THEG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is specifically expressed in the nucleus of haploid male germ cells. The orthologous gene in mice encodes a protein that may play a role in protein assembly through interactions with T-complex protein 1 subunit epsilon. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.91805516
2axonemal dynein complex assembly (GO:0070286)9.88594859
3epithelial cilium movement (GO:0003351)9.88067469
4plasma membrane fusion (GO:0045026)9.85741071
5motile cilium assembly (GO:0044458)9.57033039
6reproduction (GO:0000003)9.14666486
7negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.02441526
8regulation of cilium movement (GO:0003352)8.97219923
9cilium or flagellum-dependent cell motility (GO:0001539)8.79161962
10cilium movement (GO:0003341)7.95400036
11regulation of retinoic acid receptor signaling pathway (GO:0048385)7.60758013
12negative regulation of inclusion body assembly (GO:0090084)7.52491631
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39055410
14single fertilization (GO:0007338)7.27418843
15sperm capacitation (GO:0048240)7.25250181
16synaptonemal complex organization (GO:0070193)7.13936423
17piRNA metabolic process (GO:0034587)7.02960861
18microtubule depolymerization (GO:0007019)6.94422248
19synaptonemal complex assembly (GO:0007130)6.93417834
20male meiosis (GO:0007140)6.89035168
21* spermatogenesis (GO:0007283)6.82939825
22* male gamete generation (GO:0048232)6.80444604
23organic cation transport (GO:0015695)6.65732191
24* gamete generation (GO:0007276)6.24997255
25regulation of inclusion body assembly (GO:0090083)6.19849707
26fertilization (GO:0009566)6.19685064
27rRNA methylation (GO:0031167)5.97292286
28calcium ion-dependent exocytosis (GO:0017156)5.78789791
29germ cell development (GO:0007281)5.47245101
30rRNA modification (GO:0000154)5.39363917
31chromosome condensation (GO:0030261)5.39293471
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.38027267
33regulation of microtubule-based movement (GO:0060632)5.23322286
34phosphatidylethanolamine biosynthetic process (GO:0006646)5.17775607
35ventricular system development (GO:0021591)5.10745811
36DNA packaging (GO:0006323)5.10737303
37glycerol ether metabolic process (GO:0006662)5.08561161
38male meiosis I (GO:0007141)5.02168639
39response to pheromone (GO:0019236)5.01649571
40cell recognition (GO:0008037)4.98389347
41spermatid nucleus differentiation (GO:0007289)4.96635960
42* multicellular organismal reproductive process (GO:0048609)4.91685222
43cellular response to pH (GO:0071467)4.82148772
44microtubule severing (GO:0051013)4.80044795
45phosphatidylethanolamine metabolic process (GO:0046337)4.70297778
46chromosome organization involved in meiosis (GO:0070192)4.70210973
47ether metabolic process (GO:0018904)4.70128223
48protein targeting to Golgi (GO:0000042)4.60370992
49seminiferous tubule development (GO:0072520)4.60271271
50establishment of protein localization to Golgi (GO:0072600)4.53671513
51DNA methylation involved in gamete generation (GO:0043046)4.51870569
52left/right pattern formation (GO:0060972)4.48318528
53retrograde transport, vesicle recycling within Golgi (GO:0000301)4.44810668
54meiotic nuclear division (GO:0007126)4.17249102
55response to acidic pH (GO:0010447)4.16817420
56cellular ketone body metabolic process (GO:0046950)4.12794768
57regulation of centriole replication (GO:0046599)4.12764400
58single strand break repair (GO:0000012)4.12551514
59regulation of female gonad development (GO:2000194)4.06925219
60sexual reproduction (GO:0019953)4.05261507
61meiosis I (GO:0007127)4.02758212
62regulation of Rab GTPase activity (GO:0032313)3.92375821
63positive regulation of Rab GTPase activity (GO:0032851)3.92375821
64* multicellular organismal development (GO:0007275)3.92096603
65centriole replication (GO:0007099)3.88120551
66regulation of transcription involved in cell fate commitment (GO:0060850)3.72708788
67musculoskeletal movement (GO:0050881)3.65012794
68multicellular organismal movement (GO:0050879)3.65012794
69centriole assembly (GO:0098534)3.61660706
70protein polyglutamylation (GO:0018095)3.60297131
71microtubule polymerization or depolymerization (GO:0031109)3.59643850
72ketone body metabolic process (GO:1902224)3.57333465
73protein K11-linked deubiquitination (GO:0035871)3.52039320
74genitalia morphogenesis (GO:0035112)3.50871078
75regulation of interleukin-13 production (GO:0032656)3.50245107
76regulation of spindle checkpoint (GO:0090231)3.49909760
77protein refolding (GO:0042026)3.45305156
78sequestering of actin monomers (GO:0042989)3.40877865
79histone H3-K9 demethylation (GO:0033169)3.40596513
80meiotic cell cycle (GO:0051321)3.38165471
81nucleosome disassembly (GO:0006337)3.36401402
82protein-DNA complex disassembly (GO:0032986)3.36401402
83regulation of acrosome reaction (GO:0060046)3.30409260
84polyol catabolic process (GO:0046174)3.29374347
85cerebral cortex neuron differentiation (GO:0021895)3.29108228
86protein localization to Golgi apparatus (GO:0034067)3.27737777
87peptidyl-threonine dephosphorylation (GO:0035970)3.26442107
88mitotic sister chromatid cohesion (GO:0007064)3.25275039
89monoubiquitinated protein deubiquitination (GO:0035520)3.25098248
90glycolytic process (GO:0006096)3.25093586
91nucleoside diphosphate phosphorylation (GO:0006165)3.22664173
92membrane protein intracellular domain proteolysis (GO:0031293)3.22087639
93protein localization to cilium (GO:0061512)3.21961218
94mesonephros development (GO:0001823)3.20865620
95alditol metabolic process (GO:0019400)3.16998798
96nucleus organization (GO:0006997)3.14969008
97outflow tract septum morphogenesis (GO:0003148)3.13140440
98oocyte development (GO:0048599)3.10113868
99carnitine transport (GO:0015879)3.07961285
