THOC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.36144839
2regulation of DNA endoreduplication (GO:0032875)4.09281850
3DNA replication checkpoint (GO:0000076)3.95650995
4kinetochore organization (GO:0051383)3.93566023
5mitotic sister chromatid cohesion (GO:0007064)3.88235540
6histone H3-K4 trimethylation (GO:0080182)3.81715274
7synapsis (GO:0007129)3.56908636
8DNA replication-dependent nucleosome assembly (GO:0006335)3.55931436
9DNA replication-dependent nucleosome organization (GO:0034723)3.55931436
10telomere maintenance via semi-conservative replication (GO:0032201)3.55909181
11negative regulation of DNA-dependent DNA replication (GO:2000104)3.53052348
12postreplication repair (GO:0006301)3.46881947
13histone H3-K9 methylation (GO:0051567)3.46791048
14telomere maintenance via recombination (GO:0000722)3.45271388
15mRNA splice site selection (GO:0006376)3.43090920
16meiotic chromosome segregation (GO:0045132)3.42134946
17resolution of meiotic recombination intermediates (GO:0000712)3.41572705
18nucleotide-excision repair, DNA gap filling (GO:0006297)3.41230828
19double-strand break repair via homologous recombination (GO:0000724)3.40633348
20proteasome assembly (GO:0043248)3.40492779
21recombinational repair (GO:0000725)3.39352206
22nuclear pore complex assembly (GO:0051292)3.39008705
23DNA strand elongation involved in DNA replication (GO:0006271)3.38896659
24definitive hemopoiesis (GO:0060216)3.37891580
25peptidyl-lysine trimethylation (GO:0018023)3.31367157
26translesion synthesis (GO:0019985)3.29738318
27histone H2A acetylation (GO:0043968)3.23564592
28DNA strand elongation (GO:0022616)3.21030690
29regulation of centrosome cycle (GO:0046605)3.17918944
30DNA ligation (GO:0006266)3.15045991
31cullin deneddylation (GO:0010388)3.11406444
32DNA topological change (GO:0006265)3.06072619
33mitotic nuclear envelope disassembly (GO:0007077)3.05563824
34non-recombinational repair (GO:0000726)3.05301121
35double-strand break repair via nonhomologous end joining (GO:0006303)3.05301121
36kinetochore assembly (GO:0051382)3.04572424
37negative regulation of DNA recombination (GO:0045910)3.03592236
38CENP-A containing nucleosome assembly (GO:0034080)3.01018812
39mitotic spindle checkpoint (GO:0071174)3.00893957
40nuclear pore organization (GO:0006999)2.99552644
41centriole replication (GO:0007099)2.97970918
42regulation of centrosome duplication (GO:0010824)2.97755453
43regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97632312
44regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97632312
45purine nucleobase biosynthetic process (GO:0009113)2.96007655
46somatic hypermutation of immunoglobulin genes (GO:0016446)2.94998715
47somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94998715
48DNA catabolic process, exonucleolytic (GO:0000738)2.94936488
49replication fork processing (GO:0031297)2.94749148
50attachment of spindle microtubules to kinetochore (GO:0008608)2.92550968
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89358737
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89358737
53negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89358737
54negative regulation of mitotic sister chromatid separation (GO:2000816)2.89358737
55negative regulation of sister chromatid segregation (GO:0033046)2.89358737
56regulation of sister chromatid segregation (GO:0033045)2.88917226
57regulation of mitotic sister chromatid separation (GO:0010965)2.88917226
58regulation of mitotic sister chromatid segregation (GO:0033047)2.88917226
59reciprocal DNA recombination (GO:0035825)2.86634948
60reciprocal meiotic recombination (GO:0007131)2.86634948
61chromatin remodeling at centromere (GO:0031055)2.86188158
62negative regulation of chromosome segregation (GO:0051985)2.85267097
63telomere maintenance via telomere lengthening (GO:0010833)2.84634273
64nucleobase biosynthetic process (GO:0046112)2.84599484
65protein localization to chromosome, centromeric region (GO:0071459)2.82436538
66histone H3-K9 modification (GO:0061647)2.82134384
67centrosome organization (GO:0051297)2.81569515
68DNA-dependent DNA replication (GO:0006261)2.80196715
69double-strand break repair (GO:0006302)2.79939206
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79257698
71pore complex assembly (GO:0046931)2.78238787
72sister chromatid cohesion (GO:0007062)2.76624356
73mitotic spindle assembly checkpoint (GO:0007094)2.76170375
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76016705
75spindle assembly checkpoint (GO:0071173)2.74821257
76mitotic chromosome condensation (GO:0007076)2.73584642
77protein deneddylation (GO:0000338)2.73285024
78DNA replication-independent nucleosome assembly (GO:0006336)2.73103064
79DNA replication-independent nucleosome organization (GO:0034724)2.73103064
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73069180
81membrane disassembly (GO:0030397)2.72478531
82nuclear envelope disassembly (GO:0051081)2.72478531
83regulation of chromosome segregation (GO:0051983)2.72209140
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.72035250
85chromosome segregation (GO:0007059)2.71743858
86metaphase plate congression (GO:0051310)2.70491857
87centriole assembly (GO:0098534)2.69649732
88negative regulation of translation, ncRNA-mediated (GO:0040033)2.68877906
89regulation of translation, ncRNA-mediated (GO:0045974)2.68877906
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68877906
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64335940
92regulation of histone H3-K27 methylation (GO:0061085)2.64248812
93replicative senescence (GO:0090399)2.63586756
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.59862167
