THOC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CENP-A containing nucleosome assembly (GO:0034080)4.44192554
2chromatin remodeling at centromere (GO:0031055)4.30235074
3DNA ligation (GO:0006266)4.27805884
4mitotic metaphase plate congression (GO:0007080)4.08954163
5kinetochore organization (GO:0051383)3.98145479
6sister chromatid segregation (GO:0000819)3.96522496
7mitotic sister chromatid segregation (GO:0000070)3.92833287
8DNA replication initiation (GO:0006270)3.88819235
9histone exchange (GO:0043486)3.87366645
10centriole replication (GO:0007099)3.79875679
11DNA replication-independent nucleosome organization (GO:0034724)3.76571801
12DNA replication-independent nucleosome assembly (GO:0006336)3.76571801
13DNA double-strand break processing (GO:0000729)3.73484575
14non-recombinational repair (GO:0000726)3.73004423
15double-strand break repair via nonhomologous end joining (GO:0006303)3.73004423
16metaphase plate congression (GO:0051310)3.70004379
17somatic hypermutation of immunoglobulin genes (GO:0016446)3.68031500
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.68031500
19telomere maintenance via recombination (GO:0000722)3.67087487
20kinetochore assembly (GO:0051382)3.66501675
21cullin deneddylation (GO:0010388)3.65432796
22regulation of DNA endoreduplication (GO:0032875)3.63253099
23nucleobase biosynthetic process (GO:0046112)3.59873680
24telomere maintenance via semi-conservative replication (GO:0032201)3.58198495
25purine nucleobase biosynthetic process (GO:0009113)3.55279265
26DNA topological change (GO:0006265)3.51469037
27mitotic recombination (GO:0006312)3.50123472
28DNA replication-dependent nucleosome assembly (GO:0006335)3.47779007
29DNA replication-dependent nucleosome organization (GO:0034723)3.47779007
30rRNA modification (GO:0000154)3.44863723
31DNA strand elongation involved in DNA replication (GO:0006271)3.44437164
327-methylguanosine RNA capping (GO:0009452)3.42539541
33RNA capping (GO:0036260)3.42539541
34DNA strand elongation (GO:0022616)3.41685818
35recombinational repair (GO:0000725)3.38776987
36double-strand break repair via homologous recombination (GO:0000724)3.38086562
377-methylguanosine mRNA capping (GO:0006370)3.37936539
38protein deneddylation (GO:0000338)3.37692144
39ribosome biogenesis (GO:0042254)3.36370286
40DNA replication checkpoint (GO:0000076)3.35673803
41histone H2A acetylation (GO:0043968)3.35436320
42telomere maintenance via telomerase (GO:0007004)3.34986194
43postreplication repair (GO:0006301)3.33205900
44RNA-dependent DNA replication (GO:0006278)3.33001839
45establishment of chromosome localization (GO:0051303)3.32385506
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.31717177
47spliceosomal snRNP assembly (GO:0000387)3.30912625
48intra-S DNA damage checkpoint (GO:0031573)3.30086365
49transcription elongation from RNA polymerase I promoter (GO:0006362)3.28711334
50telomere maintenance via telomere lengthening (GO:0010833)3.25770983
51maturation of 5.8S rRNA (GO:0000460)3.25098823
52somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.24832508
53somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.24832508
54isotype switching (GO:0045190)3.24832508
55attachment of spindle microtubules to kinetochore (GO:0008608)3.22859814
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.22477750
57synapsis (GO:0007129)3.21065188
58histone mRNA metabolic process (GO:0008334)3.19803003
59mitotic G2/M transition checkpoint (GO:0044818)3.19615049
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18579095
61rRNA methylation (GO:0031167)3.17516005
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15471760
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14449006
64regulation of helicase activity (GO:0051095)3.13613034
65nuclear pore organization (GO:0006999)3.13426948
66* maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.13183411
67DNA strand renaturation (GO:0000733)3.13161580
68transcription-coupled nucleotide-excision repair (GO:0006283)3.12492882
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12135885
70regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08008674
71proteasome assembly (GO:0043248)3.07806836
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07616298
73meiotic chromosome segregation (GO:0045132)3.06644332
74pore complex assembly (GO:0046931)3.06595538
75resolution of meiotic recombination intermediates (GO:0000712)3.06530205
76somatic recombination of immunoglobulin gene segments (GO:0016447)3.05708991
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05653030
78spindle checkpoint (GO:0031577)3.05520932
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04971887
80ribosome assembly (GO:0042255)3.04337230
81microtubule depolymerization (GO:0007019)3.04270398
82protein localization to kinetochore (GO:0034501)3.04137099
83nuclear pore complex assembly (GO:0051292)3.03765398
84termination of RNA polymerase I transcription (GO:0006363)3.03247225
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.03183554
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03183554
