THEGL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.73845342
2motile cilium assembly (GO:0044458)9.60989968
3response to pheromone (GO:0019236)9.55366792
4spermatid development (GO:0007286)9.35650346
5plasma membrane fusion (GO:0045026)9.18018780
6reproduction (GO:0000003)8.98383887
7regulation of cilium movement (GO:0003352)8.91327755
8piRNA metabolic process (GO:0034587)8.82340832
9cilium movement (GO:0003341)8.65576640
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.80458694
11male meiosis (GO:0007140)7.66351874
12single fertilization (GO:0007338)7.39391983
13synaptonemal complex organization (GO:0070193)7.38161197
14synaptonemal complex assembly (GO:0007130)7.13460038
15sperm capacitation (GO:0048240)7.00795321
16negative regulation of inclusion body assembly (GO:0090084)6.97162762
17rRNA methylation (GO:0031167)6.71340630
18microtubule depolymerization (GO:0007019)6.64664930
19spermatogenesis (GO:0007283)6.56917685
20male gamete generation (GO:0048232)6.54854986
21fertilization (GO:0009566)6.45416059
22gamete generation (GO:0007276)6.12029622
23organic cation transport (GO:0015695)6.04155005
24rRNA modification (GO:0000154)6.00202322
25DNA methylation involved in gamete generation (GO:0043046)5.65526440
26regulation of inclusion body assembly (GO:0090083)5.63502073
27male meiosis I (GO:0007141)5.51091380
28germ cell development (GO:0007281)5.40679255
29ventricular system development (GO:0021591)5.38853953
30microtubule severing (GO:0051013)5.38206716
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.31228544
32cellular ketone body metabolic process (GO:0046950)5.29053407
33regulation of microtubule-based movement (GO:0060632)5.14772710
34centriole replication (GO:0007099)5.09173114
35calcium ion-dependent exocytosis (GO:0017156)5.04088599
36protein targeting to Golgi (GO:0000042)4.97689135
37chromosome organization involved in meiosis (GO:0070192)4.93647011
38chromosome condensation (GO:0030261)4.83575287
39multicellular organismal reproductive process (GO:0048609)4.83078424
40phosphatidylethanolamine biosynthetic process (GO:0006646)4.74472709
41establishment of protein localization to Golgi (GO:0072600)4.73309889
42cell recognition (GO:0008037)4.67236550
43retrograde transport, vesicle recycling within Golgi (GO:0000301)4.64886637
44ketone body metabolic process (GO:1902224)4.64548790
45meiotic nuclear division (GO:0007126)4.63835883
46DNA packaging (GO:0006323)4.60813123
47meiotic cell cycle (GO:0051321)4.58588080
48spermatid nucleus differentiation (GO:0007289)4.54059212
49meiosis I (GO:0007127)4.50315398
50phosphatidylethanolamine metabolic process (GO:0046337)4.41766724
51seminiferous tubule development (GO:0072520)4.40797913
52left/right pattern formation (GO:0060972)4.36729260
53glycerol ether metabolic process (GO:0006662)4.32604011
54protein polyglutamylation (GO:0018095)4.29426852
55coenzyme catabolic process (GO:0009109)3.99384793
56ether metabolic process (GO:0018904)3.99015430
57multicellular organismal development (GO:0007275)3.80138663
58protein localization to Golgi apparatus (GO:0034067)3.68897258
59monoubiquitinated protein deubiquitination (GO:0035520)3.65766776
60regulation of spindle checkpoint (GO:0090231)3.62688787
61single strand break repair (GO:0000012)3.61773805
62cranial nerve morphogenesis (GO:0021602)3.61254708
63chaperone-mediated protein complex assembly (GO:0051131)3.58829591
64proteasome assembly (GO:0043248)3.55801224
65microtubule nucleation (GO:0007020)3.55786067
66protein localization to cilium (GO:0061512)3.53870356
67microtubule polymerization or depolymerization (GO:0031109)3.46857450
68genitalia morphogenesis (GO:0035112)3.46840420
69ribosome assembly (GO:0042255)3.41720806
70positive regulation of Rab GTPase activity (GO:0032851)3.40900913
71regulation of Rab GTPase activity (GO:0032313)3.40900913
72mesenchymal cell differentiation involved in renal system development (GO:2001012)3.39551251
73mesenchymal cell differentiation involved in kidney development (GO:0072161)3.39551251
74polyamine biosynthetic process (GO:0006596)3.36513832
75protein-DNA complex disassembly (GO:0032986)3.35342534
76nucleosome disassembly (GO:0006337)3.35342534
77negative regulation of Rho protein signal transduction (GO:0035024)3.35043444
78regulation of transcription involved in cell fate commitment (GO:0060850)3.33649134
79meiotic cell cycle process (GO:1903046)3.27921617
80mitotic sister chromatid cohesion (GO:0007064)3.25621395
81axoneme assembly (GO:0035082)3.24032694
82gene silencing by RNA (GO:0031047)3.23211724
83nucleoside diphosphate phosphorylation (GO:0006165)3.21352075
84DNA conformation change (GO:0071103)3.19683513
85cilium organization (GO:0044782)3.18277559
86glomerular visceral epithelial cell development (GO:0072015)3.16884481
87intraciliary transport (GO:0042073)3.16443625
88interferon-gamma secretion (GO:0072643)3.13091728
89regulation of meiosis I (GO:0060631)3.12770592
90chromatin silencing (GO:0006342)3.11734986
91protein depolymerization (GO:0051261)3.09158053
92mitochondrial fission (GO:0000266)3.08440009
93cilium assembly (GO:0042384)3.06880058
94protein refolding (GO:0042026)3.06542802
95nucleus organization (GO:0006997)3.05753885
96sexual reproduction (GO:0019953)3.05161439
97microtubule-based movement (GO:0007018)3.03870467
98RNA destabilization (GO:0050779)3.00934950
99cilium morphogenesis (GO:0060271)3.00751927
100protein retention in ER lumen (GO:0006621)2.98265363
101glomerular epithelial cell development (GO:0072310)2.97549090
102peptidyl-threonine dephosphorylation (GO:0035970)2.97179848
103protein K11-linked deubiquitination (GO:0035871)2.95881626
