THEM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)7.72690977
2transcription from mitochondrial promoter (GO:0006390)7.50818359
3embryonic process involved in female pregnancy (GO:0060136)7.09006552
4positive regulation of protein homooligomerization (GO:0032464)6.55973795
5replication fork processing (GO:0031297)6.36166268
6establishment of apical/basal cell polarity (GO:0035089)5.94935977
7regulation of protein homooligomerization (GO:0032462)5.88281957
8regulation of integrin activation (GO:0033623)5.72836723
9oxidative demethylation (GO:0070989)5.69036168
10mitotic G1 DNA damage checkpoint (GO:0031571)5.63124285
11establishment or maintenance of monopolar cell polarity (GO:0061339)5.26123255
12establishment of monopolar cell polarity (GO:0061162)5.26123255
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.11989967
14GDP-mannose metabolic process (GO:0019673)5.01992812
15G1 DNA damage checkpoint (GO:0044783)4.94242132
16mitotic G1/S transition checkpoint (GO:0044819)4.92458367
17DNA deamination (GO:0045006)4.90045744
18negative regulation of protein oligomerization (GO:0032460)4.83784916
19Golgi transport vesicle coating (GO:0048200)4.80733542
20COPI coating of Golgi vesicle (GO:0048205)4.80733542
21negative regulation of cell size (GO:0045792)4.68161973
22mitochondrial DNA metabolic process (GO:0032042)4.64426169
23cellular response to ATP (GO:0071318)4.58639316
24negative regulation of JAK-STAT cascade (GO:0046426)4.57475847
25negative regulation of Ras GTPase activity (GO:0034261)4.48869207
26protein retention in ER lumen (GO:0006621)4.43213716
27regulation of translational fidelity (GO:0006450)4.40915081
28protein localization to endosome (GO:0036010)4.39721934
29negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.36397862
30glutamine family amino acid biosynthetic process (GO:0009084)4.35261332
31regulation of mammary gland epithelial cell proliferation (GO:0033599)4.34757999
32somatic diversification of immune receptors via somatic mutation (GO:0002566)4.31903813
33somatic hypermutation of immunoglobulin genes (GO:0016446)4.31903813
34DNA strand renaturation (GO:0000733)4.31611460
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.30902153
36L-phenylalanine metabolic process (GO:0006558)4.30902153
37signal complex assembly (GO:0007172)4.28732667
38embryonic placenta development (GO:0001892)4.25581628
39spliceosomal tri-snRNP complex assembly (GO:0000244)4.16281517
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.02577890
41poly(A)+ mRNA export from nucleus (GO:0016973)3.94760419
42regulation of protein oligomerization (GO:0032459)3.91949767
43neuromuscular process controlling posture (GO:0050884)3.89619657
44regulation of cAMP-dependent protein kinase activity (GO:2000479)3.87037461
45protein maturation by protein folding (GO:0022417)3.86665592
46negative regulation of cell cycle arrest (GO:0071157)3.83928199
47desmosome organization (GO:0002934)3.82944409
48mRNA cleavage (GO:0006379)3.82868751
49folic acid metabolic process (GO:0046655)3.81437901
50urea cycle (GO:0000050)3.81184411
51amyloid precursor protein catabolic process (GO:0042987)3.79718691
52histone H4-K12 acetylation (GO:0043983)3.78317578
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.77204881
54NADH metabolic process (GO:0006734)3.72416215
55positive regulation by host of viral transcription (GO:0043923)3.67436777
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67208280
57regulation of cholesterol biosynthetic process (GO:0045540)3.66725052
58regulation of early endosome to late endosome transport (GO:2000641)3.64653351
59synaptic vesicle endocytosis (GO:0048488)3.63385936
60positive regulation of protein oligomerization (GO:0032461)3.60361314
61negative regulation of fatty acid biosynthetic process (GO:0045717)3.59554114
62glucose catabolic process (GO:0006007)3.59200021
63urea metabolic process (GO:0019627)3.58949363
64retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.57763644
65hypotonic response (GO:0006971)3.57741589
66apoptotic process involved in morphogenesis (GO:0060561)3.56684326
67cellular response to zinc ion (GO:0071294)3.56463349
68peptidyl-arginine omega-N-methylation (GO:0035247)3.56367517
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.54633301
70labyrinthine layer development (GO:0060711)3.54322748
71viral mRNA export from host cell nucleus (GO:0046784)3.49199967
72embryonic camera-type eye development (GO:0031076)3.45008077
73activation of Rac GTPase activity (GO:0032863)3.43313817
74pentose-phosphate shunt (GO:0006098)3.40093160
75glucose 6-phosphate metabolic process (GO:0051156)3.38585257
76negative regulation of heart rate (GO:0010459)3.38355165
77maternal placenta development (GO:0001893)3.36153587
78positive regulation of developmental pigmentation (GO:0048087)3.35891919
79cell migration in hindbrain (GO:0021535)3.35324301
80glial cell migration (GO:0008347)3.33857791
81convergent extension (GO:0060026)3.31224880
82regulation of cell size (GO:0008361)3.29864806
83regulation of fatty acid beta-oxidation (GO:0031998)3.25332471
84base-excision repair (GO:0006284)3.24222199
85positive regulation of Cdc42 GTPase activity (GO:0043089)3.23252200
86pentose metabolic process (GO:0019321)3.22678773
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21354236
88positive regulation of mitotic sister chromatid separation (GO:1901970)3.20654894
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20654894
90positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20654894
91dosage compensation (GO:0007549)3.19105683
92trophectodermal cell differentiation (GO:0001829)3.18598878
93nitrogen cycle metabolic process (GO:0071941)3.17687103
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.13858392
95L-phenylalanine catabolic process (GO:0006559)3.13858392
96regulation of RNA export from nucleus (GO:0046831)3.13517390
97mitochondrion transport along microtubule (GO:0047497)3.12819575
98establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.12819575
99nucleobase-containing small molecule interconversion (GO:0015949)3.12469893
100biotin metabolic process (GO:0006768)3.12273575
101DNA integration (GO:0015074)3.11999064
102regulation of mitochondrial depolarization (GO:0051900)3.11255407
