THBS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)8.97193565
2extracellular matrix assembly (GO:0085029)8.18466451
3skeletal muscle adaptation (GO:0043501)7.45108370
4collagen fibril organization (GO:0030199)7.43584994
5extracellular fibril organization (GO:0043206)6.98547423
6myelination in peripheral nervous system (GO:0022011)6.96171551
7peripheral nervous system axon ensheathment (GO:0032292)6.96171551
8myofibril assembly (GO:0030239)6.73102947
9fibril organization (GO:0097435)6.37729731
10cornea development in camera-type eye (GO:0061303)6.35070249
11bone trabecula formation (GO:0060346)6.17171805
12negative regulation of stress fiber assembly (GO:0051497)6.15213862
13sarcomere organization (GO:0045214)5.98567927
14sarcoplasmic reticulum calcium ion transport (GO:0070296)5.94912175
15skeletal muscle contraction (GO:0003009)5.83011678
16sequestering of extracellular ligand from receptor (GO:0035581)5.66663470
17negative regulation of Rho protein signal transduction (GO:0035024)5.59463343
18keratan sulfate biosynthetic process (GO:0018146)5.53486710
19actin filament-based movement (GO:0030048)5.51947607
20regulation of relaxation of muscle (GO:1901077)5.35114159
21striated muscle contraction (GO:0006941)5.26634676
22skin morphogenesis (GO:0043589)5.24360087
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.19001407
24endothelial cell morphogenesis (GO:0001886)5.18494687
25collagen metabolic process (GO:0032963)5.18020752
26collagen catabolic process (GO:0030574)4.93836388
27multicellular organismal macromolecule metabolic process (GO:0044259)4.91643265
28cardiac muscle contraction (GO:0060048)4.86731317
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.77213171
30keratan sulfate metabolic process (GO:0042339)4.71131571
31actomyosin structure organization (GO:0031032)4.68766692
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.67714934
33multicellular organismal metabolic process (GO:0044236)4.63642577
34multicellular organismal catabolic process (GO:0044243)4.59347283
35cardiac muscle hypertrophy (GO:0003300)4.52256882
36negative regulation of actin filament bundle assembly (GO:0032232)4.50269127
37response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.47380143
38regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.44106724
39neuronal ion channel clustering (GO:0045161)4.32768086
40negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.28412934
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.26756644
42striated muscle hypertrophy (GO:0014897)4.19530327
43response to inactivity (GO:0014854)4.17870550
44endodermal cell differentiation (GO:0035987)4.17483304
45regulation of actin filament-based movement (GO:1903115)4.15035108
46extracellular matrix disassembly (GO:0022617)4.12609818
47regulation of cell communication by electrical coupling (GO:0010649)4.10419423
48dermatan sulfate biosynthetic process (GO:0030208)4.08180094
49sulfur compound catabolic process (GO:0044273)4.06651670
50cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.06650404
51creatine metabolic process (GO:0006600)4.05448137
52muscle contraction (GO:0006936)4.03703034
53response to muscle activity (GO:0014850)3.96563553
54detection of molecule of bacterial origin (GO:0032490)3.91341003
55regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.88194817
56peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.86456094
57regulation of plasminogen activation (GO:0010755)3.86399387
58neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.83025454
59muscle hypertrophy (GO:0014896)3.79018341
60negative regulation of potassium ion transmembrane transport (GO:1901380)3.78940962
61muscle filament sliding (GO:0030049)3.78411981
62actin-myosin filament sliding (GO:0033275)3.78411981
63opsonization (GO:0008228)3.77092014
64dermatan sulfate metabolic process (GO:0030205)3.75187881
65muscle system process (GO:0003012)3.73892111
66complement activation, alternative pathway (GO:0006957)3.73065100
67negative regulation of heart growth (GO:0061117)3.70699772
68negative regulation of cardiac muscle tissue growth (GO:0055022)3.70699772
69adult heart development (GO:0007512)3.68180111
70positive regulation of p38MAPK cascade (GO:1900745)3.67914998
71cellular response to cadmium ion (GO:0071276)3.63394615
72cardiac muscle cell development (GO:0055013)3.62954610
73extracellular matrix organization (GO:0030198)3.62414286
74extracellular structure organization (GO:0043062)3.60964729
75positive regulation of focal adhesion assembly (GO:0051894)3.52538157
76positive regulation of cell junction assembly (GO:1901890)3.52538157
77peptidyl-proline hydroxylation (GO:0019511)3.52233925
78carnitine shuttle (GO:0006853)3.51084077
79cardiac cell development (GO:0055006)3.50003044
80cardiac muscle tissue morphogenesis (GO:0055008)3.49413242
81positive regulation of adherens junction organization (GO:1903393)3.44632274
82muscle tissue morphogenesis (GO:0060415)3.44323347
83regulation of mitochondrial depolarization (GO:0051900)3.43464698
84cardiac muscle hypertrophy in response to stress (GO:0014898)3.43113649
85muscle hypertrophy in response to stress (GO:0003299)3.43113649
86cardiac muscle adaptation (GO:0014887)3.43113649
87regulation of striated muscle contraction (GO:0006942)3.42139479
88chondrocyte proliferation (GO:0035988)3.40850529
89glycosaminoglycan catabolic process (GO:0006027)3.40491991
90striated muscle adaptation (GO:0014888)3.39832083
91non-canonical Wnt signaling pathway (GO:0035567)3.39131431
92paraxial mesoderm development (GO:0048339)3.38991862
