THOC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription and export of mRNAs. A missense mutation in this gene is associated with a neurodevelopmental disorder called Beaulieu-Boycott-Innes syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.46559226
2DNA strand elongation involved in DNA replication (GO:0006271)4.71487797
3maturation of SSU-rRNA (GO:0030490)4.67989234
4telomere maintenance via semi-conservative replication (GO:0032201)4.58767770
5formation of translation preinitiation complex (GO:0001731)4.52707912
6DNA strand elongation (GO:0022616)4.51463542
7DNA replication initiation (GO:0006270)4.34497772
8DNA deamination (GO:0045006)4.23882439
9ribosomal small subunit biogenesis (GO:0042274)4.17192711
10DNA replication checkpoint (GO:0000076)4.09509008
11telomere maintenance via recombination (GO:0000722)4.05732938
12viral transcription (GO:0019083)3.96588587
13nucleobase biosynthetic process (GO:0046112)3.95863430
14ribosomal large subunit biogenesis (GO:0042273)3.91836016
15ribonucleoprotein complex biogenesis (GO:0022613)3.91769824
16translational termination (GO:0006415)3.89041830
17establishment of integrated proviral latency (GO:0075713)3.88411955
18protein localization to kinetochore (GO:0034501)3.88385433
19ribosome biogenesis (GO:0042254)3.87741310
20purine nucleobase biosynthetic process (GO:0009113)3.82831077
21CENP-A containing nucleosome assembly (GO:0034080)3.82592063
22IMP biosynthetic process (GO:0006188)3.81519139
23DNA unwinding involved in DNA replication (GO:0006268)3.81514972
24mitotic metaphase plate congression (GO:0007080)3.80290301
25mitotic recombination (GO:0006312)3.79854540
26regulation of mitochondrial translation (GO:0070129)3.74111166
27chromatin remodeling at centromere (GO:0031055)3.72273178
28proteasome assembly (GO:0043248)3.69267006
29telomere maintenance via telomere lengthening (GO:0010833)3.65230060
30translational elongation (GO:0006414)3.60857482
31protein maturation by protein folding (GO:0022417)3.55786388
32translational initiation (GO:0006413)3.55212556
33ribosome assembly (GO:0042255)3.53690953
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.51530935
35spliceosomal snRNP assembly (GO:0000387)3.51169527
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49487059
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43279695
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42811754
39establishment of viral latency (GO:0019043)3.41704093
40rRNA processing (GO:0006364)3.39808846
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37287901
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36627571
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.36627571
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.35887052
45DNA replication-independent nucleosome assembly (GO:0006336)3.35556785
46DNA replication-independent nucleosome organization (GO:0034724)3.35556785
47peptidyl-arginine omega-N-methylation (GO:0035247)3.35257469
48kinetochore organization (GO:0051383)3.35236432
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34656040
50metaphase plate congression (GO:0051310)3.34192548
51IMP metabolic process (GO:0046040)3.33934181
52pentose-phosphate shunt (GO:0006098)3.33537429
53cotranslational protein targeting to membrane (GO:0006613)3.33092423
54protein localization to chromosome, centromeric region (GO:0071459)3.32171136
55protein targeting to ER (GO:0045047)3.31828687
56negative regulation of B cell apoptotic process (GO:0002903)3.31023489
57proline biosynthetic process (GO:0006561)3.30288913
58kinetochore assembly (GO:0051382)3.28275310
59* viral mRNA export from host cell nucleus (GO:0046784)3.27643968
60rRNA metabolic process (GO:0016072)3.27073244
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26884096
62mitotic nuclear envelope disassembly (GO:0007077)3.26067042
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24950314
64folic acid-containing compound biosynthetic process (GO:0009396)3.24748663
65attachment of spindle microtubules to kinetochore (GO:0008608)3.24583224
66DNA replication-dependent nucleosome organization (GO:0034723)3.23408155
67DNA replication-dependent nucleosome assembly (GO:0006335)3.23408155
68purine nucleotide salvage (GO:0032261)3.22472105
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22261804
70negative regulation of ligase activity (GO:0051352)3.19122231
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.19122231
72regulation of translational termination (GO:0006449)3.18878592
73rRNA modification (GO:0000154)3.18498733
74transcription-coupled nucleotide-excision repair (GO:0006283)3.18498531
75nucleotide salvage (GO:0043173)3.17999337
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17668210
77regulation of double-strand break repair via homologous recombination (GO:0010569)3.15419635
78metallo-sulfur cluster assembly (GO:0031163)3.14292304
79iron-sulfur cluster assembly (GO:0016226)3.14292304
80protein localization to endoplasmic reticulum (GO:0070972)3.13706482
81translation (GO:0006412)3.12342418
82establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11493245
83pseudouridine synthesis (GO:0001522)3.10885462
84NADPH regeneration (GO:0006740)3.10769950
