THOC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.86963377
2nucleobase biosynthetic process (GO:0046112)4.50338088
3DNA strand elongation involved in DNA replication (GO:0006271)4.31595585
4purine nucleobase biosynthetic process (GO:0009113)4.28263690
5protein localization to kinetochore (GO:0034501)4.25889291
6DNA unwinding involved in DNA replication (GO:0006268)4.25565618
7replication fork processing (GO:0031297)4.21372031
8folic acid-containing compound biosynthetic process (GO:0009396)4.17690706
9maturation of SSU-rRNA (GO:0030490)4.17643837
10DNA strand elongation (GO:0022616)4.08482542
11DNA replication initiation (GO:0006270)4.02246575
12behavioral response to nicotine (GO:0035095)3.99828736
13DNA replication-dependent nucleosome assembly (GO:0006335)3.95131551
14DNA replication-dependent nucleosome organization (GO:0034723)3.95131551
15DNA replication checkpoint (GO:0000076)3.92767857
16IMP biosynthetic process (GO:0006188)3.88430573
17regulation of hippo signaling (GO:0035330)3.87529199
18mitotic nuclear envelope disassembly (GO:0007077)3.82605892
19protein localization to chromosome, centromeric region (GO:0071459)3.81210663
20ribosome biogenesis (GO:0042254)3.80438116
21mitotic metaphase plate congression (GO:0007080)3.77509396
22nuclear pore organization (GO:0006999)3.76348097
23ribosomal small subunit assembly (GO:0000028)3.73738393
24spliceosomal snRNP assembly (GO:0000387)3.73636358
25regulation of nuclear cell cycle DNA replication (GO:0033262)3.69805936
26ribosome assembly (GO:0042255)3.69536508
27peptidyl-histidine modification (GO:0018202)3.65018207
28telomere maintenance via semi-conservative replication (GO:0032201)3.64054653
29nuclear pore complex assembly (GO:0051292)3.55346859
30membrane disassembly (GO:0030397)3.54136601
31nuclear envelope disassembly (GO:0051081)3.54136601
32double-strand break repair via nonhomologous end joining (GO:0006303)3.49473817
33non-recombinational repair (GO:0000726)3.49473817
34peptidyl-arginine omega-N-methylation (GO:0035247)3.48337052
35maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.47562674
36mitochondrial RNA metabolic process (GO:0000959)3.43890734
37ribonucleoprotein complex biogenesis (GO:0022613)3.43561887
38telomere maintenance via recombination (GO:0000722)3.41018599
39DNA strand renaturation (GO:0000733)3.40812898
40negative regulation of DNA-dependent DNA replication (GO:2000104)3.36437268
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.35476282
42NADH dehydrogenase complex assembly (GO:0010257)3.35476282
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35476282
44translational initiation (GO:0006413)3.34651869
45translational termination (GO:0006415)3.33251949
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.33049420
47histone arginine methylation (GO:0034969)3.32723321
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32163069
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.32163069
50DNA deamination (GO:0045006)3.31859199
51IMP metabolic process (GO:0046040)3.30395229
52viral transcription (GO:0019083)3.30193721
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29865126
54ribosomal large subunit biogenesis (GO:0042273)3.29239436
55regulation of rhodopsin mediated signaling pathway (GO:0022400)3.29107217
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28828942
57rRNA processing (GO:0006364)3.27618094
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26189311
59mitotic recombination (GO:0006312)3.25054216
60mitotic sister chromatid segregation (GO:0000070)3.24723961
61establishment of integrated proviral latency (GO:0075713)3.22115998
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21443156
63rRNA metabolic process (GO:0016072)3.20371955
64spliceosomal complex assembly (GO:0000245)3.20266588
65GMP metabolic process (GO:0046037)3.18858251
66translational elongation (GO:0006414)3.18644679
67double-strand break repair via homologous recombination (GO:0000724)3.17891467
68tRNA modification (GO:0006400)3.17741274
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17617982
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17409224
71termination of RNA polymerase III transcription (GO:0006386)3.16405967
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.16405967
73metaphase plate congression (GO:0051310)3.16108481
74mitochondrial respiratory chain complex assembly (GO:0033108)3.15032453
75recombinational repair (GO:0000725)3.14607756
76replicative senescence (GO:0090399)3.14565488
77regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14494485
78regulation of mitotic spindle checkpoint (GO:1903504)3.14494485
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14121705
80negative regulation of ligase activity (GO:0051352)3.14035861
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14035861
82regulation of posttranscriptional gene silencing (GO:0060147)3.13503123
83regulation of gene silencing by miRNA (GO:0060964)3.13503123
84regulation of gene silencing by RNA (GO:0060966)3.13503123
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13472302
86mRNA splicing, via spliceosome (GO:0000398)3.12093641
87RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.12093641
88RNA splicing, via transesterification reactions (GO:0000375)3.10833226
89DNA double-strand break processing (GO:0000729)3.10520203
90protein complex biogenesis (GO:0070271)3.10262602
91positive regulation of chromosome segregation (GO:0051984)3.09301642
92transcription elongation from RNA polymerase I promoter (GO:0006362)3.09228248
