THNSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.63171413
2presynaptic membrane assembly (GO:0097105)5.09025663
3regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.63981667
4postsynaptic membrane organization (GO:0001941)4.63647957
5vocalization behavior (GO:0071625)4.63276226
6protein localization to cilium (GO:0061512)4.57853356
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.55425258
8synapsis (GO:0007129)4.52049952
9synaptic vesicle exocytosis (GO:0016079)4.43947918
10presynaptic membrane organization (GO:0097090)4.38606448
11protein localization to synapse (GO:0035418)4.34684113
12cilium movement (GO:0003341)4.33209683
13epithelial cilium movement (GO:0003351)4.26330220
14response to pheromone (GO:0019236)4.15953693
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.15123277
16proteasome assembly (GO:0043248)4.13640052
17regulation of glutamate receptor signaling pathway (GO:1900449)4.01667359
18cilium or flagellum-dependent cell motility (GO:0001539)3.92390967
19glutamate secretion (GO:0014047)3.91817705
20regulation of synaptic vesicle exocytosis (GO:2000300)3.83944899
21resolution of meiotic recombination intermediates (GO:0000712)3.79968361
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.78371821
23intraciliary transport (GO:0042073)3.70689185
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.68440769
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.63830734
26neuron recognition (GO:0008038)3.62315226
27axonemal dynein complex assembly (GO:0070286)3.61384542
28axonal fasciculation (GO:0007413)3.60088623
29neurotransmitter-gated ion channel clustering (GO:0072578)3.55401591
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.54304752
31calcium ion-dependent exocytosis (GO:0017156)3.52941206
32regulation of meiosis I (GO:0060631)3.51498175
33behavioral response to cocaine (GO:0048148)3.51216909
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39570126
35water-soluble vitamin biosynthetic process (GO:0042364)3.39109710
36regulation of synaptic vesicle transport (GO:1902803)3.37444735
37regulation of cilium movement (GO:0003352)3.32722385
38synaptic vesicle maturation (GO:0016188)3.27877316
39meiotic chromosome segregation (GO:0045132)3.27247233
40chromosome organization involved in meiosis (GO:0070192)3.26445017
41DNA methylation involved in gamete generation (GO:0043046)3.24618633
42positive regulation of synapse assembly (GO:0051965)3.23942762
43innervation (GO:0060384)3.20048126
44synaptic transmission, glutamatergic (GO:0035249)3.19562835
45dendrite development (GO:0016358)3.18801077
46neuron-neuron synaptic transmission (GO:0007270)3.18608781
47male meiosis I (GO:0007141)3.17532167
48neuronal action potential propagation (GO:0019227)3.15861767
49regulation of respiratory system process (GO:0044065)3.12915052
50startle response (GO:0001964)3.12885487
51respiratory chain complex IV assembly (GO:0008535)3.12607172
52regulation of protein kinase A signaling (GO:0010738)3.11075590
53protein deneddylation (GO:0000338)3.10399585
54DNA double-strand break processing (GO:0000729)3.09395815
55regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05942301
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.05396510
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04193575
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03596167
59gamma-aminobutyric acid transport (GO:0015812)3.03502670
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02536047
61regulation of female receptivity (GO:0045924)3.02059634
62acrosome reaction (GO:0007340)3.00974756
63neurotransmitter secretion (GO:0007269)3.00161237
64chaperone-mediated protein transport (GO:0072321)2.98363788
65somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96781126
66somatic hypermutation of immunoglobulin genes (GO:0016446)2.96781126
67regulation of synaptic transmission, glutamatergic (GO:0051966)2.92151916
68CENP-A containing nucleosome assembly (GO:0034080)2.92100837
69glutamate receptor signaling pathway (GO:0007215)2.91976573
70aggressive behavior (GO:0002118)2.91577242
71DNA damage response, detection of DNA damage (GO:0042769)2.91261743
72membrane depolarization during action potential (GO:0086010)2.91103805
73regulation of mitochondrial translation (GO:0070129)2.90893378
74DNA replication checkpoint (GO:0000076)2.90798446
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90496746
76cilium assembly (GO:0042384)2.90047971
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89688005
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89688005
79chromatin remodeling at centromere (GO:0031055)2.89268073
80long-term synaptic potentiation (GO:0060291)2.88675942
81sensory perception of smell (GO:0007608)2.88004039
82ionotropic glutamate receptor signaling pathway (GO:0035235)2.87733835
83urinary tract smooth muscle contraction (GO:0014848)2.87186878
84synaptic vesicle endocytosis (GO:0048488)2.87116735
85protein polyglutamylation (GO:0018095)2.86995313
86S-adenosylmethionine metabolic process (GO:0046500)2.85017518
87positive regulation of membrane potential (GO:0045838)2.84864015
88cilium organization (GO:0044782)2.84480143
89mechanosensory behavior (GO:0007638)2.83836137
90rRNA modification (GO:0000154)2.83390293
91regulation of synapse structural plasticity (GO:0051823)2.82853797
92organelle disassembly (GO:1903008)2.81302890
93reciprocal meiotic recombination (GO:0007131)2.81079907
94reciprocal DNA recombination (GO:0035825)2.81079907
95sperm motility (GO:0030317)2.80730531
96regulation of centriole replication (GO:0046599)2.79838144
97regulation of neurotransmitter secretion (GO:0046928)2.79729422
98protein K6-linked ubiquitination (GO:0085020)2.79176430
99axoneme assembly (GO:0035082)2.79157961
100regulation of respiratory gaseous exchange (GO:0043576)2.79032178
101lactate metabolic process (GO:0006089)2.78703225
102nucleotide transmembrane transport (GO:1901679)2.78206760
103detection of calcium ion (GO:0005513)2.77896989
104branched-chain amino acid catabolic process (GO:0009083)2.77485906