85establishment of chromosome localization (GO:0051303)3.10549059
86viral life cycle (GO:0019058)3.10360863
87cellular protein complex disassembly (GO:0043624)3.05918822
88G1/S transition of mitotic cell cycle (GO:0000082)3.05835902
89cell cycle G1/S phase transition (GO:0044843)3.05835902
90deoxyribonucleotide catabolic process (GO:0009264)3.05295358
91histone arginine methylation (GO:0034969)3.03863200
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02666082
93deoxyribose phosphate catabolic process (GO:0046386)3.02198567
94tRNA methylation (GO:0030488)3.01857643
95histone exchange (GO:0043486)2.99778051
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98809282
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98809282
98nuclear envelope disassembly (GO:0051081)2.98671084
99membrane disassembly (GO:0030397)2.98671084
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98631246
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98631246
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98631246
103nuclear envelope reassembly (GO:0031468)2.97715517
104mitotic nuclear envelope reassembly (GO:0007084)2.97715517
105cellular component biogenesis (GO:0044085)2.96993133
106negative regulation of mRNA processing (GO:0050686)2.95561655
107signal transduction involved in DNA damage checkpoint (GO:0072422)2.93010548
108signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93010548
109purine deoxyribonucleotide catabolic process (GO:0009155)2.91030087
110protein K6-linked ubiquitination (GO:0085020)2.90972319
111glucose catabolic process (GO:0006007)2.90394874
112maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89224049
113base-excision repair (GO:0006284)2.89080279
114regulation of nuclear cell cycle DNA replication (GO:0033262)2.88904036
115signal transduction involved in cell cycle checkpoint (GO:0072395)2.88872388
116termination of RNA polymerase III transcription (GO:0006386)2.87127978
117transcription elongation from RNA polymerase III promoter (GO:0006385)2.87127978
118regulation of spindle organization (GO:0090224)2.87113057
119pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.86367714
1207-methylguanosine mRNA capping (GO:0006370)2.86001290
121mismatch repair (GO:0006298)2.85777956
122exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85514847
123spliceosomal complex assembly (GO:0000245)2.84702433
124Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84569715
125telomere organization (GO:0032200)2.83628693
1267-methylguanosine RNA capping (GO:0009452)2.83012629
127RNA capping (GO:0036260)2.83012629
128positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82792567
129nucleobase-containing small molecule interconversion (GO:0015949)2.80926672
130pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.80575427
131pentose metabolic process (GO:0019321)2.79707286
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78621452
133pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.77855420
134regulation of cellular amino acid metabolic process (GO:0006521)2.77641177
135rRNA transcription (GO:0009303)2.74179089
136pinocytosis (GO:0006907)2.73648051
137negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73018826
138DNA ligation (GO:0006266)2.71879860
139negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.68435747
140peptidyl-arginine methylation (GO:0018216)2.66483044
141peptidyl-arginine N-methylation (GO:0035246)2.66483044
142positive regulation of ligase activity (GO:0051351)2.65266238
143pyrimidine nucleotide catabolic process (GO:0006244)2.64697004
144mitochondrial RNA metabolic process (GO:0000959)2.64502282
145negative regulation of RNA splicing (GO:0033119)2.64446168
146antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.64211747
147negative regulation of mRNA metabolic process (GO:1903312)2.64203631
148GDP-mannose metabolic process (GO:0019673)2.62237726
149deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.62077467
150pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.61880491
151nucleoside salvage (GO:0043174)2.61176736
152base-excision repair, AP site formation (GO:0006285)2.60094171
153mitochondrial calcium ion transport (GO:0006851)2.55040748
154guanosine-containing compound biosynthetic process (GO:1901070)2.54603358
155regulation of translational fidelity (GO:0006450)2.53998119
156regulation of ubiquitin-protein transferase activity (GO:0051438)2.51942330
157regulation of B cell apoptotic process (GO:0002902)2.48883705
158regulation of ligase activity (GO:0051340)2.47278254
159CTP metabolic process (GO:0046036)2.45822632

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.73955191
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20774900
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70696937
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.37478401
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.32236321
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25239674
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.23015621
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00525700
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98693633
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.98156769