104amino-acid betaine transport (GO:0015838)2.94179771
105carnitine transport (GO:0015879)2.94179771
106polyol catabolic process (GO:0046174)2.91528247
107synapsis (GO:0007129)2.87048444
108cellular component assembly involved in morphogenesis (GO:0010927)2.85302480
109negative regulation of organelle assembly (GO:1902116)2.84453699
110peptidyl-glutamic acid modification (GO:0018200)2.82523014
111multicellular organismal movement (GO:0050879)2.82073355
112musculoskeletal movement (GO:0050881)2.82073355
113membrane protein intracellular domain proteolysis (GO:0031293)2.82066698
114nuclear pore complex assembly (GO:0051292)2.80519474
115glycolytic process (GO:0006096)2.79444662
116regulation of acrosome reaction (GO:0060046)2.79182884
117carnitine transmembrane transport (GO:1902603)2.78673185
118centriole assembly (GO:0098534)2.77594530
119RNA localization (GO:0006403)2.77206423
120cofactor catabolic process (GO:0051187)2.76770540
121regulation of cilium assembly (GO:1902017)2.75554990
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73499060
123alditol metabolic process (GO:0019400)2.73315159
124GTP biosynthetic process (GO:0006183)2.73136726
125regulation of centriole replication (GO:0046599)2.71922168
126RNA methylation (GO:0001510)2.68001663
127pattern specification involved in kidney development (GO:0061004)2.65211961
128gene silencing (GO:0016458)2.59651036
129histone exchange (GO:0043486)2.59529906
130positive regulation of mitochondrial fission (GO:0090141)2.58020361
131protein localization to chromosome, centromeric region (GO:0071459)2.57662334
132positive regulation of DNA-dependent DNA replication (GO:2000105)2.56600364
133outer ear morphogenesis (GO:0042473)2.54600473
134regulation of somitogenesis (GO:0014807)2.53005865
135response to acidic pH (GO:0010447)2.52499427
136sperm motility (GO:0030317)13.1928451
137fusion of sperm to egg plasma membrane (GO:0007342)12.0863594
138acrosome reaction (GO:0007340)11.4141285
139sperm-egg recognition (GO:0035036)10.9111158
140multicellular organism reproduction (GO:0032504)10.6787601
141cell wall macromolecule catabolic process (GO:0016998)10.6006140
142cell wall macromolecule metabolic process (GO:0044036)10.6006140
143cilium or flagellum-dependent cell motility (GO:0001539)10.5578568
144axonemal dynein complex assembly (GO:0070286)10.4332667
145acrosome assembly (GO:0001675)10.2246061
146binding of sperm to zona pellucida (GO:0007339)10.1626861
147epithelial cilium movement (GO:0003351)10.1080016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.93088087
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.07379990
3EZH2_22144423_ChIP-Seq_EOC_Human4.97361393
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.51581285
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.11483735
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80278221
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.79471701
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54861610
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52369735
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.51599436
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50406914
12VDR_22108803_ChIP-Seq_LS180_Human2.46346577
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45015399
14ELF1_20517297_ChIP-Seq_JURKAT_Human2.41734546
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.34910749
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.25413952
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.25218343
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.11971655
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.02500781
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99726042
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94426657
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.93689296
23FUS_26573619_Chip-Seq_HEK293_Human1.91149188
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90378384
25HNFA_21074721_ChIP-Seq_CACO-2_Human1.89812799
26YY1_22570637_ChIP-Seq_MALME-3M_Human1.89560940
27ERA_21632823_ChIP-Seq_H3396_Human1.89362602
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86573945
29PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.85746779
30E2F7_22180533_ChIP-Seq_HELA_Human1.84465376
31RBPJ_21746931_ChIP-Seq_IB4_Human1.84429741
32STAT1_17558387_ChIP-Seq_HELA_Human1.83531873
33CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.82174065
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.81279784
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.76501525
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74428837
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.73458678
38RAC3_21632823_ChIP-Seq_H3396_Human1.71620008
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.68161382
40CBX2_22325352_ChIP-Seq_293T-Rex_Human1.67295201
41ZNF274_21170338_ChIP-Seq_K562_Hela1.65748629
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63217472
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62511615
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62101948
45PHF8_20622853_ChIP-Seq_HELA_Human1.61980215
46FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61278521
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60567330
48GATA6_21074721_ChIP-Seq_CACO-2_Human1.58874673
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56565956
50PHF8_20622854_ChIP-Seq_HELA_Human1.55939765
51E2F1_20622854_ChIP-Seq_HELA_Human1.54840975
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.54465050
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53038264
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.52369201
55SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52098715