105DNA synthesis involved in DNA repair (GO:0000731)2.76940974
106striatum development (GO:0021756)2.76891285
107GTP biosynthetic process (GO:0006183)2.76529609
108regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76527424
109negative regulation of microtubule polymerization (GO:0031115)2.75753617
110regulation of postsynaptic membrane potential (GO:0060078)2.74073697
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73881032
112positive regulation of synapse maturation (GO:0090129)2.73670720
113synapse assembly (GO:0007416)2.73367734
114histone exchange (GO:0043486)2.71076078
115negative regulation of dendrite morphogenesis (GO:0050774)2.71021666
116mitochondrial RNA metabolic process (GO:0000959)2.70469274
117microtubule severing (GO:0051013)2.70107226
118piRNA metabolic process (GO:0034587)2.69914706
119DNA catabolic process, exonucleolytic (GO:0000738)2.69211584
120nonmotile primary cilium assembly (GO:0035058)2.68930371
121regulation of synapse assembly (GO:0051963)2.68153593
122positive regulation of neurotransmitter secretion (GO:0001956)2.67926482
123positive regulation of neurotransmitter transport (GO:0051590)2.67335690
124exploration behavior (GO:0035640)2.66859393
125dopamine transport (GO:0015872)2.66629539
126membrane hyperpolarization (GO:0060081)2.64375530
127cullin deneddylation (GO:0010388)2.62313740
128meiotic cell cycle process (GO:1903046)2.61855727
129regulation of glutamate secretion (GO:0014048)2.61788696
130male meiosis (GO:0007140)2.61575254
131neurotransmitter transport (GO:0006836)2.61508368
132response to nitrosative stress (GO:0051409)2.61373060
133regulation of synapse maturation (GO:0090128)2.61273602
134meiosis I (GO:0007127)2.61266770
135regulation of neurotransmitter transport (GO:0051588)2.60777641
136sperm-egg recognition (GO:0035036)2.60667374
137aldehyde catabolic process (GO:0046185)2.60486978
138motile cilium assembly (GO:0044458)2.59489793
139establishment of integrated proviral latency (GO:0075713)2.59454009
140negative regulation of dendrite development (GO:2000171)2.58944194
141GMP metabolic process (GO:0046037)2.58867885
142recombinational repair (GO:0000725)2.58546448
143positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.58346915
144transmission of nerve impulse (GO:0019226)2.58288807
145attachment of spindle microtubules to kinetochore (GO:0008608)2.57137772
146pseudouridine synthesis (GO:0001522)2.56811899
147photoreceptor cell maintenance (GO:0045494)2.55866204
148double-strand break repair via homologous recombination (GO:0000724)2.54314951
149female mating behavior (GO:0060180)2.53421255
150mitotic sister chromatid cohesion (GO:0007064)2.52585411
151cytochrome complex assembly (GO:0017004)2.52515018
152L-methionine salvage (GO:0071267)2.52479269
153L-methionine biosynthetic process (GO:0071265)2.52479269
154amino acid salvage (GO:0043102)2.52479269
155rRNA methylation (GO:0031167)2.52343047
156detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52205399
157chaperone-mediated protein complex assembly (GO:0051131)2.51797321
158ribonucleoprotein complex disassembly (GO:0032988)2.51138699
159protein complex biogenesis (GO:0070271)2.50434279
160mitochondrial respiratory chain complex assembly (GO:0033108)2.49876707
161meiotic nuclear division (GO:0007126)2.47268962
162replication fork processing (GO:0031297)2.46994316
163daunorubicin metabolic process (GO:0044597)2.45209248
164polyketide metabolic process (GO:0030638)2.45209248
165doxorubicin metabolic process (GO:0044598)2.45209248
166peptidyl-histidine modification (GO:0018202)2.44849251
167mismatch repair (GO:0006298)2.43602039
168negative regulation of DNA-dependent DNA replication (GO:2000104)2.40932033
169regulation of helicase activity (GO:0051095)2.40516803
170ribosome assembly (GO:0042255)2.39859423
171synaptonemal complex assembly (GO:0007130)2.39263813
172regulation of DNA endoreduplication (GO:0032875)2.39219269
173platelet dense granule organization (GO:0060155)2.39139432
174double-strand break repair via nonhomologous end joining (GO:0006303)2.38983570
175non-recombinational repair (GO:0000726)2.38983570
176transcription from mitochondrial promoter (GO:0006390)2.38911105
177mitochondrial respiratory chain complex I assembly (GO:0032981)2.38862680
178NADH dehydrogenase complex assembly (GO:0010257)2.38862680
179mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.38862680
180telomere maintenance via semi-conservative replication (GO:0032201)2.36189913
181meiotic cell cycle (GO:0051321)2.35790987
182tRNA metabolic process (GO:0006399)2.35381888
183tRNA processing (GO:0008033)2.35128884
184purine nucleobase biosynthetic process (GO:0009113)2.34948328
185establishment of protein localization to mitochondrial membrane (GO:0090151)2.33996137
186spliceosomal snRNP assembly (GO:0000387)2.33582516
187positive regulation of mitochondrial fission (GO:0090141)2.32205992
188L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.32198463
189aminoglycoside antibiotic metabolic process (GO:0030647)2.31922145
190regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31842435
191regulation of mitotic spindle checkpoint (GO:1903504)2.31842435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.28193163
2EZH2_22144423_ChIP-Seq_EOC_Human6.08649112
3GBX2_23144817_ChIP-Seq_PC3_Human4.06484296
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80038188
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.56728515
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.42898901
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.12466585
8TAF15_26573619_Chip-Seq_HEK293_Human3.09562810
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.09172465
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.08818691
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67542449
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59534689
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49313013
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45822487
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37414354