103monosaccharide biosynthetic process (GO:0046364)3.09100972
104double-strand break repair via nonhomologous end joining (GO:0006303)3.08713931
105non-recombinational repair (GO:0000726)3.08713931
106positive regulation of keratinocyte differentiation (GO:0045618)3.08386525
107sulfur amino acid catabolic process (GO:0000098)3.07153715
108face development (GO:0060324)3.05116456
109negative regulation of mRNA processing (GO:0050686)3.04938766
110respiratory system process (GO:0003016)3.03896687
111neuromuscular process controlling balance (GO:0050885)3.01988737
112oxaloacetate metabolic process (GO:0006107)3.01459041
113regulation of response to reactive oxygen species (GO:1901031)3.00143867
114gluconeogenesis (GO:0006094)2.99069445
115positive regulation of receptor recycling (GO:0001921)2.97547124
116regulation of cholesterol metabolic process (GO:0090181)2.94073098
117membrane tubulation (GO:0097320)2.93938647
118regulation of cilium movement (GO:0003352)2.93679342
119determination of adult lifespan (GO:0008340)2.93223142
120positive regulation of dendritic spine morphogenesis (GO:0061003)2.92866323
121protein targeting to lysosome (GO:0006622)2.92314091
122establishment of protein localization to vacuole (GO:0072666)2.92314091
123protein targeting to vacuole (GO:0006623)2.92314091
124hexose biosynthetic process (GO:0019319)2.90406691
125N-glycan processing (GO:0006491)2.90404293
126amyloid precursor protein metabolic process (GO:0042982)2.89380806
127nodal signaling pathway (GO:0038092)2.89210903
128regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.89174421
129formation of translation preinitiation complex (GO:0001731)2.88694385
130auditory receptor cell stereocilium organization (GO:0060088)2.88548707
131rRNA transcription (GO:0009303)2.88371372
132negative regulation of adherens junction organization (GO:1903392)2.88141352
133negative regulation of focal adhesion assembly (GO:0051895)2.88141352
134negative regulation of cell junction assembly (GO:1901889)2.88141352
135mRNA polyadenylation (GO:0006378)2.88120030
136regulation of sister chromatid cohesion (GO:0007063)2.88107902
137intracellular estrogen receptor signaling pathway (GO:0030520)2.88010108
138mitotic nuclear envelope reassembly (GO:0007084)2.87867481
139nuclear envelope reassembly (GO:0031468)2.87867481
140response to food (GO:0032094)2.87637249
141mitochondrial RNA metabolic process (GO:0000959)2.84669901
142NADPH regeneration (GO:0006740)2.84621009
143positive regulation of DNA repair (GO:0045739)2.84487317
144anatomical structure regression (GO:0060033)2.84050873
145focal adhesion assembly (GO:0048041)2.83435046
146cell-substrate adherens junction assembly (GO:0007045)2.83435046
147regulation of membrane depolarization (GO:0003254)2.83034036
148guanosine-containing compound biosynthetic process (GO:1901070)2.79984453
149positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.70701244
150purine ribonucleotide transport (GO:0015868)2.69843165
151UV protection (GO:0009650)2.67740592
152purine nucleotide transport (GO:0015865)2.66559678
153protein carboxylation (GO:0018214)2.65803547
154peptidyl-glutamic acid carboxylation (GO:0017187)2.65803547
1554-hydroxyproline metabolic process (GO:0019471)2.63759068
156peptidyl-arginine methylation (GO:0018216)2.63412348
157peptidyl-arginine N-methylation (GO:0035246)2.63412348
158regulation of glucose import in response to insulin stimulus (GO:2001273)2.62570843
159positive regulation of cellular amine metabolic process (GO:0033240)2.60609587
160adherens junction assembly (GO:0034333)2.58790899
161endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.58215013
162adenine nucleotide transport (GO:0051503)2.57885645
163mitochondrial fusion (GO:0008053)2.57860947
164regulation of water loss via skin (GO:0033561)2.57784744
165positive regulation of triglyceride lipase activity (GO:0061365)2.56842344
166positive regulation of lipoprotein lipase activity (GO:0051006)2.56842344
167UTP biosynthetic process (GO:0006228)2.55002173
168mammary gland epithelial cell differentiation (GO:0060644)2.53808937
169L-serine metabolic process (GO:0006563)2.53675196
170positive regulation of epidermal cell differentiation (GO:0045606)2.52113039
171DNA unwinding involved in DNA replication (GO:0006268)2.51443637
172branching involved in mammary gland duct morphogenesis (GO:0060444)2.51320569
173hepatocyte apoptotic process (GO:0097284)2.51062689
174negative regulation of fatty acid transport (GO:2000192)2.49992041
175regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.48085523
176snRNA metabolic process (GO:0016073)2.48077631
177histone arginine methylation (GO:0034969)2.47888717
178modulation by virus of host morphology or physiology (GO:0019048)2.45232828
179negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.44834705
180negative regulation of viral release from host cell (GO:1902187)2.43743044
181negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.43165979
182basement membrane organization (GO:0071711)2.42104309
183fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.40086064
184regulation of mitochondrial translation (GO:0070129)2.37793636
185regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.37231374
186regulation of cholesterol homeostasis (GO:2000188)2.36899939
187post-embryonic morphogenesis (GO:0009886)2.34215398
188glutathione biosynthetic process (GO:0006750)2.33395974
189pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.32671681
190mitotic chromosome condensation (GO:0007076)2.32664834
191folic acid-containing compound metabolic process (GO:0006760)2.32485165
192proline biosynthetic process (GO:0006561)10.3697753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.44925103
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.05059955
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97879881
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.86430604
5LXR_22292898_ChIP-Seq_THP-1_Human2.76639662
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.76344762
7VDR_21846776_ChIP-Seq_THP-1_Human2.74218205
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.73467466
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64153644
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.52305628
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.52305628
