THEMIS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact6.00419418
2modulation by symbiont of host immune response (GO:0052553)6.00419418
3positive regulation by symbiont of host defense response (GO:0052509)6.00419418
4modulation by symbiont of host defense response (GO:0052031)6.00419418
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.00419418
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.00419418
7regulation of interferon-beta biosynthetic process (GO:0045357)5.68027398
8neutrophil activation involved in immune response (GO:0002283)5.41458718
9positive regulation of interferon-alpha production (GO:0032727)5.38570185
10regulation of interferon-alpha production (GO:0032647)5.11336339
11antigen processing and presentation of endogenous antigen (GO:0019883)5.05948246
12immunoglobulin mediated immune response (GO:0016064)5.05816337
13detection of other organism (GO:0098543)5.01715725
14macrophage activation involved in immune response (GO:0002281)4.81472861
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80151379
16detection of bacterium (GO:0016045)4.78477281
17response to peptidoglycan (GO:0032494)4.76085623
18regulation of B cell receptor signaling pathway (GO:0050855)4.75380749
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.52730278
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.52730278
21respiratory burst (GO:0045730)4.52227133
22regulation of gamma-delta T cell activation (GO:0046643)4.29171375
23detection of external biotic stimulus (GO:0098581)4.29083436
24detection of molecule of bacterial origin (GO:0032490)4.24112160
25type I interferon signaling pathway (GO:0060337)4.21186608
26cellular response to type I interferon (GO:0071357)4.21186608
27response to type I interferon (GO:0034340)4.17368245
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.16830952
29response to host immune response (GO:0052572)4.16830952
30granulocyte activation (GO:0036230)4.12719573
31neutrophil activation (GO:0042119)4.12032585
32positive regulation of interferon-beta production (GO:0032728)4.11510443
33interferon-gamma-mediated signaling pathway (GO:0060333)4.07737484
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.98673923
35cellular response to exogenous dsRNA (GO:0071360)3.97836156
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.93030474
37positive regulation of antigen processing and presentation (GO:0002579)3.89606848
38positive regulation of gamma-delta T cell activation (GO:0046645)3.88345858
39cellular response to zinc ion (GO:0071294)3.87578666
40detection of biotic stimulus (GO:0009595)3.82927411
41positive regulation of mast cell activation (GO:0033005)3.82556523
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.76698485
43response to host (GO:0075136)3.76698485
44response to host defenses (GO:0052200)3.76698485
45microglial cell activation (GO:0001774)3.74202577
46lipopolysaccharide-mediated signaling pathway (GO:0031663)3.74090257
47production of molecular mediator involved in inflammatory response (GO:0002532)3.73541059
48myeloid cell activation involved in immune response (GO:0002275)3.72233697
49B cell mediated immunity (GO:0019724)3.70974615
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.69555326
51positive regulation of mast cell degranulation (GO:0043306)3.67816016
52positive regulation of mast cell activation involved in immune response (GO:0033008)3.67816016
53negative regulation of T cell mediated immunity (GO:0002710)3.62943614
54B cell receptor signaling pathway (GO:0050853)3.62126628
55T cell migration (GO:0072678)3.60659472
56cellular extravasation (GO:0045123)3.60616415
57response to muramyl dipeptide (GO:0032495)3.60430169
58defense response to protozoan (GO:0042832)3.60036442
59positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.59492428
60regulation of gamma-delta T cell differentiation (GO:0045586)3.58122313
61negative regulation of leukocyte mediated immunity (GO:0002704)3.55473936
62positive regulation of B cell differentiation (GO:0045579)3.52725460
63regulation of B cell differentiation (GO:0045577)3.51714675
64regulation of mast cell degranulation (GO:0043304)3.49042460
65natural killer cell mediated immunity (GO:0002228)3.47675238
66natural killer cell mediated cytotoxicity (GO:0042267)3.47675238
67macrophage activation (GO:0042116)3.40603599
68leukocyte mediated cytotoxicity (GO:0001909)3.38901591
69negative regulation of erythrocyte differentiation (GO:0045647)3.34606031
