THG1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)8.80961799
2regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)8.49612468
3ribosomal small subunit biogenesis (GO:0042274)8.10656475
4postsynaptic membrane organization (GO:0001941)7.69874690
5anterior/posterior axis specification, embryo (GO:0008595)7.61600096
6viral transcription (GO:0019083)7.61260531
7translational termination (GO:0006415)7.17305476
8presynaptic membrane organization (GO:0097090)6.99285253
9generation of neurons (GO:0048699)6.86539001
10interferon-gamma production (GO:0032609)6.43239156
11Golgi to endosome transport (GO:0006895)6.33870436
12ribosomal large subunit biogenesis (GO:0042273)6.29168884
13regulation of metalloenzyme activity (GO:0048552)6.22556797
14protein heterotetramerization (GO:0051290)6.15259369
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.00635133
16regulation of stem cell maintenance (GO:2000036)5.99755605
17protein targeting to ER (GO:0045047)5.94986808
18cotranslational protein targeting to membrane (GO:0006613)5.93303013
19translational elongation (GO:0006414)5.72728517
20neurotransmitter-gated ion channel clustering (GO:0072578)5.70664393
21establishment of protein localization to endoplasmic reticulum (GO:0072599)5.68084209
22protein localization to endoplasmic reticulum (GO:0070972)5.59412502
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.39663577
24cellular protein complex disassembly (GO:0043624)5.38623167
25viral life cycle (GO:0019058)5.20750864
26translational initiation (GO:0006413)5.18904983
27mature B cell differentiation (GO:0002335)5.06463218
28proteasome assembly (GO:0043248)4.89624732
29ribosomal small subunit assembly (GO:0000028)4.76814283
30maturation of SSU-rRNA (GO:0030490)4.75066096
31response to folic acid (GO:0051593)4.74335315
32establishment of protein localization to mitochondrial membrane (GO:0090151)4.66225096
33protein complex disassembly (GO:0043241)4.63911107
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.60651453
35positive regulation of synaptic transmission, GABAergic (GO:0032230)4.60524604
36negative regulation of inclusion body assembly (GO:0090084)4.52744124
37adult heart development (GO:0007512)4.51631219
38macromolecular complex disassembly (GO:0032984)4.33251438
39positive regulation of neurotransmitter secretion (GO:0001956)4.31086351
40omega-hydroxylase P450 pathway (GO:0097267)4.23716899
41regulation of ruffle assembly (GO:1900027)4.17931603
42ATP synthesis coupled proton transport (GO:0015986)4.14831099
43energy coupled proton transport, down electrochemical gradient (GO:0015985)4.14831099
44neuron cell-cell adhesion (GO:0007158)4.08595385
45regulation of T-helper 2 cell differentiation (GO:0045628)4.08539917
46DNA deamination (GO:0045006)4.00172554
47protein targeting to membrane (GO:0006612)3.99187821
48melanin metabolic process (GO:0006582)3.96930788
49rRNA modification (GO:0000154)3.94754564
50positive regulation of protein kinase C signaling (GO:0090037)3.88881538
51DNA damage response, detection of DNA damage (GO:0042769)3.88404261
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.82736485
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.82675714
54chaperone-mediated protein transport (GO:0072321)3.81719827
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.77355259
56ribonucleoprotein complex biogenesis (GO:0022613)3.76280704
57cullin deneddylation (GO:0010388)3.76055066
58chromatin remodeling at centromere (GO:0031055)3.72982738
59CENP-A containing nucleosome assembly (GO:0034080)3.68875289
60pseudouridine synthesis (GO:0001522)3.68440198
61vesicle targeting (GO:0006903)3.68420171
62DNA double-strand break processing (GO:0000729)3.66852422
63positive regulation of response to tumor cell (GO:0002836)3.64506656
64positive regulation of immune response to tumor cell (GO:0002839)3.64506656
65regulation of immune response to tumor cell (GO:0002837)3.64506656
66regulation of response to tumor cell (GO:0002834)3.64506656
67nuclear-transcribed mRNA catabolic process (GO:0000956)3.60744450
68mitochondrial respiratory chain complex assembly (GO:0033108)3.59384294
69membrane assembly (GO:0071709)3.59368463
70mRNA catabolic process (GO:0006402)3.58778964
71DNA replication initiation (GO:0006270)3.53851243
72regulation of T-helper 1 cell differentiation (GO:0045625)3.53026120
73maturation of 5.8S rRNA (GO:0000460)3.51777025
74protein complex biogenesis (GO:0070271)3.51746111
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50930506
76protein localization to synapse (GO:0035418)3.47659556
77RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.44952200
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43341045
79negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.42119507
80negative regulation of T-helper cell differentiation (GO:0045623)3.42119507
81mitochondrial respiratory chain complex I assembly (GO:0032981)3.40740231
82NADH dehydrogenase complex assembly (GO:0010257)3.40740231
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40740231
84negative regulation of alpha-beta T cell differentiation (GO:0046639)3.40021073
85translation (GO:0006412)3.38938338
86regulation of mitochondrial translation (GO:0070129)3.36445331
87telomere maintenance via semi-conservative replication (GO:0032201)3.36412308
88rRNA methylation (GO:0031167)3.35790333
89spliceosomal snRNP assembly (GO:0000387)3.35607905
90respiratory chain complex IV assembly (GO:0008535)3.34088204
91water-soluble vitamin biosynthetic process (GO:0042364)3.34062272
92DNA strand elongation involved in DNA replication (GO:0006271)3.32721912
93melanin biosynthetic process (GO:0042438)3.31980674
94RNA catabolic process (GO:0006401)3.31514250
95sulfate transmembrane transport (GO:1902358)3.30917233
96protein K63-linked deubiquitination (GO:0070536)3.30881976
97ncRNA 3-end processing (GO:0043628)3.30367039
98positive regulation of osteoclast differentiation (GO:0045672)3.29427635
99negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.27731837