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.36711317
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36200627
18E2F7_22180533_ChIP-Seq_HELA_Human2.31355100
19REST_21632747_ChIP-Seq_MESCs_Mouse2.22136588
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17386583
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16135785
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14568971
23* VDR_23849224_ChIP-Seq_CD4+_Human2.13768304
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10669917
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05883573
26ELK1_19687146_ChIP-ChIP_HELA_Human2.05497249
27P300_19829295_ChIP-Seq_ESCs_Human2.03576718
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00346259
29* FUS_26573619_Chip-Seq_HEK293_Human1.98357755
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.98014734
31RNF2_27304074_Chip-Seq_NSC_Mouse1.97246705
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.96794739
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95574874
34* REST_18959480_ChIP-ChIP_MESCs_Mouse1.88331549
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.86000122
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85704627
37ZNF274_21170338_ChIP-Seq_K562_Hela1.85362081
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84158260
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83859819
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82042886
41FOXP3_21729870_ChIP-Seq_TREG_Human1.79421089
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78846158
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.77460268
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77043998
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.76190315
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75955811
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.75884487
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73771294
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67575919
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67147981
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66846177
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.65410835
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65180764
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64270654
55MYC_18940864_ChIP-ChIP_HL60_Human1.60817595
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59457967
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59047937
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55325112
59DCP1A_22483619_ChIP-Seq_HELA_Human1.55231291
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.54763915
61GATA1_22025678_ChIP-Seq_K562_Human1.54605408
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53962815
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49412809
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48199410
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.46588961
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45982041
67* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45820461
68* NANOG_18555785_Chip-Seq_ESCs_Mouse1.43540877
69VDR_22108803_ChIP-Seq_LS180_Human1.43162820
70EWS_26573619_Chip-Seq_HEK293_Human1.42309428
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.41854050
72IGF1R_20145208_ChIP-Seq_DFB_Human1.41676004
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41055986
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41055986
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40804853
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.40442894
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40034401
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39299064
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39299064
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38893604
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38853833
82* NOTCH1_21737748_ChIP-Seq_TLL_Human1.38594206
83DROSHA_22980978_ChIP-Seq_HELA_Human1.36674590
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35186148
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34505699
86IRF1_19129219_ChIP-ChIP_H3396_Human1.34026018
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.32776019
88TP53_22573176_ChIP-Seq_HFKS_Human1.32078207
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31248563
90* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30963634
91* P53_22387025_ChIP-Seq_ESCs_Mouse1.30784353
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28884839
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28115731
94STAT3_23295773_ChIP-Seq_U87_Human1.27870962
95* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27271431
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.27044203
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24807828
98* TTF2_22483619_ChIP-Seq_HELA_Human1.24395931
99* CMYC_18555785_Chip-Seq_ESCs_Mouse1.24391232
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23563828
101GABP_19822575_ChIP-Seq_HepG2_Human1.23134675
102ER_23166858_ChIP-Seq_MCF-7_Human1.22875890
103AR_25329375_ChIP-Seq_VCAP_Human1.21815682
104* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21727307
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20343782
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19119787
107* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18338485
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18184519
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18161635
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17903735
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.17802410
112TCF4_23295773_ChIP-Seq_U87_Human1.17493195
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.17444977
114* STAT3_18555785_Chip-Seq_ESCs_Mouse1.16957613
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16631474
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16407887
117* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16013828
118SOX9_26525672_Chip-Seq_HEART_Mouse1.14637431
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.14357809