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03183554
88negative regulation of sister chromatid segregation (GO:0033046)3.03183554
89regulation of mitotic sister chromatid separation (GO:0010965)3.02583339
90regulation of mitotic sister chromatid segregation (GO:0033047)3.02583339
91regulation of sister chromatid segregation (GO:0033045)3.02583339
92somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.00709167
93somatic cell DNA recombination (GO:0016444)3.00709167
94mitotic sister chromatid cohesion (GO:0007064)3.00568968
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00456085
96* replication fork processing (GO:0031297)2.99975343
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.99173081
98termination of RNA polymerase III transcription (GO:0006386)2.99173081
99* negative regulation of DNA recombination (GO:0045910)2.98964294
100sister chromatid cohesion (GO:0007062)2.98827209
101DNA unwinding involved in DNA replication (GO:0006268)2.98260541
102rRNA processing (GO:0006364)2.98130056
103pseudouridine synthesis (GO:0001522)2.97667337
104formation of translation preinitiation complex (GO:0001731)2.97562823
105maturation of SSU-rRNA (GO:0030490)2.96107571
106membrane disassembly (GO:0030397)2.95978503
107nuclear envelope disassembly (GO:0051081)2.95978503
108somatic diversification of immunoglobulins (GO:0016445)2.95621725
109positive regulation of chromosome segregation (GO:0051984)2.95222638
110response to X-ray (GO:0010165)2.95168282
111IMP biosynthetic process (GO:0006188)2.94960632
112mitochondrial RNA metabolic process (GO:0000959)2.94685558
113negative regulation of chromosome segregation (GO:0051985)2.94256599
114regulation of nuclear cell cycle DNA replication (GO:0033262)2.94252354
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.93872370
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93872370
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93872370
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93551530
119rRNA metabolic process (GO:0016072)2.91558021
120telomere maintenance (GO:0000723)2.91470417
121regulation of centriole replication (GO:0046599)2.90981414
122mitotic spindle checkpoint (GO:0071174)2.90738116
123single strand break repair (GO:0000012)2.90569046
124DNA catabolic process, exonucleolytic (GO:0000738)2.90043033
125telomere organization (GO:0032200)2.88642261
126spindle assembly checkpoint (GO:0071173)2.88484234
127monoubiquitinated protein deubiquitination (GO:0035520)2.87443104
128mitotic spindle assembly checkpoint (GO:0007094)2.86752654
129mitotic nuclear envelope disassembly (GO:0007077)2.85492341
130regulation of centrosome cycle (GO:0046605)2.84362260
131negative regulation of ligase activity (GO:0051352)2.83914181
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83914181
133regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83713563
134regulation of mitotic spindle checkpoint (GO:1903504)2.83713563
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83108026
136establishment of integrated proviral latency (GO:0075713)2.81644995
137regulation of chromosome segregation (GO:0051983)2.80887623
138deoxyribonucleotide biosynthetic process (GO:0009263)2.79044415
139regulation of double-strand break repair via homologous recombination (GO:0010569)2.78283120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.45203717
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70066702
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.55758636
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52360914
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.25856512
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.16694454
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95267793
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78600936
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65297727
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.64470471
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62721218
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54056019
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.48817091
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44267360
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43816607
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41490638
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39889440
18* VDR_23849224_ChIP-Seq_CD4+_Human2.39857162
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34257473
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33878785
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25946963
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23408542
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21335598
24* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19185701
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18313865
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17855609
27* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13415046
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12909134
29ELK1_19687146_ChIP-ChIP_HELA_Human2.12087541