93trabecula formation (GO:0060343)3.38588236
94cellular sodium ion homeostasis (GO:0006883)3.38046830
95regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.35665238
96cellular response to epinephrine stimulus (GO:0071872)3.35053993
97actin-mediated cell contraction (GO:0070252)3.31656384
98blood vessel maturation (GO:0001955)3.30274139
99myotube cell development (GO:0014904)3.29500828
100glycosaminoglycan biosynthetic process (GO:0006024)3.28533465
101regulation of complement activation (GO:0030449)3.27522430
102protein trimerization (GO:0070206)3.26030104
103cGMP-mediated signaling (GO:0019934)3.25016002
104cellular response to amino acid stimulus (GO:0071230)3.25001673
105regulation of the force of heart contraction (GO:0002026)3.24491269
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.24259855
107regulation of sequestering of triglyceride (GO:0010889)3.23905601
108aminoglycan biosynthetic process (GO:0006023)3.23117633
109cell adhesion mediated by integrin (GO:0033627)3.20966152
110fatty acid transmembrane transport (GO:1902001)3.20389794
111regulation of p38MAPK cascade (GO:1900744)3.19291391
112negative regulation of interleukin-8 production (GO:0032717)3.18076602
113muscle organ development (GO:0007517)3.18064438
114growth hormone secretion (GO:0030252)3.18039689
115skeletal muscle fiber development (GO:0048741)3.16641352
116virion attachment to host cell (GO:0019062)3.15241879
117adhesion of symbiont to host cell (GO:0044650)3.15241879
118muscle structure development (GO:0061061)3.14353397
119aminoglycan catabolic process (GO:0006026)3.14176912
120regulation of striated muscle cell apoptotic process (GO:0010662)3.12454642
121response to BMP (GO:0071772)3.11507287
122cellular response to BMP stimulus (GO:0071773)3.11507287
123response to epinephrine (GO:0071871)3.10822949
124regulation of Rho protein signal transduction (GO:0035023)3.09581063
125protein hydroxylation (GO:0018126)3.08622412
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05894076
127regulation of skeletal muscle contraction (GO:0014819)3.05725419
128ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.05135461
129regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.04826224
130regulation of cardiac muscle cell apoptotic process (GO:0010665)3.02671358
131barbed-end actin filament capping (GO:0051016)3.02252940
132muscle cell fate commitment (GO:0042693)3.02189950
133muscle fiber development (GO:0048747)2.99446878
134glomerular basement membrane development (GO:0032836)2.96896864
135skeletal muscle tissue development (GO:0007519)2.96624753
136negative regulation of chondrocyte differentiation (GO:0032331)2.94682857
137regulation of protein activation cascade (GO:2000257)2.93992038
138muscle cell cellular homeostasis (GO:0046716)2.93798284
139regulation of calcium ion transmembrane transport (GO:1903169)2.92795662
140regulation of calcium ion transmembrane transporter activity (GO:1901019)2.92795662
141regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.89039247
142plasma membrane repair (GO:0001778)2.88851494
143regulation of fibroblast migration (GO:0010762)2.88549525
144cell migration involved in heart development (GO:0060973)2.86731252
145muscle adaptation (GO:0043500)2.85530455
146negative regulation of cell-matrix adhesion (GO:0001953)2.83380725
147regulation of membrane repolarization (GO:0060306)2.82537835
148cardiac myofibril assembly (GO:0055003)2.81755499
149regulation of myoblast differentiation (GO:0045661)2.80921284
150positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.80498149
151striated muscle cell development (GO:0055002)2.79951383
152regulation of skeletal muscle cell differentiation (GO:2001014)2.78412249
153regulation of muscle system process (GO:0090257)2.78175379
154cell communication by electrical coupling (GO:0010644)2.76636658
155apoptotic cell clearance (GO:0043277)2.76072200
156short-term memory (GO:0007614)2.74119537
157negative regulation of complement activation (GO:0045916)2.73898940
158extracellular negative regulation of signal transduction (GO:1900116)2.73719913
159extracellular regulation of signal transduction (GO:1900115)2.73719913
160basement membrane organization (GO:0071711)2.73622821
161retina vasculature morphogenesis in camera-type eye (GO:0061299)2.72069418
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71197441
163positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.70760193
164regulation of tight junction assembly (GO:2000810)2.70181977
165glucan biosynthetic process (GO:0009250)2.69989553
166glycogen biosynthetic process (GO:0005978)2.69989553
167metanephric mesenchyme development (GO:0072075)2.69959404
168positive regulation of Rho protein signal transduction (GO:0035025)2.69667624
169fibroblast migration (GO:0010761)2.68799209
170NADH metabolic process (GO:0006734)2.67974236
171response to caffeine (GO:0031000)2.67537194
172regulation of heart rate (GO:0002027)2.64502064
173muscle cell development (GO:0055001)2.64292353
174cell communication involved in cardiac conduction (GO:0086065)2.62328984
175negative regulation of protein localization to cell surface (GO:2000009)2.61279467
176endocrine hormone secretion (GO:0060986)2.60190086
177regulation of muscle contraction (GO:0006937)2.59471849
178positive regulation of myotube differentiation (GO:0010831)2.56869003
179relaxation of cardiac muscle (GO:0055119)2.56312016
180regulation of cardiac muscle cell contraction (GO:0086004)2.56121724
181keratan sulfate catabolic process (GO:0042340)11.6858459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.13425778