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.52305628
13ERG_21242973_ChIP-ChIP_JURKAT_Human2.52082541
14E2F7_22180533_ChIP-Seq_HELA_Human2.48704133
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.37439255
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.26375255
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18908139
18SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.15645210
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.14399395
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13895807
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.12605950
22MYC_22102868_ChIP-Seq_BL_Human2.08488517
23POU5F1_16518401_ChIP-PET_MESCs_Mouse2.07915890
24KDM2B_26808549_Chip-Seq_DND41_Human2.07862276
25ZNF263_19887448_ChIP-Seq_K562_Human2.06727514
26KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.06334225
27NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03072807
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00132690
29ZFP281_27345836_Chip-Seq_ESCs_Mouse2.00095952
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95328138
31CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.94568691
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91914299
33RACK7_27058665_Chip-Seq_MCF-7_Human1.86833351
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.85728458
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.84200503
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83463282
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83313666
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79545890
39PU.1_20513432_ChIP-Seq_Bcells_Mouse1.78275625
40KDM2B_26808549_Chip-Seq_K562_Human1.75981352
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72101372
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66389643
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65757191
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.65480976
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64301231
46XRN2_22483619_ChIP-Seq_HELA_Human1.62158526
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60785474
48NANOG_21062744_ChIP-ChIP_HESCs_Human1.60270210
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59501399
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59306212
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.54809034
52NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53653078
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52099605
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51666632
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50274260
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49773131
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47696176
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47475899
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.45265237
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45244929
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43821524
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42202162
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41578019
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.41555976
65CTCF_21964334_ChIP-Seq_BJAB-B_Human1.40968043
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.40351688
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.40085825
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38340901
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38235423
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37860296
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.37851153
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37106519
73SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.36118132
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35939821
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35485082
76TCF7_22412390_ChIP-Seq_EML_Mouse1.35366511
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.35272579
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.34907153
79ETS1_21867929_ChIP-Seq_TH2_Mouse1.33907165
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33397461
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33204171
82ATF3_27146783_Chip-Seq_COLON_Human1.31290223
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30893606
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29947910
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.28523276
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28488239
87POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.28405047
88P68_20966046_ChIP-Seq_HELA_Human1.27984987
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27896475
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26757558
91CTCF_27219007_Chip-Seq_Bcells_Human1.26448170
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26185201
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25433941
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25208009
95MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24215447
96CREB1_26743006_Chip-Seq_LNCaP_Human1.23611907
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23399787
98GABP_19822575_ChIP-Seq_HepG2_Human1.23337518
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22378593
100BCOR_27268052_Chip-Seq_Bcells_Human1.22215989
101DCP1A_22483619_ChIP-Seq_HELA_Human1.22167597
102SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21485004
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21124292
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20427168
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20347743
106MYC_18555785_ChIP-Seq_MESCs_Mouse1.19753776
107PHF8_20622854_ChIP-Seq_HELA_Human1.18861988
108TET1_21490601_ChIP-Seq_MESCs_Mouse1.18382264
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18164031
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17428827
111E2F1_20622854_ChIP-Seq_HELA_Human1.17189478
112SMC4_20622854_ChIP-Seq_HELA_Human1.17046640
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16327618
114RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16216010
115CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16066254
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15911092
117CTCF_26484167_Chip-Seq_Bcells_Mouse1.14900049
118RARB_24833708_ChIP-Seq_LIVER_Mouse1.14331710