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05386842
31FOXP3_21729870_ChIP-Seq_TREG_Human2.02828016
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97758632
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96349198
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90745683
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89304533
36XRN2_22483619_ChIP-Seq_HELA_Human1.82742680
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79669533
38DCP1A_22483619_ChIP-Seq_HELA_Human1.78324464
39FUS_26573619_Chip-Seq_HEK293_Human1.72220633
40TTF2_22483619_ChIP-Seq_HELA_Human1.71939181
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68693305
42* E2F1_21310950_ChIP-Seq_MCF-7_Human1.67384110
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66826826
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.66478358
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62576008
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.60884080
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59810888
48GABP_19822575_ChIP-Seq_HepG2_Human1.57936021
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.56463877
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56356751
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52854332
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50372706
53EWS_26573619_Chip-Seq_HEK293_Human1.48085211
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42792103
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.42360116
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40454623
57TAF15_26573619_Chip-Seq_HEK293_Human1.39274918
58AR_21909140_ChIP-Seq_LNCAP_Human1.37432265
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29295274
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29175162
61MYC_18940864_ChIP-ChIP_HL60_Human1.28743906
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27648875
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.27007995
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25640285
65IRF1_19129219_ChIP-ChIP_H3396_Human1.21677990
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17030271
67CIITA_25753668_ChIP-Seq_RAJI_Human1.16945982
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16630893
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16570511
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.15795133
71KDM5A_27292631_Chip-Seq_BREAST_Human1.12425348
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11269478
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.11112263
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09091742
75ER_23166858_ChIP-Seq_MCF-7_Human1.08617912
76* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08499701
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07577991
78VDR_22108803_ChIP-Seq_LS180_Human1.01275069
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00679779
80CBP_20019798_ChIP-Seq_JUKART_Human1.00679779
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99361373
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98974503
83* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97799588
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97502272
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.96813853
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96434963
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95857213
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93477329
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92911717
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92760582
91IGF1R_20145208_ChIP-Seq_DFB_Human0.92508543
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90609879
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90440151
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.90352811
95* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90288101
96GBX2_23144817_ChIP-Seq_PC3_Human0.89864783
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88826526
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88772808
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88635280
100* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87989479
101NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87443256
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86631372
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85526290
104RNF2_27304074_Chip-Seq_NSC_Mouse0.84224405
105SOX2_16153702_ChIP-ChIP_HESCs_Human0.83748730
106CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83076208
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82771309
108KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82718746
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82235648
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82235648
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81742180
112P300_19829295_ChIP-Seq_ESCs_Human0.80775793
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79827091
114STAT3_18555785_Chip-Seq_ESCs_Mouse0.79552051
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79483982
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78990499