70myeloid dendritic cell differentiation (GO:0043011)3.34167259
71leukocyte migration involved in inflammatory response (GO:0002523)3.33924299
72neutrophil mediated immunity (GO:0002446)3.33783466
73response to interleukin-15 (GO:0070672)3.30541900
74positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.30078171
75positive regulation of toll-like receptor signaling pathway (GO:0034123)3.30034970
76regulation of T cell tolerance induction (GO:0002664)3.28749442
77cellular response to interferon-beta (GO:0035458)3.28412541
78regulation of mast cell activation (GO:0033003)3.28324271
79regulation of antigen processing and presentation (GO:0002577)3.28090683
80leukocyte aggregation (GO:0070486)3.26413519
81regulation of interleukin-12 biosynthetic process (GO:0045075)3.25167189
82myeloid dendritic cell activation (GO:0001773)3.25026168
83regulation of tolerance induction (GO:0002643)3.24434774
84antigen processing and presentation via MHC class Ib (GO:0002475)3.23502198
85positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22862830
86regulation of mast cell activation involved in immune response (GO:0033006)3.22816821
87T-helper 1 type immune response (GO:0042088)3.22048684
88Arp2/3 complex-mediated actin nucleation (GO:0034314)3.18692315
89response to interferon-alpha (GO:0035455)3.17396432
90response to protozoan (GO:0001562)3.14554677
91positive regulation of interleukin-12 production (GO:0032735)3.14161845
92positive thymic T cell selection (GO:0045059)3.13446294
93regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.12110359
94negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10966662
95cellular response to interferon-gamma (GO:0071346)3.10351659
96regulation of interferon-beta production (GO:0032648)3.09282036
97negative thymic T cell selection (GO:0045060)3.07100138
98positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05038366
99myeloid leukocyte activation (GO:0002274)3.03570577
100negative regulation of interleukin-12 production (GO:0032695)3.01657262
101leukocyte degranulation (GO:0043299)3.01347549
102regulation of interleukin-8 biosynthetic process (GO:0045414)3.01267429
103positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.00938026
104I-kappaB phosphorylation (GO:0007252)3.00052318
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99773564
106positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99760432
107regulation of T-helper 2 cell differentiation (GO:0045628)2.99324125
108regulation of T-helper 1 cell differentiation (GO:0045625)2.99050889
109cellular response to interleukin-15 (GO:0071350)2.98709759
110regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98646192
111negative T cell selection (GO:0043383)2.96745558
112negative regulation of viral genome replication (GO:0045071)2.96215406
113negative regulation of cell killing (GO:0031342)2.96190915
114negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96190915
115positive regulation of cellular amide metabolic process (GO:0034250)2.96145726
116negative regulation of cytokine production involved in immune response (GO:0002719)2.96012932
117myeloid leukocyte mediated immunity (GO:0002444)2.95194528
118regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95162149
119regulation of alpha-beta T cell proliferation (GO:0046640)2.94503437
120pinocytosis (GO:0006907)2.94362142
121negative regulation of innate immune response (GO:0045824)2.92751231
122response to interferon-beta (GO:0035456)2.91565098
123lymphocyte chemotaxis (GO:0048247)2.91446269
124positive regulation of chemokine biosynthetic process (GO:0045080)2.91403292
125positive regulation of type 2 immune response (GO:0002830)2.90750967
126regulation of leukocyte degranulation (GO:0043300)2.89300834
127positive regulation of leukocyte degranulation (GO:0043302)2.88245631
128germinal center formation (GO:0002467)2.88144906
129regulation of interleukin-12 production (GO:0032655)2.86963425
130lymphocyte mediated immunity (GO:0002449)2.85744244
131regulation of mononuclear cell migration (GO:0071675)2.85054522
132NIK/NF-kappaB signaling (GO:0038061)2.83863264
133regulation of T cell mediated cytotoxicity (GO:0001914)2.83518780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.19125610
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.82175161
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.58110564
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.57780089
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.51211913