93rhodopsin mediated signaling pathway (GO:0016056)3.09131294
94ncRNA processing (GO:0034470)3.08561594
95telomere maintenance via telomere lengthening (GO:0010833)3.07615398
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06295444
97mitotic chromosome condensation (GO:0007076)3.06161171
98regulation of translational fidelity (GO:0006450)3.05641514
99rRNA catabolic process (GO:0016075)3.05632878
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04660543
101DNA geometric change (GO:0032392)3.04114428
102DNA duplex unwinding (GO:0032508)3.03915036
103regulation of centriole replication (GO:0046599)3.03300743
104nucleotide-excision repair, DNA gap filling (GO:0006297)3.02887148
105regulation of mitochondrial translation (GO:0070129)3.02310785
106ncRNA metabolic process (GO:0034660)3.00124271
107tRNA metabolic process (GO:0006399)2.99611311
108regulation of translational termination (GO:0006449)2.98866198
109sister chromatid segregation (GO:0000819)2.98845519
110tRNA processing (GO:0008033)2.97799798
111chromatin remodeling at centromere (GO:0031055)2.96371695
112negative regulation of chromosome segregation (GO:0051985)2.95927304
113tRNA methylation (GO:0030488)2.95287660
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95221247
115maturation of 5.8S rRNA (GO:0000460)2.94539409
116regulation of histone H3-K9 methylation (GO:0051570)2.93905136
117peptidyl-arginine methylation (GO:0018216)2.93850508
118peptidyl-arginine N-methylation (GO:0035246)2.93850508
119regulation of spindle organization (GO:0090224)2.93109798
120regulation of chromosome segregation (GO:0051983)2.92896952
121somatic diversification of immunoglobulins (GO:0016445)2.92853724
122regulation of centrosome cycle (GO:0046605)2.92548556
123negative regulation of mitotic sister chromatid separation (GO:2000816)2.91839247
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91839247
125negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91839247
126negative regulation of sister chromatid segregation (GO:0033046)2.91839247
127CENP-A containing nucleosome assembly (GO:0034080)2.91500464
128establishment of chromosome localization (GO:0051303)2.91098104
129transcription-coupled nucleotide-excision repair (GO:0006283)2.90618137
130ribosomal small subunit biogenesis (GO:0042274)2.90495210
131rRNA modification (GO:0000154)2.89508473
132amino acid activation (GO:0043038)2.88198978
133tRNA aminoacylation (GO:0043039)2.88198978
134histone exchange (GO:0043486)2.86490037
135mitotic spindle assembly checkpoint (GO:0007094)2.86013055
136tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85982899
137RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85982899
138pseudouridine synthesis (GO:0001522)2.85720015
139histone H2A acetylation (GO:0043968)2.84554986
140spindle checkpoint (GO:0031577)2.84078034
141cullin deneddylation (GO:0010388)2.83958752
142termination of RNA polymerase I transcription (GO:0006363)2.83653315
143G1/S transition of mitotic cell cycle (GO:0000082)2.83499761
144cell cycle G1/S phase transition (GO:0044843)2.83499761
145spindle assembly checkpoint (GO:0071173)2.83405148
146positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82682191
147DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82245320
148postreplication repair (GO:0006301)2.81907285
149reciprocal meiotic recombination (GO:0007131)2.81581878
150reciprocal DNA recombination (GO:0035825)2.81581878
151regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.78127591
152tRNA aminoacylation for protein translation (GO:0006418)2.76523095
153L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73730077
154DNA catabolic process, exonucleolytic (GO:0000738)2.73524497
155regulation of centrosome duplication (GO:0010824)2.71771775
156UTP biosynthetic process (GO:0006228)2.71227915
157cellular component biogenesis (GO:0044085)2.70986303
158transcription from RNA polymerase III promoter (GO:0006383)2.70944840
159histone mRNA metabolic process (GO:0008334)2.70869319
160somatic diversification of immune receptors (GO:0002200)2.70061022
161positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.69556239
162regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.69556239
163respiratory chain complex IV assembly (GO:0008535)2.68845377
164somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.68319116
165somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.68319116
166isotype switching (GO:0045190)2.68319116
167somatic recombination of immunoglobulin gene segments (GO:0016447)2.66921896
168ubiquinone biosynthetic process (GO:0006744)2.66279745
169DNA recombination (GO:0006310)2.65912669
170rRNA methylation (GO:0031167)2.63749270
171regulation of DNA endoreduplication (GO:0032875)2.63690851
172negative regulation of translation, ncRNA-mediated (GO:0040033)2.62324256
173regulation of translation, ncRNA-mediated (GO:0045974)2.62324256
174negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62324256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.40403029
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.26230288
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76175898
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.55939564
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31762896
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.25260357
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.24281608
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14704536
9ZNF274_21170338_ChIP-Seq_K562_Hela2.94394214
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93744822