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26804849
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26487304
102cellular response to nitric oxide (GO:0071732)3.25433208
103positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.25303525
104positive regulation of natural killer cell mediated immunity (GO:0002717)3.25303525
105DNA catabolic process, exonucleolytic (GO:0000738)3.23763855
106protein deneddylation (GO:0000338)3.23576550
107glycine metabolic process (GO:0006544)3.23191508
108inner mitochondrial membrane organization (GO:0007007)3.20563824
109mitochondrial RNA metabolic process (GO:0000959)3.20387669
110termination of RNA polymerase III transcription (GO:0006386)3.20309267
111transcription elongation from RNA polymerase III promoter (GO:0006385)3.20309267
112cellular component biogenesis (GO:0044085)3.20059595
113DNA strand elongation (GO:0022616)3.19905279
114respiratory electron transport chain (GO:0022904)3.19583250
115positive regulation of systemic arterial blood pressure (GO:0003084)3.19082618
116positive regulation of dendritic spine development (GO:0060999)3.18588305
117electron transport chain (GO:0022900)3.18138326
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15439832
119negative regulation of ligase activity (GO:0051352)3.15439832
120formation of translation preinitiation complex (GO:0001731)3.15170910
121regulation of protein heterodimerization activity (GO:0043497)3.15078913
122anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14487237
123replication fork processing (GO:0031297)3.13686840
124regulation of protein kinase C signaling (GO:0090036)3.12842416
125regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.12231450
126regulation of natural killer cell mediated immunity (GO:0002715)3.12231450
127positive regulation of histone methylation (GO:0031062)3.11443340
128histone exchange (GO:0043486)3.10071789
129peptidyl-histidine modification (GO:0018202)3.07526400
130recombinational repair (GO:0000725)3.05885314
131positive regulation of neurotransmitter transport (GO:0051590)3.05855715
132positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05296019
133cellular response to exogenous dsRNA (GO:0071360)3.03197210
134ribosome biogenesis (GO:0042254)3.03083627
135double-strand break repair via homologous recombination (GO:0000724)3.03059004
136protein targeting to mitochondrion (GO:0006626)3.01900270
137DNA replication checkpoint (GO:0000076)3.01690258
138ribosome assembly (GO:0042255)3.01481018
139purine nucleobase biosynthetic process (GO:0009113)3.01254117
1407-methylguanosine mRNA capping (GO:0006370)2.99787250
141interferon-gamma secretion (GO:0072643)2.99560288
142cytochrome complex assembly (GO:0017004)2.99116648
143signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98572563
144signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98572563
145signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98572563
146interkinetic nuclear migration (GO:0022027)2.97971851
147DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97649025
148negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97518909
149nucleobase biosynthetic process (GO:0046112)2.95192255
150establishment of protein localization to mitochondrion (GO:0072655)2.93779015
151telencephalon development (GO:0021537)2.93528542
152intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92407736
153signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92407736
154phosphatidylinositol phosphorylation (GO:0046854)2.92106308
155establishment of integrated proviral latency (GO:0075713)2.92074149
156sulfate transport (GO:0008272)2.91062360
1577-methylguanosine RNA capping (GO:0009452)2.91044859
158RNA capping (GO:0036260)2.91044859
159establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.90627325
160protein-cofactor linkage (GO:0018065)2.89466129
161telomere maintenance via recombination (GO:0000722)2.88922196
162rRNA processing (GO:0006364)2.88321559
163signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88253077
164signal transduction involved in DNA damage checkpoint (GO:0072422)2.88253077
165protein localization to mitochondrion (GO:0070585)2.87944064
166signal transduction involved in cell cycle checkpoint (GO:0072395)2.87027198
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86980433
168protein K6-linked ubiquitination (GO:0085020)2.86596157
169regulation of cellular amino acid metabolic process (GO:0006521)2.85721548
170* ncRNA metabolic process (GO:0034660)2.85236053
171cellular modified amino acid catabolic process (GO:0042219)2.82333482
172regulation of respiratory system process (GO:0044065)2.81197716
173positive regulation of membrane potential (GO:0045838)2.79662961
174regulation of inclusion body assembly (GO:0090083)2.79348955
175rRNA metabolic process (GO:0016072)2.76967686
176regulation of histone H3-K27 methylation (GO:0061085)11.5780812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.74303203
2IRF1_19129219_ChIP-ChIP_H3396_Human5.33788016
3E2F7_22180533_ChIP-Seq_HELA_Human4.88622726
4* MYC_18555785_ChIP-Seq_MESCs_Mouse4.32187305
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.37336296
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.35485157
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.35485157
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.35485157
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23324079
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.11500716
11ELK1_19687146_ChIP-ChIP_HELA_Human3.05500323
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86345239
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84348219
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77659131
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55647405
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.54220640
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.48113691
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.43653855
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36966314
