THEM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of sodium ion transmembrane transporter activity (GO:2000651)6.30942730
2negative regulation of interleukin-1 beta production (GO:0032691)6.27946900
3adult feeding behavior (GO:0008343)5.76081372
4growth hormone secretion (GO:0030252)5.37858196
5negative regulation of interleukin-1 production (GO:0032692)5.33093658
6positive regulation of sodium ion transmembrane transport (GO:1902307)4.48288281
7neuron cell-cell adhesion (GO:0007158)4.43397376
8DNA deamination (GO:0045006)4.34802867
9positive thymic T cell selection (GO:0045059)4.29055646
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18268787
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15658807
12protein import into peroxisome matrix (GO:0016558)4.03429673
13positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.98890912
14ATP synthesis coupled proton transport (GO:0015986)3.94078628
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94078628
16fatty acid elongation (GO:0030497)3.93406766
17auditory receptor cell stereocilium organization (GO:0060088)3.82413990
18water-soluble vitamin biosynthetic process (GO:0042364)3.81753704
19synaptic vesicle exocytosis (GO:0016079)3.80432374
20regulation of interleukin-6 biosynthetic process (GO:0045408)3.80022868
21presynaptic membrane assembly (GO:0097105)3.75161578
22positive T cell selection (GO:0043368)3.73252112
23presynaptic membrane organization (GO:0097090)3.65830425
24protein localization to synapse (GO:0035418)3.61789648
25transcription elongation from RNA polymerase III promoter (GO:0006385)3.58055856
26termination of RNA polymerase III transcription (GO:0006386)3.58055856
27response to food (GO:0032094)3.57058233
28vocalization behavior (GO:0071625)3.51962212
29neuronal action potential propagation (GO:0019227)3.51760157
30chaperone-mediated protein transport (GO:0072321)3.51289346
31pyrimidine nucleobase catabolic process (GO:0006208)3.50847799
32central nervous system myelination (GO:0022010)3.50141437
33axon ensheathment in central nervous system (GO:0032291)3.50141437
34respiratory electron transport chain (GO:0022904)3.48646740
35regulation of response to food (GO:0032095)3.45894534
36respiratory chain complex IV assembly (GO:0008535)3.44821589
37long-chain fatty acid biosynthetic process (GO:0042759)3.41973664
38electron transport chain (GO:0022900)3.41936554
39positive regulation of defense response to virus by host (GO:0002230)3.37872135
40neuron recognition (GO:0008038)3.35732259
41pseudouridine synthesis (GO:0001522)3.33245759
42multicellular organism reproduction (GO:0032504)3.33018008
43regulation of appetite (GO:0032098)3.32597526
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.32274609
45L-phenylalanine catabolic process (GO:0006559)3.32274609
46positive regulation of synapse assembly (GO:0051965)3.31148137
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.28305585
48thymic T cell selection (GO:0045061)3.28241557
49negative regulation of neurotransmitter transport (GO:0051589)3.27500219
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.26083730
51rRNA catabolic process (GO:0016075)3.25321017
52gamma-aminobutyric acid transport (GO:0015812)3.22204679
53one-carbon compound transport (GO:0019755)3.21344443
54adaptation of signaling pathway (GO:0023058)3.17016573
55preassembly of GPI anchor in ER membrane (GO:0016254)3.16517894
56glutamate secretion (GO:0014047)3.14122364
57cerebellar granule cell differentiation (GO:0021707)3.13387733
58negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.12579345
59hindbrain development (GO:0030902)3.09361931
60cytochrome complex assembly (GO:0017004)3.07844005
61glutamate receptor signaling pathway (GO:0007215)3.07635104
62cholesterol biosynthetic process (GO:0006695)3.06537947
63nucleobase catabolic process (GO:0046113)3.05282601
64mannosylation (GO:0097502)3.04381741
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.03968456
66negative regulation of telomere maintenance (GO:0032205)3.03912092
67ATP hydrolysis coupled proton transport (GO:0015991)3.02676888
68energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.02676888
69intracellular protein transmembrane import (GO:0044743)3.02225509
70behavioral response to cocaine (GO:0048148)3.00171185
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98654346
72establishment of mitochondrion localization (GO:0051654)2.98484130
73negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97271768
74nucleotide transmembrane transport (GO:1901679)2.96762688
75neurotransmitter-gated ion channel clustering (GO:0072578)2.96691513
76cellular ketone body metabolic process (GO:0046950)2.95881114
77regulation of memory T cell differentiation (GO:0043380)2.93770575
78negative T cell selection (GO:0043383)2.93678194
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93393069
80L-phenylalanine metabolic process (GO:0006558)2.93393069
81ubiquinone biosynthetic process (GO:0006744)2.92715367
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92311421
83neurotransmitter catabolic process (GO:0042135)2.89007133
84negative thymic T cell selection (GO:0045060)2.87339069
85protein complex biogenesis (GO:0070271)2.87230847
86neurotransmitter secretion (GO:0007269)2.86535173
87indolalkylamine metabolic process (GO:0006586)2.86205588
88regulation of synaptic vesicle exocytosis (GO:2000300)2.85225282
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84499129
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84499129
91protein neddylation (GO:0045116)2.84131507
92cellular response to interleukin-15 (GO:0071350)2.81696610
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81670029
94ribosomal large subunit biogenesis (GO:0042273)2.81167266
95neuron-neuron synaptic transmission (GO:0007270)2.80711260
96mitochondrial respiratory chain complex assembly (GO:0033108)2.80567256
97neurotransmitter uptake (GO:0001504)2.79904434
98regulation of regulatory T cell differentiation (GO:0045589)2.79609228
99T cell selection (GO:0045058)2.77868282
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77671008
101mitochondrial respiratory chain complex I assembly (GO:0032981)2.77671008
102NADH dehydrogenase complex assembly (GO:0010257)2.77671008
103regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76801862
104platelet dense granule organization (GO:0060155)2.76049994
105regulation of glutamate receptor signaling pathway (GO:1900449)2.74993635