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.10434993
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.69432422
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.96083615
5TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.94043370
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.84043160
7CLOCK_20551151_ChIP-Seq_293T_Human2.67410463
8* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.59785357
9GBX2_23144817_ChIP-Seq_PC3_Human2.54926581
10CJUN_26792858_Chip-Seq_BT549_Human2.33578559
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.26943336
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22908876
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20787437
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.18759016
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15420477
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14407155
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14350318
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11983776
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11983776
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.11633812
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07352379
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.06326385
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02961396
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.95991156
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92780329
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92052919
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.91701385
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90573052
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.90398716
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.90082303
31EGR1_19032775_ChIP-ChIP_M12_Human1.88027057
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.81862376
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81706547
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.76549248
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76303360
36DROSHA_22980978_ChIP-Seq_HELA_Human1.73523737
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.69772659
38* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66806477
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66100978
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64942111
41* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59483358
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59050199
43BRD4_25478319_ChIP-Seq_HGPS_Human1.57074048
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.54980973
45AR_21572438_ChIP-Seq_LNCaP_Human1.51094384
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48452545
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46406511
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45622484
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45622484
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.45528256
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.40763182
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.40763182
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.39021731
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37441036
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35104264
56SMC1_22415368_ChIP-Seq_MEFs_Mouse1.34498135
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.33819045
58PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.29858442
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29381502
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.27866704
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27860532
62TP53_16413492_ChIP-PET_HCT116_Human1.27622551
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27237972
64JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26599003
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26238299
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23993142
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.22806837
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.22364354
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.21671251
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21017646
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20975812
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20797843
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19884448
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.19168571
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18717799
76TP53_18474530_ChIP-ChIP_U2OS_Human1.18093797
77EZH2_22144423_ChIP-Seq_EOC_Human1.18031766
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17937702
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17871031
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17449392
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16754501
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16754501
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16689558
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15932178
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15855215
86VDR_22108803_ChIP-Seq_LS180_Human1.15426116
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15103852
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14740019
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13824930
90* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13272464
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.12195348
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11993662