56BCL6_27268052_Chip-Seq_Bcells_Human1.50553623
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.49220843
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.49069385
59GATA3_21867929_ChIP-Seq_CD8_Mouse1.48933657
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.48927743
61BCOR_27268052_Chip-Seq_Bcells_Human1.45020742
62KDM2B_26808549_Chip-Seq_REH_Human1.43317233
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.42469714
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42056438
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40882229
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40443164
67MYC_19829295_ChIP-Seq_ESCs_Human1.38420224
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37450273
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.37195797
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36093498
71GATA3_21867929_ChIP-Seq_TH1_Mouse1.36061499
72GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.35881344
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.35684857
74GATA1_19941826_ChIP-Seq_K562_Human1.35549048
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.35533881
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34641764
77SALL4_22934838_ChIP-ChIP_CD34+_Human1.34591043
78P300_27268052_Chip-Seq_Bcells_Human1.33311440
79FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33090067
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33057683
81TAF2_19829295_ChIP-Seq_ESCs_Human1.32464034
82KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.32305304
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32071538
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.32008891
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31927963
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31326687
87ER_23166858_ChIP-Seq_MCF-7_Human1.31259573
88CBP_20019798_ChIP-Seq_JUKART_Human1.30665759
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30665759
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29708345
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29708345
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29563625
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28717121
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27455595
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.26485808
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24723810
97P53_21459846_ChIP-Seq_SAOS-2_Human1.23949984
98RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23153856
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22833191
100SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.22048470
101OCT4_20526341_ChIP-Seq_ESCs_Human1.21479047
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20944600
103CSB_26484114_Chip-Seq_FIBROBLAST_Human1.20671247
104REST_21632747_ChIP-Seq_MESCs_Mouse1.20137939
105NFYA_21822215_ChIP-Seq_K562_Human1.19619553
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19503643
107SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19344127
108SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19191220
109P68_20966046_ChIP-Seq_HELA_Human1.19100920
110LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.18327108
111GF1_26923725_Chip-Seq_HPCs_Mouse1.17804259
112FOXP1_21924763_ChIP-Seq_HESCs_Human1.17623997
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.17483818
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.16918230
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.16259227
116RNF2_27304074_Chip-Seq_NSC_Mouse1.16237290
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13835771
118ERG_20517297_ChIP-Seq_VCAP_Human1.12955009
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12901887
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12302398
121RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11142210
122SMC4_20622854_ChIP-Seq_HELA_Human1.11096787
123E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10680743
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10215934
125TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09084601
126OCT4_18555785_Chip-Seq_ESCs_Mouse1.08607487
127CTCF_27219007_Chip-Seq_Bcells_Human1.08169921
128CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07287498
129SPI1_26923725_Chip-Seq_HPCs_Mouse1.07262055
130TP63_22573176_ChIP-Seq_HFKS_Human1.06781921
131EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06187128
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05955279
133CEBPB_22108803_ChIP-Seq_LS180_Human1.05516387
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05030500
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04251906
136EZH2_27294783_Chip-Seq_NPCs_Mouse1.04152906
137P53_22387025_ChIP-Seq_ESCs_Mouse1.04119547
138KDM5A_27292631_Chip-Seq_BREAST_Human1.04077633
139MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03957541
140ESET_19884257_ChIP-Seq_ESCs_Mouse1.03897202
141GATA3_21878914_ChIP-Seq_MCF-7_Human1.02994288
142XRN2_22483619_ChIP-Seq_HELA_Human1.02249403
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02194181
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01869461
145NANOG_19829295_ChIP-Seq_ESCs_Human1.01539526
146SOX2_19829295_ChIP-Seq_ESCs_Human1.01539526
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01527474
148RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00508338
149NFYB_21822215_ChIP-Seq_K562_Human1.00480361
150TBL1_22424771_ChIP-Seq_293T_Human0.99305097
151TAF15_26573619_Chip-Seq_HEK293_Human0.99299573
152KLF4_18555785_Chip-Seq_ESCs_Mouse0.98975403
153OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98726683
154PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98598102