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14254232
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13696870
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13462447
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.12572211
123KDM5A_27292631_Chip-Seq_BREAST_Human1.12502010
124NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12303043
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12274609
126TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11132692
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10547387
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10316574
129ELF1_20517297_ChIP-Seq_JURKAT_Human1.09464161
130SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09142735
131RARA_24833708_ChIP-Seq_LIVER_Mouse1.08776573
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07715164
133FOXP1_21924763_ChIP-Seq_HESCs_Human1.07588106
134SA1_27219007_Chip-Seq_Bcells_Human1.07399881
135E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05926468
136MAF_26560356_Chip-Seq_TH2_Human1.05326965
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05316365
138SPI1_26923725_Chip-Seq_HPCs_Mouse1.03381716
139E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02951219
140DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02808037
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02641432
142STAT1_20625510_ChIP-Seq_HELA_Human1.02525627
143BCL6_27268052_Chip-Seq_Bcells_Human1.01938335
144TP53_20018659_ChIP-ChIP_R1E_Mouse1.00864179
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99683558
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99646377
147MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99517485
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.99384091
149REST_18959480_ChIP-ChIP_MESCs_Mouse0.98904736
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.98716581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.95358166
2MP0009278_abnormal_bone_marrow4.42608259
3MP0005451_abnormal_body_composition4.20120369
4MP0005171_absent_coat_pigmentation3.97610102
5MP0004233_abnormal_muscle_weight3.84158703
6MP0010030_abnormal_orbit_morphology3.61195311
7MP0010234_abnormal_vibrissa_follicle3.43027181
8MP0004185_abnormal_adipocyte_glucose3.02227222
9MP0004859_abnormal_synaptic_plasticity2.97549783
10MP0002009_preneoplasia2.96458762
11MP0005360_urolithiasis2.81810431
12MP0003283_abnormal_digestive_organ2.62648360
13MP0005501_abnormal_skin_physiology2.53066965
14MP0003191_abnormal_cellular_cholesterol2.44213492
15MP0008995_early_reproductive_senescence2.26176466
16MP0004264_abnormal_extraembryonic_tissu2.17412942
17MP0008260_abnormal_autophagy2.09270565
18MP0003172_abnormal_lysosome_physiology2.07849144
19MP0005670_abnormal_white_adipose2.07563804
20MP0009840_abnormal_foam_cell2.07192651
21MP0003123_paternal_imprinting2.06966395
22MP0006072_abnormal_retinal_apoptosis2.05606212
23MP0002653_abnormal_ependyma_morphology2.01607781
24MP0003890_abnormal_embryonic-extraembry1.92472554
25MP0005666_abnormal_adipose_tissue1.91530793
26MP0005397_hematopoietic_system_phenotyp1.91109647
27MP0001545_abnormal_hematopoietic_system1.91109647
28MP0000003_abnormal_adipose_tissue1.86217995
29MP0005076_abnormal_cell_differentiation1.81593599
30MP0005083_abnormal_biliary_tract1.80211733
31MP0000678_abnormal_parathyroid_gland1.77931582
32MP0009046_muscle_twitch1.76926158
33MP0002098_abnormal_vibrissa_morphology1.72518602
34MP0005174_abnormal_tail_pigmentation1.71797508
35MP0004133_heterotaxia1.71629994
36MP0003453_abnormal_keratinocyte_physiol1.68911355
37MP0002733_abnormal_thermal_nociception1.68060454
38MP0010352_gastrointestinal_tract_polyps1.67798382
39MP0005365_abnormal_bile_salt1.67744207
40MP0000566_synostosis1.67001906
41MP0005375_adipose_tissue_phenotype1.65991508
42MP0003119_abnormal_digestive_system1.64851791
43MP0002269_muscular_atrophy1.64389577
44MP0008877_abnormal_DNA_methylation1.62745323
45MP0002139_abnormal_hepatobiliary_system1.59308890
46MP0001661_extended_life_span1.57094297
47MP0004381_abnormal_hair_follicle1.56262106
48MP0004782_abnormal_surfactant_physiolog1.54240893
49MP0001881_abnormal_mammary_gland1.53244355
50MP0003693_abnormal_embryo_hatching1.51441692
51MP0001873_stomach_inflammation1.50882639
52MP0002063_abnormal_learning/memory/cond1.50796910
53MP0002249_abnormal_larynx_morphology1.48808619
54MP0003806_abnormal_nucleotide_metabolis1.48409099
55MP0001970_abnormal_pain_threshold1.47004383
56MP0010094_abnormal_chromosome_stability1.44263281
57MP0002084_abnormal_developmental_patter1.43131542
58MP0003045_fibrosis1.42352698
59MP0005058_abnormal_lysosome_morphology1.41963428
60MP0002089_abnormal_postnatal_growth/wei1.41611651
61MP0003635_abnormal_synaptic_transmissio1.41366744
62MP0000537_abnormal_urethra_morphology1.38520043
63MP0002086_abnormal_extraembryonic_tissu1.37607694
64MP0009780_abnormal_chondrocyte_physiolo1.36657596
65MP0002572_abnormal_emotion/affect_behav1.36575817
66MP0008875_abnormal_xenobiotic_pharmacok1.36292390
67MP0002282_abnormal_trachea_morphology1.34569156
68MP0000467_abnormal_esophagus_morphology1.32700103
69MP0000955_abnormal_spinal_cord1.31880780
70MP0001666_abnormal_nutrient_absorption1.31101113
71MP0003786_premature_aging1.30343342
72MP0000579_abnormal_nail_morphology1.30208977
73MP0001849_ear_inflammation1.29649516
74MP0000639_abnormal_adrenal_gland1.29470497
75MP0002064_seizures1.27372927
76MP0001346_abnormal_lacrimal_gland1.27159282
77MP0004811_abnormal_neuron_physiology1.26334730
78MP0004142_abnormal_muscle_tone1.24549865
79MP0005409_darkened_coat_color1.23378532
80MP0001697_abnormal_embryo_size1.20132740
81MP0004197_abnormal_fetal_growth/weight/1.19961802
82MP0003705_abnormal_hypodermis_morpholog1.18705548
83MP0005645_abnormal_hypothalamus_physiol1.18612597
84MP0002822_catalepsy1.17085980
85MP0002085_abnormal_embryonic_tissue1.15137055
86MP0000858_altered_metastatic_potential1.15107099
87MP0001216_abnormal_epidermal_layer1.14340184
88MP0003566_abnormal_cell_adhesion1.13431026
89MP0000627_abnormal_mammary_gland1.13155795
90MP0000609_abnormal_liver_physiology1.11022315
91MP0001340_abnormal_eyelid_morphology1.10819208
92MP0009931_abnormal_skin_appearance1.10620484
93MP0000751_myopathy1.10393105
94MP0009333_abnormal_splenocyte_physiolog1.08404014
