THNSL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.31909739
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.31909739
3L-phenylalanine metabolic process (GO:0006558)7.12526159
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.12526159
5aromatic amino acid family catabolic process (GO:0009074)6.74001258
6glyoxylate metabolic process (GO:0046487)6.35641635
7indole-containing compound catabolic process (GO:0042436)6.20538846
8indolalkylamine catabolic process (GO:0046218)6.20538846
9tryptophan catabolic process (GO:0006569)6.20538846
10cysteine metabolic process (GO:0006534)6.13942702
11lysine metabolic process (GO:0006553)6.05670719
12lysine catabolic process (GO:0006554)6.05670719
13tryptophan metabolic process (GO:0006568)5.87312763
14kynurenine metabolic process (GO:0070189)5.73412403
15drug transmembrane transport (GO:0006855)5.60091404
16urate metabolic process (GO:0046415)5.54751579
17bile acid biosynthetic process (GO:0006699)5.35611422
18epoxygenase P450 pathway (GO:0019373)5.28363245
19sulfur amino acid catabolic process (GO:0000098)5.23470765
20homocysteine metabolic process (GO:0050667)5.22506352
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.19976337
22drug catabolic process (GO:0042737)5.09665008
23* serine family amino acid catabolic process (GO:0009071)5.02147506
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.97106323
25aromatic amino acid family metabolic process (GO:0009072)4.94464820
26amino-acid betaine metabolic process (GO:0006577)4.93350347
27alpha-linolenic acid metabolic process (GO:0036109)4.79881631
28urea metabolic process (GO:0019627)4.76751549
29urea cycle (GO:0000050)4.76751549
30drug transport (GO:0015893)4.71312983
31* alpha-amino acid catabolic process (GO:1901606)4.65989207
32cellular ketone body metabolic process (GO:0046950)4.60116178
33exogenous drug catabolic process (GO:0042738)4.57482214
34cellular modified amino acid catabolic process (GO:0042219)4.57383569
35omega-hydroxylase P450 pathway (GO:0097267)4.51240447
36bile acid metabolic process (GO:0008206)4.48318467
37nitrogen cycle metabolic process (GO:0071941)4.43256438
38tyrosine metabolic process (GO:0006570)4.42900549
39glutamate metabolic process (GO:0006536)4.42744700
40indolalkylamine metabolic process (GO:0006586)4.42407517
41* serine family amino acid metabolic process (GO:0009069)4.41664900
42* cellular amino acid catabolic process (GO:0009063)4.41501135
43high-density lipoprotein particle remodeling (GO:0034375)4.40093057
44ethanol metabolic process (GO:0006067)4.36224369
45aspartate family amino acid catabolic process (GO:0009068)4.31111513
46protein carboxylation (GO:0018214)4.30548441
47peptidyl-glutamic acid carboxylation (GO:0017187)4.30548441
48negative regulation of fibrinolysis (GO:0051918)4.26205152
49cellular biogenic amine catabolic process (GO:0042402)4.24798182
50amine catabolic process (GO:0009310)4.24798182
51* short-chain fatty acid metabolic process (GO:0046459)4.24390144
52benzene-containing compound metabolic process (GO:0042537)4.22128824
53serine family amino acid biosynthetic process (GO:0009070)4.15153908
54complement activation, alternative pathway (GO:0006957)4.14014831
55cellular glucuronidation (GO:0052695)4.13005787
56regulation of triglyceride catabolic process (GO:0010896)4.08688286
57acetyl-CoA metabolic process (GO:0006084)4.06215224
58regulation of fibrinolysis (GO:0051917)4.04336556
592-oxoglutarate metabolic process (GO:0006103)4.04198877
60regulation of protein activation cascade (GO:2000257)4.02118234
61glycine metabolic process (GO:0006544)4.01783463
62regulation of cholesterol esterification (GO:0010872)4.01143588
63fatty acid beta-oxidation (GO:0006635)4.01116349
64negative regulation of sterol transport (GO:0032372)3.99741979
65negative regulation of cholesterol transport (GO:0032375)3.99741979
66coenzyme catabolic process (GO:0009109)3.99526552
67valine metabolic process (GO:0006573)3.99213176
68aldehyde catabolic process (GO:0046185)3.98400009
69ketone body metabolic process (GO:1902224)3.97437528
70* carboxylic acid catabolic process (GO:0046395)3.95454431
71* organic acid catabolic process (GO:0016054)3.95454431
72response to mercury ion (GO:0046689)3.94947112
73fatty acid oxidation (GO:0019395)3.92046629
74carnitine metabolic process (GO:0009437)3.89856320
75ethanol oxidation (GO:0006069)3.89091891
76triglyceride homeostasis (GO:0070328)3.87915720
77acylglycerol homeostasis (GO:0055090)3.87915720
78reverse cholesterol transport (GO:0043691)3.87782299
79lipid oxidation (GO:0034440)3.85029119
80glucuronate metabolic process (GO:0019585)3.84844339
81uronic acid metabolic process (GO:0006063)3.84844339
82phenylpropanoid metabolic process (GO:0009698)3.83194234
83protein-lipid complex remodeling (GO:0034368)3.79386668
84macromolecular complex remodeling (GO:0034367)3.79386668
85plasma lipoprotein particle remodeling (GO:0034369)3.79386668
86branched-chain amino acid metabolic process (GO:0009081)3.77510999
87monocarboxylic acid catabolic process (GO:0072329)3.77288685
88dicarboxylic acid biosynthetic process (GO:0043650)3.76777803
89regulation of complement activation (GO:0030449)3.76705405