100amino-acid betaine transport (GO:0015838)3.07961285
101face development (GO:0060324)3.05364319
102polyamine biosynthetic process (GO:0006596)3.01745731
103mitotic G1 DNA damage checkpoint (GO:0031571)3.00706919
104protein depolymerization (GO:0051261)2.98557344
105GTP biosynthetic process (GO:0006183)2.97318724
106RNA localization (GO:0006403)2.93329885
107interferon-gamma secretion (GO:0072643)2.91535278
108carnitine transmembrane transport (GO:1902603)2.90270801
109RNA destabilization (GO:0050779)2.86344425
110coenzyme catabolic process (GO:0009109)2.85020293
111cilium organization (GO:0044782)2.82309448
112meiotic cell cycle process (GO:1903046)2.81771887
113negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.76524103
114cell-cell junction maintenance (GO:0045217)2.76356234
115microtubule-based movement (GO:0007018)2.73273085
116cilium assembly (GO:0042384)2.71985589
117negative regulation of histone methylation (GO:0031061)2.71290953
118cilium morphogenesis (GO:0060271)2.71009203
119positive regulation of macrophage activation (GO:0043032)2.70968791
120cellular component assembly involved in morphogenesis (GO:0010927)2.67961407
121synapsis (GO:0007129)2.67055831
122intraciliary transport (GO:0042073)2.66614688
123glycerol metabolic process (GO:0006071)2.66116024
124axoneme assembly (GO:0035082)2.64334987
125cell proliferation involved in metanephros development (GO:0072203)2.64275847
126mitotic G1/S transition checkpoint (GO:0044819)2.63808559
127G1 DNA damage checkpoint (GO:0044783)2.63369974
128UTP biosynthetic process (GO:0006228)2.63113799
129intracellular estrogen receptor signaling pathway (GO:0030520)2.61797634
130mitochondrion degradation (GO:0000422)2.60918416
131regulation of histone H3-K27 methylation (GO:0061085)2.60212474
132chromatin silencing (GO:0006342)2.59611490
133regulation of cilium assembly (GO:1902017)2.59352990
134regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.59083825
135positive regulation of action potential (GO:0045760)2.58888960
136negative regulation of organelle assembly (GO:1902116)2.58837721
137negative regulation of gene expression, epigenetic (GO:0045814)2.58520364
138lactate metabolic process (GO:0006089)2.48916677
139peptidyl-glutamic acid modification (GO:0018200)2.48648709
140negative regulation of skeletal muscle tissue development (GO:0048642)2.48569969
141sperm motility (GO:0030317)14.3166966
142fusion of sperm to egg plasma membrane (GO:0007342)12.9378685
143acrosome reaction (GO:0007340)12.5588292
144cell wall macromolecule metabolic process (GO:0044036)12.4449432
145cell wall macromolecule catabolic process (GO:0016998)12.4449432
146sperm-egg recognition (GO:0035036)11.4501565
147acrosome assembly (GO:0001675)11.3674950
148multicellular organism reproduction (GO:0032504)10.6021076
149binding of sperm to zona pellucida (GO:0007339)10.4973050
150cell-cell recognition (GO:0009988)10.2367504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.00323653
2EZH2_22144423_ChIP-Seq_EOC_Human4.65794191
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94323359
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30488563
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.13918604
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.79146885
7VDR_22108803_ChIP-Seq_LS180_Human2.75273612
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.70681953
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.69827760
10DROSHA_22980978_ChIP-Seq_HELA_Human2.51479204
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34972202
12SMC4_20622854_ChIP-Seq_HELA_Human2.26280046
13CTCF_27219007_Chip-Seq_Bcells_Human2.23007624
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20711838
15LXR_22292898_ChIP-Seq_THP-1_Human2.19428640
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.18071158
17P68_20966046_ChIP-Seq_HELA_Human2.16689602
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15856366
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13976921
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.13684879
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07820728
22ZNF274_21170338_ChIP-Seq_K562_Hela2.05506056
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.95149750
24TP63_22573176_ChIP-Seq_HFKS_Human1.94072232
25* ERA_21632823_ChIP-Seq_H3396_Human1.93978920
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.91664978
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.89072654
28E2F1_20622854_ChIP-Seq_HELA_Human1.85205633
29* BCOR_27268052_Chip-Seq_Bcells_Human1.85158554
30* RAC3_21632823_ChIP-Seq_H3396_Human1.84116938
31TDRD3_21172665_ChIP-Seq_MCF-7_Human1.80534043
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.80501845
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79765918
34PHF8_20622854_ChIP-Seq_HELA_Human1.78647645
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.77275115
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76510419
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.75068742
38BCL6_27268052_Chip-Seq_Bcells_Human1.73191063
39STAT1_17558387_ChIP-Seq_HELA_Human1.72337062
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71551046
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71050351
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69918933
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.69139082
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69056505
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.66781919
46MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.65302605
47SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.64897917
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.62648686
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59731701
50* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58768024
51SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58121911
52NANOG_20526341_ChIP-Seq_ESCs_Human1.52222896
53AHR_22903824_ChIP-Seq_MCF-7_Human1.51899438
54P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.50824949
55* OCT4_20526341_ChIP-Seq_ESCs_Human1.49192777
56GATA3_21867929_ChIP-Seq_CD8_Mouse1.49135766
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.48701171
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45459020
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.44736064
60* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44460379
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.43665036
62FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42803358
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42076812
64OCT4_19829295_ChIP-Seq_ESCs_Human1.41397079
65KDM2B_26808549_Chip-Seq_REH_Human1.41333819
66REST_21632747_ChIP-Seq_MESCs_Mouse1.40436919
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38621186
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37727263
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36935309
70CBP_20019798_ChIP-Seq_JUKART_Human1.36141621
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36141621
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.33520383
73P300_27268052_Chip-Seq_Bcells_Human1.33202063
74* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31302847
75KLF5_25053715_ChIP-Seq_YYC3_Human1.31173744
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.30757813
77P53_21459846_ChIP-Seq_SAOS-2_Human1.29634629
78SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27741626
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27242318
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.27058184
81GF1_26923725_Chip-Seq_HPCs_Mouse1.26093364
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25842785
83TAF2_19829295_ChIP-Seq_ESCs_Human1.24988866
84SA1_27219007_Chip-Seq_Bcells_Human1.24966642
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.24093762
86* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23912576
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23674349
88* RACK7_27058665_Chip-Seq_MCF-7_Human1.23497466
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23161080
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22993546
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22213055
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22111041
93TAF15_26573619_Chip-Seq_HEK293_Human1.19832960
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19748807
95CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19624042
96MYC_19829295_ChIP-Seq_ESCs_Human1.19098675
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18141462
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15801644
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15522936
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15454583
101* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14693413
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14431461
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14431461
104CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12846511
105PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12576613
106TET1_21490601_ChIP-Seq_MESCs_Mouse1.12448011
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12061346
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11286410
109CTCF_21964334_Chip-Seq_Bcells_Human1.11236517
110SPI1_26923725_Chip-Seq_HPCs_Mouse1.10976686
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.10902262
112SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10815146
113SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10551775
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.09819927
115KLF4_19829295_ChIP-Seq_ESCs_Human1.09510280
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09018805
117ER_23166858_ChIP-Seq_MCF-7_Human1.08462962
118ERG_20517297_ChIP-Seq_VCAP_Human1.08451006
119CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08443322
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08241893
121PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07694619
122MYC_27129775_Chip-Seq_CORNEA_Mouse1.07358502
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.06636227
124RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05976683
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05753473
126RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05672908
127ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05650116
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04826634
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.04817862
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03944408
131HOXB7_26014856_ChIP-Seq_BT474_Human1.03462363
132RBPJ_21746931_ChIP-Seq_IB4_Human1.03247421
133GATA3_21878914_ChIP-Seq_MCF-7_Human1.01739647
134YY1_22570637_ChIP-Seq_MALME-3M_Human1.00949392
135CREB1_26743006_Chip-Seq_LNCaP_Human1.00889342
136KDM2B_26808549_Chip-Seq_K562_Human1.00670302
137* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00347790
138P53_22387025_ChIP-Seq_ESCs_Mouse0.99791871
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99328701
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99318269
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99178590
142* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98903828
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.98505422
144JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98428124
145RARA_24833708_ChIP-Seq_LIVER_Mouse0.97977474
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97870179
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97463176
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.96268096
149GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95936003