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13936332
121HTT_18923047_ChIP-ChIP_STHdh_Human1.13909870
122KDM2B_26808549_Chip-Seq_REH_Human1.13521913
123HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13326844
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12539569
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12509227
126CBP_20019798_ChIP-Seq_JUKART_Human1.12509227
127* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12076354
128* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11943017
129THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11565634
130MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10868788
131NANOG_19829295_ChIP-Seq_ESCs_Human1.10283189
132SOX2_19829295_ChIP-Seq_ESCs_Human1.10283189
133* P300_18555785_Chip-Seq_ESCs_Mouse1.09932934
134MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09808305
135KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07401992
136* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07332627
137JUN_21703547_ChIP-Seq_K562_Human1.06608454
138FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06124900
139SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05791862
140* RUNX2_22187159_ChIP-Seq_PCA_Human1.05736718
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05453567
142AR_20517297_ChIP-Seq_VCAP_Human1.04820617
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04266199
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03797781
145* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03047625
146ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02710292
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02600924
148FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02521489
149FOXA1_25329375_ChIP-Seq_VCAP_Human1.02521489
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02064483
151* SOX2_18555785_Chip-Seq_ESCs_Mouse1.01952857
152* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01765680
153RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01299411
154CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01082761
155NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99421778
156ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98273834
157NMYC_18555785_Chip-Seq_ESCs_Mouse0.98209168
158KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98122185
159BCAT_22108803_ChIP-Seq_LS180_Human0.97924759
160EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97012491
161AR_21909140_ChIP-Seq_LNCAP_Human0.94579171
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.91966451
163* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91578920
164YY1_21170310_ChIP-Seq_MESCs_Mouse0.88139686
165SOX2_16153702_ChIP-ChIP_HESCs_Human0.88023933
166AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87839499
167NCOR_22424771_ChIP-Seq_293T_Human0.85315098

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.90958296
2MP0004859_abnormal_synaptic_plasticity3.49950689
3MP0005423_abnormal_somatic_nervous3.25815360
4MP0003635_abnormal_synaptic_transmissio3.05007349
5MP0001529_abnormal_vocalization3.01857188
6MP0001984_abnormal_olfaction2.97481786
7MP0004270_analgesia2.94041930
8MP0001968_abnormal_touch/_nociception2.92132676
9MP0008058_abnormal_DNA_repair2.76005800
10MP0009745_abnormal_behavioral_response2.67263089
11MP0003718_maternal_effect2.65238182
12MP0002063_abnormal_learning/memory/cond2.58320618
13MP0002736_abnormal_nociception_after2.56928859
14MP0009046_muscle_twitch2.48291688
15MP0002572_abnormal_emotion/affect_behav2.47779457
16MP0002064_seizures2.46768541
17MP0005646_abnormal_pituitary_gland2.38951429
18MP0002734_abnormal_mechanical_nocicepti2.36301169
19MP0010094_abnormal_chromosome_stability2.36229596
20MP0004147_increased_porphyrin_level2.29057111
21MP0002735_abnormal_chemical_nociception2.28639841
22MP0006276_abnormal_autonomic_nervous2.27944254
23MP0000778_abnormal_nervous_system2.27198370
24MP0003693_abnormal_embryo_hatching2.23390100
25MP0005410_abnormal_fertilization2.22745778
26MP0002272_abnormal_nervous_system2.22157412
27MP0002234_abnormal_pharynx_morphology2.19499987
28MP0002653_abnormal_ependyma_morphology2.16177881
29MP0002139_abnormal_hepatobiliary_system2.12590079
30MP0001188_hyperpigmentation2.12181275
31MP0001486_abnormal_startle_reflex2.08865055
32MP0001986_abnormal_taste_sensitivity2.02615743
33MP0008877_abnormal_DNA_methylation2.02008920
34MP0002067_abnormal_sensory_capabilities1.96485105
35MP0008875_abnormal_xenobiotic_pharmacok1.95712506
36MP0002184_abnormal_innervation1.90724599
37MP0006292_abnormal_olfactory_placode1.88342414
38MP0003195_calcinosis1.84729862
39MP0010386_abnormal_urinary_bladder1.73427976
40MP0001905_abnormal_dopamine_level1.72247623
41MP0002557_abnormal_social/conspecific_i1.70976454
42MP0002822_catalepsy1.69059354
43MP0001970_abnormal_pain_threshold1.64370105
44MP0003136_yellow_coat_color1.63638190
45MP0004924_abnormal_behavior1.60619267
46MP0005386_behavior/neurological_phenoty1.60619267
47MP0002733_abnormal_thermal_nociception1.60077991
48MP0003787_abnormal_imprinting1.55902589
49MP0009780_abnormal_chondrocyte_physiolo1.53153541
50MP0003567_abnormal_fetal_cardiomyocyte1.52952512
51MP0000372_irregular_coat_pigmentation1.51942531
52MP0005085_abnormal_gallbladder_physiolo1.49974732
53MP0004742_abnormal_vestibular_system1.49781731
54MP0003186_abnormal_redox_activity1.49571708
55MP0003183_abnormal_peptide_metabolism1.47530982
56MP0005499_abnormal_olfactory_system1.46690448
57MP0005394_taste/olfaction_phenotype1.46690448
58MP0005551_abnormal_eye_electrophysiolog1.46131328
59MP0000631_abnormal_neuroendocrine_gland1.45441317
60MP0001501_abnormal_sleep_pattern1.43167436
61MP0006035_abnormal_mitochondrial_morpho1.40421310
62MP0001440_abnormal_grooming_behavior1.40265560
63MP0001764_abnormal_homeostasis1.39808003
64MP0003698_abnormal_male_reproductive1.38594156
65MP0004811_abnormal_neuron_physiology1.37877925
66MP0004142_abnormal_muscle_tone1.37424074
67MP0002882_abnormal_neuron_morphology1.37146291
68MP0008057_abnormal_DNA_replication1.36893310