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98261381
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.98185086
157TP53_18474530_ChIP-ChIP_U2OS_Human0.97394791
158ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97107561
159ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95761116
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.95570866
161CMYC_18555785_Chip-Seq_ESCs_Mouse0.95526684
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95500661
163RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94759287
164TTF2_22483619_ChIP-Seq_HELA_Human0.94579652
165NANOG_20526341_ChIP-Seq_ESCs_Human0.92888086
166GF1B_26923725_Chip-Seq_HPCs_Mouse0.92760784
167SMAD4_21741376_ChIP-Seq_EPCs_Human0.92666024
168P300_18555785_Chip-Seq_ESCs_Mouse0.92571903
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92171623
170GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91335022
171EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91224843
172STAT3_18555785_Chip-Seq_ESCs_Mouse0.91195434
173LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90734884
174ETV1_20927104_ChIP-Seq_GIST48_Human0.90536393
175EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89437388
176CTCF_20526341_ChIP-Seq_ESCs_Human0.88988611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.89943938
2MP0001929_abnormal_gametogenesis5.63594544
3MP0008877_abnormal_DNA_methylation4.60554401
4MP0002210_abnormal_sex_determination3.66796518
5MP0002161_abnormal_fertility/fecundity3.40849051
6MP0002653_abnormal_ependyma_morphology3.17036197
7MP0001145_abnormal_male_reproductive3.02496173
8MP0000653_abnormal_sex_gland2.79717263
9MP0009697_abnormal_copulation2.76799741
10MP0002822_catalepsy2.53113946
11MP0005670_abnormal_white_adipose2.48162222
12MP0000678_abnormal_parathyroid_gland2.45068365
13MP0003646_muscle_fatigue2.44278556
14MP0003656_abnormal_erythrocyte_physiolo2.29945444
15MP0005083_abnormal_biliary_tract2.24977725
16MP0005410_abnormal_fertilization15.4851006
17MP0004147_increased_porphyrin_level1.96239061
18MP0001348_abnormal_lacrimal_gland1.77683460
19MP0002160_abnormal_reproductive_system1.73475237
20MP0002282_abnormal_trachea_morphology1.57471669
21MP0009053_abnormal_anal_canal1.56312976
22MP0001485_abnormal_pinna_reflex1.48458582
23MP0005623_abnormal_meninges_morphology1.45514508
24MP0000681_abnormal_thyroid_gland1.41949969
25MP0001984_abnormal_olfaction1.38089872
26MP0002127_abnormal_cardiovascular_syste1.36039673
27MP0002735_abnormal_chemical_nociception1.32549561
28MP0002102_abnormal_ear_morphology1.21940101
29MP0004233_abnormal_muscle_weight1.13196111
30MP0005367_renal/urinary_system_phenotyp1.12911554
31MP0000516_abnormal_urinary_system1.12911554
32MP0006276_abnormal_autonomic_nervous1.11066216
33MP0010094_abnormal_chromosome_stability1.08339506
34MP0008995_early_reproductive_senescence1.05309705
35MP0001765_abnormal_ion_homeostasis1.04907340
36MP0005451_abnormal_body_composition1.00385343
37MP0005389_reproductive_system_phenotype0.99712293
38MP0001188_hyperpigmentation0.99693275
39MP0003718_maternal_effect0.98610630
40MP0006036_abnormal_mitochondrial_physio0.98359003
41MP0008058_abnormal_DNA_repair0.98252623
42MP0001905_abnormal_dopamine_level0.96501299
43MP0001299_abnormal_eye_distance/0.96420111
44MP0003699_abnormal_female_reproductive0.93990852
45MP0005647_abnormal_sex_gland0.92519746
46MP0001963_abnormal_hearing_physiology0.86274616
47MP0008789_abnormal_olfactory_epithelium0.84751406
48MP0003011_delayed_dark_adaptation0.84095506
49MP0004085_abnormal_heartbeat0.84084689
50MP0005332_abnormal_amino_acid0.83986567
51MP0005084_abnormal_gallbladder_morpholo0.83922722
52MP0003111_abnormal_nucleus_morphology0.81689591
53MP0001119_abnormal_female_reproductive0.80607882
54MP0001486_abnormal_startle_reflex0.80147162
55MP0000026_abnormal_inner_ear0.75863263
56MP0000049_abnormal_middle_ear0.74654534
57MP0004859_abnormal_synaptic_plasticity0.73386633
58MP0003137_abnormal_impulse_conducting0.72283433
59MP0003787_abnormal_imprinting0.70647589
60MP0006292_abnormal_olfactory_placode0.70139042
61MP0003115_abnormal_respiratory_system0.67970206
62MP0000015_abnormal_ear_pigmentation0.67579904
63MP0002177_abnormal_outer_ear0.67536322
64MP0009046_muscle_twitch0.66312909
65MP0004510_myositis0.63377138
66MP0002229_neurodegeneration0.62519837
67MP0006035_abnormal_mitochondrial_morpho0.60893998
68MP0005408_hypopigmentation0.59852969
69MP0000955_abnormal_spinal_cord0.59740745
70MP0005377_hearing/vestibular/ear_phenot0.59545096
71MP0003878_abnormal_ear_physiology0.59545096
72MP0002234_abnormal_pharynx_morphology0.59524912
73MP0005646_abnormal_pituitary_gland0.57029128
74MP0005248_abnormal_Harderian_gland0.54821495
75MP0002080_prenatal_lethality0.54810221
76MP0000749_muscle_degeneration0.54033026
77MP0005171_absent_coat_pigmentation0.53605764
78MP0000467_abnormal_esophagus_morphology0.53464777
79MP0002067_abnormal_sensory_capabilities0.53001460
80MP0001879_abnormal_lymphatic_vessel0.52541256
81MP0004142_abnormal_muscle_tone0.51987196
82MP0005636_abnormal_mineral_homeostasis0.51639850
83MP0008007_abnormal_cellular_replicative0.51510597
84MP0003950_abnormal_plasma_membrane0.51114692
85MP0003077_abnormal_cell_cycle0.50704432
86MP0003693_abnormal_embryo_hatching0.50692765
87MP0003942_abnormal_urinary_system0.49979591
88MP0003136_yellow_coat_color0.48788597
89MP0002733_abnormal_thermal_nociception0.48511163
90MP0000569_abnormal_digit_pigmentation0.48229363
91MP0005376_homeostasis/metabolism_phenot0.47725690
92MP0002928_abnormal_bile_duct0.47549968
93MP0005666_abnormal_adipose_tissue0.47456118
94MP0003879_abnormal_hair_cell0.45764412
95MP0005395_other_phenotype0.44024882