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.59862167
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.59862167
97histone H3-K4 methylation (GO:0051568)2.59400109
98histone H3-K36 demethylation (GO:0070544)2.54005916
99kidney morphogenesis (GO:0060993)2.53726869
100positive regulation of histone H3-K4 methylation (GO:0051571)2.52010301
101microtubule anchoring (GO:0034453)2.46953730
102establishment of chromosome localization (GO:0051303)2.45445207
103positive regulation of DNA-dependent DNA replication (GO:2000105)2.44207447
104cytoplasmic mRNA processing body assembly (GO:0033962)2.42460293
105DNA strand renaturation (GO:0000733)2.41367347
106mitotic metaphase plate congression (GO:0007080)2.41353708
107telomere maintenance via telomerase (GO:0007004)2.41192837
108sister chromatid segregation (GO:0000819)2.39446749
109V(D)J recombination (GO:0033151)2.39207689
110regulation of mRNA splicing, via spliceosome (GO:0048024)2.38867131
111microtubule depolymerization (GO:0007019)2.38484468
112histone H2B ubiquitination (GO:0033523)2.37426147
113interkinetic nuclear migration (GO:0022027)2.34843399
114positive regulation of histone methylation (GO:0031062)2.33485436
115neural tube formation (GO:0001841)2.31789482
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.29567576
117regulation of mitotic spindle checkpoint (GO:1903504)2.29567576
118histone exchange (GO:0043486)2.27785567
119response to X-ray (GO:0010165)2.26401306
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26018242
121RNA-dependent DNA replication (GO:0006278)2.25654312
122regulation of histone methylation (GO:0031060)2.22293396
123RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.22196307
124regulation of centriole replication (GO:0046599)2.21534040
125regulation of telomere maintenance (GO:0032204)2.21261965
126histone lysine methylation (GO:0034968)2.20953841
127mismatch repair (GO:0006298)2.19787823
128regulation of helicase activity (GO:0051095)2.19729033
129alternative mRNA splicing, via spliceosome (GO:0000380)2.19722559
130limb bud formation (GO:0060174)2.19452112
131regulation of MHC class II biosynthetic process (GO:0045346)2.18989121
132protein localization to kinetochore (GO:0034501)2.16954524
133peptidyl-lysine methylation (GO:0018022)2.16703761
134regulation of mRNA processing (GO:0050684)2.15360741
135regulation of histone H3-K4 methylation (GO:0051569)2.15129081
136regulation of sister chromatid cohesion (GO:0007063)2.15111527
137mitotic recombination (GO:0006312)2.13939085
138regulation of establishment of cell polarity (GO:2000114)2.13554583
139regulation of chromatin silencing (GO:0031935)2.13013439
140regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.12664518
141ATP-dependent chromatin remodeling (GO:0043044)2.08840573
142* mRNA export from nucleus (GO:0006406)2.08174510
143mesenchymal cell differentiation involved in renal system development (GO:2001012)2.08001140
144mesenchymal cell differentiation involved in kidney development (GO:0072161)2.08001140
145regulation of DNA-dependent DNA replication (GO:0090329)2.07761794
146protein K6-linked ubiquitination (GO:0085020)2.07604422
147mitotic sister chromatid segregation (GO:0000070)2.05941697
148lymphoid progenitor cell differentiation (GO:0002320)2.05647982
149positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.05258403
150regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.05258403
151nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.04348624
152spindle checkpoint (GO:0031577)2.04250735
153establishment of mitotic spindle orientation (GO:0000132)2.04162357
154mitotic G2/M transition checkpoint (GO:0044818)2.04111003
155positive regulation of mRNA metabolic process (GO:1903313)2.03064407
156cell differentiation involved in metanephros development (GO:0072202)2.02869823
157regulation of mRNA metabolic process (GO:1903311)2.02705113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.27885047
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.18825191
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51232981
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16122153
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.83676218
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.79196104
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.74497845
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.73111802
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64442205
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.58040067
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52949547
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.50173704
13FUS_26573619_Chip-Seq_HEK293_Human2.37445887
14ZNF274_21170338_ChIP-Seq_K562_Hela2.28801678
15ELK1_19687146_ChIP-ChIP_HELA_Human2.25161445
16EWS_26573619_Chip-Seq_HEK293_Human2.23392065
17VDR_22108803_ChIP-Seq_LS180_Human2.18281746
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12602277
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.08217970
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07365667
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04678417
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92464015
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.92124712
24AR_21909140_ChIP-Seq_LNCAP_Human1.74501725
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74278247
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.73388759
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68471289
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67144218
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66555332
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64621464