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.33763050
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.22620351
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17468411
23VDR_23849224_ChIP-Seq_CD4+_Human2.17058848
24TTF2_22483619_ChIP-Seq_HELA_Human2.13108291
25PADI4_21655091_ChIP-ChIP_MCF-7_Human2.09514079
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.09288718
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06615592
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04123161
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03924099
30* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02346061
31PKCTHETA_26484144_Chip-Seq_BREAST_Human1.99887636
32ZNF274_21170338_ChIP-Seq_K562_Hela1.96563283
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95216962
34MAF_26560356_Chip-Seq_TH1_Human1.87505067
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.85860821
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85353571
37GABP_19822575_ChIP-Seq_HepG2_Human1.85159358
38XRN2_22483619_ChIP-Seq_HELA_Human1.83141590
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80873923
40* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76360260
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75459494
42* ELK1_22589737_ChIP-Seq_MCF10A_Human1.74481229
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64069988
44FOXP3_21729870_ChIP-Seq_TREG_Human1.63760094
45MYC_18940864_ChIP-ChIP_HL60_Human1.61569605
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61567600
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.59950364
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.59382341
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58122068
50EWS_26573619_Chip-Seq_HEK293_Human1.57583207
51MYC_22102868_ChIP-Seq_BL_Human1.54939479
52SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.54252508
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52767083
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.51798608
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50913653
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.50434855
57* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50388248
58MYB_26560356_Chip-Seq_TH2_Human1.49327369
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48202298
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48145159
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.45348036
62UTX_26944678_Chip-Seq_JUKART_Human1.44738279
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44232053
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42455531
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.42304364
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39593042
67FUS_26573619_Chip-Seq_HEK293_Human1.39543531
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.38150489
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36385200
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35811257
71DCP1A_22483619_ChIP-Seq_HELA_Human1.34537007
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.33686623
73* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30589688
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28976166
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27290953
76TAF15_26573619_Chip-Seq_HEK293_Human1.26968937
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25303468
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25008460
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22402283
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22161443
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20357950
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19950874
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14366479
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13868382
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13334644
86* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12668556
87TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12090594
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11801039
89MAF_26560356_Chip-Seq_TH2_Human1.11515799
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11055262
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10569495
92VDR_22108803_ChIP-Seq_LS180_Human1.08973425
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08925171
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08224538
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07471504
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05807475
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.05060563
98ELF5_23300383_ChIP-Seq_T47D_Human1.04709146
99TP53_22573176_ChIP-Seq_HFKS_Human1.03458793
100EZH2_22144423_ChIP-Seq_EOC_Human1.02666703
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02582391
102STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99854673
103IGF1R_20145208_ChIP-Seq_DFB_Human0.99801139
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98960268
105PU_27001747_Chip-Seq_BMDM_Mouse0.98683488
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96986633
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96901274
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95788151
109* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95780899
110SPI1_23547873_ChIP-Seq_NB4_Human0.94922740
111MYB_26560356_Chip-Seq_TH1_Human0.93554076
112EGR1_19374776_ChIP-ChIP_THP-1_Human0.92366267
113STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92322410
114CIITA_25753668_ChIP-Seq_RAJI_Human0.91184563
115AR_21909140_ChIP-Seq_LNCAP_Human0.90268231
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89417786
117ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89244976
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89085922
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.89063889
120NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88876875
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.87547844
122NANOG_16153702_ChIP-ChIP_HESCs_Human0.87213128
