THAP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.50507238
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.24125856
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.04461916
4neutrophil activation involved in immune response (GO:0002283)4.76404361
5establishment of mitochondrion localization (GO:0051654)4.74826516
6positive regulation of mitochondrial fission (GO:0090141)4.61237050
7superoxide anion generation (GO:0042554)4.58084557
8regulation of activation of Janus kinase activity (GO:0010533)4.50654866
9base-excision repair, AP site formation (GO:0006285)4.46513465
10negative regulation of mast cell activation (GO:0033004)4.41966826
11pyrimidine nucleotide catabolic process (GO:0006244)4.22712191
12cellular response to exogenous dsRNA (GO:0071360)4.17574195
13nucleobase catabolic process (GO:0046113)4.05732768
14metallo-sulfur cluster assembly (GO:0031163)4.04013875
15iron-sulfur cluster assembly (GO:0016226)4.04013875
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.96265757
17mitochondrion transport along microtubule (GO:0047497)3.96265757
18positive regulation of cellular amide metabolic process (GO:0034250)3.92247384
19neutrophil activation (GO:0042119)3.91906628
20response to peptidoglycan (GO:0032494)3.91571959
21negative regulation of viral genome replication (GO:0045071)3.87994203
22regulation of RIG-I signaling pathway (GO:0039535)3.85103314
23hydrogen peroxide biosynthetic process (GO:0050665)3.84760336
24dendritic cell chemotaxis (GO:0002407)3.78077694
25protein insertion into membrane (GO:0051205)3.77762146
26granulocyte activation (GO:0036230)3.76660274
27protein complex biogenesis (GO:0070271)3.76486170
28reactive oxygen species biosynthetic process (GO:1903409)3.63967225
29detection of molecule of bacterial origin (GO:0032490)3.61409282
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61164755
31chaperone-mediated protein transport (GO:0072321)3.58418584
32production of molecular mediator involved in inflammatory response (GO:0002532)3.56771676
33daunorubicin metabolic process (GO:0044597)3.56705194
34polyketide metabolic process (GO:0030638)3.56705194
35doxorubicin metabolic process (GO:0044598)3.56705194
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.56467999
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.56467999
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.52241389
39NADH dehydrogenase complex assembly (GO:0010257)3.52241389
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52241389
41cellular response to interferon-beta (GO:0035458)3.51040360
42positive regulation by symbiont of host defense response (GO:0052509)3.50561851
43modulation by symbiont of host defense response (GO:0052031)3.50561851
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50561851
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50561851
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.50561851
47modulation by symbiont of host immune response (GO:0052553)3.50561851
48eosinophil chemotaxis (GO:0048245)3.49551859
49defense response to protozoan (GO:0042832)3.48171180
50glyoxylate metabolic process (GO:0046487)3.44933338
51regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.44177740
52arginine catabolic process (GO:0006527)3.38982972
53cellular response to type I interferon (GO:0071357)3.38333380
54type I interferon signaling pathway (GO:0060337)3.38333380
55mitochondrial respiratory chain complex assembly (GO:0033108)3.37264875
56protein polyglutamylation (GO:0018095)3.36603717
57dendritic cell migration (GO:0036336)3.36399926
58respiratory burst (GO:0045730)3.34557179
59deoxyribonucleotide catabolic process (GO:0009264)3.34118114
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31039030
61response to type I interferon (GO:0034340)3.29889247
62piRNA metabolic process (GO:0034587)3.28618305
63viral protein processing (GO:0019082)3.28352948
64regulation of mast cell activation (GO:0033003)3.26566830
65positive regulation of interferon-alpha production (GO:0032727)3.23805121
66nonmotile primary cilium assembly (GO:0035058)3.22491171
67myeloid dendritic cell activation (GO:0001773)3.20883407
68cellular response to zinc ion (GO:0071294)3.20067200
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19706055
70ubiquinone biosynthetic process (GO:0006744)3.18642237
71natural killer cell activation involved in immune response (GO:0002323)3.17295916
72regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.17286492
73deoxyribose phosphate catabolic process (GO:0046386)3.14539642
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.14400507
75ubiquinone metabolic process (GO:0006743)3.13645056
76positive regulation of type 2 immune response (GO:0002830)3.11735121
77pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.10959981
78positive regulation of mast cell activation involved in immune response (GO:0033008)3.10627882
79positive regulation of mast cell degranulation (GO:0043306)3.10627882
80T-helper 1 type immune response (GO:0042088)3.09983564
81ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.09592443
82interferon-gamma production (GO:0032609)3.08715091
83ncRNA 3-end processing (GO:0043628)3.07552766
84intraciliary transport (GO:0042073)3.06670091
85positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.06496064
86mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.06306105
87positive regulation of interleukin-12 production (GO:0032735)3.04185229
88regulation of mast cell degranulation (GO:0043304)3.03977945
89mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02214553
90eosinophil migration (GO:0072677)3.01739015
91immunoglobulin mediated immune response (GO:0016064)3.00626633
92ribosomal small subunit assembly (GO:0000028)2.99998224
93regulation of interferon-alpha production (GO:0032647)2.99742039
94behavioral response to nicotine (GO:0035095)2.98339500
95regulation of meiosis I (GO:0060631)2.97533784
96response to protozoan (GO:0001562)2.97444004
97gamma-aminobutyric acid transport (GO:0015812)2.96157333
98chaperone-mediated protein complex assembly (GO:0051131)2.94427537
99regulation of mitochondrial translation (GO:0070129)2.94095134
100positive regulation of interleukin-17 production (GO:0032740)2.94073508
101negative regulation of telomere maintenance (GO:0032205)2.94009526
102response to interferon-beta (GO:0035456)2.92297077
103anterograde synaptic vesicle transport (GO:0048490)2.91938365
104response to misfolded protein (GO:0051788)2.91349616
105aldehyde catabolic process (GO:0046185)2.91048202
106regulation of mast cell activation involved in immune response (GO:0033006)2.90281460
107positive regulation of antigen processing and presentation (GO:0002579)2.88893769
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88751036
109positive regulation of natural killer cell differentiation (GO:0032825)2.85078462
110arginine metabolic process (GO:0006525)2.84436882
