THOC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.64987172
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.00494844
3viral transcription (GO:0019083)5.81427956
4ATP synthesis coupled proton transport (GO:0015986)5.73698981
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.73698981
6translational termination (GO:0006415)5.66448979
7ribosomal small subunit biogenesis (GO:0042274)5.42743163
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.25020673
9cotranslational protein targeting to membrane (GO:0006613)5.20397485
10protein targeting to ER (GO:0045047)5.13794982
11maturation of SSU-rRNA (GO:0030490)4.94341986
12protein localization to endoplasmic reticulum (GO:0070972)4.90468214
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.87929368
14translational elongation (GO:0006414)4.86871265
15ribosomal large subunit biogenesis (GO:0042273)4.59664389
16proteasome assembly (GO:0043248)4.57103760
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.54874973
18translational initiation (GO:0006413)4.52275498
19cellular protein complex disassembly (GO:0043624)4.49121447
20viral life cycle (GO:0019058)4.47838225
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.36806344
22respiratory electron transport chain (GO:0022904)4.28412644
23DNA deamination (GO:0045006)4.24266499
24translation (GO:0006412)4.21036299
25electron transport chain (GO:0022900)4.17548510
26telomere maintenance via semi-conservative replication (GO:0032201)4.13639398
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.12554704
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.08669704
29DNA strand elongation involved in DNA replication (GO:0006271)4.04825653
30CENP-A containing nucleosome assembly (GO:0034080)3.88480196
31formation of translation preinitiation complex (GO:0001731)3.88101479
32protein complex disassembly (GO:0043241)3.87517581
33termination of RNA polymerase III transcription (GO:0006386)3.86783039
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.86783039
35regulation of cellular amino acid metabolic process (GO:0006521)3.84031171
36DNA strand elongation (GO:0022616)3.84004217
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.81435434
38chaperone-mediated protein transport (GO:0072321)3.80471097
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77919772
40negative regulation of ligase activity (GO:0051352)3.77028248
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77028248
42chromatin remodeling at centromere (GO:0031055)3.76237295
43telomere maintenance via recombination (GO:0000722)3.74677964
44NADH dehydrogenase complex assembly (GO:0010257)3.71139709
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71139709
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.71139709
47macromolecular complex disassembly (GO:0032984)3.71083374
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.67262079
497-methylguanosine mRNA capping (GO:0006370)3.66648615
50ribonucleoprotein complex biogenesis (GO:0022613)3.65633579
51protein neddylation (GO:0045116)3.65363066
52regulation of mitochondrial translation (GO:0070129)3.64250928
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64049671
54protein complex biogenesis (GO:0070271)3.63410968
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.62022576
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.61625056
57RNA capping (GO:0036260)3.61558397
587-methylguanosine RNA capping (GO:0009452)3.61558397
59GTP biosynthetic process (GO:0006183)3.58732414
60spliceosomal snRNP assembly (GO:0000387)3.55175555
61intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54541261
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54541261
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.52484655
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.52484655
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.52484655
66oxidative phosphorylation (GO:0006119)3.50032791
67mitotic recombination (GO:0006312)3.49613072
68guanosine-containing compound biosynthetic process (GO:1901070)3.49406200
69mitochondrial respiratory chain complex assembly (GO:0033108)3.48589935
70rRNA processing (GO:0006364)3.44040443
71nuclear-transcribed mRNA catabolic process (GO:0000956)3.43407996
72DNA replication initiation (GO:0006270)3.43398765
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.43335076
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.42535348
75cellular component biogenesis (GO:0044085)3.39833774
76establishment of integrated proviral latency (GO:0075713)3.39537677
77ATP biosynthetic process (GO:0006754)3.39293477
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39113361