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93678873
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.90697668
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90516144
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.87358761
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84805349
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74591665
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.66842431
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.61044494
19XRN2_22483619_ChIP-Seq_HELA_Human2.56207611
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54766547
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53049278
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42245411
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41250435
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28155723
25VDR_23849224_ChIP-Seq_CD4+_Human2.15893570
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05560686
27DCP1A_22483619_ChIP-Seq_HELA_Human2.05119213
28MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00294949
29* GABP_19822575_ChIP-Seq_HepG2_Human1.97873951
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94496005
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93669488
32FOXP3_21729870_ChIP-Seq_TREG_Human1.93344134
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88994054
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.88032918
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.84329458
36TTF2_22483619_ChIP-Seq_HELA_Human1.80968605
37AR_21909140_ChIP-Seq_LNCAP_Human1.80914521
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80693254
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.78139895
40MYC_22102868_ChIP-Seq_BL_Human1.77937733
41CIITA_25753668_ChIP-Seq_RAJI_Human1.74019095
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73595778
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70286394
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70251034
45* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68544103
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62049493
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.61720995
48IRF1_19129219_ChIP-ChIP_H3396_Human1.60940181
49KDM5A_27292631_Chip-Seq_BREAST_Human1.60636578
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59899330
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59741824
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59057839
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53458402
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53396943
55* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45336112
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.45334370
57* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44186819
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40147630
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38287234
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37374039
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33850142
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32297249
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.31832368
64* ELK1_19687146_ChIP-ChIP_HELA_Human1.30574963
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.30099731
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29908518
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29349601
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28261240
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26442803
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25064791
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24771383
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24370055
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23977037
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23833331
75TFEB_21752829_ChIP-Seq_HELA_Human1.20851196
76EWS_26573619_Chip-Seq_HEK293_Human1.20599951
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19912931
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17930006
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17148975
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15289841
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.14410850
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14382929
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12021146
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10923365
85* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09016766
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07605771
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07503847
88* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06786556
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.06564586
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05490089
91VDR_22108803_ChIP-Seq_LS180_Human1.04058221
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.02488411
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02290323
94TP53_22573176_ChIP-Seq_HFKS_Human1.01902146
95* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01584348
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00885090
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00829696
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00700054
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99722830
100* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99661312
101VDR_21846776_ChIP-Seq_THP-1_Human0.98719436
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98332962
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96937875
104* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95873320
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.95864447
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93760395
107* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93516701
108EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93114233
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91071376
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90812735
111MYC_18940864_ChIP-ChIP_HL60_Human0.89150891
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88294146
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88031084
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86229084
115YY1_22570637_ChIP-Seq_MALME-3M_Human0.83616625
116ZNF263_19887448_ChIP-Seq_K562_Human0.82552895
117FUS_26573619_Chip-Seq_HEK293_Human0.82203180
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80104028
119POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.79871804
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79839194
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79574534
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76893250
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75478667
124* ERA_21632823_ChIP-Seq_H3396_Human0.74940258
125* FOXP1_21924763_ChIP-Seq_HESCs_Human0.73428495
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.72966346
127HOXB7_26014856_ChIP-Seq_BT474_Human0.71684041
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70850101
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68876030
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.67226323
131* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.63049651
132IGF1R_20145208_ChIP-Seq_DFB_Human0.62887530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.24687936
2MP0010094_abnormal_chromosome_stability4.54762635
3MP0004957_abnormal_blastocyst_morpholog4.42601948
4MP0003111_abnormal_nucleus_morphology4.26943851
5MP0003077_abnormal_cell_cycle3.89987884
6MP0008057_abnormal_DNA_replication3.78597141
7MP0008058_abnormal_DNA_repair3.73567028
8MP0003646_muscle_fatigue3.68960247
9MP0008007_abnormal_cellular_replicative2.91983048
10MP0000569_abnormal_digit_pigmentation2.81702039
11MP0001730_embryonic_growth_arrest2.75208700
12MP0008932_abnormal_embryonic_tissue2.61062416
13MP0003011_delayed_dark_adaptation2.59474997
14MP0010352_gastrointestinal_tract_polyps2.50908301
15MP0008877_abnormal_DNA_methylation2.33008410
16MP0002102_abnormal_ear_morphology2.31273980
17MP0000350_abnormal_cell_proliferation2.29621108
18MP0001873_stomach_inflammation2.27257461
19MP0003123_paternal_imprinting2.25262079
20MP0005551_abnormal_eye_electrophysiolog2.05561411
21MP0006072_abnormal_retinal_apoptosis2.04283292
22MP0005253_abnormal_eye_physiology2.00107228
23MP0008995_early_reproductive_senescence1.97272363
24MP0010307_abnormal_tumor_latency1.94237021
25MP0001672_abnormal_embryogenesis/_devel1.90893852
26MP0005380_embryogenesis_phenotype1.90893852
27MP0001697_abnormal_embryo_size1.89034120
28MP0005410_abnormal_fertilization1.87821981
29MP0003786_premature_aging1.84907752
30MP0010030_abnormal_orbit_morphology1.82859286
31MP0002396_abnormal_hematopoietic_system1.81030256
32MP0002080_prenatal_lethality1.77420818
33MP0003984_embryonic_growth_retardation1.76955461
34MP0002088_abnormal_embryonic_growth/wei1.72172921
35MP0005394_taste/olfaction_phenotype1.71491033
36MP0005499_abnormal_olfactory_system1.71491033
37MP0003806_abnormal_nucleotide_metabolis1.70418994
38MP0002653_abnormal_ependyma_morphology1.69181832
39MP0004145_abnormal_muscle_electrophysio1.68431229
40MP0002938_white_spotting1.66103404
41MP0002085_abnormal_embryonic_tissue1.63522378
42MP0002084_abnormal_developmental_patter1.58965136
43MP0000537_abnormal_urethra_morphology1.56640174
44MP0005083_abnormal_biliary_tract1.56082044
45MP0002751_abnormal_autonomic_nervous1.55191750
46MP0008789_abnormal_olfactory_epithelium1.52689180
47MP0001929_abnormal_gametogenesis1.49272181
48MP0000372_irregular_coat_pigmentation1.48198240
49MP0009697_abnormal_copulation1.44932338
50MP0003186_abnormal_redox_activity1.44634732
51MP0002086_abnormal_extraembryonic_tissu1.44002420
52MP0000313_abnormal_cell_death1.42152055
53MP0002210_abnormal_sex_determination1.40363891
54MP0003937_abnormal_limbs/digits/tail_de1.37220254
55MP0003890_abnormal_embryonic-extraembry1.32692966
56MP0001661_extended_life_span1.31988618
57MP0003136_yellow_coat_color1.30752869
58MP0001986_abnormal_taste_sensitivity1.30087960
59MP0000427_abnormal_hair_cycle1.29701020
60MP0000490_abnormal_crypts_of1.29517521
61MP0008961_abnormal_basal_metabolism1.27985525
62MP0001145_abnormal_male_reproductive1.27407795
63MP0005391_vision/eye_phenotype1.26739634
64MP0004197_abnormal_fetal_growth/weight/1.26545557
65MP0002019_abnormal_tumor_incidence1.25812059
66MP0005174_abnormal_tail_pigmentation1.25098435
67MP0003718_maternal_effect1.23242754
68MP0003567_abnormal_fetal_cardiomyocyte1.23163151
69MP0003121_genomic_imprinting1.23005977
70MP0003698_abnormal_male_reproductive1.22789800
71MP0000358_abnormal_cell_content/1.20981564
72MP0004233_abnormal_muscle_weight1.19751831
73MP0004133_heterotaxia1.14933474
74MP0004142_abnormal_muscle_tone1.12805643
75MP0002095_abnormal_skin_pigmentation1.06177537
76MP0004808_abnormal_hematopoietic_stem1.04041172
77MP0000015_abnormal_ear_pigmentation1.02065530
78MP0000653_abnormal_sex_gland1.00595717
79MP0006292_abnormal_olfactory_placode1.00361116
80MP0002837_dystrophic_cardiac_calcinosis1.00037713
81MP0003315_abnormal_perineum_morphology0.99962484
82MP0006036_abnormal_mitochondrial_physio0.99911107