111positive regulation of monocyte chemotaxis (GO:0090026)2.83982438
112male meiosis I (GO:0007141)2.83671118
113myeloid dendritic cell differentiation (GO:0043011)2.83101588
114positive regulation of lymphocyte migration (GO:2000403)2.80687263
115energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80459897
116ATP synthesis coupled proton transport (GO:0015986)2.80459897
117detection of other organism (GO:0098543)2.79983201
118water-soluble vitamin biosynthetic process (GO:0042364)2.79681669
119monocyte chemotaxis (GO:0002548)2.78416200
120regulation of mitochondrial fission (GO:0090140)2.77905516
121regulation of lymphocyte chemotaxis (GO:1901623)2.77297323
122positive regulation of mast cell activation (GO:0033005)2.76488178
123positive regulation of defense response to virus by host (GO:0002230)2.75734501
124detection of external biotic stimulus (GO:0098581)2.74787600
125poly(A)+ mRNA export from nucleus (GO:0016973)2.74624668
126response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.73389258
127response to host immune response (GO:0052572)2.73389258
128intracellular protein transmembrane import (GO:0044743)2.73363291
129cell proliferation in forebrain (GO:0021846)2.73294957
130superoxide metabolic process (GO:0006801)2.73180177
131natural killer cell mediated cytotoxicity (GO:0042267)2.72177122
132natural killer cell mediated immunity (GO:0002228)2.72177122
133positive regulation of T cell migration (GO:2000406)2.72073869
134positive regulation of interleukin-1 beta secretion (GO:0050718)2.71160825
135mast cell activation (GO:0045576)2.70223955
136termination of RNA polymerase III transcription (GO:0006386)2.69209283
137transcription elongation from RNA polymerase III promoter (GO:0006385)2.69209283
138positive regulation of male gonad development (GO:2000020)2.69137507
139response to muramyl dipeptide (GO:0032495)2.68932198
140myeloid cell activation involved in immune response (GO:0002275)2.68602318
141spinal cord development (GO:0021510)2.68083553
142L-serine metabolic process (GO:0006563)2.68058444
143mannosylation (GO:0097502)2.67644189
144protein neddylation (GO:0045116)2.67355421
145negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.66599067
146protein maturation by protein folding (GO:0022417)2.66559048
147regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.65915462
148leukocyte aggregation (GO:0070486)2.65412885
149positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.65303046
150establishment of protein localization to mitochondrion (GO:0072655)2.64688353
151myeloid leukocyte activation (GO:0002274)2.63735182
152cullin deneddylation (GO:0010388)2.63679790
153mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63290840
154regulation of synapse structural plasticity (GO:0051823)2.62531395
155interferon-gamma-mediated signaling pathway (GO:0060333)2.62449712
156T cell migration (GO:0072678)2.62281174
157regulation of male gonad development (GO:2000018)2.62172300
158protein deneddylation (GO:0000338)2.61745197
159regulation of T cell chemotaxis (GO:0010819)2.60778370
160positive regulation of T cell chemotaxis (GO:0010820)2.60778370
161regulation of interleukin-17 production (GO:0032660)2.60264046
162positive regulation of interleukin-10 production (GO:0032733)2.59684289
163inner mitochondrial membrane organization (GO:0007007)2.58491203
164positive regulation of cAMP-mediated signaling (GO:0043950)2.57472034
165regulation of interleukin-12 biosynthetic process (GO:0045075)2.57346249
166negative regulation of meiosis (GO:0045835)2.57195709
167microtubule severing (GO:0051013)2.56093864
168negative regulation of interleukin-17 production (GO:0032700)2.55810299
169seminiferous tubule development (GO:0072520)2.55271667
170I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.54982726
171anterograde axon cargo transport (GO:0008089)2.54588157
172negative regulation of growth of symbiont in host (GO:0044130)2.54347044
173negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.54347044
174modulation of growth of symbiont involved in interaction with host (GO:0044144)2.54347044
175regulation of growth of symbiont in host (GO:0044126)2.54347044
176leukocyte degranulation (GO:0043299)2.53131081
177regulation of cilium movement (GO:0003352)2.52846166
178energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.51366060
179ATP hydrolysis coupled proton transport (GO:0015991)2.51366060
180negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50643851
181middle ear morphogenesis (GO:0042474)2.50532973
182head development (GO:0060322)2.50227416
183cholesterol biosynthetic process (GO:0006695)2.49846278
184mesenchymal cell differentiation involved in kidney development (GO:0072161)2.49536396
185mesenchymal cell differentiation involved in renal system development (GO:2001012)2.49536396
186UV protection (GO:0009650)2.49522342
187protein localization to mitochondrion (GO:0070585)2.48745219
188positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.48419051
1892-deoxyribonucleotide metabolic process (GO:0009394)2.47332122
190brain morphogenesis (GO:0048854)2.46003152
191regulation of microtubule-based movement (GO:0060632)2.45790566
192sulfur amino acid catabolic process (GO:0000098)2.45083581
193sterol biosynthetic process (GO:0016126)2.44197209
194erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.43504757
195L-phenylalanine catabolic process (GO:0006559)2.43504757
196negative regulation of DNA-templated transcription, elongation (GO:0032785)2.43139136
197positive regulation of TOR signaling (GO:0032008)2.42297952
198regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.42247721
199axonal fasciculation (GO:0007413)2.40195408
200pyrimidine-containing compound catabolic process (GO:0072529)2.40154571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.47640527
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.12307454
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.54081362
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.77111784
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.67649070
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.63029612
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.38630127
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29947328
9E2F7_22180533_ChIP-Seq_HELA_Human3.27211829
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.00734475
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96362578
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.90679055
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.74368906
14EZH2_22144423_ChIP-Seq_EOC_Human2.71972659
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.70552176
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63173685
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56818259
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.53906848
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.48524198