69MP0006036_abnormal_mitochondrial_physio1.36549790
70MP0000955_abnormal_spinal_cord1.33542741
71MP0006072_abnormal_retinal_apoptosis1.32490647
72MP0002938_white_spotting1.30466610
73MP0005365_abnormal_bile_salt1.28627641
74MP0003111_abnormal_nucleus_morphology1.25129646
75MP0001293_anophthalmia1.24268479
76MP0002909_abnormal_adrenal_gland1.21700253
77MP0004957_abnormal_blastocyst_morpholog1.21099654
78MP0003077_abnormal_cell_cycle1.20930817
79MP0005645_abnormal_hypothalamus_physiol1.19037867
80MP0002066_abnormal_motor_capabilities/c1.17740201
81MP0005084_abnormal_gallbladder_morpholo1.17540360
82MP0001485_abnormal_pinna_reflex1.17343361
83MP0000013_abnormal_adipose_tissue1.17277490
84MP0003122_maternal_imprinting1.14841293
85MP0002152_abnormal_brain_morphology1.13505856
86MP0008789_abnormal_olfactory_epithelium1.13158053
87MP0002876_abnormal_thyroid_physiology1.12928073
88MP0002138_abnormal_hepatobiliary_system1.11886267
89MP0002752_abnormal_somatic_nervous1.10924003
90MP0003879_abnormal_hair_cell1.09310797
91MP0004043_abnormal_pH_regulation1.08642589
92MP0001502_abnormal_circadian_rhythm1.06428390
93MP0002751_abnormal_autonomic_nervous1.05115460
94MP0001929_abnormal_gametogenesis1.04289708
95MP0008569_lethality_at_weaning1.03975392
96MP0003123_paternal_imprinting1.02622427
97MP0001963_abnormal_hearing_physiology1.01436584
98MP0003786_premature_aging1.00616360
99MP0000358_abnormal_cell_content/0.99042260
100MP0002233_abnormal_nose_morphology0.98588319
101MP0002229_neurodegeneration0.96255548
102MP0005253_abnormal_eye_physiology0.94683023
103MP0002837_dystrophic_cardiac_calcinosis0.91146242
104MP0005636_abnormal_mineral_homeostasis0.91145635
105MP0005379_endocrine/exocrine_gland_phen0.89880205
106MP0001664_abnormal_digestion0.88800332
107MP0000026_abnormal_inner_ear0.88698142
108MP0003252_abnormal_bile_duct0.88369544
109MP0000647_abnormal_sebaceous_gland0.88149625
110MP0009697_abnormal_copulation0.86551668
111MP0005075_abnormal_melanosome_morpholog0.84793036
112MP0004145_abnormal_muscle_electrophysio0.84059630
113MP0000427_abnormal_hair_cycle0.83422029
114MP0005395_other_phenotype0.82400019
115MP0002210_abnormal_sex_determination0.82077845
116MP0004858_abnormal_nervous_system0.81362197
117MP0002161_abnormal_fertility/fecundity0.81277392
118MP0008932_abnormal_embryonic_tissue0.80521832
119MP0008995_early_reproductive_senescence0.79896995
120MP0001324_abnormal_eye_pigmentation0.79644058
121MP0000516_abnormal_urinary_system0.79453577
122MP0005367_renal/urinary_system_phenotyp0.79453577
123MP0008007_abnormal_cellular_replicative0.79187165
124MP0003861_abnormal_nervous_system0.79073471
125MP0008775_abnormal_heart_ventricle0.78156286
126MP0005174_abnormal_tail_pigmentation0.78117884
127MP0000383_abnormal_hair_follicle0.77701531
128MP0004885_abnormal_endolymph0.77054741
129MP0002069_abnormal_eating/drinking_beha0.76948518
130MP0005187_abnormal_penis_morphology0.76245957
131MP0002102_abnormal_ear_morphology0.75945789
132MP0005389_reproductive_system_phenotype0.75695165
133MP0002160_abnormal_reproductive_system0.75085532
134MP0000751_myopathy0.74001213
135MP0003634_abnormal_glial_cell0.72697700
136MP0003633_abnormal_nervous_system0.72366839
137MP0003646_muscle_fatigue0.72333337
138MP0004133_heterotaxia0.72102190
139MP0005332_abnormal_amino_acid0.71971989
140MP0010030_abnormal_orbit_morphology0.71893810
141MP0003631_nervous_system_phenotype0.71021605
142MP0000569_abnormal_digit_pigmentation0.70633001
143MP0003121_genomic_imprinting0.70064756
144MP0004085_abnormal_heartbeat0.68495376
145MP0004215_abnormal_myocardial_fiber0.67184082
146MP0008872_abnormal_physiological_respon0.66996582
147MP0003890_abnormal_embryonic-extraembry0.65413025
148MP0002163_abnormal_gland_morphology0.64978221
149MP0000653_abnormal_sex_gland0.64767398
150MP0005195_abnormal_posterior_eye0.63561620
151MP0001145_abnormal_male_reproductive0.62905611
152MP0002638_abnormal_pupillary_reflex0.62260322

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.84913440
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.78697650
3Abnormal ciliary motility (HP:0012262)4.58124212
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.55653261
5Absent/shortened dynein arms (HP:0200106)4.55653261
6Abnormal respiratory motile cilium physiology (HP:0012261)4.45563206
7Hypothermia (HP:0002045)4.08859746
8Medial flaring of the eyebrow (HP:0010747)4.03794982
9Gait imbalance (HP:0002141)3.94603224
10Visual hallucinations (HP:0002367)3.89997728
11Abnormal respiratory motile cilium morphology (HP:0005938)3.79213571
12Abnormal respiratory epithelium morphology (HP:0012253)3.79213571
13Atonic seizures (HP:0010819)3.75489748
14Epileptic encephalopathy (HP:0200134)3.73224648
15Congenital primary aphakia (HP:0007707)3.72712477
16Hyperventilation (HP:0002883)3.54314445
17Nephrogenic diabetes insipidus (HP:0009806)3.47870525
18Myokymia (HP:0002411)3.45013209
19Febrile seizures (HP:0002373)3.35458614
20Rhinitis (HP:0012384)3.32969952
21Reduced antithrombin III activity (HP:0001976)3.29676497
22Abnormal hair whorl (HP:0010721)3.27357472
23Pancreatic fibrosis (HP:0100732)3.25862634
24Focal seizures (HP:0007359)3.21748028
25Limb dystonia (HP:0002451)3.11916626
26Progressive cerebellar ataxia (HP:0002073)3.02463715
27Nephronophthisis (HP:0000090)3.00181187
28Volvulus (HP:0002580)3.00128343
29Genital tract atresia (HP:0001827)2.99531624
30Vaginal atresia (HP:0000148)2.90180525
31Molar tooth sign on MRI (HP:0002419)2.89655095
32Abnormality of midbrain morphology (HP:0002418)2.89655095
33Broad-based gait (HP:0002136)2.83360412
34Absence seizures (HP:0002121)2.81646250
35Poor coordination (HP:0002370)2.77167754
36True hermaphroditism (HP:0010459)2.76905634
37Acute necrotizing encephalopathy (HP:0006965)2.73382747
38Specific learning disability (HP:0001328)2.69623680
39Dialeptic seizures (HP:0011146)2.59473825
40Hepatic necrosis (HP:0002605)2.54081911
41Hyperglycinemia (HP:0002154)2.52560243
42Congenital stationary night blindness (HP:0007642)2.52105795