117TP53_22573176_ChIP-Seq_HFKS_Human0.78944106
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77931696
119ZNF274_21170338_ChIP-Seq_K562_Hela0.77211271
120* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76904668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.25394840
2MP0010094_abnormal_chromosome_stability4.14233909
3MP0008058_abnormal_DNA_repair3.91025710
4MP0003693_abnormal_embryo_hatching3.54075799
5MP0008877_abnormal_DNA_methylation3.53961514
6MP0003111_abnormal_nucleus_morphology3.28994918
7* MP0004957_abnormal_blastocyst_morpholog3.16072926
8MP0003077_abnormal_cell_cycle2.94311747
9MP0008007_abnormal_cellular_replicative2.58290747
10MP0003880_abnormal_central_pattern2.57132303
11MP0009697_abnormal_copulation2.47491174
12MP0003123_paternal_imprinting2.42871454
13MP0008932_abnormal_embryonic_tissue2.23702852
14MP0003786_premature_aging2.16399287
15MP0006292_abnormal_olfactory_placode2.16211521
16MP0003787_abnormal_imprinting2.11658168
17MP0001188_hyperpigmentation2.08243286
18MP0002396_abnormal_hematopoietic_system2.05650037
19MP0003121_genomic_imprinting1.99240784
20MP0000372_irregular_coat_pigmentation1.93952657
21MP0006072_abnormal_retinal_apoptosis1.71486910
22MP0008789_abnormal_olfactory_epithelium1.70275039
23MP0005646_abnormal_pituitary_gland1.65948623
24MP0000569_abnormal_digit_pigmentation1.58096210
25MP0002210_abnormal_sex_determination1.54416352
26MP0002102_abnormal_ear_morphology1.53706030
27MP0003718_maternal_effect1.51833022
28MP0003567_abnormal_fetal_cardiomyocyte1.45672850
29MP0001929_abnormal_gametogenesis1.42292864
30MP0005499_abnormal_olfactory_system1.39070041
31MP0005394_taste/olfaction_phenotype1.39070041
32MP0001905_abnormal_dopamine_level1.38248485
33MP0009046_muscle_twitch1.33688719
34MP0001529_abnormal_vocalization1.32596385
35MP0006276_abnormal_autonomic_nervous1.30557103
36MP0000015_abnormal_ear_pigmentation1.28981619
37MP0003698_abnormal_male_reproductive1.28388637
38MP0000350_abnormal_cell_proliferation1.28273031
39MP0004147_increased_porphyrin_level1.28131177
40MP0005253_abnormal_eye_physiology1.27022902
41MP0001145_abnormal_male_reproductive1.24768808
42MP0009745_abnormal_behavioral_response1.23464064
43MP0003941_abnormal_skin_development1.22591366
44MP0003890_abnormal_embryonic-extraembry1.19077791
45MP0002234_abnormal_pharynx_morphology1.18301446
46MP0002233_abnormal_nose_morphology1.16865308
47MP0001286_abnormal_eye_development1.15693544
48MP0000653_abnormal_sex_gland1.15437218
49MP0001730_embryonic_growth_arrest1.15324727
50MP0005410_abnormal_fertilization1.14885879
51MP0001986_abnormal_taste_sensitivity1.14845563
52MP0002160_abnormal_reproductive_system1.11726623
53MP0004859_abnormal_synaptic_plasticity1.11665298
54MP0000566_synostosis1.09357286
55MP0003136_yellow_coat_color1.09294582
56MP0003195_calcinosis1.08695159
57MP0005171_absent_coat_pigmentation1.08417486
58MP0002063_abnormal_learning/memory/cond1.07859274
59MP0003315_abnormal_perineum_morphology1.07410494
60MP0005423_abnormal_somatic_nervous1.07156335
61MP0000631_abnormal_neuroendocrine_gland1.06970660
62MP0002132_abnormal_respiratory_system1.05800829
63MP0002088_abnormal_embryonic_growth/wei1.04377374
64MP0005408_hypopigmentation1.02637091
65MP0004197_abnormal_fetal_growth/weight/1.02038612
66MP0002163_abnormal_gland_morphology0.99642499
67* MP0001697_abnormal_embryo_size0.99418030
68MP0002938_white_spotting0.98560125
69MP0010307_abnormal_tumor_latency0.98384853
70MP0005075_abnormal_melanosome_morpholog0.97628062
71MP0002095_abnormal_skin_pigmentation0.97025937
72MP0003635_abnormal_synaptic_transmissio0.95911316
73* MP0000313_abnormal_cell_death0.95714591
74MP0000778_abnormal_nervous_system0.94538186
75MP0002572_abnormal_emotion/affect_behav0.94064406
76MP0002736_abnormal_nociception_after0.93740391
77MP0004808_abnormal_hematopoietic_stem0.91787046
78MP0005389_reproductive_system_phenotype0.91676599
79MP0001119_abnormal_female_reproductive0.90603393
80MP0005391_vision/eye_phenotype0.90362336
81MP0005380_embryogenesis_phenotype0.89488447
82MP0001672_abnormal_embryogenesis/_devel0.89488447
83MP0001968_abnormal_touch/_nociception0.89251045
84MP0000647_abnormal_sebaceous_gland0.88783780
85MP0003938_abnormal_ear_development0.88651590
86MP0003646_muscle_fatigue0.85073057
87MP0004133_heterotaxia0.85017580
88MP0000383_abnormal_hair_follicle0.84807950
89MP0003943_abnormal_hepatobiliary_system0.84190257
90MP0003119_abnormal_digestive_system0.83960130
91MP0002064_seizures0.83816924
92MP0009703_decreased_birth_body0.83434588
93MP0000427_abnormal_hair_cycle0.83089703
94MP0002161_abnormal_fertility/fecundity0.82034681
95MP0008872_abnormal_physiological_respon0.80428754
96MP0008260_abnormal_autophagy0.80426088
97MP0003806_abnormal_nucleotide_metabolis0.79600860
98* MP0002080_prenatal_lethality0.77867883
99MP0002876_abnormal_thyroid_physiology0.77570557
100MP0002653_abnormal_ependyma_morphology0.77417286
101MP0005379_endocrine/exocrine_gland_phen0.77294072
102MP0003122_maternal_imprinting0.77123287
103MP0001963_abnormal_hearing_physiology0.76763910
104MP0003937_abnormal_limbs/digits/tail_de0.76691929