83MP0000371_diluted_coat_color0.96140056
84MP0005408_hypopigmentation0.95707874
85MP0009672_abnormal_birth_weight0.94682114
86MP0001286_abnormal_eye_development0.94244261
87MP0005389_reproductive_system_phenotype0.94117488
88MP0009333_abnormal_splenocyte_physiolog0.92250379
89MP0001119_abnormal_female_reproductive0.91584229
90MP0003119_abnormal_digestive_system0.91436055
91MP0005075_abnormal_melanosome_morpholog0.91413991
92MP0001293_anophthalmia0.90961740
93MP0002127_abnormal_cardiovascular_syste0.89594218
94MP0005076_abnormal_cell_differentiation0.89412524
95MP0000703_abnormal_thymus_morphology0.88968853
96MP0002161_abnormal_fertility/fecundity0.88525965
97MP0001529_abnormal_vocalization0.88373868
98MP0005171_absent_coat_pigmentation0.87663022
99MP0005023_abnormal_wound_healing0.86706304
100MP0005384_cellular_phenotype0.85341891
101MP0002638_abnormal_pupillary_reflex0.85085923
102MP0000538_abnormal_urinary_bladder0.84772868
103MP0005451_abnormal_body_composition0.83843524
104MP0005195_abnormal_posterior_eye0.83647946
105MP0002075_abnormal_coat/hair_pigmentati0.83226840
106MP0000647_abnormal_sebaceous_gland0.83110722
107MP0003950_abnormal_plasma_membrane0.83093222
108MP0005084_abnormal_gallbladder_morpholo0.82828766
109MP0001727_abnormal_embryo_implantation0.82584119
110MP0003221_abnormal_cardiomyocyte_apopto0.82278590
111MP0005397_hematopoietic_system_phenotyp0.81622459
112MP0001545_abnormal_hematopoietic_system0.81622459
113MP0003787_abnormal_imprinting0.81286702
114MP0001324_abnormal_eye_pigmentation0.79360705
115MP0001919_abnormal_reproductive_system0.78997902
116MP0002398_abnormal_bone_marrow0.77346019
117MP0003943_abnormal_hepatobiliary_system0.77103563
118MP0005360_urolithiasis0.76321596
119MP0005621_abnormal_cell_physiology0.75476605
120MP0000689_abnormal_spleen_morphology0.75244005
121MP0002722_abnormal_immune_system0.75219192
122MP0008872_abnormal_physiological_respon0.74225455
123MP0003941_abnormal_skin_development0.74100259
124MP0005266_abnormal_metabolism0.73997186
125MP0002160_abnormal_reproductive_system0.72597849
126MP0003763_abnormal_thymus_physiology0.72224963
127MP0003195_calcinosis0.71949672
128MP0001835_abnormal_antigen_presentation0.71494039
129MP0001915_intracranial_hemorrhage0.71326834
130MP0001186_pigmentation_phenotype0.69152575
131MP0000750_abnormal_muscle_regeneration0.68331392
132MP0002269_muscular_atrophy0.66920817
133MP0005501_abnormal_skin_physiology0.66454691
134MP0001764_abnormal_homeostasis0.65706511
135MP0000858_altered_metastatic_potential0.65474024
136MP0003861_abnormal_nervous_system0.64609060
137MP0008770_decreased_survivor_rate0.63790227
138MP0003566_abnormal_cell_adhesion0.62050600
139MP0006035_abnormal_mitochondrial_morpho0.62030918
140MP0009703_decreased_birth_body0.61453273
141MP0002429_abnormal_blood_cell0.61412496
142MP0003705_abnormal_hypodermis_morpholog0.57845318
143MP0002111_abnormal_tail_morphology0.56625782
144MP0004264_abnormal_extraembryonic_tissu0.56366339
145MP0003115_abnormal_respiratory_system0.54209965

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.27357776
2Bony spicule pigmentary retinopathy (HP:0007737)4.27802053
3Ependymoma (HP:0002888)4.15020595
4Birth length less than 3rd percentile (HP:0003561)4.05661146
5Abnormality of alanine metabolism (HP:0010916)3.97204907
6Hyperalaninemia (HP:0003348)3.97204907
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.97204907
8Selective tooth agenesis (HP:0001592)3.95783394
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.81215008
10Abnormal rod and cone electroretinograms (HP:0008323)3.79763149
11Degeneration of anterior horn cells (HP:0002398)3.78690238
12Abnormality of the anterior horn cell (HP:0006802)3.78690238
13Cerebral hypomyelination (HP:0006808)3.70265583
14Oral leukoplakia (HP:0002745)3.63433853
15Pendular nystagmus (HP:0012043)3.51457942
16Abnormality of the labia minora (HP:0012880)3.51252768
17Pancreatic cysts (HP:0001737)3.34572360
18Breast hypoplasia (HP:0003187)3.26518373
19Abnormality of cells of the erythroid lineage (HP:0012130)3.24725183
20Abnormality of the pons (HP:0007361)3.18890592
21Pigmentary retinal degeneration (HP:0001146)3.13312935
22Reticulocytopenia (HP:0001896)3.12607677
23Abnormality of DNA repair (HP:0003254)3.12337314
24Abnormality of midbrain morphology (HP:0002418)3.11443715
25Molar tooth sign on MRI (HP:0002419)3.11443715
26Abnormal number of erythroid precursors (HP:0012131)3.09836373
27Increased CSF lactate (HP:0002490)2.99904356
28Hypoplasia of the pons (HP:0012110)2.99407231
29Colon cancer (HP:0003003)2.96366256
30Patellar aplasia (HP:0006443)2.93865798
31Rough bone trabeculation (HP:0100670)2.89766148
32Type II lissencephaly (HP:0007260)2.89049960
33Pancreatic fibrosis (HP:0100732)2.84251086
34Attenuation of retinal blood vessels (HP:0007843)2.83441119
35Increased serum lactate (HP:0002151)2.82318520
36Astrocytoma (HP:0009592)2.81401395
37Abnormality of the astrocytes (HP:0100707)2.81401395
38Aplasia/Hypoplasia of the patella (HP:0006498)2.80323338
39Agnosia (HP:0010524)2.76067930
40Medulloblastoma (HP:0002885)2.73137501
41Atrophy/Degeneration involving motor neurons (HP:0007373)2.70460903
42Ectopic kidney (HP:0000086)2.70327023
43Cerebellar dysplasia (HP:0007033)2.67311454
44Impulsivity (HP:0100710)2.63440633
45Carpal bone hypoplasia (HP:0001498)2.62681515
46Neoplasm of the adrenal cortex (HP:0100641)2.61208445
47Type II diabetes mellitus (HP:0005978)2.60964112
48Increased hepatocellular lipid droplets (HP:0006565)2.60018159
49Duplicated collecting system (HP:0000081)2.54884956