79signal transduction involved in DNA damage checkpoint (GO:0072422)3.39113361
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39004451
81cytochrome complex assembly (GO:0017004)3.38477441
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.37797208
83transcription-coupled nucleotide-excision repair (GO:0006283)3.35208615
84cullin deneddylation (GO:0010388)3.34573051
85purine nucleoside triphosphate biosynthetic process (GO:0009145)3.34503061
86positive regulation of ligase activity (GO:0051351)3.34153186
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33992338
88protein localization to mitochondrion (GO:0070585)3.32753148
89protein targeting to membrane (GO:0006612)3.32525671
90purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.31689008
91protein targeting to mitochondrion (GO:0006626)3.30556568
92establishment of protein localization to mitochondrion (GO:0072655)3.30235666
93rRNA metabolic process (GO:0016072)3.30080312
94hydrogen ion transmembrane transport (GO:1902600)3.27396824
95RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27267771
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27267771
972-deoxyribonucleotide biosynthetic process (GO:0009265)3.26758872
98deoxyribose phosphate biosynthetic process (GO:0046385)3.26758872
99protein deneddylation (GO:0000338)3.26697455
100pseudouridine synthesis (GO:0001522)3.25281800
101respiratory chain complex IV assembly (GO:0008535)3.24970941
102mRNA catabolic process (GO:0006402)3.24516377
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23881711
104aerobic respiration (GO:0009060)3.23868094
105kinetochore organization (GO:0051383)3.23764274
106DNA replication-independent nucleosome assembly (GO:0006336)3.23357838
107DNA replication-independent nucleosome organization (GO:0034724)3.23357838
108deoxyribonucleotide biosynthetic process (GO:0009263)3.23111911
109pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.21381716
110kinetochore assembly (GO:0051382)3.21065417
111rRNA modification (GO:0000154)3.20307090
112purine nucleobase biosynthetic process (GO:0009113)3.19333848
113histone exchange (GO:0043486)3.18786115
114spliceosomal complex assembly (GO:0000245)3.18466669
115rRNA methylation (GO:0031167)3.15431306
116regulation of ubiquitin-protein transferase activity (GO:0051438)3.09248970
117inner mitochondrial membrane organization (GO:0007007)3.08563250
118pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.07836988
119ribonucleoside triphosphate biosynthetic process (GO:0009201)3.05988521
120mitochondrial transport (GO:0006839)3.01816138
121peptidyl-histidine modification (GO:0018202)3.01815623
122regulation of ligase activity (GO:0051340)2.98757336
123purine nucleoside monophosphate biosynthetic process (GO:0009127)2.98666978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.68142371
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.97408776
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.42318343
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.34841325
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.31431859
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.04419894
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82080016
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.79041963
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.55255547
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.49891024
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21009434
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06231941
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03116488
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.02930419
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00001410
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86785449
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81027389
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78909068
19VDR_23849224_ChIP-Seq_CD4+_Human2.75412302
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68796290
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68723604
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66444097
23DCP1A_22483619_ChIP-Seq_HELA_Human2.63387825
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49346685
25ELK1_19687146_ChIP-ChIP_HELA_Human2.49028430
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42889735
27XRN2_22483619_ChIP-Seq_HELA_Human2.40247529
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33147735
29FOXP3_21729870_ChIP-Seq_TREG_Human2.28340485
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20527962
31TTF2_22483619_ChIP-Seq_HELA_Human2.17117476
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.13233133