105MP0002751_abnormal_autonomic_nervous0.75849235
106MP0005367_renal/urinary_system_phenotyp0.75831998
107MP0000516_abnormal_urinary_system0.75831998
108MP0005386_behavior/neurological_phenoty0.75763967
109MP0004924_abnormal_behavior0.75763967
110MP0002638_abnormal_pupillary_reflex0.75408111
111MP0003763_abnormal_thymus_physiology0.75367691
112MP0002067_abnormal_sensory_capabilities0.75116649
113MP0003861_abnormal_nervous_system0.74989413
114MP0002282_abnormal_trachea_morphology0.74090274
115MP0003755_abnormal_palate_morphology0.74058740
116MP0001177_atelectasis0.73772034
117MP0005551_abnormal_eye_electrophysiolog0.73743910
118MP0006035_abnormal_mitochondrial_morpho0.72923613
119MP0004742_abnormal_vestibular_system0.72712666
120MP0006036_abnormal_mitochondrial_physio0.72694149
121MP0003186_abnormal_redox_activity0.72651294
122MP0002084_abnormal_developmental_patter0.72441178
123MP0002697_abnormal_eye_size0.72366693
124MP0001293_anophthalmia0.71925983
125MP0004215_abnormal_myocardial_fiber0.71621833
126MP0000049_abnormal_middle_ear0.71535921
127MP0001486_abnormal_startle_reflex0.71371182
128MP0002735_abnormal_chemical_nociception0.71042106
129MP0001324_abnormal_eye_pigmentation0.70974725
130MP0005174_abnormal_tail_pigmentation0.70945650
131* MP0002085_abnormal_embryonic_tissue0.70926592
132MP0005395_other_phenotype0.70823228
133MP0001440_abnormal_grooming_behavior0.70308631
134MP0002009_preneoplasia0.70123406
135MP0004142_abnormal_muscle_tone0.69400130
136MP0002272_abnormal_nervous_system0.69269360
137MP0003984_embryonic_growth_retardation0.68653190
138MP0002557_abnormal_social/conspecific_i0.68409851
139MP0000358_abnormal_cell_content/0.67479506
140MP0008995_early_reproductive_senescence0.67338361
141MP0001919_abnormal_reproductive_system0.66602832
142MP0001485_abnormal_pinna_reflex0.66200695
143MP0005671_abnormal_response_to0.65649985
144MP0002111_abnormal_tail_morphology0.65425616
145MP0009672_abnormal_birth_weight0.63252345

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.23079804
2Colon cancer (HP:0003003)3.56705665
3Chromsome breakage (HP:0040012)3.46708644
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.39493458
5Oral leukoplakia (HP:0002745)3.03195930
6Breast hypoplasia (HP:0003187)2.89350406
7Abnormality of the preputium (HP:0100587)2.87758436
8Pancreatic fibrosis (HP:0100732)2.86839792
9Embryonal renal neoplasm (HP:0011794)2.85869593
10Abnormality of chromosome stability (HP:0003220)2.78107898
11Selective tooth agenesis (HP:0001592)2.78091842
12Nephroblastoma (Wilms tumor) (HP:0002667)2.74332325
13Abnormal lung lobation (HP:0002101)2.72871650
14Abnormal hair whorl (HP:0010721)2.66588253
15Abnormality of the labia minora (HP:0012880)2.64800555
16Supernumerary spleens (HP:0009799)2.61318812
17Aplastic anemia (HP:0001915)2.60361657
18Volvulus (HP:0002580)2.59882503
19Abnormality of the ileum (HP:0001549)2.50082567
20Meckel diverticulum (HP:0002245)2.49057533
21Medial flaring of the eyebrow (HP:0010747)2.47614229
22Patellar aplasia (HP:0006443)2.47344952
23Myelodysplasia (HP:0002863)2.46858412
24Rhabdomyosarcoma (HP:0002859)2.46101710
25Abnormal spermatogenesis (HP:0008669)2.44329831
26Abnormality of the carotid arteries (HP:0005344)2.44243889
27Pancreatic cysts (HP:0001737)2.41383768
28Ectopic kidney (HP:0000086)2.38367843
29Microvesicular hepatic steatosis (HP:0001414)2.36602269
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.32733618
31Ependymoma (HP:0002888)2.29624890
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29039299
33Aplasia/Hypoplasia of the patella (HP:0006498)2.28939685
34True hermaphroditism (HP:0010459)2.28894114
35Abnormality of the anterior horn cell (HP:0006802)2.27229623
36Degeneration of anterior horn cells (HP:0002398)2.27229623
37Premature graying of hair (HP:0002216)2.26454848
383-Methylglutaconic aciduria (HP:0003535)2.25901363
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.24313195
40Type 2 muscle fiber atrophy (HP:0003554)2.22714639
41Small intestinal stenosis (HP:0012848)2.22187133
42Duodenal stenosis (HP:0100867)2.22187133
43Glioma (HP:0009733)2.21171052
44Congenital primary aphakia (HP:0007707)2.20254626
45Chronic hepatic failure (HP:0100626)2.19162730
46Bone marrow hypocellularity (HP:0005528)2.18316763
47Rough bone trabeculation (HP:0100670)2.18071654
48Gait imbalance (HP:0002141)2.17823427
49Impulsivity (HP:0100710)2.15747083
50Cerebral hypomyelination (HP:0006808)2.13214133
51Nephrogenic diabetes insipidus (HP:0009806)2.12656157
52Combined immunodeficiency (HP:0005387)2.11152583
53Abnormality of the columella (HP:0009929)2.09415555
54Increased serum pyruvate (HP:0003542)2.08985532
55Abnormality of glycolysis (HP:0004366)2.08985532
56Focal motor seizures (HP:0011153)2.07292176
57Aplasia/Hypoplasia of the sternum (HP:0006714)2.07242249
58Cortical dysplasia (HP:0002539)2.06486934
59Nephronophthisis (HP:0000090)2.05974245
60Preaxial hand polydactyly (HP:0001177)2.02245742
61Protruding tongue (HP:0010808)2.01725298
62Severe combined immunodeficiency (HP:0004430)1.99987458
63Astrocytoma (HP:0009592)1.98268319