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10906854
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10509198
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09421179
96KDM2B_26808549_Chip-Seq_K562_Human1.09357997
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09197809
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07465052
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06853567
100IGF1R_20145208_ChIP-Seq_DFB_Human1.06659035
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.06457625
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06204029
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05209109
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03920651
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03166683
106ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03135699
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.01675478
108SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01350620
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01143333
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00417167
111GATA1_22025678_ChIP-Seq_K562_Human1.00249316
112PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00138887
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.00083880
114LXR_22292898_ChIP-Seq_THP-1_Human0.99710296
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99276746
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.98142426
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97901904
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97547961
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97296168
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96790304
121SOX2_20726797_ChIP-Seq_SW620_Human0.95762532
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95286806
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95039375
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.94776534
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.93516014
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92870060
127RACK7_27058665_Chip-Seq_MCF-7_Human0.92855756
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92799080
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92198088
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90793596
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90325281
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90288516
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88302590
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86934457
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86658887
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85551605
137SA1_22415368_ChIP-Seq_MEFs_Mouse0.84767641
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83421964
139EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83235503
140EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83001696
141KLF5_25053715_ChIP-Seq_YYC3_Human0.82209325
142KDM2B_26808549_Chip-Seq_DND41_Human0.81643616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.00115385
2MP0005503_abnormal_tendon_morphology8.92386857
3MP0005275_abnormal_skin_tensile7.41238977
4MP0005257_abnormal_intraocular_pressure5.77818179
5MP0003279_aneurysm3.65602935
6MP0003705_abnormal_hypodermis_morpholog3.39482111
7MP0001958_emphysema3.15442450
8MP0002108_abnormal_muscle_morphology3.10272012
9MP0000751_myopathy3.08495485
10MP0006054_spinal_hemorrhage2.58060258
11MP0005670_abnormal_white_adipose2.54384723
12MP0004130_abnormal_muscle_cell2.42669790
13MP0005508_abnormal_skeleton_morphology2.42628992
14MP0004272_abnormal_basement_membrane2.19361365
15MP0009384_cardiac_valve_regurgitation2.03331565
16MP0001661_extended_life_span2.01783644
17MP0006138_congestive_heart_failure1.98668677
18MP0002933_joint_inflammation1.92456987
19MP0002060_abnormal_skin_morphology1.90678318
20MP0010368_abnormal_lymphatic_system1.77826874
21MP0002295_abnormal_pulmonary_circulatio1.64870437
22MP0003646_muscle_fatigue1.55488532
23MP0005666_abnormal_adipose_tissue1.52422626
24MP0005369_muscle_phenotype1.50657587
25MP0000747_muscle_weakness1.45056153
26MP0000749_muscle_degeneration1.42344801
27MP0002127_abnormal_cardiovascular_syste1.42297719
28MP0005390_skeleton_phenotype1.35771081
29MP0002332_abnormal_exercise_endurance1.34752438
30MP0004145_abnormal_muscle_electrophysio1.33514416
31MP0003137_abnormal_impulse_conducting1.29553832
32MP0005375_adipose_tissue_phenotype1.29231614
33MP0009250_abnormal_appendicular_skeleto1.26332797
34MP0000750_abnormal_muscle_regeneration1.25435353
35MP0004134_abnormal_chest_morphology1.23127286
36MP0001243_abnormal_dermal_layer1.16080848
37MP0005023_abnormal_wound_healing1.15519400
38MP0002106_abnormal_muscle_physiology1.12747031
39MP0005171_absent_coat_pigmentation1.12334047
40MP0004087_abnormal_muscle_fiber1.10854334
41MP0005083_abnormal_biliary_tract1.08714400
42MP0003283_abnormal_digestive_organ1.06982242
43MP0000759_abnormal_skeletal_muscle1.05465170
44MP0000163_abnormal_cartilage_morphology1.04996733
45MP0002837_dystrophic_cardiac_calcinosis0.99867048
46MP0003566_abnormal_cell_adhesion0.99815777
47MP0002971_abnormal_brown_adipose0.99240786
48MP0004085_abnormal_heartbeat0.99153799
49MP0002638_abnormal_pupillary_reflex0.98588795
50MP0000013_abnormal_adipose_tissue0.96590048
51MP0001542_abnormal_bone_strength0.94266841
52MP0002115_abnormal_skeleton_extremities0.93436644
53MP0000733_abnormal_muscle_development0.91769023
54MP0003724_increased_susceptibility_to0.89760809
55MP0001879_abnormal_lymphatic_vessel0.89423444