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63952124
32GBX2_23144817_ChIP-Seq_PC3_Human1.62376414
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60715718
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.60544229
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60200799
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59531261
37* E2F1_21310950_ChIP-Seq_MCF-7_Human1.59457977
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57796177
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57384112
40* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53467837
41MYC_18940864_ChIP-ChIP_HL60_Human1.52000130
42TAF15_26573619_Chip-Seq_HEK293_Human1.49553810
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.47905128
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47522012
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44625353
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44175045
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43120553
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42912896
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39205228
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.37299164
51P300_19829295_ChIP-Seq_ESCs_Human1.37084516
52GATA1_22025678_ChIP-Seq_K562_Human1.36820544
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.33816048
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.33678308
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33297477
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.32380758
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27634976
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26580520
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.25312236
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24446937
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.24032368
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23969282
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23541964
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23209944
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22299520
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21779795
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20949556
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20818661
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20590123
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19656128
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.19166888
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.18682643
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.18247193
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17380108
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16960213
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16621869
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.16565198
78ER_23166858_ChIP-Seq_MCF-7_Human1.15641053
79P53_22387025_ChIP-Seq_ESCs_Mouse1.15268115
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15181179
81TP53_16413492_ChIP-PET_HCT116_Human1.15153171
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15082400
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14371799
84P300_18555785_Chip-Seq_ESCs_Mouse1.14228369
85NMYC_18555785_Chip-Seq_ESCs_Mouse1.13640256
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.12621549
87OCT4_18555785_Chip-Seq_ESCs_Mouse1.12164448
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11235660
89CBP_20019798_ChIP-Seq_JUKART_Human1.11235660
90IGF1R_20145208_ChIP-Seq_DFB_Human1.10503006
91* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10289048
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10244639
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10244639
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09617363
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08891065
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08850662
97DCP1A_22483619_ChIP-Seq_HELA_Human1.08276341
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07636744
99TTF2_22483619_ChIP-Seq_HELA_Human1.07074979
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05329090
101IRF1_19129219_ChIP-ChIP_H3396_Human1.04305785
102SMAD4_21799915_ChIP-Seq_A2780_Human1.03781222
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.02925229
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.02236299
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02061008
106SCL_19346495_ChIP-Seq_HPC-7_Human1.01479851
107VDR_23849224_ChIP-Seq_CD4+_Human0.99931246
108RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99486734
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98966936
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98959215
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98752635
112ZFX_18555785_Chip-Seq_ESCs_Mouse0.98405266
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97855242
114RNF2_27304074_Chip-Seq_NSC_Mouse0.97778826
115FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97341554
116STAT3_23295773_ChIP-Seq_U87_Human0.96972289
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96709592
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.94865846
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94775203
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.94599666
121NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94540843
122TCF4_23295773_ChIP-Seq_U87_Human0.94191923
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93174552
124TP53_22573176_ChIP-Seq_HFKS_Human0.92850839
125GABP_19822575_ChIP-Seq_HepG2_Human0.92136060
126RUNX_20019798_ChIP-Seq_JUKART_Human0.90825246
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90799487