150RNF2_27304074_Chip-Seq_NSC_Mouse0.94880949
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94825896
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94548454
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.94367516
154NFYB_21822215_ChIP-Seq_K562_Human0.94271430
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94064670
156EZH2_27304074_Chip-Seq_ESCs_Mouse0.94039233
157CTCF_20526341_ChIP-Seq_ESCs_Human0.93037335
158PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92511423
159OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92121269
160CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91937486
161SOX9_26525672_Chip-Seq_HEART_Mouse0.91874621
162SOX2_21211035_ChIP-Seq_LN229_Human0.91810344
163E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91291652
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90909722
165LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90600262
166TBL1_22424771_ChIP-Seq_293T_Human0.90572597
167SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90423896
168NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90280588
169CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90149354
170MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90082367
171DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89508208
172EZH2_27294783_Chip-Seq_NPCs_Mouse0.89413244
173* TET1_21451524_ChIP-Seq_MESCs_Mouse0.89372765
174P300_18555785_Chip-Seq_ESCs_Mouse0.89162705
175SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88800386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.97190325
2* MP0001929_abnormal_gametogenesis5.41919770
3MP0008877_abnormal_DNA_methylation4.08584077
4* MP0002161_abnormal_fertility/fecundity3.26033890
5* MP0002210_abnormal_sex_determination3.17787765
6MP0003718_maternal_effect3.17464652
7MP0001348_abnormal_lacrimal_gland3.08769896
8MP0005670_abnormal_white_adipose2.97958212
9* MP0001145_abnormal_male_reproductive2.70708020
10MP0002249_abnormal_larynx_morphology2.69027842
11MP0000678_abnormal_parathyroid_gland2.57582427
12MP0002822_catalepsy2.53219373
13MP0002796_impaired_skin_barrier2.45168555
14* MP0000653_abnormal_sex_gland2.34016794
15MP0000579_abnormal_nail_morphology2.20088015
16MP0002653_abnormal_ependyma_morphology2.03490806
17MP0005410_abnormal_fertilization16.6183479
18MP0003646_muscle_fatigue1.69534318
19MP0002160_abnormal_reproductive_system1.58831378
20MP0002098_abnormal_vibrissa_morphology1.48792011
21MP0009053_abnormal_anal_canal1.45771837
22MP0005623_abnormal_meninges_morphology1.35155080
23MP0004233_abnormal_muscle_weight1.33627703
24MP0005395_other_phenotype1.25224097
25MP0004381_abnormal_hair_follicle1.25135690
26MP0004264_abnormal_extraembryonic_tissu1.22493023
27MP0005394_taste/olfaction_phenotype1.21766412
28MP0005499_abnormal_olfactory_system1.21766412
29MP0001486_abnormal_startle_reflex1.21379711
30MP0002735_abnormal_chemical_nociception1.19662621
31MP0001485_abnormal_pinna_reflex1.16161097
32MP0002234_abnormal_pharynx_morphology1.10863465
33MP0002282_abnormal_trachea_morphology1.10550088
34MP0000470_abnormal_stomach_morphology1.10108151
35MP0001765_abnormal_ion_homeostasis1.10023193
36MP0000467_abnormal_esophagus_morphology1.09341496
37MP0000026_abnormal_inner_ear1.07955445
38MP0005501_abnormal_skin_physiology1.07138520
39MP0002127_abnormal_cardiovascular_syste1.07037007
40MP0001984_abnormal_olfaction1.06559748
41MP0000566_synostosis1.05086863
42MP0004859_abnormal_synaptic_plasticity1.04197845
43MP0008789_abnormal_olfactory_epithelium1.00438575
44MP0001905_abnormal_dopamine_level0.98110880
45MP0008058_abnormal_DNA_repair0.97485528
46MP0009046_muscle_twitch0.95953771
47MP0002734_abnormal_mechanical_nocicepti0.93184677
48MP0004782_abnormal_surfactant_physiolog0.92730409
49MP0001963_abnormal_hearing_physiology0.90068003
50MP0000383_abnormal_hair_follicle0.89373712
51MP0005647_abnormal_sex_gland0.88804355
52MP0003077_abnormal_cell_cycle0.88675229
53MP0003693_abnormal_embryo_hatching0.85864641
54MP0010234_abnormal_vibrissa_follicle0.85278893
55MP0000049_abnormal_middle_ear0.84883728
56MP0008995_early_reproductive_senescence0.83912202
57MP0002557_abnormal_social/conspecific_i0.80184633
58MP0005377_hearing/vestibular/ear_phenot0.79647157
59MP0003878_abnormal_ear_physiology0.79647157
60MP0003119_abnormal_digestive_system0.79204939
61MP0002089_abnormal_postnatal_growth/wei0.79046003
62MP0002736_abnormal_nociception_after0.77347105
63MP0005389_reproductive_system_phenotype0.76949565
64MP0005310_abnormal_salivary_gland0.76285969
65MP0009780_abnormal_chondrocyte_physiolo0.75701217
66MP0005409_darkened_coat_color0.75524159
67MP0003115_abnormal_respiratory_system0.74290618
68MP0006292_abnormal_olfactory_placode0.72838176
69MP0001501_abnormal_sleep_pattern0.70956082
70MP0000955_abnormal_spinal_cord0.70590157
71MP0002067_abnormal_sensory_capabilities0.69251473
72MP0004957_abnormal_blastocyst_morpholog0.64994666
73MP0000681_abnormal_thyroid_gland0.63793657
74MP0009745_abnormal_behavioral_response0.62509011
75MP0000762_abnormal_tongue_morphology0.61944610
76MP0000569_abnormal_digit_pigmentation0.61513034
77MP0005636_abnormal_mineral_homeostasis0.59725850
78MP0010771_integument_phenotype0.59222150
79MP0002184_abnormal_innervation0.58642127
80MP0010678_abnormal_skin_adnexa0.58619252
81MP0003936_abnormal_reproductive_system0.58032445
82MP0003011_delayed_dark_adaptation0.56990547
83MP0005646_abnormal_pituitary_gland0.56791274
84MP0010094_abnormal_chromosome_stability0.56081838
85MP0000377_abnormal_hair_follicle0.54979214
86MP0005083_abnormal_biliary_tract0.54330533
87MP0001881_abnormal_mammary_gland0.53935276
88MP0002909_abnormal_adrenal_gland0.53314766
89MP0003879_abnormal_hair_cell0.52625425
90MP0001764_abnormal_homeostasis0.52357832
91MP0002085_abnormal_embryonic_tissue0.51949524