96MP0000534_abnormal_ureter_morphology0.42751896
97MP0004036_abnormal_muscle_relaxation0.41091349
98MP0004145_abnormal_muscle_electrophysio0.40971829
99MP0003786_premature_aging0.40951549
100MP0002736_abnormal_nociception_after0.39508106
101MP0001324_abnormal_eye_pigmentation0.37536573
102MP0003861_abnormal_nervous_system0.37270853
103MP0001764_abnormal_homeostasis0.36921781
104MP0000579_abnormal_nail_morphology0.36727410
105MP0008057_abnormal_DNA_replication0.36210240
106MP0001986_abnormal_taste_sensitivity0.36029170
107MP0005253_abnormal_eye_physiology0.35199281
108MP0004742_abnormal_vestibular_system0.34823399
109MP0005551_abnormal_eye_electrophysiolog0.34481863
110MP0001293_anophthalmia0.34362465
111MP0001727_abnormal_embryo_implantation0.34027733
112MP0003329_amyloid_beta_deposits0.33990307
113MP0005391_vision/eye_phenotype0.33252069
114MP0010307_abnormal_tumor_latency0.32112802
115MP0000462_abnormal_digestive_system0.31949490
116MP0000358_abnormal_cell_content/0.31657402
117MP0001730_embryonic_growth_arrest0.31635756
118MP0001545_abnormal_hematopoietic_system0.31543931
119MP0005397_hematopoietic_system_phenotyp0.31543931
120MP0003315_abnormal_perineum_morphology0.30896644
121MP0001529_abnormal_vocalization0.30365706
122MP0002132_abnormal_respiratory_system0.29395653
123MP0001851_eye_inflammation0.29234876
124MP0009115_abnormal_fat_cell0.29169767
125MP0001849_ear_inflammation0.28992504
126MP0006072_abnormal_retinal_apoptosis0.28950986
127MP0005423_abnormal_somatic_nervous0.27904341
128MP0002084_abnormal_developmental_patter0.27376188
129MP0002249_abnormal_larynx_morphology0.26855673
130MP0002971_abnormal_brown_adipose0.26106470
131MP0002152_abnormal_brain_morphology0.25720977
132MP0002295_abnormal_pulmonary_circulatio0.25706454
133MP0004270_analgesia0.24649432
134MP0002092_abnormal_eye_morphology0.23843321
135MP0002269_muscular_atrophy0.23507033
136MP0008932_abnormal_embryonic_tissue0.23378272
137MP0001919_abnormal_reproductive_system0.22969563
138MP0003936_abnormal_reproductive_system0.21075447
139MP0002085_abnormal_embryonic_tissue0.21041530
140MP0002169_no_abnormal_phenotype0.21012784
141MP0002873_normal_phenotype0.20757460
142MP0004133_heterotaxia0.19673770
143MP0001502_abnormal_circadian_rhythm0.19550523
144MP0004957_abnormal_blastocyst_morpholog0.18320299
145MP0005380_embryogenesis_phenotype0.18224047
146MP0001672_abnormal_embryogenesis/_devel0.18224047
147MP0000313_abnormal_cell_death0.17760879

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.53433457
2Abnormal respiratory motile cilium morphology (HP:0005938)8.97346388
3Abnormal respiratory epithelium morphology (HP:0012253)8.97346388
4Rhinitis (HP:0012384)7.82316563
5Abnormal ciliary motility (HP:0012262)7.57432821
6Chronic bronchitis (HP:0004469)7.36517140
7Severe visual impairment (HP:0001141)7.21328794
8Infertility (HP:0000789)7.06411333
9Nasal polyposis (HP:0100582)6.21225297
10Male infertility (HP:0003251)5.16882297
11Abnormality of the nasal mucosa (HP:0000433)5.05019904
12Bronchiectasis (HP:0002110)4.79991512
13Bronchitis (HP:0012387)4.58998400
14Nephronophthisis (HP:0000090)4.34046871
15Abnormality of macular pigmentation (HP:0008002)4.26836400
16Attenuation of retinal blood vessels (HP:0007843)3.98990141
17Asymmetric septal hypertrophy (HP:0001670)3.91477488
18Abnormal rod and cone electroretinograms (HP:0008323)3.52178955
19Aplasia/Hypoplasia of the earlobes (HP:0009906)3.45565417
20Upper limb muscle weakness (HP:0003484)3.45456228
21Abnormal spermatogenesis (HP:0008669)3.45150952
22Abnormality of the renal medulla (HP:0100957)3.35726767
23Recurrent otitis media (HP:0000403)3.32760707
24Generalized aminoaciduria (HP:0002909)3.23046371
25Insulin-resistant diabetes mellitus (HP:0000831)3.22149914
26Bony spicule pigmentary retinopathy (HP:0007737)3.18658914
27Recurrent sinusitis (HP:0011108)3.10429502
28Hyperkalemia (HP:0002153)3.05687395
29Hyperthyroidism (HP:0000836)3.03120631
30Impulsivity (HP:0100710)2.98120248
31Truncus arteriosus (HP:0001660)2.97102996
32Unilateral renal agenesis (HP:0000122)2.96437700
33Abnormality of dental color (HP:0011073)2.89245290
34Sensory axonal neuropathy (HP:0003390)2.83554051
35Tubulointerstitial nephritis (HP:0001970)2.82663370
36Bradycardia (HP:0001662)2.81929420
37Hypoalphalipoproteinemia (HP:0003233)2.80195982
38Abnormality of midbrain morphology (HP:0002418)2.78215625
39Molar tooth sign on MRI (HP:0002419)2.78215625
40Potter facies (HP:0002009)2.77181277
41Facial shape deformation (HP:0011334)2.77181277
42Recurrent bronchitis (HP:0002837)2.73985906
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.70807680
44Resting tremor (HP:0002322)2.69731149
45Hypoglycemic seizures (HP:0002173)2.68745083
46Atelectasis (HP:0100750)2.65648463
47Metaphyseal dysplasia (HP:0100255)2.63197306
48Cholelithiasis (HP:0001081)2.51569946
49Gonadotropin excess (HP:0000837)2.50491001
50Tubular atrophy (HP:0000092)2.49189189
51Hypoparathyroidism (HP:0000829)2.46706819
52Hypoglycemic coma (HP:0001325)2.45570257
53Reticulocytosis (HP:0001923)2.44088873
54Tubulointerstitial abnormality (HP:0001969)2.43537506
55Cholecystitis (HP:0001082)2.40682320
56Abnormal gallbladder physiology (HP:0012438)2.40682320
57Renal Fanconi syndrome (HP:0001994)2.37890274
58Medial flaring of the eyebrow (HP:0010747)2.37676853
59Abnormal gallbladder morphology (HP:0012437)2.31054885
60Seborrheic dermatitis (HP:0001051)2.30941335
61Progressive sensorineural hearing impairment (HP:0000408)2.27639284
62Postural instability (HP:0002172)2.26582131
63Hypoplastic left heart (HP:0004383)2.25269847
64Azoospermia (HP:0000027)2.24161037
65Chronic hepatic failure (HP:0100626)2.23859605