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85506251
124KDM5A_27292631_Chip-Seq_BREAST_Human0.81937430
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81239385
126NMYC_18555785_Chip-Seq_ESCs_Mouse0.80206507
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80194837
128RUNX1_27457419_Chip-Seq_LIVER_Mouse0.79628679
129MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79390788
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79303747
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78610500
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78478602
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77873692
134* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77411766
135* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77206921
136SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75765546
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75462880
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.74666830
139VDR_24763502_ChIP-Seq_THP-1_Human0.74551223
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72870969
141AR_20517297_ChIP-Seq_VCAP_Human0.70322038
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69543267
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.69543267
144CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.68833280
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.63812647
146ERG_20517297_ChIP-Seq_VCAP_Human0.62760654

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.88860940
2MP0003880_abnormal_central_pattern6.87621299
3MP0009379_abnormal_foot_pigmentation6.37791661
4MP0002009_preneoplasia4.72961673
5MP0006292_abnormal_olfactory_placode4.20649919
6MP0004381_abnormal_hair_follicle4.10416082
7MP0001188_hyperpigmentation4.07093011
8MP0005409_darkened_coat_color3.84710621
9MP0009697_abnormal_copulation2.94468169
10MP0003111_abnormal_nucleus_morphology2.51829811
11MP0005174_abnormal_tail_pigmentation2.39664917
12MP0003806_abnormal_nucleotide_metabolis2.38194910
13MP0003786_premature_aging2.34888227
14MP0008057_abnormal_DNA_replication2.32578350
15MP0008007_abnormal_cellular_replicative2.27436588
16MP0006072_abnormal_retinal_apoptosis2.14475130
17MP0002102_abnormal_ear_morphology2.10217679
18MP0001293_anophthalmia1.98786413
19MP0000566_synostosis1.88648213
20MP0003763_abnormal_thymus_physiology1.88446867
21MP0003868_abnormal_feces_composition1.87607418
22MP0003938_abnormal_ear_development1.85659752
23MP0006276_abnormal_autonomic_nervous1.85521880
24MP0003693_abnormal_embryo_hatching1.84774283
25MP0008877_abnormal_DNA_methylation1.81782249
26MP0006036_abnormal_mitochondrial_physio1.76252868
27MP0000858_altered_metastatic_potential1.73238725
28MP0004957_abnormal_blastocyst_morpholog1.69425243
29MP0003119_abnormal_digestive_system1.67853547
30MP0003186_abnormal_redox_activity1.67394421
31MP0000015_abnormal_ear_pigmentation1.67307904
32MP0000490_abnormal_crypts_of1.66350810
33MP0006035_abnormal_mitochondrial_morpho1.52360667
34MP0008995_early_reproductive_senescence1.46950028
35MP0009333_abnormal_splenocyte_physiolog1.45387637
36MP0002163_abnormal_gland_morphology1.39551498
37MP0005084_abnormal_gallbladder_morpholo1.38799285
38MP0002234_abnormal_pharynx_morphology1.37312635
39MP0002638_abnormal_pupillary_reflex1.33971880
40MP0002166_altered_tumor_susceptibility1.32081510
41MP0003866_abnormal_defecation1.32061309
42MP0002282_abnormal_trachea_morphology1.30903531
43MP0005248_abnormal_Harderian_gland1.30091092
44MP0002254_reproductive_system_inflammat1.27448367
45MP0005394_taste/olfaction_phenotype1.26829825
46MP0005499_abnormal_olfactory_system1.26829825
47MP0003718_maternal_effect1.25058872
48MP0001764_abnormal_homeostasis1.24156386
49MP0002177_abnormal_outer_ear1.23977578
50MP0010094_abnormal_chromosome_stability1.23963866
51MP0005646_abnormal_pituitary_gland1.23671284
52MP0002138_abnormal_hepatobiliary_system1.23474305
53MP0005253_abnormal_eye_physiology1.20591656
54MP0001968_abnormal_touch/_nociception1.19321344
55MP0005257_abnormal_intraocular_pressure1.17785176
56MP0002837_dystrophic_cardiac_calcinosis1.17333449
57MP0000383_abnormal_hair_follicle1.15893921
58MP0001929_abnormal_gametogenesis1.15640343
59MP0000427_abnormal_hair_cycle1.13339432
60MP0008789_abnormal_olfactory_epithelium1.12515728
61MP0002751_abnormal_autonomic_nervous1.10759647
62MP0000372_irregular_coat_pigmentation1.09071996
63MP0005410_abnormal_fertilization1.08487202
64MP0002396_abnormal_hematopoietic_system1.07039506
65MP0002006_tumorigenesis1.05900809
66MP0010030_abnormal_orbit_morphology1.03974904
67MP0001919_abnormal_reproductive_system1.02814490
68MP0001145_abnormal_male_reproductive1.01264348
69MP0001529_abnormal_vocalization1.01250439
70MP0000653_abnormal_sex_gland1.01188492
71MP0003646_muscle_fatigue1.00609611
72MP0008058_abnormal_DNA_repair1.00429799
73MP0001986_abnormal_taste_sensitivity1.00174659
74MP0002277_abnormal_respiratory_mucosa0.99591058
75MP0008961_abnormal_basal_metabolism0.99376536
76MP0010307_abnormal_tumor_latency0.98814646
77MP0005551_abnormal_eye_electrophysiolog0.97986946
78MP0001119_abnormal_female_reproductive0.96685636
79MP0003567_abnormal_fetal_cardiomyocyte0.95906430
80MP0001697_abnormal_embryo_size0.95315428
81MP0002095_abnormal_skin_pigmentation0.94319211
82MP0004147_increased_porphyrin_level0.93744846
83MP0001286_abnormal_eye_development0.93436890
84MP0008872_abnormal_physiological_respon0.93344927
85MP0003453_abnormal_keratinocyte_physiol0.93244557
86MP0000313_abnormal_cell_death0.93101917
87MP0000358_abnormal_cell_content/0.92635258
88MP0000647_abnormal_sebaceous_gland0.92181611
89MP0008932_abnormal_embryonic_tissue0.87836976
90MP0000049_abnormal_middle_ear0.87210155
91MP0005379_endocrine/exocrine_gland_phen0.85746850
92MP0003448_altered_tumor_morphology0.85044167
93MP0000681_abnormal_thyroid_gland0.84350475
94MP0002249_abnormal_larynx_morphology0.82247082
95MP0000465_gastrointestinal_hemorrhage0.82165459
96MP0000703_abnormal_thymus_morphology0.81975154
97MP0001485_abnormal_pinna_reflex0.81832432