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.44633756
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.32598907
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.30664630
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28457292
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26688274
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.26313071
26PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23307248
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15621878
28GABP_19822575_ChIP-Seq_HepG2_Human2.15252509
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13220885
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.12164509
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.10113224
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09685510
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07777125
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98561824
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.88100974
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87402503
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85058438
38SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.82552826
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79721304
40XRN2_22483619_ChIP-Seq_HELA_Human1.77513460
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.75334537
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70988730
43SCL_19346495_ChIP-Seq_HPC-7_Human1.69669356
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68187109
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67838028
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.66766493
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65967802
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64581117
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.64001550
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61520244
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60138426
52SPI1_23547873_ChIP-Seq_NB4_Human1.59985951
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.56662546
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56084883
55ELK1_19687146_ChIP-ChIP_HELA_Human1.54719910
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54190967
57FOXP1_21924763_ChIP-Seq_HESCs_Human1.54175285
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.53732359
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48590031
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48410417
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.48202289
62* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47305622
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.47104903
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46699801
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46153536
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46095731
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.44421905
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44151740
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.43836596
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43592494
71IGF1R_20145208_ChIP-Seq_DFB_Human1.42942711
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42670550
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42197155
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41612820
75P53_22387025_ChIP-Seq_ESCs_Mouse1.40884851
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40366201
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39892419
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39745742
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38304247
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38180232
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.37493119
82TTF2_22483619_ChIP-Seq_HELA_Human1.37461664
83RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37435516
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36923354
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36708435
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33951141
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.33763289
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33464364
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.33092505
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.32151231
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31920854
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31766179
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31460806
94BCL6_27268052_Chip-Seq_Bcells_Human1.31208531
95* DCP1A_22483619_ChIP-Seq_HELA_Human1.30351804
96MYC_18555785_ChIP-Seq_MESCs_Mouse1.30081346
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.28281979
98CTCF_27219007_Chip-Seq_Bcells_Human1.27617563
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27511075
100* VDR_23849224_ChIP-Seq_CD4+_Human1.27323512
101GBX2_23144817_ChIP-Seq_PC3_Human1.26622367
102ZFX_18555785_Chip-Seq_ESCs_Mouse1.26560140
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25207331
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24595246
105PU1_27457419_Chip-Seq_LIVER_Mouse1.24550263
106KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24140274
107P300_18555785_Chip-Seq_ESCs_Mouse1.23586052
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.23028797
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22149558
110P68_20966046_ChIP-Seq_HELA_Human1.21605505
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.21386386
112SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19884861
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.19884710
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.18188328
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17599575
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17554871
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16841711
118FOXP3_21729870_ChIP-Seq_TREG_Human1.15912874
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14339317
120ZNF274_21170338_ChIP-Seq_K562_Hela1.14149469
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13740148
122YY1_22570637_ChIP-Seq_MALME-3M_Human1.13396414
123KLF4_18555785_Chip-Seq_ESCs_Mouse1.13151203
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12560119
125* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11910232
126GABP_17652178_ChIP-ChIP_JURKAT_Human1.11714014
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11477742
128CTCF_18555785_Chip-Seq_ESCs_Mouse1.11175721
129PU_27001747_Chip-Seq_BMDM_Mouse1.10914945
130REST_21632747_ChIP-Seq_MESCs_Mouse1.10807821
131ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10375489
132NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10311098
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10100669
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10053167
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10030324