64Abnormality of the astrocytes (HP:0100707)1.98268319
65Acute myeloid leukemia (HP:0004808)1.97643049
66Sloping forehead (HP:0000340)1.96045897
67Agnosia (HP:0010524)1.95759877
68Absent radius (HP:0003974)1.95537633
69Poor coordination (HP:0002370)1.95434978
70Aplasia involving forearm bones (HP:0009822)1.95208047
71Absent forearm bone (HP:0003953)1.95208047
72Acute necrotizing encephalopathy (HP:0006965)1.94140825
73Tongue fasciculations (HP:0001308)1.92525992
74Fair hair (HP:0002286)1.91447694
75Abnormality of methionine metabolism (HP:0010901)1.91267947
76Neoplasm of the colon (HP:0100273)1.90602958
77Medulloblastoma (HP:0002885)1.90107338
78Shoulder girdle muscle weakness (HP:0003547)1.89476724
79Atrophy/Degeneration involving motor neurons (HP:0007373)1.89260948
80Short middle phalanx of the 5th finger (HP:0004220)1.89199674
81Increased nuchal translucency (HP:0010880)1.88725541
82Dynein arm defect of respiratory motile cilia (HP:0012255)1.88641692
83Absent/shortened dynein arms (HP:0200106)1.88641692
84Tubulointerstitial nephritis (HP:0001970)1.88044086
85Median cleft lip (HP:0000161)1.87666368
86Horseshoe kidney (HP:0000085)1.86653887
8711 pairs of ribs (HP:0000878)1.85797218
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.85456910
89Abnormality of DNA repair (HP:0003254)1.85111775
90Muscle fiber atrophy (HP:0100295)1.84864061
91Acute encephalopathy (HP:0006846)1.84371114
92Abnormality of the duodenum (HP:0002246)1.82094122
93Reticulocytopenia (HP:0001896)1.81633411
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81554690
95Abnormality of the renal medulla (HP:0100957)1.80012159
96Abnormality of midbrain morphology (HP:0002418)1.79795837
97Molar tooth sign on MRI (HP:0002419)1.79795837
98Short tibia (HP:0005736)1.79387832
99Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78797621
100Thyroiditis (HP:0100646)1.78303532
101Gastrointestinal atresia (HP:0002589)1.77753497
102Cellular immunodeficiency (HP:0005374)1.77606613
103Dandy-Walker malformation (HP:0001305)1.77119581
104Duplicated collecting system (HP:0000081)1.75661350
105Intestinal atresia (HP:0011100)1.75039907
106Pancytopenia (HP:0001876)1.74968305
107Carpal bone hypoplasia (HP:0001498)1.74694699
108Pancreatic islet-cell hyperplasia (HP:0004510)1.73949964
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.73570206
110Oligodactyly (hands) (HP:0001180)1.72942928
111Amaurosis fugax (HP:0100576)1.72907989
112Neoplasm of the oral cavity (HP:0100649)1.72320498
113Methylmalonic acidemia (HP:0002912)1.71911989
114Astigmatism (HP:0000483)1.71716296
115Type I transferrin isoform profile (HP:0003642)1.71666855
116Increased hepatocellular lipid droplets (HP:0006565)1.71210835
117Renal cortical cysts (HP:0000803)1.69690625
118Bifid tongue (HP:0010297)1.69302795
119Clubbing of toes (HP:0100760)1.68921963
120Capillary hemangiomas (HP:0005306)1.68825033
121Azoospermia (HP:0000027)1.68574882
122Oculomotor apraxia (HP:0000657)1.68053837
123Neoplasm of striated muscle (HP:0009728)1.67481563
124Epileptic encephalopathy (HP:0200134)1.67445260
125Abnormality of cochlea (HP:0000375)1.66751532
126Progressive macrocephaly (HP:0004481)1.65973460
127Facial cleft (HP:0002006)1.65468923
128Genital tract atresia (HP:0001827)1.65305488
129Amyotrophic lateral sclerosis (HP:0007354)1.65191561
130Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63444637
131Abnormality of alanine metabolism (HP:0010916)1.63385924
132Hyperalaninemia (HP:0003348)1.63385924
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63385924
134Abnormal number of erythroid precursors (HP:0012131)1.63373710
135Gonadotropin excess (HP:0000837)1.63187916
136Aganglionic megacolon (HP:0002251)1.63033942
137IgG deficiency (HP:0004315)1.62711484
138Abnormal trabecular bone morphology (HP:0100671)1.62091404
139Biliary tract neoplasm (HP:0100574)1.62023194
140Triphalangeal thumb (HP:0001199)1.61978883
141Postaxial foot polydactyly (HP:0001830)1.60732056
142Squamous cell carcinoma (HP:0002860)1.60727532
143Increased CSF lactate (HP:0002490)1.60607878
144Abnormal respiratory epithelium morphology (HP:0012253)1.59855551
145Abnormal mitochondria in muscle tissue (HP:0008316)1.59755315
146Abnormality of the renal collecting system (HP:0004742)1.58901600
147Cafe-au-lait spot (HP:0000957)1.57751206
148Oligodactyly (HP:0012165)1.56773728
149Abnormality of the renal cortex (HP:0011035)1.56432929
150Neoplasm of the small intestine (HP:0100833)1.55759316
151Cupped ear (HP:0000378)1.55200336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.44738152
2STK163.36827512
3WEE13.20849645
4CASK2.99090800
5MKNK22.97812681
6MKNK12.91323019
7SRPK12.55252873
8EIF2AK12.54037194
9BRSK22.53189786
10TSSK62.50104238
11CDC72.39664836
12MAP2K72.31929993
13PLK42.14038164
14PLK32.10541544
15VRK11.99776370
16TTK1.97699713
17TRIM281.94868511
18CCNB11.77461121
19MST41.75930898
20ACVR1B1.75089604
21CDK81.63031470
22AKT31.62551573
23PLK11.59835157
24MAP4K21.59495057
25EIF2AK31.53890853
26ATR1.50759588
27MAP3K121.46676744
28PLK21.46246065
29BRSK11.39184969
30ZAK1.36165414
31BMPR1B1.36050847
32SIK31.28026863