98MP0005391_vision/eye_phenotype0.81280299
99MP0001661_extended_life_span0.81002295
100MP0003698_abnormal_male_reproductive0.79694521
101MP0001765_abnormal_ion_homeostasis0.79201099
102MP0000613_abnormal_salivary_gland0.78978385
103MP0001340_abnormal_eyelid_morphology0.78308987
104MP0003283_abnormal_digestive_organ0.77015801
105MP0002084_abnormal_developmental_patter0.76455319
106MP0009053_abnormal_anal_canal0.76346389
107MP0005408_hypopigmentation0.75354570
108MP0000350_abnormal_cell_proliferation0.74032843
109MP0008260_abnormal_autophagy0.73326433
110MP0005671_abnormal_response_to0.73262518
111MP0002420_abnormal_adaptive_immunity0.73158963
112MP0004885_abnormal_endolymph0.72323078
113MP0001819_abnormal_immune_cell0.72129473
114MP0003315_abnormal_perineum_morphology0.71364427
115MP0002160_abnormal_reproductive_system0.70351875
116MP0001348_abnormal_lacrimal_gland0.70118821
117MP0008569_lethality_at_weaning0.69635664
118MP0003195_calcinosis0.69061755
119MP0005000_abnormal_immune_tolerance0.68946964
120MP0002111_abnormal_tail_morphology0.68817830
121MP0002398_abnormal_bone_marrow0.68230343
122MP0009672_abnormal_birth_weight0.67871720
123MP0010678_abnormal_skin_adnexa0.67650565
124MP0002085_abnormal_embryonic_tissue0.67408982
125MP0001800_abnormal_humoral_immune0.67078127
126MP0003941_abnormal_skin_development0.66260944
127MP0002233_abnormal_nose_morphology0.65753433
128MP0002938_white_spotting0.65458608
129MP0008875_abnormal_xenobiotic_pharmacok0.65316158
130MP0001663_abnormal_digestive_system0.64803007
131MP0003936_abnormal_reproductive_system0.63489214
132MP0001672_abnormal_embryogenesis/_devel0.63230180
133MP0005380_embryogenesis_phenotype0.63230180
134MP0002876_abnormal_thyroid_physiology0.63132400
135MP0001944_abnormal_pancreas_morphology0.62789665
136MP0003943_abnormal_hepatobiliary_system0.62141614
137MP0002019_abnormal_tumor_incidence0.60164984
138MP0002722_abnormal_immune_system0.59791181
139MP0001346_abnormal_lacrimal_gland0.59704086
140MP0002723_abnormal_immune_serum0.58789110
141MP0000716_abnormal_immune_system0.58770969
142MP0009785_altered_susceptibility_to0.58465484
143MP0005395_other_phenotype0.58271945
144MP0005075_abnormal_melanosome_morpholog0.57660337
145MP0002452_abnormal_antigen_presenting0.57610062
146MP0005636_abnormal_mineral_homeostasis0.56838365
147MP0005165_increased_susceptibility_to0.56583636
148MP0002557_abnormal_social/conspecific_i0.55508633
149MP0003077_abnormal_cell_cycle0.55397402
150MP0005389_reproductive_system_phenotype0.54374637
151MP0003123_paternal_imprinting0.52080316
152MP0009250_abnormal_appendicular_skeleto0.51781100
153MP0010155_abnormal_intestine_physiology0.51431007
154MP0000631_abnormal_neuroendocrine_gland0.50297691
155MP0005381_digestive/alimentary_phenotyp0.49695657
156MP0002429_abnormal_blood_cell0.49642283
157MP0002210_abnormal_sex_determination0.48306990
158MP0004142_abnormal_muscle_tone0.47161063
159MP0005025_abnormal_response_to0.46456381
160MP0003436_decreased_susceptibility_to0.46218155
161MP0003937_abnormal_limbs/digits/tail_de0.46101628
162MP0000689_abnormal_spleen_morphology0.45423092

Predicted human phenotypes

RankGene SetZ-score
1Pseudobulbar signs (HP:0002200)7.90720827
2Abnormal hemoglobin (HP:0011902)6.66902840
3Hyperactive renin-angiotensin system (HP:0000841)5.45014416
4Amelogenesis imperfecta (HP:0000705)5.20002965
5Macrocytic anemia (HP:0001972)5.06536793
6Abnormality of renin-angiotensin system (HP:0000847)4.82154622
7Decreased circulating renin level (HP:0003351)4.79220294
8Hyponatremia (HP:0002902)4.78543385
9Cone-rod dystrophy (HP:0000548)4.66518999
10Metabolic alkalosis (HP:0200114)4.47818991
11Abnormality of dental color (HP:0011073)4.40882816
12Reticulocytopenia (HP:0001896)4.39448192
13Increased hepatocellular lipid droplets (HP:0006565)4.13269207
14Abnormality of chloride homeostasis (HP:0011422)4.10244944
15Lipid accumulation in hepatocytes (HP:0006561)3.99034607
16Abnormality of cells of the erythroid lineage (HP:0012130)3.98887251
17Abnormal number of erythroid precursors (HP:0012131)3.94412394
18Intellectual disability, progressive (HP:0006887)3.84425015
19Mitochondrial inheritance (HP:0001427)3.84365798
20Abnormality of sodium homeostasis (HP:0010931)3.83103430
21Acute necrotizing encephalopathy (HP:0006965)3.78698746
22Progressive external ophthalmoplegia (HP:0000590)3.72077015
23Increased CSF lactate (HP:0002490)3.68426657
24Acute encephalopathy (HP:0006846)3.59794340
25Testicular atrophy (HP:0000029)3.56622378
26Hyperglycinemia (HP:0002154)3.56449974
27Microglossia (HP:0000171)3.56100300
28Optic disc pallor (HP:0000543)3.54608017
29Excessive salivation (HP:0003781)3.52478451
30Drooling (HP:0002307)3.52478451
31Abnormal mitochondria in muscle tissue (HP:0008316)3.46881598
32Hepatocellular necrosis (HP:0001404)3.40750592
33Pallor (HP:0000980)3.35007856
34Pancreatic cysts (HP:0001737)3.30529732
35Hepatic necrosis (HP:0002605)3.24240921
36Renal Fanconi syndrome (HP:0001994)3.20132955
37Progressive muscle weakness (HP:0003323)3.19841676
38Reduced antithrombin III activity (HP:0001976)3.17097863
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.14581451
40Progressive macrocephaly (HP:0004481)3.12096626
41Sex reversal (HP:0012245)3.10441374
42Abnormal sex determination (HP:0012244)3.10441374
43Chromsome breakage (HP:0040012)3.09160757
44Stomatitis (HP:0010280)3.08508886
45Nonprogressive disorder (HP:0003680)3.05544410
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99152788
47Pancreatic fibrosis (HP:0100732)2.99105165
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96571587
49Focal motor seizures (HP:0011153)2.91989065
50Vacuolated lymphocytes (HP:0001922)2.89145591
51Meckel diverticulum (HP:0002245)2.88937316
52Abnormality of the ileum (HP:0001549)2.88341443
53Increased intramyocellular lipid droplets (HP:0012240)2.87620035
54True hermaphroditism (HP:0010459)2.86930882
55Increased serum lactate (HP:0002151)2.86461634
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.82611932
57Congenital, generalized hypertrichosis (HP:0004540)2.77606208
58Triphalangeal thumb (HP:0001199)2.77027933
59Trismus (HP:0000211)2.76447769
60Multiple enchondromatosis (HP:0005701)2.74820767
61Abnormality of chromosome stability (HP:0003220)2.74524710
62Adducted thumb (HP:0001181)2.74452804
63Cerebral edema (HP:0002181)2.68971849
64Molar tooth sign on MRI (HP:0002419)2.67700216
65Abnormality of midbrain morphology (HP:0002418)2.67700216
66Abnormality of the preputium (HP:0100587)2.66144795
67Glomerulonephritis (HP:0000099)2.64368739
68Alkalosis (HP:0001948)2.59595958
69Lactic acidosis (HP:0003128)2.59428331
70Nephronophthisis (HP:0000090)2.58723281
71Progressive inability to walk (HP:0002505)2.56239301
72Hyperaldosteronism (HP:0000859)2.54982227
73Absent thumb (HP:0009777)2.51240457
74Hyperglycinuria (HP:0003108)2.48273389
75Capillary hemangiomas (HP:0005306)2.45168314
76Hypoplasia of the pons (HP:0012110)2.44525483
77Leiomyosarcoma (HP:0100243)2.41526415
78Uterine leiomyosarcoma (HP:0002891)2.41526415
79Abnormality of the pons (HP:0007361)2.41320123
80Neonatal onset (HP:0003623)2.40191339
81Peripheral hypomyelination (HP:0007182)2.39720978
82Bilateral microphthalmos (HP:0007633)2.38783407
83Increased muscle lipid content (HP:0009058)2.37543603
84Obstructive sleep apnea (HP:0002870)2.36888687
85Abnormality of the phalanges of the hallux (HP:0010057)2.36801167
86Abdominal situs inversus (HP:0003363)2.35973350
87Abnormality of abdominal situs (HP:0011620)2.35973350
88Abnormality of secondary sexual hair (HP:0009888)2.35320897
89Abnormality of the axillary hair (HP:0100134)2.35320897
90Ulnar claw (HP:0001178)2.33062855
91Exertional dyspnea (HP:0002875)2.31959028
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30064990
93Gliosis (HP:0002171)2.29934604
94Small intestinal stenosis (HP:0012848)2.22631791
95Duodenal stenosis (HP:0100867)2.22631791
96Aplasia/hypoplasia of the uterus (HP:0008684)2.21541009
97Hypoplasia of the radius (HP:0002984)2.20464700
98Concave nail (HP:0001598)2.20007416
99Abnormal drinking behavior (HP:0030082)2.19589740
100Polydipsia (HP:0001959)2.19589740
101Abnormality of the renal medulla (HP:0100957)2.19292686
102Cheilitis (HP:0100825)2.18050800
103Respiratory failure (HP:0002878)2.17964961
104Abnormality of the renal cortex (HP:0011035)2.17370634
105Impulsivity (HP:0100710)2.16509025
106Bladder carcinoma (HP:0002862)2.16314387
107Bladder neoplasm (HP:0009725)2.16314387
108Colon cancer (HP:0003003)2.15918108
109Adrenal overactivity (HP:0002717)2.15103384
1103-Methylglutaconic aciduria (HP:0003535)2.14672775
111Methylmalonic aciduria (HP:0012120)2.14400879
112Rhabdomyosarcoma (HP:0002859)2.14104053
113Sclerocornea (HP:0000647)2.13523733
114Type I transferrin isoform profile (HP:0003642)2.13235504
115Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.12189625
116Abnormality of salivation (HP:0100755)2.11355184
117Recurrent cutaneous fungal infections (HP:0011370)2.11258035
118Chronic mucocutaneous candidiasis (HP:0002728)2.11258035
119Pendular nystagmus (HP:0012043)2.10916992
120Sloping forehead (HP:0000340)2.10338141
121Generalized myoclonic seizures (HP:0002123)2.09513192
122Sensory axonal neuropathy (HP:0003390)2.09363305
123Methylmalonic acidemia (HP:0002912)2.09023804
124Transitional cell carcinoma of the bladder (HP:0006740)2.06962867
125Restlessness (HP:0000711)2.06544617
126Thyroid-stimulating hormone excess (HP:0002925)2.03264570
127Lethargy (HP:0001254)2.02795163
128Pancytopenia (HP:0001876)2.00927115
129Abnormality of alanine metabolism (HP:0010916)2.00817670
130Hyperalaninemia (HP:0003348)2.00817670
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00817670
132Optic nerve hypoplasia (HP:0000609)1.98966132
133Cortical visual impairment (HP:0100704)1.98675602
134Bile duct proliferation (HP:0001408)1.98627131
135Abnormal biliary tract physiology (HP:0012439)1.98627131
136Respiratory difficulties (HP:0002880)1.97044192
137Abnormal number of incisors (HP:0011064)1.96036918
138Exercise intolerance (HP:0003546)1.95338569
139Oligodactyly (HP:0012165)1.94897110
140Abnormal lung lobation (HP:0002101)1.94851014
141Medial flaring of the eyebrow (HP:0010747)1.94817068
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94632800
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94632800
144Anhidrosis (HP:0000970)1.94437599
145Birth length less than 3rd percentile (HP:0003561)1.91788182
146Abnormality of renal resorption (HP:0011038)1.91706468
147Cleft eyelid (HP:0000625)1.91596804
148Abnormality of the duodenum (HP:0002246)1.91212238
149Hypoplasia of the uterus (HP:0000013)1.91178884
150Megaloblastic anemia (HP:0001889)1.90743294
151Clubbing of toes (HP:0100760)1.89604159
152Abnormality of the labia minora (HP:0012880)1.89306128
153Spastic tetraplegia (HP:0002510)1.88159005
154Congenital stationary night blindness (HP:0007642)1.87495282
155Dysphonia (HP:0001618)1.87373240
156Microvesicular hepatic steatosis (HP:0001414)1.86456218
157Thick lower lip vermilion (HP:0000179)1.86393775
158Meningitis (HP:0001287)1.86156020
159Abnormality of serum amino acid levels (HP:0003112)1.84761630
160Malnutrition (HP:0004395)1.84164077
161Hyperparathyroidism (HP:0000843)1.83996060
162Chronic obstructive pulmonary disease (HP:0006510)1.83956625
163Obstructive lung disease (HP:0006536)1.83956625
164Degeneration of anterior horn cells (HP:0002398)1.83282732
165Abnormality of the anterior horn cell (HP:0006802)1.83282732
166Renal cortical cysts (HP:0000803)1.83036954
167Migraine (HP:0002076)1.82056711
168Aplasia/Hypoplasia of the spleen (HP:0010451)1.81027381
169Aplasia/Hypoplasia of the tongue (HP:0010295)1.80009647
170Abdominal distention (HP:0003270)1.79976663
171Abnormality of methionine metabolism (HP:0010901)1.79734180
172Abnormality of the carotid arteries (HP:0005344)1.78968358
173Microcytic anemia (HP:0001935)1.78303898
174Abnormality of glycine metabolism (HP:0010895)1.78017519
175Abnormality of serine family amino acid metabolism (HP:0010894)1.78017519
176Horseshoe kidney (HP:0000085)1.77861564
177Chronic hepatic failure (HP:0100626)1.76723862
178Unilateral renal agenesis (HP:0000122)1.76571496
179Glycosuria (HP:0003076)1.74636421
180Abnormality of urine glucose concentration (HP:0011016)1.74636421
181Abnormality of the renal collecting system (HP:0004742)1.74453698
182Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73971760
183CNS demyelination (HP:0007305)1.73940256
184Asplenia (HP:0001746)1.70618548
185Abnormality of DNA repair (HP:0003254)1.69927751
186Abnormal glycosylation (HP:0012345)1.68412097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CLK16.46143076
2STK385.74729975
3PRKD25.38918760
4CASK5.06509824
5TSSK64.33248096
6VRK24.20784118
7NLK3.95974206
8NME23.40748026
9STK163.39845834
10MAP4K23.25956248
11TLK13.20507985
12ZAK2.98598899
13NUAK12.89021672
14EIF2AK12.15270552
15GRK62.14161586
16STK112.07338400
17PLK41.90257039
18MAPK151.86067812
19MST41.83676259
20PLK31.81082312
21HIPK21.81009534
22UHMK11.76863977
23PBK1.76242026
24NEK11.74875841
25BRSK21.74354134
26FRK1.69529886
27TTK1.67947183
28TAF11.67031968
29IRAK31.66512540
30FGR1.60818087
31SRPK11.49120161
32TXK1.42837900
33BMPR1B1.37798265
34IRAK41.35349983
35PLK11.33848464
36PASK1.30421624
37EIF2AK31.25641903
38YES11.25392047
39ACVR1B1.23362433
40BUB11.22875086
41VRK11.20842717
42ATR1.17608916
43WNK31.16204821
44CSNK1G11.13239201
45CHEK21.11391039
46MKNK21.11336240
47MAP4K11.09726826
48GRK11.07608883
49PNCK1.06031377
50ZAP701.04755704
51TRIM281.04144222
52IRAK11.04126199
53IRAK21.01301954
54CCNB10.98150269
55TESK20.95855583
56ADRBK20.95769493
57PIM10.95343134
58AURKB0.93388857
59SGK20.92123091
60PDK20.84115510
61PRKD10.83352437
62GRK70.83170717
63RPS6KA40.80811977
64DYRK30.79748173
65TNIK0.75706679
66DYRK1B0.73963033
67STK100.73867258
68TGFBR10.73678501
69NEK20.72841520
70CDK80.70532301
71PLK20.70334675
72MAP3K120.67970121
73PIM20.64491083
74BRSK10.63915947
75CDK40.63695834
76BCKDK0.63597960
77ATM0.62912844
78OXSR10.62197670
79CHEK10.60655827
80IKBKB0.59807653
81CSNK1G30.59058058
82SGK4940.57746111
83SGK2230.57746111
84CAMK2B0.56741616
85EIF2AK20.56644176
86ERBB30.56277532
87DYRK1A0.55311158
88WEE10.54962994
89INSRR0.54120787
90NME10.52454060
91PAK10.50167370
92CSK0.49458644
93STK38L0.48301218
94BLK0.44568727
95STK30.44482540
96MKNK10.43672681
97TGFBR20.41898032
98CSNK1G20.41070428
99SGK30.40989002
100MAPKAPK50.40892109
101DYRK20.38406804
102CDK60.37821253
103CSNK1A1L0.37810620
104ADRBK10.37500881
105FLT30.37473823
106STK390.36266180
107AURKA0.33648719
108MAP3K10.33405592
109MAP3K110.32870347
110PINK10.32864198
111CDK190.32313864
112CAMKK20.32131805
113STK40.31885602
114CAMK2A0.31726196
115ALK0.31483392
116TEC0.29717535
117GSK3A0.29581302
118CDK20.29348989
119FES0.28827489
120CDK90.28720775
121CDK10.28639350
122CSNK1A10.28547318
123CDK70.25480313
124PRKCI0.25337538
125CDC70.25071905
126CSNK1E0.25019598
127GRK50.24902650
128MOS0.24301202
129MAPK100.24015552
130PHKG10.23680549
131PHKG20.23680549
132MAP3K40.23625768
133ABL20.23455880
134RPS6KC10.23407201
135RPS6KL10.23407201
136CDK30.22380103
137WNK40.21295861
138BMPR20.20552341
139TAOK30.19536630
140CSNK2A10.19526633
141BTK0.19352511
142NEK90.19318695
143EPHA30.18053444
144JAK20.17188490
145SYK0.16530903
146MAP2K70.16316969
147CSNK2A20.16248144
148LCK0.16185625
149LYN0.15770075
150PRKG20.12910537
151RIPK40.10669331
152RPS6KB20.10246623
153RPS6KA60.10070023
154RPS6KA50.08250657
155IKBKE0.08221759
156STK240.07989284
157ITK0.07226433
158MUSK0.07110395

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.85036829
2Thyroid cancer_Homo sapiens_hsa052164.48679689
3Spliceosome_Homo sapiens_hsa030403.44962292
4DNA replication_Homo sapiens_hsa030303.34657229
5Non-homologous end-joining_Homo sapiens_hsa034502.45128367
6Antigen processing and presentation_Homo sapiens_hsa046122.39613161
7Ether lipid metabolism_Homo sapiens_hsa005652.35734572
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24662430
9One carbon pool by folate_Homo sapiens_hsa006702.12411711
10RNA polymerase_Homo sapiens_hsa030202.08699584
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08174826
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07593990
13Graft-versus-host disease_Homo sapiens_hsa053321.83703639
14Protein export_Homo sapiens_hsa030601.81376349
15Homologous recombination_Homo sapiens_hsa034401.80952424
16Pyrimidine metabolism_Homo sapiens_hsa002401.76838507
17Basal cell carcinoma_Homo sapiens_hsa052171.74513473
18Acute myeloid leukemia_Homo sapiens_hsa052211.68833065
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68583196
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.66025320
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62854363
22Other glycan degradation_Homo sapiens_hsa005111.62156004
23Prostate cancer_Homo sapiens_hsa052151.62021061
24Propanoate metabolism_Homo sapiens_hsa006401.61314608
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.57571157
26Sulfur relay system_Homo sapiens_hsa041221.57507356
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54238887
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53305281
29Colorectal cancer_Homo sapiens_hsa052101.52693513
30Wnt signaling pathway_Homo sapiens_hsa043101.43697525
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42648472
32Measles_Homo sapiens_hsa051621.39953273
33Selenocompound metabolism_Homo sapiens_hsa004501.38316971
34Endometrial cancer_Homo sapiens_hsa052131.36944873
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29036890
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.26725558
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26651188
38Caffeine metabolism_Homo sapiens_hsa002321.22972419
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19811543
40Fanconi anemia pathway_Homo sapiens_hsa034601.17034079
41Primary immunodeficiency_Homo sapiens_hsa053401.15302583
42RNA transport_Homo sapiens_hsa030131.12944836
43Inositol phosphate metabolism_Homo sapiens_hsa005621.11857956
44Folate biosynthesis_Homo sapiens_hsa007901.11258906
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08963623
46Adherens junction_Homo sapiens_hsa045201.08542599
47Basal transcription factors_Homo sapiens_hsa030221.08149855
48Butanoate metabolism_Homo sapiens_hsa006501.08144763
49Nucleotide excision repair_Homo sapiens_hsa034201.07231544
50Melanogenesis_Homo sapiens_hsa049161.05848883
51Sphingolipid metabolism_Homo sapiens_hsa006001.05382385
52Proteasome_Homo sapiens_hsa030501.00658952
53mRNA surveillance pathway_Homo sapiens_hsa030151.00082321
54Mismatch repair_Homo sapiens_hsa034300.99164808
55Base excision repair_Homo sapiens_hsa034100.96996133
56Pyruvate metabolism_Homo sapiens_hsa006200.95330952
57Sulfur metabolism_Homo sapiens_hsa009200.93164798
58Epstein-Barr virus infection_Homo sapiens_hsa051690.92140846
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88433405
60Fatty acid elongation_Homo sapiens_hsa000620.82968498
61Cardiac muscle contraction_Homo sapiens_hsa042600.82664225
62Oxidative phosphorylation_Homo sapiens_hsa001900.81886098
63T cell receptor signaling pathway_Homo sapiens_hsa046600.78017777
64Pentose phosphate pathway_Homo sapiens_hsa000300.76966131
65Tryptophan metabolism_Homo sapiens_hsa003800.75885333
66Huntingtons disease_Homo sapiens_hsa050160.75192060
67Steroid biosynthesis_Homo sapiens_hsa001000.74223598
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69417837
69Long-term depression_Homo sapiens_hsa047300.68811125
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68548668
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68548464
72Mineral absorption_Homo sapiens_hsa049780.66823346
73Nicotine addiction_Homo sapiens_hsa050330.66739019
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65926989
75Nitrogen metabolism_Homo sapiens_hsa009100.65624068
76Purine metabolism_Homo sapiens_hsa002300.65125941
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.64478162
78Peroxisome_Homo sapiens_hsa041460.63961899
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61040905
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.60644268
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55183516
82Regulation of autophagy_Homo sapiens_hsa041400.53240702
83Choline metabolism in cancer_Homo sapiens_hsa052310.52856873
84Systemic lupus erythematosus_Homo sapiens_hsa053220.51639221
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.51562540
86Arachidonic acid metabolism_Homo sapiens_hsa005900.51105683
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49823374
88Cell cycle_Homo sapiens_hsa041100.49488266
89Prion diseases_Homo sapiens_hsa050200.48832851
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48643366
91Carbon metabolism_Homo sapiens_hsa012000.47701956
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46804922
93Parkinsons disease_Homo sapiens_hsa050120.46764079
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.46082634
95Pancreatic secretion_Homo sapiens_hsa049720.45329259
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.45044788
97p53 signaling pathway_Homo sapiens_hsa041150.43012200
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42520461
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40722743
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40488264
101RNA degradation_Homo sapiens_hsa030180.38411337
102Chemical carcinogenesis_Homo sapiens_hsa052040.36918356
103Biosynthesis of amino acids_Homo sapiens_hsa012300.36608784
104Herpes simplex infection_Homo sapiens_hsa051680.36520426
105Alzheimers disease_Homo sapiens_hsa050100.35532249
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.34725225
107Hippo signaling pathway_Homo sapiens_hsa043900.33221826
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32189052
109Oocyte meiosis_Homo sapiens_hsa041140.31320810
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30336396
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29837677
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29347152
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28982785
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28858094
115Olfactory transduction_Homo sapiens_hsa047400.28260245
116Fatty acid metabolism_Homo sapiens_hsa012120.27372847
117Linoleic acid metabolism_Homo sapiens_hsa005910.26845875
118Fatty acid degradation_Homo sapiens_hsa000710.25714942
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25637597
120N-Glycan biosynthesis_Homo sapiens_hsa005100.25215045
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24902680
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.24876426
123beta-Alanine metabolism_Homo sapiens_hsa004100.23931284
124Small cell lung cancer_Homo sapiens_hsa052220.23910376
125Asthma_Homo sapiens_hsa053100.23850624
126Pathways in cancer_Homo sapiens_hsa052000.23236071
127Tight junction_Homo sapiens_hsa045300.22683421
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21750698
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21616256
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21080344
131Hepatitis B_Homo sapiens_hsa051610.20756096
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20752361
133Hedgehog signaling pathway_Homo sapiens_hsa043400.20579321
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20465955
135Metabolic pathways_Homo sapiens_hsa011000.19954121
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19703474
137Long-term potentiation_Homo sapiens_hsa047200.18950947
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18692415
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.18382308
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.15459631
141Phototransduction_Homo sapiens_hsa047440.15446069
142Type I diabetes mellitus_Homo sapiens_hsa049400.15432588
143MAPK signaling pathway_Homo sapiens_hsa040100.15197045
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13276010
145Glutathione metabolism_Homo sapiens_hsa004800.13226216
146Retinol metabolism_Homo sapiens_hsa008300.08455633

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