136CBX2_27304074_Chip-Seq_ESCs_Mouse1.09921778
137CIITA_25753668_ChIP-Seq_RAJI_Human1.09134395
138PHF8_20622854_ChIP-Seq_HELA_Human1.08399537
139KDM5A_27292631_Chip-Seq_BREAST_Human1.08306020
140GATA1_22025678_ChIP-Seq_K562_Human1.08152419
141E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07806427
142CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07350800
143RUNX_20019798_ChIP-Seq_JUKART_Human1.04878882
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03162972
145EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02450062
146ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01492881
147IRF1_19129219_ChIP-ChIP_H3396_Human1.00614788
148GATA3_26560356_Chip-Seq_TH2_Human1.00249132
149RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00243194
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99918534
151RARB_24833708_ChIP-Seq_LIVER_Mouse0.99206500
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99200533
153ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99128358
154RARA_24833708_ChIP-Seq_LIVER_Mouse0.98859733
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.98560660
156EED_16625203_ChIP-ChIP_MESCs_Mouse0.98470448
157HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98358143
158MYC_18940864_ChIP-ChIP_HL60_Human0.98278539
159MYB_26560356_Chip-Seq_TH2_Human0.98236636
160CRX_20693478_ChIP-Seq_RETINA_Mouse0.97822552
161CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97539475
162PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96667666
163TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96464211
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96398482
165P300_19829295_ChIP-Seq_ESCs_Human0.96253127
166SA1_27219007_Chip-Seq_ERYTHROID_Human0.95874461
167BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95824201
168E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95406497
169EST1_17652178_ChIP-ChIP_JURKAT_Human0.95346658
170EGR1_19374776_ChIP-ChIP_THP-1_Human0.95183470
171CTCF_20526341_ChIP-Seq_ESCs_Human0.93559081
172EZH2_27294783_Chip-Seq_ESCs_Mouse0.93160975
173CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92684390
174* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92177086
175PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91915099
176SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90910880
177RNF2_27304074_Chip-Seq_NSC_Mouse0.90220326
178CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89521368
179IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89470291
180BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88775325
181RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88654601
182SA1_27219007_Chip-Seq_Bcells_Human0.88335083
183PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88175601
184GATA1_26923725_Chip-Seq_HPCs_Mouse0.88041466
185FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87548131
186OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87173000
187CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86773953
188SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86668015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.82916040
2MP0002837_dystrophic_cardiac_calcinosis4.27533577
3MP0009785_altered_susceptibility_to3.98952399
4MP0002148_abnormal_hypersensitivity_rea3.90190010
5MP0002653_abnormal_ependyma_morphology3.89398910
6MP0001529_abnormal_vocalization3.62448043
7MP0008789_abnormal_olfactory_epithelium3.42676179
8MP0005671_abnormal_response_to3.39058731
9MP0003646_muscle_fatigue3.21852319
10MP0003122_maternal_imprinting3.13369059
11MP0005394_taste/olfaction_phenotype3.09278729
12MP0005499_abnormal_olfactory_system3.09278729
13MP0003724_increased_susceptibility_to3.05575247
14MP0002419_abnormal_innate_immunity2.82208091
15MP0003436_decreased_susceptibility_to2.78781474
16MP0005000_abnormal_immune_tolerance2.75450073
17MP0005025_abnormal_response_to2.72789458
18MP0006276_abnormal_autonomic_nervous2.51209939
19MP0005387_immune_system_phenotype2.50936051
20MP0001790_abnormal_immune_system2.50936051
21MP0002452_abnormal_antigen_presenting2.40035376
22MP0002723_abnormal_immune_serum2.26357042
23MP0004782_abnormal_surfactant_physiolog2.23763281
24MP0000685_abnormal_immune_system2.23136411
25MP0000566_synostosis2.21389533
26MP0001800_abnormal_humoral_immune2.21356022
27MP0003121_genomic_imprinting2.19497394
28MP0006082_CNS_inflammation2.13585568
29MP0004133_heterotaxia2.10911816
30MP0001819_abnormal_immune_cell2.09795111
31MP0002420_abnormal_adaptive_immunity2.05792349
32MP0005310_abnormal_salivary_gland2.02394238
33MP0002132_abnormal_respiratory_system2.00683807
34MP0002876_abnormal_thyroid_physiology2.00420593
35MP0002277_abnormal_respiratory_mucosa1.98119552
36MP0009764_decreased_sensitivity_to1.95955381
37MP0000049_abnormal_middle_ear1.94750101
38MP0003123_paternal_imprinting1.93642813
39MP0008057_abnormal_DNA_replication1.91275374
40MP0008058_abnormal_DNA_repair1.81668615
41MP0003186_abnormal_redox_activity1.80172034
42MP0000778_abnormal_nervous_system1.75350567
43MP0002822_catalepsy1.73548742
44MP0004859_abnormal_synaptic_plasticity1.72325169
45MP0006292_abnormal_olfactory_placode1.71046750
46MP0009697_abnormal_copulation1.67814912
47MP0004142_abnormal_muscle_tone1.67796943
48MP0001485_abnormal_pinna_reflex1.62772212
49MP0002736_abnormal_nociception_after1.61711729
50MP0008877_abnormal_DNA_methylation1.61127225
51MP0002396_abnormal_hematopoietic_system1.60241164
52MP0002405_respiratory_system_inflammati1.57882501
53MP0009333_abnormal_splenocyte_physiolog1.57452334
54MP0000015_abnormal_ear_pigmentation1.57229686
55MP0002163_abnormal_gland_morphology1.54856246
56MP0000716_abnormal_immune_system1.52725592
57MP0001845_abnormal_inflammatory_respons1.48686890
58MP0001968_abnormal_touch/_nociception1.48091742
59MP0001986_abnormal_taste_sensitivity1.47940005
60MP0002398_abnormal_bone_marrow1.47822421
61MP0005171_absent_coat_pigmentation1.46210833
62MP0009384_cardiac_valve_regurgitation1.43654960
63MP0010386_abnormal_urinary_bladder1.43045190
64MP0004510_myositis1.42416993
65MP0010155_abnormal_intestine_physiology1.41865794
66MP0003763_abnormal_thymus_physiology1.41777883
67MP0005464_abnormal_platelet_physiology1.40909043
68MP0003448_altered_tumor_morphology1.38628241
69MP0006036_abnormal_mitochondrial_physio1.38129211
70MP0001533_abnormal_skeleton_physiology1.36929401
71MP0001853_heart_inflammation1.35705769
72MP0004270_analgesia1.33407619
73MP0001188_hyperpigmentation1.30720978
74MP0005379_endocrine/exocrine_gland_phen1.27469189
75MP0000751_myopathy1.26951171
76MP0003567_abnormal_fetal_cardiomyocyte1.26169948
77MP0005645_abnormal_hypothalamus_physiol1.26078905
78MP0000681_abnormal_thyroid_gland1.25579072
79MP0002272_abnormal_nervous_system1.24234997
80MP0002429_abnormal_blood_cell1.23767399
81MP0004742_abnormal_vestibular_system1.23426088
82MP0002006_tumorigenesis1.21965370
83MP0008260_abnormal_autophagy1.21275159