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.00027170
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.88613424
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.83575705
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.52332976
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50132023
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.29264538
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16396801
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.02174663
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.97532231
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.62750635
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62003716
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.61765431
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.59277102
19SPI1_23547873_ChIP-Seq_NB4_Human2.39923184
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38492219
21VDR_21846776_ChIP-Seq_THP-1_Human2.36045651
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.35806101
23VDR_24763502_ChIP-Seq_THP-1_Human2.09886003
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07864059
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04721126
26MAF_26560356_Chip-Seq_TH1_Human2.02745791
27MYB_26560356_Chip-Seq_TH2_Human2.01630466
28SCL_19346495_ChIP-Seq_HPC-7_Human1.92568759
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.91076015
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90850660
31SPI1_23127762_ChIP-Seq_K562_Human1.89236604
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85215321
33RUNX_20019798_ChIP-Seq_JUKART_Human1.82592467
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79558561
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.78872003
36PU_27001747_Chip-Seq_BMDM_Mouse1.78489767
37MYC_22102868_ChIP-Seq_BL_Human1.77860002
38MYB_26560356_Chip-Seq_TH1_Human1.76945799
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73231622
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69987174
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67403103
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65597170
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.60294188
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58601316
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57507072
46UTX_26944678_Chip-Seq_JUKART_Human1.49297368
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47624901
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47552046
49GATA1_22025678_ChIP-Seq_K562_Human1.45162274
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45027687
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42847582
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40112966
53TCF7_22412390_ChIP-Seq_EML_Mouse1.39787088
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38359692
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35320466
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33289022
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32796452
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29713031
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27125736
60GATA3_27048872_Chip-Seq_THYMUS_Human1.24769962
61E2F7_22180533_ChIP-Seq_HELA_Human1.24625582
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23650599
63GATA3_26560356_Chip-Seq_TH2_Human1.21173862
64VDR_24787735_ChIP-Seq_THP-1_Human1.19862756
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19455309
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16190112
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14902734
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14557641
69MAF_26560356_Chip-Seq_TH2_Human1.13846461
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12292531
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12137507
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11382261
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10289060
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09604304
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.09134836
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09098213
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.07549773
78KDM2B_26808549_Chip-Seq_DND41_Human1.07034127
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05322832
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05297886
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.02337744