92MP0005666_abnormal_adipose_tissue0.51699500
93MP0002102_abnormal_ear_morphology0.51088536
94MP0002733_abnormal_thermal_nociception0.50776783
95MP0004036_abnormal_muscle_relaxation0.50776774
96MP0005076_abnormal_cell_differentiation0.50128174
97MP0001666_abnormal_nutrient_absorption0.49915911
98MP0001968_abnormal_touch/_nociception0.49086838
99MP0005253_abnormal_eye_physiology0.47845405
100MP0001727_abnormal_embryo_implantation0.46542686
101MP0001324_abnormal_eye_pigmentation0.45465547
102MP0005551_abnormal_eye_electrophysiolog0.44575920
103MP0003699_abnormal_female_reproductive0.44029473
104MP0002269_muscular_atrophy0.41734324
105MP0003329_amyloid_beta_deposits0.41358190
106MP0003950_abnormal_plasma_membrane0.41141227
107MP0000462_abnormal_digestive_system0.40944478
108MP0000358_abnormal_cell_content/0.38552584
109MP0006036_abnormal_mitochondrial_physio0.38322717
110MP0003111_abnormal_nucleus_morphology0.38026533
111MP0000534_abnormal_ureter_morphology0.37392121
112MP0003786_premature_aging0.37048643
113MP0001545_abnormal_hematopoietic_system0.36202613
114MP0005397_hematopoietic_system_phenotyp0.36202613
115MP0001293_anophthalmia0.35963986
116MP0005451_abnormal_body_composition0.35358332
117MP0006072_abnormal_retinal_apoptosis0.33833176
118MP0004742_abnormal_vestibular_system0.32825248
119MP0005391_vision/eye_phenotype0.30793495
120MP0001986_abnormal_taste_sensitivity0.29304899
121MP0004811_abnormal_neuron_physiology0.29258208
122MP0009115_abnormal_fat_cell0.28790674
123MP0004133_heterotaxia0.27285894
124MP0001119_abnormal_female_reproductive0.26841941
125MP0003861_abnormal_nervous_system0.26765117
126MP0003787_abnormal_imprinting0.26503031
127MP0000751_myopathy0.26445310
128MP0003942_abnormal_urinary_system0.26202285
129MP0002152_abnormal_brain_morphology0.25049819
130MP0002295_abnormal_pulmonary_circulatio0.24617809
131MP0001661_extended_life_span0.24243088
132MP0004145_abnormal_muscle_electrophysio0.23649108
133MP0003633_abnormal_nervous_system0.23111696
134MP0009278_abnormal_bone_marrow0.22812810
135MP0001730_embryonic_growth_arrest0.22478442
136MP0002272_abnormal_nervous_system0.22439762
137MP0004270_analgesia0.22356390
138* MP0002169_no_abnormal_phenotype0.21671219
139* MP0002873_normal_phenotype0.21495120
140MP0003948_abnormal_gas_homeostasis0.21392337
141MP0002971_abnormal_brown_adipose0.21095088
142MP0008007_abnormal_cellular_replicative0.20649264
143MP0001440_abnormal_grooming_behavior0.20252701
144MP0002928_abnormal_bile_duct0.20209518
145MP0002229_neurodegeneration0.19472185
146MP0003631_nervous_system_phenotype0.19222194
147MP0008569_lethality_at_weaning0.19214309
148MP0002572_abnormal_emotion/affect_behav0.18776064
149MP0000604_amyloidosis0.18206218
150MP0002063_abnormal_learning/memory/cond0.16695397
151MP0003635_abnormal_synaptic_transmissio0.16436818
152MP0006035_abnormal_mitochondrial_morpho0.16265599
153MP0010307_abnormal_tumor_latency0.15484869
154* MP0000001_mammalian_phenotype0.14919692
155MP0008961_abnormal_basal_metabolism0.14192595
156MP0005379_endocrine/exocrine_gland_phen0.13882402
157MP0008057_abnormal_DNA_replication0.13671473
158MP0005423_abnormal_somatic_nervous0.13604118
159MP0000313_abnormal_cell_death0.13540716
160MP0004808_abnormal_hematopoietic_stem0.12618140
161MP0002106_abnormal_muscle_physiology0.12553232

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.36239239
2Abnormal respiratory epithelium morphology (HP:0012253)9.36239239
3Abnormal respiratory motile cilium physiology (HP:0012261)9.27069374
4Rhinitis (HP:0012384)7.45196966
5Abnormal ciliary motility (HP:0012262)7.28910266
6Chronic bronchitis (HP:0004469)7.23191146
7Infertility (HP:0000789)7.13993603
8Severe visual impairment (HP:0001141)6.80896290
9Nasal polyposis (HP:0100582)6.12682667
10Abnormality of the nasal mucosa (HP:0000433)4.98682223
11Male infertility (HP:0003251)4.92462555
12Bronchitis (HP:0012387)4.46340961
13Bronchiectasis (HP:0002110)4.32395487
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.23516325
15Nephronophthisis (HP:0000090)4.17688193
16Bony spicule pigmentary retinopathy (HP:0007737)4.03174372
17Amelogenesis imperfecta (HP:0000705)3.97308880
18Hyperkalemia (HP:0002153)3.91201036
19Attenuation of retinal blood vessels (HP:0007843)3.77116589
20Abnormal spermatogenesis (HP:0008669)3.73174518
21Hypoplastic ischia (HP:0003175)3.55412920
22Progressive sensorineural hearing impairment (HP:0000408)3.46269165
23Cone-rod dystrophy (HP:0000548)3.42761043
24Progressive cerebellar ataxia (HP:0002073)3.40747626
25Resting tremor (HP:0002322)3.39396798
26Chronic hepatic failure (HP:0100626)3.36836881
27Recurrent otitis media (HP:0000403)3.28684833
28Recurrent sinusitis (HP:0011108)3.26208406
29Abnormality of the renal medulla (HP:0100957)3.14269462
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.12277575
31Abnormality of the ischium (HP:0003174)3.07493682
32Tubulointerstitial nephritis (HP:0001970)2.92618095
33Impulsivity (HP:0100710)2.92449984
34Renovascular hypertension (HP:0100817)2.92251863
35Truncal obesity (HP:0001956)2.90130485
36Abnormality of the aortic arch (HP:0012303)2.85726337
37Genetic anticipation (HP:0003743)2.82839397
38Enlarged epiphyses (HP:0010580)2.78992108
39Abnormality of macular pigmentation (HP:0008002)2.76109246
40Postural instability (HP:0002172)2.67656564
41Recurrent bronchitis (HP:0002837)2.61774171
42Widely patent fontanelles and sutures (HP:0004492)2.59063203
43Aplasia/Hypoplasia of the earlobes (HP:0009906)2.58214852
44Septate vagina (HP:0001153)2.55233659
45Insulin-resistant diabetes mellitus (HP:0000831)2.52612495
46Myokymia (HP:0002411)2.49486509
47Abnormality of midbrain morphology (HP:0002418)2.47921184
48Molar tooth sign on MRI (HP:0002419)2.47921184
49Progressive hearing impairment (HP:0001730)2.44189001