56MP0003385_abnormal_body_wall0.85260616
57MP0002932_abnormal_joint_morphology0.83218007
58MP0002896_abnormal_bone_mineralization0.83020672
59MP0004036_abnormal_muscle_relaxation0.81334907
60MP0005623_abnormal_meninges_morphology0.79146070
61MP0002282_abnormal_trachea_morphology0.78903309
62MP0000343_altered_response_to0.77556259
63MP0004084_abnormal_cardiac_muscle0.76635800
64MP0000767_abnormal_smooth_muscle0.73666526
65MP0005165_increased_susceptibility_to0.72051489
66MP0003567_abnormal_fetal_cardiomyocyte0.71285390
67MP0005167_abnormal_blood-brain_barrier0.70789483
68MP0000266_abnormal_heart_morphology0.70757404
69MP0001533_abnormal_skeleton_physiology0.70016028
70MP0003115_abnormal_respiratory_system0.69167049
71MP0005076_abnormal_cell_differentiation0.69114205
72MP0003075_altered_response_to0.68854985
73MP0009115_abnormal_fat_cell0.68090576
74MP0005330_cardiomyopathy0.67883096
75MP0002090_abnormal_vision0.66618840
76MP0001984_abnormal_olfaction0.66028004
77MP0002113_abnormal_skeleton_development0.65204372
78MP0004858_abnormal_nervous_system0.65035390
79MP0008775_abnormal_heart_ventricle0.63627900
80MP0005620_abnormal_muscle_contractility0.63472478
81MP0006276_abnormal_autonomic_nervous0.62530743
82MP0002133_abnormal_respiratory_system0.62299067
83MP0005388_respiratory_system_phenotype0.62299067
84MP0005197_abnormal_uvea_morphology0.62290565
85MP0001299_abnormal_eye_distance/0.61714496
86MP0002998_abnormal_bone_remodeling0.59213668
87MP0002128_abnormal_blood_circulation0.59069522
88MP0004270_analgesia0.58735734
89MP0000762_abnormal_tongue_morphology0.58123309
90MP0005595_abnormal_vascular_smooth0.57699204
91MP0000462_abnormal_digestive_system0.57657628
92MP0003091_abnormal_cell_migration0.57309677
93MP0010630_abnormal_cardiac_muscle0.56437734
94MP0002168_other_aberrant_phenotype0.54740455
95MP0003303_peritoneal_inflammation0.54611480
96MP0002269_muscular_atrophy0.53801701
97MP0003045_fibrosis0.53402881
98MP0002109_abnormal_limb_morphology0.52635491
99MP0008004_abnormal_stomach_pH0.52449019
100MP0006036_abnormal_mitochondrial_physio0.51346168
101MP0005266_abnormal_metabolism0.51109949
102MP0004185_abnormal_adipocyte_glucose0.50783768
103MP0002249_abnormal_larynx_morphology0.50647921
104MP0000428_abnormal_craniofacial_morphol0.50295633
105MP0003136_yellow_coat_color0.49885460
106MP0000049_abnormal_middle_ear0.49669749
107MP0001614_abnormal_blood_vessel0.47936221
108MP0005334_abnormal_fat_pad0.47734672
109MP0003828_pulmonary_edema0.47417738
110MP0002006_tumorigenesis0.46392396
111MP0004233_abnormal_muscle_weight0.46325533
112MP0004510_myositis0.46224359
113MP0010352_gastrointestinal_tract_polyps0.44606995
114MP0000534_abnormal_ureter_morphology0.44599641
115MP0001544_abnormal_cardiovascular_syste0.44554004
116MP0005385_cardiovascular_system_phenoty0.44554004
117MP0010771_integument_phenotype0.44349638
118MP0000003_abnormal_adipose_tissue0.44249532
119MP0002166_altered_tumor_susceptibility0.43874337
120MP0003959_abnormal_lean_body0.42954202
121MP0002972_abnormal_cardiac_muscle0.42441225
122MP0010386_abnormal_urinary_bladder0.41879274
123MP0000230_abnormal_systemic_arterial0.41280963
124MP0001177_atelectasis0.41193304
125MP0001175_abnormal_lung_morphology0.41185942
126MP0003948_abnormal_gas_homeostasis0.40467775
127MP0004215_abnormal_myocardial_fiber0.40307563
128MP0002233_abnormal_nose_morphology0.39926178
129MP0010030_abnormal_orbit_morphology0.39658634
130MP0009780_abnormal_chondrocyte_physiolo0.39658605
131MP0003950_abnormal_plasma_membrane0.39305414
132MP0003879_abnormal_hair_cell0.39052685
133MP0004484_altered_response_of0.38640583
134MP0000566_synostosis0.38516673
135MP0002114_abnormal_axial_skeleton0.38512946
136MP0003221_abnormal_cardiomyocyte_apopto0.38488457
137MP0009278_abnormal_bone_marrow0.37868894

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.54881882
2Premature rupture of membranes (HP:0001788)7.68622208
3Type 1 muscle fiber predominance (HP:0003803)6.58298134
4Ankle contracture (HP:0006466)5.94031880
5Soft skin (HP:0000977)5.61881624
6Broad metatarsal (HP:0001783)5.31808867
7Aortic dissection (HP:0002647)5.19445428
8Increased connective tissue (HP:0009025)5.10989075
9Follicular hyperkeratosis (HP:0007502)4.86073674
10Slender build (HP:0001533)4.79757292
11Calf muscle hypertrophy (HP:0008981)4.73483631
12Muscle hypertrophy of the lower extremities (HP:0008968)4.71969987
13Peritonitis (HP:0002586)4.65926333
14Flat cornea (HP:0007720)4.59324412
15Sudden death (HP:0001699)4.50753263
16Bladder diverticulum (HP:0000015)4.33451817
17Round ear (HP:0100830)4.17273370
18Atrophic scars (HP:0001075)4.17239486
19Spinal rigidity (HP:0003306)4.16978748
20Shallow orbits (HP:0000586)4.14249872
21Genu recurvatum (HP:0002816)4.03141201
22Dilatation of the ascending aorta (HP:0005111)3.95524798
23Neck muscle weakness (HP:0000467)3.87230984
24Increased variability in muscle fiber diameter (HP:0003557)3.85900842
25Bundle branch block (HP:0011710)3.83166669
26Fragile skin (HP:0001030)3.82897859
27Muscle fiber splitting (HP:0003555)3.75695808
28Mitral valve prolapse (HP:0001634)3.73274614
29Wrist flexion contracture (HP:0001239)3.71275689
30Mildly elevated creatine phosphokinase (HP:0008180)3.71145327
31Abnormality of dentin (HP:0010299)3.68343133
32Difficulty running (HP:0009046)3.67332461
33Biconcave vertebral bodies (HP:0004586)3.62981861
34Neonatal short-limb short stature (HP:0008921)3.62541612
35Abnormality of skeletal muscle fiber size (HP:0012084)3.59453989
36Vertebral compression fractures (HP:0002953)3.57165805