90primary alcohol catabolic process (GO:0034310)3.71578983
91fatty acid catabolic process (GO:0009062)3.71449131
92bile acid and bile salt transport (GO:0015721)3.70818788
93organic cation transport (GO:0015695)3.70320490
94branched-chain amino acid catabolic process (GO:0009083)3.69984160
95phospholipid efflux (GO:0033700)3.67833084
96oxidative demethylation (GO:0070989)3.65613006
97drug metabolic process (GO:0017144)3.64332098
98arginine metabolic process (GO:0006525)3.60234633
99flavonoid metabolic process (GO:0009812)3.54261300
100regulation of cholesterol homeostasis (GO:2000188)3.53960199
101response to nitrosative stress (GO:0051409)3.53403598
102plasma lipoprotein particle clearance (GO:0034381)3.46681741
103phosphate ion transport (GO:0006817)3.42278210
104imidazole-containing compound metabolic process (GO:0052803)3.41564546
105phospholipid homeostasis (GO:0055091)3.37907411
106* small molecule catabolic process (GO:0044282)3.36792420
107negative regulation of protein activation cascade (GO:2000258)3.18514891
108fibrinolysis (GO:0042730)3.13336103
109negative regulation of complement activation (GO:0045916)3.08929035
110quaternary ammonium group transport (GO:0015697)3.03079191
111macroautophagy (GO:0016236)2.94479720
112alkaloid metabolic process (GO:0009820)2.93352319
113axonemal dynein complex assembly (GO:0070286)2.90913392
114S-adenosylmethionine metabolic process (GO:0046500)2.85271619
115peroxisome fission (GO:0016559)2.81773948
116creatine metabolic process (GO:0006600)2.77432764
117blood coagulation, intrinsic pathway (GO:0007597)2.75374888
118primary alcohol metabolic process (GO:0034308)2.74904048
119carnitine transport (GO:0015879)2.74833281
120amino-acid betaine transport (GO:0015838)2.74833281
121xenobiotic metabolic process (GO:0006805)2.68577074
122carnitine transmembrane transport (GO:1902603)2.66256421
123negative regulation of humoral immune response (GO:0002921)2.65141091
124negative regulation of lipase activity (GO:0060192)2.64338098
125xenobiotic catabolic process (GO:0042178)2.60512640
126fatty acid transmembrane transport (GO:1902001)2.57135421
127arginine catabolic process (GO:0006527)2.56021624
128cilium or flagellum-dependent cell motility (GO:0001539)2.53069154
129heme transport (GO:0015886)2.51768758
130regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49167136
131carnitine shuttle (GO:0006853)2.48617372
132short-term memory (GO:0007614)2.47504371
133biotin metabolic process (GO:0006768)2.46983076
134quinone biosynthetic process (GO:1901663)2.45800732
135protein activation cascade (GO:0072376)2.43262055
136regulation of plasminogen activation (GO:0010755)2.42893723
137fat-soluble vitamin biosynthetic process (GO:0042362)2.37852914
138complement activation (GO:0006956)2.37799439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.95051271
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.79562931
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.11167597
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.09410660
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.17414489
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.65646257
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.35594561
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66772422
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.53443146
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.01910640
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.64349057
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43873598
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.40913160
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08763577
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0212328
16DROSHA_22980978_ChIP-Seq_HELA_Human1.89191182
17CLOCK_20551151_ChIP-Seq_293T_Human1.83893150
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78477454
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58964095
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.58186998
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.58038377
22HNF4A_19822575_ChIP-Seq_HepG2_Human1.49045709
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48445131
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44019337
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41448190
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39833677
27EZH2_22144423_ChIP-Seq_EOC_Human1.38486457
28CTCF_27219007_Chip-Seq_Bcells_Human1.38030819
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35056546
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.34419487
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28161218
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27890311
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26377644
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25850953
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25362444
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24619828
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23485105
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22850435
39VDR_22108803_ChIP-Seq_LS180_Human1.20972771
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20327050