33MAP3K41.21497935
34NEK21.19587832
35DAPK11.13896194
36PDK41.13738385
37PDK31.13738385
38ERBB31.09589485
39VRK21.08646609
40NEK11.08285066
41CHEK21.07771785
42NTRK31.03021635
43MUSK1.00008602
44TGFBR10.99520237
45BRAF0.97629360
46DYRK30.96555078
47YES10.96156898
48BCR0.96107569
49TAF10.94397916
50AURKB0.94078141
51PRPF4B0.91800673
52TNIK0.91430198
53CDK30.90404061
54CHEK10.89555077
55PNCK0.88896605
56FRK0.86151497
57CSNK1G10.84547815
58STK38L0.82399775
59EIF2AK20.81251415
60STK30.80931826
61NEK60.80298283
62TXK0.79132846
63CDK70.78019615
64ATM0.77275042
65MAPK130.76496935
66TLK10.75390289
67EPHA40.72406979
68BRD40.71969927
69PBK0.70972875
70AURKA0.66730532
71CSNK1A1L0.65895848
72BMPR20.65415845
73CSNK1G30.64552282
74INSRR0.64476984
75MARK30.64367708
76PDK20.63943668
77STK390.63709750
78DYRK20.63456605
79CSNK1G20.63276271
80MAP3K60.62162887
81CSNK2A20.61656280
82CSNK2A10.61495915
83ADRBK20.61018756
84OXSR10.59188515
85KSR10.58757478
86NME20.57813356
87MARK10.57509580
88CDK10.56691384
89NUAK10.56092192
90CDK20.55712198
91PRKCG0.54839558
92NLK0.54563474
93NME10.53076711
94PASK0.50976615
95FGFR10.49630016
96PAK30.49446957
97GRK10.48022320
98STK40.47882745
99MAP2K40.47511870
100FLT30.47363383
101CDK190.46398011
102MINK10.46182112
103SCYL20.45992844
104IRAK40.45909736
105PRKDC0.43899666
106WNK30.43341314
107RPS6KB10.42254970
108RPS6KB20.41902192
109RAF10.41340485
110DYRK1A0.37982318
111CLK10.37688179
112SGK20.37105119
113LATS10.36277177
114PINK10.35822904
115DAPK20.33943307
116RIPK40.32603229
117FGFR20.32167191
118CDK180.32125398
119ALK0.32030035
120CDK40.30474307
121RPS6KA50.27929072
122PRKCE0.27761739
123RPS6KA40.26493519
124CSNK1D0.26302771
125CSNK1E0.24835494
126TEC0.24728503
127STK240.24245250
128TAOK20.23677977
129WNK40.23388483
130CSNK1A10.23222121
131PRKACB0.21997137

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.15609283
2DNA replication_Homo sapiens_hsa030303.97544482
3Mismatch repair_Homo sapiens_hsa034303.86345405
4Proteasome_Homo sapiens_hsa030503.70054598
5RNA polymerase_Homo sapiens_hsa030203.45556867
6Homologous recombination_Homo sapiens_hsa034403.29765917
7* Spliceosome_Homo sapiens_hsa030403.05138307
8* RNA transport_Homo sapiens_hsa030132.92601919
9Basal transcription factors_Homo sapiens_hsa030222.86703334
10Nucleotide excision repair_Homo sapiens_hsa034202.83191637
11Fanconi anemia pathway_Homo sapiens_hsa034602.61518104
12Base excision repair_Homo sapiens_hsa034102.56086182
13Cell cycle_Homo sapiens_hsa041102.53089562
14RNA degradation_Homo sapiens_hsa030182.39058739
15Pyrimidine metabolism_Homo sapiens_hsa002402.24524178
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22423178
17Non-homologous end-joining_Homo sapiens_hsa034502.06774092
18mRNA surveillance pathway_Homo sapiens_hsa030151.94498626
19Ribosome_Homo sapiens_hsa030101.91077556
20Propanoate metabolism_Homo sapiens_hsa006401.75601082
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64707429
22Purine metabolism_Homo sapiens_hsa002301.63401862
23Oocyte meiosis_Homo sapiens_hsa041141.50072965
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33144194
25Steroid biosynthesis_Homo sapiens_hsa001001.31205527
26Nicotine addiction_Homo sapiens_hsa050331.30313146
27One carbon pool by folate_Homo sapiens_hsa006701.26620675
28Vitamin B6 metabolism_Homo sapiens_hsa007501.24754697
29Protein export_Homo sapiens_hsa030601.24676463
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22682182
31Huntingtons disease_Homo sapiens_hsa050161.14147037
32Epstein-Barr virus infection_Homo sapiens_hsa051691.13876957
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07825465
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06244591
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05212045
36p53 signaling pathway_Homo sapiens_hsa041151.03217073
37Selenocompound metabolism_Homo sapiens_hsa004500.96208771
38Oxidative phosphorylation_Homo sapiens_hsa001900.95901178
39Butanoate metabolism_Homo sapiens_hsa006500.93096698
40Parkinsons disease_Homo sapiens_hsa050120.92422636
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88715249
42Pyruvate metabolism_Homo sapiens_hsa006200.88309175
43Type I diabetes mellitus_Homo sapiens_hsa049400.80392825
44Collecting duct acid secretion_Homo sapiens_hsa049660.80081223
45Herpes simplex infection_Homo sapiens_hsa051680.74087074
46Glutathione metabolism_Homo sapiens_hsa004800.72305753
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72281256
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71555624
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70490952
50Systemic lupus erythematosus_Homo sapiens_hsa053220.69074476
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.65670714
52Fatty acid elongation_Homo sapiens_hsa000620.63486214
53Synaptic vesicle cycle_Homo sapiens_hsa047210.60669285
54Nitrogen metabolism_Homo sapiens_hsa009100.59655616
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58893580
56Allograft rejection_Homo sapiens_hsa053300.58728013
57Amphetamine addiction_Homo sapiens_hsa050310.58166481
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57839233