106regulation of glutamate secretion (GO:0014048)2.74747448
107axonal fasciculation (GO:0007413)2.73808076
108neurotransmitter transport (GO:0006836)2.73595971
109protein localization to peroxisome (GO:0072662)2.72960478
110protein targeting to peroxisome (GO:0006625)2.72960478
111establishment of protein localization to peroxisome (GO:0072663)2.72960478
112sterol biosynthetic process (GO:0016126)2.70956542
113viral transcription (GO:0019083)2.70622304
114synaptic transmission, glutamatergic (GO:0035249)2.70608206
115transmission of nerve impulse (GO:0019226)2.70555812
116ribosomal small subunit assembly (GO:0000028)2.70415859
117substantia nigra development (GO:0021762)2.70238829
118regulation of T cell mediated cytotoxicity (GO:0001914)2.69923248
119translational termination (GO:0006415)2.69681591
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69267411
121maturation of 5.8S rRNA (GO:0000460)2.68581576
122regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68573149
123gamma-aminobutyric acid signaling pathway (GO:0007214)2.68306239
124organelle membrane fusion (GO:0090174)2.68085526
125neuron remodeling (GO:0016322)2.67558224
126regulation of defense response to virus by host (GO:0050691)2.66747176
127postsynaptic membrane organization (GO:0001941)2.65849107
128NAD biosynthetic process (GO:0009435)2.65684810
129positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65265713
130calcium-mediated signaling using intracellular calcium source (GO:0035584)2.65017510
131inner ear receptor stereocilium organization (GO:0060122)2.64329751
132coenzyme catabolic process (GO:0009109)2.64307320
133detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.63850277
134detection of temperature stimulus involved in sensory perception (GO:0050961)2.63850277
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61741546
136rRNA modification (GO:0000154)2.60393884
137tRNA processing (GO:0008033)2.60101190
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59350551
139dendritic spine morphogenesis (GO:0060997)2.58959966
140ketone body metabolic process (GO:1902224)2.58712061
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58136031
142hydrogen ion transmembrane transport (GO:1902600)2.58039039
143establishment of protein localization to mitochondrial membrane (GO:0090151)2.57306767
144positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57207407
145negative regulation of neurotransmitter secretion (GO:0046929)2.56376362
146cellular response to interferon-beta (GO:0035458)2.55880145
147regulation of neurotransmitter levels (GO:0001505)2.55851296
148positive regulation of gluconeogenesis (GO:0045722)2.55212387
149positive regulation of T cell differentiation in thymus (GO:0033089)2.54623805
150epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.54331807
151regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54224993
152urate metabolic process (GO:0046415)2.54153935
153startle response (GO:0001964)2.53321627
154negative regulation of dendrite morphogenesis (GO:0050774)2.52724522
155negative regulation of microtubule polymerization (GO:0031115)2.52590546
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.50677907
157ATP biosynthetic process (GO:0006754)2.50379960
158negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49703596
159aromatic amino acid family catabolic process (GO:0009074)2.49633904
160metallo-sulfur cluster assembly (GO:0031163)2.49175686
161iron-sulfur cluster assembly (GO:0016226)2.49175686
162regulation of synaptic transmission, glutamatergic (GO:0051966)2.49171598
163regulation of synapse assembly (GO:0051963)2.49117327
164piRNA metabolic process (GO:0034587)2.47334880
165ubiquinone metabolic process (GO:0006743)2.46846686
166tRNA modification (GO:0006400)2.46563034
167cytidine metabolic process (GO:0046087)2.46335932
168cytidine catabolic process (GO:0006216)2.46335932
169cytidine deamination (GO:0009972)2.46335932
170GMP metabolic process (GO:0046037)2.46019700
171behavioral response to nicotine (GO:0035095)2.45870778
172cell migration in hindbrain (GO:0021535)2.44022680
173L-methionine salvage (GO:0071267)2.43987675
174L-methionine biosynthetic process (GO:0071265)2.43987675
175amino acid salvage (GO:0043102)2.43987675
176regulation of excitatory postsynaptic membrane potential (GO:0060079)2.42976114
177exploration behavior (GO:0035640)2.42376515
178autophagic vacuole fusion (GO:0000046)2.41843493
179translational elongation (GO:0006414)2.41672875
180axoneme assembly (GO:0035082)2.40859254
181fear response (GO:0042596)2.40610073
182regulation of synaptic vesicle transport (GO:1902803)2.40604059
183synapse assembly (GO:0007416)2.40581661
184negative regulation of T cell differentiation in thymus (GO:0033085)2.40374322
185regulation of postsynaptic membrane potential (GO:0060078)2.39158205
186peroxisome fission (GO:0016559)2.38782697
187purine nucleoside triphosphate biosynthetic process (GO:0009145)2.37033454
188proton transport (GO:0015992)2.36774707
189purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.35798865
190regulation of neuronal synaptic plasticity (GO:0048168)2.35705477
191negative regulation of dendrite development (GO:2000171)2.35311286
192dopamine biosynthetic process (GO:0042416)2.35255757
193regulation of long-term neuronal synaptic plasticity (GO:0048169)2.35195299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.79051548
2EZH2_22144423_ChIP-Seq_EOC_Human4.65550444
3GBX2_23144817_ChIP-Seq_PC3_Human3.53275692
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.51555365
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.49834312
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.27482989
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12264622
8* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95229310
9TAF15_26573619_Chip-Seq_HEK293_Human2.93522539
10VDR_23849224_ChIP-Seq_CD4+_Human2.85162129
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78823610
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66245880
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.61812079
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55287863
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52208102
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.46766845
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41328748
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.39441545
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.24925138