37Absent phalangeal crease (HP:0006109)3.55576842
38Abnormality of the left ventricular outflow tract (HP:0011103)3.48203225
39Subaortic stenosis (HP:0001682)3.48203225
40Cerebral aneurysm (HP:0004944)3.46848811
41Rimmed vacuoles (HP:0003805)3.42566519
42Asymmetric septal hypertrophy (HP:0001670)3.41965976
43Centrally nucleated skeletal muscle fibers (HP:0003687)3.39530881
44Aortic aneurysm (HP:0004942)3.38050229
45Myopathic facies (HP:0002058)3.33459378
46Hyperextensible skin (HP:0000974)3.28833852
47Lipoatrophy (HP:0100578)3.28723721
48Distal lower limb muscle weakness (HP:0009053)3.23976606
49Ventricular tachycardia (HP:0004756)3.23252476
50Striae distensae (HP:0001065)3.15673960
51Wormian bones (HP:0002645)3.07991240
52Myotonia (HP:0002486)2.99242549
53Blue sclerae (HP:0000592)2.97997288
54Abnormal finger flexion creases (HP:0006143)2.95539802
55Dilated cardiomyopathy (HP:0001644)2.94985243
56Broad ribs (HP:0000885)2.93178431
57Abnormal delivery (HP:0001787)2.91530391
58Myoglobinuria (HP:0002913)2.86682482
59Atrial fibrillation (HP:0005110)2.83605394
60EMG: neuropathic changes (HP:0003445)2.83358648
61Joint laxity (HP:0001388)2.83065161
62Muscle fiber inclusion bodies (HP:0100299)2.75614744
63Ulnar deviation of the wrist (HP:0003049)2.75440103
64Scapular winging (HP:0003691)2.75405728
65Malignant hyperthermia (HP:0002047)2.73417192
66Proximal amyotrophy (HP:0007126)2.72710296
67Deformed tarsal bones (HP:0008119)2.71922878
68Calcaneovalgus deformity (HP:0001848)2.67518084
69Rhabdomyolysis (HP:0003201)2.67329106
70Ectopia lentis (HP:0001083)2.64517652
71Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.64073194
72Metatarsus adductus (HP:0001840)2.63966447
73Frequent falls (HP:0002359)2.59982648
74Cervical subluxation (HP:0003308)2.59685305
75Osteoarthritis (HP:0002758)2.58461198
76Infantile muscular hypotonia (HP:0008947)2.57161357
77Overgrowth (HP:0001548)2.55407420
78Mild short stature (HP:0003502)2.54437672
79Generalized amyotrophy (HP:0003700)2.51942796
80Primary atrial arrhythmia (HP:0001692)2.51298637
81Areflexia of lower limbs (HP:0002522)2.48737059
82Exercise-induced muscle cramps (HP:0003710)2.44230945
83Breech presentation (HP:0001623)2.42679342
84Fetal akinesia sequence (HP:0001989)2.42416586
85Bulbar palsy (HP:0001283)2.42130129
86Bowel diverticulosis (HP:0005222)2.41487322
87Heart block (HP:0012722)2.40559723
88Elbow flexion contracture (HP:0002987)2.39252189
89Thin bony cortex (HP:0002753)2.37954544
90Vascular tortuosity (HP:0004948)2.37674183
91Supraventricular tachycardia (HP:0004755)2.36480774
92Nemaline bodies (HP:0003798)2.35364864
93Abnormality of the acetabulum (HP:0003170)2.35243812
94Abnormality of the calcaneus (HP:0008364)2.34937144
95Spondylolisthesis (HP:0003302)2.34246881
96Rectal prolapse (HP:0002035)2.33955188
97Abnormality of the foot musculature (HP:0001436)2.33327788
98Muscular dystrophy (HP:0003560)2.33316601
99Supraventricular arrhythmia (HP:0005115)2.33091306
100Mitral stenosis (HP:0001718)2.31507414
101Exercise-induced myalgia (HP:0003738)2.31318649
102Arterial tortuosity (HP:0005116)2.30471804
103Venous insufficiency (HP:0005293)2.29446604
104Abnormal atrioventricular conduction (HP:0005150)2.28914211
105Limb-girdle muscle weakness (HP:0003325)2.26007089
106Pulmonary artery stenosis (HP:0004415)2.25858597
107Right ventricular cardiomyopathy (HP:0011663)2.23686446
108Oligomenorrhea (HP:0000876)2.22451201
109Syncope (HP:0001279)2.21349172
110Neoplasm of the heart (HP:0100544)2.20346085
111Generalized muscle weakness (HP:0003324)2.19379064
112Joint stiffness (HP:0001387)2.18461762
113Gowers sign (HP:0003391)2.17222068
114Muscle stiffness (HP:0003552)2.16430066
115Foot dorsiflexor weakness (HP:0009027)2.15957292
116Venous abnormality (HP:0002624)2.15509814
117Hypoventilation (HP:0002791)2.14010666
118Distal lower limb amyotrophy (HP:0008944)2.11425350
119Abnormality of the shoulder girdle musculature (HP:0001435)2.08602137
120Ventricular arrhythmia (HP:0004308)2.05955002
121Aneurysm (HP:0002617)2.05847806
122Hypoplasia of the iris (HP:0007676)2.05814507
123Complement deficiency (HP:0004431)2.04897342
124Wide anterior fontanel (HP:0000260)2.03958954
125Aortic regurgitation (HP:0001659)2.03475718
126Distal arthrogryposis (HP:0005684)2.03446554
127Limb-girdle muscle atrophy (HP:0003797)2.02058898
128Narrow nasal bridge (HP:0000446)2.00863545
129Waddling gait (HP:0002515)2.00275156
130Camptodactyly of toe (HP:0001836)2.00150049
131Steppage gait (HP:0003376)1.99823823
132Abnormality of the peritoneum (HP:0002585)1.99232564
133Nonimmune hydrops fetalis (HP:0001790)1.96199357
134Deviation of the hallux (HP:0010051)1.92492530
135Disproportionate tall stature (HP:0001519)1.91739872
136Abnormality of the ischium (HP:0003174)1.91501461
137Mesomelia (HP:0003027)1.91345957
138Limited hip movement (HP:0008800)1.91000576
139Respiratory insufficiency due to muscle weakness (HP:0002747)1.89893644
140Beaking of vertebral bodies (HP:0004568)1.88574671
141Hallux valgus (HP:0001822)1.84199843
142Lumbar hyperlordosis (HP:0002938)1.83817860
143Hyperkalemia (HP:0002153)1.83355804
144Bell-shaped thorax (HP:0001591)1.82916168
145Recurrent gram-negative bacterial infections (HP:0005420)1.82171922
146Popliteal pterygium (HP:0009756)1.81337292
147Hyporeflexia of lower limbs (HP:0002600)1.80663621
148Ovoid vertebral bodies (HP:0003300)1.80029245
149Hip contracture (HP:0003273)1.79386763
150Amyloidosis (HP:0011034)1.78883723
151EMG: myopathic abnormalities (HP:0003458)1.78461766
152Mitral regurgitation (HP:0001653)1.78227095