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91840880
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.89507864
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86174934
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84193426
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74113999
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64643373
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59723265
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32885959
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32090823
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29413545
21VDR_23849224_ChIP-Seq_CD4+_Human2.27620353
22* XRN2_22483619_ChIP-Seq_HELA_Human2.26037436
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08120078
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02934395
25DCP1A_22483619_ChIP-Seq_HELA_Human2.02437990
26FOXP3_21729870_ChIP-Seq_TREG_Human2.00785228
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92200551
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91508162
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89201034
30GABP_19822575_ChIP-Seq_HepG2_Human1.88838427
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88019371
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87102373
33TTF2_22483619_ChIP-Seq_HELA_Human1.78294864
34* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78151155
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77843754
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74716983
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.72988996
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70042345
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.69042755
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68916485
41AR_21909140_ChIP-Seq_LNCAP_Human1.68822088
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66159614
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65436349
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65029203
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59896071
46CIITA_25753668_ChIP-Seq_RAJI_Human1.59597533
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59361104
48* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59027604
49ELK1_19687146_ChIP-ChIP_HELA_Human1.58845873
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57872549
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.55506500
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51184829
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50233531
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49743991
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48130009
56MYC_22102868_ChIP-Seq_BL_Human1.47846422
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45649153
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43527420
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40758311
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.38863134
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36980222
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33147916
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.32167692
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32066168
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30617928
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29607430
67* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29067128
68KDM5A_27292631_Chip-Seq_BREAST_Human1.28868506
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28856129
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.25754822
71ZNF263_19887448_ChIP-Seq_K562_Human1.24647989
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24306143
73LXR_22292898_ChIP-Seq_THP-1_Human1.23980219
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23409723
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.22989507
76* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22795994
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20286641
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.17503815
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.16242054
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15841028
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14875594
82* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13121932
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12697376
84* MAF_26560356_Chip-Seq_TH1_Human1.12652391
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12036702
86UTX_26944678_Chip-Seq_JUKART_Human1.11873425
87P68_20966046_ChIP-Seq_HELA_Human1.11569413
88TFEB_21752829_ChIP-Seq_HELA_Human1.09768106
89* SPI1_23547873_ChIP-Seq_NB4_Human1.08995530
90MAF_26560356_Chip-Seq_TH2_Human1.08538263
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07763169
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07763169
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07763169
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07664615
95* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07330498
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07237808
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05012402
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04145996