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90290460
129AR_25329375_ChIP-Seq_VCAP_Human0.90271534
130KLF4_18555785_Chip-Seq_ESCs_Mouse0.89379621
131NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89149521
132FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88824970
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88193838
134FOXP3_21729870_ChIP-Seq_TREG_Human0.87478647
135HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87273181
136BRD4_25478319_ChIP-Seq_HGPS_Human0.87005084
137CTCF_18555785_Chip-Seq_ESCs_Mouse0.86461678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.50688227
2MP0003787_abnormal_imprinting3.42391708
3MP0000569_abnormal_digit_pigmentation2.74764109
4MP0003136_yellow_coat_color2.64463037
5MP0010094_abnormal_chromosome_stability2.55740770
6MP0001188_hyperpigmentation2.43508989
7MP0008877_abnormal_DNA_methylation2.38152112
8MP0003718_maternal_effect2.37081783
9MP0005409_darkened_coat_color2.30569459
10MP0008058_abnormal_DNA_repair2.27354587
11MP0003121_genomic_imprinting2.26861018
12MP0002009_preneoplasia2.24528239
13MP0008007_abnormal_cellular_replicative2.14505026
14MP0000566_synostosis2.08721162
15MP0002396_abnormal_hematopoietic_system2.08128943
16MP0000383_abnormal_hair_follicle1.95845216
17MP0000015_abnormal_ear_pigmentation1.93396728
18MP0003077_abnormal_cell_cycle1.83224510
19MP0006292_abnormal_olfactory_placode1.79396705
20MP0004147_increased_porphyrin_level1.78951410
21MP0005174_abnormal_tail_pigmentation1.77853059
22MP0003111_abnormal_nucleus_morphology1.71452413
23MP0005171_absent_coat_pigmentation1.67759621
24MP0003941_abnormal_skin_development1.67363806
25MP0003693_abnormal_embryo_hatching1.63246342
26MP0002102_abnormal_ear_morphology1.49238818
27MP0010307_abnormal_tumor_latency1.45696076
28MP0004381_abnormal_hair_follicle1.44618301
29MP0002095_abnormal_skin_pigmentation1.42961521
30MP0003763_abnormal_thymus_physiology1.41973377
31MP0010678_abnormal_skin_adnexa1.41660484
32MP0002938_white_spotting1.41205739
33MP0001835_abnormal_antigen_presentation1.34886541
34MP0002160_abnormal_reproductive_system1.33827035
35MP0003950_abnormal_plasma_membrane1.33051403
36MP0003937_abnormal_limbs/digits/tail_de1.30017228
37MP0001929_abnormal_gametogenesis1.28763126
38MP0003195_calcinosis1.27501161
39MP0002210_abnormal_sex_determination1.26498685
40MP0002277_abnormal_respiratory_mucosa1.25315665
41MP0000372_irregular_coat_pigmentation1.23664110
42MP0000465_gastrointestinal_hemorrhage1.22197974
43MP0003890_abnormal_embryonic-extraembry1.21590073
44MP0004808_abnormal_hematopoietic_stem1.20346631
45MP0005551_abnormal_eye_electrophysiolog1.18741872
46MP0000647_abnormal_sebaceous_gland1.18483815
47MP0005646_abnormal_pituitary_gland1.17311127
48MP0002234_abnormal_pharynx_morphology1.17179553
49MP0002837_dystrophic_cardiac_calcinosis1.16919336
50MP0001697_abnormal_embryo_size1.15082477
51MP0002751_abnormal_autonomic_nervous1.15082123
52MP0000653_abnormal_sex_gland1.14994984
53MP0005075_abnormal_melanosome_morpholog1.12095534
54MP0001529_abnormal_vocalization1.11785496
55MP0002084_abnormal_developmental_patter1.11103667
56MP0006035_abnormal_mitochondrial_morpho1.10659291
57MP0002166_altered_tumor_susceptibility1.09956402
58MP0003786_premature_aging1.08825457
59MP0003755_abnormal_palate_morphology1.08544006
60MP0006072_abnormal_retinal_apoptosis1.07813402
61MP0001145_abnormal_male_reproductive1.07130201
62MP0004957_abnormal_blastocyst_morpholog1.05520012
63MP0003123_paternal_imprinting1.05108892
64MP0009697_abnormal_copulation1.03323183
65MP0005380_embryogenesis_phenotype1.02999950
66MP0001672_abnormal_embryogenesis/_devel1.02999950
67MP0006054_spinal_hemorrhage1.02768768
68MP0002177_abnormal_outer_ear1.01983233
69MP0000703_abnormal_thymus_morphology1.00838138
70MP0002006_tumorigenesis0.99880414
71MP0001186_pigmentation_phenotype0.97912180
72MP0001293_anophthalmia0.97661090
73MP0001879_abnormal_lymphatic_vessel0.97565832
74MP0005187_abnormal_penis_morphology0.96990284
75MP0005671_abnormal_response_to0.96291034
76MP0001986_abnormal_taste_sensitivity0.95109206
77MP0005394_taste/olfaction_phenotype0.94726348
78MP0005499_abnormal_olfactory_system0.94726348
79MP0000432_abnormal_head_morphology0.94583861
80MP0000049_abnormal_middle_ear0.94371759
81MP0000490_abnormal_crypts_of0.94358884
82MP0002398_abnormal_bone_marrow0.94207565
83MP0001286_abnormal_eye_development0.93950016
84MP0003567_abnormal_fetal_cardiomyocyte0.93633619
85MP0002088_abnormal_embryonic_growth/wei0.93160143
86MP0002638_abnormal_pupillary_reflex0.93129499
87MP0001800_abnormal_humoral_immune0.92725251
88MP0003698_abnormal_male_reproductive0.91749313
89MP0008932_abnormal_embryonic_tissue0.91538392
90MP0002163_abnormal_gland_morphology0.91187322
91MP0003984_embryonic_growth_retardation0.90677880
92MP0003935_abnormal_craniofacial_develop0.88826145
93MP0005645_abnormal_hypothalamus_physiol0.88300234
94MP0002098_abnormal_vibrissa_morphology0.88037455
95MP0002085_abnormal_embryonic_tissue0.87810280
96MP0005395_other_phenotype0.87769289
97MP0003943_abnormal_hepatobiliary_system0.87258179
98MP0002452_abnormal_antigen_presenting0.86798567
99MP0003122_maternal_imprinting0.85126614
100MP0001119_abnormal_female_reproductive0.84983485
101MP0010030_abnormal_orbit_morphology0.84763750
102MP0004043_abnormal_pH_regulation0.83550679
103MP0004197_abnormal_fetal_growth/weight/0.83547425
104MP0002075_abnormal_coat/hair_pigmentati0.83375743
105MP0001730_embryonic_growth_arrest0.83253336
106MP0002420_abnormal_adaptive_immunity0.82593137
107MP0002877_abnormal_melanocyte_morpholog0.81636995
108MP0001819_abnormal_immune_cell0.80217442
109MP0001764_abnormal_homeostasis0.79762413