153Hypoplastic ischia (HP:0003175)1.77526449
154Tarsal synostosis (HP:0008368)1.73932355
155Aplasia of the musculature (HP:0100854)1.73784526
156Prolonged QT interval (HP:0001657)1.73553003
157Abnormality of the calf musculature (HP:0001430)1.72463057
158Achilles tendon contracture (HP:0001771)1.71840698
159Difficulty climbing stairs (HP:0003551)1.70782393
160Thin skin (HP:0000963)1.70285383
161Lower limb amyotrophy (HP:0007210)1.69503483
162Small epiphyses (HP:0010585)1.67610857
163Atrioventricular block (HP:0001678)1.65390520
164Trismus (HP:0000211)1.63795158
165Weak cry (HP:0001612)1.63712674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.65636301
2DDR24.32324070
3LATS23.81681705
4ERN13.73854051
5TTN3.64781801
6TRIB33.25302242
7PDGFRA3.13507345
8RIPK13.12512631
9EPHA32.69078822
10PKN22.43144924
11SIK12.40798641
12PINK12.36230575
13EPHB12.28786894
14PHKG12.28691810
15PHKG22.28691810
16EEF2K2.13064907
17LATS12.11755677
18DMPK1.73394288
19TGFBR21.68656491
20LMTK21.52487564
21MAPKAPK31.48296255
22PIK3CG1.40714427
23MARK11.35800495
24NLK1.33740985
25PTK2B1.32350702
26EPHB21.30063207
27MAP3K31.29552127
28PRKD31.28804885
29MAP3K71.28065968
30MAP3K131.21298377
31MST1R1.16571309
32PIK3CA1.15818752
33STK38L1.15792924
34FER1.14227648
35MET1.14204238
36CSK1.13684806
37BMX1.11606948
38PRKCH1.11176948
39PAK21.10955524
40SGK21.09274670
41PDGFRB1.09243536
42FGFR41.04613127
43MAPK71.01875227
44CAMK11.01324932
45MAP2K30.98874052
46PRKAA10.97695369
47MYLK0.97609297
48SGK2230.95769879
49SGK4940.95769879
50PDK20.91860344
51PDK30.91673516
52PDK40.91673516
53STK240.88797838
54NEK90.88778204
55TSSK60.88653718
56PTK60.87911034
57NME10.86035852
58MARK20.85848728
59PTK20.82430170
60SGK30.82164326
61ERBB40.81321910
62RET0.81100375
63FGFR10.76855901
64TAOK10.76616728
65PRKG10.75643777
66PRKD20.74517827
67KIT0.74090943
68LRRK20.73932293
69ROCK10.72461955
70PRKD10.72378732
71TNIK0.72281892
72MOS0.72109901
73BLK0.71811901
74STK30.70394696
75JAK20.70359151
76PAK30.66228997
77JAK10.65897298
78FLT30.64240077
79MAP3K60.63952482
80PKN10.63862822
81LIMK10.62585988
82MAPK120.62159702
83GSK3A0.61934003
84NTRK10.61585932
85NEK10.60929957
86ARAF0.60038250
87MAP2K10.59400727
88FGFR30.59031947
89MAPKAPK50.58372709
90AKT20.56901298
91ILK0.56637027
92CAMK2G0.56316677
93PAK40.55336419
94CAMK2A0.54525669
95KSR20.53258927
96CAMK2D0.50149645
97MAPK150.47266149
98IRAK10.47068293
99PRKAA20.46882745
100DYRK1B0.46607075
101PRKACA0.45117829
102MTOR0.44522182
103RPS6KA30.43812159
104CDC42BPA0.43665009
105MAP3K90.43446958
106ERBB20.43166682
107PRKACB0.42146845
108TAOK20.41632056
109ABL20.41544100
110PIM20.41460179
111CCNB10.41326972
112STK40.40808838
113TRPM70.39980317
114WNK10.39429121
115ROCK20.38383054
116CAMK2B0.37070656
117MAP3K100.37042482
118ADRBK10.36429792
119AKT30.35975929
120MAPK100.34899367
121INSR0.34572933
122CDK50.34431152
123MAP2K40.34193836
124PRKACG0.33213678
125SRC0.33082819
126MARK30.33030030
127RPS6KC10.32402021
128RPS6KL10.32402021
129SGK10.32211757
130DYRK1A0.32171532
131MUSK0.31951861
132TESK10.31754918
133DAPK30.31239224
134DAPK20.30915326
135ICK0.29721870
136PRKCE0.29674834
137STK110.29582622
138JAK30.29565875
139PAK60.29140441
140CAMK40.26640223
141ERBB30.25886662
142BCKDK0.25858370
143RPS6KA60.25410387
144MAP3K20.25374212
145CDK90.25004619
146MAP3K10.23776961
147MAPK10.23570000
148UHMK10.23263214
149TIE10.23122067
150MAPK40.22112841

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045125.43092312
2Protein digestion and absorption_Homo sapiens_hsa049744.03427628
3* Focal adhesion_Homo sapiens_hsa045103.07771550
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.03265022
5Dilated cardiomyopathy_Homo sapiens_hsa054142.92561013
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.59167758
7Prion diseases_Homo sapiens_hsa050202.40114429
8Amoebiasis_Homo sapiens_hsa051462.26521068
9* Malaria_Homo sapiens_hsa051442.20031655
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.14927148
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.96614838
12Complement and coagulation cascades_Homo sapiens_hsa046101.58424367
13Proteoglycans in cancer_Homo sapiens_hsa052051.56613095
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54988741
15TGF-beta signaling pathway_Homo sapiens_hsa043501.48483086
16* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.47842546
17PPAR signaling pathway_Homo sapiens_hsa033201.47681469
18Propanoate metabolism_Homo sapiens_hsa006401.41761425
19Insulin resistance_Homo sapiens_hsa049311.41234839
20AMPK signaling pathway_Homo sapiens_hsa041521.34803136
21Bladder cancer_Homo sapiens_hsa052191.18311862
22ABC transporters_Homo sapiens_hsa020101.17951407
23Phenylalanine metabolism_Homo sapiens_hsa003601.15270242
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.13260918
25Starch and sucrose metabolism_Homo sapiens_hsa005001.13034381
26Adherens junction_Homo sapiens_hsa045201.11691788
27Cardiac muscle contraction_Homo sapiens_hsa042601.08561153
28Nitrogen metabolism_Homo sapiens_hsa009101.06702973
29Small cell lung cancer_Homo sapiens_hsa052221.05952165
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.05436278
31Viral myocarditis_Homo sapiens_hsa054161.03848211
32Pyruvate metabolism_Homo sapiens_hsa006201.03763745
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01087636
34Toxoplasmosis_Homo sapiens_hsa051451.00758967
35Basal cell carcinoma_Homo sapiens_hsa052171.00635044
36Estrogen signaling pathway_Homo sapiens_hsa049151.00434860
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00230908