84MP0010030_abnormal_orbit_morphology1.20783846
85MP0000372_irregular_coat_pigmentation1.19374413
86MP0002557_abnormal_social/conspecific_i1.19146866
87MP0006035_abnormal_mitochondrial_morpho1.18776600
88MP0010094_abnormal_chromosome_stability1.16765625
89MP0002638_abnormal_pupillary_reflex1.16725954
90MP0005423_abnormal_somatic_nervous1.15559299
91MP0008469_abnormal_protein_level1.14593675
92MP0003942_abnormal_urinary_system1.14397148
93MP0005360_urolithiasis1.12782224
94MP0002734_abnormal_mechanical_nocicepti1.12333335
95MP0001984_abnormal_olfaction1.12250358
96MP0003941_abnormal_skin_development1.10432336
97MP0004811_abnormal_neuron_physiology1.10259320
98MP0003693_abnormal_embryo_hatching1.08955670
99MP0000858_altered_metastatic_potential1.07728125
100MP0002751_abnormal_autonomic_nervous1.05888200
101MP0005174_abnormal_tail_pigmentation1.05852955
102MP0002210_abnormal_sex_determination1.05247037
103MP0000689_abnormal_spleen_morphology1.05212745
104MP0009053_abnormal_anal_canal1.04922123
105MP0002733_abnormal_thermal_nociception1.04249714
106MP0001545_abnormal_hematopoietic_system1.03234012
107MP0005397_hematopoietic_system_phenotyp1.03234012
108MP0002722_abnormal_immune_system1.02941846
109MP0000955_abnormal_spinal_cord1.02506865
110MP0009046_muscle_twitch1.01682306
111MP0000343_altered_response_to1.01273651
112MP0002063_abnormal_learning/memory/cond1.00854006
113MP0002095_abnormal_skin_pigmentation1.00760172
114MP0001119_abnormal_female_reproductive0.99968508
115MP0001905_abnormal_dopamine_level0.99300169
116MP0008007_abnormal_cellular_replicative0.98709923
117MP0003879_abnormal_hair_cell0.98488658
118MP0005075_abnormal_melanosome_morpholog0.98221771
119MP0005390_skeleton_phenotype0.97605639
120MP0002752_abnormal_somatic_nervous0.97176861
121MP0000026_abnormal_inner_ear0.95837084
122MP0003635_abnormal_synaptic_transmissio0.95831279
123MP0009840_abnormal_foam_cell0.94858678
124MP0002998_abnormal_bone_remodeling0.94628580
125MP0000569_abnormal_digit_pigmentation0.93887013
126MP0001293_anophthalmia0.92908859
127MP0002138_abnormal_hepatobiliary_system0.92830685
128MP0001970_abnormal_pain_threshold0.92766267
129MP0002067_abnormal_sensory_capabilities0.92360727
130MP0003136_yellow_coat_color0.91501256
131MP0002882_abnormal_neuron_morphology0.90991926
132MP0000358_abnormal_cell_content/0.89298112
133MP0000631_abnormal_neuroendocrine_gland0.88799312
134MP0001963_abnormal_hearing_physiology0.88618168
135MP0001346_abnormal_lacrimal_gland0.86643584
136MP0000013_abnormal_adipose_tissue0.86068326
137MP0000490_abnormal_crypts_of0.85350667
138MP0005646_abnormal_pituitary_gland0.85274495
139MP0002909_abnormal_adrenal_gland0.84917869
140MP0003119_abnormal_digestive_system0.84209011
141MP0002152_abnormal_brain_morphology0.83532281
142MP0002229_neurodegeneration0.83391239
143MP0004808_abnormal_hematopoietic_stem0.82942337
144MP0002572_abnormal_emotion/affect_behav0.81784983
145MP0003011_delayed_dark_adaptation0.81141406
146MP0003111_abnormal_nucleus_morphology0.81128752
147MP0003938_abnormal_ear_development0.80136609
148MP0000678_abnormal_parathyroid_gland0.78443590
149MP0003880_abnormal_central_pattern0.77828051
150MP0005084_abnormal_gallbladder_morpholo0.76481824
151MP0000750_abnormal_muscle_regeneration0.76160052
152MP0001145_abnormal_male_reproductive0.75791315
153MP0003787_abnormal_imprinting0.75412529
154MP0002938_white_spotting0.74894610
155MP0003937_abnormal_limbs/digits/tail_de0.74796460
156MP0002184_abnormal_innervation0.74499306
157MP0001929_abnormal_gametogenesis0.74114316
158MP0009745_abnormal_behavioral_response0.73945830
159MP0002064_seizures0.73541515
160MP0003329_amyloid_beta_deposits0.73402660
161MP0004147_increased_porphyrin_level0.73247858
162MP0009763_increased_sensitivity_to0.72510783
163MP0000653_abnormal_sex_gland0.72111993
164MP0006054_spinal_hemorrhage0.71625161
165MP0009765_abnormal_xenobiotic_induced0.71455087
166MP0003698_abnormal_male_reproductive0.71022257
167MP0002139_abnormal_hepatobiliary_system0.70008585
168MP0002177_abnormal_outer_ear0.69765308
169MP0009250_abnormal_appendicular_skeleto0.69330806
170MP0008775_abnormal_heart_ventricle0.69317905
171MP0004130_abnormal_muscle_cell0.68396528
172MP0000703_abnormal_thymus_morphology0.68205306
173MP0002693_abnormal_pancreas_physiology0.68167437
174MP0002160_abnormal_reproductive_system0.67989396
175MP0003195_calcinosis0.67766687
176MP0003943_abnormal_hepatobiliary_system0.67620421
177MP0005551_abnormal_eye_electrophysiolog0.67387412
178MP0004924_abnormal_behavior0.67350181
179MP0001764_abnormal_homeostasis0.67145583
180MP0002102_abnormal_ear_morphology0.65556193
181MP0001186_pigmentation_phenotype0.64032406
182MP0003077_abnormal_cell_cycle0.63703670
183MP0003191_abnormal_cellular_cholesterol0.60522458
184MP0000516_abnormal_urinary_system0.60330017
185MP0005367_renal/urinary_system_phenotyp0.60330017
186MP0005389_reproductive_system_phenotype0.59925502

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.23876422
2Recurrent bacterial skin infections (HP:0005406)4.74719632
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.55853924
4Eczematoid dermatitis (HP:0000976)4.36694239
5Chromsome breakage (HP:0040012)4.35683136
6Optic neuritis (HP:0100653)4.10101258
7Retrobulbar optic neuritis (HP:0100654)4.10101258
8Prostate neoplasm (HP:0100787)4.08056774
9Hyperglycinemia (HP:0002154)3.76452904
10Acute necrotizing encephalopathy (HP:0006965)3.71631547
11Polyphagia (HP:0002591)3.70893399
12Myositis (HP:0100614)3.69074012
13Abnormal mitochondria in muscle tissue (HP:0008316)3.62782941
14Increased IgM level (HP:0003496)3.54229898
15Orchitis (HP:0100796)3.53477319
16Hepatocellular necrosis (HP:0001404)3.41835751
17Acute encephalopathy (HP:0006846)3.39797252
18Mediastinal lymphadenopathy (HP:0100721)3.38081107
19Recurrent gram-negative bacterial infections (HP:0005420)3.23913941
20Myokymia (HP:0002411)3.22125260
21Mitochondrial inheritance (HP:0001427)3.21905769
22Recurrent skin infections (HP:0001581)3.12408790
23Abnormality of macrophages (HP:0004311)3.11467741
24Hepatic necrosis (HP:0002605)3.06673950
25Recurrent cutaneous fungal infections (HP:0011370)3.06520642
26Chronic mucocutaneous candidiasis (HP:0002728)3.06520642
27Abnormality of the labia minora (HP:0012880)3.06505388
28Increased CSF lactate (HP:0002490)3.00535758
29Agnosia (HP:0010524)2.97430709
30Petechiae (HP:0000967)2.92749663
31Gingivitis (HP:0000230)2.88966234
32Hand muscle atrophy (HP:0009130)2.86338328
33Recurrent fungal infections (HP:0002841)2.85959783
34Progressive macrocephaly (HP:0004481)2.84806274
35Renal Fanconi syndrome (HP:0001994)2.84553626
36Recurrent pneumonia (HP:0006532)2.77834523
37Abnormality of the renal collecting system (HP:0004742)2.77273303
38Synostosis involving the elbow (HP:0003938)2.74580370
39Humeroradial synostosis (HP:0003041)2.74580370
40Obstructive lung disease (HP:0006536)2.73486438