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.11482071
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09184087
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05948974
36RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04358423
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00415916
38GABP_19822575_ChIP-Seq_HepG2_Human1.98535180
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93978447
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91312735
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82146037
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80604310
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80228376
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79066366
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.78707466
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.69814407
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65316288
48AR_21909140_ChIP-Seq_LNCAP_Human1.64627221
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64142394
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58338555
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57563862
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54920493
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54185985
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.52713871
55MYC_18940864_ChIP-ChIP_HL60_Human1.52631681
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50936754
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48679241
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48562296
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48441375
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.40632960
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37834960
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17224667
63CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17129717
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16240274
65* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15863879
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15237080
67VDR_22108803_ChIP-Seq_LS180_Human1.09433266
68ELF5_23300383_ChIP-Seq_T47D_Human1.08882086
69IRF1_19129219_ChIP-ChIP_H3396_Human1.07003537
70CIITA_25753668_ChIP-Seq_RAJI_Human1.06307815
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06299328
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.02588930
73KDM5A_27292631_Chip-Seq_BREAST_Human1.02336505
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01996713
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00804370
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.00766556
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98628415
78TFEB_21752829_ChIP-Seq_HELA_Human0.98231303
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97469263
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96784230
81* ER_23166858_ChIP-Seq_MCF-7_Human0.94680974
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94463787
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93051390
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91424680
85NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90814923
86EWS_26573619_Chip-Seq_HEK293_Human0.89286231
87NANOG_16153702_ChIP-ChIP_HESCs_Human0.87665939
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87275114
89ZNF263_19887448_ChIP-Seq_K562_Human0.85750934
90SPI1_23547873_ChIP-Seq_NB4_Human0.85471473
91TP53_22573176_ChIP-Seq_HFKS_Human0.83974330
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82844119
93FUS_26573619_Chip-Seq_HEK293_Human0.82532830
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82517486
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.82227166
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81806246
97* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78781945
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78402905
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78111891
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72748449
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72703178
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.71045836
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70180594
104HTT_18923047_ChIP-ChIP_STHdh_Human0.69976981
105KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69659886
106KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.69327804
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.69251868
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.66345093
109ERG_20517297_ChIP-Seq_VCAP_Human0.66134435
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.64490515
