_Homo sapiens_hsa053200.39595039
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39408085
106Arachidonic acid metabolism_Homo sapiens_hsa005900.39112670
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38585519
108Tuberculosis_Homo sapiens_hsa051520.38265356
109Thyroid cancer_Homo sapiens_hsa052160.37939183
110Acute myeloid leukemia_Homo sapiens_hsa052210.36842979
111B cell receptor signaling pathway_Homo sapiens_hsa046620.35495831
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35253781
113Collecting duct acid secretion_Homo sapiens_hsa049660.35031615
114Cardiac muscle contraction_Homo sapiens_hsa042600.34993450
115Vibrio cholerae infection_Homo sapiens_hsa051100.34127032
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33967531
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33462635
118Salmonella infection_Homo sapiens_hsa051320.30993253
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27676326
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27135707
121Chronic myeloid leukemia_Homo sapiens_hsa052200.26594861
122Synaptic vesicle cycle_Homo sapiens_hsa047210.26355310
123Fatty acid metabolism_Homo sapiens_hsa012120.25980327
124Pancreatic cancer_Homo sapiens_hsa052120.23485092
125Sphingolipid metabolism_Homo sapiens_hsa006000.23345901
126mTOR signaling pathway_Homo sapiens_hsa041500.19311062
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.18613459

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