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03832013
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03133574
101ELK1_22589737_ChIP-Seq_MCF10A_Human1.02084956
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02010179
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.01461370
104* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01288670
105BCOR_27268052_Chip-Seq_Bcells_Human1.01179570
106RACK7_27058665_Chip-Seq_MCF-7_Human1.01168439
107* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00425822
108VDR_21846776_ChIP-Seq_THP-1_Human0.99974788
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99875235
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99201599
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99130738
112* NCOR1_26117541_ChIP-Seq_K562_Human0.98378327
113BCL6_27268052_Chip-Seq_Bcells_Human0.98371620
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.95141725
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94788641
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93591513
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93195845
118MYC_18940864_ChIP-ChIP_HL60_Human0.92660677
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90647884
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87058050
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86727548
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85446166
123SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84074643
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82925071
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81309635
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80074662
127NANOG_21062744_ChIP-ChIP_HESCs_Human0.79459813
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77673393
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77154993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.65305454
2MP0010094_abnormal_chromosome_stability4.51928526
3MP0003111_abnormal_nucleus_morphology4.38574617
4MP0004957_abnormal_blastocyst_morpholog4.35121686
5MP0003077_abnormal_cell_cycle3.89594126
6MP0008057_abnormal_DNA_replication3.38265052
7MP0008058_abnormal_DNA_repair3.23327581
8MP0008007_abnormal_cellular_replicative2.82928829
9MP0005058_abnormal_lysosome_morphology2.66119607
10MP0008932_abnormal_embryonic_tissue2.57404907
11MP0002396_abnormal_hematopoietic_system2.45595591
12MP0005451_abnormal_body_composition2.20796529
13MP0003786_premature_aging2.07162142
14MP0001730_embryonic_growth_arrest2.06887461
15MP0000350_abnormal_cell_proliferation2.05687927
16MP0008877_abnormal_DNA_methylation2.02476189
17MP0002254_reproductive_system_inflammat1.94839599
18MP0009840_abnormal_foam_cell1.90732568
19MP0003718_maternal_effect1.86159954
20MP0003806_abnormal_nucleotide_metabolis1.83898108
21MP0003123_paternal_imprinting1.83689321
22MP0010352_gastrointestinal_tract_polyps1.81145880
23MP0000490_abnormal_crypts_of1.80441937
24MP0001545_abnormal_hematopoietic_system1.64822746
25MP0005397_hematopoietic_system_phenotyp1.64822746
26MP0009333_abnormal_splenocyte_physiolog1.64375327
27MP0003191_abnormal_cellular_cholesterol1.63558725
28MP0006035_abnormal_mitochondrial_morpho1.57340000
29MP0002019_abnormal_tumor_incidence1.52122856
30MP0002796_impaired_skin_barrier1.50234457
31MP0009697_abnormal_copulation1.49701860
32MP0005380_embryogenesis_phenotype1.49229807
33MP0001672_abnormal_embryogenesis/_devel1.49229807
34MP0000313_abnormal_cell_death1.48126191
35MP0001697_abnormal_embryo_size1.47836785
36MP0003186_abnormal_redox_activity1.45434279
37MP0002080_prenatal_lethality1.43674060
38MP0010030_abnormal_orbit_morphology1.43054657
39MP0004808_abnormal_hematopoietic_stem1.37419543
40MP0003315_abnormal_perineum_morphology1.34846253
41MP0003984_embryonic_growth_retardation1.34713135
42MP0003763_abnormal_thymus_physiology1.33694650
43MP0003567_abnormal_fetal_cardiomyocyte1.33489871
44MP0002088_abnormal_embryonic_growth/wei1.31971320
45MP0002398_abnormal_bone_marrow1.31434790
46MP0005464_abnormal_platelet_physiology1.30855902
47MP0010307_abnormal_tumor_latency1.29505609
48MP0004133_heterotaxia1.27196278
49MP0000689_abnormal_spleen_morphology1.24949958
50MP0002085_abnormal_embryonic_tissue1.22392602
51MP0005075_abnormal_melanosome_morpholog1.22130810
52MP0002722_abnormal_immune_system1.21099149
53MP0002086_abnormal_extraembryonic_tissu1.20198251
54MP0002132_abnormal_respiratory_system1.18043585
55MP0001849_ear_inflammation1.16597500
56MP0000703_abnormal_thymus_morphology1.14019733
57MP0001835_abnormal_antigen_presentation1.13620153
58MP0003283_abnormal_digestive_organ1.10050426
59MP0003656_abnormal_erythrocyte_physiolo1.09703502
60MP0000678_abnormal_parathyroid_gland1.09343240
61MP0002429_abnormal_blood_cell1.09206479
62MP0002210_abnormal_sex_determination1.08073430
63MP0002084_abnormal_developmental_patter1.07743407
64MP0002877_abnormal_melanocyte_morpholog1.07438010
65MP0000858_altered_metastatic_potential1.06998141
66MP0004185_abnormal_adipocyte_glucose1.06026803
67MP0004197_abnormal_fetal_growth/weight/1.04903651
68MP0006292_abnormal_olfactory_placode1.04146898
69MP0004947_skin_inflammation1.04138802
70MP0000716_abnormal_immune_system1.00610636