110MP0000350_abnormal_cell_proliferation0.77845248
111MP0004215_abnormal_myocardial_fiber0.77785093
112MP0002736_abnormal_nociception_after0.77404997
113MP0009046_muscle_twitch0.76845966
114MP0002697_abnormal_eye_size0.76284509
115MP0000427_abnormal_hair_cycle0.76160197
116MP0002109_abnormal_limb_morphology0.75976802
117MP0002132_abnormal_respiratory_system0.75963467
118MP0004134_abnormal_chest_morphology0.75407364
119MP0005253_abnormal_eye_physiology0.75003639
120MP0005367_renal/urinary_system_phenotyp0.74983941
121MP0000516_abnormal_urinary_system0.74983941
122MP0000358_abnormal_cell_content/0.74765776
123MP0002233_abnormal_nose_morphology0.74063362
124MP0006036_abnormal_mitochondrial_physio0.73878988
125MP0001919_abnormal_reproductive_system0.73642600
126MP0005379_endocrine/exocrine_gland_phen0.73641002
127MP0005503_abnormal_tendon_morphology0.73310472
128MP0009250_abnormal_appendicular_skeleto0.73233944
129MP0002933_joint_inflammation0.72103111
130MP0003880_abnormal_central_pattern0.71922942
131MP0008995_early_reproductive_senescence0.71553201
132MP0004133_heterotaxia0.71502327
133MP0001853_heart_inflammation0.71355070
134MP0001851_eye_inflammation0.71349864
135MP0009379_abnormal_foot_pigmentation0.71046339
136MP0008789_abnormal_olfactory_epithelium0.70133596
137MP0005391_vision/eye_phenotype0.70071631
138MP0003315_abnormal_perineum_morphology0.69646514
139MP0008872_abnormal_physiological_respon0.69541016
140MP0003938_abnormal_ear_development0.69203686
141MP0005389_reproductive_system_phenotype0.68948141
142MP0008775_abnormal_heart_ventricle0.68748244
143MP0000631_abnormal_neuroendocrine_gland0.68433430
144MP0001324_abnormal_eye_pigmentation0.68393123
145MP0000716_abnormal_immune_system0.68230538
146MP0002723_abnormal_immune_serum0.68199272
147MP0003385_abnormal_body_wall0.67635528
148MP0001790_abnormal_immune_system0.66867001
149MP0005387_immune_system_phenotype0.66867001
150MP0005408_hypopigmentation0.64688176
151MP0002060_abnormal_skin_morphology0.63620807
152MP0005000_abnormal_immune_tolerance0.62600573
153MP0002116_abnormal_craniofacial_bone0.62551169
154MP0003828_pulmonary_edema0.62271753

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.95315028
2Chromsome breakage (HP:0040012)3.53751026
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36754195
4Abnormality of the labia minora (HP:0012880)2.74715783
5Abnormality of the fingertips (HP:0001211)2.74483566
6Renal cortical cysts (HP:0000803)2.57428099
7Lip pit (HP:0100267)2.56724632
8Abnormality of the columella (HP:0009929)2.52752596
9Sloping forehead (HP:0000340)2.45123611
10Absent frontal sinuses (HP:0002688)2.44489018
11Abnormality of the renal collecting system (HP:0004742)2.43017165
12Nephronophthisis (HP:0000090)2.41284037
13Abnormality of incisor morphology (HP:0011063)2.36494740
14Medial flaring of the eyebrow (HP:0010747)2.35732078
15Short middle phalanx of the 5th finger (HP:0004220)2.34988580
16Abnormality of the duodenum (HP:0002246)2.34346990
17Deep philtrum (HP:0002002)2.33472492
18Abnormal hair whorl (HP:0010721)2.31799191
19Abnormality of chromosome stability (HP:0003220)2.31712315
20Duplicated collecting system (HP:0000081)2.28965293
21Abnormality of the nasal septum (HP:0000419)2.28646500
22Ectopic kidney (HP:0000086)2.27486484
23Nephroblastoma (Wilms tumor) (HP:0002667)2.26727190
24Rhabdomyosarcoma (HP:0002859)2.25516489
25Abnormality of the renal cortex (HP:0011035)2.22065637
26Supernumerary spleens (HP:0009799)2.20019088
27Aplasia cutis congenita (HP:0001057)2.19765321
28Embryonal renal neoplasm (HP:0011794)2.19250553
29True hermaphroditism (HP:0010459)2.18716935
30Abnormality of the renal medulla (HP:0100957)2.14488141
31Stomach cancer (HP:0012126)2.14055241
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.11994687
33Cupped ear (HP:0000378)2.11793592
34Abnormality of the carotid arteries (HP:0005344)2.10909093
35Colon cancer (HP:0003003)2.09483148
36Spinal cord lesions (HP:0100561)2.08906353
37Syringomyelia (HP:0003396)2.08906353
38Aplasia/Hypoplasia of the tibia (HP:0005772)2.07455115
39Glioma (HP:0009733)2.07181516
40Intestinal atresia (HP:0011100)2.06297305
41Abnormality of methionine metabolism (HP:0010901)2.04165808
42Congenital primary aphakia (HP:0007707)2.02768285
43Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02103167
44Prostate neoplasm (HP:0100787)1.99576452
45Acute necrotizing encephalopathy (HP:0006965)1.99018275
4611 pairs of ribs (HP:0000878)1.98889178
47Pancreatic fibrosis (HP:0100732)1.96742299
48Abnormality of the incisor (HP:0000676)1.96707636
49Increased nuchal translucency (HP:0010880)1.96171791
50Bifid tongue (HP:0010297)1.93305296
51Myelodysplasia (HP:0002863)1.92907754
52Nephrogenic diabetes insipidus (HP:0009806)1.92672921
53Pancreatic islet-cell hyperplasia (HP:0004510)1.91438828
54Acute encephalopathy (HP:0006846)1.91193003
55Gait imbalance (HP:0002141)1.90892239
56Submucous cleft hard palate (HP:0000176)1.90392112
57Triphalangeal thumb (HP:0001199)1.89603477
58Neoplasm of the adrenal cortex (HP:0100641)1.89577355
59Genital tract atresia (HP:0001827)1.89408291
60Methylmalonic acidemia (HP:0002912)1.89358348
61Absent eyebrow (HP:0002223)1.89006938
62Neoplasm of the tracheobronchial system (HP:0100552)1.88522493
63Molar tooth sign on MRI (HP:0002419)1.88475897
64Abnormality of midbrain morphology (HP:0002418)1.88475897
65Progressive macrocephaly (HP:0004481)1.88373505
66Acute myeloid leukemia (HP:0004808)1.86149809
67Short tibia (HP:0005736)1.86106509
68Abnormality of the preputium (HP:0100587)1.84793469
69Bile duct proliferation (HP:0001408)1.84669511
70Abnormal biliary tract physiology (HP:0012439)1.84669511