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20215794
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19355731
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18060462
44AHR_22903824_ChIP-Seq_MCF-7_Human1.16291661
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16139372
46GATA4_25053715_ChIP-Seq_YYC3_Human1.12035003
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11379984
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.10926480
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.10765765
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.09382240
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09377992
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09377992
53GBX2_23144817_ChIP-Seq_PC3_Human1.08971665
54HTT_18923047_ChIP-ChIP_STHdh_Human1.08610988
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06811474
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.05684274
57GATA1_22025678_ChIP-Seq_K562_Human1.05289243
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02551163
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99932611
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99511462
61IRF8_22096565_ChIP-ChIP_GC-B_Human0.97463053
62CBX2_27304074_Chip-Seq_ESCs_Mouse0.97457399
63RUNX1_27514584_Chip-Seq_MCF-7_Human0.95594445
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95396347
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94058672
66RNF2_27304074_Chip-Seq_ESCs_Mouse0.92741806
67P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91697094
68EP300_21415370_ChIP-Seq_HL-1_Mouse0.90856646
69ARNT_22903824_ChIP-Seq_MCF-7_Human0.89814391
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89688135
71SMC4_20622854_ChIP-Seq_HELA_Human0.88536028
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88442716
73TP63_22573176_ChIP-Seq_HFKS_Human0.87741758
74EZH2_27304074_Chip-Seq_ESCs_Mouse0.87694035
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87453988
76GATA3_24758297_ChIP-Seq_MCF-7_Human0.86286781
77ZNF263_19887448_ChIP-Seq_K562_Human0.86123532
78NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86013578
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84374737
80TRIM28_21343339_ChIP-Seq_HEK293_Human0.83671752
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83590204
82SA1_27219007_Chip-Seq_Bcells_Human0.81997769
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81001072
84FOXO3_23340844_ChIP-Seq_DLD1_Human0.80737755
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79075197
86JARID2_20064375_ChIP-Seq_MESCs_Mouse0.78638975
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78076196
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78076196
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77727180
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77087822
91* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76947521
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76628258
93OCT4_20526341_ChIP-Seq_ESCs_Human0.76463833
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76348453
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76322074
96EGR1_19032775_ChIP-ChIP_M12_Human0.76028672
97* FOXH1_21741376_ChIP-Seq_ESCs_Human0.75650425
98ERA_21632823_ChIP-Seq_H3396_Human0.75332595
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75093772
100CJUN_26792858_Chip-Seq_BT549_Human0.74189355
101ETV2_25802403_ChIP-Seq_MESCs_Mouse0.74135749
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74053075
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72325135
104LXR_22292898_ChIP-Seq_THP-1_Human0.71441828
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70561391
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68135029
107SOX2_20726797_ChIP-Seq_SW620_Human0.67278156
108AR_20517297_ChIP-Seq_VCAP_Human0.66351670
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66023808
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65285612
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.64775081
112GATA6_25053715_ChIP-Seq_YYC3_Human0.64400584
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.62945580
114RARA_24833708_ChIP-Seq_LIVER_Mouse0.62383519
115CEBPB_22108803_ChIP-Seq_LS180_Human0.61378471
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60761937
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60075979
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.59874353
119MYC_19915707_ChIP-ChIP_AK7_Human0.59829271
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59776553
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.59012259
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58145217
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55447596
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.55057127
125* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54617622
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.53135645
127BCAT_22108803_ChIP-Seq_LS180_Human0.52400332
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.52278788
129PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51879491
130TAF2_19829295_ChIP-Seq_ESCs_Human0.51766413
131STAT1_17558387_ChIP-Seq_HELA_Human0.51475076
132RACK7_27058665_Chip-Seq_MCF-7_Human0.50927053