71MP0001873_stomach_inflammation0.98604857
72MP0002160_abnormal_reproductive_system0.96850551
73MP0001145_abnormal_male_reproductive0.95986700
74MP0001293_anophthalmia0.94479507
75MP0001727_abnormal_embryo_implantation0.93813762
76MP0001800_abnormal_humoral_immune0.91838894
77MP0002452_abnormal_antigen_presenting0.91233387
78MP0008469_abnormal_protein_level0.90907056
79MP0001881_abnormal_mammary_gland0.89786111
80MP0001845_abnormal_inflammatory_respons0.88928829
81MP0002420_abnormal_adaptive_immunity0.88727068
82MP0001819_abnormal_immune_cell0.87694117
83MP0001119_abnormal_female_reproductive0.87562438
84MP0001790_abnormal_immune_system0.87514454
85MP0005387_immune_system_phenotype0.87514454
86MP0006082_CNS_inflammation0.87149936
87MP0003303_peritoneal_inflammation0.86885266
88MP0005330_cardiomyopathy0.84279470
89MP0001853_heart_inflammation0.83709979
90MP0005389_reproductive_system_phenotype0.82928991
91MP0009379_abnormal_foot_pigmentation0.82721765
92MP0009764_decreased_sensitivity_to0.82527576
93MP0009278_abnormal_bone_marrow0.81886831
94MP0009785_altered_susceptibility_to0.81850309
95MP0005076_abnormal_cell_differentiation0.81346314
96MP0009931_abnormal_skin_appearance0.80785816
97MP0003075_altered_response_to0.80264291
98MP0003221_abnormal_cardiomyocyte_apopto0.78970318
99MP0001929_abnormal_gametogenesis0.78905156
100MP0000358_abnormal_cell_content/0.78843182
101MP0002405_respiratory_system_inflammati0.78813014
102MP0003121_genomic_imprinting0.78757143
103MP0000653_abnormal_sex_gland0.78431558
104MP0009672_abnormal_birth_weight0.78243236
105MP0005023_abnormal_wound_healing0.76894470
106MP0002723_abnormal_immune_serum0.76123899
107MP0004782_abnormal_surfactant_physiolog0.74965550
108MP0005671_abnormal_response_to0.74770092
109MP0003453_abnormal_keratinocyte_physiol0.74762603
110MP0004147_increased_porphyrin_level0.74713964
111MP0005000_abnormal_immune_tolerance0.73543758
112MP0000598_abnormal_liver_morphology0.73506115
113MP0003890_abnormal_embryonic-extraembry0.73214277
114MP0003941_abnormal_skin_development0.73066437
115MP0005025_abnormal_response_to0.72960587
116MP0005384_cellular_phenotype0.72897686
117MP0003436_decreased_susceptibility_to0.71703112
118MP0000465_gastrointestinal_hemorrhage0.71164911
119MP0005621_abnormal_cell_physiology0.71034401
120MP0003566_abnormal_cell_adhesion0.70372019
121MP0006036_abnormal_mitochondrial_physio0.67608208
122MP0002148_abnormal_hypersensitivity_rea0.65641985
123MP0000685_abnormal_immune_system0.63205181
124MP0000477_abnormal_intestine_morphology0.62716620
125MP0001919_abnormal_reproductive_system0.59202512
126MP0002111_abnormal_tail_morphology0.58653553
127MP0010155_abnormal_intestine_physiology0.58561050
128MP0005501_abnormal_skin_physiology0.58442253
129MP0003448_altered_tumor_morphology0.56204271
130MP0001764_abnormal_homeostasis0.55329212
131MP0000343_altered_response_to0.54755221
132MP0005174_abnormal_tail_pigmentation0.54649156
133MP0002419_abnormal_innate_immunity0.54477079
134MP0008260_abnormal_autophagy0.53714021

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.14158579
2Reticulocytopenia (HP:0001896)4.93568491
3Breast hypoplasia (HP:0003187)4.33212239
4Abnormality of cells of the erythroid lineage (HP:0012130)4.28048711
5Abnormal number of erythroid precursors (HP:0012131)4.04353645
6Carpal bone hypoplasia (HP:0001498)3.84319158
7Chromsome breakage (HP:0040012)3.72194250
8Colon cancer (HP:0003003)3.68105411
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63467586
10Ragged-red muscle fibers (HP:0003200)3.61343341
11Patellar aplasia (HP:0006443)3.36443645
12Progressive muscle weakness (HP:0003323)3.22704456
13Selective tooth agenesis (HP:0001592)3.20788590
14Agnosia (HP:0010524)3.19426147
15Absent thumb (HP:0009777)3.19339841
16Aplasia/Hypoplasia of the patella (HP:0006498)3.12732997
17Oral leukoplakia (HP:0002745)3.11380407
18Rough bone trabeculation (HP:0100670)3.07640254
19Pallor (HP:0000980)3.02894262
20Cerebral hypomyelination (HP:0006808)2.95804792
21Abnormality of the preputium (HP:0100587)2.95367025
22Vacuolated lymphocytes (HP:0001922)2.94847333
23Macrocytic anemia (HP:0001972)2.90070553
24Abnormality of the anterior horn cell (HP:0006802)2.89804979
25Degeneration of anterior horn cells (HP:0002398)2.89804979
26Meckel diverticulum (HP:0002245)2.89524702
27Vertebral compression fractures (HP:0002953)2.84487747
28Aplastic anemia (HP:0001915)2.83376382
29Duplicated collecting system (HP:0000081)2.81845241
30Abnormality of the ileum (HP:0001549)2.81761336
31Increased cerebral lipofuscin (HP:0011813)2.80624719
32Absent radius (HP:0003974)2.77327393
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.76497986
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70539480
35Trismus (HP:0000211)2.68946121
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68096747
37Ependymoma (HP:0002888)2.66143858
38Cholecystitis (HP:0001082)2.66105050
39Abnormal gallbladder physiology (HP:0012438)2.66105050
40Abnormality of chromosome stability (HP:0003220)2.63789581
41Abnormality of glycolipid metabolism (HP:0010969)2.61529119
42Abnormality of liposaccharide metabolism (HP:0010968)2.61529119
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.61529119