95MP0009672_abnormal_birth_weight1.08340111
96MP0001293_anophthalmia1.08297072
97MP0003137_abnormal_impulse_conducting1.07828252
98MP0003633_abnormal_nervous_system1.06564065
99MP0000470_abnormal_stomach_morphology1.06261880
100MP0000015_abnormal_ear_pigmentation1.05941082
101MP0004957_abnormal_blastocyst_morpholog1.04302250
102MP0003075_altered_response_to1.03478817
103MP0000371_diluted_coat_color1.03134412
104MP0008874_decreased_physiological_sensi1.03054527
105MP0002796_impaired_skin_barrier1.02555750
106MP0000377_abnormal_hair_follicle1.02102128
107MP0001664_abnormal_digestion0.97440683
108MP0000681_abnormal_thyroid_gland0.96633599
109MP0006036_abnormal_mitochondrial_physio0.96262021
110MP0010771_integument_phenotype0.95908066
111MP0001348_abnormal_lacrimal_gland0.95672138
112MP0008569_lethality_at_weaning0.94968514
113MP0009643_abnormal_urine_homeostasis0.92478227
114MP0003656_abnormal_erythrocyte_physiolo0.91947518
115MP0003315_abnormal_perineum_morphology0.90830174
116MP0000538_abnormal_urinary_bladder0.88288863
117MP0002060_abnormal_skin_morphology0.87794709
118MP0005332_abnormal_amino_acid0.87767343
119MP0002118_abnormal_lipid_homeostasis0.87369300
120MP0002066_abnormal_motor_capabilities/c0.86717495
121MP0008932_abnormal_embryonic_tissue0.86179080
122MP0000750_abnormal_muscle_regeneration0.86098870
123MP0005330_cardiomyopathy0.85541661
124MP0001672_abnormal_embryogenesis/_devel0.84705197
125MP0005380_embryogenesis_phenotype0.84705197
126MP0000462_abnormal_digestive_system0.83734216
127MP0003077_abnormal_cell_cycle0.83278458
128MP0001730_embryonic_growth_arrest0.82848870
129MP0005623_abnormal_meninges_morphology0.82642917
130MP0000490_abnormal_crypts_of0.80139222
131MP0005220_abnormal_exocrine_pancreas0.79207344
132MP0003111_abnormal_nucleus_morphology0.78970606
133MP0002272_abnormal_nervous_system0.78912230
134MP0005075_abnormal_melanosome_morpholog0.78613339
135MP0009115_abnormal_fat_cell0.78587813
136MP0010329_abnormal_lipoprotein_level0.77995947
137MP0001727_abnormal_embryo_implantation0.77630902
138MP0002877_abnormal_melanocyte_morpholog0.77231556
139MP0003634_abnormal_glial_cell0.76774527
140MP0002111_abnormal_tail_morphology0.76755576
141MP0002080_prenatal_lethality0.76351795
142MP0000598_abnormal_liver_morphology0.76019190
143MP0000685_abnormal_immune_system0.75222425
144MP0005621_abnormal_cell_physiology0.75098094
145MP0001968_abnormal_touch/_nociception0.74581012
146MP0002114_abnormal_axial_skeleton0.74489400
147MP0003763_abnormal_thymus_physiology0.74408215
148MP0003329_amyloid_beta_deposits0.74164409
149MP0005410_abnormal_fertilization0.73373535
150MP0009745_abnormal_behavioral_response0.73285149
151MP0000350_abnormal_cell_proliferation0.73015887
152MP0004858_abnormal_nervous_system0.72262273
153MP0010630_abnormal_cardiac_muscle0.72196715
154MP0002019_abnormal_tumor_incidence0.72021726
155MP0002882_abnormal_neuron_morphology0.71838148
156MP0003631_nervous_system_phenotype0.71081996
157MP0005085_abnormal_gallbladder_physiolo0.70981421
158MP0010768_mortality/aging0.70625994
159MP0005248_abnormal_Harderian_gland0.70398447
160MP0002075_abnormal_coat/hair_pigmentati0.70220645
161MP0005584_abnormal_enzyme/coenzyme_acti0.69132199
162MP0005408_hypopigmentation0.68954119
163MP0003183_abnormal_peptide_metabolism0.68895806
164MP0002970_abnormal_white_adipose0.68497064
165MP0000313_abnormal_cell_death0.68081646
166MP0008770_decreased_survivor_rate0.67721523
167MP0002751_abnormal_autonomic_nervous0.67185717
168MP0005266_abnormal_metabolism0.67110628
169MP0000747_muscle_weakness0.66774776
170MP0010769_abnormal_survival0.66339799
171MP0003879_abnormal_hair_cell0.66257008
172MP0001764_abnormal_homeostasis0.64598626

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)6.20298728
2Rib fusion (HP:0000902)4.87807375
3Concave nail (HP:0001598)4.67252049
4Turricephaly (HP:0000262)4.55614334
5Pustule (HP:0200039)4.40049383
6Facial hemangioma (HP:0000329)4.31742160
7Deep venous thrombosis (HP:0002625)4.27618182
8Ulnar bowing (HP:0003031)4.21526118
9Rectovaginal fistula (HP:0000143)4.06776182
10Rectal fistula (HP:0100590)4.06776182
11Increased IgM level (HP:0003496)4.02149903
12Male infertility (HP:0003251)3.84095961
13Poikiloderma (HP:0001029)3.79914716
14Alopecia of scalp (HP:0002293)3.75990941
15Hypochromic microcytic anemia (HP:0004840)3.75843422
16Intestinal fistula (HP:0100819)3.74264465
17Vaginal fistula (HP:0004320)3.72241942
18Abnormal hemoglobin (HP:0011902)3.69294285
19Myokymia (HP:0002411)3.45890637
20Orthostatic hypotension (HP:0001278)3.45406900
21Coronal craniosynostosis (HP:0004440)3.39379086
22J-shaped sella turcica (HP:0002680)3.37669743
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.36660953
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.35342242
25Basal cell carcinoma (HP:0002671)3.32584391
26Hyperacusis (HP:0010780)3.31903778
27Congenital hip dislocation (HP:0001374)3.31718745
28Testicular atrophy (HP:0000029)3.30897440
29Short humerus (HP:0005792)3.26335432
30Abnormality of the lower motor neuron (HP:0002366)3.22849721
31Short chin (HP:0000331)3.21682184
32Progressive muscle weakness (HP:0003323)3.19845110
33Septate vagina (HP:0001153)3.18852409
34Ragged-red muscle fibers (HP:0003200)3.18491832
35Dysautonomia (HP:0002459)3.18361273
36Distal lower limb muscle weakness (HP:0009053)3.16636263
37Anteriorly placed anus (HP:0001545)3.14894493
38Hemorrhage of the eye (HP:0011885)3.13900868
39Abnormal gallbladder physiology (HP:0012438)3.13770735
40Cholecystitis (HP:0001082)3.13770735
41Tongue fasciculations (HP:0001308)3.08916616
42Aplasia/hypoplasia of the humerus (HP:0006507)3.01124241
43Hypercortisolism (HP:0001578)2.96214524
44Alacrima (HP:0000522)2.95127477
45Vertebral compression fractures (HP:0002953)2.92509939
46Muscle fibrillation (HP:0010546)2.92426221
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.91026177
48Mucopolysacchariduria (HP:0008155)2.90353706
49Urinary glycosaminoglycan excretion (HP:0003541)2.90353706
50Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.87404031
51Vertebral hypoplasia (HP:0008417)2.87404031
52Micronodular cirrhosis (HP:0001413)2.86608848
53Abnormality of the aortic arch (HP:0012303)2.86524290
54Diaphragmatic weakness (HP:0009113)2.85177126