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50632477
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.50424422
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.49694293
136CDX2_22108803_ChIP-Seq_LS180_Human0.49496326
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49400938
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.49163679
139CBP_21632823_ChIP-Seq_H3396_Human0.48635964
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48391754
141* GATA2_19941826_ChIP-Seq_K562_Human0.47871448
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.47551535
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.47551535
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.46939454
145GATA1_19941826_ChIP-Seq_K562_Human0.45949153
146P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.45770314
147FOXH1_21741376_ChIP-Seq_EPCs_Human0.45480529
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.45191300
149P53_21459846_ChIP-Seq_SAOS-2_Human0.45101853
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44678809
151GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.44597404
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.43550075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.16050510
2MP0002139_abnormal_hepatobiliary_system7.78556674
3MP0005085_abnormal_gallbladder_physiolo5.67602856
4MP0005365_abnormal_bile_salt5.57887055
5MP0008875_abnormal_xenobiotic_pharmacok4.78320037
6MP0003252_abnormal_bile_duct3.71028026
7MP0005332_abnormal_amino_acid3.66962945
8MP0003806_abnormal_nucleotide_metabolis3.65285289
9MP0003195_calcinosis3.44540523
10MP0004019_abnormal_vitamin_homeostasis3.22900026
11MP0010329_abnormal_lipoprotein_level3.01655655
12MP0002138_abnormal_hepatobiliary_system2.61446416
13MP0001666_abnormal_nutrient_absorption2.53234890
14MP0009840_abnormal_foam_cell2.49756726
15MP0005083_abnormal_biliary_tract2.44144458
16MP0000751_myopathy2.23905511
17MP0003191_abnormal_cellular_cholesterol2.21097621
18MP0009643_abnormal_urine_homeostasis2.20717472
19MP0004043_abnormal_pH_regulation2.09132784
20MP0004145_abnormal_muscle_electrophysio2.07332438
21MP0002118_abnormal_lipid_homeostasis1.91775968
22MP0009780_abnormal_chondrocyte_physiolo1.85780801
23MP0005319_abnormal_enzyme/_coenzyme1.84366204
24MP0000609_abnormal_liver_physiology1.83297291
25MP0010030_abnormal_orbit_morphology1.80843195
26MP0000566_synostosis1.77700412
27MP0001764_abnormal_homeostasis1.73396874
28MP0005636_abnormal_mineral_homeostasis1.71945024
29MP0005584_abnormal_enzyme/coenzyme_acti1.66774105
30MP0003186_abnormal_redox_activity1.65940752
31MP0002249_abnormal_larynx_morphology1.58592231
32MP0003646_muscle_fatigue1.58446899
33MP0003868_abnormal_feces_composition1.52212661
34MP0003879_abnormal_hair_cell1.51206721
35MP0000749_muscle_degeneration1.45255257
36MP0001756_abnormal_urination1.44875061
37MP0004036_abnormal_muscle_relaxation1.40907120
38MP0005451_abnormal_body_composition1.39975831
39MP0001765_abnormal_ion_homeostasis1.31959058
40MP0005503_abnormal_tendon_morphology1.31548662
41MP0002136_abnormal_kidney_physiology1.26771626
42MP0002108_abnormal_muscle_morphology1.25100653
43MP0004858_abnormal_nervous_system1.23441475
44MP0005084_abnormal_gallbladder_morpholo1.23121437
45MP0000747_muscle_weakness1.16892756
46MP0002876_abnormal_thyroid_physiology1.15544822
47MP0002638_abnormal_pupillary_reflex1.14142737
48MP0002909_abnormal_adrenal_gland1.07644003
49MP0005670_abnormal_white_adipose1.06642867
50MP0005330_cardiomyopathy1.04878190
51MP0009697_abnormal_copulation1.03956943
52MP0000598_abnormal_liver_morphology1.03328734
53MP0006036_abnormal_mitochondrial_physio1.03171830
54MP0009764_decreased_sensitivity_to1.02805633
55MP0004084_abnormal_cardiac_muscle1.01853647
56MP0003011_delayed_dark_adaptation0.99835093
57MP0000462_abnormal_digestive_system0.96720095
58MP0002269_muscular_atrophy0.95278887
59MP0003705_abnormal_hypodermis_morpholog0.94779295
60MP0005551_abnormal_eye_electrophysiolog0.94405362
61MP0000383_abnormal_hair_follicle0.93501186
62MP0004133_heterotaxia0.92070971
63MP0005248_abnormal_Harderian_gland0.91427862
64MP0005647_abnormal_sex_gland0.91327722
65MP0009642_abnormal_blood_homeostasis0.91319852
66MP0005275_abnormal_skin_tensile0.88357219
67MP0005408_hypopigmentation0.88054526
68MP0010386_abnormal_urinary_bladder0.86644238
69MP0005369_muscle_phenotype0.86598559
70MP0005535_abnormal_body_temperature0.86591213
71MP0001502_abnormal_circadian_rhythm0.85205072
72MP0004087_abnormal_muscle_fiber0.85191344
73MP0005220_abnormal_exocrine_pancreas0.84089327
74MP0005620_abnormal_muscle_contractility0.83877361
75MP0008469_abnormal_protein_level0.81676690
76MP0003656_abnormal_erythrocyte_physiolo0.80257584
77MP0000678_abnormal_parathyroid_gland0.79187302
78MP0005058_abnormal_lysosome_morphology0.78238850
79MP0002106_abnormal_muscle_physiology0.77893770
80MP0002132_abnormal_respiratory_system0.77202283
81MP0002078_abnormal_glucose_homeostasis0.77090503
82MP0000604_amyloidosis0.77033127
83MP0004215_abnormal_myocardial_fiber0.76580767
84MP0009763_increased_sensitivity_to0.75746862
85MP0010678_abnormal_skin_adnexa0.74466766
86MP0000759_abnormal_skeletal_muscle0.74078851