66Cone-rod dystrophy (HP:0000548)2.19711460
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13609449
68Progressive hearing impairment (HP:0001730)2.12865381
69Insulin resistance (HP:0000855)2.11627299
70Bowel incontinence (HP:0002607)2.11551183
71Postaxial foot polydactyly (HP:0001830)2.07827501
72Abnormal large intestine physiology (HP:0012700)2.06832985
73Poikilocytosis (HP:0004447)2.05870476
74Hand muscle atrophy (HP:0009130)2.05187208
75Abnormality of the heme biosynthetic pathway (HP:0010472)2.01028812
76Entropion (HP:0000621)2.00538661
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3543814
78Dynein arm defect of respiratory motile cilia (HP:0012255)12.6335717
79Absent/shortened dynein arms (HP:0200106)12.6335717
80Menstrual irregularities (HP:0000858)1.98897199
81Abnormality of lateral ventricle (HP:0030047)1.98881560
82Tubulointerstitial fibrosis (HP:0005576)1.96744355
83Myoglobinuria (HP:0002913)1.92720566
84Decreased central vision (HP:0007663)1.89661701
85Hypoplasia of the thymus (HP:0000778)1.89435917
86Respiratory distress (HP:0002098)1.87524559
87Dyschromatopsia (HP:0007641)1.87209963
88Congenital hepatic fibrosis (HP:0002612)1.85249378
89Spastic tetraparesis (HP:0001285)1.84738106
90Stage 5 chronic kidney disease (HP:0003774)1.84314138
91Heterotopia (HP:0002282)1.82807434
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81625919
93Long foot (HP:0001833)1.80333768
94Hypoplastic heart (HP:0001961)1.79907479
95Enlarged epiphyses (HP:0010580)1.79435100
96Hyperinsulinemic hypoglycemia (HP:0000825)1.77308166
97Hypoplastic ischia (HP:0003175)1.76698382
98Abnormality of the costochondral junction (HP:0000919)1.74801630
99Abnormal biliary tract physiology (HP:0012439)1.74089002
100Bile duct proliferation (HP:0001408)1.74089002
101Hyponatremia (HP:0002902)1.72243936
102Taurodontia (HP:0000679)1.70612796
103Abnormality of permanent molar morphology (HP:0011071)1.70612796
104Abnormality of the dental root (HP:0006486)1.70612796
105Spastic paraparesis (HP:0002313)1.69619024
106Horizontal nystagmus (HP:0000666)1.69617378
107Ventricular tachycardia (HP:0004756)1.67797806
108Short ribs (HP:0000773)1.67423595
109Bulbous nose (HP:0000414)1.67305748
110Oculomotor apraxia (HP:0000657)1.66162462
111Abnormality of the aortic arch (HP:0012303)1.66015926
112Small intestinal stenosis (HP:0012848)1.65390215
113Duodenal stenosis (HP:0100867)1.65390215
114Peripheral hypomyelination (HP:0007182)1.65230156
115Abnormality of the renal cortex (HP:0011035)1.64719892
116Choroideremia (HP:0001139)1.64294115
117Convex nasal ridge (HP:0000444)1.63926339
118Abnormality of the gallbladder (HP:0005264)1.63547049
119Pancreatic fibrosis (HP:0100732)1.63058157
120Delusions (HP:0000746)1.62602296
121Abnormality of renal resorption (HP:0011038)1.62052257
122Neoplasm of the heart (HP:0100544)1.61467243
123Fibular hypoplasia (HP:0003038)1.61369071
124Renal dysplasia (HP:0000110)1.61190835
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.60948028
126Polydipsia (HP:0001959)1.60618970
127Abnormal drinking behavior (HP:0030082)1.60618970
128Postaxial hand polydactyly (HP:0001162)1.59663553
129Abnormality of molar (HP:0011077)1.57807448
130Abnormality of molar morphology (HP:0011070)1.57807448
131Cystic liver disease (HP:0006706)1.57342012
132Abnormality of the dental pulp (HP:0006479)1.56269660
133Aplasia/Hypoplasia of the lens (HP:0008063)1.54250323
134Facial cleft (HP:0002006)1.52962802
135Abnormality of dentin (HP:0010299)1.52210083
136True hermaphroditism (HP:0010459)1.51172270
137Supernumerary spleens (HP:0009799)1.48866460
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.45147412
139Absent epiphyses (HP:0010577)1.45147412
140Abnormality of the lower motor neuron (HP:0002366)1.44794933
141Abnormality of renal excretion (HP:0011036)1.44270088
142Median cleft lip (HP:0000161)1.43244646
143Bell-shaped thorax (HP:0001591)1.42085652
144Microglossia (HP:0000171)1.41430361
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.38894623
146Hemorrhage of the eye (HP:0011885)1.38094755
147Amyotrophic lateral sclerosis (HP:0007354)1.36327177
148Short thorax (HP:0010306)1.35654559
149Congenital primary aphakia (HP:0007707)1.35599408
150Gait imbalance (HP:0002141)1.35414967
151Bundle branch block (HP:0011710)1.34114041
152Decreased electroretinogram (ERG) amplitude (HP:0000654)1.34113321
153Deformed sella turcica (HP:0002681)1.33054246
154Impaired proprioception (HP:0010831)1.31761925
155J-shaped sella turcica (HP:0002680)1.30977683
156Chronic sinusitis (HP:0011109)1.27981854
157Neurofibrillary tangles (HP:0002185)1.26650489
158Short femoral neck (HP:0100864)1.25978844
159Fatigable weakness (HP:0003473)1.22362383
160Abnormality of the neuromuscular junction (HP:0003398)1.22362383
161Abnormal urine output (HP:0012590)1.20382147
162Double outlet right ventricle (HP:0001719)1.20317940
163Congenital malformation of the right heart (HP:0011723)1.20317940
164Easy fatigability (HP:0003388)1.18763023
165Sloping forehead (HP:0000340)1.18538790
166Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.17963476
167Pancreatic cysts (HP:0001737)1.17670115
168Absent frontal sinuses (HP:0002688)1.17309407
169Hemiparesis (HP:0001269)1.16577559
170Nephropathy (HP:0000112)1.14884988
171Short nail (HP:0001799)1.14573023
172Nephrogenic diabetes insipidus (HP:0009806)1.14243654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.66038698
2PDK37.66038698
3TESK15.96946147
4PRKD35.78614882
5MAP4K24.99426875
6PDK24.92740554
7ICK4.16815623
8BRD43.04311402
9DDR23.00823781
10PLK22.73887845
11INSRR2.70970186
12EIF2AK12.42966123
13CDK122.22054721
14PNCK2.21622195
15MAP3K22.21438591