71Abnormality of the nasolacrimal system (HP:0000614)1.83890766
72Postaxial foot polydactyly (HP:0001830)1.82817521
73Abnormality of the frontal sinuses (HP:0002687)1.82273201
74Abnormality of the astrocytes (HP:0100707)1.81223522
75Astrocytoma (HP:0009592)1.81223522
76Pancreatic cysts (HP:0001737)1.80553917
77Gastrointestinal atresia (HP:0002589)1.80397251
78Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80161899
79Hypoglycemic coma (HP:0001325)1.79626586
80Ependymoma (HP:0002888)1.79438931
81Astigmatism (HP:0000483)1.78873117
82Birth length less than 3rd percentile (HP:0003561)1.78542607
83Aplasia/Hypoplasia of the earlobes (HP:0009906)1.77835247
84Increased CSF lactate (HP:0002490)1.77110200
85Increased hepatocellular lipid droplets (HP:0006565)1.76401919
86Abnormality of homocysteine metabolism (HP:0010919)1.75725831
87Homocystinuria (HP:0002156)1.75725831
88Absent radius (HP:0003974)1.75281632
89Dandy-Walker malformation (HP:0001305)1.75233382
90Sclerocornea (HP:0000647)1.75028529
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.74836562
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74713875
93Abnormality of alanine metabolism (HP:0010916)1.74713875
94Hyperalaninemia (HP:0003348)1.74713875
95Preaxial hand polydactyly (HP:0001177)1.74154806
96Thyroiditis (HP:0100646)1.73413195
97Small hand (HP:0200055)1.73283099
98White forelock (HP:0002211)1.72754581
99Papillary thyroid carcinoma (HP:0002895)1.72741940
100Meckel diverticulum (HP:0002245)1.72375736
101Neoplasm of the oral cavity (HP:0100649)1.72370476
102Abnormality of the pons (HP:0007361)1.72241487
103Lipid accumulation in hepatocytes (HP:0006561)1.71849038
104Aganglionic megacolon (HP:0002251)1.71518427
105Horseshoe kidney (HP:0000085)1.71512392
106Fair hair (HP:0002286)1.70743753
107Poor coordination (HP:0002370)1.70650010
108Vaginal atresia (HP:0000148)1.70224003
109Abnormality of DNA repair (HP:0003254)1.70100985
110Hypoplasia of the pons (HP:0012110)1.69234337
111Hyperinsulinemic hypoglycemia (HP:0000825)1.69081379
112Medulloblastoma (HP:0002885)1.68583824
113Blepharitis (HP:0000498)1.68126122
114Long clavicles (HP:0000890)1.66813507
115Clubbing of toes (HP:0100760)1.66601648
116Midline defect of the nose (HP:0004122)1.66379871
117Absent thumb (HP:0009777)1.66378792
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.66272576
119Abnormal lung lobation (HP:0002101)1.66214490
120Oligodactyly (hands) (HP:0001180)1.65736128
121Absent forearm bone (HP:0003953)1.65656095
122Aplasia involving forearm bones (HP:0009822)1.65656095
123Abnormality of the parietal bone (HP:0002696)1.65622966
124Urethral obstruction (HP:0000796)1.64584717
125Alveolar cell carcinoma (HP:0006519)1.64506331
126Tubulointerstitial nephritis (HP:0001970)1.63716466
127Highly arched eyebrow (HP:0002553)1.63478575
128Thyroid carcinoma (HP:0002890)1.62955802
129Anencephaly (HP:0002323)1.62497965
130Hypoplasia of the fovea (HP:0007750)1.62196449
131Aplasia/Hypoplasia of the fovea (HP:0008060)1.62196449
132Abnormality of the ileum (HP:0001549)1.62149825
133Abnormality of chromosome segregation (HP:0002916)1.61843871
134Hypoplastic labia majora (HP:0000059)1.61652624
135Optic nerve coloboma (HP:0000588)1.60150968
136Morphological abnormality of the middle ear (HP:0008609)1.59240294
137Progressive sensorineural hearing impairment (HP:0000408)1.58675449
138Optic neuritis (HP:0100653)1.56899101
139Retrobulbar optic neuritis (HP:0100654)1.56899101
140Capillary hemangiomas (HP:0005306)1.56606570
141Occipital encephalocele (HP:0002085)1.56469593
142Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.56178985
143Lymphoma (HP:0002665)1.56069916
144Median cleft lip (HP:0000161)1.55290117
145Metaphyseal dysplasia (HP:0100255)1.54267487
146Skull defect (HP:0001362)1.53796592
147Patchy hypopigmentation of hair (HP:0011365)1.53615273
148Mesomelia (HP:0003027)1.53509893
149Duodenal stenosis (HP:0100867)1.52415252
150Small intestinal stenosis (HP:0012848)1.52415252
151Long eyelashes (HP:0000527)1.52291937
152Abnormality of the intervertebral disk (HP:0005108)1.52290756
153Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.51722185
154Reticulocytopenia (HP:0001896)1.49452374
155T lymphocytopenia (HP:0005403)1.49309172
156Patellar aplasia (HP:0006443)1.47833087
157Ectropion (HP:0000656)1.47602267
158Increased number of teeth (HP:0011069)1.47363026
159Abnormality of the phalanges of the 5th finger (HP:0004213)1.46581241
160Hypochromic microcytic anemia (HP:0004840)1.46440316
161Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.45771379
162Protruding tongue (HP:0010808)1.45548717
163Abnormality of the labia majora (HP:0012881)1.44730327
164Anal stenosis (HP:0002025)1.44498383
165Chronic hepatic failure (HP:0100626)1.44189437
166Panhypogammaglobulinemia (HP:0003139)1.44186434
167Supernumerary bones of the axial skeleton (HP:0009144)1.44179946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.03798339
2MKNK13.99967745
3TNIK3.31856878
4NUAK12.96908104
5EIF2AK12.78984036
6IRAK42.66793693
7SRPK12.65938475
8BUB12.57307120
9BRD42.37401309
10ZAK2.37269592
11CDC72.28547514
12AKT32.11890258
13PNCK2.09251932
14NEK11.99413943
15WNK31.96248073
16ERBB31.84709732
17MAP4K21.83267392
18TRIM281.79484867
19TXK1.78073413
20PLK41.70890639
21MAP3K141.65544617
22TAF11.54720571
23TSSK61.41575918
24TRPM71.41403522
25MAP3K41.40175143
26OXSR11.38825699
27JAK31.31268114
28NEK61.31256171
29EIF2AK21.30477536
30FRK1.29182580
31YES11.28944529
32CDK121.28135658
33CLK11.25843682
34PBK1.24770562
35ATR1.23994798
36WNK41.22898158
37VRK11.21621294
38IRAK31.19255956
39CDK31.18115911
40TEC1.08980653
41ATM1.08447095
42PLK31.05296705
43MST41.05096118
44BRSK21.04350689
45INSRR1.03997093
46NEK21.02590400
47MAPK131.02336748
48BMPR21.01524280
49TTK1.01070333
50AURKB0.99010075
51NLK0.97474884
52LATS10.97220253
53VRK20.96457369
54STK40.94591707
55CHEK20.94318984
56CDK90.92913593
57SGK20.92889616
58CHUK0.92832507
59BRSK10.92139182
60PIK3CA0.90435990
61TAOK30.87402658
62STK100.86629777
63BMPR1B0.85709271
64CAMK1G0.83773703
65PLK20.83065872
66CCNB10.82334205
67NME10.81699523
68MELK0.81573805
69CDK60.79519423
70CHEK10.79491731
71STK30.79213370
72CSNK1G10.77782192
73STK38L0.77521997
74TGFBR20.77328633
75IRAK10.76805715
76RPS6KA50.74622597
77ITK0.74529816
78STK160.73369805
79PAK30.72855850
80EIF2AK30.71351713
81CASK0.71305560
82KIT0.69868027
83STK240.69297434
84ACVR1B0.69067092
85PASK0.67198215
86PLK10.65646004
87CSNK1A1L0.65644288
88ADRBK20.64018221
89CDK70.63210915
90CSNK1E0.62482445
91CSNK1G30.59826022
92BCR0.59394462
93IKBKB0.58917261
94FGFR20.58722761
95RPS6KB10.57433031
96CDK10.56898969
97FGFR30.56747133
98MAPKAPK50.55797673
99WEE10.55085216
100CSNK1G20.54068352
101MAP3K120.53611016
102GRK70.53395771
103RPS6KB20.52699345
104FGFR10.51910275
105RPS6KA40.51851278
106BTK0.51687600
107PIM10.50519338
108CSNK2A20.50466586
109IKBKE0.50299283
110LCK0.49061814
111CDK20.49024025
112GRK10.48673592
113TLK10.48103238
114LYN0.46830621
115STK390.46424079
116IRAK20.46086718
117* MAPK140.45505953
118PRKDC0.45347752
119PRKCE0.44722682
120WNK10.44632458
121MAP2K70.43902902
122CAMK1D0.43824649
123CDK80.43237403
124NTRK30.42470380
125DYRK20.42313342
126TGFBR10.42173462
127CSNK2A10.41408127
128DYRK30.41400960
129EPHA30.41250603
130NEK90.39856054
131AKT10.38869602
132SGK10.37617102
133PRKCQ0.37572423
134SGK30.36031749
135MAPK70.35865036
136PRKCI0.34699876
137CSNK1D0.33440476
138PDK20.30986125
139MINK10.29780603
140DMPK0.28261331
141MARK30.27739844

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.92565430
2Fanconi anemia pathway_Homo sapiens_hsa034602.31253590
3Proteasome_Homo sapiens_hsa030502.23753773
4Mismatch repair_Homo sapiens_hsa034302.20301223
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16815462
6Homologous recombination_Homo sapiens_hsa034402.07168500
7Propanoate metabolism_Homo sapiens_hsa006402.00274817
8* Spliceosome_Homo sapiens_hsa030401.88169592
9Basal transcription factors_Homo sapiens_hsa030221.87315292
10RNA degradation_Homo sapiens_hsa030181.83979969
11Selenocompound metabolism_Homo sapiens_hsa004501.82394956
12DNA replication_Homo sapiens_hsa030301.81171383
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76422323
14Cell cycle_Homo sapiens_hsa041101.73925505
15mRNA surveillance pathway_Homo sapiens_hsa030151.72321075
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.56229628
17Primary immunodeficiency_Homo sapiens_hsa053401.54935227
18Steroid biosynthesis_Homo sapiens_hsa001001.51651368
19Oxidative phosphorylation_Homo sapiens_hsa001901.51266136
20RNA polymerase_Homo sapiens_hsa030201.50405387
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49253261
22Base excision repair_Homo sapiens_hsa034101.47525350
23Butanoate metabolism_Homo sapiens_hsa006501.46624306
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.46208952
25Nucleotide excision repair_Homo sapiens_hsa034201.44735012
26Protein export_Homo sapiens_hsa030601.42564758
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42089828
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.37801273
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35351651
30* RNA transport_Homo sapiens_hsa030131.35094237
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34642838
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34098250
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34057927
34Autoimmune thyroid disease_Homo sapiens_hsa053201.31709929
35Herpes simplex infection_Homo sapiens_hsa051681.29393866
36Parkinsons disease_Homo sapiens_hsa050121.27120341
37Graft-versus-host disease_Homo sapiens_hsa053321.26122191
38Hematopoietic cell lineage_Homo sapiens_hsa046401.25727472
39Measles_Homo sapiens_hsa051621.22176676
40Oocyte meiosis_Homo sapiens_hsa041141.21051016
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19675559
42p53 signaling pathway_Homo sapiens_hsa041151.16444657
43Allograft rejection_Homo sapiens_hsa053301.14202972
44MicroRNAs in cancer_Homo sapiens_hsa052061.12179079
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.08202474
46Systemic lupus erythematosus_Homo sapiens_hsa053221.06848492
47Huntingtons disease_Homo sapiens_hsa050161.06537803
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06269464
49Prostate cancer_Homo sapiens_hsa052151.01157053
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98381184
51Antigen processing and presentation_Homo sapiens_hsa046120.97427368
52TGF-beta signaling pathway_Homo sapiens_hsa043500.97126914
53Small cell lung cancer_Homo sapiens_hsa052220.96345593
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94610562
55Pyruvate metabolism_Homo sapiens_hsa006200.92809314
56Phototransduction_Homo sapiens_hsa047440.92393684
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91754295
58Fatty acid elongation_Homo sapiens_hsa000620.90669951
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90373140
60T cell receptor signaling pathway_Homo sapiens_hsa046600.87992322
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.86907940
62ECM-receptor interaction_Homo sapiens_hsa045120.85872496
63Asthma_Homo sapiens_hsa053100.84269630
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84158125
65Epstein-Barr virus infection_Homo sapiens_hsa051690.82869342
66Ribosome_Homo sapiens_hsa030100.82573910
67Leishmaniasis_Homo sapiens_hsa051400.82548475