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96255340
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95908367
84ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94975762
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94282369
86RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87893325
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87761496
88SPI1_20517297_ChIP-Seq_HL60_Human0.87191117
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.85699171
90LXR_22292898_ChIP-Seq_THP-1_Human0.84859063
91EGR1_19032775_ChIP-ChIP_M12_Human0.82906083
92TFEB_21752829_ChIP-Seq_HELA_Human0.80767126
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80108940
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80055452
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79966605
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75375671
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.71121949
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.70374790
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69747710
100GATA2_19941826_ChIP-Seq_K562_Human0.69288499
101GATA1_19941826_ChIP-Seq_K562_Human0.68191022
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.68007721
103BCL6_27268052_Chip-Seq_Bcells_Human0.67013669
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.65282244
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.64806354
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64343012
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64279278
108HOXB4_20404135_ChIP-ChIP_EML_Mouse0.64031241
109NCOR1_26117541_ChIP-Seq_K562_Human0.62530545
110STAT1_20625510_ChIP-Seq_HELA_Human0.61900688
111BCOR_27268052_Chip-Seq_Bcells_Human0.61834964
112P300_27268052_Chip-Seq_Bcells_Human0.61754814
113SMRT_27268052_Chip-Seq_Bcells_Human0.60097345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.14927918
2MP0003436_decreased_susceptibility_to3.58329390
3MP0003303_peritoneal_inflammation3.56475669
4MP0001790_abnormal_immune_system3.49470813
5MP0005387_immune_system_phenotype3.49470813
6MP0009785_altered_susceptibility_to3.37114548
7MP0000685_abnormal_immune_system3.23379330
8MP0002148_abnormal_hypersensitivity_rea3.19069021
9MP0005000_abnormal_immune_tolerance3.13194415
10MP0002419_abnormal_innate_immunity3.11538320
11MP0001800_abnormal_humoral_immune3.09831892
12MP0005025_abnormal_response_to2.99620431
13MP0006082_CNS_inflammation2.98929638
14MP0002452_abnormal_antigen_presenting2.91246137
15MP0005058_abnormal_lysosome_morphology2.81975339
16MP0005671_abnormal_response_to2.81719448
17MP0004510_myositis2.68398460
18MP0002723_abnormal_immune_serum2.67627558
19MP0003724_increased_susceptibility_to2.47944556
20MP0001819_abnormal_immune_cell2.47133826
21MP0002420_abnormal_adaptive_immunity2.44850176
22MP0009278_abnormal_bone_marrow2.22079999
23MP0001853_heart_inflammation2.06602850
24MP0003172_abnormal_lysosome_physiology2.05606948
25MP0005464_abnormal_platelet_physiology2.03169223
26MP0002405_respiratory_system_inflammati2.02465532
27MP0001533_abnormal_skeleton_physiology1.92123234
28MP0000716_abnormal_immune_system1.91339918
29MP0001845_abnormal_inflammatory_respons1.89277021
30MP0002398_abnormal_bone_marrow1.87834499
31MP0002166_altered_tumor_susceptibility1.78156184
32MP0009840_abnormal_foam_cell1.76147570
33MP0004947_skin_inflammation1.70162624
34MP0000689_abnormal_spleen_morphology1.69436492
35MP0010155_abnormal_intestine_physiology1.68283317
36MP0003191_abnormal_cellular_cholesterol1.64505052
37MP0002132_abnormal_respiratory_system1.62811957
38MP0008469_abnormal_protein_level1.62448442
39MP0005451_abnormal_body_composition1.62077489
40MP0001545_abnormal_hematopoietic_system1.61655595
41MP0005397_hematopoietic_system_phenotyp1.61655595
42MP0005310_abnormal_salivary_gland1.60316250
43MP0009333_abnormal_splenocyte_physiolog1.59828791
44MP0003075_altered_response_to1.58044721
45MP0002429_abnormal_blood_cell1.53917923
46MP0003448_altered_tumor_morphology1.53134866
47MP0009764_decreased_sensitivity_to1.52828465
48MP0002006_tumorigenesis1.52041389
49MP0000343_altered_response_to1.49679196
50MP0002722_abnormal_immune_system1.47054498
51MP0003300_gastrointestinal_ulcer1.42171289
52MP0003183_abnormal_peptide_metabolism1.37239930
53MP0005174_abnormal_tail_pigmentation1.34876923
54MP0000604_amyloidosis1.22031855
55MP0000569_abnormal_digit_pigmentation1.21411275
56MP0002138_abnormal_hepatobiliary_system1.21074833
57MP0010307_abnormal_tumor_latency1.15529603