41Chronic obstructive pulmonary disease (HP:0006510)2.73486438
42Elevated erythrocyte sedimentation rate (HP:0003565)2.72374261
43Basal ganglia calcification (HP:0002135)2.72010731
44Molar tooth sign on MRI (HP:0002419)2.70526193
45Abnormality of midbrain morphology (HP:0002418)2.70526193
46Failure to thrive in infancy (HP:0001531)2.69119078
47Gait imbalance (HP:0002141)2.68754280
48Abnormality of the prostate (HP:0008775)2.67125722
49Vasculitis (HP:0002633)2.66007167
50Keratoconjunctivitis sicca (HP:0001097)2.64498539
51Type I transferrin isoform profile (HP:0003642)2.63816682
52Nephrogenic diabetes insipidus (HP:0009806)2.63744719
53Keratoconjunctivitis (HP:0001096)2.55768259
54Clubbing of toes (HP:0100760)2.55390309
55Poor suck (HP:0002033)2.54506201
56Medial flaring of the eyebrow (HP:0010747)2.49852508
57Congenital primary aphakia (HP:0007707)2.49539890
58Nephronophthisis (HP:0000090)2.49216779
59Periodontitis (HP:0000704)2.48792360
60White forelock (HP:0002211)2.46635068
61Duplicated collecting system (HP:0000081)2.46579406
62Increased intramyocellular lipid droplets (HP:0012240)2.45527224
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.44605619
64Abnormal hair whorl (HP:0010721)2.43738826
65Cerebral edema (HP:0002181)2.43364564
66Hypoplastic pelvis (HP:0008839)2.43052788
67Retinal dysplasia (HP:0007973)2.39905016
68Short 1st metacarpal (HP:0010034)2.39717787
69Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.39717787
70Reduced antithrombin III activity (HP:0001976)2.39098153
71Increased muscle lipid content (HP:0009058)2.35957536
72Short tibia (HP:0005736)2.35548211
73Birth length less than 3rd percentile (HP:0003561)2.34745024
74Ectopic kidney (HP:0000086)2.34451915
75Recurrent lower respiratory tract infections (HP:0002783)2.33877225
76Rib fusion (HP:0000902)2.29109456
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.28616137
78True hermaphroditism (HP:0010459)2.27954925
79Patchy hypopigmentation of hair (HP:0011365)2.27323972
80Lipid accumulation in hepatocytes (HP:0006561)2.25998850
81Vacuolated lymphocytes (HP:0001922)2.25596991
82Meningitis (HP:0001287)2.25270654
83Abnormality of DNA repair (HP:0003254)2.24659844
84Cholecystitis (HP:0001082)2.24061203
85Abnormal gallbladder physiology (HP:0012438)2.24061203
86Stomatitis (HP:0010280)2.23483696
87Meckel diverticulum (HP:0002245)2.23416716
88Alveolar cell carcinoma (HP:0006519)2.22894442
89Spinal cord lesions (HP:0100561)2.20798064
90Syringomyelia (HP:0003396)2.20798064
91Reticulocytopenia (HP:0001896)2.20705725
92Progressive microcephaly (HP:0000253)2.17730821
93Pulmonary infiltrates (HP:0002113)2.17308115
94Abnormality of the ileum (HP:0001549)2.16875507
95Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16521941
96Type 2 muscle fiber atrophy (HP:0003554)2.16228074
97Optic nerve coloboma (HP:0000588)2.15359485
98Lactic acidosis (HP:0003128)2.14760029
99Abnormality of glycine metabolism (HP:0010895)2.13809003
100Abnormality of serine family amino acid metabolism (HP:0010894)2.13809003
101Abnormality of the preputium (HP:0100587)2.13655737
102Abnormality of chromosome stability (HP:0003220)2.13576937
103Prolonged neonatal jaundice (HP:0006579)2.13390502
104Anomalous pulmonary venous return (HP:0010772)2.12862075
105Encephalitis (HP:0002383)2.12418469
106Abnormality of the 1st metacarpal (HP:0010009)2.11399755
107Autoimmune thrombocytopenia (HP:0001973)2.11288772
108Increased hepatocellular lipid droplets (HP:0006565)2.07881140
109Abnormality of the proximal phalanges of the hand (HP:0009834)2.07624291
110Bile duct proliferation (HP:0001408)2.06465011
111Abnormal biliary tract physiology (HP:0012439)2.06465011
112Hypergammaglobulinemia (HP:0010702)2.06308325
113Long foot (HP:0001833)2.05575450
114Methylmalonic aciduria (HP:0012120)2.04835404
115Exercise intolerance (HP:0003546)2.03736953
116Recurrent viral infections (HP:0004429)2.02186441
117Hypothermia (HP:0002045)2.01538318
118Renal cortical cysts (HP:0000803)2.00111393
119Cortical dysplasia (HP:0002539)1.98820060
120Lissencephaly (HP:0001339)1.98349575
121Glomerulopathy (HP:0100820)1.95461194
122Atrophy/Degeneration involving motor neurons (HP:0007373)1.95083716
123Abnormality of incisor morphology (HP:0011063)1.94984210
124Cerebral palsy (HP:0100021)1.94453200
125Abnormal eating behavior (HP:0100738)1.94439262
126Fibular aplasia (HP:0002990)1.93780326
127Upper limb amyotrophy (HP:0009129)1.92489223
128Distal upper limb amyotrophy (HP:0007149)1.92489223
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.91275703
130Pachygyria (HP:0001302)1.90871667
131Optic disc pallor (HP:0000543)1.90870084
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.89692758
133Abnormality of male internal genitalia (HP:0000022)1.89510715
134Bone marrow hypocellularity (HP:0005528)1.89438261
135Cheilitis (HP:0100825)1.89223341
136Amyotrophic lateral sclerosis (HP:0007354)1.88556215
137Neutropenia (HP:0001875)1.88225141
138Thrombocytosis (HP:0001894)1.88077396
139Keratitis (HP:0000491)1.87843294
140Abnormality of the metopic suture (HP:0005556)1.87514700
141Opisthotonus (HP:0002179)1.87046703
142Hyperglycinuria (HP:0003108)1.86882447
143Poikiloderma (HP:0001029)1.86563008
144Abnormality of the pulmonary veins (HP:0011718)1.86132837
145Supernumerary spleens (HP:0009799)1.85938180
146Asplenia (HP:0001746)1.85649427
147Hemoptysis (HP:0002105)1.85623921
148Stomach cancer (HP:0012126)1.84790127
149Colon cancer (HP:0003003)1.84662274
150Septo-optic dysplasia (HP:0100842)1.84515215
151Oligomenorrhea (HP:0000876)1.83965899
152Specific learning disability (HP:0001328)1.83799168
153Osteomalacia (HP:0002749)1.83110094
154Neoplasm of the tracheobronchial system (HP:0100552)1.81279707
155Increased serum lactate (HP:0002151)1.81264297
156Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81126190
157Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81126190
158Agitation (HP:0000713)1.80947814
159Spastic tetraplegia (HP:0002510)1.80942559
160Agammaglobulinemia (HP:0004432)1.80455651
161Respiratory failure (HP:0002878)1.79766133
162Pancreatic fibrosis (HP:0100732)1.79404690
163Sclerocornea (HP:0000647)1.79086941
164IgG deficiency (HP:0004315)1.79078247
165Emotional lability (HP:0000712)1.78744878
166Abnormality of the renal medulla (HP:0100957)1.78453354
167Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.78409189
168Gangrene (HP:0100758)1.78337258
169Premature loss of primary teeth (HP:0006323)1.78059208
170Flat capital femoral epiphysis (HP:0003370)1.77951343
171Leukocytosis (HP:0001974)1.77105623
172Purpura (HP:0000979)1.77098793
173Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76430439
174Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76351325
175Dicarboxylic aciduria (HP:0003215)1.76351325
176Prominent metopic ridge (HP:0005487)1.75729889
177Limb dystonia (HP:0002451)1.75351669
178Osteomyelitis (HP:0002754)1.74599055