68Nitrogen metabolism_Homo sapiens_hsa009100.81386577
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81128296
70Viral carcinogenesis_Homo sapiens_hsa052030.80995703
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80715982
72HTLV-I infection_Homo sapiens_hsa051660.79481400
73B cell receptor signaling pathway_Homo sapiens_hsa046620.78227344
74Lysine degradation_Homo sapiens_hsa003100.77788207
75Vitamin B6 metabolism_Homo sapiens_hsa007500.77467726
76Colorectal cancer_Homo sapiens_hsa052100.76242611
77Hepatitis B_Homo sapiens_hsa051610.75853324
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75658561
79Influenza A_Homo sapiens_hsa051640.75417187
80Folate biosynthesis_Homo sapiens_hsa007900.74572292
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72537078
82Melanoma_Homo sapiens_hsa052180.71794169
83Malaria_Homo sapiens_hsa051440.71493232
84Pyrimidine metabolism_Homo sapiens_hsa002400.71272372
85Pathways in cancer_Homo sapiens_hsa052000.71152654
86Fatty acid metabolism_Homo sapiens_hsa012120.70417908
87Pancreatic cancer_Homo sapiens_hsa052120.69580044
88Toxoplasmosis_Homo sapiens_hsa051450.68082670
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67901023
90Olfactory transduction_Homo sapiens_hsa047400.66709267
91Adherens junction_Homo sapiens_hsa045200.66338524
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.65508826
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64935669
94Viral myocarditis_Homo sapiens_hsa054160.64461480
95Caffeine metabolism_Homo sapiens_hsa002320.63676027
96Chronic myeloid leukemia_Homo sapiens_hsa052200.62702794
97One carbon pool by folate_Homo sapiens_hsa006700.62386050
98Wnt signaling pathway_Homo sapiens_hsa043100.61888786
99Regulation of autophagy_Homo sapiens_hsa041400.61812419
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61580705
101Osteoclast differentiation_Homo sapiens_hsa043800.61441434
102Peroxisome_Homo sapiens_hsa041460.61285070
103Glutathione metabolism_Homo sapiens_hsa004800.61264697
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60805408
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60475893
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59486640
107TNF signaling pathway_Homo sapiens_hsa046680.58760574
108Sulfur metabolism_Homo sapiens_hsa009200.58714566
109Sphingolipid metabolism_Homo sapiens_hsa006000.58699531
110Alzheimers disease_Homo sapiens_hsa050100.58659980
111Notch signaling pathway_Homo sapiens_hsa043300.58611227
112Arachidonic acid metabolism_Homo sapiens_hsa005900.58311112
113Hepatitis C_Homo sapiens_hsa051600.57623949
114Chemokine signaling pathway_Homo sapiens_hsa040620.56640911
115Ether lipid metabolism_Homo sapiens_hsa005650.56487701
116Metabolic pathways_Homo sapiens_hsa011000.55761768
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55475175
118Platelet activation_Homo sapiens_hsa046110.55143384
119Focal adhesion_Homo sapiens_hsa045100.54411454
120FoxO signaling pathway_Homo sapiens_hsa040680.54190824
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54177249
122Basal cell carcinoma_Homo sapiens_hsa052170.54128869
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53822191
124Apoptosis_Homo sapiens_hsa042100.52905681
125Tryptophan metabolism_Homo sapiens_hsa003800.52600314
126Alcoholism_Homo sapiens_hsa050340.51495200
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50022541
128Purine metabolism_Homo sapiens_hsa002300.49129020
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49108296
130Type I diabetes mellitus_Homo sapiens_hsa049400.48494040
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46726923
132Acute myeloid leukemia_Homo sapiens_hsa052210.46232262
133Linoleic acid metabolism_Homo sapiens_hsa005910.46028088
134Nicotine addiction_Homo sapiens_hsa050330.45321367
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45072384
136Ras signaling pathway_Homo sapiens_hsa040140.43564224
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43372186
138Circadian rhythm_Homo sapiens_hsa047100.42752294
139Endometrial cancer_Homo sapiens_hsa052130.42066733
140African trypanosomiasis_Homo sapiens_hsa051430.41617107
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37395335
142Retinol metabolism_Homo sapiens_hsa008300.36894459
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36471534
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35900573
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.35152652
146Chemical carcinogenesis_Homo sapiens_hsa052040.33852530
147ABC transporters_Homo sapiens_hsa020100.32967786
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.32763373
149Vitamin digestion and absorption_Homo sapiens_hsa049770.29586521
150Fatty acid degradation_Homo sapiens_hsa000710.26589335
151beta-Alanine metabolism_Homo sapiens_hsa004100.26588905
152Hedgehog signaling pathway_Homo sapiens_hsa043400.24788766
153Taste transduction_Homo sapiens_hsa047420.23580750
154Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23015610
155Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22327115
156Fatty acid biosynthesis_Homo sapiens_hsa000610.21670511
157Hippo signaling pathway_Homo sapiens_hsa043900.19994795
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18946594
159N-Glycan biosynthesis_Homo sapiens_hsa005100.16085996
160Cardiac muscle contraction_Homo sapiens_hsa042600.15777010
161Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15671350
162Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13651442
163Fat digestion and absorption_Homo sapiens_hsa049750.13129479
164Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10143940

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