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.62764196
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.61266049
113BP1_19119308_ChIP-ChIP_Hs578T_Human0.61106226
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.59623502
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.58936950
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.57417267
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.56513704
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.56329653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.93484143
2MP0009379_abnormal_foot_pigmentation4.77001944
3MP0004957_abnormal_blastocyst_morpholog3.67185033
4MP0010094_abnormal_chromosome_stability3.33667656
5MP0003077_abnormal_cell_cycle2.84032299
6MP0008058_abnormal_DNA_repair2.74680785
7MP0006036_abnormal_mitochondrial_physio2.65835177
8MP0001529_abnormal_vocalization2.65709486
9MP0003111_abnormal_nucleus_morphology2.50956331
10MP0002837_dystrophic_cardiac_calcinosis2.49614895
11MP0008057_abnormal_DNA_replication2.46747012
12MP0008932_abnormal_embryonic_tissue2.43568443
13MP0003123_paternal_imprinting2.24765929
14MP0008007_abnormal_cellular_replicative2.20316120
15MP0002163_abnormal_gland_morphology2.15338495
16MP0003186_abnormal_redox_activity2.04348635
17MP0002396_abnormal_hematopoietic_system2.03586252
18MP0006292_abnormal_olfactory_placode1.98253959
19MP0002938_white_spotting1.95257077
20MP0006035_abnormal_mitochondrial_morpho1.93052029
21MP0003786_premature_aging1.88839237
22MP0002102_abnormal_ear_morphology1.87391526
23MP0002132_abnormal_respiratory_system1.87240370
24MP0004147_increased_porphyrin_level1.79629219
25MP0006054_spinal_hemorrhage1.75569919
26MP0005646_abnormal_pituitary_gland1.74895658
27MP0002638_abnormal_pupillary_reflex1.73455397
28MP0009697_abnormal_copulation1.72034175
29MP0003718_maternal_effect1.71572734
30MP0003567_abnormal_fetal_cardiomyocyte1.70416309
31MP0003787_abnormal_imprinting1.70397077
32MP0000372_irregular_coat_pigmentation1.67348035
33MP0003806_abnormal_nucleotide_metabolis1.61879628
34MP0003315_abnormal_perineum_morphology1.61571712
35MP0009780_abnormal_chondrocyte_physiolo1.58013983
36MP0003646_muscle_fatigue1.56928194
37MP0008789_abnormal_olfactory_epithelium1.54883510
38MP0001986_abnormal_taste_sensitivity1.53935993
39MP0001905_abnormal_dopamine_level1.52051436
40MP0008877_abnormal_DNA_methylation1.45356356
41MP0003941_abnormal_skin_development1.45351705
42MP0009333_abnormal_splenocyte_physiolog1.42528149
43MP0001188_hyperpigmentation1.41928588
44MP0003890_abnormal_embryonic-extraembry1.40106773
45MP0000490_abnormal_crypts_of1.31577870
46MP0000049_abnormal_middle_ear1.27934654
47MP0005084_abnormal_gallbladder_morpholo1.26695673
48MP0008872_abnormal_physiological_respon1.26673681
49MP0000427_abnormal_hair_cycle1.24279316
50MP0002736_abnormal_nociception_after1.23338033
51MP0001919_abnormal_reproductive_system1.22676815
52MP0002095_abnormal_skin_pigmentation1.19629058
53MP0005075_abnormal_melanosome_morpholog1.17866863
54MP0003121_genomic_imprinting1.17749439
55MP0005379_endocrine/exocrine_gland_phen1.14511895
56MP0002090_abnormal_vision1.14202660
57MP0005408_hypopigmentation1.13900347
58MP0001293_anophthalmia1.13884522
59MP0006276_abnormal_autonomic_nervous1.13857983
60MP0001881_abnormal_mammary_gland1.12672108
61MP0005174_abnormal_tail_pigmentation1.11850916
62MP0002796_impaired_skin_barrier1.05932619
63MP0009250_abnormal_appendicular_skeleto1.02919255
64MP0000566_synostosis1.01388014
65MP0001727_abnormal_embryo_implantation1.01285871
66MP0001764_abnormal_homeostasis1.01065119
67MP0003880_abnormal_central_pattern1.00739851
68MP0002160_abnormal_reproductive_system1.00014108
69MP0001853_heart_inflammation0.99920702
70MP0000350_abnormal_cell_proliferation0.99856961
71MP0002751_abnormal_autonomic_nervous0.98052377
72MP0004142_abnormal_muscle_tone0.97680602
73MP0002877_abnormal_melanocyte_morpholog0.95812501
74MP0000313_abnormal_cell_death0.95060591
75MP0005645_abnormal_hypothalamus_physiol0.94250780
76MP0005397_hematopoietic_system_phenotyp0.91886085
77MP0001545_abnormal_hematopoietic_system0.91886085
78MP0005220_abnormal_exocrine_pancreas0.91561391
79MP0005501_abnormal_skin_physiology0.88798879
80MP0001730_embryonic_growth_arrest0.88627596
81MP0005636_abnormal_mineral_homeostasis0.88440212
82MP0000358_abnormal_cell_content/0.88310828
83MP0002876_abnormal_thyroid_physiology0.87407922
84MP0010234_abnormal_vibrissa_follicle0.87007978
85MP0004808_abnormal_hematopoietic_stem0.86606783
86MP0002210_abnormal_sex_determination0.85470219
87MP0003763_abnormal_thymus_physiology0.85409877
88MP0002277_abnormal_respiratory_mucosa0.84823455