16PBK2.10210991
17WNK42.04800425
18PTK2B2.00254441
19STK381.98645021
20MST1R1.96011368
21STK391.92109073
22NEK21.88468255
23MST41.74537672
24MAPK151.48186042
25DYRK1B1.44866176
26MUSK1.42128694
27EEF2K1.40941578
28TTK1.26217654
29MAP3K31.25960802
30CDK71.14685533
31DYRK31.11648909
32PDK11.09196715
33PIK3CG1.07399267
34AKT31.01637749
35STK30.96559144
36ARAF0.95078956
37BCKDK0.94688236
38STK38L0.93289286
39MET0.87784836
40CHEK20.85737097
41PLK40.85554285
42PIM20.85541743
43TYRO30.83831947
44PRKG20.79484048
45VRK10.76354303
46EPHB10.74488396
47PINK10.72878666
48NTRK20.72124000
49BRAF0.71436981
50CCNB10.71365282
51WNK10.70791318
52GRK70.68934133
53MAPKAPK50.67036396
54IRAK10.64977238
55PDPK10.62490175
56VRK20.61372419
57PASK0.56403527
58CDC70.52959872
59MAP3K60.50955913
60FRK0.50624812
61CAMK1G0.49242907
62LATS10.48678394
63SRPK10.48604146
64EPHA20.47397870
65ABL20.47070597
66PAK10.46223196
67LIMK10.45731806
68CSNK1G30.45381978
69CDK80.45036027
70CHEK10.44955012
71MAP3K120.44791406
72SCYL20.44692652
73CSNK1A1L0.44003563
74PLK10.43186208
75LMTK20.42212957
76STK100.41057924
77PLK30.40909717
78MAPKAPK30.40460153
79MYLK0.40279417
80NTRK30.40251920
81STK160.38952434
82MAP2K60.38418668
83LATS20.37409112
84WEE10.37253365
85MAP3K110.36648163
86PRKAA10.36242551
87RIPK40.35152437
88TESK20.35067406
89ATM0.34792057
90ERBB40.34533917
91MARK20.33598306
92ROCK10.32960691
93TRIM280.31455673
94CDK30.30959296
95BMPR1B0.30196153
96PAK20.28648098
97CLK10.28285336
98TAOK10.27881702
99ATR0.27705919
100NEK60.27416945
101IRAK20.26160744
102PAK60.26157652
103MTOR0.23392714
104MAPK100.23188380
105CASK0.22361329
106RPS6KA20.22342165
107PRKCG0.21919951
108MAPK10.21495047
109RAF10.20437332
110AURKA0.20329576
111MAPK140.20299374
112TAOK30.20002391
113MAPK80.19966612
114CAMK10.19624670
115MAP3K40.19615810
116MAP3K90.19172804
117TAOK20.18663900
118CAMK40.17688159
119BRSK20.17130726
120NME20.16704181
121BUB10.15746259
122CAMKK10.14389430
123MAP2K70.14031983
124CDK90.13340878
125STK110.10923018
126RPS6KA10.09450294
127CAMK2A0.08505853
128BRSK10.07801817
129AURKB0.07801594
130GRK10.07660776
131RPS6KB10.07632573
132CDK10.07393186
133PRKCZ0.07329014
134CDK150.07299824
135DYRK20.06922402
136CSNK1D0.06852411
137GSK3B0.06817464
138PRKCQ0.06718237
139PRKAA20.05961406
140MOS0.05827140
141CDK20.04751645
142CDK180.04512672
143CSNK2A10.04387227
144MAP3K10.03804021
145CDK40.03378172
146CDK11A0.03101197
147PRKG10.02467245
148MAP3K50.01919226
149MAP3K80.01318773
150MELK0.01057582
151PRKD20.00770865
152KSR2-0.0183105
153RPS6KA4-0.0130325
154PAK4-0.0006411

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.31824968
2Vitamin B6 metabolism_Homo sapiens_hsa007504.33453494
3Fatty acid biosynthesis_Homo sapiens_hsa000614.16029074
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.03978974
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.60125130
6Linoleic acid metabolism_Homo sapiens_hsa005913.51288902
7Proteasome_Homo sapiens_hsa030503.42900023
8Basal transcription factors_Homo sapiens_hsa030223.11852731
9Pyruvate metabolism_Homo sapiens_hsa006203.04012698
10Dorso-ventral axis formation_Homo sapiens_hsa043202.47733257
11Glucagon signaling pathway_Homo sapiens_hsa049222.40214940
12Butanoate metabolism_Homo sapiens_hsa006502.18557727
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17418036
14Fanconi anemia pathway_Homo sapiens_hsa034602.12802626
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.12438414
16Oocyte meiosis_Homo sapiens_hsa041142.10560683
17Propanoate metabolism_Homo sapiens_hsa006402.07493784
18Ether lipid metabolism_Homo sapiens_hsa005652.02770783
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01624937
20Mismatch repair_Homo sapiens_hsa034301.99662058
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91415106
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.90333576
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89198343
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88991936
25Fatty acid elongation_Homo sapiens_hsa000621.86719443
26Glycerolipid metabolism_Homo sapiens_hsa005611.80790371
27Selenocompound metabolism_Homo sapiens_hsa004501.74284324
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.72477316
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.67201424
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55890630
31PPAR signaling pathway_Homo sapiens_hsa033201.52698146
32Amphetamine addiction_Homo sapiens_hsa050311.51863327
33Nucleotide excision repair_Homo sapiens_hsa034201.49998032
34DNA replication_Homo sapiens_hsa030301.47932243
35Pentose phosphate pathway_Homo sapiens_hsa000301.44627278
36Arginine biosynthesis_Homo sapiens_hsa002201.40494898
37Oxidative phosphorylation_Homo sapiens_hsa001901.35498717
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34395657
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33183433
40RNA transport_Homo sapiens_hsa030131.32093838
41Purine metabolism_Homo sapiens_hsa002301.31263008
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.30947158
43Fructose and mannose metabolism_Homo sapiens_hsa000511.29509152
44Mineral absorption_Homo sapiens_hsa049781.27867601
45Huntingtons disease_Homo sapiens_hsa050161.20794851
46mRNA surveillance pathway_Homo sapiens_hsa030151.20342553
47Folate biosynthesis_Homo sapiens_hsa007901.19708983
48Phenylalanine metabolism_Homo sapiens_hsa003601.18480357
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.18288664
50Arachidonic acid metabolism_Homo sapiens_hsa005901.15158774
51Arginine and proline metabolism_Homo sapiens_hsa003301.14908528
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12131172
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.09826793