50Abnormality of nail color (HP:0100643)2.42954004
51Tubular atrophy (HP:0000092)2.42088672
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39399315
53Lip pit (HP:0100267)2.38801062
54Cholecystitis (HP:0001082)2.38687303
55Abnormal gallbladder physiology (HP:0012438)2.38687303
56Potter facies (HP:0002009)2.36955383
57Facial shape deformation (HP:0011334)2.36955383
58Tubulointerstitial abnormality (HP:0001969)2.36332937
59Gonadotropin excess (HP:0000837)2.34251311
60Abnormality of the pubic bones (HP:0003172)2.32644726
61Abnormality of the parathyroid morphology (HP:0011766)2.31145689
62Unilateral renal agenesis (HP:0000122)2.29430708
63Medial flaring of the eyebrow (HP:0010747)2.27271425
64Abnormal rod and cone electroretinograms (HP:0008323)2.26631932
65Abnormality of dental color (HP:0011073)2.23965813
66Azoospermia (HP:0000027)2.22869997
67Hypoalphalipoproteinemia (HP:0003233)2.20439553
68Hypoplasia of the thymus (HP:0000778)2.15431803
69Abnormality of abdominal situs (HP:0011620)2.14530171
70Abdominal situs inversus (HP:0003363)2.14530171
71Menstrual irregularities (HP:0000858)2.14118122
72Generalized aminoaciduria (HP:0002909)2.12053313
73Dyschromatopsia (HP:0007641)2.11861251
74Hypoparathyroidism (HP:0000829)2.09828282
75Midline defect of the nose (HP:0004122)2.04434860
76Dynein arm defect of respiratory motile cilia (HP:0012255)13.6700575
77Absent/shortened dynein arms (HP:0200106)13.6700575
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9235873
79Abnormality of potassium homeostasis (HP:0011042)1.99138601
80Double outlet right ventricle (HP:0001719)1.96638745
81Congenital malformation of the right heart (HP:0011723)1.96638745
82Spastic tetraparesis (HP:0001285)1.96496072
83Esophageal varix (HP:0002040)1.94846618
84Choroideremia (HP:0001139)1.93937323
85Osteomalacia (HP:0002749)1.93077667
86Hypergonadotropic hypogonadism (HP:0000815)1.91746573
87Abnormality of the costochondral junction (HP:0000919)1.88632558
88Hypotrichosis (HP:0001006)1.86845787
89Concave nail (HP:0001598)1.86473839
90Decreased central vision (HP:0007663)1.85799298
91Abdominal distention (HP:0003270)1.84233589
92Subcapsular cataract (HP:0000523)1.83496916
93Ventricular tachycardia (HP:0004756)1.81459658
94Postaxial foot polydactyly (HP:0001830)1.80380165
95Tubulointerstitial fibrosis (HP:0005576)1.79735941
96Milia (HP:0001056)1.78990969
97Stage 5 chronic kidney disease (HP:0003774)1.78625725
98Skin pits (HP:0100276)1.77837369
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72730321
100Hypophosphatemic rickets (HP:0004912)1.71349163
101Bicornuate uterus (HP:0000813)1.69384823
102Abnormal drinking behavior (HP:0030082)1.68680270
103Polydipsia (HP:0001959)1.68680270
104Bowel incontinence (HP:0002607)1.66392703
105Underdeveloped nasal alae (HP:0000430)1.65105634
106Bell-shaped thorax (HP:0001591)1.63417924
107Pili torti (HP:0003777)1.61048915
108Flattened epiphyses (HP:0003071)1.60756545
109Hemorrhage of the eye (HP:0011885)1.60707973
110Abnormality of renal excretion (HP:0011036)1.59693328
111Heterotopia (HP:0002282)1.59480526
112Congenital hepatic fibrosis (HP:0002612)1.58494458
113Abnormality of the renal cortex (HP:0011035)1.58461688
114Acanthosis nigricans (HP:0000956)1.58397672
115Short ribs (HP:0000773)1.53969065
116Abnormal biliary tract physiology (HP:0012439)1.52720957
117Bile duct proliferation (HP:0001408)1.52720957
118Fibular hypoplasia (HP:0003038)1.52459257
119Decreased electroretinogram (ERG) amplitude (HP:0000654)1.51685601
120Abnormality of the dental root (HP:0006486)1.50314359
121Taurodontia (HP:0000679)1.50314359
122Abnormality of permanent molar morphology (HP:0011071)1.50314359
123Oculomotor apraxia (HP:0000657)1.48484525
124Abnormality of the dental pulp (HP:0006479)1.46664452
125Renal dysplasia (HP:0000110)1.44373165
126Neurofibrillary tangles (HP:0002185)1.43476038
127Bundle branch block (HP:0011710)1.43422296
128Aplasia/Hypoplasia of the lens (HP:0008063)1.42872047
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40215491
130Absent epiphyses (HP:0010577)1.40215491
131Abnormality of molar (HP:0011077)1.39904370
132Abnormality of molar morphology (HP:0011070)1.39904370
133Hemiparesis (HP:0001269)1.39667267
134Abnormality of dentin (HP:0010299)1.38639090
135Postaxial hand polydactyly (HP:0001162)1.37850018
136Facial cleft (HP:0002006)1.36476463
137Abnormal urine output (HP:0012590)1.33719273
138Exercise-induced myalgia (HP:0003738)1.33198902
139Sensory axonal neuropathy (HP:0003390)1.32552740
140Fatigable weakness (HP:0003473)1.32292092
141Abnormality of the neuromuscular junction (HP:0003398)1.32292092
142Asymmetric septal hypertrophy (HP:0001670)1.30061383
143Easy fatigability (HP:0003388)1.27857643
144Broad distal phalanx of finger (HP:0009836)1.27437545
145Short femoral neck (HP:0100864)1.26300677
146Constricted visual fields (HP:0001133)1.26191281
147Pancreatic fibrosis (HP:0100732)1.23819238
148Cystic liver disease (HP:0006706)1.23572601
149Abnormality of the lower motor neuron (HP:0002366)1.21995624
150Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.21204904
151Deformed sella turcica (HP:0002681)1.20446602
152Impaired proprioception (HP:0010831)1.19273389
153Nephropathy (HP:0000112)1.17993785
154Myoglobinuria (HP:0002913)1.16942807
155Cerebral inclusion bodies (HP:0100314)1.16369110
156Short thorax (HP:0010306)1.15186738
157Rhabdomyolysis (HP:0003201)1.14552107
158Congenital primary aphakia (HP:0007707)1.13963000
159Gait imbalance (HP:0002141)1.13820533
160Chronic sinusitis (HP:0011109)1.11848222
161Transposition of the great arteries (HP:0001669)1.11625282
162Abnormal connection of the cardiac segments (HP:0011545)1.11625282
163Abnormal ventriculo-arterial connection (HP:0011563)1.11625282