89MP0009046_muscle_twitch0.84254569
90MP0003136_yellow_coat_color0.84029390
91MP0002282_abnormal_trachea_morphology0.83160452
92MP0003656_abnormal_erythrocyte_physiolo0.83060288
93MP0003011_delayed_dark_adaptation0.82594901
94MP0000383_abnormal_hair_follicle0.81479002
95MP0004145_abnormal_muscle_electrophysio0.80667224
96MP0005332_abnormal_amino_acid0.79580778
97MP0005253_abnormal_eye_physiology0.79338814
98MP0010030_abnormal_orbit_morphology0.79275595
99MP0010678_abnormal_skin_adnexa0.79019995
100MP0003938_abnormal_ear_development0.78064609
101MP0003221_abnormal_cardiomyocyte_apopto0.77387097
102MP0004233_abnormal_muscle_weight0.77317823
103MP0005394_taste/olfaction_phenotype0.76983968
104MP0005499_abnormal_olfactory_system0.76983968
105MP0006072_abnormal_retinal_apoptosis0.76946259
106MP0009053_abnormal_anal_canal0.76801227
107MP0002019_abnormal_tumor_incidence0.75970326
108MP0001697_abnormal_embryo_size0.75485957
109MP0001145_abnormal_male_reproductive0.74726969
110MP0001968_abnormal_touch/_nociception0.74524813
111MP0009672_abnormal_birth_weight0.73942622
112MP0008875_abnormal_xenobiotic_pharmacok0.73740745
113MP0001944_abnormal_pancreas_morphology0.73617628
114MP0002822_catalepsy0.73362500
115MP0000631_abnormal_neuroendocrine_gland0.72976402
116MP0000647_abnormal_sebaceous_gland0.72903218
117MP0001929_abnormal_gametogenesis0.72863103
118MP0000627_abnormal_mammary_gland0.70701954
119MP0005551_abnormal_eye_electrophysiolog0.70079752
120MP0000653_abnormal_sex_gland0.69778562
121MP0005410_abnormal_fertilization0.69487276
122MP0002909_abnormal_adrenal_gland0.68225330
123MP0001119_abnormal_female_reproductive0.68024748
124MP0005380_embryogenesis_phenotype0.67849787
125MP0001672_abnormal_embryogenesis/_devel0.67849787
126MP0003122_maternal_imprinting0.67519288
127MP0002080_prenatal_lethality0.66410783
128MP0002693_abnormal_pancreas_physiology0.65630207
129MP0009785_altered_susceptibility_to0.65224965
130MP0003724_increased_susceptibility_to0.64985044
131MP0004215_abnormal_myocardial_fiber0.64876658
132MP0005389_reproductive_system_phenotype0.64648059
133MP0001186_pigmentation_phenotype0.64642573
134MP0000681_abnormal_thyroid_gland0.63158998
135MP0003638_abnormal_response/metabolism_0.62072488
136MP0000015_abnormal_ear_pigmentation0.60513736
137MP0005409_darkened_coat_color0.60306431
138MP0002398_abnormal_bone_marrow0.58620902
139MP0001286_abnormal_eye_development0.58302780
140MP0001485_abnormal_pinna_reflex0.57665720
141MP0000026_abnormal_inner_ear0.56500608
142MP0005266_abnormal_metabolism0.55874488
143MP0008995_early_reproductive_senescence0.54881812

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.78935791
2Abnormal number of erythroid precursors (HP:0012131)5.58594298
3Acute necrotizing encephalopathy (HP:0006965)5.43288595
4Mitochondrial inheritance (HP:0001427)5.07773544
5Abnormal mitochondria in muscle tissue (HP:0008316)4.98362482
6Reticulocytopenia (HP:0001896)4.81475849
7Increased hepatocellular lipid droplets (HP:0006565)4.70449374
8Increased CSF lactate (HP:0002490)4.48647264
9Progressive macrocephaly (HP:0004481)4.44670970
10Hepatocellular necrosis (HP:0001404)4.36439181
11Acute encephalopathy (HP:0006846)4.34903824
12Lipid accumulation in hepatocytes (HP:0006561)4.30090628
13Hepatic necrosis (HP:0002605)4.00294754
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.88478931
15Aplastic anemia (HP:0001915)3.85085282
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.81771653
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.81771653
18Macrocytic anemia (HP:0001972)3.75910361
193-Methylglutaconic aciduria (HP:0003535)3.67944570
20Renal Fanconi syndrome (HP:0001994)3.66054228
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.58426087
22Pallor (HP:0000980)3.55623521
23Increased intramyocellular lipid droplets (HP:0012240)3.41947962
24Exertional dyspnea (HP:0002875)3.39934551
25Birth length less than 3rd percentile (HP:0003561)3.33528904
26Increased serum lactate (HP:0002151)3.28144613
27Generalized aminoaciduria (HP:0002909)3.18380075
28Exercise intolerance (HP:0003546)3.10101488
29Abnormality of glycolysis (HP:0004366)3.02142929
30Increased serum pyruvate (HP:0003542)3.02142929
31Respiratory difficulties (HP:0002880)2.96619397
32Lactic acidosis (HP:0003128)2.96409022
33Cerebral edema (HP:0002181)2.92835851
34Increased muscle lipid content (HP:0009058)2.92059216
35Oral leukoplakia (HP:0002745)2.86689146
36Respiratory failure (HP:0002878)2.86163030
37Type I transferrin isoform profile (HP:0003642)2.84748630
38Methylmalonic acidemia (HP:0002912)2.70321845
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68265578