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24446303
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21414930
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21198205
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19110025
24* FOXP3_21729870_ChIP-Seq_TREG_Human2.18529973
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18011976
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13003022
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12930290
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.10967980
29VDR_22108803_ChIP-Seq_LS180_Human2.10408107
30REST_21632747_ChIP-Seq_MESCs_Mouse2.09507916
31RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09336760
32EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09336760
33CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08236794
34JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07316786
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07240793
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04485905
37MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02064137
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01161172
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90010602
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89858530
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87425246
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.85904071
43* GATA3_26560356_Chip-Seq_TH2_Human1.85841119
44IRF1_19129219_ChIP-ChIP_H3396_Human1.83531423
45P300_19829295_ChIP-Seq_ESCs_Human1.83112132
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80505877
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77880856
48MYC_18940864_ChIP-ChIP_HL60_Human1.77396614
49TP53_22573176_ChIP-Seq_HFKS_Human1.77243626
50* AR_21572438_ChIP-Seq_LNCaP_Human1.74207844
51ELK1_19687146_ChIP-ChIP_HELA_Human1.74051451
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.73407483
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72994333
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69752726
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.64385994
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63834825
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.63225085
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61529242
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57278051
60SMAD4_21799915_ChIP-Seq_A2780_Human1.55786685
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54735296
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.54480082
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54329991
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50677831
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.50328133
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50011039
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48607678
68ZNF274_21170338_ChIP-Seq_K562_Hela1.48595905
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47627640
70FUS_26573619_Chip-Seq_HEK293_Human1.47108063
71IGF1R_20145208_ChIP-Seq_DFB_Human1.45744237
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45325965
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44610269
74RNF2_27304074_Chip-Seq_NSC_Mouse1.44483970
75ER_23166858_ChIP-Seq_MCF-7_Human1.44359452
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.41667374
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41236318
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39310052
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38423847
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36426276
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35944397
82* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35342302
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34727758
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.34204933
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33607634
86EWS_26573619_Chip-Seq_HEK293_Human1.33298392
87MYB_26560356_Chip-Seq_TH2_Human1.31912789
88* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31064409
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.30946166
90* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30769116
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29229482
92* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28845915
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26684331
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25846340
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25502795
96* GABP_19822575_ChIP-Seq_HepG2_Human1.24964349
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.23492207
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23492207
99HTT_18923047_ChIP-ChIP_STHdh_Human1.23153937
100AR_20517297_ChIP-Seq_VCAP_Human1.21667204
101* AR_25329375_ChIP-Seq_VCAP_Human1.21572216
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21548628
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20565369
104KDM5A_27292631_Chip-Seq_BREAST_Human1.19227174
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18629447
106EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17541257
107DCP1A_22483619_ChIP-Seq_HELA_Human1.16837321
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16821497
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16709117
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15911831
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.14675162
112ERA_21632823_ChIP-Seq_H3396_Human1.14438729
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14098659
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13456180
115NANOG_20526341_ChIP-Seq_ESCs_Human1.13434400
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12180144
117RUNX2_22187159_ChIP-Seq_PCA_Human1.11629426
118JUN_21703547_ChIP-Seq_K562_Human1.11369560
119GATA3_21878914_ChIP-Seq_MCF-7_Human1.09087405
120FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08852496
121MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08193422
122SOX2_21211035_ChIP-Seq_LN229_Gbm1.08128682
123RARB_27405468_Chip-Seq_BRAIN_Mouse1.07668215
124* GATA3_27048872_Chip-Seq_THYMUS_Human1.07542081
125HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07519788
126STAT3_23295773_ChIP-Seq_U87_Human1.07391046
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07134528
128DROSHA_22980978_ChIP-Seq_HELA_Human1.07098470
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06765100
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06515566