43Abnormal protein glycosylation (HP:0012346)2.50560927
44Abnormal glycosylation (HP:0012345)2.50560927
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50560927
46Abnormal protein N-linked glycosylation (HP:0012347)2.50560927
47Abnormal mitochondria in muscle tissue (HP:0008316)2.50440947
48Amblyopia (HP:0000646)2.49106073
49Hypoglycemic coma (HP:0001325)2.47601624
50Chronic bronchitis (HP:0004469)2.46116810
51Hyperglycinuria (HP:0003108)2.44416570
52Protruding tongue (HP:0010808)2.40182177
53Median cleft lip (HP:0000161)2.40050268
54Hyperinsulinemic hypoglycemia (HP:0000825)2.39719619
55Pancreatic cysts (HP:0001737)2.39627768
56Hepatocellular necrosis (HP:0001404)2.39201733
57Postaxial hand polydactyly (HP:0001162)2.37642907
58Oligodactyly (hands) (HP:0001180)2.36673365
59Ketoacidosis (HP:0001993)2.36531478
60Generalized tonic-clonic seizures (HP:0002069)2.35539309
61Progressive macrocephaly (HP:0004481)2.34901237
62Central scotoma (HP:0000603)2.33645716
63Abnormality of the renal cortex (HP:0011035)2.31110908
64Inability to walk (HP:0002540)2.30827052
65Cerebral edema (HP:0002181)2.29191988
66Increased hepatocellular lipid droplets (HP:0006565)2.28257115
67Gaze-evoked nystagmus (HP:0000640)2.26836027
68Lipid accumulation in hepatocytes (HP:0006561)2.24097030
69Abnormal biliary tract physiology (HP:0012439)2.23698369
70Bile duct proliferation (HP:0001408)2.23698369
71Thyroid-stimulating hormone excess (HP:0002925)2.23594506
72Postaxial foot polydactyly (HP:0001830)2.22356698
73Abnormality of glycine metabolism (HP:0010895)2.20342048
74Abnormality of serine family amino acid metabolism (HP:0010894)2.20342048
75Abnormal rod and cone electroretinograms (HP:0008323)2.16429989
76Aplasia/Hypoplasia of the lens (HP:0008063)2.16415000
77Renal cortical cysts (HP:0000803)2.15641817
78Excessive salivation (HP:0003781)2.14705232
79Drooling (HP:0002307)2.14705232
80Ankle clonus (HP:0011448)2.13197040
81Acute encephalopathy (HP:0006846)2.12276843
82Chromsome breakage (HP:0040012)2.12266120
83Retinal dysplasia (HP:0007973)2.11870309
84Abnormality of macular pigmentation (HP:0008002)2.08378008
85Methylmalonic acidemia (HP:0002912)2.07336101
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06703447
87Degeneration of the lateral corticospinal tracts (HP:0002314)2.06703447
88Abnormality of the renal medulla (HP:0100957)2.04059162
89Impaired vibration sensation in the lower limbs (HP:0002166)2.03960842
90Proximal tubulopathy (HP:0000114)2.03804015
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.98699625
92Intestinal atresia (HP:0011100)1.98502687
93Chronic hepatic failure (HP:0100626)1.98498346
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.98276459
95Mitochondrial inheritance (HP:0001427)1.97606872
96Increased serum lactate (HP:0002151)1.96882728
97Epileptiform EEG discharges (HP:0011182)1.96526500
98Abnormality of chromosome stability (HP:0003220)1.96461509
99Supernumerary spleens (HP:0009799)1.96082804
100Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95738885
101Hypoplasia of the brainstem (HP:0002365)1.95738885
102Hypoglycemic seizures (HP:0002173)1.95196241
103Progressive inability to walk (HP:0002505)1.94414281
104Colon cancer (HP:0003003)1.94310661
105Meckel diverticulum (HP:0002245)1.94142357
106Lactic acidosis (HP:0003128)1.93944439
107Renal Fanconi syndrome (HP:0001994)1.92817480
108Abnormality of urine glucose concentration (HP:0011016)1.91925411
109Glycosuria (HP:0003076)1.91925411
110Gonadotropin excess (HP:0000837)1.91890806
111Ketosis (HP:0001946)1.91754279
112Agitation (HP:0000713)1.91208045
113Type II lissencephaly (HP:0007260)1.90707739
114Large for gestational age (HP:0001520)1.90329263
115Abnormality of the ileum (HP:0001549)1.89377918
116Anosmia (HP:0000458)1.87482091
117Breast carcinoma (HP:0003002)1.87232914
118Pheochromocytoma (HP:0002666)1.85146034
119Truncal ataxia (HP:0002078)1.84617967
120Abnormality of the preputium (HP:0100587)1.84321273
121Dyskinesia (HP:0100660)1.84025196
122Optic disc pallor (HP:0000543)1.83451076
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83415295
124Severe visual impairment (HP:0001141)1.83051625
125Poor eye contact (HP:0000817)1.82955650
126Aplasia/hypoplasia of the uterus (HP:0008684)1.82583721
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.82558970
128Bradykinesia (HP:0002067)1.82338797
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81523167
130Abnormality of alanine metabolism (HP:0010916)1.81523167
131Hyperalaninemia (HP:0003348)1.81523167
132Poor suck (HP:0002033)1.80739307
133Infertility (HP:0000789)1.80636300
134Metaphyseal dysplasia (HP:0100255)1.80572935
135Abnormality of the labia minora (HP:0012880)1.80433635
136Fibular aplasia (HP:0002990)1.80365102
137Type I transferrin isoform profile (HP:0003642)1.79972689
138Lethargy (HP:0001254)1.79850227
139EEG with generalized epileptiform discharges (HP:0011198)1.78812579
140Broad foot (HP:0001769)1.78590000
141Generalized aminoaciduria (HP:0002909)1.78173852
142Retinitis pigmentosa (HP:0000510)1.77501672
143Anxiety (HP:0000739)1.76096728
144Short tibia (HP:0005736)1.76047024
145Occipital encephalocele (HP:0002085)1.75872552
146Fetal akinesia sequence (HP:0001989)1.75649935
147Absent speech (HP:0001344)1.74474787
148Oligodactyly (HP:0012165)1.74169265
149Lissencephaly (HP:0001339)1.74021215
150Astigmatism (HP:0000483)1.73800814
151Facial hemangioma (HP:0000329)1.73418205
152Esotropia (HP:0000565)1.71983414
153Increased CSF lactate (HP:0002490)1.71825998
154Bronchiectasis (HP:0002110)1.71713830
155Hyperphosphaturia (HP:0003109)1.71421723
156Prominent metopic ridge (HP:0005487)1.70835755
157Decreased testicular size (HP:0008734)1.70311584
158Scotoma (HP:0000575)1.69295188
159Oculomotor apraxia (HP:0000657)1.68701779
160Bifid tongue (HP:0010297)1.68429393
161Multicystic kidney dysplasia (HP:0000003)1.68359400
162Short foot (HP:0001773)1.68079022
163Decreased central vision (HP:0007663)1.67676988
164Akinesia (HP:0002304)1.67609875
165Impaired vibratory sensation (HP:0002495)1.67456311