58MP0000858_altered_metastatic_potential1.15135415
59MP0001873_stomach_inflammation1.10307452
60MP0002998_abnormal_bone_remodeling1.09955937
61MP0003763_abnormal_thymus_physiology1.09734058
62MP0004381_abnormal_hair_follicle1.05922721
63MP0003690_abnormal_glial_cell1.05626463
64MP0005166_decreased_susceptibility_to1.05539922
65MP0002933_joint_inflammation1.04847618
66MP0002396_abnormal_hematopoietic_system1.03904418
67MP0005076_abnormal_cell_differentiation1.03546300
68MP0008004_abnormal_stomach_pH1.01504899
69MP0000465_gastrointestinal_hemorrhage1.00088566
70MP0003806_abnormal_nucleotide_metabolis0.95446310
71MP0002277_abnormal_respiratory_mucosa0.95437935
72MP0004808_abnormal_hematopoietic_stem0.93647881
73MP0003828_pulmonary_edema0.91335104
74MP0000015_abnormal_ear_pigmentation0.89052557
75MP0005164_abnormal_response_to0.87915901
76MP0001851_eye_inflammation0.87637994
77MP0005390_skeleton_phenotype0.86900149
78MP0004782_abnormal_surfactant_physiolog0.84581276
79MP0009763_increased_sensitivity_to0.84328756
80MP0003045_fibrosis0.82831343
81MP0000703_abnormal_thymus_morphology0.81315785
82MP0003453_abnormal_keratinocyte_physiol0.80045769
83MP0008057_abnormal_DNA_replication0.76744626
84MP0000371_diluted_coat_color0.75116121
85MP0003566_abnormal_cell_adhesion0.74854614
86MP0000490_abnormal_crypts_of0.74046305
87MP0000249_abnormal_blood_vessel0.72393432
88MP0009765_abnormal_xenobiotic_induced0.71625253
89MP0003866_abnormal_defecation0.71177141
90MP0005075_abnormal_melanosome_morpholog0.69522932
91MP0002332_abnormal_exercise_endurance0.67241886
92MP0008874_decreased_physiological_sensi0.64785770
93MP0003656_abnormal_erythrocyte_physiolo0.64508373
94MP0003091_abnormal_cell_migration0.63995665
95MP0005167_abnormal_blood-brain_barrier0.63792507
96MP0002019_abnormal_tumor_incidence0.62893089
97MP0004883_abnormal_blood_vessel0.62016531
98MP0001986_abnormal_taste_sensitivity0.59033840
99MP0002136_abnormal_kidney_physiology0.57680327
100MP0000920_abnormal_myelination0.57108242
101MP0001663_abnormal_digestive_system0.55595626
102MP0003221_abnormal_cardiomyocyte_apopto0.55014548
103MP0005319_abnormal_enzyme/_coenzyme0.52053195
104MP0003795_abnormal_bone_structure0.51416826
105MP0000767_abnormal_smooth_muscle0.50839445
106MP0010352_gastrointestinal_tract_polyps0.49854000
107MP0000609_abnormal_liver_physiology0.49306826
108MP0005023_abnormal_wound_healing0.48346934
109MP0003329_amyloid_beta_deposits0.47849565
110MP0002009_preneoplasia0.47566138
111MP0001958_emphysema0.45367745
112MP0008260_abnormal_autophagy0.44209238
113MP0008873_increased_physiological_sensi0.43156299
114MP0009115_abnormal_fat_cell0.42854791
115MP0002928_abnormal_bile_duct0.42311518

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.21761478
2Recurrent bacterial skin infections (HP:0005406)6.74862948
3Eczematoid dermatitis (HP:0000976)6.16941691
4Recurrent gram-negative bacterial infections (HP:0005420)5.18832452
5Systemic lupus erythematosus (HP:0002725)4.63322604
6Recurrent skin infections (HP:0001581)4.47670581
7Abnormality of macrophages (HP:0004311)4.40290533
8Recurrent viral infections (HP:0004429)4.34278398
9Recurrent fungal infections (HP:0002841)4.30809122
10Colitis (HP:0002583)4.29408251
11Mediastinal lymphadenopathy (HP:0100721)4.28494858
12Vacuolated lymphocytes (HP:0001922)4.09195692
13Elevated erythrocyte sedimentation rate (HP:0003565)4.01022911
14Gastrointestinal infarctions (HP:0005244)3.99353623
15Myositis (HP:0100614)3.96397247
16Obstructive lung disease (HP:0006536)3.79624971
17Chronic obstructive pulmonary disease (HP:0006510)3.79624971
18Increased cerebral lipofuscin (HP:0011813)3.77699925
19Agammaglobulinemia (HP:0004432)3.75882522
20Cellulitis (HP:0100658)3.74994760
21Chronic otitis media (HP:0000389)3.74035957
22Autoimmune thrombocytopenia (HP:0001973)3.71880981
23Recurrent cutaneous fungal infections (HP:0011370)3.66085519
24Chronic mucocutaneous candidiasis (HP:0002728)3.66085519
25Inflammation of the large intestine (HP:0002037)3.63108487
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.56650594
27Pustule (HP:0200039)3.56520206
28Gingivitis (HP:0000230)3.55094995
29Meningitis (HP:0001287)3.50030833
30Vasculitis (HP:0002633)3.47784548
31Gastrointestinal inflammation (HP:0004386)3.45789385
32Increased neuronal autofluorescent lipopigment (HP:0002074)3.44334285
33Orchitis (HP:0100796)3.39862890
34Keratoconjunctivitis (HP:0001096)3.30417097
35Increased IgM level (HP:0003496)3.23694403