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05953373
132IRF8_21731497_ChIP-ChIP_J774_Mouse1.05777555
133BCAT_22108803_ChIP-Seq_LS180_Human1.05620191
134P53_21459846_ChIP-Seq_SAOS-2_Human1.05581876
135IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05206536
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05149126
137RUNX_20019798_ChIP-Seq_JUKART_Human1.05025719
138MYC_19829295_ChIP-Seq_ESCs_Human1.04964323
139* TTF2_22483619_ChIP-Seq_HELA_Human1.04940937
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.04265396
141HOXB7_26014856_ChIP-Seq_BT474_Human1.04221946
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03985791
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03773298
144MYC_18555785_ChIP-Seq_MESCs_Mouse1.03684706
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03427249
146SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02350652
147CIITA_25753668_ChIP-Seq_RAJI_Human1.02142324
148SOX2_19829295_ChIP-Seq_ESCs_Human1.01957672
149NANOG_19829295_ChIP-Seq_ESCs_Human1.01957672
150KDM2B_26808549_Chip-Seq_REH_Human1.01738646
151NCOR_22424771_ChIP-Seq_293T_Human1.00879170
152ERG_21242973_ChIP-ChIP_JURKAT_Human0.98932888
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98904885
154YY1_21170310_ChIP-Seq_MESCs_Mouse0.97968917
155TAL1_26923725_Chip-Seq_HPCs_Mouse0.97824380
156P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97770800
157ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97671705
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97130541
159CMYC_18555785_Chip-Seq_ESCs_Mouse0.97011036
160EZH2_27294783_Chip-Seq_NPCs_Mouse0.96962253
161MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96830732
162TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96720799
163GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96707062
164MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96457739
165TP53_18474530_ChIP-ChIP_U2OS_Human0.96140399
166P53_22387025_ChIP-Seq_ESCs_Mouse0.96095254
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96059555
168NFE2_27457419_Chip-Seq_LIVER_Mouse0.95836749
169RAC3_21632823_ChIP-Seq_H3396_Human0.95596179
170* P300_27268052_Chip-Seq_Bcells_Human0.95497218
171TP63_19390658_ChIP-ChIP_HaCaT_Human0.95479825
172TAF2_19829295_ChIP-Seq_ESCs_Human0.95303200
173SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94863993
174EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94831786
175E2F1_18555785_Chip-Seq_ESCs_Mouse0.94825084
176CBP_20019798_ChIP-Seq_JUKART_Human0.94539021
177IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94539021
178TCF4_23295773_ChIP-Seq_U87_Human0.94020074
179RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93972918
180FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93373035
181PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92326956
182* GATA6_21074721_ChIP-Seq_CACO-2_Human0.91732937
183BCL6_27268052_Chip-Seq_Bcells_Human0.91352908
184PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91174382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.40929656
2MP0004270_analgesia3.31189613
3MP0004859_abnormal_synaptic_plasticity3.19875361
4MP0006276_abnormal_autonomic_nervous2.88155324
5MP0003635_abnormal_synaptic_transmissio2.84970142
6MP0001968_abnormal_touch/_nociception2.82423852
7MP0005423_abnormal_somatic_nervous2.72817773
8MP0009745_abnormal_behavioral_response2.72802905
9MP0009046_muscle_twitch2.65466670
10MP0002064_seizures2.61960973
11MP0008877_abnormal_DNA_methylation2.54721995
12MP0005220_abnormal_exocrine_pancreas2.52396983
13MP0002735_abnormal_chemical_nociception2.52340488
14MP0001529_abnormal_vocalization2.46083524
15MP0002734_abnormal_mechanical_nocicepti2.45314173
16MP0002063_abnormal_learning/memory/cond2.43523538
17MP0002736_abnormal_nociception_after2.43212336
18MP0002272_abnormal_nervous_system2.40710279
19MP0002572_abnormal_emotion/affect_behav2.36332189
20MP0005671_abnormal_response_to2.32963820
21MP0001440_abnormal_grooming_behavior2.27721084
22MP0003866_abnormal_defecation2.27296027
23MP0002139_abnormal_hepatobiliary_system2.19461077
24MP0003329_amyloid_beta_deposits2.19167103
25MP0001905_abnormal_dopamine_level2.14324680
26MP0005075_abnormal_melanosome_morpholog2.12272239
27MP0001486_abnormal_startle_reflex2.12086507
28MP0002822_catalepsy2.11865445
29MP0005084_abnormal_gallbladder_morpholo2.10532484
30MP0003646_muscle_fatigue2.01393524
31MP0005360_urolithiasis2.00993809
32MP0002102_abnormal_ear_morphology1.98748719
33MP0004142_abnormal_muscle_tone1.95816177
34MP0003868_abnormal_feces_composition1.89336518
35MP0000778_abnormal_nervous_system1.88984373
36MP0002928_abnormal_bile_duct1.88413317
37MP0002067_abnormal_sensory_capabilities1.87569325
38MP0002733_abnormal_thermal_nociception1.83508869
39MP0004147_increased_porphyrin_level1.81803086
40MP0001919_abnormal_reproductive_system1.81572319
41MP0002160_abnormal_reproductive_system1.79823852
42MP0001970_abnormal_pain_threshold1.77321792
43MP0003763_abnormal_thymus_physiology1.76180725
44MP0008058_abnormal_DNA_repair1.74754608
45MP0000372_irregular_coat_pigmentation1.73110420
46MP0001501_abnormal_sleep_pattern1.72006289
47MP0003172_abnormal_lysosome_physiology1.71596652
48MP0004924_abnormal_behavior1.65928472
49MP0005386_behavior/neurological_phenoty1.65928472
50MP0001984_abnormal_olfaction1.65274109
51MP0002184_abnormal_innervation1.63347500
52MP0002837_dystrophic_cardiac_calcinosis1.61723657
53MP0004742_abnormal_vestibular_system1.60086091
54MP0005389_reproductive_system_phenotype1.59639446
55MP0005085_abnormal_gallbladder_physiolo1.56890023
56MP0003786_premature_aging1.56822355
57MP0008875_abnormal_xenobiotic_pharmacok1.55164729
58MP0000920_abnormal_myelination1.54440764
59MP0001873_stomach_inflammation1.49868010
60MP0002132_abnormal_respiratory_system1.49825145
61MP0005646_abnormal_pituitary_gland1.48155291
62MP0003787_abnormal_imprinting1.47858684
63MP0009278_abnormal_bone_marrow1.46981473
64MP0004858_abnormal_nervous_system1.46409317
65MP0006292_abnormal_olfactory_placode1.45211038
66MP0008995_early_reproductive_senescence1.44780015
67MP0002876_abnormal_thyroid_physiology1.44564668
68MP0002693_abnormal_pancreas_physiology1.43612977
69MP0000015_abnormal_ear_pigmentation1.40592998
70MP0002557_abnormal_social/conspecific_i1.37548500
71MP0001663_abnormal_digestive_system1.31430801
72MP0001835_abnormal_antigen_presentation1.31278888
73MP0003303_peritoneal_inflammation1.30806677
74MP0002138_abnormal_hepatobiliary_system1.30444022