59Long-term potentiation_Homo sapiens_hsa047200.57117418
60Alcoholism_Homo sapiens_hsa050340.55952668
61Viral carcinogenesis_Homo sapiens_hsa052030.55106945
62Autoimmune thyroid disease_Homo sapiens_hsa053200.51020585
63Lysine degradation_Homo sapiens_hsa003100.50701340
64Dopaminergic synapse_Homo sapiens_hsa047280.48309726
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47993326
66Peroxisome_Homo sapiens_hsa041460.47168343
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47061141
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46963096
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45812448
70Pentose phosphate pathway_Homo sapiens_hsa000300.44751427
71Morphine addiction_Homo sapiens_hsa050320.44732769
72Alzheimers disease_Homo sapiens_hsa050100.43906423
73Caffeine metabolism_Homo sapiens_hsa002320.43541757
74HTLV-I infection_Homo sapiens_hsa051660.43416472
75Serotonergic synapse_Homo sapiens_hsa047260.42325562
76Biosynthesis of amino acids_Homo sapiens_hsa012300.41423381
77Hedgehog signaling pathway_Homo sapiens_hsa043400.40952187
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40675348
79Antigen processing and presentation_Homo sapiens_hsa046120.39793920
80Folate biosynthesis_Homo sapiens_hsa007900.38789168
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38675969
82Rheumatoid arthritis_Homo sapiens_hsa053230.38114130
83Taste transduction_Homo sapiens_hsa047420.37641685
84Fatty acid metabolism_Homo sapiens_hsa012120.37202951
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37160932
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36429799
87Basal cell carcinoma_Homo sapiens_hsa052170.36119905
88Regulation of autophagy_Homo sapiens_hsa041400.35496513
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35400868
90Olfactory transduction_Homo sapiens_hsa047400.35100997
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35097707
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35033093
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34796965
94Circadian entrainment_Homo sapiens_hsa047130.34795552
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34506045
96Primary immunodeficiency_Homo sapiens_hsa053400.34490705
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34083262
98Asthma_Homo sapiens_hsa053100.32663496
99Glutamatergic synapse_Homo sapiens_hsa047240.32459455
100Legionellosis_Homo sapiens_hsa051340.32415227
101Shigellosis_Homo sapiens_hsa051310.32410979
102Phototransduction_Homo sapiens_hsa047440.32179778
103Vibrio cholerae infection_Homo sapiens_hsa051100.32039404
104Graft-versus-host disease_Homo sapiens_hsa053320.31926502
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31096346
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30945247
107Calcium signaling pathway_Homo sapiens_hsa040200.29153064
108Linoleic acid metabolism_Homo sapiens_hsa005910.29149062
109Long-term depression_Homo sapiens_hsa047300.28848782
110Retinol metabolism_Homo sapiens_hsa008300.26942114
111GABAergic synapse_Homo sapiens_hsa047270.26515801
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25827160
113Carbon metabolism_Homo sapiens_hsa012000.24428438
114MicroRNAs in cancer_Homo sapiens_hsa052060.24388745
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23512299
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23271633
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23250512
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23167305
119Fatty acid degradation_Homo sapiens_hsa000710.22980799
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.22834412
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22774390
122Ether lipid metabolism_Homo sapiens_hsa005650.22556683
123TGF-beta signaling pathway_Homo sapiens_hsa043500.22249324
124Hippo signaling pathway_Homo sapiens_hsa043900.21454580
125Tryptophan metabolism_Homo sapiens_hsa003800.20250359
126Measles_Homo sapiens_hsa051620.18632254
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17409596
128Metabolic pathways_Homo sapiens_hsa011000.15861059
129Chemical carcinogenesis_Homo sapiens_hsa052040.15418231
130Vitamin digestion and absorption_Homo sapiens_hsa049770.15203756
131N-Glycan biosynthesis_Homo sapiens_hsa005100.15149846
132Hematopoietic cell lineage_Homo sapiens_hsa046400.14828913
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14772545
134Phagosome_Homo sapiens_hsa041450.14769264
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14521468
136beta-Alanine metabolism_Homo sapiens_hsa004100.14422526
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14277840
138Colorectal cancer_Homo sapiens_hsa052100.14032883
139Hepatitis B_Homo sapiens_hsa051610.13700719
140Wnt signaling pathway_Homo sapiens_hsa043100.12682010
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11671088
142Influenza A_Homo sapiens_hsa051640.11670466
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11455779
144Circadian rhythm_Homo sapiens_hsa047100.10421741
145Arachidonic acid metabolism_Homo sapiens_hsa005900.10092408

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