36Dysostosis multiplex (HP:0000943)3.23030049
37Panhypogammaglobulinemia (HP:0003139)3.20117762
38Glomerulonephritis (HP:0000099)3.18485350
39T lymphocytopenia (HP:0005403)3.12196431
40Periodontitis (HP:0000704)3.11448238
41Optic neuritis (HP:0100653)3.05517502
42Retrobulbar optic neuritis (HP:0100654)3.05517502
43Prolonged bleeding time (HP:0003010)3.04497103
44Spontaneous hematomas (HP:0007420)3.03450426
45Abnormality of T cell number (HP:0011839)3.00609180
46Hematochezia (HP:0002573)2.98680104
47Abnormality of glycolipid metabolism (HP:0010969)2.95957440
48Abnormality of liposaccharide metabolism (HP:0010968)2.95957440
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.95957440
50Amyloidosis (HP:0011034)2.94530754
51Recurrent lower respiratory tract infections (HP:0002783)2.92713292
52Interstitial pulmonary disease (HP:0006530)2.90051092
53Episodic fever (HP:0001954)2.80105358
54Recurrent pneumonia (HP:0006532)2.78730097
55Osteomyelitis (HP:0002754)2.78483946
56Stomatitis (HP:0010280)2.76337413
57Urinary glycosaminoglycan excretion (HP:0003541)2.73609221
58Mucopolysacchariduria (HP:0008155)2.73609221
59Hypochromic microcytic anemia (HP:0004840)2.70323860
60Basal ganglia calcification (HP:0002135)2.65372524
61Recurrent bronchitis (HP:0002837)2.64790612
62Pulmonary infiltrates (HP:0002113)2.62220726
63Hypergammaglobulinemia (HP:0010702)2.62132200
64Urticaria (HP:0001025)2.61892292
65Hypochromic anemia (HP:0001931)2.60594131
66IgM deficiency (HP:0002850)2.59701560
67Pulmonary embolism (HP:0002204)2.59037773
68Anorexia (HP:0002039)2.58367139
69Abnormality of polysaccharide metabolism (HP:0011012)2.57744699
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57744699
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57744699
72Myocardial infarction (HP:0001658)2.56394148
73Abnormality of T cell physiology (HP:0011840)2.56045121
74Nasal polyposis (HP:0100582)2.56028740
75Disinhibition (HP:0000734)2.47219238
76Abnormality of the nasal mucosa (HP:0000433)2.46154786
77Loss of speech (HP:0002371)2.45432064
78Peritonitis (HP:0002586)2.41629284
79Gangrene (HP:0100758)2.38679534
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38623914
81Granulocytopenia (HP:0001913)2.38278739
82Gastrointestinal stroma tumor (HP:0100723)2.38022659
83Encephalitis (HP:0002383)2.37404764
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.36123995
85Arterial thrombosis (HP:0004420)2.35578000
86Abnormality of the pleura (HP:0002103)2.33810907
87Axonal loss (HP:0003447)2.33223381
88Petechiae (HP:0000967)2.32827823
89Purpura (HP:0000979)2.32824737
90Leukocytosis (HP:0001974)2.32547993
91Nephritis (HP:0000123)2.32501447
92Increased serum ferritin (HP:0003281)2.32304126
93Gingival bleeding (HP:0000225)2.28124764
94Thrombocytosis (HP:0001894)2.23305446
95Eosinophilia (HP:0001880)2.21178105
96Abnormality of T cells (HP:0002843)2.20566406
97Abnormality of complement system (HP:0005339)2.19685093
98Prostate neoplasm (HP:0100787)2.18038917
99IgA deficiency (HP:0002720)2.15087112
100Hemoptysis (HP:0002105)2.14603323
101Skin ulcer (HP:0200042)2.11721757
102Agnosia (HP:0010524)2.11337532
103Glomerulopathy (HP:0100820)2.11032861
104Sepsis (HP:0100806)2.10810921
105Abnormality of iron homeostasis (HP:0011031)2.10664720
106Thick nail (HP:0001805)2.10550563
107Emphysema (HP:0002097)2.10362120
108Abnormality of the peritoneum (HP:0002585)2.10007916
109Microcytic anemia (HP:0001935)2.09451525
110Hepatosplenomegaly (HP:0001433)2.08157154
111Increased IgE level (HP:0003212)2.06645825
112Vertigo (HP:0002321)2.06319834
113Abnormality of cells of the lymphoid lineage (HP:0012140)2.06010617
114Viral hepatitis (HP:0006562)2.05613876
115Recurrent sinusitis (HP:0011108)2.05231669
116Chronic sinusitis (HP:0011109)2.04873375
117Polyneuropathy (HP:0001271)2.04634366
118Lymphopenia (HP:0001888)2.04595844
119Keratoconjunctivitis sicca (HP:0001097)2.01118686
120Abnormality of the endocardium (HP:0004306)2.00514274
121Premature loss of primary teeth (HP:0006323)2.00285682
122Abnormality of the prostate (HP:0008775)1.99543966
123Chest pain (HP:0100749)1.99233611
124Slow saccadic eye movements (HP:0000514)1.98887836
125Restrictive lung disease (HP:0002091)1.97406184
126Epistaxis (HP:0000421)1.97008695
127Osteolytic defects of the hand bones (HP:0009699)1.96470484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.10773663
2MAP4K13.80229629
3TYK23.71141520
4MAP3K143.53569979
5IRAK43.43782526
6RIPK43.37350878
7TBK13.02145175