75MP0009379_abnormal_foot_pigmentation1.30355052
76MP0003879_abnormal_hair_cell1.30304607
77MP0005645_abnormal_hypothalamus_physiol1.29058085
78MP0001800_abnormal_humoral_immune1.27384028
79MP0000685_abnormal_immune_system1.26105648
80MP0002066_abnormal_motor_capabilities/c1.24967045
81MP0002638_abnormal_pupillary_reflex1.24092758
82MP0000604_amyloidosis1.23528167
83MP0010386_abnormal_urinary_bladder1.21292427
84MP0002882_abnormal_neuron_morphology1.21011836
85MP0005365_abnormal_bile_salt1.20622604
86MP0003136_yellow_coat_color1.20368980
87MP0005551_abnormal_eye_electrophysiolog1.19689043
88MP0005332_abnormal_amino_acid1.19553366
89MP0002723_abnormal_immune_serum1.17554299
90MP0001188_hyperpigmentation1.17473876
91MP0002653_abnormal_ependyma_morphology1.17466451
92MP0002229_neurodegeneration1.16253851
93MP0003638_abnormal_response/metabolism_1.15588607
94MP0000955_abnormal_spinal_cord1.15418093
95MP0000427_abnormal_hair_cycle1.12998749
96MP0000703_abnormal_thymus_morphology1.12953401
97MP0004130_abnormal_muscle_cell1.12827072
98MP0001986_abnormal_taste_sensitivity1.11655885
99MP0008569_lethality_at_weaning1.11384526
100MP0005410_abnormal_fertilization1.09398309
101MP0009333_abnormal_splenocyte_physiolog1.09098789
102MP0002277_abnormal_respiratory_mucosa1.09054749
103MP0001963_abnormal_hearing_physiology1.08772750
104MP0003690_abnormal_glial_cell1.06177865
105MP0005253_abnormal_eye_physiology1.05747696
106MP0005409_darkened_coat_color1.05330604
107MP0003959_abnormal_lean_body1.04613066
108MP0003634_abnormal_glial_cell1.04139692
109MP0001502_abnormal_circadian_rhythm1.03644919
110MP0003631_nervous_system_phenotype1.03467048
111MP0003806_abnormal_nucleotide_metabolis1.03119447
112MP0003693_abnormal_embryo_hatching1.02717876
113MP0002420_abnormal_adaptive_immunity1.02363337
114MP0002095_abnormal_skin_pigmentation1.02112245
115MP0005535_abnormal_body_temperature1.02022132
116MP0005397_hematopoietic_system_phenotyp1.01541824
117MP0001545_abnormal_hematopoietic_system1.01541824
118MP0001819_abnormal_immune_cell1.01256067
119MP0009697_abnormal_copulation1.00886208
120MP0000470_abnormal_stomach_morphology1.00433934
121MP0005451_abnormal_body_composition0.99933237
122MP0004885_abnormal_endolymph0.98708942
123MP0005083_abnormal_biliary_tract0.98690531
124MP0003633_abnormal_nervous_system0.98397914
125MP0006035_abnormal_mitochondrial_morpho0.97696605
126MP0002148_abnormal_hypersensitivity_rea0.97494137
127MP0003195_calcinosis0.97416746
128MP0002234_abnormal_pharynx_morphology0.96705815
129MP0004381_abnormal_hair_follicle0.96628483
130MP0003632_abnormal_nervous_system0.96423302
131MP0008872_abnormal_physiological_respon0.96071620
132MP0005174_abnormal_tail_pigmentation0.95928272
133MP0002752_abnormal_somatic_nervous0.95654070
134MP0003186_abnormal_redox_activity0.94667738
135MP0002405_respiratory_system_inflammati0.93983865
136MP0004811_abnormal_neuron_physiology0.93485578
137MP0000689_abnormal_spleen_morphology0.93461061
138MP0005000_abnormal_immune_tolerance0.93320708
139MP0003119_abnormal_digestive_system0.92289501
140MP0008961_abnormal_basal_metabolism0.91210456
141MP0002398_abnormal_bone_marrow0.90520718
142MP0009643_abnormal_urine_homeostasis0.90143809
143MP0003122_maternal_imprinting0.90018776
144MP0008260_abnormal_autophagy0.89332896
145MP0001666_abnormal_nutrient_absorption0.88120221
146MP0000716_abnormal_immune_system0.87619486
147MP0002452_abnormal_antigen_presenting0.87326570
148MP0009785_altered_susceptibility_to0.85669045
149MP0000026_abnormal_inner_ear0.84635906
150MP0002069_abnormal_eating/drinking_beha0.84552036
151MP0005448_abnormal_energy_balance0.84075168
152MP0002152_abnormal_brain_morphology0.83472658
153MP0005171_absent_coat_pigmentation0.81627837
154MP0001764_abnormal_homeostasis0.81533119
155MP0003011_delayed_dark_adaptation0.80232751
156MP0000751_myopathy0.79596810
157MP0004145_abnormal_muscle_electrophysio0.77406736
158MP0006036_abnormal_mitochondrial_physio0.77405799
159MP0002722_abnormal_immune_system0.77222179
160MP0001790_abnormal_immune_system0.75503368
161MP0005387_immune_system_phenotype0.75503368
162MP0001485_abnormal_pinna_reflex0.74904090
163MP0004043_abnormal_pH_regulation0.74400830
164MP0000631_abnormal_neuroendocrine_gland0.69791201
165MP0003718_maternal_effect0.68073071
166MP0000538_abnormal_urinary_bladder0.67528307
167MP0010329_abnormal_lipoprotein_level0.66994130
168MP0006072_abnormal_retinal_apoptosis0.66392931
169MP0004215_abnormal_myocardial_fiber0.64839106
170MP0004085_abnormal_heartbeat0.64520670
171MP0001664_abnormal_digestion0.64044142
172MP0008874_decreased_physiological_sensi0.63855211
173MP0005379_endocrine/exocrine_gland_phen0.62032827

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.99075644
2Focal motor seizures (HP:0011153)4.76498682
3Myokymia (HP:0002411)4.18710414
4Acute necrotizing encephalopathy (HP:0006965)3.95836318
5Abnormality of alanine metabolism (HP:0010916)3.93243549
6Hyperalaninemia (HP:0003348)3.93243549
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.93243549
8Birth length less than 3rd percentile (HP:0003561)3.87621009
9Pancreatic cysts (HP:0001737)3.76743457
10Abnormality of glycolysis (HP:0004366)3.66602602
11Increased serum pyruvate (HP:0003542)3.66602602
12Pancreatic fibrosis (HP:0100732)3.65169114
13Gastrointestinal infarctions (HP:0005244)3.64826834
14Abnormal mitochondria in muscle tissue (HP:0008316)3.62654646
15Atonic seizures (HP:0010819)3.59566992
16Hyperventilation (HP:0002883)3.54437368
17Acute encephalopathy (HP:0006846)3.53981851
18Pheochromocytoma (HP:0002666)3.42545748
19Progressive macrocephaly (HP:0004481)3.41896594
20Neuroendocrine neoplasm (HP:0100634)3.35413604
21Cerebellar dysplasia (HP:0007033)3.31377256
22Focal seizures (HP:0007359)3.30413635
23Mitochondrial inheritance (HP:0001427)3.30077962
24Neurofibrillary tangles (HP:0002185)3.29731950
25Congenital stationary night blindness (HP:0007642)3.22721133
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.15194622
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.15194622
28Renal cortical cysts (HP:0000803)3.06734179
29Abnormality of the renal cortex (HP:0011035)2.99944978
30Abnormality of the corticospinal tract (HP:0002492)2.98574824
31Global brain atrophy (HP:0002283)2.98125791
32Absence seizures (HP:0002121)2.94362226
33Abnormality of midbrain morphology (HP:0002418)2.91825368
34Molar tooth sign on MRI (HP:0002419)2.91825368
35Generalized tonic-clonic seizures (HP:0002069)2.88582298