166Impaired smooth pursuit (HP:0007772)1.66957118
167Preaxial hand polydactyly (HP:0001177)1.66917223
168Sclerocornea (HP:0000647)1.66717407
169Hypsarrhythmia (HP:0002521)1.65724503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.77782052
2MAP4K23.66539775
3NTRK33.55295316
4MAP2K73.19350440
5MAP3K123.16936402
6CCNB13.15396710
7FRK3.15039410
8MARK12.96534590
9TIE12.90217395
10VRK22.83288340
11MAP3K42.75373753
12MST42.63572470
13BUB12.56653095
14BMPR1B2.54081668
15EPHA42.44999936
16MAPK132.39004977
17TNIK2.37909339
18MINK12.36006384
19CDK192.28466636
20NEK12.18613247
21ZAK2.12765027
22GRK12.05444725
23ACVR1B1.99691305
24TTK1.95336212
25DAPK21.94163734
26STK161.91740519
27DAPK11.87250674
28PLK21.86469653
29TAF11.79591948
30PNCK1.78507533
31SIK31.75015127
32NUAK11.71627002
33NTRK21.70196723
34STK38L1.67220605
35WNK31.63511963
36KSR11.55475362
37PDK31.51967166
38PDK41.51967166
39MAP2K41.51947785
40BCR1.49900705
41BCKDK1.45547423
42PLK41.45127905
43ERBB31.43550328
44STK391.38477399
45WNK41.37796877
46EIF2AK31.35374668
47GRK51.31649286
48OXSR11.26299338
49PBK1.23760875
50WEE11.22595438
51SCYL21.19067594
52PTK2B1.18122293
53PASK1.18087331
54TRIM281.17555364
55AKT31.15751906
56MKNK11.15556197
57PLK11.09793045
58EIF2AK11.08715898
59CAMKK21.02628464
60CSNK1G31.02119272
61MAP3K91.01124015
62SGK4941.00942541
63SGK2231.00942541
64CDK51.00288114
65SGK21.00114789
66TSSK60.99164023
67CSNK1G20.97579398
68PRKCG0.96678975
69CAMK2B0.95215381
70FGFR20.93752942
71BMPR20.91973123
72ADRBK20.90281004
73PHKG20.89980370
74PHKG10.89980370
75NME10.89631277
76DYRK20.89319790
77ATR0.89022412
78PLK30.84961460
79CAMK2A0.84426227
80RPS6KA40.84100470
81DYRK1A0.83589922
82ERBB40.81871049
83CDK180.80849844
84ATM0.79635540
85UHMK10.77879326
86VRK10.77056068
87BRAF0.76986215
88PRPF4B0.76832754
89PAK60.76257884
90TGFBR10.73471381
91CDC70.71854832
92PAK30.70431084
93PRKD30.70303176
94CDK140.68699733
95GRK70.68124248
96CDK150.68050186
97RPS6KB10.66330737
98MAP3K60.65517840
99RPS6KA20.63568048
100CDK11A0.61170589
101MUSK0.60259468
102BRD40.60193389
103SIK20.58000736
104MYLK0.57464624
105CHEK20.57173194
106EIF2AK20.55780410
107ADRBK10.54301728
108CAMK2D0.53581192
109TLK10.52907097
110CHEK10.52531146
111ARAF0.51855082
112AURKB0.50677957
113OBSCN0.50152175
114PDK20.50035242
115CDK30.49932316
116FER0.49437086
117CDK70.49195330
118PRKCI0.48956518
119FLT30.48829133
120YES10.48403634
121MAPKAPK50.47818478
122STK40.47406947
123CSNK1A1L0.47387081
124CSNK1G10.47113444
125SRPK10.45434051
126PRKCE0.45139931
127STK30.44983584
128CSNK2A20.44729563
129KSR20.43567493
130CDK80.42799871
131DYRK1B0.42126066
132BRSK20.41036927
133CSNK2A10.39861227
134BRSK10.38991744
135MKNK20.38184274
136MET0.37481865
137PRKACA0.36633318
138NTRK10.36500880
139FES0.36150802
140CAMK10.35252421
141NEK20.34468928
142CAMKK10.34363448
143STK240.34353284
144RPS6KA50.34059422
145PRKDC0.33395837
146CSNK1A10.33287763
147CSNK1D0.32183652
148DAPK30.31475573
149STK110.31459946
150PRKG10.30210797
151SGK10.30015617
152PINK10.29872470
153LMTK20.29464749
154INSRR0.28993818

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.88464847
2Synaptic vesicle cycle_Homo sapiens_hsa047213.46607076
3Olfactory transduction_Homo sapiens_hsa047403.10407434
4Taste transduction_Homo sapiens_hsa047422.71673720
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63171430
6Collecting duct acid secretion_Homo sapiens_hsa049662.61519874
7Amphetamine addiction_Homo sapiens_hsa050312.52551051
8Propanoate metabolism_Homo sapiens_hsa006402.48202209
9GABAergic synapse_Homo sapiens_hsa047272.45886521
10Morphine addiction_Homo sapiens_hsa050322.44018745
11Circadian entrainment_Homo sapiens_hsa047132.41201882
12Oxidative phosphorylation_Homo sapiens_hsa001902.37741915
13Fatty acid elongation_Homo sapiens_hsa000622.27397405
14Selenocompound metabolism_Homo sapiens_hsa004502.22983580
15Dopaminergic synapse_Homo sapiens_hsa047282.21230761
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19045630
17Long-term potentiation_Homo sapiens_hsa047202.18244260
18Glutamatergic synapse_Homo sapiens_hsa047242.11167797
19Insulin secretion_Homo sapiens_hsa049112.08863275
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02175937
21Phototransduction_Homo sapiens_hsa047441.97713772
22Parkinsons disease_Homo sapiens_hsa050121.94930920
23Butanoate metabolism_Homo sapiens_hsa006501.94458047
24Serotonergic synapse_Homo sapiens_hsa047261.88282835
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.84917433
26Vibrio cholerae infection_Homo sapiens_hsa051101.84865128
27DNA replication_Homo sapiens_hsa030301.83574389
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77248890
29Huntingtons disease_Homo sapiens_hsa050161.74010251
30Base excision repair_Homo sapiens_hsa034101.73584333
31Alzheimers disease_Homo sapiens_hsa050101.68442884
32Cocaine addiction_Homo sapiens_hsa050301.64463851
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.59605523
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58182959
35Caffeine metabolism_Homo sapiens_hsa002321.52823813
36Peroxisome_Homo sapiens_hsa041461.50075312
37One carbon pool by folate_Homo sapiens_hsa006701.45591860
38Cardiac muscle contraction_Homo sapiens_hsa042601.45390573
39Cholinergic synapse_Homo sapiens_hsa047251.44962272
40Renin secretion_Homo sapiens_hsa049241.40231379
41RNA transport_Homo sapiens_hsa030131.38696568
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37781786
43Long-term depression_Homo sapiens_hsa047301.36879493
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36232418
45Protein export_Homo sapiens_hsa030601.35276495
46Calcium signaling pathway_Homo sapiens_hsa040201.32680007
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31335888
48Tryptophan metabolism_Homo sapiens_hsa003801.30741944
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30661190
50Salivary secretion_Homo sapiens_hsa049701.30401278
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29833988
52Oocyte meiosis_Homo sapiens_hsa041141.20947367
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20528163