87MP0006138_congestive_heart_failure0.73743315
88MP0002254_reproductive_system_inflammat0.72834428
89MP0000026_abnormal_inner_ear0.71665114
90MP0005376_homeostasis/metabolism_phenot0.69430193
91MP0000230_abnormal_systemic_arterial0.69092110
92MP0001984_abnormal_olfaction0.68649296
93MP0001661_extended_life_span0.68041013
94MP0004233_abnormal_muscle_weight0.68030012
95MP0000538_abnormal_urinary_bladder0.67999858
96MP0000013_abnormal_adipose_tissue0.67857986
97MP0000762_abnormal_tongue_morphology0.66435288
98MP0002098_abnormal_vibrissa_morphology0.66378823
99MP0009765_abnormal_xenobiotic_induced0.66017203
100MP0002972_abnormal_cardiac_muscle0.65602492
101MP0002928_abnormal_bile_duct0.65450326
102MP0002971_abnormal_brown_adipose0.64917749
103MP0008789_abnormal_olfactory_epithelium0.64915801
104MP0003638_abnormal_response/metabolism_0.64775603
105MP0008775_abnormal_heart_ventricle0.64085230
106MP0001485_abnormal_pinna_reflex0.62675822
107MP0000467_abnormal_esophagus_morphology0.62628373
108MP0005666_abnormal_adipose_tissue0.62167243
109MP0002234_abnormal_pharynx_morphology0.60207153
110MP0004272_abnormal_basement_membrane0.60097413
111MP0002653_abnormal_ependyma_morphology0.59916441
112MP0004130_abnormal_muscle_cell0.59720827
113MP0002295_abnormal_pulmonary_circulatio0.59671868
114MP0002168_other_aberrant_phenotype0.59260832
115MP0000750_abnormal_muscle_regeneration0.58914674
116MP0002127_abnormal_cardiovascular_syste0.58879229
117MP0005334_abnormal_fat_pad0.57251067
118MP0004264_abnormal_extraembryonic_tissu0.57129077
119MP0002796_impaired_skin_barrier0.55919852
120MP0006035_abnormal_mitochondrial_morpho0.55232933
121MP0010368_abnormal_lymphatic_system0.55154497
122MP0005395_other_phenotype0.53855550
123MP0004147_increased_porphyrin_level0.51242161
124MP0005266_abnormal_metabolism0.49459923
125MP0002135_abnormal_kidney_morphology0.49407697
126MP0005377_hearing/vestibular/ear_phenot0.49095986
127MP0003878_abnormal_ear_physiology0.49095986
128MP0003953_abnormal_hormone_level0.47937772
129MP0003329_amyloid_beta_deposits0.45893179
130MP0008961_abnormal_basal_metabolism0.45189800
131MP0004782_abnormal_surfactant_physiolog0.44472446
132MP0003959_abnormal_lean_body0.44385751
133MP0003724_increased_susceptibility_to0.43307063
134MP0010234_abnormal_vibrissa_follicle0.42853020
135MP0005167_abnormal_blood-brain_barrier0.42584563
136MP0003690_abnormal_glial_cell0.42386442
137MP0005448_abnormal_energy_balance0.41931611
138MP0009053_abnormal_anal_canal0.40470941
139MP0002837_dystrophic_cardiac_calcinosis0.40180437
140MP0003300_gastrointestinal_ulcer0.38034124
141MP0001958_emphysema0.36765967
142MP0008872_abnormal_physiological_respon0.34892388
143MP0009672_abnormal_birth_weight0.34376819
144MP0008874_decreased_physiological_sensi0.32548638
145MP0009384_cardiac_valve_regurgitation0.32145852
146MP0005166_decreased_susceptibility_to0.32069463
147MP0003075_altered_response_to0.29735211
148MP0002896_abnormal_bone_mineralization0.29452955
149MP0000639_abnormal_adrenal_gland0.28842432
150MP0009115_abnormal_fat_cell0.27475773
151MP0008873_increased_physiological_sensi0.27076720
152MP0002822_catalepsy0.26760819
153MP0001845_abnormal_inflammatory_respons0.26103074
154MP0005595_abnormal_vascular_smooth0.25874729

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.43632704
2Intrahepatic cholestasis (HP:0001406)5.71147934
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.27280186
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.24321688
5Deep venous thrombosis (HP:0002625)5.20793220
6Xanthomatosis (HP:0000991)5.16007529
7Hyperglycinuria (HP:0003108)5.14761164
8Gout (HP:0001997)4.73585127
9Abnormality of serine family amino acid metabolism (HP:0010894)4.69231583
10Abnormality of glycine metabolism (HP:0010895)4.69231583
11Ketosis (HP:0001946)4.59333017
12Hypobetalipoproteinemia (HP:0003563)4.50724693
13Prolonged partial thromboplastin time (HP:0003645)4.42612035
14Hyperammonemia (HP:0001987)4.42047366
15Hyperglycinemia (HP:0002154)4.41996616
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.20219591
17Hyperlipoproteinemia (HP:0010980)4.01343160
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.96738812
19Ketoacidosis (HP:0001993)3.94739651
20Abnormality of purine metabolism (HP:0004352)3.90987671
21Abnormality of fatty-acid metabolism (HP:0004359)3.86367999
22Proximal tubulopathy (HP:0000114)3.71947440
23Complement deficiency (HP:0004431)3.66861869
24Hypoglycemic coma (HP:0001325)3.66740676
25Abnormality of nucleobase metabolism (HP:0010932)3.65488545
26Joint hemorrhage (HP:0005261)3.53403069
27Alkalosis (HP:0001948)3.48719031
28Hyperuricemia (HP:0002149)3.46509475
29Increased purine levels (HP:0004368)3.46509475
30Muscle fiber inclusion bodies (HP:0100299)3.46456170
31Hypolipoproteinemia (HP:0010981)3.45813838
32Fat malabsorption (HP:0002630)3.45478164
33Delayed CNS myelination (HP:0002188)3.40787491
34Generalized aminoaciduria (HP:0002909)3.37572455
35Nemaline bodies (HP:0003798)3.33819775
36Epidermoid cyst (HP:0200040)3.29055588
37Exercise-induced myalgia (HP:0003738)3.28875013
38Hypokalemic alkalosis (HP:0001949)3.27493268
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.25436226