36Epileptic encephalopathy (HP:0200134)2.86778665
37Cerebral edema (HP:0002181)2.86269098
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.82369988
39Cerebral inclusion bodies (HP:0100314)2.81521238
40Abnormal number of erythroid precursors (HP:0012131)2.80526712
41Nephronophthisis (HP:0000090)2.77010532
42Polyphagia (HP:0002591)2.75724807
43Increased CSF lactate (HP:0002490)2.75524838
44Progressive cerebellar ataxia (HP:0002073)2.73537524
45Hepatocellular necrosis (HP:0001404)2.72813735
46True hermaphroditism (HP:0010459)2.71407184
47Renal Fanconi syndrome (HP:0001994)2.70105364
48Dialeptic seizures (HP:0011146)2.67329886
49Abnormal biliary tract physiology (HP:0012439)2.66025694
50Bile duct proliferation (HP:0001408)2.66025694
51Progressive microcephaly (HP:0000253)2.65494049
52Severe combined immunodeficiency (HP:0004430)2.64672662
53Febrile seizures (HP:0002373)2.61331684
54Chorioretinal atrophy (HP:0000533)2.57497972
55Rectal prolapse (HP:0002035)2.53736568
56Abnormality of cells of the erythroid lineage (HP:0012130)2.51634594
57Metaphyseal dysplasia (HP:0100255)2.51331592
58Leukodystrophy (HP:0002415)2.50893588
59Termporal pattern (HP:0011008)2.50429187
60Insidious onset (HP:0003587)2.50429187
61Stomatitis (HP:0010280)2.47652451
62Attenuation of retinal blood vessels (HP:0007843)2.46960295
63Neoplasm of head and neck (HP:0012288)2.46083004
64Esophageal neoplasm (HP:0100751)2.46083004
65Elevated erythrocyte sedimentation rate (HP:0003565)2.45008534
66Increased hepatocellular lipid droplets (HP:0006565)2.44688067
67Abolished electroretinogram (ERG) (HP:0000550)2.44469493
68Chronic hepatic failure (HP:0100626)2.41958025
69Encephalitis (HP:0002383)2.41417270
70Optic disc pallor (HP:0000543)2.41055947
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39872799
72Gait imbalance (HP:0002141)2.38694326
73Poor suck (HP:0002033)2.38103997
74Broad-based gait (HP:0002136)2.37039893
75Cerebral hemorrhage (HP:0001342)2.36793807
76Brushfield spots (HP:0001088)2.36068892
77Spastic gait (HP:0002064)2.35211801
78Hypothermia (HP:0002045)2.35154545
79Tubular atrophy (HP:0000092)2.34188453
80X-linked dominant inheritance (HP:0001423)2.30956918
81Visual hallucinations (HP:0002367)2.29880742
82Sensory axonal neuropathy (HP:0003390)2.29484645
83Gonadal dysgenesis (HP:0000133)2.29394632
84Brittle hair (HP:0002299)2.27448749
85Microretrognathia (HP:0000308)2.26795778
86Pendular nystagmus (HP:0012043)2.25219762
87Nasal polyposis (HP:0100582)2.25192031
88Disproportionate short-trunk short stature (HP:0003521)2.23767343
89Retinal dysplasia (HP:0007973)2.22687865
90Abnormality of the renal medulla (HP:0100957)2.22570058
91Clumsiness (HP:0002312)2.22175550
92Lipid accumulation in hepatocytes (HP:0006561)2.21868234
93Hypochromic anemia (HP:0001931)2.20274002
94Absent/shortened dynein arms (HP:0200106)2.20104955
95Dynein arm defect of respiratory motile cilia (HP:0012255)2.20104955
96Hepatic necrosis (HP:0002605)2.19940459
97Progressive inability to walk (HP:0002505)2.19456463
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18319258
99Dysmetria (HP:0001310)2.18068271
100Medial flaring of the eyebrow (HP:0010747)2.18026781
101Delusions (HP:0000746)2.15881026
102Prolonged partial thromboplastin time (HP:0003645)2.15877868
103Parakeratosis (HP:0001036)2.15122149
1043-Methylglutaconic aciduria (HP:0003535)2.15102161
105Ketosis (HP:0001946)2.14026706
106Abnormal eating behavior (HP:0100738)2.13127775
107IgG deficiency (HP:0004315)2.12835585
108Ketoacidosis (HP:0001993)2.11878862
109Scanning speech (HP:0002168)2.10709576
110Spastic paraparesis (HP:0002313)2.09980939
111Generalized aminoaciduria (HP:0002909)2.09022759
112Increased serum lactate (HP:0002151)2.06597812
113Anxiety (HP:0000739)2.05279087
114Limb dystonia (HP:0002451)2.05147519
115Cystic liver disease (HP:0006706)2.04833473
116Action tremor (HP:0002345)2.02905006
117Aplastic anemia (HP:0001915)2.02690187
118Abnormal ciliary motility (HP:0012262)2.02473554
119Humeroradial synostosis (HP:0003041)2.02239498
120Synostosis involving the elbow (HP:0003938)2.02239498
121Congenital primary aphakia (HP:0007707)2.01980889
122Hyperglycinemia (HP:0002154)2.01908726
123Abnormality of T cells (HP:0002843)2.01417011
124Supranuclear gaze palsy (HP:0000605)2.01382357
125Lactic acidosis (HP:0003128)2.01356161
126Excessive salivation (HP:0003781)2.01293892
127Drooling (HP:0002307)2.01293892
128Ankle clonus (HP:0011448)2.01055203
129Abnormality of renal resorption (HP:0011038)2.00731014
130Breast hypoplasia (HP:0003187)1.99894671
131Hypoplasia of the uterus (HP:0000013)1.98824442
132Abnormality of the pons (HP:0007361)1.97998506
133Lissencephaly (HP:0001339)1.96956274
134Impaired vibration sensation in the lower limbs (HP:0002166)1.96717636
135Abnormality of T cell physiology (HP:0011840)1.96544184
136Female pseudohermaphroditism (HP:0010458)1.95335899
137Hypoplasia of the pons (HP:0012110)1.94409102
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.93605358
139Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92888554
140Morphological abnormality of the pyramidal tract (HP:0002062)1.92550673
141Lethargy (HP:0001254)1.92010454
142Methylmalonic acidemia (HP:0002912)1.91659091
143Diplopia (HP:0000651)1.91531408
144Abnormality of binocular vision (HP:0011514)1.91531408
145Amblyopia (HP:0000646)1.91129400
146Increased intramyocellular lipid droplets (HP:0012240)1.90692646
147Inability to walk (HP:0002540)1.90565382
148Epileptiform EEG discharges (HP:0011182)1.90408094
149Pancytopenia (HP:0001876)1.88880380
150Genital tract atresia (HP:0001827)1.88767170
151Autoamputation (HP:0001218)1.88602096
152Nephrogenic diabetes insipidus (HP:0009806)1.88204140
153Tachypnea (HP:0002789)1.87186647
154Vaginal atresia (HP:0000148)1.86817195
155Split foot (HP:0001839)1.86578115
156T lymphocytopenia (HP:0005403)1.85625082
157Generalized myoclonic seizures (HP:0002123)1.85578188
158Confusion (HP:0001289)1.84948118
159Polyuria (HP:0000103)1.84914083
160Abnormality of T cell number (HP:0011839)1.84222657
161Patellar aplasia (HP:0006443)1.84029826
162Spastic tetraparesis (HP:0001285)1.82889834
163EEG with generalized epileptiform discharges (HP:0011198)1.82723276
164Psychosis (HP:0000709)1.81856204
165Abnormal respiratory epithelium morphology (HP:0012253)1.81539939
166Abnormal respiratory motile cilium morphology (HP:0005938)1.81539939
167Combined immunodeficiency (HP:0005387)1.80892899