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.60873229
45Increased IgM level (HP:0003496)2.60299409
46Progressive external ophthalmoplegia (HP:0000590)2.58024266
47Increased intramyocellular lipid droplets (HP:0012240)2.56429851
48Medulloblastoma (HP:0002885)2.54423015
49Absent forearm bone (HP:0003953)2.53329571
50Aplasia involving forearm bones (HP:0009822)2.53329571
51Bone marrow hypocellularity (HP:0005528)2.52895975
52Entropion (HP:0000621)2.50895578
53Microretrognathia (HP:0000308)2.47999666
54Hepatosplenomegaly (HP:0001433)2.47612485
55Type I transferrin isoform profile (HP:0003642)2.46992596
56Multiple enchondromatosis (HP:0005701)2.46875390
57Increased muscle lipid content (HP:0009058)2.45499535
5811 pairs of ribs (HP:0000878)2.44473736
59Myelodysplasia (HP:0002863)2.40509181
60Increased serum ferritin (HP:0003281)2.40433102
61Abnormal mitochondria in muscle tissue (HP:0008316)2.38026738
62Abnormality of the renal collecting system (HP:0004742)2.37613149
63Premature graying of hair (HP:0002216)2.36709545
643-Methylglutaconic aciduria (HP:0003535)2.36432836
65Small intestinal stenosis (HP:0012848)2.34568248
66Duodenal stenosis (HP:0100867)2.34568248
67Elevated erythrocyte sedimentation rate (HP:0003565)2.31360148
68Hepatic necrosis (HP:0002605)2.31192159
69Mediastinal lymphadenopathy (HP:0100721)2.28847341
70Cellular immunodeficiency (HP:0005374)2.28194722
71Abnormal lung lobation (HP:0002101)2.27234569
72Thrombocytosis (HP:0001894)2.27024690
73Neoplasm of the pancreas (HP:0002894)2.26938000
74Triphalangeal thumb (HP:0001199)2.25505774
75Impulsivity (HP:0100710)2.24948179
76Ectopic kidney (HP:0000086)2.24756505
77Amaurosis fugax (HP:0100576)2.24740921
78Abnormal trabecular bone morphology (HP:0100671)2.24661060
79Lymphoma (HP:0002665)2.20803328
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20225334
81Centrally nucleated skeletal muscle fibers (HP:0003687)2.16435066
82Tracheoesophageal fistula (HP:0002575)2.16027298
83Recurrent abscess formation (HP:0002722)2.15547099
84Progressive neurologic deterioration (HP:0002344)2.15322240
85Loss of speech (HP:0002371)2.15017216
86Mitochondrial inheritance (HP:0001427)2.14655964
87Rhabdomyosarcoma (HP:0002859)2.14477304
88Ureteral duplication (HP:0000073)2.14393680
89Microvesicular hepatic steatosis (HP:0001414)2.13497459
90Cerebral palsy (HP:0100021)2.12680858
91Optic nerve coloboma (HP:0000588)2.12625223
92Hypertensive crisis (HP:0100735)2.11806330
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11351583
94Dicarboxylic aciduria (HP:0003215)2.11351583
95Pancytopenia (HP:0001876)2.11219456
96Sloping forehead (HP:0000340)2.11212777
97Increased CSF lactate (HP:0002490)2.10980858
98Poikiloderma (HP:0001029)2.08657638
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08208947
100Abnormal protein N-linked glycosylation (HP:0012347)2.08208947
101Abnormal protein glycosylation (HP:0012346)2.08208947
102Abnormal glycosylation (HP:0012345)2.08208947
103Agammaglobulinemia (HP:0004432)2.08170168
104Secondary amenorrhea (HP:0000869)2.07563308
105Increased serum lactate (HP:0002151)2.07058624
106Premature ovarian failure (HP:0008209)2.05978534
107Recurrent viral infections (HP:0004429)2.05698517
108Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03461378
109Lactic acidosis (HP:0003128)2.02582649
110IgM deficiency (HP:0002850)2.01676880
111Irregular epiphyses (HP:0010582)2.00520312
112Gastrointestinal dysmotility (HP:0002579)1.98565594
113Supernumerary spleens (HP:0009799)1.98471253
114Exercise intolerance (HP:0003546)1.95935913
115Testicular atrophy (HP:0000029)1.95367759
116Petechiae (HP:0000967)1.95089902
117Abnormality of pyrimidine metabolism (HP:0004353)1.94589793
118Increased IgE level (HP:0003212)1.93117145
119Abnormality of the duodenum (HP:0002246)1.92641671
120Obstructive lung disease (HP:0006536)1.92439667
121Chronic obstructive pulmonary disease (HP:0006510)1.92439667
122Cleft eyelid (HP:0000625)1.91951968
123Granulocytopenia (HP:0001913)1.91498177
124Atresia of the external auditory canal (HP:0000413)1.91069187
125Reduced antithrombin III activity (HP:0001976)1.91010727
126Neoplasm of the colon (HP:0100273)1.90218985
127Abnormality of DNA repair (HP:0003254)1.89771011
128Clubbing of toes (HP:0100760)1.89671872
129Abnormality of macrophages (HP:0004311)1.89666237
130* Horseshoe kidney (HP:0000085)1.89468347
131Abnormality of the umbilical cord (HP:0010881)1.88782828
132Abnormal number of incisors (HP:0011064)1.88618994
133Nonimmune hydrops fetalis (HP:0001790)1.88461559
134Death in infancy (HP:0001522)1.87690645
135Acute encephalopathy (HP:0006846)1.87167574
136Autoimmune thrombocytopenia (HP:0001973)1.85906609
137Combined immunodeficiency (HP:0005387)1.85795423
138Basal cell carcinoma (HP:0002671)1.85771216
139Fasciculations (HP:0002380)1.84120970
140Rectal fistula (HP:0100590)1.84073832
141Rectovaginal fistula (HP:0000143)1.84073832
142Asplenia (HP:0001746)1.83909688
143Stenosis of the external auditory canal (HP:0000402)1.83300071
144Panhypogammaglobulinemia (HP:0003139)1.83183067
145Cellulitis (HP:0100658)1.82444416
146Muscle fiber atrophy (HP:0100295)1.82393913
147Sparse eyelashes (HP:0000653)1.82011821