40Type 1 muscle fiber predominance (HP:0003803)3.22180491
41Abnormality of methionine metabolism (HP:0010901)3.21287185
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.14793092
43Abnormality of pyrimidine metabolism (HP:0004353)3.14490292
44Abnormality of the common coagulation pathway (HP:0010990)3.12025102
45Hyperactive renin-angiotensin system (HP:0000841)3.11812005
46Metabolic acidosis (HP:0001942)3.10491725
47Hypoalphalipoproteinemia (HP:0003233)3.09437631
48Metabolic alkalosis (HP:0200114)3.08005059
49Increased circulating renin level (HP:0000848)3.06441160
50Abnormality of dicarboxylic acid metabolism (HP:0010995)3.06056110
51Dicarboxylic aciduria (HP:0003215)3.06056110
52Vascular calcification (HP:0004934)3.05280122
53Conjugated hyperbilirubinemia (HP:0002908)3.03024066
54Glomerulonephritis (HP:0000099)2.99684207
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.98511473
56Hydroxyprolinuria (HP:0003080)2.98238099
57Abnormality of proline metabolism (HP:0010907)2.98238099
58Abnormality of serum amino acid levels (HP:0003112)2.95163763
59Absent/shortened dynein arms (HP:0200106)2.85439442
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.85439442
61Lethargy (HP:0001254)2.83536340
62Abnormality of urine glucose concentration (HP:0011016)2.82304554
63Glycosuria (HP:0003076)2.82304554
64Hyperbilirubinemia (HP:0002904)2.80714081
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.78979149
66Abnormal urine output (HP:0012590)2.78434756
67Malnutrition (HP:0004395)2.77690519
68Cardiovascular calcification (HP:0011915)2.72821005
69Hepatocellular carcinoma (HP:0001402)2.72080444
70Hypomagnesemia (HP:0002917)2.70981046
71Abnormal respiratory epithelium morphology (HP:0012253)2.69421419
72Abnormal respiratory motile cilium morphology (HP:0005938)2.69421419
73Abnormality of the intrinsic pathway (HP:0010989)2.69275314
74Polyuria (HP:0000103)2.66314083
75Abnormality of chloride homeostasis (HP:0011422)2.66205267
76Asymmetric septal hypertrophy (HP:0001670)2.63287062
77Abnormal ciliary motility (HP:0012262)2.63038745
78Steatorrhea (HP:0002570)2.59695877
79Abnormal respiratory motile cilium physiology (HP:0012261)2.59203157
80Abnormality of renal excretion (HP:0011036)2.58042469
81Abnormality of complement system (HP:0005339)2.56663223
82Hypercholesterolemia (HP:0003124)2.54795800
83Enlarged kidneys (HP:0000105)2.54541942
84Vomiting (HP:0002013)2.54111625
85Irritability (HP:0000737)2.50798164
86Rickets (HP:0002748)2.50502922
87Muscle fiber splitting (HP:0003555)2.48592105
88Myopathic facies (HP:0002058)2.47464882
89Neonatal onset (HP:0003623)2.44072890
90Muscle hypertrophy of the lower extremities (HP:0008968)2.43858268
91Cerebral edema (HP:0002181)2.40113505
92Myoglobinuria (HP:0002913)2.38679379
93Abnormality of the calf musculature (HP:0001430)2.34376467
94Nephritis (HP:0000123)2.31505163
95Spastic diplegia (HP:0001264)2.31282882
96Calf muscle hypertrophy (HP:0008981)2.26974395
97Nephrolithiasis (HP:0000787)2.26161060
98Sensorimotor neuropathy (HP:0007141)2.26096202
99Late onset (HP:0003584)2.25548734
100Abnormality of magnesium homeostasis (HP:0004921)2.25354384
101Abnormal enzyme/coenzyme activity (HP:0012379)2.23221015
102Hyperphosphaturia (HP:0003109)2.22341025
103Hypoglycemic seizures (HP:0002173)2.21050336
104Stridor (HP:0010307)2.20676914
105Pancreatitis (HP:0001733)2.17222972
106Confusion (HP:0001289)2.15764600
107Rhinitis (HP:0012384)2.15557965
108Exercise-induced muscle cramps (HP:0003710)2.15255835
109Renal tubular acidosis (HP:0001947)2.14076438
110Infantile muscular hypotonia (HP:0008947)2.13878213
111Hyperkalemia (HP:0002153)2.13379890
112Distal lower limb muscle weakness (HP:0009053)2.12917889
113Systemic lupus erythematosus (HP:0002725)2.12628179
114Myocardial infarction (HP:0001658)2.09721900
115Abnormal tarsal ossification (HP:0008369)2.09018854
116Distal arthrogryposis (HP:0005684)2.07751762
117Bundle branch block (HP:0011710)2.06154588
118Abnormality of alkaline phosphatase activity (HP:0004379)2.02462519
119Bulbar palsy (HP:0001283)2.00686869
120Ulnar deviation of the wrist (HP:0003049)2.00428138
121Polydipsia (HP:0001959)1.99777152
122Abnormal drinking behavior (HP:0030082)1.99777152
123Tetany (HP:0001281)1.99721956
124Hypophosphatemia (HP:0002148)1.99594342
125Hyporeflexia of lower limbs (HP:0002600)1.99526811
126Skin nodule (HP:0200036)1.99290336
127Heart block (HP:0012722)1.98566773
128Rhabdomyolysis (HP:0003201)1.97787780
129Broad metatarsal (HP:0001783)1.96740027
130Nausea (HP:0002018)1.96703883
131Abnormal urine phosphate concentration (HP:0012599)1.96472666
132Abnormality of renin-angiotensin system (HP:0000847)1.96118885
133Tubulointerstitial nephritis (HP:0001970)1.95981037
134Decreased circulating renin level (HP:0003351)1.95124671
135Renal salt wasting (HP:0000127)1.93896137
136Hyperaldosteronism (HP:0000859)1.93029468
137Hypophosphatemic rickets (HP:0004912)1.92696828
138Cerebral palsy (HP:0100021)1.91647988
139Bell-shaped thorax (HP:0001591)1.90903664
140Stage 5 chronic kidney disease (HP:0003774)1.89860280
141Tubular atrophy (HP:0000092)1.89696880
142Abnormal atrioventricular conduction (HP:0005150)1.82105090