55Premature skin wrinkling (HP:0100678)2.81466425
56Achilles tendon contracture (HP:0001771)2.81120486
57Abnormality of the Achilles tendon (HP:0005109)2.78523462
58Squamous cell carcinoma (HP:0002860)2.76799095
59Asymmetry of the thorax (HP:0001555)2.74780647
60Clumsiness (HP:0002312)2.72890378
61Dysostosis multiplex (HP:0000943)2.70084564
62Large for gestational age (HP:0001520)2.70017737
63Cerebral aneurysm (HP:0004944)2.68702470
64Growth hormone excess (HP:0000845)2.68174163
65Abnormality of polysaccharide metabolism (HP:0011012)2.61449304
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61449304
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61449304
68Broad alveolar ridges (HP:0000187)2.54837593
69Hypochromic anemia (HP:0001931)2.53013992
70Hamartoma (HP:0010566)2.52442024
71Hypotrichosis (HP:0001006)2.51030103
72Abnormality of male internal genitalia (HP:0000022)2.47941223
73Atonic seizures (HP:0010819)2.44653225
74Intestinal atresia (HP:0011100)2.44017097
75Absent thumb (HP:0009777)2.43148029
76Thin bony cortex (HP:0002753)2.42798289
77Flat acetabular roof (HP:0003180)2.41000991
78Polycythemia (HP:0001901)2.39924626
79Stridor (HP:0010307)2.37264659
80Hypotelorism (HP:0000601)2.36902587
81Hyperammonemia (HP:0001987)2.36070068
82Abnormality of the umbilical cord (HP:0010881)2.35425574
83Bowed forearm bones (HP:0003956)2.34976962
84Bowing of the arm (HP:0006488)2.34976962
85Broad face (HP:0000283)2.34546815
86Pancreatic islet-cell hyperplasia (HP:0004510)2.33843984
87Back pain (HP:0003418)2.31529673
88Hypokinesia (HP:0002375)2.30893442
89Albinism (HP:0001022)2.30863261
90Cholelithiasis (HP:0001081)2.28772853
91Reticulocytosis (HP:0001923)2.28680094
92Abdominal distention (HP:0003270)2.28651092
93Myopathic facies (HP:0002058)2.28136313
94Hyperparathyroidism (HP:0000843)2.27285432
95Increased CSF protein (HP:0002922)2.24530222
96Abnormality of the distal phalanges of the toes (HP:0010182)2.24482096
97Bulbar palsy (HP:0001283)2.22874959
98Absent radius (HP:0003974)2.22327656
99Microretrognathia (HP:0000308)2.22255692
100Asymmetric septal hypertrophy (HP:0001670)2.21485957
101Split hand (HP:0001171)2.19331310
102Acanthosis nigricans (HP:0000956)2.19300752
103Narrow nasal bridge (HP:0000446)2.18629499
104Abnormality of the astrocytes (HP:0100707)2.17836457
105Astrocytoma (HP:0009592)2.17836457
106Joint stiffness (HP:0001387)2.16024897
107Seborrheic dermatitis (HP:0001051)2.14937183
108Decreased lacrimation (HP:0000633)2.14405241
109Distal upper limb amyotrophy (HP:0007149)2.14390660
110Upper limb amyotrophy (HP:0009129)2.14390660
111Popliteal pterygium (HP:0009756)2.13287935
112Fetal akinesia sequence (HP:0001989)2.13095727
113Increased neuronal autofluorescent lipopigment (HP:0002074)2.12835916
114Choanal stenosis (HP:0000452)2.12038260
115Volvulus (HP:0002580)2.10794366
116Vertebral fusion (HP:0002948)2.10544077
117Microvesicular hepatic steatosis (HP:0001414)2.09838596
118Absent forearm bone (HP:0003953)2.09775418
119Aplasia involving forearm bones (HP:0009822)2.09775418
120Abnormality of the labia minora (HP:0012880)2.09525424
121Aplasia of the musculature (HP:0100854)2.09465482
122Bifid uvula (HP:0000193)2.09102185
123Hyperthyroidism (HP:0000836)2.06438915
124Distal lower limb amyotrophy (HP:0008944)2.03812642
125Pili torti (HP:0003777)2.03163501
126Thickened helices (HP:0000391)2.02456590
127Spinal cord compression (HP:0002176)2.00590540
128Diminished movement (HP:0002374)2.00266782
129Increased muscle lipid content (HP:0009058)1.96324104
130Lower limb hyperreflexia (HP:0002395)1.95684699
131Broad distal phalanx of finger (HP:0009836)1.95371395
132Prolonged neonatal jaundice (HP:0006579)1.95039319
133Abnormal hair laboratory examination (HP:0003328)1.93629060
134Paraparesis (HP:0002385)1.92769324
135Spastic paraparesis (HP:0002313)1.91695551
136Exercise-induced myalgia (HP:0003738)1.91010267
137IgA deficiency (HP:0002720)1.89312074
138Prolonged partial thromboplastin time (HP:0003645)1.89245552
139Hypoparathyroidism (HP:0000829)1.88787817
140Hypertriglyceridemia (HP:0002155)1.88296925
141Abnormal gallbladder morphology (HP:0012437)1.87202904
142Increased cerebral lipofuscin (HP:0011813)1.86465450
143Rough bone trabeculation (HP:0100670)1.86334483
144Abnormality of the thoracic spine (HP:0100711)1.86317150
145Visual hallucinations (HP:0002367)1.86159801
146Sparse lateral eyebrow (HP:0005338)1.85580679
147Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84921099
148Reduced subcutaneous adipose tissue (HP:0003758)1.84684899
149Trismus (HP:0000211)1.84428755
150Acute lymphatic leukemia (HP:0006721)1.84192953
151Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83600068
152Abnormality of the gallbladder (HP:0005264)1.82715016
153Easy fatigability (HP:0003388)1.82456239
154Patellar aplasia (HP:0006443)1.81909383
155Febrile seizures (HP:0002373)1.81791619
156Abnormality of the periventricular white matter (HP:0002518)1.81027039
157Insomnia (HP:0100785)1.80596570
158Centrally nucleated skeletal muscle fibers (HP:0003687)1.79751672
159Abnormal respiratory motile cilium morphology (HP:0005938)1.79449527
160Abnormal respiratory epithelium morphology (HP:0012253)1.79449527
161Dysdiadochokinesis (HP:0002075)1.79099711
162Absence seizures (HP:0002121)1.78761213
163Insulin resistance (HP:0000855)1.77427163
164Abnormality of pyrimidine metabolism (HP:0004353)1.76535328
165Germ cell neoplasia (HP:0100728)1.75864531
166Infertility (HP:0000789)1.75704548
167Abnormality of reticulocytes (HP:0004312)1.75431181
168Lymphangioma (HP:0100764)1.75219124
169Mildly elevated creatine phosphokinase (HP:0008180)1.75037403
170Generalized amyotrophy (HP:0003700)1.74691421
171Esophageal varix (HP:0002040)1.74453280
172Axonal loss (HP:0003447)1.72992072
173Multiple lipomas (HP:0001012)1.70130022
174Joint hemorrhage (HP:0005261)1.69677737
175Opisthotonus (HP:0002179)1.68997574
176Abnormality of glycolysis (HP:0004366)1.66646691
177Fasciculations (HP:0002380)1.66133480
178Deformed sella turcica (HP:0002681)1.64329794
179Selective tooth agenesis (HP:0001592)1.63895388
180Elbow flexion contracture (HP:0002987)1.63070055
181Abnormalities of placenta or umbilical cord (HP:0001194)1.62229230
182Increased intramyocellular lipid droplets (HP:0012240)1.61174067