40Abnormality of the heme biosynthetic pathway (HP:0010472)2.65763947
4111 pairs of ribs (HP:0000878)2.64271097
42Optic disc pallor (HP:0000543)2.59517627
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57857427
44Testicular atrophy (HP:0000029)2.54676777
45Abnormality of renal resorption (HP:0011038)2.42986515
46Rough bone trabeculation (HP:0100670)2.36894983
47Abnormality of urine glucose concentration (HP:0011016)2.32636405
48Glycosuria (HP:0003076)2.32636405
49Cerebral hypomyelination (HP:0006808)2.32461955
50Leukodystrophy (HP:0002415)2.28586360
51Hypoglycemic coma (HP:0001325)2.28080899
52Irregular epiphyses (HP:0010582)2.23329350
53Colon cancer (HP:0003003)2.21932196
54Microglossia (HP:0000171)2.21329026
55Hyperphosphaturia (HP:0003109)2.21134647
56Megaloblastic anemia (HP:0001889)2.20383385
57Breast hypoplasia (HP:0003187)2.19842796
58Reduced antithrombin III activity (HP:0001976)2.19139908
59Cleft eyelid (HP:0000625)2.16023604
60Methylmalonic aciduria (HP:0012120)2.16002099
61Abnormality of methionine metabolism (HP:0010901)2.15370426
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.09083535
63Abnormality of the ileum (HP:0001549)2.08985791
64Sensory axonal neuropathy (HP:0003390)2.06281208
65Microretrognathia (HP:0000308)2.06214757
66Abnormality of the anterior horn cell (HP:0006802)2.06194605
67Degeneration of anterior horn cells (HP:0002398)2.06194605
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04725269
69Dicarboxylic aciduria (HP:0003215)2.04725269
70Abnormality of alanine metabolism (HP:0010916)2.01201806
71Hyperalaninemia (HP:0003348)2.01201806
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01201806
73Congenital, generalized hypertrichosis (HP:0004540)2.00999686
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00867870
75Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98008947
76Microvesicular hepatic steatosis (HP:0001414)1.97899716
77Pancytopenia (HP:0001876)1.97115869
78CNS demyelination (HP:0007305)1.94941220
79Carpal bone hypoplasia (HP:0001498)1.94720317
80Premature graying of hair (HP:0002216)1.90833733
81Abnormality of the preputium (HP:0100587)1.90025820
82Conjunctival hamartoma (HP:0100780)1.89545863
83Breast carcinoma (HP:0003002)1.88467381
84Neoplasm of the adrenal gland (HP:0100631)1.85497403
85X-linked dominant inheritance (HP:0001423)1.85464661
86Aplasia/Hypoplasia of the patella (HP:0006498)1.84041963
87Amniotic constriction ring (HP:0009775)1.83109626
88Abnormality of placental membranes (HP:0011409)1.83109626
89Abnormal protein glycosylation (HP:0012346)1.82604719
90Abnormal glycosylation (HP:0012345)1.82604719
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82604719
92Abnormal protein N-linked glycosylation (HP:0012347)1.82604719
93Abnormal trabecular bone morphology (HP:0100671)1.82316339
94Secondary amenorrhea (HP:0000869)1.82142267
95Poor head control (HP:0002421)1.81942509
96Sparse eyelashes (HP:0000653)1.81664828
97Patellar aplasia (HP:0006443)1.81482425
98Diastasis recti (HP:0001540)1.81465201
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81246400
100Emotional lability (HP:0000712)1.77501017
101Multiple enchondromatosis (HP:0005701)1.77304929
102Type 2 muscle fiber atrophy (HP:0003554)1.75998504
103Depressed nasal ridge (HP:0000457)1.75621681
104Nausea (HP:0002018)1.75162222
105Aplasia/hypoplasia of the uterus (HP:0008684)1.74443611
106Abnormal hemoglobin (HP:0011902)1.74158783
107Muscle fiber atrophy (HP:0100295)1.72592824
108Chromsome breakage (HP:0040012)1.72263069
109Thrombocytosis (HP:0001894)1.71396828
110Absent thumb (HP:0009777)1.70848449
111Pancreatic fibrosis (HP:0100732)1.70498805
112Glossoptosis (HP:0000162)1.67592094
113Abnormality of vitamin B metabolism (HP:0004340)1.67117475
114Abnormal lung lobation (HP:0002101)1.66727160
115Abnormal urine phosphate concentration (HP:0012599)1.66348199
116Renal tubular dysfunction (HP:0000124)1.65569004
117Triphalangeal thumb (HP:0001199)1.65396657
118Septate vagina (HP:0001153)1.64859499
119Myelodysplasia (HP:0002863)1.64525031
120Abnormality of serum amino acid levels (HP:0003112)1.64468886
121Gout (HP:0001997)1.62848238
122Horseshoe kidney (HP:0000085)1.62810460
123Palpitations (HP:0001962)1.62282684
124Calcaneovalgus deformity (HP:0001848)1.61912546
125Lethargy (HP:0001254)1.60889933
126Short middle phalanx of the 5th finger (HP:0004220)1.59255337
127Meckel diverticulum (HP:0002245)1.59083443
128Blindness (HP:0000618)1.58651453
129Abnormal pancreas size (HP:0012094)1.57725712
130Abnormality of the pons (HP:0007361)1.57703637
131True hermaphroditism (HP:0010459)1.55131839