143Chronic bronchitis (HP:0004469)1.81937181
144Abnormality of midbrain morphology (HP:0002418)1.81761663
145Molar tooth sign on MRI (HP:0002419)1.81761663
146Syncope (HP:0001279)1.76991188
147Occipital encephalocele (HP:0002085)1.74488144
148Mucopolysacchariduria (HP:0008155)1.73615468
149Urinary glycosaminoglycan excretion (HP:0003541)1.73615468
150Cystic liver disease (HP:0006706)1.73096363
151Mitral stenosis (HP:0001718)1.72453583
152Nephronophthisis (HP:0000090)1.72172853
153Aplasia of the musculature (HP:0100854)1.69023874
154Sudden death (HP:0001699)1.68861360
155Amelogenesis imperfecta (HP:0000705)1.68364725
156Right ventricular cardiomyopathy (HP:0011663)1.67927809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.85958126
2WNK44.96253460
3WNK34.86049527
4OXSR13.93054253
5OBSCN3.83319440
6FGFR43.40725949
7EPHA23.22177133
8SIK12.97721009
9ERN12.95964676
10PHKG22.84474476
11PHKG12.84474476
12INSRR2.70039080
13MUSK2.67877447
14MAPKAPK32.60227036
15STK38L2.53792217
16MST1R2.13185785
17PRKD32.00897423
18PIK3CG1.82707645
19STK391.78588101
20ERBB41.77155882
21TAOK31.66655879
22MAPK111.55539457
23FLT31.49258868
24PKN21.46834637
25NTRK31.43026577
26PINK11.41508066
27MAP2K41.35621271
28PDK31.34484299
29PDK41.34484299
30TTN1.32591416
31CASK1.31907119
32EPHA41.31577803
33FRK1.29229972
34TRIB31.27981288
35MAP3K31.26604230
36NME11.26174070
37MAP3K71.25412226
38SGK2231.19615568
39SGK4941.19615568
40PRKD21.17359031
41ABL21.15981766
42ACVR1B1.14511115
43PTK61.13029363
44TYK21.08553269
45GRK61.06221971
46EEF2K1.04058220
47MAP3K141.02513080
48PRKAA21.01924459
49LATS11.01737545
50PDK21.01477350
51NEK90.99829622
52BMPR1B0.96405781
53ADRBK20.94283321
54GSK3A0.93840849
55KDR0.92290925
56TIE10.91485317
57RPS6KA20.88723408
58TRPM70.87936406
59STK160.86746799
60NEK10.86335917
61SGK30.84890686
62TGFBR20.83988169
63MAPK150.83205242
64JAK20.81924018
65CDC42BPA0.80269227
66SGK20.78693761
67MAP2K30.77191146
68PRKAA10.76993282
69LMTK20.75288308
70EPHB10.74248832
71PRKCZ0.72686089
72MARK20.70056472
73PRKCE0.69601263
74STK380.68994148
75MET0.68613828
76PTK20.68461188
77PRKACG0.66699783
78MAPK40.65728938
79SMG10.65241603
80PRKCH0.63913698
81LIMK10.63897753
82MAPK120.63592088
83DYRK1B0.63526241
84DAPK20.63433944
85IRAK30.63053251
86MAPKAPK50.62172726
87PRKD10.59970753
88PDPK10.58977899
89ERBB20.58345829
90TBK10.58262054
91CAMK2D0.57509730
92MAP3K110.56701588
93MAP2K20.56320678
94LRRK20.53490874
95RPS6KB20.53051536
96ROCK10.52471410
97MAP2K60.50899600
98CAMK10.50504343
99MYLK0.50087911
100MAP2K10.48798284
101EPHB20.48249430
102RPS6KA60.48227178
103GRK10.47609653
104DMPK0.47517584
105JAK10.47304196
106TESK10.47276641
107TAF10.47194031
108FER0.46965982
109RIPK10.45726735
110MAP3K60.45003867
111TNK20.43149269
112PIK3CA0.43034177
113CHUK0.42906955
114FGFR20.42755838
115WNK10.41790175
116CAMK2A0.41381389
117MAPK130.40087439
118RPS6KC10.40020630
119RPS6KL10.40020630
120PRKG20.39817874
121CAMK2G0.39434062
122PDK10.38439761
123AKT30.37142055
124TGFBR10.37048335
125CSK0.36668149
126IGF1R0.35966480
127MAP3K130.32972817
128FGFR30.32056037
129PRKCQ0.31034695
130PAK30.29831984
131IRAK20.29733875
132MAPK70.28002326
133IRAK10.27524067
134CDK60.26898664
135PRKCA0.26359839
136MAP3K20.26309759
137EPHA30.24848219
138SGK10.24039887
139PRKCG0.22009302
140CAMK1D0.20429291
141PRKACA0.20237165
142PRKCD0.18228526
143CSNK1G10.17792212
144MAP3K100.13868613

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.76204389
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.48419222
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01467516
4Nitrogen metabolism_Homo sapiens_hsa009102.90493265
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.88246620
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82848290
7Tryptophan metabolism_Homo sapiens_hsa003802.75059092
8Butanoate metabolism_Homo sapiens_hsa006502.64926373
9Arginine biosynthesis_Homo sapiens_hsa002202.64082417
10Fatty acid degradation_Homo sapiens_hsa000712.62294731
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.50757369
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46512755
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42749577
14Propanoate metabolism_Homo sapiens_hsa006402.41179651
15Peroxisome_Homo sapiens_hsa041462.30662382
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14833499
17Complement and coagulation cascades_Homo sapiens_hsa046101.99964958
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98346033
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97589225
20beta-Alanine metabolism_Homo sapiens_hsa004101.90253623
21Fatty acid metabolism_Homo sapiens_hsa012121.87093023
22PPAR signaling pathway_Homo sapiens_hsa033201.82727647
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.80332038
24Pyruvate metabolism_Homo sapiens_hsa006201.76253932
25Histidine metabolism_Homo sapiens_hsa003401.76072515
26Chemical carcinogenesis_Homo sapiens_hsa052041.73795257
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71564854
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.66405009
29Sulfur metabolism_Homo sapiens_hsa009201.64795578
30Bile secretion_Homo sapiens_hsa049761.63253918
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61106771