168Abnormal hair whorl (HP:0010721)1.80826736
169Short tibia (HP:0005736)1.80797717
170Urinary urgency (HP:0000012)1.80736124
171Respiratory failure (HP:0002878)1.80654264
172Abnormality of glycine metabolism (HP:0010895)1.80455109
173Abnormality of serine family amino acid metabolism (HP:0010894)1.80455109
174Dysdiadochokinesis (HP:0002075)1.80436039
175Abnormal drinking behavior (HP:0030082)1.80285479
176Polydipsia (HP:0001959)1.80285479
177Male pseudohermaphroditism (HP:0000037)1.80140426
178Delayed myelination (HP:0012448)1.79382131
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.78221894
180CNS demyelination (HP:0007305)1.77968887
181Abnormal respiratory motile cilium physiology (HP:0012261)1.76410055
182Myositis (HP:0100614)1.75912168
183Aplasia/Hypoplasia of the patella (HP:0006498)1.74174371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.55439368
2CASK4.36636248
3NTRK32.98021232
4MARK12.97128379
5FRK2.87143540
6TLK12.69954635
7TAOK32.67204392
8PNCK2.52746188
9MAP2K72.32875220
10STK392.30135146
11EPHA42.26129063
12MAP3K42.20532037
13NUAK12.19031727
14OXSR12.13818539
15MAP4K12.04983807
16TNIK1.95024534
17NTRK21.89441344
18MINK11.89299539
19MAP3K121.88465258
20MAPK131.88411534
21ARAF1.87875463
22ITK1.85489606
23BCR1.81015931
24NTRK11.80296503
25GRK51.76925036
26NME11.69597568
27VRK21.66029214
28PRPF4B1.60722014
29PLK21.57610929
30MAP2K41.52713412
31PASK1.50681531
32GRK11.49718070
33ZAK1.47963519
34IKBKB1.47669953
35TEC1.47045089
36RPS6KA51.44564680
37MAP4K21.41219884
38TNK21.38177573
39DYRK21.38093397
40WNK41.37499631
41BRSK21.34888171
42BMPR1B1.33424560
43WNK31.31200791
44GRK71.30724375
45CSNK1G21.28640604
46LIMK11.28215435
47CAMK2B1.27263377
48CSNK1G31.26476917
49DAPK21.24679285
50AKT31.22740599
51KDR1.22431760
52CAMK2A1.22106173
53PKN11.21990770
54GRK61.21883616
55SGK2231.21665306
56SGK4941.21665306
57MUSK1.19652207
58PRKCG1.19624318
59MAP3K91.19281848
60PDK41.18142386
61PDK31.18142386
62PHKG11.16335262
63PHKG21.16335262
64ADRBK21.15098914
65UHMK11.14253688
66CAMKK21.12439735
67PAK61.12040009
68CDK81.11936368
69SCYL21.09910229
70MARK31.06775319
71SYK1.06542945
72BUB11.04733711
73CDK51.03424870
74LCK1.02650679
75JAK31.01565882
76KSR11.00964117
77RIPK41.00030317
78MST40.98137173
79STK160.96180466
80MAP2K60.95777597
81BMPR20.95563207
82PAK30.95128604
83PRKCE0.94634682
84MAP3K110.93080440
85VRK10.92653704
86CAMK2G0.90448901
87PBK0.90437178
88CDK190.90094769
89OBSCN0.87471634
90IKBKE0.87425519
91BTK0.86506223
92FGR0.85967964
93ADRBK10.85495561
94CSNK1A1L0.85398942
95KSR20.84296087
96CSNK1G10.83897342
97MAP3K140.83039936
98CDK140.82314190
99MAPKAPK50.80926680
100RPS6KA60.79189129
101ERBB40.78441664
102SIK30.77152616
103CAMK2D0.77066002
104CDK180.76308521
105LATS20.76227445
106ROCK20.71974515
107PIK3CA0.71590046
108CDK150.71189275
109LYN0.70150647
110TBK10.69538584
111TRIM280.69495960
112STK110.69305060
113BCKDK0.68613503
114HCK0.68107709
115FLT30.67724578
116FES0.66943182
117DYRK1A0.66491098
118CAMKK10.65767683
119WNK10.63741620
120TGFBR10.63631633
121PDK20.61000435
122ZAP700.59583854
123IRAK40.58854908
124SGK20.58525527
125CDK11A0.58480083
126PTK2B0.57661591
127BRAF0.56495182
128PRKACA0.55876473
129BRSK10.55421308
130ATR0.54748548
131MAPKAPK30.53230118
132MKNK10.52108129
133ACVR1B0.51770247
134PINK10.48441175
135MKNK20.46886614
136KIT0.46418385
137CHUK0.46012483
138RPS6KL10.45954210
139RPS6KC10.45954210
140MAP2K10.45597670
141PRKCZ0.45056459
142EIF2AK10.44853821
143CSF1R0.42423539
144ERBB30.42373552
145RPS6KB10.42282141
146MAPK120.42106125
147YES10.41472900
148NEK20.41299964
149PRKCA0.40864803
150PRKCQ0.40562274
151PRKG10.40509734
152ABL20.40362395
153JAK10.40269272
154ABL10.38991310
155MYLK0.38354827
156NEK60.37731879
157DAPK10.37721099
158MAP3K70.37531879
159CAMK1G0.35658121
160MAPK40.34753808
161INSRR0.34401174
162MAP3K130.34325490
163PRKACB0.34083843
164CSNK2A10.32966659
165SGK10.31894474
166IGF1R0.30028275

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.54679995
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.43380062
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.21671636
4Nicotine addiction_Homo sapiens_hsa050332.96097497
5RNA polymerase_Homo sapiens_hsa030202.85520952
6Homologous recombination_Homo sapiens_hsa034402.80209829
7Ribosome_Homo sapiens_hsa030102.73795716
8Parkinsons disease_Homo sapiens_hsa050122.67989114
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42809119
10Linoleic acid metabolism_Homo sapiens_hsa005912.39493496
11Fatty acid elongation_Homo sapiens_hsa000622.32910807
12Alzheimers disease_Homo sapiens_hsa050102.32379258
13Primary immunodeficiency_Homo sapiens_hsa053402.28625896
14Butanoate metabolism_Homo sapiens_hsa006502.26302103
15Synaptic vesicle cycle_Homo sapiens_hsa047212.25536137
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20570974
17Collecting duct acid secretion_Homo sapiens_hsa049662.19452711
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19413583
19Steroid biosynthesis_Homo sapiens_hsa001002.13241798
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08752320
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98261408
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.95511795
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85405151
24Huntingtons disease_Homo sapiens_hsa050161.83946416
25GABAergic synapse_Homo sapiens_hsa047271.82460435
26Sulfur relay system_Homo sapiens_hsa041221.74994617
27Fanconi anemia pathway_Homo sapiens_hsa034601.73970255
28Selenocompound metabolism_Homo sapiens_hsa004501.71211185
29Basal transcription factors_Homo sapiens_hsa030221.68428911
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.64700509
31Cardiac muscle contraction_Homo sapiens_hsa042601.60242550
32Glutamatergic synapse_Homo sapiens_hsa047241.57317733
33One carbon pool by folate_Homo sapiens_hsa006701.56351404
34Vitamin B6 metabolism_Homo sapiens_hsa007501.52883304
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51934230
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51509237
37Graft-versus-host disease_Homo sapiens_hsa053321.48332848
38Serotonergic synapse_Homo sapiens_hsa047261.44170838
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42102258
40Autoimmune thyroid disease_Homo sapiens_hsa053201.42032679
41Morphine addiction_Homo sapiens_hsa050321.41518266
42Allograft rejection_Homo sapiens_hsa053301.39681251
43Pyruvate metabolism_Homo sapiens_hsa006201.39569623
44Pyrimidine metabolism_Homo sapiens_hsa002401.39198865