132Abnormality of chromosome stability (HP:0003220)1.54048824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.56516142
2VRK24.32915511
3NEK14.12340485
4NME23.53504724
5BUB13.24722241
6WEE13.22506783
7EIF2AK13.00765655
8NME12.73288492
9VRK12.62923113
10EIF2AK32.55195007
11SRPK12.50354804
12ACVR1B2.29512036
13CDC72.19739551
14PLK42.15492931
15MKNK12.13612998
16BRSK21.95079631
17MST41.93750619
18PIM21.92177752
19NEK21.92038175
20TRIM281.81011503
21MKNK21.80739718
22CCNB11.77480167
23MAP3K121.60812602
24DYRK31.49162715
25TLK11.46337152
26BMPR1B1.42682900
27TAF11.38042221
28CDK81.37956954
29PASK1.35520158
30TNIK1.34722160
31AURKB1.28084896
32ZAK1.25042674
33MAP4K21.23315329
34BCKDK1.21381194
35PBK1.12761375
36PLK31.10567127
37MUSK1.10545245
38CDK191.07642387
39ERBB31.07560748
40PLK11.07148875
41TGFBR11.05165910
42TSSK61.02679600
43LIMK11.01931288
44DAPK11.01870336
45EIF2AK20.96784279
46BRSK10.96199777
47MYLK0.95718413
48DYRK20.91913929
49AURKA0.90022026
50PDK20.89799053
51TEC0.89527232
52RPS6KA40.87984891
53BRAF0.85541065
54MAPKAPK30.83921456
55CSNK2A10.77592917
56ARAF0.76143735
57OBSCN0.73119102
58TAOK20.72928147
59CDK70.70949342
60YES10.70901871
61NEK60.70557527
62OXSR10.68581002
63DAPK30.68202213
64PRKCI0.67716464
65ATR0.67573837
66TTK0.66056078
67ILK0.65115077
68TESK10.64763953
69IRAK30.64449500
70CSNK2A20.63869319
71IRAK40.62117596
72RPS6KB20.60852972
73CAMK2D0.60462931
74TESK20.59915802
75FLT30.59524684
76STK390.59086322
77RPS6KA50.58566358
78ABL20.58111579
79MINK10.57306536
80MAP2K70.56499837
81CSNK1G20.55736362
82CHEK20.55641119
83STK30.53951766
84GRK10.53777142
85ADRBK20.53737676
86CSNK1G10.52935382
87BCR0.51757377
88MAPK130.51566802
89NUAK10.50691308
90CLK10.49582602
91KDR0.49345457
92CSNK1A1L0.47706181
93SCYL20.44416345
94MAP3K110.43622675
95CSNK1G30.42839584
96CSF1R0.42632963
97CAMKK20.42574770
98CSNK1E0.41965867
99INSRR0.41403514
100STK240.40745191
101CAMK2G0.40048692
102WNK30.39394118
103AKT20.39393442
104TXK0.39321928
105CASK0.38968601
106NEK90.38967555
107MAP2K60.38618984
108PIK3CG0.37506134
109PAK40.37161370
110PLK20.36807743
111SIK30.36724771
112PNCK0.36482933
113IKBKB0.36170266
114MAP3K30.35411333
115PRKG20.35120120
116PHKG10.34821492
117PHKG20.34821492
118BTK0.34641922
119MST1R0.34263009
120BMPR20.32680465
121UHMK10.32379746
122PAK10.32177903
123LRRK20.31889274
124ATM0.31058132
125CHEK10.30253181
126MAPK40.27985620
127PIK3CA0.26985108
128NLK0.26780034
129DYRK1A0.26461628
130STK40.26308418
131PIM10.24398274

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.29595254
2Proteasome_Homo sapiens_hsa030504.60631631
3DNA replication_Homo sapiens_hsa030303.94249137
4Oxidative phosphorylation_Homo sapiens_hsa001903.84565959
5Parkinsons disease_Homo sapiens_hsa050123.56552322
6RNA polymerase_Homo sapiens_hsa030203.49239151
7Mismatch repair_Homo sapiens_hsa034303.26330857
8Protein export_Homo sapiens_hsa030602.93529880
9Huntingtons disease_Homo sapiens_hsa050162.76580306
10Pyrimidine metabolism_Homo sapiens_hsa002402.68345290
11Spliceosome_Homo sapiens_hsa030402.67900015
12Homologous recombination_Homo sapiens_hsa034402.50659358
13Nucleotide excision repair_Homo sapiens_hsa034202.46866469
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43327528
15Alzheimers disease_Homo sapiens_hsa050102.39216883
16Base excision repair_Homo sapiens_hsa034102.26481040
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06349322
18* RNA transport_Homo sapiens_hsa030131.97738196
19Basal transcription factors_Homo sapiens_hsa030221.80102534
20Cell cycle_Homo sapiens_hsa041101.65485627
21RNA degradation_Homo sapiens_hsa030181.64172878
22Fanconi anemia pathway_Homo sapiens_hsa034601.51630024
23Non-homologous end-joining_Homo sapiens_hsa034501.50721352
24Purine metabolism_Homo sapiens_hsa002301.48686517
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33087246
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26142320
27Cardiac muscle contraction_Homo sapiens_hsa042601.23839159
28Folate biosynthesis_Homo sapiens_hsa007901.07752725
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03983228
30One carbon pool by folate_Homo sapiens_hsa006701.03128057
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01568433
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00765329
33p53 signaling pathway_Homo sapiens_hsa041150.93111747
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89071489
35Glutathione metabolism_Homo sapiens_hsa004800.88977862
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87105824
37mRNA surveillance pathway_Homo sapiens_hsa030150.81865329
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81074835
39Pentose phosphate pathway_Homo sapiens_hsa000300.79057499