183Truncus arteriosus (HP:0001660)1.60820438
184Flattened epiphyses (HP:0003071)1.60804802
185Hypertensive crisis (HP:0100735)1.60770851
186Xanthomatosis (HP:0000991)1.60630123
187Abnormal trabecular bone morphology (HP:0100671)1.59500511
188Reduced antithrombin III activity (HP:0001976)1.59243241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.93579981
2DDR24.41743467
3EPHA24.34171412
4MAPK154.25364987
5MAP3K63.75383950
6SIK13.57794427
7PINK13.54174865
8SMG13.53827124
9NME23.45412518
10TYRO33.40980240
11MAP3K113.27163249
12IRAK33.11676625
13BMX2.73702526
14FGR2.71962449
15UHMK12.67985261
16SCYL22.67373589
17MATK2.64382384
18ERN12.60299342
19TESK22.51794889
20DAPK12.48331169
21PRKD22.32812106
22VRK22.28706008
23TESK12.23899394
24MST1R2.11059904
25PDGFRA2.02598339
26CSK1.95295877
27MAP3K91.80114177
28MUSK1.73417166
29DYRK1B1.69886693
30PIM21.63779117
31ARAF1.50360333
32YES11.46676561
33TRIB31.44690670
34LATS21.42731951
35BCKDK1.39580013
36PRPF4B1.39387001
37PAK41.38154673
38CDC42BPA1.36256170
39PHKG11.33654782
40PHKG21.33654782
41MAP3K101.22902955
42KDR1.21707315
43TNK21.19724603
44MAP2K21.17637829
45PTK61.11170597
46RPS6KC11.10135017
47RPS6KL11.10135017
48CDK61.09859928
49ILK1.08801183
50CDK71.08379725
51FGFR41.06822392
52PRKD31.04618388
53TRPM71.03609407
54ALK1.01020087
55MAPK110.96941586
56MAP3K30.96868163
57PIM10.96832042
58IRAK20.94206800
59RPS6KA60.92855366
60TBK10.89327755
61CDK80.88988556
62MAP2K30.88300433
63HIPK20.85414532
64GSK3A0.85235600
65STK380.83908513
66PRKCI0.82877605
67PAK60.82767061
68EPHA40.80025295
69KSR20.79312322
70TAOK10.78836319
71PDPK10.77018014
72LRRK20.76942192
73EIF2AK10.76325424
74RAF10.75141376
75AKT30.73657141
76AURKA0.70768798
77SIK30.68785107
78CDK120.66527561
79RPS6KA10.65474660
80LIMK10.64805179
81RPS6KB20.64078141
82MET0.62905792
83SIK20.62418710
84PRKAA10.60931506
85ABL20.60626993
86MAP3K10.60536291
87NTRK30.60098311
88TTN0.59854509
89NEK60.58881528
90MTOR0.58308012
91BUB10.58257009
92BRAF0.55791073
93CHEK20.55284575
94TAOK20.54996170
95NTRK10.54809308
96RPS6KA20.50867421
97AKT20.48436990
98PDGFRB0.48159884
99TAF10.48086844
100MINK10.47228163
101NTRK20.46389577
102MAPK100.44278818
103CDK40.43920068
104EEF2K0.43343644
105CAMK2B0.43321734
106CDK50.42946774
107MAP2K10.42193784
108CDK150.41775412
109PRKG20.41246810
110NEK10.40640597
111EGFR0.40365310
112GRK60.40359958
113RIPK10.39151764
114MAPKAPK20.39106115
115CDK11A0.38766955
116MARK20.38577504
117RPS6KB10.38200809
118CAMK2G0.38021186
119PLK10.37600752
120PRKD10.36676677
121RET0.36526929
122CDK90.36487717
123CDK20.36437316
124CDK180.36205293
125IRAK40.34949779
126EPHB10.34795765
127MAPKAPK30.33539949
128SGK10.32243392
129AURKB0.32179006
130NME10.31798864
131CDK140.31705643
132PDK10.30790235
133CAMK2A0.29848373
134PBK0.29412483
135CAMKK10.29027653
136RPS6KA30.28935892
137MAP3K80.28575280
138MAP3K120.27874361
139PRKCZ0.27404646
140BRSK10.27221613
141MAP4K10.27084894
142MAPK120.26536359
143LMTK20.26132626
144STK110.25512189
145INSR0.24675368
146MAPK10.24269728
147MAPK140.23804232
148CCNB10.22328404
149MAPK30.22113588
150TLK10.22054344
151MAPK40.20489844
152PKN20.19943799
153DAPK30.19807025
154PTK20.19641255
155DAPK20.19477213
156PRKCH0.19307895
157CAMK2D0.17671759
158GSK3B0.16963934
159PAK20.16661357
160PAK10.15631715

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.33325572
2Mismatch repair_Homo sapiens_hsa034303.05450685
3Base excision repair_Homo sapiens_hsa034102.94216263
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.76929464
5Phenylalanine metabolism_Homo sapiens_hsa003602.66860840
6mTOR signaling pathway_Homo sapiens_hsa041502.64627386
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.62916117
8Pentose phosphate pathway_Homo sapiens_hsa000302.46608139
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.42379651
10Dorso-ventral axis formation_Homo sapiens_hsa043202.05945526
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97232346
12Galactose metabolism_Homo sapiens_hsa000521.86349987
13VEGF signaling pathway_Homo sapiens_hsa043701.82738783
14Other glycan degradation_Homo sapiens_hsa005111.79913207
15Carbon metabolism_Homo sapiens_hsa012001.79887592
16Hedgehog signaling pathway_Homo sapiens_hsa043401.79511622
17DNA replication_Homo sapiens_hsa030301.77984314
18Circadian rhythm_Homo sapiens_hsa047101.66987796
19Notch signaling pathway_Homo sapiens_hsa043301.65999712
20Vitamin B6 metabolism_Homo sapiens_hsa007501.60985429
21Longevity regulating pathway - mammal_Homo sapiens_hsa042111.60589915
22Biosynthesis of amino acids_Homo sapiens_hsa012301.58832164
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.58758366
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58644663
25Tyrosine metabolism_Homo sapiens_hsa003501.55445779
26Hippo signaling pathway_Homo sapiens_hsa043901.54873112
27N-Glycan biosynthesis_Homo sapiens_hsa005101.51592718
28mRNA surveillance pathway_Homo sapiens_hsa030151.50371607
29Bladder cancer_Homo sapiens_hsa052191.48682892
30Olfactory transduction_Homo sapiens_hsa047401.46878362
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44812197
32Gap junction_Homo sapiens_hsa045401.43951735
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39401191
34Oocyte meiosis_Homo sapiens_hsa041141.39247448
35ErbB signaling pathway_Homo sapiens_hsa040121.37992989
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34834795
37Folate biosynthesis_Homo sapiens_hsa007901.32540617
38Fatty acid elongation_Homo sapiens_hsa000621.32172534
39Arginine and proline metabolism_Homo sapiens_hsa003301.29653293
40Adherens junction_Homo sapiens_hsa045201.27333143
41Pyrimidine metabolism_Homo sapiens_hsa002401.23335981
42Choline metabolism in cancer_Homo sapiens_hsa052311.19408426
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19400846
44Vibrio cholerae infection_Homo sapiens_hsa051101.16972747
45Pyruvate metabolism_Homo sapiens_hsa006201.16195585
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15750486
47Wnt signaling pathway_Homo sapiens_hsa043101.15092976
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14292103
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.13262577
50Long-term potentiation_Homo sapiens_hsa047201.12130774
51Chronic myeloid leukemia_Homo sapiens_hsa052201.11883285
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07538157