179Conical tooth (HP:0000698)1.73560878
180Urticaria (HP:0001025)1.72369357
181Thick nail (HP:0001805)1.70061697
182Abnormal glycosylation (HP:0012345)1.69444073
183Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69444073
184Abnormal protein N-linked glycosylation (HP:0012347)1.69444073
185Abnormal protein glycosylation (HP:0012346)1.69444073
186Hypoplasia of the fovea (HP:0007750)1.69317366
187Aplasia/Hypoplasia of the fovea (HP:0008060)1.69317366
188Prolonged bleeding time (HP:0003010)1.69092108
189Muscle fiber atrophy (HP:0100295)1.68150487
190Chronic hepatic failure (HP:0100626)1.65757995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.41739235
2BCKDK4.04496441
3IRAK43.39119732
4MAP4K23.22600036
5IRAK33.10689399
6ZAK3.04519714
7CDK193.02400005
8TXK2.93404451
9DYRK22.91340634
10VRK22.81542122
11PBK2.62587122
12BMPR22.49321241
13TESK12.38725384
14LIMK12.32890363
15SIK22.28845998
16MAP3K112.17942726
17MAP3K92.14710583
18IKBKB2.11542420
19RIPK42.09984348
20MARK12.04348968
21CSNK1G32.02403761
22ERBB32.01753173
23TESK21.99611299
24BLK1.97747737
25IKBKE1.91163733
26JAK31.89878381
27ADRBK21.89604934
28CSNK1G21.88939731
29YES11.84218791
30WNK31.82111101
31EIF2AK21.81910021
32PDK21.80060373
33SIK31.76550999
34PLK41.75219803
35DYRK31.73753294
36INSRR1.69717432
37TRPM71.68096081
38TBK11.67029342
39PIK3CG1.65939484
40CSNK1G11.65133076
41CLK11.64339785
42TEC1.63467395
43CHUK1.55878851
44PIM21.55441201
45ARAF1.54227991
46CSNK1A1L1.50298326
47DYRK1B1.40778149
48BCR1.40367740
49TYK21.38103362
50CASK1.35875097
51TRIM281.32645380
52MAP3K41.31514238
53STK41.29876721
54STK241.25730813
55AURKA1.24530111
56KIT1.22824142
57STK161.22368478
58PRPF4B1.21228720
59MINK11.19988452
60MKNK21.19661932
61BMPR1B1.18274953
62AKT31.16178629
63PRKD21.15822968
64SGK21.15411941
65EPHB21.13623088
66PIM11.07275569
67GRK71.07221517
68BTK1.04788990
69IRAK11.03203513
70MKNK11.03172812
71MAP2K71.01940645
72NEK91.00487603
73PRKCG0.99149376
74STK38L0.98742600
75NEK60.98686961
76MAP2K40.94062676
77MAP3K120.93273226
78CCNB10.91422048
79NTRK30.90938722
80TNIK0.90881190
81DYRK1A0.89919807
82NME20.88288694
83ATR0.87284913
84SYK0.87084126
85PINK10.85503347
86MAPK150.83316066
87LYN0.82502471
88GRK10.81757009
89VRK10.81268712
90SIK10.79693293
91NLK0.78794335
92BUB10.78781543
93JAK10.77541775
94SRPK10.75848702
95PLK20.75802816
96NUAK10.74918452
97NTRK20.74638317
98CDK80.73448181
99CDK11A0.73193503
100CDK140.73015364
101PHKG10.72425742
102PHKG20.72425742
103RPS6KA40.72422309
104EPHA40.72224457
105NME10.70731708
106MUSK0.70529296
107DAPK30.68783459
108PLK10.67969216
109EIF2AK30.67445748
110TSSK60.67299889
111MAP2K20.65102797
112MAPKAPK50.64364996
113EPHA30.63880773
114DAPK10.62980559
115EPHA20.62832542
116TAOK20.62798333
117ZAP700.62226506
118BRSK20.61030833
119TAOK10.60753277
120PRKCZ0.59969230
121CDK50.59310843
122MST40.58256913
123STK380.58029640
124CDK180.56597686
125PAK10.56262056
126PRKCI0.56047397
127CDK150.55664685
128CDK30.54666481
129PKN10.53697306
130PRKCD0.52269639
131PRKACA0.52122638
132SGK4940.51519766
133SGK2230.51519766
134CSK0.51027316
135STK30.50993090
136BRSK10.50544529
137CAMK10.50200513
138MAP4K10.49880809
139ABL20.49689680
140TIE10.49131336
141MAPK130.48932805
142FLT30.46608484
143RPS6KA60.46217606
144BRAF0.45995122
145LCK0.45394919
146WNK40.44045678
147RAF10.43926220
148LRRK20.42992025
149EPHB10.42643260
150HCK0.42336980
151IRAK20.41287878
152RPS6KB10.41157202
153KDR0.41040294
154MARK20.39973031
155PRKD30.39950072
156CAMKK10.39103792
157CSNK2A10.38787081
158AKT20.38744939
159PLK30.37681395
160PAK30.37524094
161CSNK2A20.37125207
162CAMKK20.36565596
163MAP3K50.35959656
164RPS6KA50.35587652
165BRD40.35544633
166SGK30.35339318
167RPS6KL10.34978001
168RPS6KC10.34978001
169CSNK1A10.34408368
170RPS6KA20.33796256
171PASK0.32364387
172ATM0.32327597
173CAMK2G0.29612441

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.55626848
2Graft-versus-host disease_Homo sapiens_hsa053323.51961956
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.36358688
4Sulfur relay system_Homo sapiens_hsa041223.33189769
5Allograft rejection_Homo sapiens_hsa053303.29266849
6Parkinsons disease_Homo sapiens_hsa050122.81311723
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.58385732
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.46875667
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40831456
10Type I diabetes mellitus_Homo sapiens_hsa049402.37035399
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.32105405
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30675917
13Leishmaniasis_Homo sapiens_hsa051402.29814888
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28508050
15Rheumatoid arthritis_Homo sapiens_hsa053232.27202668
16Fatty acid elongation_Homo sapiens_hsa000622.25999935
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22960207
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.19841230
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16087142
20Measles_Homo sapiens_hsa051622.13817949
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09156766
22Autoimmune thyroid disease_Homo sapiens_hsa053202.06664044
23Legionellosis_Homo sapiens_hsa051342.06412979
24NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00149668
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00127084
26Huntingtons disease_Homo sapiens_hsa050161.85398304
27Homologous recombination_Homo sapiens_hsa034401.80496526
28Fanconi anemia pathway_Homo sapiens_hsa034601.78647530
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.76149887
30Herpes simplex infection_Homo sapiens_hsa051681.74959627
31Influenza A_Homo sapiens_hsa051641.72334661
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.71664727
33Asthma_Homo sapiens_hsa053101.69643872
34Alzheimers disease_Homo sapiens_hsa050101.66242035
35Ribosome_Homo sapiens_hsa030101.59255901
36Biosynthesis of amino acids_Homo sapiens_hsa012301.59107271
37Carbon metabolism_Homo sapiens_hsa012001.57579576
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55807226
39Mismatch repair_Homo sapiens_hsa034301.54762044
40Primary immunodeficiency_Homo sapiens_hsa053401.53612231
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52540236
42Propanoate metabolism_Homo sapiens_hsa006401.52010579
43Pertussis_Homo sapiens_hsa051331.51353507
44Hematopoietic cell lineage_Homo sapiens_hsa046401.46524483
45Base excision repair_Homo sapiens_hsa034101.45264142
46Synaptic vesicle cycle_Homo sapiens_hsa047211.44393743
47Malaria_Homo sapiens_hsa051441.42789953
48Folate biosynthesis_Homo sapiens_hsa007901.42748174
49Tuberculosis_Homo sapiens_hsa051521.42645272
50Peroxisome_Homo sapiens_hsa041461.40175684
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38863384
52Proteasome_Homo sapiens_hsa030501.38603292
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38426706
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34842290
55DNA replication_Homo sapiens_hsa030301.33987482