148Biconcave vertebral bodies (HP:0004586)1.81538416
149Hypergonadotropic hypogonadism (HP:0000815)1.80494299
150Acute necrotizing encephalopathy (HP:0006965)1.80460671
151Abnormality of reticulocytes (HP:0004312)1.78954555
152Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78837352
153Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78837352
154Abnormality of iron homeostasis (HP:0011031)1.78395266
155Slender long bone (HP:0003100)1.78149634
156Aplasia/Hypoplasia of the thymus (HP:0010515)1.76932607
157Short thumb (HP:0009778)1.76359839
158Type 2 muscle fiber atrophy (HP:0003554)1.75785969
159Hypoplasia of the radius (HP:0002984)1.74687893
160Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74508293
161Orthostatic hypotension (HP:0001278)1.74054500
162Autoimmune hemolytic anemia (HP:0001890)1.74030178
163Poor head control (HP:0002421)1.73653775
164Hepatocellular necrosis (HP:0001404)1.72585681
165Abnormality of the heme biosynthetic pathway (HP:0010472)1.71223147
166Single umbilical artery (HP:0001195)1.71159267
167Respiratory difficulties (HP:0002880)1.70450243
168Reticulocytosis (HP:0001923)1.70128578
169Opisthotonus (HP:0002179)1.68700470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.07456277
2VRK24.28768912
3WEE13.72750680
4CDC73.02956770
5EIF2AK12.98618810
6SMG12.61307248
7PLK42.51870553
8EIF2AK32.51847772
9SRPK12.45337772
10BRSK22.42166746
11TTK2.28538940
12NME22.25274595
13BCKDK2.20355277
14NEK22.17407275
15ERN12.10918036
16TSSK62.04696899
17PLK11.93496428
18TESK21.88736743
19STK161.85767465
20RPS6KB21.82009460
21PASK1.78430454
22VRK11.75341885
23EPHA21.70472549
24NEK11.66582226
25MKNK11.65804270
26AURKB1.62484237
27CDK71.59203120
28ATR1.51965065
29BRD41.47118788
30TAOK21.45663281
31BRSK11.43643150
32ACVR1B1.43049027
33DAPK11.41798944
34PLK31.40099307
35ZAK1.39539168
36SCYL21.32811481
37AURKA1.31448733
38IRAK31.31265718
39STK41.30940997
40DYRK31.30777993
41PIM21.29148574
42TLK11.28273233
43PIM11.27047930
44TRIB31.23277390
45STK101.22701553
46ARAF1.21956460
47CDK41.21468355
48CHEK21.20259768
49RPS6KA41.18079600
50MAP4K11.16614999
51BLK1.16441839
52PBK1.15153861
53MAP3K81.14488043
54TBK11.07771619
55MAP3K101.04805989
56MKNK21.04286904
57IRAK41.03053528
58CHEK10.97964563
59KDR0.96747197
60MAP2K30.90707337
61EIF2AK20.89763386
62MST40.87816934
63TESK10.87255705
64TGFBR10.85440148
65MAP2K20.83090707
66ABL20.81820071
67PRPF4B0.81635120
68ZAP700.81075795
69STK38L0.80168669
70TAF10.79224822
71PAK40.79106974
72CCNB10.76425666
73CSNK2A10.75924928
74FLT30.71923804
75BTK0.71346884
76CSNK2A20.71324572
77JAK30.69101245
78CDK120.68470397
79DYRK20.67733799
80CDK20.67619210
81EEF2K0.66721993
82PAK10.66648522
83PRKCI0.65979343
84TEC0.65193744
85ATM0.64621933
86IKBKB0.63200084
87LMTK20.62823941
88BRAF0.60408547
89DAPK30.59908071
90LRRK20.59209073
91MATK0.55795751
92CDK80.55725005
93RPS6KA50.53828466
94YES10.53751279
95MAP3K110.53659137
96PRKG20.52982413
97BMX0.51142802
98CLK10.50526096
99MAPK110.50331219
100CSNK1G30.49919883
101MAP3K60.48153772
102TAOK30.47569039
103MAP3K30.47369090
104MAPKAPK20.45083175
105CDK10.45058904
106RAF10.43943281
107CHUK0.41918099
108NME10.41828961
109KIT0.41163244
110MAPKAPK30.41037828
111TXK0.40665386
112CDK90.40522198
113LIMK10.40461384
114STK240.39789843
115PDK20.38843115
116MAP3K50.38813823
117ALK0.37934545
118MAP3K140.37148476
119NLK0.36748575
120LYN0.35392991
121RPS6KL10.35056811
122RPS6KC10.35056811
123CSF1R0.35049090
124TYK20.35016514
125ICK0.34816944
126SYK0.34224851
127ILK0.31491359
128MELK0.30734285
129NEK90.29931153
130RPS6KA60.28548815
131GRK60.28400610

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.81142631
2Mismatch repair_Homo sapiens_hsa034304.31522603
3Ribosome_Homo sapiens_hsa030103.95399494
4Proteasome_Homo sapiens_hsa030503.76632212
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42830584
6RNA polymerase_Homo sapiens_hsa030203.29165392
7Base excision repair_Homo sapiens_hsa034103.20097480
8Spliceosome_Homo sapiens_hsa030403.18194048
9Homologous recombination_Homo sapiens_hsa034403.00427108
10* RNA transport_Homo sapiens_hsa030132.80227323
11Nucleotide excision repair_Homo sapiens_hsa034202.70195801
12Pyrimidine metabolism_Homo sapiens_hsa002402.55187998
13Cell cycle_Homo sapiens_hsa041102.40216167
14One carbon pool by folate_Homo sapiens_hsa006702.35484812
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31565120
16Non-homologous end-joining_Homo sapiens_hsa034502.19524280
17Fanconi anemia pathway_Homo sapiens_hsa034602.18556889
18Basal transcription factors_Homo sapiens_hsa030221.88820716
19RNA degradation_Homo sapiens_hsa030181.82844503
20p53 signaling pathway_Homo sapiens_hsa041151.48155284
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42904533
22Purine metabolism_Homo sapiens_hsa002301.38919369
23mRNA surveillance pathway_Homo sapiens_hsa030151.34305625
24Epstein-Barr virus infection_Homo sapiens_hsa051691.17248446
25Protein export_Homo sapiens_hsa030601.13904588
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12957847
27Fatty acid elongation_Homo sapiens_hsa000621.11341042
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10610540
29Primary immunodeficiency_Homo sapiens_hsa053400.94615586