50Acute necrotizing encephalopathy (HP:0006965)2.50959373
51Lipid accumulation in hepatocytes (HP:0006561)2.49897263
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.48414189
53Mitochondrial inheritance (HP:0001427)2.47295805
54Neonatal hypoglycemia (HP:0001998)2.46214640
55Nephronophthisis (HP:0000090)2.44602967
56Trismus (HP:0000211)2.42562265
57Deviation of the thumb (HP:0009603)2.42380163
58Abnormal number of incisors (HP:0011064)2.41638357
59Proximal placement of thumb (HP:0009623)2.40472757
60Severe visual impairment (HP:0001141)2.38317947
61Pancreatic islet-cell hyperplasia (HP:0004510)2.36243467
62Acute encephalopathy (HP:0006846)2.34436921
63Chorioretinal atrophy (HP:0000533)2.34027364
64Abnormality of the lower motor neuron (HP:0002366)2.32669748
65Type I transferrin isoform profile (HP:0003642)2.31679047
66Glioma (HP:0009733)2.31027200
67Abnormality of the preputium (HP:0100587)2.30653650
68Personality changes (HP:0000751)2.30589818
69Homocystinuria (HP:0002156)2.30280685
70Abnormality of homocysteine metabolism (HP:0010919)2.30280685
71Hepatocellular necrosis (HP:0001404)2.29209378
72Neoplasm of the pancreas (HP:0002894)2.28296746
73Multiple enchondromatosis (HP:0005701)2.27956502
74Abnormality of the renal collecting system (HP:0004742)2.24131149
75Pallor (HP:0000980)2.23470431
76Cellular immunodeficiency (HP:0005374)2.21263829
77Abnormal mitochondria in muscle tissue (HP:0008316)2.21194819
78Abnormal glycosylation (HP:0012345)2.21143953
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21143953
80Abnormal protein N-linked glycosylation (HP:0012347)2.21143953
81Abnormal protein glycosylation (HP:0012346)2.21143953
82Prominent nose (HP:0000448)2.19788495
83Bile duct proliferation (HP:0001408)2.18482629
84Abnormal biliary tract physiology (HP:0012439)2.18482629
85Abnormality of the renal cortex (HP:0011035)2.18295988
86Progressive inability to walk (HP:0002505)2.17626126
87Renal cortical cysts (HP:0000803)2.16945033
8811 pairs of ribs (HP:0000878)2.16780708
89Abnormality of the carotid arteries (HP:0005344)2.16638871
90Large for gestational age (HP:0001520)2.15615631
91Lissencephaly (HP:0001339)2.15258379
92Chronic hepatic failure (HP:0100626)2.14304289
93Meckel diverticulum (HP:0002245)2.12966634
94Abnormality of the ileum (HP:0001549)2.11062017
95CNS hypomyelination (HP:0003429)2.08154430
96True hermaphroditism (HP:0010459)2.08027624
97Horseshoe kidney (HP:0000085)2.07480520
98Renal Fanconi syndrome (HP:0001994)2.06261251
99Hepatic necrosis (HP:0002605)2.05643113
100Increased serum pyruvate (HP:0003542)2.05495168
101Abnormality of glycolysis (HP:0004366)2.05495168
102Abnormality of chromosome stability (HP:0003220)2.03844923
103Severe muscular hypotonia (HP:0006829)2.03795882
104Small intestinal stenosis (HP:0012848)2.03642614
105Duodenal stenosis (HP:0100867)2.03642614
106Microretrognathia (HP:0000308)2.03199603
107Macrocytic anemia (HP:0001972)2.02314447
108Absent radius (HP:0003974)2.01749110
109Cutaneous melanoma (HP:0012056)2.00434684
110Overlapping toe (HP:0001845)1.99432741
111Myelodysplasia (HP:0002863)1.99382423
112Abnormality of abdominal situs (HP:0011620)1.99027752
113Abdominal situs inversus (HP:0003363)1.99027752
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.98453694
115Basal cell carcinoma (HP:0002671)1.97120817
116Photophobia (HP:0000613)1.95842656
117Sloping forehead (HP:0000340)1.94942382
118Chromsome breakage (HP:0040012)1.94747590
119Amyotrophic lateral sclerosis (HP:0007354)1.94479984
120Abnormal trabecular bone morphology (HP:0100671)1.94111865
121Small hand (HP:0200055)1.93231705
122Cleft eyelid (HP:0000625)1.93077155
123Sparse lateral eyebrow (HP:0005338)1.93012687
124Bone marrow hypocellularity (HP:0005528)1.92775738
125Squamous cell carcinoma (HP:0002860)1.92527282
126Bilateral microphthalmos (HP:0007633)1.91382831
127Lactic acidosis (HP:0003128)1.91273611
128Poikiloderma (HP:0001029)1.89907094
129Abnormality of methionine metabolism (HP:0010901)1.89431763
130Increased nuchal translucency (HP:0010880)1.89193534
131Entropion (HP:0000621)1.88655972
132Hyperventilation (HP:0002883)1.88447726
133Absent thumb (HP:0009777)1.88236303
134Tracheoesophageal fistula (HP:0002575)1.88166305
135Cystic liver disease (HP:0006706)1.88145306
136Abnormality of the renal medulla (HP:0100957)1.87875570
137Rhabdomyosarcoma (HP:0002859)1.87256401
1383-Methylglutaconic aciduria (HP:0003535)1.85938962
139Premature ovarian failure (HP:0008209)1.85864163
140Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85083716
141Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85083716
142Abnormal lung lobation (HP:0002101)1.84789551
143Atresia of the external auditory canal (HP:0000413)1.84239132
144Premature graying of hair (HP:0002216)1.84142736
145Neoplasm of striated muscle (HP:0009728)1.82117658
146Postnatal microcephaly (HP:0005484)1.82011629
147Dandy-Walker malformation (HP:0001305)1.81281918
148Aplastic anemia (HP:0001915)1.81194249
149Optic nerve coloboma (HP:0000588)1.81127722
150High anterior hairline (HP:0009890)1.81087190
151Progressive macrocephaly (HP:0004481)1.79985815
152Clubbing of toes (HP:0100760)1.79825861
153Aplasia involving forearm bones (HP:0009822)1.79556109
154Absent forearm bone (HP:0003953)1.79556109
155Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79443066
156Adenoma sebaceum (HP:0009720)1.79435459
157Angiofibromas (HP:0010615)1.79435459
158Emotional lability (HP:0000712)1.78839074
159Preaxial hand polydactyly (HP:0001177)1.78277074
160Short thumb (HP:0009778)1.77458543
161Sclerocornea (HP:0000647)1.76498603
162Facial hemangioma (HP:0000329)1.75023481
163Concave nail (HP:0001598)1.74839164
164Cafe-au-lait spot (HP:0000957)1.74532919
165Facial cleft (HP:0002006)1.73802995
166Abnormality of the motor neurons (HP:0002450)1.73667933
167Abnormal neuron morphology (HP:0012757)1.73667933
168Abnormality of serum amino acid levels (HP:0003112)1.73556756
169Respiratory difficulties (HP:0002880)1.73191019
170Pelvic girdle muscle weakness (HP:0003749)1.72434420
171Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72152927
172Inability to walk (HP:0002540)1.70294701
173Abnormality of the duodenum (HP:0002246)1.70219957
174Optic disc pallor (HP:0000543)1.68748918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.17860246
2CDC73.91413078
3WEE13.71674694
4FRK3.34446066
5NEK13.06970466
6BMPR1B3.05365692
7TSSK62.92157826
8CCNB12.90078224
9NEK22.88347706
10NUAK12.45159280
11RPS6KB22.38246342
12TESK22.34337961
13EEF2K2.30747873
14TAF12.29151345
15EIF2AK12.28955138
16SRPK12.28891388
17TTK2.20670985
18WNK42.20509559
19TESK12.17950999
20VRK22.15988339
21PLK11.89506220
22CDK121.88091008
23TLK11.82715526
24PBK1.74207748
25PLK31.73065339
26PASK1.72223189
27VRK11.71697645
28AKT31.69264445
29MAP3K101.68982321
30ADRBK21.67890779
31IRAK41.63672961
32CDK81.61155716
33EPHA21.60726424
34ATR1.60700906
35SCYL21.56428545
36CDK71.55897503
37PAK41.55521051
38NME21.50384588
39PDK31.47564534
40PDK41.47564534
41CHEK21.41570282
42BRSK21.38286799
43PNCK1.37343211
44CHEK11.36916784
45AURKB1.35873822
46AURKA1.32877166
47EIF2AK31.30371657
48RPS6KA41.26991001
49GRK11.22558332
50ACVR1B1.20670114
51MAP3K81.17303302
52STK101.16685526
53CDK41.13059689
54STK161.12900822
55MKNK11.12537126
56MARK31.08993876
57ALK1.08008007
58BRSK11.06728639
59WNK31.05381604
60CAMK1D1.04981242
61FLT31.04000798
62MAPKAPK31.02331096
63MUSK1.02250558
64DYRK31.01812393
65TAOK20.98587889
66PLK40.93759858
67PAK10.93649445
68ICK0.93546777
69CDK20.93468958
70TXK0.91470593
71MAP4K20.84975105
72INSRR0.82841187
73TNK20.82505629
74ATM0.79845449
75MAP2K30.77788462
76NME10.75528270
77WNK10.73878120
78STK40.73830622
79PRKCI0.72734615
80MAP3K110.71774735
81PKN20.71636008
82CSNK2A20.70070015
83MAP4K10.68811871
84DYRK20.68785913
85MAP2K60.67603333
86CDK10.67571133
87CAMK1G0.67003447
88MST40.65715135
89LIMK10.65702525
90ILK0.64432048
91MAP2K70.64220968
92DAPK10.63586174
93CSNK1G10.61172745
94MKNK20.61171248
95TGFBR10.60988516
96PDK20.60670979
97ADRBK10.59905472
98CSNK1A1L0.58889416
99EIF2AK20.58875483
100MAP3K40.58575489
101MTOR0.58334546
102CSNK1G30.57514162
103CSNK2A10.57304784
104IRAK10.56806216
105ZAK0.55411972
106TAOK30.55211174
107AKT20.55190885
108PAK30.54245467
109SMG10.53345872
110LRRK20.53126420
111TRIM280.51838846
112KDR0.50684690
113MAPK110.50532096
114GRK60.50503990
115PIM10.49764535
116PIK3CG0.49598645
117CSNK1E0.48807639
118RPS6KA50.46058911
119LATS20.43686144
120CDK60.43320033
121BRD40.43121019
122CDK180.42514742
123CDK90.41201969
124ZAP700.40998620
125CDK11A0.39758079
126CDK150.39583889
127PHKG20.38452729
128PHKG10.38452729
129MAPK90.34818745
130CDK140.34783301
131PRKDC0.34216548
132RPS6KA10.32603907
133CSNK1D0.32424781
134ERBB40.30696627
135RPS6KB10.30367316
136MAP2K40.28479333
137STK30.27416595
138PAK20.26442039
139MAPK140.25943100
140TRIB30.24648252
141SIK30.23819666
142MELK0.23485340
143DAPK30.23428794
144BLK0.22465156
145FGFR10.22464223

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.32273553
2Phototransduction_Homo sapiens_hsa047444.05772485
3Mismatch repair_Homo sapiens_hsa034303.84659167
4Proteasome_Homo sapiens_hsa030503.75114998
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73487036
6Spliceosome_Homo sapiens_hsa030403.52625771
7* RNA transport_Homo sapiens_hsa030133.36337867
8RNA polymerase_Homo sapiens_hsa030203.32584601
9Ribosome_Homo sapiens_hsa030103.08222145
10Base excision repair_Homo sapiens_hsa034103.04758071
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77036850
12One carbon pool by folate_Homo sapiens_hsa006702.60472074
13Cell cycle_Homo sapiens_hsa041102.56414737
14Nucleotide excision repair_Homo sapiens_hsa034202.52139787
15Pyrimidine metabolism_Homo sapiens_hsa002402.33317351
16Homologous recombination_Homo sapiens_hsa034402.25243350
17Non-homologous end-joining_Homo sapiens_hsa034502.14729836
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10647384
19Basal transcription factors_Homo sapiens_hsa030222.06756244
20mRNA surveillance pathway_Homo sapiens_hsa030151.90850344
21RNA degradation_Homo sapiens_hsa030181.86422893
22Fanconi anemia pathway_Homo sapiens_hsa034601.69377622
23Biosynthesis of amino acids_Homo sapiens_hsa012301.51837650
24Purine metabolism_Homo sapiens_hsa002301.47217083
25Nitrogen metabolism_Homo sapiens_hsa009101.45437445
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44356475
27Regulation of autophagy_Homo sapiens_hsa041401.42123128
28p53 signaling pathway_Homo sapiens_hsa041151.33520650
29Lysine degradation_Homo sapiens_hsa003101.32736288
30Pentose phosphate pathway_Homo sapiens_hsa000301.31341387
31Epstein-Barr virus infection_Homo sapiens_hsa051691.30446676
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.29305250
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24250520
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23784633
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.20011835
36Systemic lupus erythematosus_Homo sapiens_hsa053221.19836437
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15142289
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14267811