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98647305
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96703266
40HIF-1 signaling pathway_Homo sapiens_hsa040660.96581444
41Hippo signaling pathway_Homo sapiens_hsa043900.95233493
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93561588
43Hedgehog signaling pathway_Homo sapiens_hsa043400.93542613
44MicroRNAs in cancer_Homo sapiens_hsa052060.92950938
45cAMP signaling pathway_Homo sapiens_hsa040240.92014020
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86895421
47GnRH signaling pathway_Homo sapiens_hsa049120.86769349
48TNF signaling pathway_Homo sapiens_hsa046680.85772848
49Platelet activation_Homo sapiens_hsa046110.85261240
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84905010
51Glucagon signaling pathway_Homo sapiens_hsa049220.83194317
52Salivary secretion_Homo sapiens_hsa049700.80681880
53Oxytocin signaling pathway_Homo sapiens_hsa049210.80216345
54Arginine biosynthesis_Homo sapiens_hsa002200.80084937
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76871970
56Wnt signaling pathway_Homo sapiens_hsa043100.75326979
57Circadian rhythm_Homo sapiens_hsa047100.75173755
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73676736
59Melanogenesis_Homo sapiens_hsa049160.73042102
60Insulin signaling pathway_Homo sapiens_hsa049100.71426329
61Pancreatic secretion_Homo sapiens_hsa049720.70998852
62Tyrosine metabolism_Homo sapiens_hsa003500.69193397
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68837009
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68291345
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.68227139
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.68059159
67Carbon metabolism_Homo sapiens_hsa012000.67657829
68Osteoclast differentiation_Homo sapiens_hsa043800.65199001
69Fatty acid biosynthesis_Homo sapiens_hsa000610.64342857
70Long-term potentiation_Homo sapiens_hsa047200.64101536
71Histidine metabolism_Homo sapiens_hsa003400.63755754
72Gap junction_Homo sapiens_hsa045400.63562408
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63240963
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62846305
75Type II diabetes mellitus_Homo sapiens_hsa049300.61916313
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61485785
77Pathways in cancer_Homo sapiens_hsa052000.61447575
78MAPK signaling pathway_Homo sapiens_hsa040100.60641761
79GABAergic synapse_Homo sapiens_hsa047270.60102153
80Cholinergic synapse_Homo sapiens_hsa047250.59216843
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57638276
82Arginine and proline metabolism_Homo sapiens_hsa003300.57622312
83Axon guidance_Homo sapiens_hsa043600.57590239
84Calcium signaling pathway_Homo sapiens_hsa040200.57565723
85Thyroid hormone synthesis_Homo sapiens_hsa049180.56012475
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55953073
87Amphetamine addiction_Homo sapiens_hsa050310.55789336
88Notch signaling pathway_Homo sapiens_hsa043300.55448951
89Tight junction_Homo sapiens_hsa045300.55441960
90Chronic myeloid leukemia_Homo sapiens_hsa052200.55406003
91Gastric acid secretion_Homo sapiens_hsa049710.55186400
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55017363
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54662378
94Olfactory transduction_Homo sapiens_hsa047400.54529971
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54495061
96Cocaine addiction_Homo sapiens_hsa050300.54255817
97Melanoma_Homo sapiens_hsa052180.54022064
98Glioma_Homo sapiens_hsa052140.53963124
99beta-Alanine metabolism_Homo sapiens_hsa004100.53665583
100mTOR signaling pathway_Homo sapiens_hsa041500.53483661
101Pertussis_Homo sapiens_hsa051330.53211458
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52897924
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51910558
104Morphine addiction_Homo sapiens_hsa050320.50881289
105Oocyte meiosis_Homo sapiens_hsa041140.47812396
106Fatty acid degradation_Homo sapiens_hsa000710.47125747
107Endometrial cancer_Homo sapiens_hsa052130.46893659
108Dorso-ventral axis formation_Homo sapiens_hsa043200.46757616
109Rap1 signaling pathway_Homo sapiens_hsa040150.46517814
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46463635
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45715503
112Galactose metabolism_Homo sapiens_hsa000520.45033627
113HTLV-I infection_Homo sapiens_hsa051660.44374236
114Renin secretion_Homo sapiens_hsa049240.43427272
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43280688
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42788981
117FoxO signaling pathway_Homo sapiens_hsa040680.42360191
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39301565
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39104611
120African trypanosomiasis_Homo sapiens_hsa051430.38644404
121Renin-angiotensin system_Homo sapiens_hsa046140.38559033
122Lysine degradation_Homo sapiens_hsa003100.38200137
123Prostate cancer_Homo sapiens_hsa052150.36439884
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.36404053
125Bile secretion_Homo sapiens_hsa049760.36235466
126Insulin secretion_Homo sapiens_hsa049110.36008328
127Renal cell carcinoma_Homo sapiens_hsa052110.35727779
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35438997
129Fatty acid metabolism_Homo sapiens_hsa012120.35255094
130Ovarian steroidogenesis_Homo sapiens_hsa049130.34342498
131VEGF signaling pathway_Homo sapiens_hsa043700.34011781
132Circadian entrainment_Homo sapiens_hsa047130.32896105
133* Phagosome_Homo sapiens_hsa041450.32170065

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