30Folate biosynthesis_Homo sapiens_hsa007900.93559485
31Herpes simplex infection_Homo sapiens_hsa051680.89659961
32Systemic lupus erythematosus_Homo sapiens_hsa053220.88915373
33Lysosome_Homo sapiens_hsa041420.87713898
34Antigen processing and presentation_Homo sapiens_hsa046120.84348742
35Glycosaminoglycan degradation_Homo sapiens_hsa005310.83735511
36Pentose phosphate pathway_Homo sapiens_hsa000300.80320255
37Pyruvate metabolism_Homo sapiens_hsa006200.78516160
38Legionellosis_Homo sapiens_hsa051340.75611769
39Autoimmune thyroid disease_Homo sapiens_hsa053200.74013166
40Parkinsons disease_Homo sapiens_hsa050120.73409492
41Huntingtons disease_Homo sapiens_hsa050160.71466747
42Viral carcinogenesis_Homo sapiens_hsa052030.70485315
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.70436880
44Sulfur relay system_Homo sapiens_hsa041220.70098724
45Graft-versus-host disease_Homo sapiens_hsa053320.69878216
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68679857
47Viral myocarditis_Homo sapiens_hsa054160.67946910
48Oocyte meiosis_Homo sapiens_hsa041140.65300957
49Biosynthesis of amino acids_Homo sapiens_hsa012300.65091688
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64419372
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.63546072
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63445383
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.62410500
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58022444
55Thyroid cancer_Homo sapiens_hsa052160.56454335
56HTLV-I infection_Homo sapiens_hsa051660.56425473
57Oxidative phosphorylation_Homo sapiens_hsa001900.56324270
58Glutathione metabolism_Homo sapiens_hsa004800.55674041
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54178823
60Vitamin B6 metabolism_Homo sapiens_hsa007500.54153811
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.53982511
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.52572510
63Apoptosis_Homo sapiens_hsa042100.51916627
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50121083
65Fructose and mannose metabolism_Homo sapiens_hsa000510.47813598
66N-Glycan biosynthesis_Homo sapiens_hsa005100.47441736
67Salmonella infection_Homo sapiens_hsa051320.47204730
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46832908
69Shigellosis_Homo sapiens_hsa051310.46732885
70Selenocompound metabolism_Homo sapiens_hsa004500.46383796
71Rheumatoid arthritis_Homo sapiens_hsa053230.45426980
72Galactose metabolism_Homo sapiens_hsa000520.44430102
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44227370
74Measles_Homo sapiens_hsa051620.43783580
75Arachidonic acid metabolism_Homo sapiens_hsa005900.43642160
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41289172
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41122995
78Hematopoietic cell lineage_Homo sapiens_hsa046400.41001178
79Type I diabetes mellitus_Homo sapiens_hsa049400.40933143
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40769980
81Carbon metabolism_Homo sapiens_hsa012000.39534473
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39120923
83MicroRNAs in cancer_Homo sapiens_hsa052060.39005749
84Other glycan degradation_Homo sapiens_hsa005110.38329447
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37920233
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.36814617
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36262479
88Sulfur metabolism_Homo sapiens_hsa009200.36029306
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35124845
90Small cell lung cancer_Homo sapiens_hsa052220.35089490
91Leishmaniasis_Homo sapiens_hsa051400.34230043
92Tuberculosis_Homo sapiens_hsa051520.33969389
93Metabolic pathways_Homo sapiens_hsa011000.31997658
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31795119
95Notch signaling pathway_Homo sapiens_hsa043300.31368897
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31244848
97Chronic myeloid leukemia_Homo sapiens_hsa052200.30697039
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29466847
99Asthma_Homo sapiens_hsa053100.29016451
100Peroxisome_Homo sapiens_hsa041460.28255337
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27986976
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26879109
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26125092
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24653336
105Influenza A_Homo sapiens_hsa051640.24089269
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23878125
107Acute myeloid leukemia_Homo sapiens_hsa052210.21318786
108Hepatitis B_Homo sapiens_hsa051610.21236581
109TGF-beta signaling pathway_Homo sapiens_hsa043500.19727034
110HIF-1 signaling pathway_Homo sapiens_hsa040660.19298310
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16949021
112Arginine and proline metabolism_Homo sapiens_hsa003300.16495791
113Alcoholism_Homo sapiens_hsa050340.16368207
114Hippo signaling pathway_Homo sapiens_hsa043900.15623988
115Bladder cancer_Homo sapiens_hsa052190.15034651
116Alzheimers disease_Homo sapiens_hsa050100.14151591
117Allograft rejection_Homo sapiens_hsa053300.13306730
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12393719
119Pathways in cancer_Homo sapiens_hsa052000.10390681

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