45Taste transduction_Homo sapiens_hsa047421.38211369
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.37123817
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36713039
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36678008
49Circadian entrainment_Homo sapiens_hsa047131.27775841
50Propanoate metabolism_Homo sapiens_hsa006401.25758794
51Asthma_Homo sapiens_hsa053101.22624304
52Amphetamine addiction_Homo sapiens_hsa050311.21220666
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17964384
54Mismatch repair_Homo sapiens_hsa034301.16774670
55Dopaminergic synapse_Homo sapiens_hsa047281.16320658
56Type I diabetes mellitus_Homo sapiens_hsa049401.16209806
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15941551
58Sulfur metabolism_Homo sapiens_hsa009201.14864628
59Histidine metabolism_Homo sapiens_hsa003401.14849216
60Arachidonic acid metabolism_Homo sapiens_hsa005901.14050466
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12371320
62Long-term potentiation_Homo sapiens_hsa047201.11220467
63Salivary secretion_Homo sapiens_hsa049701.10952816
64Arginine biosynthesis_Homo sapiens_hsa002201.09167440
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07741963
66SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07512587
67Purine metabolism_Homo sapiens_hsa002301.07499460
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06968720
69Peroxisome_Homo sapiens_hsa041461.06686259
70Vibrio cholerae infection_Homo sapiens_hsa051101.06219022
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02383336
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01850721
73Base excision repair_Homo sapiens_hsa034101.01616806
74Nitrogen metabolism_Homo sapiens_hsa009101.01244440
75Fatty acid metabolism_Homo sapiens_hsa012121.00630146
76Long-term depression_Homo sapiens_hsa047300.98772972
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98552156
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98507126
79Caffeine metabolism_Homo sapiens_hsa002320.97728801
80Nucleotide excision repair_Homo sapiens_hsa034200.96349516
81Phenylalanine metabolism_Homo sapiens_hsa003600.96265544
82Tyrosine metabolism_Homo sapiens_hsa003500.93679763
83Olfactory transduction_Homo sapiens_hsa047400.92253876
84Ether lipid metabolism_Homo sapiens_hsa005650.90459412
85RNA degradation_Homo sapiens_hsa030180.90005615
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87508608
87Tryptophan metabolism_Homo sapiens_hsa003800.87380344
88Cholinergic synapse_Homo sapiens_hsa047250.86741608
89Cocaine addiction_Homo sapiens_hsa050300.86488285
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85406836
91Insulin secretion_Homo sapiens_hsa049110.84370617
92Bile secretion_Homo sapiens_hsa049760.83991906
93Phototransduction_Homo sapiens_hsa047440.82875652
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80861812
95Renin secretion_Homo sapiens_hsa049240.80065399
96Calcium signaling pathway_Homo sapiens_hsa040200.75722746
97Fatty acid degradation_Homo sapiens_hsa000710.74995200
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74630054
99Axon guidance_Homo sapiens_hsa043600.74393418
100Gastric acid secretion_Homo sapiens_hsa049710.72747976
101beta-Alanine metabolism_Homo sapiens_hsa004100.70497380
102Antigen processing and presentation_Homo sapiens_hsa046120.69705619
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.69607097
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69593626
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69506868
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68994809
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67986471
108Regulation of autophagy_Homo sapiens_hsa041400.67927108
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66784908
110Proteasome_Homo sapiens_hsa030500.66198920
111Chemical carcinogenesis_Homo sapiens_hsa052040.65162836
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65071045
113RNA transport_Homo sapiens_hsa030130.64653198
114Arginine and proline metabolism_Homo sapiens_hsa003300.63728921
115T cell receptor signaling pathway_Homo sapiens_hsa046600.62022012
116Metabolic pathways_Homo sapiens_hsa011000.61579085
117Complement and coagulation cascades_Homo sapiens_hsa046100.60209869
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59677921
119PPAR signaling pathway_Homo sapiens_hsa033200.59668927
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58918003
121DNA replication_Homo sapiens_hsa030300.58723913
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.57752125
123Non-homologous end-joining_Homo sapiens_hsa034500.57430426
124Rheumatoid arthritis_Homo sapiens_hsa053230.55472259
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54511471
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.54453209
127Gap junction_Homo sapiens_hsa045400.54414878
128Protein export_Homo sapiens_hsa030600.54305329
129ABC transporters_Homo sapiens_hsa020100.50902456
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.50322665
131Glycerolipid metabolism_Homo sapiens_hsa005610.50302013
132Hematopoietic cell lineage_Homo sapiens_hsa046400.49082503
133Oxytocin signaling pathway_Homo sapiens_hsa049210.49059273
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.48264667
135Spliceosome_Homo sapiens_hsa030400.47916825
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46926282
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46232219
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45718600
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45536877
140Viral myocarditis_Homo sapiens_hsa054160.44663151
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44422671
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44401584
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43845845
144Carbon metabolism_Homo sapiens_hsa012000.43351501
145Phagosome_Homo sapiens_hsa041450.42346760
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40874322
147Mineral absorption_Homo sapiens_hsa049780.35598634
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35579624
149Retinol metabolism_Homo sapiens_hsa008300.35116873
150NF-kappa B signaling pathway_Homo sapiens_hsa040640.33710789
151Prion diseases_Homo sapiens_hsa050200.33175803
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33050987
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31518333
154Vitamin digestion and absorption_Homo sapiens_hsa049770.31110956

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »