THEM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingoid metabolic process (GO:0046519)7.80713885
2keratinocyte differentiation (GO:0030216)7.70030436
3multicellular organismal water homeostasis (GO:0050891)7.59677608
4keratinocyte proliferation (GO:0043616)7.52215573
5sphingosine metabolic process (GO:0006670)6.68370033
6glucosamine-containing compound catabolic process (GO:1901072)6.58116014
7interferon-gamma secretion (GO:0072643)6.45830217
8long-chain fatty acid biosynthetic process (GO:0042759)6.45590626
9regulation of phospholipase A2 activity (GO:0032429)6.40894750
10water homeostasis (GO:0030104)6.39991600
11neutrophil activation involved in immune response (GO:0002283)6.14093453
12epidermal cell differentiation (GO:0009913)6.03935493
13diol metabolic process (GO:0034311)5.99717020
14fatty acid elongation (GO:0030497)5.90136037
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.63196717
16protein neddylation (GO:0045116)5.61441277
17viral transcription (GO:0019083)5.57860790
18regulation of platelet aggregation (GO:0090330)5.54447567
19peptide cross-linking (GO:0018149)5.48223558
20thrombin receptor signaling pathway (GO:0070493)5.38972352
21regulation of ruffle assembly (GO:1900027)5.34695230
22negative regulation of thymocyte apoptotic process (GO:0070244)5.33840193
23regulation of chemokine secretion (GO:0090196)5.27783825
24translational termination (GO:0006415)5.26426464
25positive regulation of interleukin-8 secretion (GO:2000484)5.15952055
26epidermis development (GO:0008544)5.12100432
27regulation of cell proliferation involved in kidney development (GO:1901722)5.11613918
28regulation of platelet activation (GO:0010543)4.99675999
29regulation of hypersensitivity (GO:0002883)4.95500556
30hemidesmosome assembly (GO:0031581)4.86885089
31negative regulation of homotypic cell-cell adhesion (GO:0034111)4.82717226
32ribosomal small subunit biogenesis (GO:0042274)4.80842325
33linoleic acid metabolic process (GO:0043651)4.67763697
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.56596957
35blood coagulation, intrinsic pathway (GO:0007597)4.55393321
36keratinocyte development (GO:0003334)4.54256105
37intermediate filament organization (GO:0045109)4.42911141
38negative regulation of platelet activation (GO:0010544)4.42169592
39positive regulation of macrophage differentiation (GO:0045651)4.40346930
40platelet aggregation (GO:0070527)4.37898641
41positive regulation of chemokine secretion (GO:0090197)4.34774653
42molting cycle (GO:0042303)4.32507147
43hair cycle (GO:0042633)4.32507147
44cyclooxygenase pathway (GO:0019371)4.26795106
45adenosine receptor signaling pathway (GO:0001973)4.25976834
46positive regulation of endothelial cell differentiation (GO:0045603)4.23919117
47skin morphogenesis (GO:0043589)4.22798376
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.18929746
49regulation of memory T cell differentiation (GO:0043380)4.18875130
50leukocyte migration involved in inflammatory response (GO:0002523)4.18753510
51viral life cycle (GO:0019058)4.16209019
52protein targeting to ER (GO:0045047)4.14000487
53translational elongation (GO:0006414)4.13015505
54cotranslational protein targeting to membrane (GO:0006613)4.11634986
55prostanoid biosynthetic process (GO:0046457)4.08640568
56prostaglandin biosynthetic process (GO:0001516)4.08640568
57negative regulation of heart rate (GO:0010459)4.04125712
58establishment of protein localization to endoplasmic reticulum (GO:0072599)4.03342090
59detection of bacterium (GO:0016045)4.00753864
60cellular protein complex disassembly (GO:0043624)3.98647604
61phosphatidylinositol acyl-chain remodeling (GO:0036149)3.97070152
62regulation of interleukin-8 secretion (GO:2000482)3.96631146
63protein localization to endoplasmic reticulum (GO:0070972)3.89136049
64negative regulation of interleukin-2 production (GO:0032703)3.87491258
65lipoxygenase pathway (GO:0019372)3.86720209
66negative regulation of stress fiber assembly (GO:0051497)3.83559079
67regulation of transforming growth factor beta1 production (GO:0032908)3.83436407
68negative regulation of acute inflammatory response (GO:0002674)3.81656635
69regulation of integrin-mediated signaling pathway (GO:2001044)3.81414103
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80785407
71positive regulation of interleukin-4 production (GO:0032753)3.80055333
72neutrophil activation (GO:0042119)3.78208556
73maturation of SSU-rRNA (GO:0030490)3.78011042
74regulation of homotypic cell-cell adhesion (GO:0034110)3.77905129
75polyamine biosynthetic process (GO:0006596)3.77801352
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.76862795
77angiogenesis involved in wound healing (GO:0060055)3.76573143
78megakaryocyte development (GO:0035855)3.72282354
79negative regulation of norepinephrine secretion (GO:0010700)3.71852397
80negative regulation of interferon-gamma production (GO:0032689)3.69766801
81negative regulation of kidney development (GO:0090185)3.53791012
82cardiac right ventricle morphogenesis (GO:0003215)3.53163218
83gland morphogenesis (GO:0022612)3.51072550
84purinergic nucleotide receptor signaling pathway (GO:0035590)3.49293467
85positive regulation of systemic arterial blood pressure (GO:0003084)3.48754876
86phosphatidylserine acyl-chain remodeling (GO:0036150)3.46466668
87ribosomal small subunit assembly (GO:0000028)3.45670002
88positive regulation of mast cell activation (GO:0033005)3.45493081
89ectoderm development (GO:0007398)3.44443589
90negative regulation of T cell apoptotic process (GO:0070233)3.43780477
91negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.41887164
92atrioventricular valve morphogenesis (GO:0003181)3.41510771
93amino sugar catabolic process (GO:0046348)3.41450299
94positive regulation of glomerulus development (GO:0090193)3.40622102
95platelet degranulation (GO:0002576)3.39813889
96negative regulation of T cell mediated immunity (GO:0002710)3.37896526
97low-density lipoprotein particle remodeling (GO:0034374)3.37409623
98platelet formation (GO:0030220)3.37031053
99negative regulation of response to food (GO:0032096)3.35987414
100negative regulation of appetite (GO:0032099)3.35987414
101primary alcohol catabolic process (GO:0034310)3.34327517
102regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.34145207
103homotypic cell-cell adhesion (GO:0034109)3.33954484
104cellular response to interferon-alpha (GO:0035457)3.33803517
105prostanoid metabolic process (GO:0006692)3.32355648
106prostaglandin metabolic process (GO:0006693)3.32355648
107detection of other organism (GO:0098543)3.31899604
108granulocyte activation (GO:0036230)3.30776361
109protein complex disassembly (GO:0043241)3.29055958
110regulation of regulatory T cell differentiation (GO:0045589)3.26635480
111negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.26225381
112regulation of integrin activation (GO:0033623)3.25379667
113G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.23874051
114platelet activation (GO:0030168)3.21865201
115positive regulation of cAMP-mediated signaling (GO:0043950)3.20235886
116translational initiation (GO:0006413)3.18852310
117positive regulation of vesicle fusion (GO:0031340)3.18760927
118regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18320576
119regulation of macrophage derived foam cell differentiation (GO:0010743)3.18254988
120unsaturated fatty acid biosynthetic process (GO:0006636)3.16723105
121negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.15795211
122chemical homeostasis within a tissue (GO:0048875)3.12577573
123regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.12140166
124positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.11347315
125arachidonic acid secretion (GO:0050482)3.10872472
126icosanoid secretion (GO:0032309)3.10872472
127inflammatory response to antigenic stimulus (GO:0002437)3.07596745
128regulation of MHC class II biosynthetic process (GO:0045346)3.07299818
129positive regulation of blood coagulation (GO:0030194)3.07273433
130positive regulation of hemostasis (GO:1900048)3.07273433
131glutathione biosynthetic process (GO:0006750)3.07044635
132fusion of sperm to egg plasma membrane (GO:0007342)3.04760771
133mast cell activation (GO:0045576)3.02957518
134phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.02824317
135regulation of thymocyte apoptotic process (GO:0070243)3.02408295
136negative regulation of lipase activity (GO:0060192)3.02052239
137establishment of tissue polarity (GO:0007164)3.01560780
138establishment of planar polarity (GO:0001736)3.01560780
139protein targeting to membrane (GO:0006612)3.00102604
140phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.99930870
141macromolecular complex disassembly (GO:0032984)2.99740769
142regulation of glomerular filtration (GO:0003093)2.97745916
143purinergic receptor signaling pathway (GO:0035587)2.97215936
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96765835
145eyelid development in camera-type eye (GO:0061029)2.94608740
146regulation of cholesterol efflux (GO:0010874)2.94512840
147G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.92464595
148leukocyte degranulation (GO:0043299)2.90517477
149regulation of lipoprotein metabolic process (GO:0050746)2.90080863
150hepatocyte apoptotic process (GO:0097284)2.89573672
151tolerance induction (GO:0002507)2.87585160
152positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.86957928
153fibrinolysis (GO:0042730)2.86481768
154positive regulation of Rho protein signal transduction (GO:0035025)2.85138073
155positive regulation of receptor recycling (GO:0001921)2.84609505
156nonribosomal peptide biosynthetic process (GO:0019184)2.84370604
157antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.77867671
158negative regulation of monooxygenase activity (GO:0032769)2.77137183
159negative regulation of calcium ion transport into cytosol (GO:0010523)2.75561368
160positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74296585
161antigen processing and presentation via MHC class Ib (GO:0002475)2.72785490
162regulation of interleukin-17 production (GO:0032660)2.72713512
163negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.71352087
164regulation of endothelial cell differentiation (GO:0045601)2.71265352
165positive regulation of immunoglobulin mediated immune response (GO:0002891)2.71003220
166positive regulation of B cell mediated immunity (GO:0002714)2.71003220
167negative regulation of heart contraction (GO:0045822)2.69131771
168regulation of blood coagulation (GO:0030193)2.68293827
169regulation of hemostasis (GO:1900046)2.68293827
170negative regulation of blood coagulation (GO:0030195)2.67992110
171negative regulation of hemostasis (GO:1900047)2.67992110
172high-density lipoprotein particle remodeling (GO:0034375)2.67819792
173positive regulation of coagulation (GO:0050820)2.67371083
174extracellular fibril organization (GO:0043206)2.66804532
175negative regulation of cell killing (GO:0031342)2.66397465
176negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66397465
177negative regulation of neural precursor cell proliferation (GO:2000178)2.66119709
178positive regulation of interleukin-17 production (GO:0032740)2.65881134
179termination of signal transduction (GO:0023021)2.64373972
180termination of G-protein coupled receptor signaling pathway (GO:0038032)2.64005620
181desmosome organization (GO:0002934)14.9643662
182establishment of skin barrier (GO:0061436)12.0902346
183regulation of water loss via skin (GO:0033561)11.0674234
184keratinization (GO:0031424)11.0096370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.41656578
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.18968770
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.95181125
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.66578488
5SCL_19346495_ChIP-Seq_HPC-7_Human3.34638157
6P63_26484246_Chip-Seq_KERATINOCYTES_Human3.15654767
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09979802
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05133916
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.02593426
10SOX9_24532713_ChIP-Seq_HFSC_Mouse2.87879502
11GATA1_19941826_ChIP-Seq_K562_Human2.85904896
12GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.66240687
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.52445512
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.50085944
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48733410
16GATA2_19941826_ChIP-Seq_K562_Human2.47151330
17GATA1_19941827_ChIP-Seq_MEL_Mouse2.42356574
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.39384928
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.32722839
20LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.32240737
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29381890
22RUNX_20019798_ChIP-Seq_JUKART_Human2.26832808
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24745335
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19917738
25* GATA2_21666600_ChIP-Seq_HMVEC_Human2.16372949
26TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.14711910
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.11952762
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04366301
29TP63_17297297_ChIP-ChIP_HaCaT_Human16.2609000
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.99058125
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.98696621
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.95842819
33SPI1_23127762_ChIP-Seq_K562_Human1.92767854
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92712066
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92712066
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85172877
37ZNF263_19887448_ChIP-Seq_K562_Human1.82995785
38GATA1_22383799_ChIP-Seq_G1ME_Mouse1.81231092
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81079786
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.78498242
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.77777049
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72074117
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69329810
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65622685
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64348271
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63342585
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63121491
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.59736738
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57140663
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57065438
51SOX2_20726797_ChIP-Seq_SW620_Human1.56987382
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53348305
53TP63_23658742_ChIP-Seq_EP156T_Human1.47053729
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43553788
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43460535
56* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42400430
57GATA1_19941827_ChIP-Seq_MEL86_Mouse1.40579920
58MYB_26560356_Chip-Seq_TH2_Human1.38149926
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36577655
60UTX_26944678_Chip-Seq_JUKART_Human1.34872264
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33702453
62BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.33367205
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31871339
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31223848
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31046102
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.30646308
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30134122
68CJUN_26792858_Chip-Seq_BT549_Human1.28414415
69TP63_22573176_ChIP-Seq_HFKS_Human1.28207658
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25671444
71MAF_26560356_Chip-Seq_TH1_Human1.23909510
72GATA3_27048872_Chip-Seq_THYMUS_Human1.23110564
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22300814
74GATA3_26560356_Chip-Seq_TH2_Human1.20504822
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.19521744
76SPI1_20517297_ChIP-Seq_HL60_Human1.16291873
77KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.15984400
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15282898
79* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.14719015
80KLF5_25053715_ChIP-Seq_YYC3_Human1.14685307
81AR_21572438_ChIP-Seq_LNCaP_Human1.13821273
82HTT_18923047_ChIP-ChIP_STHdh_Human1.12589389
83GATA1_22025678_ChIP-Seq_K562_Human1.12126010
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.11628873
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11427055
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09775444
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07800766
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07261587
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07132588
90CDX2_20551321_ChIP-Seq_CACO-2_Human1.05278678
91NCOR1_26117541_ChIP-Seq_K562_Human1.05242742
92MYB_26560356_Chip-Seq_TH1_Human1.05041554
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04399789
94GATA4_25053715_ChIP-Seq_YYC3_Human1.02159776
95RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01200354
96CEBPB_22108803_ChIP-Seq_LS180_Human1.00621006
97TCF7_22412390_ChIP-Seq_EML_Mouse0.99604079
98* RXR_22158963_ChIP-Seq_LIVER_Mouse0.99028430
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96208656
100GATA3_24758297_ChIP-Seq_MCF-7_Human0.96194312
101TP53_18474530_ChIP-ChIP_U2OS_Human0.95496314
102RXR_22108803_ChIP-Seq_LS180_Human0.95190239
103* GATA6_21074721_ChIP-Seq_CACO-2_Human0.94540556
104ATF3_27146783_Chip-Seq_COLON_Human0.93949452
105IRF8_22096565_ChIP-ChIP_GC-B_Human0.92665882
106AHR_22903824_ChIP-Seq_MCF-7_Human0.90524507
107SPI1_23547873_ChIP-Seq_NB4_Human0.90486571
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90174672
109EZH2_22144423_ChIP-Seq_EOC_Human0.88016459
110BCOR_27268052_Chip-Seq_Bcells_Human0.87322841
111BCAT_22108803_ChIP-Seq_LS180_Human0.86921575
112SMAD_19615063_ChIP-ChIP_OVARY_Human0.86819021
113SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86426602
114BCL6_27268052_Chip-Seq_Bcells_Human0.85222654
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84586432
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.83521550
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83253624
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83190135
119YY1_22570637_ChIP-Seq_MALME-3M_Human0.82860489
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82801206
121OCT1_27270436_Chip-Seq_PROSTATE_Human0.82063676
122CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81409476
123GATA6_25053715_ChIP-Seq_YYC3_Human0.81338431
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81281906
125* RACK7_27058665_Chip-Seq_MCF-7_Human0.80763216
126EZH2_27304074_Chip-Seq_ESCs_Mouse0.80717495
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80610789
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80439358
129LXR_22158963_ChIP-Seq_LIVER_Mouse0.80097818
130UBF1/2_26484160_Chip-Seq_HMECs_Human0.79970431
131CTCF_27219007_Chip-Seq_Bcells_Human0.79916126
132SMRT_27268052_Chip-Seq_Bcells_Human0.79425009
133VDR_24763502_ChIP-Seq_THP-1_Human0.79306110
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78589203
135P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.75756240
136SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.75679075
137EED_16625203_ChIP-ChIP_MESCs_Mouse0.74733321
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74310544
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72461916
140* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.72295518
141TCF4_22108803_ChIP-Seq_LS180_Human0.72049375
142SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71634273
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.71394337
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70951832
145UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70930995
146* SA1_27219007_Chip-Seq_ERYTHROID_Human0.70694966
147EZH2_27294783_Chip-Seq_ESCs_Mouse0.70527479
148BMI1_23680149_ChIP-Seq_NPCS_Mouse0.69714731
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68581240
150CTCF_20526341_ChIP-Seq_ESCs_Human0.65853842
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.63975741
152JARID2_20075857_ChIP-Seq_MESCs_Mouse0.63530070
153* SA1_27219007_Chip-Seq_Bcells_Human0.62962057
154HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.62547305
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.62200493
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.62200493
157SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.61702346
158GATA3_21867929_ChIP-Seq_TH1_Mouse0.60989635
159PPARA_22158963_ChIP-Seq_LIVER_Mouse0.60786423
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.60689735
161FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60430865
162* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60239487
163PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.60128760
164* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59651661
165DNAJC2_21179169_ChIP-ChIP_NT2_Human0.59447432
166SMAD3_21741376_ChIP-Seq_HESCs_Human0.59319216
167AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59302897
168* LXR_22292898_ChIP-Seq_THP-1_Human0.58982794
169SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.58974275
170SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.58670961
171NANOG_20526341_ChIP-Seq_ESCs_Human0.58412515
172RNF2_27304074_Chip-Seq_ESCs_Mouse0.57769596
173* HNFA_21074721_ChIP-Seq_CACO-2_Human0.57769320
174FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57714452
175ERG_21242973_ChIP-ChIP_JURKAT_Human0.56308920
176* RBPJ_21746931_ChIP-Seq_IB4_Human0.55972068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.36990178
2MP0005464_abnormal_platelet_physiology7.53164437
3MP0010234_abnormal_vibrissa_follicle6.62055481
4MP0005275_abnormal_skin_tensile5.46293307
5MP0003941_abnormal_skin_development5.39367648
6MP0005501_abnormal_skin_physiology5.10652843
7MP0004381_abnormal_hair_follicle4.31729968
8MP0010678_abnormal_skin_adnexa3.40974637
9MP0001216_abnormal_epidermal_layer3.39813699
10MP0003724_increased_susceptibility_to3.31689012
11MP0000383_abnormal_hair_follicle3.21621045
12MP0002060_abnormal_skin_morphology3.18483091
13MP0010771_integument_phenotype3.11098062
14MP0002098_abnormal_vibrissa_morphology3.08855196
15MP0002254_reproductive_system_inflammat3.05632210
16MP0000579_abnormal_nail_morphology2.91911399
17MP0003453_abnormal_keratinocyte_physiol2.85427879
18MP0003303_peritoneal_inflammation2.83552000
19MP0000566_synostosis2.77500501
20MP0000647_abnormal_sebaceous_gland2.57353876
21MP0009379_abnormal_foot_pigmentation2.48762193
22MP0001835_abnormal_antigen_presentation2.40204843
23MP0005451_abnormal_body_composition2.39339358
24MP0005671_abnormal_response_to2.36373763
25MP0004947_skin_inflammation2.33279126
26MP0005083_abnormal_biliary_tract2.31617859
27MP0000377_abnormal_hair_follicle2.30035887
28MP0000467_abnormal_esophagus_morphology2.28625011
29MP0001346_abnormal_lacrimal_gland1.96031648
30MP0000427_abnormal_hair_cycle1.92655170
31MP0003300_gastrointestinal_ulcer1.87990045
32MP0005000_abnormal_immune_tolerance1.82448604
33MP0004185_abnormal_adipocyte_glucose1.75028877
34MP0000015_abnormal_ear_pigmentation1.72528872
35MP0010155_abnormal_intestine_physiology1.72428704
36MP0001191_abnormal_skin_condition1.69725271
37MP0005387_immune_system_phenotype1.68036807
38MP0001790_abnormal_immune_system1.68036807
39MP0003566_abnormal_cell_adhesion1.65549870
40MP0000685_abnormal_immune_system1.64358742
41MP0009931_abnormal_skin_appearance1.64176913
42MP0002009_preneoplasia1.62305041
43MP0001800_abnormal_humoral_immune1.61438647
44MP0000762_abnormal_tongue_morphology1.58058471
45MP0009333_abnormal_splenocyte_physiolog1.54236325
46MP0002398_abnormal_bone_marrow1.50195136
47MP0002723_abnormal_immune_serum1.46368907
48MP0009780_abnormal_chondrocyte_physiolo1.46248883
49MP0002736_abnormal_nociception_after1.41362852
50MP0001243_abnormal_dermal_layer1.35694755
51MP0003866_abnormal_defecation1.35547605
52MP0000343_altered_response_to1.34502814
53MP0000858_altered_metastatic_potential1.33951240
54MP0002452_abnormal_antigen_presenting1.32294858
55MP0004510_myositis1.31789320
56MP0000367_abnormal_coat/_hair1.30953834
57MP0002138_abnormal_hepatobiliary_system1.30396506
58MP0002420_abnormal_adaptive_immunity1.27377207
59MP0008004_abnormal_stomach_pH1.27267356
60MP0008872_abnormal_physiological_respon1.26025932
61MP0001819_abnormal_immune_cell1.25474551
62MP0005085_abnormal_gallbladder_physiolo1.22829785
63MP0003705_abnormal_hypodermis_morpholog1.22327495
64MP0001663_abnormal_digestive_system1.19188295
65MP0010352_gastrointestinal_tract_polyps1.17954537
66MP0005025_abnormal_response_to1.16629743
67MP0003183_abnormal_peptide_metabolism1.14520959
68MP0000230_abnormal_systemic_arterial1.13864699
69MP0000703_abnormal_thymus_morphology1.13236435
70MP0003136_yellow_coat_color1.13069946
71MP0002722_abnormal_immune_system1.11803226
72MP0003828_pulmonary_edema1.09081697
73MP0003879_abnormal_hair_cell1.07881869
74MP0001340_abnormal_eyelid_morphology1.07843433
75MP0000689_abnormal_spleen_morphology1.07597068
76MP0001545_abnormal_hematopoietic_system1.05525901
77MP0005397_hematopoietic_system_phenotyp1.05525901
78MP0005167_abnormal_blood-brain_barrier1.05524791
79MP0005365_abnormal_bile_salt1.03756145
80MP0000716_abnormal_immune_system1.03726959
81MP0001188_hyperpigmentation1.03500513
82MP0002429_abnormal_blood_cell1.03049776
83MP0002419_abnormal_innate_immunity1.02034397
84MP0001845_abnormal_inflammatory_respons1.01166084
85MP0009785_altered_susceptibility_to0.99217965
86MP0000249_abnormal_blood_vessel0.98834206
87MP0009763_increased_sensitivity_to0.98698598
88MP0001851_eye_inflammation0.97642173
89MP0003252_abnormal_bile_duct0.94994585
90MP0003011_delayed_dark_adaptation0.94067317
91MP0009765_abnormal_xenobiotic_induced0.93160462
92MP0008874_decreased_physiological_sensi0.91972726
93MP0004782_abnormal_surfactant_physiolog0.89595984
94MP0002998_abnormal_bone_remodeling0.89127454
95MP0003191_abnormal_cellular_cholesterol0.87773252
96MP0004084_abnormal_cardiac_muscle0.87612804
97MP0003436_decreased_susceptibility_to0.86699563
98MP0003878_abnormal_ear_physiology0.85604383
99MP0005377_hearing/vestibular/ear_phenot0.85604383
100MP0002405_respiratory_system_inflammati0.83105058
101MP0005084_abnormal_gallbladder_morpholo0.81981157
102MP0003656_abnormal_erythrocyte_physiolo0.80953007
103MP0005075_abnormal_melanosome_morpholog0.79294233
104MP0005058_abnormal_lysosome_morphology0.78781917
105MP0001765_abnormal_ion_homeostasis0.78769913
106MP0010329_abnormal_lipoprotein_level0.76752655
107MP0009764_decreased_sensitivity_to0.75630961
108MP0005023_abnormal_wound_healing0.75602523
109MP0005381_digestive/alimentary_phenotyp0.75057722
110MP0008569_lethality_at_weaning0.74284143
111MP0000627_abnormal_mammary_gland0.73488471
112MP0005409_darkened_coat_color0.73338965
113MP0001984_abnormal_olfaction0.72859175
114MP0002006_tumorigenesis0.70594797
115MP0002234_abnormal_pharynx_morphology0.70586246
116MP0010030_abnormal_orbit_morphology0.70128614
117MP0005076_abnormal_cell_differentiation0.65775363
118MP0000516_abnormal_urinary_system0.64871327
119MP0005367_renal/urinary_system_phenotyp0.64871327
120MP0000465_gastrointestinal_hemorrhage0.64817613
121MP0003315_abnormal_perineum_morphology0.62585666
122MP0001784_abnormal_fluid_regulation0.58427423
123MP0002095_abnormal_skin_pigmentation0.57707584
124MP0002877_abnormal_melanocyte_morpholog0.57054930
125MP0002177_abnormal_outer_ear0.53366537
126MP0002166_altered_tumor_susceptibility0.52632885
127MP0003638_abnormal_response/metabolism_0.52448463
128MP0002148_abnormal_hypersensitivity_rea0.51027216
129MP0002249_abnormal_larynx_morphology0.50357142
130MP0004019_abnormal_vitamin_homeostasis0.49749346
131MP0009384_cardiac_valve_regurgitation0.49668878
132MP0002277_abnormal_respiratory_mucosa0.48255552
133MP0009053_abnormal_anal_canal0.48153604
134MP0005666_abnormal_adipose_tissue0.47919365
135MP0002090_abnormal_vision0.47524174
136MP0000538_abnormal_urinary_bladder0.44928732
137MP0003938_abnormal_ear_development0.44740567
138MP0005508_abnormal_skeleton_morphology0.44079289
139MP0003755_abnormal_palate_morphology0.44058274
140MP0002282_abnormal_trachea_morphology0.40236882
141MP0002111_abnormal_tail_morphology0.38490672
142MP0009250_abnormal_appendicular_skeleto0.37520906
143MP0004272_abnormal_basement_membrane0.36368567
144MP0003385_abnormal_body_wall0.36081415
145MP0000613_abnormal_salivary_gland0.35853697
146MP0000470_abnormal_stomach_morphology0.32076505
147MP0001666_abnormal_nutrient_absorption0.31622541
148MP0004264_abnormal_extraembryonic_tissu0.31191960
149MP0003950_abnormal_plasma_membrane0.30704713
150MP0005390_skeleton_phenotype0.27924156
151MP0005187_abnormal_penis_morphology0.27750456
152MP0003718_maternal_effect0.27542066
153MP0002132_abnormal_respiratory_system0.27201968
154MP0003763_abnormal_thymus_physiology0.25794833
155MP0006054_spinal_hemorrhage0.25553554
156MP0008961_abnormal_basal_metabolism0.25544944
157MP0001177_atelectasis0.25447248
158MP0005174_abnormal_tail_pigmentation0.22673208
159MP0004858_abnormal_nervous_system0.22275866
160MP0005375_adipose_tissue_phenotype0.21676676
161MP0000432_abnormal_head_morphology0.21349231
162MP0001542_abnormal_bone_strength0.20653545
163MP0003936_abnormal_reproductive_system0.20446705
164MP0005248_abnormal_Harderian_gland0.19389810
165MP0001533_abnormal_skeleton_physiology0.19234135
166MP0000537_abnormal_urethra_morphology0.18988212
167MP0002109_abnormal_limb_morphology0.18659814

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.37744773
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)9.08620593
3Menorrhagia (HP:0000132)8.34616422
4Increased mean platelet volume (HP:0011877)8.17238697
5Congenital ichthyosiform erythroderma (HP:0007431)8.16947219
6Petechiae (HP:0000967)8.06515876
7Abnormal platelet volume (HP:0011876)7.80549474
8Increased IgE level (HP:0003212)7.70229478
9Hypotrichosis (HP:0001006)6.96121194
10Purpura (HP:0000979)6.95478105
11Epistaxis (HP:0000421)6.53156480
12Parakeratosis (HP:0001036)6.13916813
13Lip pit (HP:0100267)6.08355808
14Woolly hair (HP:0002224)6.07839595
15Erythema (HP:0010783)6.03453513
16Erythroderma (HP:0001019)5.86759372
17Right ventricular cardiomyopathy (HP:0011663)5.74592116
18Gingival bleeding (HP:0000225)5.59157531
19Plantar hyperkeratosis (HP:0007556)5.25078589
20Palmoplantar hyperkeratosis (HP:0000972)5.15153226
21Onycholysis (HP:0001806)4.99181097
22Palmar hyperkeratosis (HP:0010765)4.82155714
23Hyperlipoproteinemia (HP:0010980)4.72727990
24Abnormal platelet function (HP:0011869)4.65003878
25Impaired platelet aggregation (HP:0003540)4.65003878
26Abnormality of nail color (HP:0100643)4.52090673
27Abnormality of the axillary hair (HP:0100134)4.37843909
28Abnormality of secondary sexual hair (HP:0009888)4.37843909
29Fragile nails (HP:0001808)4.17588222
30Conjunctival hamartoma (HP:0100780)4.14250929
31Corneal erosion (HP:0200020)4.08700899
32Ectropion (HP:0000656)4.03107127
33Spontaneous hematomas (HP:0007420)3.97726231
34Hypohidrosis (HP:0000966)3.85810123
35Sparse scalp hair (HP:0002209)3.79368366
36Gangrene (HP:0100758)3.70809877
37Popliteal pterygium (HP:0009756)3.69848860
38Acanthocytosis (HP:0001927)3.68670689
39Natal tooth (HP:0000695)3.61935986
40Poikilocytosis (HP:0004447)3.60058422
41Abnormal blistering of the skin (HP:0008066)3.56527545
42Hyporeflexia of lower limbs (HP:0002600)3.46607838
43Eczematoid dermatitis (HP:0000976)3.37139847
44Pruritus (HP:0000989)3.36670676
45Abnormality of cells of the erythroid lineage (HP:0012130)3.31866802
46Acanthosis nigricans (HP:0000956)3.27583621
47Reticulocytopenia (HP:0001896)3.26318077
48Abnormality of the heme biosynthetic pathway (HP:0010472)3.24656776
49Sparse eyelashes (HP:0000653)3.24216788
50Curly hair (HP:0002212)3.22823086
51Advanced eruption of teeth (HP:0006288)3.19252009
52Pili torti (HP:0003777)3.17495758
53Palmoplantar keratoderma (HP:0000982)3.14244155
54Distal lower limb muscle weakness (HP:0009053)3.09299143
55Increased density of long bones (HP:0006392)3.08723405
56Increased IgM level (HP:0003496)3.06774097
57Abnormality of the salivary glands (HP:0010286)3.02312458
58Ventricular tachycardia (HP:0004756)2.92970033
59Conjunctival telangiectasia (HP:0000524)2.92365016
60Nail dystrophy (HP:0008404)2.90968205
61Milia (HP:0001056)2.85951887
62Hypoplastic labia majora (HP:0000059)2.83174599
63Abnormal pupillary function (HP:0007686)2.82694487
64Bruising susceptibility (HP:0000978)2.82176760
65Dyschromatopsia (HP:0007641)2.80480937
66Abnormality of the common coagulation pathway (HP:0010990)2.78482314
67Septate vagina (HP:0001153)2.77368100
68Concave nail (HP:0001598)2.76502292
69Hypophosphatemic rickets (HP:0004912)2.76496540
70Congenital, generalized hypertrichosis (HP:0004540)2.76283284
71Abnormal hemoglobin (HP:0011902)2.73543827
72Thick nail (HP:0001805)2.72715373
73Retrobulbar optic neuritis (HP:0100654)2.69971125
74Optic neuritis (HP:0100653)2.69971125
75Stomatitis (HP:0010280)2.65049643
76Abnormal number of erythroid precursors (HP:0012131)2.60045439
77Brittle hair (HP:0002299)2.56495060
78Dry skin (HP:0000958)2.56183752
79Abnormality of the labia majora (HP:0012881)2.55758022
80Encephalitis (HP:0002383)2.54047342
81Hepatosplenomegaly (HP:0001433)2.51399928
82Keratoconjunctivitis sicca (HP:0001097)2.48326773
83Joint swelling (HP:0001386)2.47099588
84Orchitis (HP:0100796)2.44462557
85Areflexia of lower limbs (HP:0002522)2.44063908
86Abnormality of the vasculature of the conjunctiva (HP:0008054)2.41957461
87Upper limb muscle weakness (HP:0003484)2.36041801
88Arterial thrombosis (HP:0004420)2.35653688
89Hypergammaglobulinemia (HP:0010702)2.34768011
90Macrocytic anemia (HP:0001972)2.33829502
91Severe Myopia (HP:0011003)2.33797673
92Stenosis of the external auditory canal (HP:0000402)2.31188884
93Hamartoma of the eye (HP:0010568)2.28719273
94Keratoconjunctivitis (HP:0001096)2.27729269
95Dehydration (HP:0001944)2.25791075
96Myositis (HP:0100614)2.22538165
97Joint hemorrhage (HP:0005261)2.22246464
98Pterygium (HP:0001059)2.17907997
99Lack of skin elasticity (HP:0100679)2.16572950
100Abnormality of lateral ventricle (HP:0030047)2.14592881
101Anhidrosis (HP:0000970)2.13991194
102Abnormality of the gastric mucosa (HP:0004295)2.11477892
103Oligodontia (HP:0000677)2.11274406
104Abnormality of macrophages (HP:0004311)2.08821253
105Xanthomatosis (HP:0000991)2.03192575
106Ventricular fibrillation (HP:0001663)2.01974474
107Abnormal hair laboratory examination (HP:0003328)2.00813300
108Myocardial infarction (HP:0001658)2.00131708
109Conical tooth (HP:0000698)1.96301443
110Pallor (HP:0000980)1.94527791
111Aplasia involving bones of the extremities (HP:0009825)1.94256413
112Aplasia involving bones of the upper limbs (HP:0009823)1.94256413
113Aplasia of the phalanges of the hand (HP:0009802)1.94256413
114Vertigo (HP:0002321)1.91020941
115Autoimmune hemolytic anemia (HP:0001890)1.90685267
116Ridged nail (HP:0001807)1.88978156
117Villous atrophy (HP:0011473)1.88401907
118Abnormality of small intestinal villus morphology (HP:0011472)1.88401907
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86880972
120Hypoparathyroidism (HP:0000829)1.86555428
121Blepharitis (HP:0000498)1.85302520
122Paralysis (HP:0003470)1.85256456
123Papilledema (HP:0001085)1.83853934
124Abnormality of iron homeostasis (HP:0011031)1.81363597
125Chronic obstructive pulmonary disease (HP:0006510)1.80440688
126Obstructive lung disease (HP:0006536)1.80440688
127Abnormal auditory evoked potentials (HP:0006958)1.79470281
128Atrophic scars (HP:0001075)1.77619795
129Labial hypoplasia (HP:0000066)1.74840175
130Pulmonary embolism (HP:0002204)1.74800174
131Generalized aminoaciduria (HP:0002909)1.71565487
132Thrombophlebitis (HP:0004418)1.69919483
133Rickets (HP:0002748)1.69840104
134Alopecia of scalp (HP:0002293)1.69426770
135Skin pits (HP:0100276)1.67745822
136Pustule (HP:0200039)1.67605039
137Anorexia (HP:0002039)1.66940943
138Hypodontia (HP:0000668)1.66647088
139Papillary thyroid carcinoma (HP:0002895)1.66575518
140Polycythemia (HP:0001901)1.65187888
141Urticaria (HP:0001025)1.63372368
142Male infertility (HP:0003251)1.62212054
143Malignant hyperthermia (HP:0002047)1.62132240
144Increased connective tissue (HP:0009025)1.60867251
145Vasculitis (HP:0002633)1.58261185
146Absent eyebrow (HP:0002223)1.56334629
147Abnormality of the 2nd finger (HP:0004100)1.55281418
148Hypoplastic female external genitalia (HP:0012815)1.54597668
149Ulnar claw (HP:0001178)1.53529952
150IgG deficiency (HP:0004315)1.53351233
151Humeroradial synostosis (HP:0003041)1.52885317
152Synostosis involving the elbow (HP:0003938)1.52885317
153Abnormality of the distal phalanges of the toes (HP:0010182)1.52334388
154Neonatal death (HP:0003811)1.51970153
155Bifid scrotum (HP:0000048)1.51288762
156Skin ulcer (HP:0200042)1.51021739
157Corneal dystrophy (HP:0001131)1.50698802
158Renal cortical cysts (HP:0000803)1.50474491
159Episodic fever (HP:0001954)1.50148823
160Dysautonomia (HP:0002459)1.50125348
161Hypoplasia of dental enamel (HP:0006297)1.49558722
162Fasciculations (HP:0002380)1.49174360
163Abnormality of transition element cation homeostasis (HP:0011030)1.48439789
164Oral leukoplakia (HP:0002745)1.48293889
165Granulocytopenia (HP:0001913)1.48226185
166Increased serum ferritin (HP:0003281)1.47578448
167Slow-growing hair (HP:0002217)1.47371905
168Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.47356628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.45073493
2MST44.71058969
3MAP3K34.25434247
4MAPKAPK34.14104532
5TXK3.61552005
6EIF2AK13.54583737
7BMX3.45088647
8MAP4K13.31566560
9GRK63.07748749
10FER3.05632404
11MAP3K22.78520320
12ZAP702.77083565
13TEC2.72448647
14ARAF2.68218736
15TAOK32.65078280
16BTK2.57552265
17MYLK2.51352381
18PIM22.51032225
19SIK32.48402223
20RPS6KB22.34649170
21MET2.33822671
22TRPM72.31648289
23PTK2B2.08111753
24ERBB32.00430600
25LRRK21.96450066
26FGFR21.82649400
27TESK11.80408257
28BCR1.79988525
29CSF1R1.65815173
30STK241.62451031
31NTRK21.61639768
32STK101.59111564
33MAPKAPK51.56896864
34FES1.54474445
35EPHB21.48554248
36ERN11.46954359
37LATS11.45901288
38EPHA21.45194795
39FGR1.43888035
40GRK11.36557303
41PIK3CG1.25876497
42EPHB11.20528856
43FGFR41.20244737
44LIMK11.18751012
45LMTK21.16595204
46MAP3K141.14863800
47MAP2K61.14030227
48RIPK41.12995433
49DYRK1B1.11303439
50MARK31.08010341
51TGFBR21.05772177
52MAP3K111.04678349
53SIK11.04040736
54TAOK11.03566936
55TTN1.00665905
56LYN0.98299926
57PRPF4B0.98060059
58JAK10.97400257
59PTK60.95667020
60GRK70.95620867
61CSK0.95481637
62IRAK30.94082569
63RIPK10.90410201
64MAPK120.88522441
65MAP3K10.87441793
66EPHA30.86957736
67BLK0.86428149
68TAOK20.84961154
69NEK90.83970754
70TYK20.83868696
71CDK60.82932277
72IRAK10.82348530
73NME20.79289944
74ITK0.79054665
75CDK30.78058736
76PAK10.76318646
77NLK0.73270918
78RET0.73001602
79MAPK150.72166789
80LCK0.71175255
81FGFR30.70978471
82MAPKAPK20.68401260
83PLK20.68044807
84ADRBK20.66801489
85ADRBK10.66766390
86MATK0.63896229
87EEF2K0.63720716
88PRKCQ0.61956339
89MUSK0.61407022
90EPHA40.60869743
91MAP3K120.60592745
92STK40.58064291
93BRAF0.57669647
94EIF2AK20.56278270
95OBSCN0.56258057
96STK30.55134127
97ILK0.53614481
98MAPK110.53363711
99MAP3K70.52994062
100PDK10.52034233
101RPS6KA40.51596707
102JAK30.51403464
103MAP2K20.51383402
104PIM10.51318006
105MAP2K10.50488671
106CDK190.49826842
107MAP2K30.49638581
108FRK0.49178505
109RAF10.48966425
110PKN10.48952415
111IKBKB0.48626298
112TYRO30.48284745
113PAK30.46301349
114GRK50.45502908
115SCYL20.44196886
116FGFR10.43857297
117MAP3K50.43628406
118DAPK30.42016079
119PRKCE0.40039860
120PRKD10.39507609
121CSNK1D0.38972995
122BMPR20.37986275
123TGFBR10.36906857
124DMPK0.36857926
125BMPR1B0.36759821
126PDGFRB0.36747776
127LATS20.36703131
128CASK0.35727966
129ROCK10.34823181
130STK110.32330413
131FYN0.32261177
132PTK20.31364145
133PBK0.31127542
134PRKACG0.30911198
135HCK0.30349566
136ABL10.28942754
137MOS0.28551959
138PDPK10.28379774
139PRKCI0.28191759
140RPS6KA10.27932965
141YES10.27689861
142MAP3K60.27055975
143MAP2K40.27025840
144PRKCD0.26534163
145ROCK20.26497590
146TTK0.26324183
147IKBKE0.25893660
148SYK0.25871928
149TNK20.25536721
150SRC0.25364332
151IGF1R0.24761462
152JAK20.24504021
153ERBB20.24119208
154IRAK40.23972717
155HIPK20.23731389
156TLK10.23095062
157MAPK70.17687695
158SIK20.13651589

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004606.72912867
2Ribosome_Homo sapiens_hsa030104.67138782
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.24865569
4Sphingolipid metabolism_Homo sapiens_hsa006003.61420900
5Fatty acid elongation_Homo sapiens_hsa000623.20907941
6Linoleic acid metabolism_Homo sapiens_hsa005913.19523321
7Arachidonic acid metabolism_Homo sapiens_hsa005903.15624514
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09283624
9Phenylalanine metabolism_Homo sapiens_hsa003602.34778238
10Histidine metabolism_Homo sapiens_hsa003402.32332469
11Hematopoietic cell lineage_Homo sapiens_hsa046402.11213895
12Retinol metabolism_Homo sapiens_hsa008301.87947335
13Ether lipid metabolism_Homo sapiens_hsa005651.85542374
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.75478724
15T cell receptor signaling pathway_Homo sapiens_hsa046601.73759096
16Chemokine signaling pathway_Homo sapiens_hsa040621.72851924
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66719476
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62523402
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51804775
20Nitrogen metabolism_Homo sapiens_hsa009101.49037529
21Primary immunodeficiency_Homo sapiens_hsa053401.43944184
22Chemical carcinogenesis_Homo sapiens_hsa052041.41998264
23B cell receptor signaling pathway_Homo sapiens_hsa046621.39350666
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36597465
25Tyrosine metabolism_Homo sapiens_hsa003501.25816283
26Basal cell carcinoma_Homo sapiens_hsa052171.23701048
27Caffeine metabolism_Homo sapiens_hsa002321.22197223
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19582089
29Shigellosis_Homo sapiens_hsa051311.19063568
30VEGF signaling pathway_Homo sapiens_hsa043701.18882374
31Pancreatic cancer_Homo sapiens_hsa052121.18787749
32Glycerolipid metabolism_Homo sapiens_hsa005611.17502710
33Serotonergic synapse_Homo sapiens_hsa047261.15647267
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14829627
35Adherens junction_Homo sapiens_hsa045201.13832940
36Osteoclast differentiation_Homo sapiens_hsa043801.12950023
37p53 signaling pathway_Homo sapiens_hsa041151.10871964
38Sphingolipid signaling pathway_Homo sapiens_hsa040711.10787247
39Tight junction_Homo sapiens_hsa045301.10518234
40Malaria_Homo sapiens_hsa051441.08211069
41Graft-versus-host disease_Homo sapiens_hsa053321.06957378
42Choline metabolism in cancer_Homo sapiens_hsa052311.05478521
43Axon guidance_Homo sapiens_hsa043601.04108730
44Non-small cell lung cancer_Homo sapiens_hsa052231.03595526
45Staphylococcus aureus infection_Homo sapiens_hsa051501.03556314
46Glutathione metabolism_Homo sapiens_hsa004800.99177244
47Gap junction_Homo sapiens_hsa045400.98984664
48Fat digestion and absorption_Homo sapiens_hsa049750.98250623
49Sulfur metabolism_Homo sapiens_hsa009200.95865523
50Acute myeloid leukemia_Homo sapiens_hsa052210.93377885
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.90586455
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90426335
53Allograft rejection_Homo sapiens_hsa053300.88864056
54Renin secretion_Homo sapiens_hsa049240.87750846
55GnRH signaling pathway_Homo sapiens_hsa049120.87290914
56Autoimmune thyroid disease_Homo sapiens_hsa053200.87028851
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86365982
58beta-Alanine metabolism_Homo sapiens_hsa004100.86289543
59Pancreatic secretion_Homo sapiens_hsa049720.86129424
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.85994773
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85407816
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85072643
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80931930
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80286297
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80064326
66Hippo signaling pathway_Homo sapiens_hsa043900.79940248
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79875615
68Phototransduction_Homo sapiens_hsa047440.77822984
69ABC transporters_Homo sapiens_hsa020100.75290994
70Melanogenesis_Homo sapiens_hsa049160.74227912
71Ras signaling pathway_Homo sapiens_hsa040140.70939138
72Measles_Homo sapiens_hsa051620.70927150
73ECM-receptor interaction_Homo sapiens_hsa045120.69570604
74Apoptosis_Homo sapiens_hsa042100.69357990
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68817588
76Fatty acid biosynthesis_Homo sapiens_hsa000610.67418830
77Bladder cancer_Homo sapiens_hsa052190.66797181
78Starch and sucrose metabolism_Homo sapiens_hsa005000.66567091
79Hedgehog signaling pathway_Homo sapiens_hsa043400.66260660
80Proteoglycans in cancer_Homo sapiens_hsa052050.65707710
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64375260
82Small cell lung cancer_Homo sapiens_hsa052220.62978009
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62934864
84Long-term depression_Homo sapiens_hsa047300.62476318
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62026781
86Endometrial cancer_Homo sapiens_hsa052130.61609959
87Focal adhesion_Homo sapiens_hsa045100.59924732
88Viral carcinogenesis_Homo sapiens_hsa052030.59700173
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.59668461
90TGF-beta signaling pathway_Homo sapiens_hsa043500.58922238
91Alcoholism_Homo sapiens_hsa050340.58396420
92Renal cell carcinoma_Homo sapiens_hsa052110.57010860
93Phagosome_Homo sapiens_hsa041450.55896580
94Ovarian steroidogenesis_Homo sapiens_hsa049130.55579625
95MicroRNAs in cancer_Homo sapiens_hsa052060.55577205
96Pertussis_Homo sapiens_hsa051330.55479160
97Platelet activation_Homo sapiens_hsa046110.54739061
98Amoebiasis_Homo sapiens_hsa051460.53939475
99Olfactory transduction_Homo sapiens_hsa047400.53747352
100Collecting duct acid secretion_Homo sapiens_hsa049660.53558093
101Salivary secretion_Homo sapiens_hsa049700.52101484
102Systemic lupus erythematosus_Homo sapiens_hsa053220.51771267
103Mineral absorption_Homo sapiens_hsa049780.51758290
104Glioma_Homo sapiens_hsa052140.51673200
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51031198
106TNF signaling pathway_Homo sapiens_hsa046680.50425500
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.48532752
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48345485
109Hepatitis C_Homo sapiens_hsa051600.47217070
110Tuberculosis_Homo sapiens_hsa051520.46732177
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.46220141
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45970399
113Notch signaling pathway_Homo sapiens_hsa043300.45560674
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45152053
115Complement and coagulation cascades_Homo sapiens_hsa046100.44888105
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.44829753
117Circadian entrainment_Homo sapiens_hsa047130.44646370
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.44306192
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43920083
120Hepatitis B_Homo sapiens_hsa051610.42444211
121Viral myocarditis_Homo sapiens_hsa054160.42360363
122Chronic myeloid leukemia_Homo sapiens_hsa052200.42346483
123Gastric acid secretion_Homo sapiens_hsa049710.39433078
124Oxidative phosphorylation_Homo sapiens_hsa001900.39260438
125Rap1 signaling pathway_Homo sapiens_hsa040150.38058331
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.36752274
127Steroid biosynthesis_Homo sapiens_hsa001000.36357879
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35070506
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34779307
130Melanoma_Homo sapiens_hsa052180.34050837
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.33677236
132Folate biosynthesis_Homo sapiens_hsa007900.32226852
133Wnt signaling pathway_Homo sapiens_hsa043100.30306600
134Alzheimers disease_Homo sapiens_hsa050100.28284937
135Calcium signaling pathway_Homo sapiens_hsa040200.27505226
136Toxoplasmosis_Homo sapiens_hsa051450.26610827
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25806752
138Salmonella infection_Homo sapiens_hsa051320.24970907
139Fatty acid degradation_Homo sapiens_hsa000710.24259829
140Oxytocin signaling pathway_Homo sapiens_hsa049210.23383786
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20564667
142Endocytosis_Homo sapiens_hsa041440.20375111
143Vibrio cholerae infection_Homo sapiens_hsa051100.19922305
144Thyroid cancer_Homo sapiens_hsa052160.19554019
145Glutamatergic synapse_Homo sapiens_hsa047240.19330905
146MAPK signaling pathway_Homo sapiens_hsa040100.18933367
147Dorso-ventral axis formation_Homo sapiens_hsa043200.17661904
148Fatty acid metabolism_Homo sapiens_hsa012120.17633624
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.17336735
150ErbB signaling pathway_Homo sapiens_hsa040120.15828746
151Protein digestion and absorption_Homo sapiens_hsa049740.15133845
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14422581
153PPAR signaling pathway_Homo sapiens_hsa033200.13648913

Most similar genes based on co-expression Upload to Enrichr

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