8ERN12.78190446
9PRPF4B2.66098674
10CSK2.42768685
11KIT2.40028609
12IRAK32.39350564
13IKBKE2.25618090
14TAOK32.20507941
15JAK12.14578192
16IKBKB2.12220325
17JAK32.04302229
18TNK21.97718655
19CSF1R1.88302010
20FGR1.85532952
21MAP3K31.78992426
22BTK1.78788995
23ZAP701.73480276
24SYK1.72312906
25MATK1.71777299
26MAP3K131.68296942
27STK101.63388462
28TAOK11.62494785
29HCK1.50395332
30TGFBR21.48529657
31EPHB11.46141394
32TEC1.42313366
33PIM21.38816941
34LYN1.37038982
35FES1.29849242
36NEK91.25871190
37MAP3K11.23722087
38PIM11.20509862
39SIK21.20000663
40CHUK1.18888809
41TXK1.15482766
42LCK1.15196252
43MAP3K101.11187254
44CLK11.09793581
45GRK61.05674976
46MAP2K31.01850335
47JAK21.01402713
48KSR21.01377659
49YES10.97642539
50RPS6KA40.97593467
51ITK0.93831636
52BMX0.90964585
53MARK20.90522830
54FGFR40.90428842
55CDK120.86528228
56MARK30.83466550
57PBK0.83154923
58MAP3K110.80849978
59BMPR20.80745586
60FGFR30.78079113
61STK40.77922418
62TRPM70.74366025
63MAP3K60.72861047
64PRKD20.72357739
65CDK190.72254856
66MAPK70.71478368
67LRRK20.71010504
68TESK20.69116079
69ABL10.66061449
70RPS6KA60.65847156
71PIK3CG0.65280650
72MAPK120.64803458
73MAP3K50.60644496
74CDK60.60634914
75EGFR0.60439347
76MAP3K70.57687995
77RPS6KL10.57098611
78RPS6KC10.57098611
79PRKCD0.56524968
80MAPK110.55259020
81SMG10.55150792
82MAPK150.55036331
83PTK2B0.55020250
84GRK70.53290690
85MAPKAPK20.51755066
86PRKCQ0.49018818
87SIK30.48247478
88ABL20.47831995
89SGK30.47754206
90MAP3K20.47187773
91CDK90.46551276
92CAMK1D0.46535672
93STK110.44687540
94DYRK1B0.44017108
95EPHA30.43922613
96MAPK40.43620984
97CDC42BPA0.43426878
98PDK10.40284408
99IRAK10.39876548
100CAMKK20.38712938
101FLT30.38189596
102TAOK20.36546664
103NLK0.34773412
104CAMKK10.33753252
105NME20.33379717
106MAP3K80.32828232
107PDPK10.31729107
108EIF2AK20.31599833
109RAF10.31326453
110FYN0.31112515
111SIK10.30871627
112MOS0.30714230
113MAP2K60.30638160
114CDK40.30547884
115DAPK20.30374159
116MAP2K40.30367488
117RET0.30238932
118SGK20.30046889
119PTK60.29960407
120HIPK20.29817704
121RIPK10.29630684
122TRIB30.29616774
123TTN0.27922910
124ICK0.26372277
125ERBB30.24586618
126MAPK30.24326173
127MST40.24141884
128RPS6KA10.24061768
129INSR0.23638714
130PAK40.22803909
131IRAK20.21100756

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.46235408
2Leishmaniasis_Homo sapiens_hsa051403.39633465
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.82073370
4B cell receptor signaling pathway_Homo sapiens_hsa046622.63372282
5Osteoclast differentiation_Homo sapiens_hsa043802.62503247
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.58502209
7Primary immunodeficiency_Homo sapiens_hsa053402.45724887
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.39180803
9Pertussis_Homo sapiens_hsa051332.27899886
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26283611
11Tuberculosis_Homo sapiens_hsa051522.22139556
12Measles_Homo sapiens_hsa051622.21350787
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.16980572
14Antigen processing and presentation_Homo sapiens_hsa046122.08175182
15Allograft rejection_Homo sapiens_hsa053302.00838246
16Graft-versus-host disease_Homo sapiens_hsa053321.98859904
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.98507993
18Influenza A_Homo sapiens_hsa051641.98339281
19Lysosome_Homo sapiens_hsa041421.97530602
20Legionellosis_Homo sapiens_hsa051341.95977258
21Malaria_Homo sapiens_hsa051441.95232598
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91381156
23Other glycan degradation_Homo sapiens_hsa005111.89957527
24Herpes simplex infection_Homo sapiens_hsa051681.82150297
25Toxoplasmosis_Homo sapiens_hsa051451.79500080
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74993201
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72599715
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63550009
29TNF signaling pathway_Homo sapiens_hsa046681.60351644
30Chemokine signaling pathway_Homo sapiens_hsa040621.58939728
31Shigellosis_Homo sapiens_hsa051311.57280605
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56390493
33Asthma_Homo sapiens_hsa053101.55508462
34Hematopoietic cell lineage_Homo sapiens_hsa046401.47070974
35Salmonella infection_Homo sapiens_hsa051321.44633581
36Rheumatoid arthritis_Homo sapiens_hsa053231.42404448
37Apoptosis_Homo sapiens_hsa042101.39493977
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35814164
39Phagosome_Homo sapiens_hsa041451.35015489
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.34148293