164Polyuria (HP:0000103)1.11330107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.06453703
2PDK48.06453703
3INSRR6.60911316
4TESK16.50192295
5PRKD35.41957107
6PDK25.18588833
7ICK4.53128078
8TRIB32.90696449
9DDR22.81803339
10CDK122.42660868
11PTK2B2.18766946
12MAP4K22.01971042
13BRD42.00046665
14WNK41.99532137
15STK391.93037935
16MAP2K21.89132790
17PNCK1.86342142
18STK381.78525634
19MST1R1.71863278
20CDK71.56862323
21NEK21.54820785
22DYRK1B1.51537202
23SMG11.45969513
24EPHA21.42793014
25LATS21.39700096
26RPS6KB21.32817933
27PLK21.28712243
28PDK11.18104975
29SIK11.17041820
30ARAF1.13102080
31PBK1.12997831
32MAPKAPK31.11842041
33RPS6KA21.10137245
34CCNB11.09466153
35PKN21.03870777
36KSR21.01635716
37MAPK150.96925957
38TESK20.96441613
39DYRK30.91070840
40RIPK40.88686446
41MET0.88208884
42NME10.84056229
43WNK10.77682738
44CHUK0.73984797
45PDPK10.73504952
46IRAK10.73477082
47TYRO30.70899787
48SIK20.70060106
49MAP2K10.66217263
50CAMK1D0.65879507
51STK30.64395461
52PINK10.64232677
53PHKG10.63869218
54PHKG20.63869218
55TTK0.58379251
56MAP3K80.57768125
57PASK0.57154298
58MUSK0.57011210
59CHEK20.56126956
60CAMK10.53981911
61TNK20.53456652
62MAP2K60.51821691
63MAP3K20.51257405
64RPS6KA60.50528406
65RPS6KC10.50041476
66RPS6KL10.50041476
67PRKCI0.46378438
68STK38L0.46028403
69PRKCG0.45827336
70PAK10.42688045
71CDK90.42555909
72CAMK2G0.42326725
73PIK3CG0.40333541
74NTRK20.40093943
75CAMK2B0.39861822
76CAMK1G0.39042743
77IRAK20.38908304
78EEF2K0.38296281
79UHMK10.37440031
80CHEK10.36768014
81GRK10.36684805
82RIPK10.33131517
83MAPK10.33127972
84PAK20.32797889
85CAMK40.32117886
86PIK3CA0.30749631
87MAPK140.29505211
88MAPK110.29048641
89ATM0.28255377
90MAP3K10.27524700
91LMTK20.26958395
92BRAF0.26949058
93PRKAA20.25773478
94SRPK10.25087173
95MAP3K40.24883750
96NEK60.24345278
97MAP3K130.24265337
98MAPKAPK50.23934218
99CAMK2D0.23852598
100MARK20.23815112
101ROCK10.23738341
102TRIM280.23437528
103MAP3K90.22812177
104ATR0.22665028
105CAMKK10.21383348
106SGK2230.20887893
107SGK4940.20887893
108WEE10.20276446
109MAPK100.20097499
110PLK40.19998528
111BMX0.19791620
112PRKCZ0.19572741
113MTOR0.19187739
114PAK40.17936255
115BRSK20.17806643
116CDK150.16975772
117PLK10.16714391
118PRKAA10.16393309
119CDK180.15035547
120MAP3K100.12619631
121BRSK10.12375144
122CDK11A0.12179866
123PRKCQ0.11877696
124CDK30.11805858
125MAP2K70.11249337
126RPS6KB10.10859036
127NTRK30.10697654
128CDK140.09194300
129CSNK2A10.08902158
130CAMK2A0.07484558
131PAK60.07260785
132GSK3B0.07103121
133CLK10.05134960
134PRKCB0.04367011
135PRKG10.04216035
136PRKACG0.03263560
137RPS6KA10.03188986
138PKN10.02948987
139PRKCD0.02677540
140CDK10.02595165
141OBSCN0.02554747
142AURKA0.02281382
143CSNK1D0.01547536
144CSNK2A20.01270938
145CDK20.01073115
146MARK30.00894817
147PRKCA0.00827499
148PRKG20.00478550
149EPHA40.00306000
150RPS6KA3-0.0255973
151CDK4-0.0224972
152CDC7-0.0073286
153MAPK8-0.0052249
154PRKACB-0.0045639
155AKT3-0.0029114
156STK11-0.0016970
157MAP3K5-0.0012384
158PRKACA-0.0009197
159YES1-0.0006250

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.61939223
2Fatty acid biosynthesis_Homo sapiens_hsa000614.59065802
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.42472739
4Vitamin B6 metabolism_Homo sapiens_hsa007504.06129501
5Pyruvate metabolism_Homo sapiens_hsa006203.25833069
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.06637162
7Linoleic acid metabolism_Homo sapiens_hsa005912.98256354
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.71757126
9Olfactory transduction_Homo sapiens_hsa047402.65436783
10Glucagon signaling pathway_Homo sapiens_hsa049222.53251803
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.47218511
12Basal transcription factors_Homo sapiens_hsa030222.46789358
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.43100372
14Propanoate metabolism_Homo sapiens_hsa006402.38016990
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88179594
16Glycerolipid metabolism_Homo sapiens_hsa005611.85895768
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.85336775
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.76152007
19Amphetamine addiction_Homo sapiens_hsa050311.74130499
20Selenocompound metabolism_Homo sapiens_hsa004501.73527163
21PPAR signaling pathway_Homo sapiens_hsa033201.66966444
22Fructose and mannose metabolism_Homo sapiens_hsa000511.64064202
23Oocyte meiosis_Homo sapiens_hsa041141.62890710
24Butanoate metabolism_Homo sapiens_hsa006501.62794349
25Cardiac muscle contraction_Homo sapiens_hsa042601.60672985
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.57469042
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49694836
28Mineral absorption_Homo sapiens_hsa049781.46839456
29Fanconi anemia pathway_Homo sapiens_hsa034601.45023799
30Dorso-ventral axis formation_Homo sapiens_hsa043201.43873300
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.42874546
32Ether lipid metabolism_Homo sapiens_hsa005651.41067074
33Phototransduction_Homo sapiens_hsa047441.39100835
34Folate biosynthesis_Homo sapiens_hsa007901.35835468
35Pentose phosphate pathway_Homo sapiens_hsa000301.35503025
36Fatty acid metabolism_Homo sapiens_hsa012121.26771103
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25750416
38Fat digestion and absorption_Homo sapiens_hsa049751.25326247
39Carbon metabolism_Homo sapiens_hsa012001.23339219
40Collecting duct acid secretion_Homo sapiens_hsa049661.22843196
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19918058
42Fatty acid degradation_Homo sapiens_hsa000711.15927785
43Purine metabolism_Homo sapiens_hsa002301.15388730
44Huntingtons disease_Homo sapiens_hsa050161.13260572
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.13147626
46Renin secretion_Homo sapiens_hsa049241.11101590
47Morphine addiction_Homo sapiens_hsa050321.08218950
48Acute myeloid leukemia_Homo sapiens_hsa052211.05686445
49Ovarian steroidogenesis_Homo sapiens_hsa049131.04996656
50Tight junction_Homo sapiens_hsa045301.03426362
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98905878
52Cholinergic synapse_Homo sapiens_hsa047250.97212930
53mRNA surveillance pathway_Homo sapiens_hsa030150.97000747
54Antigen processing and presentation_Homo sapiens_hsa046120.94839075
55mTOR signaling pathway_Homo sapiens_hsa041500.93193999
56Glutathione metabolism_Homo sapiens_hsa004800.92551704
57Serotonergic synapse_Homo sapiens_hsa047260.89859382
58Insulin secretion_Homo sapiens_hsa049110.89624739
59Hedgehog signaling pathway_Homo sapiens_hsa043400.89294010
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89154522
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89082569
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87604447
63Long-term potentiation_Homo sapiens_hsa047200.87090645
64Lysine degradation_Homo sapiens_hsa003100.86923483
65Arachidonic acid metabolism_Homo sapiens_hsa005900.86903739
66Notch signaling pathway_Homo sapiens_hsa043300.82275311
67ErbB signaling pathway_Homo sapiens_hsa040120.82077141
68RNA transport_Homo sapiens_hsa030130.81799373
69Long-term depression_Homo sapiens_hsa047300.81368940
70Arginine and proline metabolism_Homo sapiens_hsa003300.81274793
71Phenylalanine metabolism_Homo sapiens_hsa003600.80270712
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79803448
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77389167
74MAPK signaling pathway_Homo sapiens_hsa040100.75949232
75Choline metabolism in cancer_Homo sapiens_hsa052310.74320654
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73872649
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73857133
78Sulfur relay system_Homo sapiens_hsa041220.73210537
79Synaptic vesicle cycle_Homo sapiens_hsa047210.72289512
80Biosynthesis of amino acids_Homo sapiens_hsa012300.72237185
81Thyroid hormone synthesis_Homo sapiens_hsa049180.72221132
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.72086008
83Estrogen signaling pathway_Homo sapiens_hsa049150.72005911
84Chemical carcinogenesis_Homo sapiens_hsa052040.69050494
85Insulin signaling pathway_Homo sapiens_hsa049100.68305018
86Oxytocin signaling pathway_Homo sapiens_hsa049210.66479470
87Hippo signaling pathway_Homo sapiens_hsa043900.64786704
88Calcium signaling pathway_Homo sapiens_hsa040200.64255867
89Endometrial cancer_Homo sapiens_hsa052130.62960124
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60275127
91Salivary secretion_Homo sapiens_hsa049700.60202005
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.59469854
93Bile secretion_Homo sapiens_hsa049760.56821162
94GABAergic synapse_Homo sapiens_hsa047270.56499460
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53268554
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52940985
97Gastric acid secretion_Homo sapiens_hsa049710.52901919
98Pancreatic secretion_Homo sapiens_hsa049720.52230912
99Legionellosis_Homo sapiens_hsa051340.52115530
100Arginine biosynthesis_Homo sapiens_hsa002200.51727789
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.51449241
102Sulfur metabolism_Homo sapiens_hsa009200.51260455
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.51138988
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50893349
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49713205
106Pyrimidine metabolism_Homo sapiens_hsa002400.48019725
107Taste transduction_Homo sapiens_hsa047420.47180553
108Protein digestion and absorption_Homo sapiens_hsa049740.46236136
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44753355
110Bladder cancer_Homo sapiens_hsa052190.43860164
111Prostate cancer_Homo sapiens_hsa052150.42816125
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42806444
113Insulin resistance_Homo sapiens_hsa049310.42773839
114Base excision repair_Homo sapiens_hsa034100.42031554
115ABC transporters_Homo sapiens_hsa020100.41997138
116Circadian entrainment_Homo sapiens_hsa047130.40504315
117Metabolic pathways_Homo sapiens_hsa011000.39933106
118Endocytosis_Homo sapiens_hsa041440.39337816
119MicroRNAs in cancer_Homo sapiens_hsa052060.37982965
120Thyroid cancer_Homo sapiens_hsa052160.37898188
121AMPK signaling pathway_Homo sapiens_hsa041520.37595008
122Cell cycle_Homo sapiens_hsa041100.37354600
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37014357
124Glioma_Homo sapiens_hsa052140.36804936
125cAMP signaling pathway_Homo sapiens_hsa040240.35819975
126Axon guidance_Homo sapiens_hsa043600.35810431
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35766160
128Inositol phosphate metabolism_Homo sapiens_hsa005620.35551431
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34166981
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33205182
131VEGF signaling pathway_Homo sapiens_hsa043700.32913559
132Non-small cell lung cancer_Homo sapiens_hsa052230.32400987
133Renin-angiotensin system_Homo sapiens_hsa046140.32203033
134Cocaine addiction_Homo sapiens_hsa050300.28586776
135Systemic lupus erythematosus_Homo sapiens_hsa053220.27170471
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22784823
137Glutamatergic synapse_Homo sapiens_hsa047240.22588314
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19576493
139Wnt signaling pathway_Homo sapiens_hsa043100.18678868
140Alcoholism_Homo sapiens_hsa050340.18531599
141Type II diabetes mellitus_Homo sapiens_hsa049300.18327039
142Sphingolipid metabolism_Homo sapiens_hsa006000.17187170
143HIF-1 signaling pathway_Homo sapiens_hsa040660.14752772
144Nicotine addiction_Homo sapiens_hsa050330.12829453
145Dopaminergic synapse_Homo sapiens_hsa047280.11725869
146B cell receptor signaling pathway_Homo sapiens_hsa046620.10598380

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