54beta-Alanine metabolism_Homo sapiens_hsa004101.17368680
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15698284
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14487726
57Fatty acid degradation_Homo sapiens_hsa000711.13513099
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12509918
59Pyrimidine metabolism_Homo sapiens_hsa002401.12133127
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10862106
61Oxytocin signaling pathway_Homo sapiens_hsa049211.10669664
62Carbon metabolism_Homo sapiens_hsa012001.09610663
63Gastric acid secretion_Homo sapiens_hsa049711.09472916
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08160563
65Arginine and proline metabolism_Homo sapiens_hsa003301.07246147
66Alcoholism_Homo sapiens_hsa050341.06947080
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06793143
68Non-homologous end-joining_Homo sapiens_hsa034501.06710918
69Fatty acid metabolism_Homo sapiens_hsa012121.06612773
70Folate biosynthesis_Homo sapiens_hsa007901.05201146
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04559426
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01773888
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99513788
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.96745403
75Ribosome_Homo sapiens_hsa030100.96709538
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96386394
77Retinol metabolism_Homo sapiens_hsa008300.95978354
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95610706
79Spliceosome_Homo sapiens_hsa030400.94477991
80Axon guidance_Homo sapiens_hsa043600.91819765
81Gap junction_Homo sapiens_hsa045400.91362270
82Cell cycle_Homo sapiens_hsa041100.89427243
83Chemical carcinogenesis_Homo sapiens_hsa052040.88176271
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87693399
85Metabolic pathways_Homo sapiens_hsa011000.87319097
86Fanconi anemia pathway_Homo sapiens_hsa034600.86296831
87Circadian rhythm_Homo sapiens_hsa047100.85601199
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85290445
89Melanogenesis_Homo sapiens_hsa049160.83636800
90Purine metabolism_Homo sapiens_hsa002300.82797143
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78971166
92cAMP signaling pathway_Homo sapiens_hsa040240.77282801
93mRNA surveillance pathway_Homo sapiens_hsa030150.76497455
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75279069
95Glucagon signaling pathway_Homo sapiens_hsa049220.74089315
96Basal transcription factors_Homo sapiens_hsa030220.73951554
97Proteasome_Homo sapiens_hsa030500.73903431
98Homologous recombination_Homo sapiens_hsa034400.73603668
99Tyrosine metabolism_Homo sapiens_hsa003500.73242915
100Glutathione metabolism_Homo sapiens_hsa004800.72615210
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71286238
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70611067
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.70489123
104Steroid biosynthesis_Homo sapiens_hsa001000.69411039
105Biosynthesis of amino acids_Homo sapiens_hsa012300.67747874
106Pyruvate metabolism_Homo sapiens_hsa006200.67223903
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.67063794
108GnRH signaling pathway_Homo sapiens_hsa049120.66061789
109Linoleic acid metabolism_Homo sapiens_hsa005910.66009225
110Nitrogen metabolism_Homo sapiens_hsa009100.65709420
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62796663
112Estrogen signaling pathway_Homo sapiens_hsa049150.61777357
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61061703
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60747065
115Arginine biosynthesis_Homo sapiens_hsa002200.60456479
116RNA polymerase_Homo sapiens_hsa030200.59715885
117Sulfur relay system_Homo sapiens_hsa041220.58786631
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58348226
119ErbB signaling pathway_Homo sapiens_hsa040120.56360151
120N-Glycan biosynthesis_Homo sapiens_hsa005100.56146341
121ABC transporters_Homo sapiens_hsa020100.55690152
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55304408
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54332474
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50903967
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49052699
126RNA degradation_Homo sapiens_hsa030180.48584666
127Mismatch repair_Homo sapiens_hsa034300.48356675
128Sulfur metabolism_Homo sapiens_hsa009200.47349873
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45862899
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.44965753
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44290503
132Pentose phosphate pathway_Homo sapiens_hsa000300.44231780
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43214975
134Vitamin B6 metabolism_Homo sapiens_hsa007500.42736452
135Thyroid hormone synthesis_Homo sapiens_hsa049180.42290693
136Phagosome_Homo sapiens_hsa041450.41231813
137Dorso-ventral axis formation_Homo sapiens_hsa043200.40991429
138Phenylalanine metabolism_Homo sapiens_hsa003600.40369066
139Wnt signaling pathway_Homo sapiens_hsa043100.40275030
140Hedgehog signaling pathway_Homo sapiens_hsa043400.37884040
141p53 signaling pathway_Homo sapiens_hsa041150.37632287
142Rheumatoid arthritis_Homo sapiens_hsa053230.36027959
143Regulation of autophagy_Homo sapiens_hsa041400.35945770
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35931303
145Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35515980
146Nucleotide excision repair_Homo sapiens_hsa034200.35161505
147Ether lipid metabolism_Homo sapiens_hsa005650.34578981
148Lysine degradation_Homo sapiens_hsa003100.34538950
149Arachidonic acid metabolism_Homo sapiens_hsa005900.33973004
150Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33780163
151Type I diabetes mellitus_Homo sapiens_hsa049400.33748703
152MAPK signaling pathway_Homo sapiens_hsa040100.33621777
153Glioma_Homo sapiens_hsa052140.32311160
154Ras signaling pathway_Homo sapiens_hsa040140.31728551
155Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31616508
156Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31399196

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