56Osteoclast differentiation_Homo sapiens_hsa043801.32743129
57TNF signaling pathway_Homo sapiens_hsa046681.31315583
58Phagosome_Homo sapiens_hsa041451.31253966
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26197330
60Basal transcription factors_Homo sapiens_hsa030221.23485618
61Jak-STAT signaling pathway_Homo sapiens_hsa046301.23090896
62Nicotine addiction_Homo sapiens_hsa050331.22701683
63Antigen processing and presentation_Homo sapiens_hsa046121.22560011
64Butanoate metabolism_Homo sapiens_hsa006501.21372981
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21205156
66Staphylococcus aureus infection_Homo sapiens_hsa051501.21096544
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20165046
68Pyruvate metabolism_Homo sapiens_hsa006201.19162348
69Non-homologous end-joining_Homo sapiens_hsa034501.17881938
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17672196
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17414333
72African trypanosomiasis_Homo sapiens_hsa051431.15688432
73Fatty acid metabolism_Homo sapiens_hsa012121.14749010
74Salmonella infection_Homo sapiens_hsa051321.12894963
75Cardiac muscle contraction_Homo sapiens_hsa042601.12684984
76Cysteine and methionine metabolism_Homo sapiens_hsa002701.11385468
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07408786
78Primary bile acid biosynthesis_Homo sapiens_hsa001201.07313960
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06436236
80Apoptosis_Homo sapiens_hsa042101.05240485
81Fructose and mannose metabolism_Homo sapiens_hsa000511.04909194
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99642406
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99436888
84Phototransduction_Homo sapiens_hsa047440.98696430
85Chemokine signaling pathway_Homo sapiens_hsa040620.96750599
86Toxoplasmosis_Homo sapiens_hsa051450.93948678
87RNA polymerase_Homo sapiens_hsa030200.93544447
88Protein export_Homo sapiens_hsa030600.91233528
89Metabolic pathways_Homo sapiens_hsa011000.88792906
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88613128
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88318136
92Pentose phosphate pathway_Homo sapiens_hsa000300.88293134
93Pyrimidine metabolism_Homo sapiens_hsa002400.87957076
94Other glycan degradation_Homo sapiens_hsa005110.84760047
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84251424
96RNA degradation_Homo sapiens_hsa030180.83136033
97Nucleotide excision repair_Homo sapiens_hsa034200.81576983
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80802915
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79995186
100Fatty acid degradation_Homo sapiens_hsa000710.78903669
101Collecting duct acid secretion_Homo sapiens_hsa049660.78115781
102Glutathione metabolism_Homo sapiens_hsa004800.77676635
103Arginine and proline metabolism_Homo sapiens_hsa003300.76905648
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73531709
105beta-Alanine metabolism_Homo sapiens_hsa004100.72487391
106Arachidonic acid metabolism_Homo sapiens_hsa005900.71276271
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70484861
108Viral myocarditis_Homo sapiens_hsa054160.69828794
109GABAergic synapse_Homo sapiens_hsa047270.69047258
110Hepatitis B_Homo sapiens_hsa051610.68968340
111Axon guidance_Homo sapiens_hsa043600.67965382
112Hepatitis C_Homo sapiens_hsa051600.66335076
113p53 signaling pathway_Homo sapiens_hsa041150.66007783
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65203396
115Phenylalanine metabolism_Homo sapiens_hsa003600.65020698
116Cocaine addiction_Homo sapiens_hsa050300.64844781
117Sphingolipid metabolism_Homo sapiens_hsa006000.64536978
118Epstein-Barr virus infection_Homo sapiens_hsa051690.64110819
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64060499
120Lysosome_Homo sapiens_hsa041420.63519530
121Tyrosine metabolism_Homo sapiens_hsa003500.61923668
122Cell cycle_Homo sapiens_hsa041100.58716408
123Shigellosis_Homo sapiens_hsa051310.58302141
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55687062
125One carbon pool by folate_Homo sapiens_hsa006700.55300029
126Regulation of autophagy_Homo sapiens_hsa041400.53409389
127Prolactin signaling pathway_Homo sapiens_hsa049170.52106830
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50369027
129N-Glycan biosynthesis_Homo sapiens_hsa005100.49918749
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48912147
131Purine metabolism_Homo sapiens_hsa002300.48887145
132Dopaminergic synapse_Homo sapiens_hsa047280.48198967
133Selenocompound metabolism_Homo sapiens_hsa004500.48011429
134Steroid biosynthesis_Homo sapiens_hsa001000.46575993
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45741404
136AMPK signaling pathway_Homo sapiens_hsa041520.45572888
137Chemical carcinogenesis_Homo sapiens_hsa052040.44806483
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42231450
139Notch signaling pathway_Homo sapiens_hsa043300.42043768
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.40682563
141Arginine biosynthesis_Homo sapiens_hsa002200.40663460
142B cell receptor signaling pathway_Homo sapiens_hsa046620.39734982
143RNA transport_Homo sapiens_hsa030130.38230040
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.38030079
145Vibrio cholerae infection_Homo sapiens_hsa051100.37365916
146Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37340481
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37279205
148Basal cell carcinoma_Homo sapiens_hsa052170.36441535
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.36242012
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35679241
151Vitamin B6 metabolism_Homo sapiens_hsa007500.35223791
152HTLV-I infection_Homo sapiens_hsa051660.34687779
153Hedgehog signaling pathway_Homo sapiens_hsa043400.34099463
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33709740
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28520404
156Morphine addiction_Homo sapiens_hsa050320.27712202
157Maturity onset diabetes of the young_Homo sapiens_hsa049500.26923020
158Spliceosome_Homo sapiens_hsa030400.25573574
159Sulfur metabolism_Homo sapiens_hsa009200.24441393
160AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24027802
161Vitamin digestion and absorption_Homo sapiens_hsa049770.23807606
162Glycosaminoglycan degradation_Homo sapiens_hsa005310.23477694
163Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21750714
164Systemic lupus erythematosus_Homo sapiens_hsa053220.21438668
165Viral carcinogenesis_Homo sapiens_hsa052030.20979080
166Galactose metabolism_Homo sapiens_hsa000520.20667052
167FoxO signaling pathway_Homo sapiens_hsa040680.19230796
168T cell receptor signaling pathway_Homo sapiens_hsa046600.18174524
169Acute myeloid leukemia_Homo sapiens_hsa052210.17875690
170Oxidative phosphorylation_Homo sapiens_hsa001900.16857750
171Prion diseases_Homo sapiens_hsa050200.13791299

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