41Viral myocarditis_Homo sapiens_hsa054161.31998247
42African trypanosomiasis_Homo sapiens_hsa051431.25955945
43Hepatitis B_Homo sapiens_hsa051611.25307204
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14630460
45Hepatitis C_Homo sapiens_hsa051601.09945837
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.05314218
47Acute myeloid leukemia_Homo sapiens_hsa052210.95700784
48T cell receptor signaling pathway_Homo sapiens_hsa046600.94071262
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90497213
50Autoimmune thyroid disease_Homo sapiens_hsa053200.88904524
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86237968
52Epstein-Barr virus infection_Homo sapiens_hsa051690.83593962
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82960024
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82483734
55Chronic myeloid leukemia_Homo sapiens_hsa052200.82228470
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80753339
57Pancreatic cancer_Homo sapiens_hsa052120.79871507
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79628691
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78823219
60Complement and coagulation cascades_Homo sapiens_hsa046100.76594650
61Type I diabetes mellitus_Homo sapiens_hsa049400.75093266
62Platelet activation_Homo sapiens_hsa046110.74177130
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72130278
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69789107
65Renal cell carcinoma_Homo sapiens_hsa052110.68834936
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.68617222
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63293425
68Notch signaling pathway_Homo sapiens_hsa043300.62981083
69Base excision repair_Homo sapiens_hsa034100.61422437
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58720337
71Prolactin signaling pathway_Homo sapiens_hsa049170.58681616
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.57452774
73Viral carcinogenesis_Homo sapiens_hsa052030.56814879
74Caffeine metabolism_Homo sapiens_hsa002320.54911261
75Amoebiasis_Homo sapiens_hsa051460.54563976
76VEGF signaling pathway_Homo sapiens_hsa043700.52668938
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52418797
78GnRH signaling pathway_Homo sapiens_hsa049120.49654215
79Small cell lung cancer_Homo sapiens_hsa052220.47501372
80Choline metabolism in cancer_Homo sapiens_hsa052310.45475969
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45205031
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.44282038
83Endometrial cancer_Homo sapiens_hsa052130.44107972
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41248652
85HIF-1 signaling pathway_Homo sapiens_hsa040660.40372714
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40355022
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39558559
88Prion diseases_Homo sapiens_hsa050200.38465365
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.37351845
90HTLV-I infection_Homo sapiens_hsa051660.36838542
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34773662
92Endocytosis_Homo sapiens_hsa041440.34118317
93Inositol phosphate metabolism_Homo sapiens_hsa005620.33487816
94Collecting duct acid secretion_Homo sapiens_hsa049660.33261109
95Regulation of autophagy_Homo sapiens_hsa041400.32825962
96Bladder cancer_Homo sapiens_hsa052190.31820894
97Non-small cell lung cancer_Homo sapiens_hsa052230.29959627
98Rap1 signaling pathway_Homo sapiens_hsa040150.28431381
99p53 signaling pathway_Homo sapiens_hsa041150.28272295
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26291622
101Colorectal cancer_Homo sapiens_hsa052100.25975104
102Insulin resistance_Homo sapiens_hsa049310.22986213
103Systemic lupus erythematosus_Homo sapiens_hsa053220.22212801
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22163509
105MAPK signaling pathway_Homo sapiens_hsa040100.22000690
106Dorso-ventral axis formation_Homo sapiens_hsa043200.21451968
107mTOR signaling pathway_Homo sapiens_hsa041500.21050341
108FoxO signaling pathway_Homo sapiens_hsa040680.20483001
109Proteoglycans in cancer_Homo sapiens_hsa052050.19921843
110Type II diabetes mellitus_Homo sapiens_hsa049300.16737490
111ABC transporters_Homo sapiens_hsa020100.16201394
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15690553
113MicroRNAs in cancer_Homo sapiens_hsa052060.15614552
114Sphingolipid metabolism_Homo sapiens_hsa006000.14206550
115Adherens junction_Homo sapiens_hsa045200.13876460

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