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10711357
40Oocyte meiosis_Homo sapiens_hsa041141.10427815
41Propanoate metabolism_Homo sapiens_hsa006401.06294270
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04948416
43Vitamin B6 metabolism_Homo sapiens_hsa007501.04892480
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.03759868
45Carbon metabolism_Homo sapiens_hsa012001.03045597
46Fructose and mannose metabolism_Homo sapiens_hsa000511.01555939
47Viral carcinogenesis_Homo sapiens_hsa052030.90316132
48Antigen processing and presentation_Homo sapiens_hsa046120.88711722
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88001436
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84668104
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82007870
52Huntingtons disease_Homo sapiens_hsa050160.79207038
53Butanoate metabolism_Homo sapiens_hsa006500.75492601
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74888279
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74248177
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73934362
57Linoleic acid metabolism_Homo sapiens_hsa005910.70541152
58Peroxisome_Homo sapiens_hsa041460.66468616
59Sulfur relay system_Homo sapiens_hsa041220.65672168
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64685809
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.64403309
62HTLV-I infection_Homo sapiens_hsa051660.62668781
63Selenocompound metabolism_Homo sapiens_hsa004500.61654915
64Tryptophan metabolism_Homo sapiens_hsa003800.58546944
65Herpes simplex infection_Homo sapiens_hsa051680.58328406
66Steroid biosynthesis_Homo sapiens_hsa001000.57185587
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56886393
68Galactose metabolism_Homo sapiens_hsa000520.56858464
69Parkinsons disease_Homo sapiens_hsa050120.56143547
70Ether lipid metabolism_Homo sapiens_hsa005650.53656261
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53296318
72Folate biosynthesis_Homo sapiens_hsa007900.49516704
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48631529
74Alcoholism_Homo sapiens_hsa050340.48121828
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47374462
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47358778
77Glutathione metabolism_Homo sapiens_hsa004800.47276305
78Vitamin digestion and absorption_Homo sapiens_hsa049770.47063689
79TGF-beta signaling pathway_Homo sapiens_hsa043500.46264893
80N-Glycan biosynthesis_Homo sapiens_hsa005100.45306942
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44467172
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43500176
83Fat digestion and absorption_Homo sapiens_hsa049750.42643352
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.39422695
85Pyruvate metabolism_Homo sapiens_hsa006200.38627400
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38322216
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.33746652
88Oxidative phosphorylation_Homo sapiens_hsa001900.33335273
89Legionellosis_Homo sapiens_hsa051340.32838164
90Caffeine metabolism_Homo sapiens_hsa002320.32524115
91HIF-1 signaling pathway_Homo sapiens_hsa040660.31481812
92Notch signaling pathway_Homo sapiens_hsa043300.30934482
93Hippo signaling pathway_Homo sapiens_hsa043900.29029925
94mTOR signaling pathway_Homo sapiens_hsa041500.28935921
95ABC transporters_Homo sapiens_hsa020100.28313224
96Shigellosis_Homo sapiens_hsa051310.28223147
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26860952
98Olfactory transduction_Homo sapiens_hsa047400.26331983
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25505112
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25232085
101Primary immunodeficiency_Homo sapiens_hsa053400.24722161
102Colorectal cancer_Homo sapiens_hsa052100.22610657
103Taste transduction_Homo sapiens_hsa047420.22501094
104Apoptosis_Homo sapiens_hsa042100.21162765
105Small cell lung cancer_Homo sapiens_hsa052220.20984401
106MicroRNAs in cancer_Homo sapiens_hsa052060.20956294
107Metabolic pathways_Homo sapiens_hsa011000.20821938
108Sulfur metabolism_Homo sapiens_hsa009200.19045864
109Viral myocarditis_Homo sapiens_hsa054160.18984739
110Thyroid cancer_Homo sapiens_hsa052160.18589055
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17192595
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16725044
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15269581
114Protein export_Homo sapiens_hsa030600.11072845
115Glucagon signaling pathway_Homo sapiens_hsa049220.10431177
116Basal cell carcinoma_Homo sapiens_hsa052170.10002132
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09582538
118Fatty acid metabolism_Homo sapiens_hsa012120.09476000
119Glycerolipid metabolism_Homo sapiens_hsa005610.09393037
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08568493
121Measles_Homo sapiens_hsa051620.07746854
122Tight junction_Homo sapiens_hsa045300.06880676
123Retinol metabolism_Homo sapiens_hsa008300.04373269
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.01601887
125Synaptic vesicle cycle_Homo sapiens_hsa047210.00522815
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.00461733
127Hepatitis B_Homo sapiens_hsa051610.00249167
128Influenza A_Homo sapiens_hsa05164-0.0757741
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0643816
130Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0438814
131Pathways in cancer_Homo sapiens_hsa05200-0.0396352
132Cardiac muscle contraction_Homo sapiens_hsa04260-0.0312715
133Renin-angiotensin system_Homo sapiens_hsa04614-0.0177377
134Alzheimers disease_Homo sapiens_hsa05010-0.0053003

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