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61030688
33Selenocompound metabolism_Homo sapiens_hsa004501.59085347
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55886189
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.50534129
36Phenylalanine metabolism_Homo sapiens_hsa003601.48580122
37Retinol metabolism_Homo sapiens_hsa008301.48544548
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38285909
39Vitamin digestion and absorption_Homo sapiens_hsa049771.34811697
40Carbon metabolism_Homo sapiens_hsa012001.33951166
41Starch and sucrose metabolism_Homo sapiens_hsa005001.32686656
42Folate biosynthesis_Homo sapiens_hsa007901.31037245
43Caffeine metabolism_Homo sapiens_hsa002321.30508874
44Tyrosine metabolism_Homo sapiens_hsa003501.25478108
45Fatty acid elongation_Homo sapiens_hsa000621.20929415
46Arginine and proline metabolism_Homo sapiens_hsa003301.19599460
47Biosynthesis of amino acids_Homo sapiens_hsa012301.19324856
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.17356076
49Staphylococcus aureus infection_Homo sapiens_hsa051501.14683266
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13245751
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12023928
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.03817143
53Steroid biosynthesis_Homo sapiens_hsa001001.02387733
54Fat digestion and absorption_Homo sapiens_hsa049751.02204873
55Glutathione metabolism_Homo sapiens_hsa004801.01997986
56ABC transporters_Homo sapiens_hsa020101.01244229
57Lysine degradation_Homo sapiens_hsa003100.93945500
58Sulfur relay system_Homo sapiens_hsa041220.89363513
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86654219
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84683052
61Glycerolipid metabolism_Homo sapiens_hsa005610.83469471
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78762940
63Circadian rhythm_Homo sapiens_hsa047100.66565440
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65494616
65Cardiac muscle contraction_Homo sapiens_hsa042600.62225632
66Dilated cardiomyopathy_Homo sapiens_hsa054140.57134909
67Pentose phosphate pathway_Homo sapiens_hsa000300.56860486
68Vitamin B6 metabolism_Homo sapiens_hsa007500.56749044
69One carbon pool by folate_Homo sapiens_hsa006700.54080559
70Metabolic pathways_Homo sapiens_hsa011000.53890401
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51657362
72Fructose and mannose metabolism_Homo sapiens_hsa000510.48069645
73Sphingolipid metabolism_Homo sapiens_hsa006000.43317682
74Insulin secretion_Homo sapiens_hsa049110.37891690
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.37776414
76Ether lipid metabolism_Homo sapiens_hsa005650.34151465
77Galactose metabolism_Homo sapiens_hsa000520.31780329
78Tight junction_Homo sapiens_hsa045300.28340364
79Protein digestion and absorption_Homo sapiens_hsa049740.27249154
80Fatty acid biosynthesis_Homo sapiens_hsa000610.25478175
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25390551
82Serotonergic synapse_Homo sapiens_hsa047260.23913349
83Phototransduction_Homo sapiens_hsa047440.22768885
84Notch signaling pathway_Homo sapiens_hsa043300.22243117
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22163155
86ECM-receptor interaction_Homo sapiens_hsa045120.21209851
87Insulin resistance_Homo sapiens_hsa049310.20922305
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19179167
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.18567014
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18025272
91Mineral absorption_Homo sapiens_hsa049780.17408766
92Renin-angiotensin system_Homo sapiens_hsa046140.16683095
93Cocaine addiction_Homo sapiens_hsa050300.15749374
94Renin secretion_Homo sapiens_hsa049240.15401833
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11744001
96Linoleic acid metabolism_Homo sapiens_hsa005910.11021693
97Other glycan degradation_Homo sapiens_hsa005110.10731574
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10269354
99Prion diseases_Homo sapiens_hsa050200.07811406
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.05689259
101Arachidonic acid metabolism_Homo sapiens_hsa005900.05165742
102Glucagon signaling pathway_Homo sapiens_hsa049220.04935790
103Collecting duct acid secretion_Homo sapiens_hsa049660.03905220
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02976234
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.01034563
106AMPK signaling pathway_Homo sapiens_hsa041520.00625960
107Oxidative phosphorylation_Homo sapiens_hsa001900.00022821
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1788265
109Hepatitis C_Homo sapiens_hsa05160-0.1784831
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1625453
111Insulin signaling pathway_Homo sapiens_hsa04910-0.1507646
112Parkinsons disease_Homo sapiens_hsa05012-0.1205588
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1160233
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.1025953
115Lysosome_Homo sapiens_hsa04142-0.0635969
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0450289
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0414877
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0024887

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