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07103815
55Fat digestion and absorption_Homo sapiens_hsa049751.06213003
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06157502
57Hedgehog signaling pathway_Homo sapiens_hsa043401.02781648
58Renin secretion_Homo sapiens_hsa049241.01091596
59Peroxisome_Homo sapiens_hsa041461.00078433
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99822337
61Antigen processing and presentation_Homo sapiens_hsa046120.99356342
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99192537
63Cardiac muscle contraction_Homo sapiens_hsa042600.98282479
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95976732
65Parkinsons disease_Homo sapiens_hsa050120.94306411
66RNA degradation_Homo sapiens_hsa030180.92831667
67Fatty acid degradation_Homo sapiens_hsa000710.90432609
68Type II diabetes mellitus_Homo sapiens_hsa049300.88541564
69Tyrosine metabolism_Homo sapiens_hsa003500.87215529
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86097506
71Fatty acid metabolism_Homo sapiens_hsa012120.86050443
72Estrogen signaling pathway_Homo sapiens_hsa049150.83191893
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82831992
74Cell cycle_Homo sapiens_hsa041100.81335918
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80606021
76RNA polymerase_Homo sapiens_hsa030200.79672980
77One carbon pool by folate_Homo sapiens_hsa006700.78443994
78N-Glycan biosynthesis_Homo sapiens_hsa005100.77029332
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75880900
80Glutathione metabolism_Homo sapiens_hsa004800.75276115
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75140547
82Carbon metabolism_Homo sapiens_hsa012000.75067571
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74503958
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73664030
85Spliceosome_Homo sapiens_hsa030400.73233675
86Insulin secretion_Homo sapiens_hsa049110.70043461
87Sulfur relay system_Homo sapiens_hsa041220.68458651
88Ovarian steroidogenesis_Homo sapiens_hsa049130.67813220
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66831975
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65849194
91Pyrimidine metabolism_Homo sapiens_hsa002400.64108327
92Long-term potentiation_Homo sapiens_hsa047200.61982443
93Homologous recombination_Homo sapiens_hsa034400.59993832
94Alzheimers disease_Homo sapiens_hsa050100.59933431
95Chemical carcinogenesis_Homo sapiens_hsa052040.57477901
96Thyroid hormone synthesis_Homo sapiens_hsa049180.55762184
97Collecting duct acid secretion_Homo sapiens_hsa049660.55350364
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.53946044
99Galactose metabolism_Homo sapiens_hsa000520.53713783
100Inositol phosphate metabolism_Homo sapiens_hsa005620.51752318
101Calcium signaling pathway_Homo sapiens_hsa040200.50300810
102VEGF signaling pathway_Homo sapiens_hsa043700.49904648
103Olfactory transduction_Homo sapiens_hsa047400.49897557
104Nitrogen metabolism_Homo sapiens_hsa009100.49861650
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49345314
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48029636
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47752421
108cAMP signaling pathway_Homo sapiens_hsa040240.46610469
109Vibrio cholerae infection_Homo sapiens_hsa051100.46281490
110Sphingolipid metabolism_Homo sapiens_hsa006000.43986735
111ABC transporters_Homo sapiens_hsa020100.43948201
112AMPK signaling pathway_Homo sapiens_hsa041520.43756716
113Systemic lupus erythematosus_Homo sapiens_hsa053220.43615561
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.43104714
115Bile secretion_Homo sapiens_hsa049760.42530794
116Pancreatic secretion_Homo sapiens_hsa049720.42470243
117Thyroid cancer_Homo sapiens_hsa052160.42342754
118Biosynthesis of amino acids_Homo sapiens_hsa012300.40301663
119Endocytosis_Homo sapiens_hsa041440.38668098
120Viral carcinogenesis_Homo sapiens_hsa052030.37889751
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.37368020
122Salivary secretion_Homo sapiens_hsa049700.37135045
123Cocaine addiction_Homo sapiens_hsa050300.36281366
124Tryptophan metabolism_Homo sapiens_hsa003800.34747473
125Legionellosis_Homo sapiens_hsa051340.34365873
126Protein digestion and absorption_Homo sapiens_hsa049740.32950180
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32669329
128Metabolic pathways_Homo sapiens_hsa011000.30744281
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30061208
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29970162
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29386666
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28014094
133Steroid biosynthesis_Homo sapiens_hsa001000.27799130
134Wnt signaling pathway_Homo sapiens_hsa043100.27667853
135Taste transduction_Homo sapiens_hsa047420.27638350
136Renin-angiotensin system_Homo sapiens_hsa046140.26750565
137Non-homologous end-joining_Homo sapiens_hsa034500.26087292
138Gastric acid secretion_Homo sapiens_hsa049710.25616891
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25275945
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23116446
141Regulation of autophagy_Homo sapiens_hsa041400.21944482
142Basal cell carcinoma_Homo sapiens_hsa052170.21889764
143Alcoholism_Homo sapiens_hsa050340.21690127
144Glutamatergic synapse_Homo sapiens_hsa047240.21516866
145Base excision repair_Homo sapiens_hsa034100.21080286
146Circadian rhythm_Homo sapiens_hsa047100.20169267
147Synaptic vesicle cycle_Homo sapiens_hsa047210.19949213
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17687312
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14915682

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