53Sulfur relay system_Homo sapiens_hsa041221.07128231
54Glioma_Homo sapiens_hsa052141.06600669
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06565189
56Colorectal cancer_Homo sapiens_hsa052101.04365341
57Insulin signaling pathway_Homo sapiens_hsa049101.04204815
58Acute myeloid leukemia_Homo sapiens_hsa052211.03991891
59Endometrial cancer_Homo sapiens_hsa052131.03227348
60Estrogen signaling pathway_Homo sapiens_hsa049151.03211003
61GnRH signaling pathway_Homo sapiens_hsa049121.03182337
62Synaptic vesicle cycle_Homo sapiens_hsa047211.02480663
63Shigellosis_Homo sapiens_hsa051311.01757586
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.01666749
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.98961991
66Ribosome_Homo sapiens_hsa030100.97562219
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96978300
68One carbon pool by folate_Homo sapiens_hsa006700.95421325
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95371486
70Fructose and mannose metabolism_Homo sapiens_hsa000510.94160829
71Thyroid cancer_Homo sapiens_hsa052160.93586590
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92347784
73Fatty acid metabolism_Homo sapiens_hsa012120.90535318
74Primary immunodeficiency_Homo sapiens_hsa053400.89631912
75Arginine biosynthesis_Homo sapiens_hsa002200.89606599
76Amphetamine addiction_Homo sapiens_hsa050310.89102330
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87953826
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87033308
79Lysine degradation_Homo sapiens_hsa003100.86767316
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85320209
81Non-small cell lung cancer_Homo sapiens_hsa052230.84618139
82MAPK signaling pathway_Homo sapiens_hsa040100.84613349
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83547666
84Insulin resistance_Homo sapiens_hsa049310.83136497
85Glutathione metabolism_Homo sapiens_hsa004800.83133189
86GABAergic synapse_Homo sapiens_hsa047270.82940640
87Sulfur metabolism_Homo sapiens_hsa009200.82899478
88RNA transport_Homo sapiens_hsa030130.81963750
89Nucleotide excision repair_Homo sapiens_hsa034200.79894435
90Endocytosis_Homo sapiens_hsa041440.76285402
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76035320
92B cell receptor signaling pathway_Homo sapiens_hsa046620.75637592
93TGF-beta signaling pathway_Homo sapiens_hsa043500.75049884
94Dopaminergic synapse_Homo sapiens_hsa047280.74072233
95Pancreatic cancer_Homo sapiens_hsa052120.73856766
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73817420
97Long-term depression_Homo sapiens_hsa047300.73053484
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72903936
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72829775
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72361512
101Basal cell carcinoma_Homo sapiens_hsa052170.70421485
102Tight junction_Homo sapiens_hsa045300.69819090
103Spliceosome_Homo sapiens_hsa030400.69545738
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68767651
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67820472
106Oxytocin signaling pathway_Homo sapiens_hsa049210.66687287
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66159798
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66013376
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.65227985
110PPAR signaling pathway_Homo sapiens_hsa033200.64864852
111Nicotine addiction_Homo sapiens_hsa050330.64829190
112Hepatitis C_Homo sapiens_hsa051600.63234592
113AMPK signaling pathway_Homo sapiens_hsa041520.63172413
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62662325
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62214144
116Prion diseases_Homo sapiens_hsa050200.62051282
117Histidine metabolism_Homo sapiens_hsa003400.61546213
118Morphine addiction_Homo sapiens_hsa050320.60952901
119p53 signaling pathway_Homo sapiens_hsa041150.60856594
120Bile secretion_Homo sapiens_hsa049760.60574552
121Gastric acid secretion_Homo sapiens_hsa049710.60392738
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59442704
123Glucagon signaling pathway_Homo sapiens_hsa049220.59242697
124MicroRNAs in cancer_Homo sapiens_hsa052060.58901679
125Salivary secretion_Homo sapiens_hsa049700.58168256
126Glutamatergic synapse_Homo sapiens_hsa047240.56962491
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56567454
128Lysosome_Homo sapiens_hsa041420.55569639
129Proteoglycans in cancer_Homo sapiens_hsa052050.54298064
130Fatty acid degradation_Homo sapiens_hsa000710.54009580
131Starch and sucrose metabolism_Homo sapiens_hsa005000.53752271
132Metabolic pathways_Homo sapiens_hsa011000.52499402
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52125629
134Rap1 signaling pathway_Homo sapiens_hsa040150.50946031
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50703185
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50068774
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49132552
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48688367
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48321885
140Sphingolipid metabolism_Homo sapiens_hsa006000.47609156
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.46083025
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45745341
143Melanogenesis_Homo sapiens_hsa049160.45191243
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44991748
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.44499147
146Fanconi anemia pathway_Homo sapiens_hsa034600.42708652
147Small cell lung cancer_Homo sapiens_hsa052220.42659680
148Fat digestion and absorption_Homo sapiens_hsa049750.41642500
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.40962521
150Nitrogen metabolism_Homo sapiens_hsa009100.40647964
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40328815
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.39812370
153Circadian entrainment_Homo sapiens_hsa047130.39676014
154Vitamin digestion and absorption_Homo sapiens_hsa049770.39372799
155Proteasome_Homo sapiens_hsa030500.39091429
156Peroxisome_Homo sapiens_hsa041460.38267616
157Inositol phosphate metabolism_Homo sapiens_hsa005620.34388194
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.30837439
159Complement and coagulation cascades_Homo sapiens_hsa046100.30201819

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