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78695069
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.77019723
42Epstein-Barr virus infection_Homo sapiens_hsa051690.76773276
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72527358
44Sulfur relay system_Homo sapiens_hsa041220.72083262
45Metabolic pathways_Homo sapiens_hsa011000.71967926
46Systemic lupus erythematosus_Homo sapiens_hsa053220.71745596
47Butanoate metabolism_Homo sapiens_hsa006500.70373371
48Sulfur metabolism_Homo sapiens_hsa009200.63760782
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63556073
50Vitamin B6 metabolism_Homo sapiens_hsa007500.60090052
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59820482
52Arachidonic acid metabolism_Homo sapiens_hsa005900.59107399
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.56389690
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52550029
55N-Glycan biosynthesis_Homo sapiens_hsa005100.51747103
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48682356
57Fatty acid elongation_Homo sapiens_hsa000620.46638645
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41389306
59beta-Alanine metabolism_Homo sapiens_hsa004100.39657646
60Carbon metabolism_Homo sapiens_hsa012000.38269379
61Regulation of autophagy_Homo sapiens_hsa041400.38072920
62Herpes simplex infection_Homo sapiens_hsa051680.36611386
63Legionellosis_Homo sapiens_hsa051340.34682505
64Tryptophan metabolism_Homo sapiens_hsa003800.34092522
65Oocyte meiosis_Homo sapiens_hsa041140.32946898
66Allograft rejection_Homo sapiens_hsa053300.31899388
67Vibrio cholerae infection_Homo sapiens_hsa051100.30745346
68Thyroid cancer_Homo sapiens_hsa052160.30399350
69Pyruvate metabolism_Homo sapiens_hsa006200.28614799
70Chemical carcinogenesis_Homo sapiens_hsa052040.27963225
71Alcoholism_Homo sapiens_hsa050340.25660714
72Propanoate metabolism_Homo sapiens_hsa006400.24832259
73Antigen processing and presentation_Homo sapiens_hsa046120.24383705
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23848882
75Fatty acid degradation_Homo sapiens_hsa000710.23179811
76Rheumatoid arthritis_Homo sapiens_hsa053230.22941544
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22079806
78Collecting duct acid secretion_Homo sapiens_hsa049660.21979563
79Linoleic acid metabolism_Homo sapiens_hsa005910.21742302
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20892996
81Asthma_Homo sapiens_hsa053100.20603388
82Fatty acid metabolism_Homo sapiens_hsa012120.20539691
83Primary immunodeficiency_Homo sapiens_hsa053400.20323593
84Autoimmune thyroid disease_Homo sapiens_hsa053200.20069429
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19352827
86Graft-versus-host disease_Homo sapiens_hsa053320.19001192
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18935356
88Galactose metabolism_Homo sapiens_hsa000520.18827283
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17333214
90Fructose and mannose metabolism_Homo sapiens_hsa000510.16876062
91Biosynthesis of amino acids_Homo sapiens_hsa012300.15818487
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15733226
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.15054931
94Viral carcinogenesis_Homo sapiens_hsa052030.14558406
95Peroxisome_Homo sapiens_hsa041460.14429302
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13129117
97Vitamin digestion and absorption_Homo sapiens_hsa049770.12606849
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.12359579
99Tyrosine metabolism_Homo sapiens_hsa003500.12117330
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11524107
101Hematopoietic cell lineage_Homo sapiens_hsa046400.11075092
102Arginine and proline metabolism_Homo sapiens_hsa003300.10969677
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10616985
104Sphingolipid metabolism_Homo sapiens_hsa006000.10245738
105Nitrogen metabolism_Homo sapiens_hsa009100.09958075
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09797853
107Ether lipid metabolism_Homo sapiens_hsa005650.09265586
108Selenocompound metabolism_Homo sapiens_hsa004500.09186037
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08553971
110Type I diabetes mellitus_Homo sapiens_hsa049400.08521602
111Olfactory transduction_Homo sapiens_hsa047400.08220132
112Steroid biosynthesis_Homo sapiens_hsa001000.07207855
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06328298
114Phototransduction_Homo sapiens_hsa047440.05402299
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.04319726
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.04093828
117HTLV-I infection_Homo sapiens_hsa051660.03719515

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